Clinocottus analis (woolly sculpin): 137786089 Help Entry 137786089         CDS       T10471                                  Symbol ryr3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism cana  Clinocottus analis (woolly sculpin) Pathway cana04020   Calcium signaling pathway cana04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:cana00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     137786089 (ryr3)    04020 Calcium signaling pathway     137786089 (ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:cana04040]     137786089 (ryr3) Ion channels [BR:cana04040]  Voltage-gated cation channels   Ryanodine receptor    137786089 (ryr3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  137786089 NCBI-ProteinID:  XP_068433845 LinkDB All DBs Position Unknown AA seq 4943 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCVATIEKDHRKFCLAVEGLGNRVCYLEPTSEAKYVPP DLCVCNFVLEQSLSVRALQEMLATTGQNSEGGGQGGGHRTLLYGHAILLRHSFSDMYLTC LKTSRSLTDKLSFDVGLQEDSIGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSTERYL HLSISYGNIQVDASFMQTLWNVQPTCSSGNMAVGYLTGGHVMRLCHGHDESLTIPGADKS GKEDRIVNYEAGKGASKARSLWRLEPLRISWSGSHIRWGQAFRLRHLATGHYLALTEDRG LVLEDQLKSDTKATSFCFRPSKEKGDSGPKRDIDGMGVPEIKYGDSVCFVMHVATGLWLS YLAPDAKSSRLGPLKRRACLHSEGHMDDGLILQLCQHEESRAARIIRNTTVLFTNFIKAL DSIAEKESMAVAGYVEEVLQTLNDLIEFFKQPDSELEHEEKQCLLRSLIKRQDLFKDEGM LALLSKCIDRMNLYNNAAHFGEMAGEEAGAAWKDILNLLYELLAALIRGNRNNCTQFSRN LDWLVSKLERLESSSGILEVLHCILLESPEALNIIQRSHIKSIISLLYKHGRNHKILDVL CSLCVCNGVAVRANQNLICDNLLPRRDLLLQTRLVNDVQSMRPNIFLGVAEGSAQYKKWY FELVIDQVDHFLTGQPTHLRVGWANTKGYAPYPGGGEGWGGNGVGDDLYSYSFDGLHLWS GRIPRAVASINQHLLNSDDVVSCCLDLGAPSMSFRINGQPVQGMFEDFNTEGFFFPVVSF SAGVKARFLLGGRHGDFKFLPPASYSPCYEALLPKEKMHVEPVKDYKRDHDGVRDLLGTT KFLSQASFIPTPVDTSQIVLPPHLDNVRDKLAENIHELWGMNKIELGWTYGKVRDDNKRQ HPCLVDFGKLPETERNYNVQMSSETLKTLLALGCHVAQVFVNAADDLKKIKLPKDYVMSN GYKPAPLDLSDVKLTAGQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKSRRNPRLVP YAFLDERTKKSNRDSLREAIRTMVGYGYDIDPPDQEAIHILDDQSIDTIRFFRVEQTYAV KTGKWYFEFEALSGGDMRVGWARPGCRPDVELGIDNQAFVFDGYKGRRMHAGSRYFGQPW KKGDVVGCMINMEDKSMIFTLNGELLITSKGSELCFTDFETEDGFIPVCSMGMSQVGHMN LGKDASTFKYYTMCGLQEGFEPFGVNMNRDITMWFSKRLPTFVNIPEDHMHIEVTRIDGT VDSPPCLKVTHKTFGTQNSNSDMTYCRMSMPVEFYSADKILDESQKLSHPPKEDGSVDYG SITTYYHSVRVFAGQDPASVWVGWVTPDYHYYSKNFSLNKTRRVTVTLGDERGRVHESVQ RSNCYLVCGADAVGPSSSSRSNSDLEIGCLIDLATGLVSFTANGMELSTTYQVEPNTKLF PAVFVRPTSANLFQFEFVKIKDAMPLSSAIFKSEHRNPVPQCPPRLDVQTIVAVLWSRMP NTFLNVETARVSERHGWVVQCLEPLEMLAVHIPEENRCLDILELSELEDLRKFHYHTLKL YCALCALGNTRVAHALCSHLDQSQLLNTIDNQYLSGMLREGFYNVLISIHLETAKEARLM MNNEFIIPVTDETRSIKLFPDESKCHSLPGVGLSTSLKPRVNFSAVGIINTKRHQYLYSP QIPLGSLKEKAISMLSEAVQGGGTHIRDPVGGSVEYQFVPILKLIGTLLIMGVLTSEEVR