Cercocebus atys (sooty mangabey): 105600621 Help Entry 105600621         CDS       T07242                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism caty  Cercocebus atys (sooty mangabey) Pathway caty04020   Calcium signaling pathway caty04371   Apelin signaling pathway caty04713   Circadian entrainment caty04921   Oxytocin signaling pathway caty04970   Salivary secretion caty05010   Alzheimer disease caty05012   Parkinson disease caty05020   Prion disease caty05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:caty00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     105600621 (RYR3)    04020 Calcium signaling pathway     105600621 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     105600621 (RYR3)   09154 Digestive system    04970 Salivary secretion     105600621 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     105600621 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     105600621 (RYR3)    05012 Parkinson disease     105600621 (RYR3)    05020 Prion disease     105600621 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     105600621 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:caty04040]     105600621 (RYR3) Ion channels [BR:caty04040]  Voltage-gated cation channels   Ryanodine receptor    105600621 (RYR3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_5 EF-hand_8 Motif Other DBs NCBI-GeneID:  105600621 NCBI-ProteinID:  XP_011947370 Ensembl:  ENSCATG00000031383 LinkDB All DBs Position Unknown AA seq 4882 aa AA seqDB search MAEGGEGGEDEIQFLRTEDEVVLQCIATIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIP PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGFQRKAAQGGGHRTLLYGHAILLRHSFS GMYLTCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSV SSERYLHLSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTI PSTDQNDSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLA LTEDQGLILQDRAKADTKSTAFSFRASKELKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQ HIASGLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTA LFSQFVSGNNRTAAPITLPIEEVLQTLQDLIAYFQPPEEEMRHEDKQNKLRSLKNRQNLF KEEGMLALVLNCIDRLNIYNSVAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRNNCA QFSNNLDWLISKLDRLESSSGILEVLHCILTESPEALNLIAEGHIKSIISLLDKHGRNHK VLDILCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQ YKKWYFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDG LHLWSGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFF PVMSFSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDADGVRD LLGTTQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRD DNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKN YMMSNGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRN PRLVPYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADSAVEKVSIDKIRFFRV ERSYAVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGSRGQRWHQGSG YFGRTWHPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIGNGFVPICCLGLS QIGRMNLGTDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEV MRIDGTMDSPPCLKVTHKTFGTQHSNADMIYCRLSMPVECHSSFSHSPCLDSEAFQKRKQ MQEILSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERG RVHESVKRSNCYMVWGGDIVASSQRSNRSNVDLEIGCLVDLAMGMLSFSANGKELGTCYQ VEPNTKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDVQTIQ PVLWSRMPNSFLKVESERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMR FHYHTLRLYSAVCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRAGFYDLLISIHLA NAKERKLMMKNEYIIPITSTTRNIRLFPDESKRHGLPGVGLRTCLKPGFRFSTPCFVATG