MILLLIDPNVFGEAKEGEEAKGGEVAVTGEKEDVSKNEEKAVEAGEEETKESKPQVKSLL EKSLPESVKRQMCELLHYFCDCELKQRIEAIVSFSDSFVSKLQFNQKFRYNELMLAFNMS AAVTAKKTKEFRSPPHEQINILLNFSAGEDCPCPEEIQEELNSFHEELRLHCGIPVEEEE EEQDTSIKGRLLALLYKIKGPPQKTEKEPTEKEQEAPTNLKELISQTITSWAQESHIQDP ELVRVMFSLLRRQYDGIGELLRAMKKSYTISAASVQDAINLLVSLGQIRSLLSVRMGKEE EKLMIDGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKSQEIAFPKMVASCCR FLCYFCRISRQNQKAMFDHLSYLLENSSVGLASEAMRGSTPLDVAASSVMDNNGLALALE EPDLEKVVTYLAACGLQSCAMLVAKGYPDLGWNPIEGERYLSFLRFVVFCNGESVEENAN VVVKLLIRRPECFGPALRGEGGQGLLAAMKEAIKISEDPALDLPKTSAGVTAGTGEEEGE VIHMGNAIMSFYSALIDLLGRCAPEMHLINAGKGEALRIRAILRSLVPTTDLLGIISIPL QMPVLNKDGTLTEPDMSACFCPDHKASMVLFLERVYGIEDQSFLLQMLEVGFLPDLQASA SLDTEVLSTTETALAMNRYIGSALLPLLTRCAALFSNTEHYAQLLDSTLQTIYRLSKGRS LTKAQRDAIEECLLAICKHLRPSMMQQLLRRLVFDVPMLTEYCMIPLRLLTNHYEQNWKY YCLPSGMGSFGIASEEELLLTKKLFWGTFDSLSQKKYDADLFKMAMSCLCAIAGALPPDF VDASLGATLEKQASVDAQGNFDPKPMNTANISLPEKLESVANKYAEHSHDKWSSEKVSAG WKHGDSLDEKAKTHPLLKPYKALSEKERETYRWPVRESLKSMLAMGWNVECTKEGDALFQ QRESEKQRKISESQINGFSPAPMDLHNVNLSRELQGMVEVVAENYHNIWAKKKKTELVGK GGGSHPLLVPYDTLTAKEKYRDREKAQELFKFLQISGYAVIRGLKDMEQDSSSMEKRFSF KFLKRLLKYIDSAQEFIAHLEAMATSGKTDKSPHDQEIKFFAKVLLPLTDQTFKNHGLYF LSTPSNSLSSCGCASNKEKEMVTSLFCKLAALVRHRISLFGSDSAMMVSCLDILSHTLDT RTVMKSGSELVKAGFRAFFENAAEDLEKLLEMLKLGKFMQSRAQMKSVTQSINYVTVALL PIITALFEHVTTYEFGLDLLLDDVQLSCYRILTCFYSLGTGKSVFVEKHLPALGQSLATL VGAMPVAFLEPLLNAHNPLSVFNTKTPRERAILSMPDTVLEICPEMPLLDRLLKDVSDVS ESGARYSDMPEVIEVVLPMLCNYLSYWWEKGSENSPQGAQCCTMVTSEHLSMILGNILKI LNNNLGIDDAPWMKRIAVYSQPIICKAGADLLRTHFLPTLEKLKNKTVKVVAEEELLKAD SKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSRWLKQPDGDSNELFRMVAEIF ILWCKSHNFKREEQNFVVQNEINNLGFLTGEGKPKMSKSGGDQERKHKRRRGEYYSIQTS LIVAALKKLLPIGLNMCTPGDQELISLAKIRYSLRDTDDEVKEHLRQNFHLQDKSEDPAV QWQLNLYHDVVVKSEEPVNLEHTVDRVQSISAAVFHLEQVEQPLRNKKLVRHKLLSKQRK RAVVACFRMAPLYNLPRHRSINFFIPAYQRLWIEAEEYSFEEKLVQDLAVSTGLALPLPH VPCVGPPLPVLSAECFFSAAPVEPWERTRVGTSPKAPRGGPRSRRAKPFKQRSVRGQRLH DQLRRHRASSGAHVSRKAGFAFLTAAKTPMKIVEEEEEEVAEIQPDPLHQLILHFSHNAL TERSYLEEDPLYIAYADMMAKSCAEDEEEEEEEGKEKTFEEKEMEKQKILYQQARLHARG AAEMVLQMSSASKGRLGPMVTCTLKLGISILNGGNVQVQQKMLDYLKEKRDAGFFKSLSG LMQSCSVLDLNAFERQNKAEGLGMVSEEGSSNTKGSKVLQNDEFTKDLFRFLQLLCEGHN GDFQNFLRTQTGNTTTVNIIISTVDYLLRLQESISDFYWYYSGKNVIDETGRLNFSKALS VAKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFWHVFANMQMKLSQDASQIELLKEL MDLQKDMIVMLLSLLEGNVVNGTIGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTSSEN FREYDPEFKGIISKKEFQKSMESQMQYSQSEIEFLLSCAETDENDMFNYIDFVERFHEPA KDIGFNVAVLLTNLSEHMPHDTRLANFLDLAASVLSYFEPYLGRIEIMGSAKRIERVYFE ISESSREQWEKPQVKESKRQFIFDVVNEGGESEKMEMFVNFCEDTIFEMQLASQISEPDV IEQPEEDEEDEAHSILDELAGEEEAAMESVSAFTSACRSVKKKIGHVRQVFSVKNVSKRF KKIKKLSVKEIITGFFSFFWMLFTGFFKGIYALVFGFFHVIWSSMFGGGLVEGAKNMKVT DILGNMPDPTQFGIHGDVVEGERVDAIESSGRLDTAMAPAGDLEVDTMLEMLSNPKKEGG KHVEPGLGDVSELSAEISTADKKKAAAKPVEKPESEPEKADTENQEKEDKPKKEEEAKEP VVEEKPKTKLSQPKEAAPAFMLSIFAVLEVYLTKMLNYLARNFYNLRFLALFVCFAINFI LLFYKVTGEAGEEIDEEMTWDGEEDDGLDTLFDMDEFVLHEGTGYMLPTLRFLAVFHTVI SLVCVFGYYCLKVPLVVFKREKEIARKLEFDGLYITEQPSDDDIKGQWDRLVINTPSFPS NYWDKFIKRKVINKYGDLYGAERIAELLGLDKSALDFDPTVEAVEKEASLLSWLSSIDTK YHIWKMGVVLTDNFFLYLIWYTTMSIFGHFNNFFFAAHMLDIAMCFKPLRTILSSVTHNG KQLMLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAG GGIGDELEDPAGDSYELYRILFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDM ETKCFICGIGNDYFDRTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKLY QERCWDFFPTGDCFRKQYEDQLG NT seq 14832 nt NT seq  +upstreamnt  +downstreamnt atggctgagggcggagaaggggaagacgagatccagttcttgagaactgatgatgaggtg gtgctccagtgtgtggccaccatcgagaaggatcatcgcaagttttgcctggccgttgag ggacttggaaaccgggtgtgttacctggaacccacatctgaagccaagtatgttcctcca gacttgtgtgtttgtaactttgtgttggagcagtccttgtcggtgcgggccctgcaggag atgctggctacgactgggcagaacagtgaaggggggggtcaggggggtggacaccggacc ctgctctatggtcatgccatcctccttcgccactcctttagtgatatgtacctgacctgt ttaaagacatctaggtctctgacagacaagctgtcatttgatgtcggactacaagaagac tcaataggagaggcctgctggtggaccatccaccctgcgtccaagcagagatccgaggga gagaaagttcgcattggagacgacctgatcctagtcagcgtgtcgacagagagatacctg cacctctccatctcatatggcaacatccaggtggatgcctccttcatgcagaccctgtgg aacgtccagcccacctgctcttcaggcaacatggctgtagggtatttgactggtggacat gtgatgcgtctttgtcatgggcatgatgagagcttgaccatccccggagcagacaagagt gggaaggaggacaggatagtcaactatgaagcggggaagggagcgtcaaaggcccgctca ctttggagactggagcctctcaggatcagctggagcggtagccacattcgctggggtcag gccttcagactgcgccacctggctacaggccattacctggccctgacggaggaccgtgga ctggtcctggaggaccagttgaagtctgacaccaaggccacttccttctgcttcaggcct tccaaggaaaagggtgactcgggtccaaagagggacatcgacggcatgggagtgccagag atcaagtacggagactctgtctgcttcgtcatgcatgtggcgactggactgtggctgtcc tacctggcgcctgatgccaaatcatctcgtctcggacccctgaaaagaagggcctgcctg cattctgagggccacatggacgacggacttatcctgcagctctgtcagcatgaagagtct cgggctgctcgcatcatccgcaacacaacagtcctcttcacaaactttatcaaggctttg gacagcattgcggagaaggagtccatggcggtggccggatatgttgaagaggtgctgcag acgctgaacgacctgatcgagttcttcaaacagcccgattcagagctggagcacgaggag aaacagtgtcttctacgttcactcatcaaacgacaagacctcttcaaagatgagggcatg ctggccctgctatccaaatgcatcgaccggatgaacctgtacaacaacgctgctcacttt ggagagatggcaggggaggaggcaggcgcagcatggaaggacattctcaacctcctctac gaactcttagctgcactgattcgtgggaacaggaacaactgcacccagttttcccggaac ttggactggttggtcagcaaactggagagactggaatcttcatcagggatcctggaagtc ctccactgtattttgttagaaagtccagaggctctgaacatcattcagagaagtcacatt aaatccatcatctcgctgctctacaagcatggacgcaaccacaagattctagatgttttg tgttccctctgtgtttgtaacggggtggcagtgagagccaaccagaatctgatctgcgac