EEHQKQSPEIPLESLRTKALSMLTEAVQCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMG VFDDDDVRQILLLIDPSVFGEHSADTEEGTEKEEVTQVEEKAVEAGEKAGKEAPVKGLLQ TRLPESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSA ALTARKTKEFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLLHCGVPLEEEEE EEEDTSWTGKLRALVYKIKGPPKPEKEQPTEEEERCPTTLKELISQTMICWAQEDQIQDA ELVRMMFNLLRRQYDSIGELLQALRKTYTISHASVSDTINLLAALGQIRSLLSVRMGKEE ELLMINGLGEIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLSTEKSQIAFPKMVASCCRF LCYFCRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEE PDLEKVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASV VVKLLIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVSTEADEEEE EIVHMGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIP LKLPSLNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRAS ASLDTVSLSTTEAALALNRYICSAVLPLLTRCAPLFAGTEHCTSLIDSTLQTIYRLSKGR SLTKAQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWK YYCLPSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPD YLDTRITATLEKQISVDADGNFDPKPINTVNFSLPEKLEYIVTKYAEHSHDKWACDKSQS GWKYGISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALV QQRENEKLRSVSQANQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELE SKGGGSHPLLVPYDTLTAKEKFKDREKAQDLFKFLQVNGVIVSRGVKDMELDASSMEKRF AYKFLKKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRL YFLSSPLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTL DTRTVMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVA LLPILTSIFEHVAQHQFGMDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECVA SLAAAIPVAFLEPTLNRYNPLSVFNTKTPRERSILGIPDTVEDMCPDIPQLEGLMKEIND LAESGARYTEMPHVIEVILPMLCNYLSYWWERGPENLPPSTGQCCTKVTSEHLSLILGNI LKIINNNLGIDEASWMKRIAVIIVQNFPVYAQPIISKARPDLLRSHFIPTLEKLKKKAVK TVQEEEQLRADGKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDADS DQLFRMVAEVFILWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQ ERKKTKRRGDLYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYGHRDTDEEVRE HLRNNLHLQEKSDDPAVKWQLNLYKDVLKSEEPFNPEKTVERVQRISAAVFHLEQVEQPL RSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKL VQDLAKSPKVEEEEEEETEKQPDPLHQIILYFSRNALTERSKLEDDPLYTSYSSMMAKSC QSGEDEEEDEDKEKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVET LKLGIAILNGGNAGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLG MVTEEGTLIVRERGEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVII STVDYLLRLQESISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQ QSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVN GTIGKQMVDTLVESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKREFQKAM EGQKQYTQSEIDFLLSCAEADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPND SRLKCLLDPAESVLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQF IFDVVNEGGEQEKMELFVNFCEDTIFEMQLASQISESDSADRPEEEEEDEDSSYVLEMAG EEEEDGSFEPASAFAMACASVKRNVADFLKRATLKNLRKQYRNVKKMTAKELVKVLCSFF WMLFLGLFQMLFTILGGIFQILWSTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDTM EAERAEVMEPGITTELVHFIKGEKGDTDIMSDLFGLHPKKEGSLKHGPEVGLGDLSEIIG KDEPPTLESTVQKKRKAQAAEMKAANEAEGKVESEKADMEDGEKEDKAKEEEQAEYLWTE VTKKKKRRCGQKAEKPEAFTANFFKGLDIYQTKLLHYLARNFYNLRFLALFVAFAINFIL LFYKVTEEPLEEETEDVANLWNSFNDEEEEEAMVFFVLQESTGYMAPTLRALAIIHTIIS LVCVVGYYCLKVPLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNN YWDKFVKRKVINKYGDLYGAERIAELLGLDKNALDFSPVEETKAEAASLVSWLSSIDMKY HIWKLGVVFTDNSFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGK QLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGG GIGDEIEDPAGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDME TKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQ ERCWDFFPAGDCFRKQYEDQLG NT seq 14649 nt NT seq  +upstreamnt  +downstreamnt atggccgaagggggagaaggaggcgaggacgagatccagtttctgaggactgaggatgaa gtggtactccagtgcatcgccaccattcacaaggagcagaggaagttttgcctggcagcc gagggacttgggaatcgcctgtgcttcttggaacccacttcagaagccaagtacattcct ccagatctctgcgtctgcaattttgtgctggaacagtccctatctgtcagagccctgcag gaaatgcttgccaacacaggtgaaaatggcggcgaagggtttcaaaggaaggcagcacaa ggaggtggccacaggaccctgttatatggccatgcaattctcctgaggcactctttcagc ggaatgtatctaacatgcttgactacatcaagatcccagacagacaaacttgcctttgat gtaggtctacgggaacatgccacaggagaagcctgttggtggactatacatcctgcttcc aaacagaggtccgaaggagagaaagttagaattggagatgacctcatcctcgtcagcgtg tcctctgaaagataccttcatctctcagtatcaaatggtaacatacaagtggatgcctcc tttatgcagacactctggaatgtacatcctacgtgctcaggaagtagcatcgaagaagga tacctacttggtgggcatgtagtgcgtcttttccatggtcatgatgagtgtctgacgata ccatctacagaccagaatgattcccagcacaggaggatattctacgaagctgggggagct gggactcgagccaggtctctgtggagagtggaaccacttcggataagttggagtggcagt aacatcagatggggccaggcttttcgactccggcatctcaccacaggccactacctggcc ttgacagaagaccaaggccttatactacaagaccgggcaaaggcagacaccaagtccaca gctttctctttccgggcatcaaaggaactcaaggagaaattagattccagtcacaagcga gacatagaaggcatgggagttccggaaatcaagtatggagattctgtctgctttgtacag catatagccagtggtctgtgggtgacctacaaagcacaagatgccaaaacttcccgcctg ggacctctgaaaagaaaggtcatactccatcaggaaggccacatggatgatggattaaca ctgcagagatgccagcgtgaggagtcccaggctgctcggatcatccggaacactacagcc ttattcagccagtttgtcagtggaaacaatcgcacagctgcccccatcaccctgcctata gaagaagtcctgcagaccctacaggacttgatcgcctacttccagcccccggaggaggag atgcgacatgaagacaagcagaacaagctccgctcactcaaaaacagacaaaatcttttc aaggaagagggaatgttggctcttgtcttaaattgcattgaccgcttaaatatctacaat agcgtagcacactttgcagggattgcaagggaagagagtggcatggcctggaaagaaatt ctgaacctcctctacaaattgctggctgctctcattcgtggaaacagaaacaattgcgct caattctccaataaccttgattggctcatcagtaaattggacagactagaatcttcctca ggtatcttggaagttttgcactgcatcttaactgaaagtccggaagccttaaatctgata gcagagggccacatcaagtccatcatctccctgttggataagcacgggcggaatcacaag gttctggatatcctgtgctccctctgtctctgcaatggggttgcagtgagagccaaccag aatctgatctgtgacaacctgctgccccggagaaacctgctcttgcagacacgactgatt aacgatgtaaccagtatccggccaaacatcttcctgggagtcgcggagggctcagcccag tacaagaagtggtacttcgagctgattatcgaccaggtggaccccttcctaacagcagag cccacacatctgcgggtgggctgggcctcttcctcaggctatgctccatacccaggcggt ggagaaggatggggaggcaatggtgttggcgatgacctgtactcctatggctttgatgga cttcacctttggtcaggccggatacccagagctgtggcttccatcaaccagcacctcctg agatcagatgatgtggtaagctgctgcctggacctcggggtgcccagcatttcattccgc atcaatggacaacctgtgcaggggatgtttgagaacttcaacacagacgggctcttcttc cctgtgatgagcttttcagcaggtgttaaagtacgtttcctgatgggtggacgtcatgga gagtttaagttcctgcctccctctggctatgccccttgctatgaagccttacttccaaaa gagaagatgagattggaacctgtcaaagaatataaacgtgatgctgatggcgttagagat ctcttgggtaccacccaattcctctcccaagcctctttcatcccatgccccatagacacc agtcaggttgttttgccacctcacctcgaaaagatccgagacagactagctgaaaacatt cacgagctttggggaatgaataaaatagagcttggctggactttcggcaagatacgagat gacaataaaagacaacacccttgccttgtggagttttcaaagctccccgaaactgagaag aattataacctgcaaatgtcgactgaaaccttgaaaaccctcctggccctggggtgccac attgctcatgttaacccagctgctgaggaggatctcaagaaggtcaaactgcccaaaaac tatatgatgtccaatggctataagccagcccctttggatttgtctgatgtgaagctgtta cctcctcaagaaattttagtggataagcttgcagaaaatgcgcacaatgtttgggcaaaa gacagaataaaacaaggatggacctatggcatccaacaggatttgaagaacaaaagaaat ccccgtctggtgccatatgcattactggacgagcgtaccaagaagtcaaacagggacagc