aacctgcttcctaggagggatctgttacttcagactcgactcgtcaatgatgttcagagc atgaggccgaacatctttctgggcgtggctgaaggttcagctcagtacaagaagtggtat tttgagcttgtgattgaccaggtggaccacttcttaactggccagccgacacacctgagg gtaggctgggccaacacgaaaggctacgctccgtaccccggtggtggagaaggatggggc ggcaatggtgtcggggatgacctgtactcgtatagctttgatgggcttcatctctggtca ggccgaatcccgagggccgtggcctccattaaccagcacctgctgaactcagacgatgtg gtcagctgctgtctggatttgggcgctcccagcatgtccttcaggatcaacgggcagcct gtgcagggcatgttcgaggactttaacaccgaaggattcttcttcccggtcgtcagcttc tctgcaggtgtcaaggcccgtttcctgttgggtggacgccacggggatttcaagttcctg ccacccgctagttactctccgtgctacgaggcgctgttgcccaaagagaagatgcatgtg gagcctgtgaaggattacaagagggaccatgacggggttcgtgacctgctgggaaccacc aagttcctctctcaggcctccttcatccccactccagttgacaccagccagattgttctt cctcctcacctggacaacgtccgggacaaactagcagaaaacatccacgagctgtggggg atgaacaagattgaactgggctggacctatggcaaggtgcgggatgacaacaagaggcag catccttgccttgtggatttcggaaagctgcctgaaactgaaaggaactacaacgtgcag atgtctagtgaaacacttaagaccctgttggctcttggatgccatgttgcccaggtcttt gttaacgctgcggatgatctgaagaaaatcaaacttcctaaagactacgtgatgtctaat ggttataagcctgcgccacttgatctctctgacgtgaaactgactgcaggtcaggaggtt ctagttgataaactagccgagaatgcacacaacgtgtgggccaaagaccgaattaaacaa ggatggacctatggcatccagcaggatttgaagagcaggcgtaatccccgcttggtgcca tatgcttttctggacgagcgcacaaagaaatctaacagagacagtctgagagaggccatc aggaccatggttggatatggatatgacattgaccccccagaccaggaggcgatccatatt ttggatgatcagagcatcgacaccatccgcttcttccgtgtggagcagacgtatgcagtg aagacgggaaagtggtactttgagtttgaggcactgagtggaggtgatatgagggttggc tgggccagaccaggctgcaggcccgatgtggaactaggaatagataaccaggccttcgtc ttcgatggatacaagggtcgacgtatgcacgcaggcagccgctactttggacaaccttgg aaaaagggcgacgtggtcggttgcatgatcaacatggaggacaaatccatgatcttcacc ctgaacggagagctcctgatcaccagcaagggctccgagctttgctttacagactttgag acggaggacggtttcatccctgtgtgcagtatgggcatgtctcaggttggacatatgaac ctgggcaaggacgccagtacttttaagtactacaccatgtgtggcctccaggaaggcttt gagcccttcggtgtcaacatgaacagagacatcaccatgtggttcagcaagcgccttccc acctttgtcaacatacccgaagaccacatgcatatcgaggtcacgaggattgacggcacg gtggacagccctccctgcctcaaggtcactcacaagacgtttggcacgcagaacagcaac agtgacatgacctactgccgaatgagcatgcctgtggagttctactctgcagacaagata ctggacgaatctcagaaactcagccatcctccaaaagaagatggaagtgttgactatgga agcatcacaacttactaccactcagtgagagtgtttgctggacaagaccctgcatcagtg tgggtgggctgggtcacaccggactatcattactatagcaagaacttcagcctcaacaag acccggagagtcacagtcaccctgggagacgagaggggccgagtccatgagagtgtccag aggagcaactgctacttggtgtgtggagcggacgccgtcggcccgtcttcctccagccgc tccaactccgacctggagatcggctgtctgatcgacctggccactggcctcgtctctttc actgccaatggcatggagctttccacaacgtatcaggtggagccaaatactaagctattc ccagctgtctttgtacgcccaaccagtgcaaacctcttccagtttgaatttgtcaagatc aaggatgcgatgccgctctcgtctgccatatttaagagtgagcacaggaacccggtgccg