ctgcgggaagctgtgcgcacttttgttggttatggatataacattgagccatcagaccaa gaactagctgactcggctgtggagaaagtcagcatagacaagatccgatttttccgggta gagcgatcttatgcagtgagatctggaaagtggtattttgagtttgaggtggtgactgga ggagacatgcgagttggctgggccaggccaggctgtcggcctgatgtcgagctgggggcc gatgaccaagcctttgtgtttgaaggcagcaggggccagcgttggcatcaaggaagtggg tattttgggcgtacgtggcatccaggagatgtggtcggatgtatgattaacctggatgat gcttcaatgatcttcacgctgaatggggagctgctgatcaccaacaaaggctctgaactt gccttcgctgactacgagattgggaatggctttgtgcccatctgctgtctggggctgtct cagattggccgcatgaatctcgggacagatgccagtaccttcaagttttataccatgtgc ggtctccaagagggctttgagccttttgctgtcaacatgaacagagatgttgctatgtgg ttcagcaagcgcctcccgacgtttgtcaacgtgccaaaggaccatccacacatagaggtc atgaggattgatggcaccatggacagccctccgtgtctcaaggtgacccataagacattt ggcacacagcatagcaatgccgacatgatctactgccgcttgagcatgcctgtcgagtgc cactcttccttcagccacagcccctgtctggacagtgaagctttccagaaaaggaaacag atgcaagaaatactctctcatacaacaacacagtgctactatgccatccgcatctttgct ggacaggatccatcctgcgtctgggtcggatgggtgactccagactatcacttgtacagt gaaaagtttgacctgaataaaaactgcacagtgactgtcaccctaggggatgaaagaggc cgggtacacgaaagtgtgaaacgcagcaactgctacatggtctggggcggggacatagtg gccagttcccagagatcaaatcggagcaacgtggacctggagatcggctgtcttgtggat ctggcaatgggcatgttgtccttctcagccaacggaaaagaactgggcacctgctaccag gtggagcccaacaccaaagtgtttccggcagtcttcctgcagcctacaagtacttccttg tttcagtttgaacttggaaagctgaagaacgcaatgcccctgtcggcagccatattcaag agtgaagagaagaacccagtcccacagtgtccacctcggctggacgtccagaccatccag cccgtgctctggagccgcatgcccaacagcttcctgaaggtggagagcgagcgtgtgagc gagcgccatggctgggtggtacagtgcctggagcccctgcagatgatggcactccacatc cccgaggagaacaggtgtgtggatatcctggagctctgtgagcaggaggacctgatgcga ttccattaccacacgctgaggctctacagcgcggtgtgcgccctgggaaacagccgcgtg gcctatgccctgtgcagccacgtggacctctcccagctcttctatgccattgacaacaag taccttcctggcctccttcgagctggcttctatgacctgctcatcagcatccacctggcc aatgccaaggagaggaagctgatgatgaagaacgagtacatcatccccattaccagcacc accaggaatatccgcctcttcccggacgagtccaagaggcatggactgcctggggtgggc ctgagaacatgtctcaagcccgggttcaggttctccaccccttgctttgtcgcaactggt gaggagcaccaaaaacagagccctgagattcccttggagagtctcaggacgaaggctctg agtatgctgacagaggcagtgcagtgcagcggggcccacatccgagaccccgtagggggg tctgtggagttccagtttgtgcctgtgctgaaactcattggaaccctgctggtcatgggc gtgtttgatgatgacgatgttcggcagatcctcctcctgattgatccctctgtgtttggg gagcatagcgcagacacagaggagggaacagaaaaggaggaagtgacccaggtggaggag aaggctgtggaggctggggagaaggccggcaaggaggctcctgtcaaaggcttgttgcag actcgattacccgagtccgtcaagctgcagatgtgtgagctcctcagctatctctgcgac tgtgagctgcagcaccgagtggaggccattgtggcatttggtgacatttatgtctccaag ctgcaggcaaatcagaagttccgctacaatgagctcatgcaggccctgaacatgtctgcg gccctgactgcccggaagaccaaggagttccgctcacccccacaggagcagatcaacatg cttcttaactttcaactgggagagaactgcccctgcccagaggagattcgggaggagctg tatgatttccatgaggaccttctccttcactgtggggttcctttggaagaagaggaagag gaggaggaggacacctcctggacaggaaaactccgtgccttggtttacaaaatcaaaggc ccacccaagccagagaaggaacagccaacggaggaggaggagagatgccccacaacattg aaggagctcatctcacagacgatgatctgctgggcccaggaggaccagatccaggatgca gagctggtccgaatgatgttcaacctcctccggagacagtatgacagcatcggggagctg ctgcaggcgctgcggaagacctacaccatcagccatgcctctgtaagcgacaccatcaac ctgctggctgccctgggccagatccgctccctcctcagtgtcaggatgggcaaggaagag gaattgctcatgatcaacgggctgggagaaataatgaacaacaaggtgttttaccagcat cccaacctcatgagagtcctgggcatgcacgagacggtgatggaggtgatggtgaacgtg ttgagtacagagaaatctcagattgcatttccaaagatggttgctagctgctgccgtttc ctttgctatttctgtcgaattagccggcaaaatcagaaggccatgtttgagcatctgagt tatcttctggagaatagcagcgttggcctagcctccccgtcgatgaggggatccaccccg ctggatgtggcagcgtcctctgtgatggacaacaacgagttagcgctgggcttggaggaa