cagtgcccgccacgtctggatgtgcagaccatcgtggccgtgctgtggagccggatgccg aacaccttcctcaacgtggaaactgctcgggtcagcgagaggcatggctgggtggtccag tgtctggaaccactggagatgctggccgtacatattcctgaagagaacaggtgtttggac atcttggagttatctgaacttgaagacctgagaaagttccactaccacacactgaagctg tactgtgccctctgtgctctgggaaacacccgcgttgctcacgccctctgcagtcacttg gaccaatcacagctgctcaacaccatcgacaaccaatacctctccggcatgttgagagag ggcttctacaatgtactaatcagcatccatcttgagacggcgaaggaggctcgcctaatg atgaataacgagttcatcatccctgtgacggacgagactcgctccatcaagctgttccct gatgagtctaagtgccactcgctgcctggcgtgggcctgagcacctccctcaaacctcgg gtcaacttctccgccgtcggcattattaacacaaagcgccaccagtacctttacagccca cagatccctctgggcagcctgaaggagaaagccatcagcatgctctctgaggctgtgcag ggcggaggcacgcacatccgagacccggtcggcggcagcgtggagtatcagtttgtcccc atcctgaagctgattggaacgctgctaatcatgggagtcttaaccagtgaggaggtgaga atgattctcctcttaatcgaccccaatgtgttcggggaggccaaggagggagaagaagcc aagggtggcgaggtggccgtgacaggggagaaggaagatgtgagcaagaatgaggagaag gctgtggaggcgggagaggaggagacaaaagagagtaaaccgcaagttaaaagtctgctg gagaagtcactgcccgagtctgtgaaacgccagatgtgtgagctgctgcactacttctgt gactgtgagctgaagcaacgcatcgaggccattgtcagcttctccgacagctttgtgtcc aagctgcagttcaaccagaagttccgctacaatgagctgatgctggcgttcaacatgtcc gccgccgtcactgccaagaagaccaaagagtttcgttcacccccacatgagcagatcaat atcctgttgaatttcagtgcaggggaggactgcccgtgtcctgaggagatccaggaggag ctcaactccttccatgaagaattgcggctacactgtggaattcctgtggaggaggaggag gaagagcaggacacttcgataaaaggccgtctcctcgctttactctacaaaatcaaaggt ccacctcagaagacagagaaggaacccaccgagaaggagcaggaggctcccaccaacctg aaggagctgatctctcaaaccataaccagctgggctcaggagtctcacatccaggaccca gagctggtcagagtgatgttcagcctgctaaggcggcagtatgacggcatcggggagctg cttcgggccatgaagaaatcctacaccatcagtgccgcctctgtgcaggatgctattaac ctgctggtatctctgggtcaaatcaggtctctgttgtcagtgcgcatgggcaaggaggag gagaaactgatgatcgatggactcggcgacatcatgaacaacaaggttttctaccaacat cccaacttgatgcgagtgctgggcatgcacgagaccgtcatggaggtcatggtcaacgtt ctgggaggtgacaagtcacaggagatcgccttcccaaagatggtggccagctgttgtcgt ttcttgtgctacttctgtcgtattagccggcagaaccagaaagccatgtttgaccacctg agctacctgctggagaacagcagtgtcgggctggcctctgaagctatgcggggctccact ccgctggatgttgcagcatcttcagtgatggacaacaacggcctggctttggccctggag gagcctgacttggagaaggtggtgacatatctggcagcctgtggtcttcagagttgtgcc atgctggtggcaaagggttacccagacctcggctggaaccctatagagggcgagcgctac ctgtccttcctgcggttcgtcgtcttctgcaatggtgagagtgtggaagaaaatgccaac gtggtggtgaagctgctgatcaggcgtcccgagtgtttcggccccgccctgaggggagag ggaggtcagggtttgctggccgccatgaaggaagccatcaagatctctgaagacccggcc ctggatctgcccaagacttccgctggggtcaccgccgggaccggtgaggaggaaggagaa gtgattcacatgggcaacgccatcatgtccttctactccgctctcatcgacctgctggga cgctgcgctccagagatgcatcttatcaatgcgggtaaaggtgaagcgctgcgtatccga gccatcctgcgctctctggttcccacgaccgacctgttgggcatcatcagcatcccgctc cagatgcccgtgctcaataaagacggtacactgacagagccggacatgtcagcctgtttc tgtccggaccacaaggcctccatggtgctcttccttgaacgagtgtacggcatcgaggac caaagcttcctgctccagatgttggaggtcggcttcctgcctgacctgcaagcctctgcg tctctggacacggaggtgctgagcaccactgagacggcgttggccatgaacaggtacatc ggctcggccctgctgcctctgctcacccgctgtgccgctctctttagcaacacggagcac tacgcacagctgcttgactccacgctgcagaccatctaccggctgtccaaaggacgctca ctcaccaaagcccaaagggacgccatcgaggagtgtctgctggctatctgcaagcacctg cgtccctccatgatgcagcagcttctcaggcggctggtgtttgacgttcccatgctcact gaatactgcatgatacctttacggcttctgaccaaccactatgagcagaactggaagtac tactgcctcccttctggtatgggcagcttcggcatcgcctccgaggaggagctcctcctc accaagaagctcttctggggaacgtttgactccctttctcagaagaagtatgatgctgac cttttcaaaatggccatgtcctgcctgtgtgccatcgccggagccctgccgccagacttt gtggatgccagtcttggagcaacactggaaaaacaggcatcagtggatgcacagggcaac tttgatcctaaacccatgaacactgccaatatctctcttcctgaaaaacttgagtccgtt gccaacaaatatgcagagcattcccatgacaagtggtcctcagagaaggtgtcagcaggc tggaaacatggagacagcctggacgagaaggccaaaacccatccactgctgaagccttac aaggctctgagtgagaaggagagggaaacataccgctggccagtgagagagtcactgaag agcatgctggctatgggctggaacgttgagtgcaccaaggaaggagacgcattgttccaa caacgagaaagtgaaaaacagcgaaagatctctgagtctcagataaatggattcagtccc gctccaatggatttgcacaacgtcaatttgtctcgagagctccagggcatggtggaggtt gttgcagaaaactaccacaacatctgggccaagaagaagaaaactgaactcgttggcaaa ggaggagggagccatccgctgctggttccctatgacaccctgacagccaaagagaagtac agagaccgagagaaagcccaggagctcttcaaatttctgcaaatcagcggctatgccgtc ataagaggtctgaaagacatggagcaggactcgtcatccatggagaagcgtttttccttc aagttcctcaaaaggctactgaagtacattgactctgcccaggagttcatcgctcatctt gaggctatggccacgagtgggaagacggacaaatcacctcatgaccaggaaatcaagttc ttcgccaaggtgttgcttcctctgacagatcaaacgttcaagaaccacggtctctacttc ctgtccacgcccagcaatagcctgagcagctgtggctgtgcttccaacaaagagaaagag atggtcaccagcttgttctgtaagctggcagctcttgtcagacacaggatttctctcttc ggaagtgactctgcaatgatggtgagctgtctggatattctcagtcacacgcttgacacc aggacggtgatgaagtccggctcagagctggtcaaagccgggtttcgggctttctttgag aacgcggcagaggacttggagaagctgctggagatgctgaagctggggaagttcatgcag tcccgtgcccagatgaagagcgtcacacagagcatcaactacgtgaccgtggcgctgctg cccatcatcactgccctctttgagcacgtcacaacatacgagtttggactggatctgttg ttggatgatgtgcagctgtcctgctaccgaatcttgacttgtttctactctctgggaaca ggaaagagcgtctttgtggagaagcatcttccagccctggggcagagcctggcgaccctg gtgggagccatgccggtggcgttcctggagcccctcctcaacgcccacaaccctctgtct gtattcaacaccaagaccccccgagagagagccatcctgagtatgccggacactgtgttg gagatatgtccggagatgcctcttcttgacagactgctgaaagatgtcagcgatgtctcg gagtctggcgctcgctacagtgacatgccagaggtcattgaggtggtccttcccatgctt tgtaactatctgtcgtattggtgggagaaaggctcagagaactctcctcagggtgctcag tgctgcactatggtgacctctgaacacctcagcatgatcttgggaaacatcctcaaaatc ctgaacaacaacctgggcatcgatgacgccccctggatgaagaggattgcagtctattct cagccaattatctgcaaggctggagcagatctgctgaggacccacttcctgcccacactg gaaaaactgaagaacaagacagtgaaggttgtggctgaagaggagctgctgaaggccgac agtaaaggtgacacccaggaggccgagctgctcatcctggatgagtttgctgtgctctgc agagacctctacgccttctaccccatgctcatccgttatgtggacaacaacaggtccaga tggctgaagcagccggatggcgactccaatgagctcttcaggatggtggcggagatcttc atcctctggtgcaagtcccacaactttaagcgtgaggagcaaaactttgtggttcagaat gagatcaacaatttgggcttcctgactggagagggcaagccgaagatgtccaagtcaggg ggcgaccaggagaggaaacacaagcgccgccgaggcgagtactactccatccagacctcc cttatcgtagccgccctgaagaaactgctgcccatcggcctcaacatgtgcaccccagga gaccaggagctcatctccctcgccaagatacgctacagtctgagagacactgatgatgag gtgaaggagcacttgcgtcagaatttccatcttcaggacaagtctgaggacccagcggtt cagtggcagctgaacttgtaccacgacgtggtggtgaagagcgaggagcccgtaaacttg gaacacacggtggaccgagtgcagagcatctcagctgcggtcttccacctggagcaggtg gagcagcctctgagaaataagaagttagtccggcataagctcctgtccaaacagcgtaag cgcgctgtggtggcgtgtttccgcatggctccgctctacaatctacccaggcatcgctct atcaacttcttcatcccggcctatcagagactttggatagaggcagaggagtactccttt gaggagaagctagttcaggatctggcagtaagtactgggctcgccttgcccttgccccat gtgccctgcgttggcccccctctgccagtcctgtctgccgaatgcttctttagcgctgcg cccgtcgagccttgggagcgcacccgggtggggacctcgcccaaagcacccaggggcggc cctcgctctaggcgcgcgaaacccttcaaacagagatccgtcaggggtcagaggctgcat gaccaactcaggagacacagggccagctccggcgctcacgtctctaggaaagcaggcttt gcctttctgacagcagcgaaaaccccaatgaaaattgtggaggaggaggaagaggaggtg gctgagatccaaccggaccctcttcaccaactcatcctccacttcagccacaacgctctg acagagagaagttacttggaagaagatcctttgtatattgcgtatgcggacatgatggca aagagctgtgcagaggatgaggaggaggaagaagaggaagggaaagaaaagacgtttgag gaaaaagagatggagaagcaaaagatcctgtaccagcaggcgaggctgcacgcccgcggg gccgcggagatggtgctgcagatgagcagcgccagtaaaggacgtctgggccccatggtg acctgcaccctcaaactaggaatctccatcttaaatggaggcaatgtacaagtgcagcag aaaatgcttgattacctgaaagagaaaagagatgcaggatttttcaagagtctctcagga ctgatgcagtcttgcagtgtcttggacttgaatgcatttgagaggcagaacaaagcagaa ggacttggcatggtgtcagaggaaggctcatccaacactaagggttccaaggtgctacag aatgacgaattcactaaagatctgttccgctttttgcaacttctgtgcgaggggcacaat ggagatttccagaacttcctgagaacccaaactggaaacacgaccacagtcaacatcatc atcagcactgtggactacctgctgcgtctccaggaatctatcagtgacttctactggtac tactctggcaaaaacgtcattgatgaaactggaagactcaacttctccaaagctttatct gttgccaagcagatattcaactctctcactgagtatattcagggcccgtgtattgggaac cagcagagtttagctcacagcagactttgggatgcagttgttggattctggcatgtattt gccaacatgcaaatgaagctgtctcaggacgccagtcagattgagctgttgaaggagctg atggatctccagaaggacatgattgtcatgttactgtctctgctcgagggtaatgtggtg aacggaacgattggaaagcagatggttgacaccctggtggagtcttctagcaatgtggag atgatcctcaagttctttgacatgttcctcaaactgaaggacctgacgtcctctgaaaac ttcagagagtacgaccccgagttcaaaggcattatttcaaagaaggagttccagaagtca atggagagccagatgcagtacagccagtctgagattgagttcttgctctcgtgtgcagag acggacgaaaatgacatgtttaattacatcgactttgtggagcggttccacgagccggcc aaagacatcggcttcaacgtggcagtgctgctgaccaacctgtctgaacacatgccccac gacaccagactcgccaacttcctcgacctggcggcgagtgtcctgagctactttgagcct tacctgggtcgtattgaaatcatgggcagcgcaaagcggatagagagggtgtactttgag atcagcgagtcgagccgcgagcagtgggagaagccgcaggtcaaagagtccaagcgccag ttcatctttgacgtggtcaacgagggcggggagagcgagaagatggagatgtttgtgaat ttctgcgaggacaccatctttgagatgcagctggcctcgcagatctccgagccagatgtg atcgaacaacccgaggaggacgaagaggatgaggcacacagtatcctggacgagctggcc ggagaggaagaggccgccatggagtcggtctcagccttcacctctgcgtgccgctcagtc aagaaaaagattggccatgtccgccaagtcttttccgttaaaaacgtgagcaagcggttc aaaaaaatcaagaagctgagcgtcaaggagattattaccggcttcttctccttcttctgg atgctcttcaccggcttcttcaagggaatctacgccctcgtctttgggttcttccacgtc atctggtcctccatgttcggcggcggcctcgtcgagggagccaagaacatgaaggtgacg gacatcctcggaaacatgcccgacccgacccagttcggtatccacggagatgtggtcgaa ggagagagagtggatgcaatagagtcgtcgggaaggttggatacggccatggcaccagca ggcgacttagaggtcgataccatgttggagatgctgtcgaatcccaagaaggaaggaggg aaacatgtggagccgggcctgggggatgtttctgagttgagtgcagagatctccactgct gacaagaagaaagctgctgccaagcccgtcgagaagcccgaaagcgaaccggagaaagca gacacagagaaccaggagaaggaggataagccaaagaaggaggaggaggccaaggagccg gtggtggaggagaagcccaaaaccaaattgagtcagccgaaagaggccgcgccggccttc atgttgagcatctttgctgttctggaggtctacctgacgaagatgctgaactacctcgcc cggaacttctacaacctgcgtttcctggctctgttcgtgtgttttgccatcaacttcatt cttctcttctacaaggtcactggggaagccggtgaagaaatagatgaggaaatgacgtgg gatggcgaggaggacgatggcttggacaccttattcgacatggatgagtttgtcctgcat gagggcaccggctacatgctccccacgctgcgcttcctggctgtattccacacggtcatc tcccttgtgtgtgtgttcgggtactactgtctgaaggtccccttggtggtgttcaagaga gagaaagagatcgccaggaagcttgaattcgacggtctctacatcaccgagcagccgtct gacgacgacatcaagggccagtgggatcgactcgtcatcaacaccccgtctttccccagc aactactgggacaagttcatcaagcgcaaggtgatcaacaaatacggcgacctttatgga gccgagcgcatcgccgagctcttgggcctggataagagcgctctggactttgaccccacg gtggaggcggtagagaaggaggcgtctctgctctcctggctgagctccattgatacaaag taccacatctggaaaatgggcgtggttctgactgacaatttcttcctgtatctgatctgg tacaccaccatgtccattttcggacacttcaacaacttcttctttgcggcccacatgctg gacatcgccatgtgcttcaagccccttcgcaccatcctgtcttccgttacccacaatggc aagcagctcatgctgaccgtgggtttgctggccgtggtcgtctacctgtacaccgtggtc gccttcaacttcttcaggaagttctacaataagagcgaggatgaagacgagcccgacatg aagtgtgacgacatgatgacgtgctatttgttccacatgtatgtgggcgtgagagctggc ggtgggattggagacgagttggaggacccggctggagactcctatgagctctaccgcatc ctgtttgacatcaccttcttcttcttcgtcatcgtcatcctgctggccatcattcagggt ttgatcatcgacgccttcggtgagctcagagaccagcaggagcaggtgaaggaggacatg gagaccaaatgcttcatctgcggcatcgggaacgactactttgaccggacgcctcacggg tttgaaacccacaccttacaggagcacaacctcgccaactacctgttcttcctgatgtac ctgatcaacaaggacgagactgaacacacgggacaggagtcgtacgtgtggaagttgtac caggagagatgctgggacttcttccccaccggagactgtttccgtaagcaatacgaggac cagttgggttag

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