ccagacctggagaaggtggtgacctacttggcaggctgtggcctacagagctgccccatg cttctggccaaaggataccctgacgtcggctggaaccccatcgaaggggaacgctacctg tccttcctgaggtttgccgtcttcgtgaacagtgagagtgtggaagaaaatgccagcgtt gtggtcaagctgctcatcagacgcccagagtgcttcggcccggccctgcggggcgagggg ggaaacggactgttggcggccatgcagggtgccattaagatctctgagaaccccgcgctt gacctcccctctcaaggatacaaaagagaagtcagcacggaggccgatgaagaggaagaa gaaatcgtgcatatgggcaatgcaattatgtcattttattcggcccttatagatctactg ggccgctgtgctcctgaaatgcacctcatccagacgggaaagggggaggccatccgcatc aggtccatactgcgctccctggtccccacagaagacctggttgggatcatcagcatcccc ttgaaactgccctcccttaacaaagatgggtcggtcagtgagccggatatggcggccaac ttctgccctgaccacaaggcacccatggtgctgttcttggaccgcgtctatggcattaag gatcaaacttttctgctccacttgctggaggttggatttttacctgacctgagagcttct gcctctctagatacagtttccctgagcaccacagaggctgcgcttgcactaaataggtat atatgttctgctgtgctaccgctcctcacaagatgtgctcctctctttgccggaacagaa cactgcacctctctgattgattccacactgcagacgatatacaggctttccaagggacgt tccctcaccaaagcacaaagggacactatagaagaatgtctgcttgccatttgcaatcac ttgaggccttccatgttacagcagctcctgcgacgcctcgtttttgatgtgccccaactc aatgaatactgcaaaatgcctctcaagcttctgacgaatcactatgaacagtgctggaaa tattactgcctgccttcaggatgggggagctacgggctagctgtggaagaagagctgcac ctaacggagaagcttttctgggggatttttgactctctctcccataagaaatatgaccca gatcttttccgaatggccctgccttgtctcagtgctatagctggggccttgccaccggat tatttagataccagaatcacagccacattggagaaacagatctcagtggatgcagatggc aactttgatcccaaacctatcaacactgtgaatttttccttgcctgaaaaattggaatac atcgtcaccaagtatgctgagcattcacatgataaatgggcctgtgacaagagtcagagc ggatggaaatatgggatttccctggatgaaaatgtgaagacccacccactgataaggcct ttcaagacattaacggagaaggagaaggaaatttatcgctggcctgcccgagagtccctg aaaaccatgctagctgtgggctggactgtggagaggaccaaagagggagaagcgttggtt caacagcgggaaaatgagaagcttcgaagcgtgtcccaggccaaccagggcaacagctac agccctgctcccctcgacctctcaaacgttgtactctccagagagctccagggaatggtg gaggtcgtggctgagaactatcacaatatctgggccaagaagaagaagctggagctggag agcaaaggtggtggcagtcaccctcttctggtaccatatgacaccttgactgccaaagaa aagttcaaggaccgggagaaggcacaggacctgtttaagttcctccaagtgaatggcgtc atagtttccaggggtgtgaaggatatggagctggatgcctcctccatggaaaagaggttt gcctataagttcttgaagaagatcctgaaatacgttgattcggcacaagaatttattgcc catttagaagccattgtcagcagtgggaaaactgaaaagtctcctcatgaccaggagatc aaattctttgccaaagttctcctcccactggttgaccagtacttcaccaatcatcgcctc tacttcttgtcatcccctctgaagccccttagcagcagcggatacgcctctcataaggag aaagaaatggtggccagcctgttctgcaaacttgctgcccttgttagacacagaatttcc ctctttggtagtgattctactacaatggtgagctgtcttcacatcttagctcagacactt gacacaaggactgtcatgaagtcaggctcagagctggtgaaggctgggttacgagcattc tttgaaaatgctgcagaagacttggagaagacttcagaaaacctgaaacttgggaagttc acccattcccgaacgcagattaaaggcgtttctcagaatattaactatactacagtggcc ctgctccccatcctgacgtccatctttgagcacgtcgctcagcatcagtttggaatggat ctactcttgggtgatgtgcagatttcctgctaccacatactgtgcagcctctactccctt gggacaggaaagaacatttatgttgaaaggcaacgccctgcccttggagaatgtgtggcc tcgctggcagctgccataccagtggcattcctggagcccaccctcaatcgctacaatcct ctctcggtcttcaacaccaaaacccccagggagaggtctattctggggataccagacacg gtggaagacatgtgtcctgacatcccccagctggaaggcctgatgaaggaaatcaacgac ctggccgagtcaggggcgcggtacacagagatgccgcatgtcatcgaggtgatcttaccc atgctctgcaactacctgtcctactggtgggaacgggggcctgagaacctgccccccagc acagggcagtgctgcaccaaggtcacctctgaacacctcagtctcatcctgggcaacatt ctgaaaatcatcaacaacaacctgggcatcgatgaagcctcctggatgaagcgcatcgca gtaataattgtccagaattttcctgtgtatgcacagcccatcatcagcaaagccaggccc gacctgctgagaagccacttcatcccaactctggagaagctgaagaaaaaggctgtcaag accgtgcaggaggaggagcagttgagagccgatggcaaaggggacacccaggaggcggag ctcctcatcctggacgaattcgcggtcctctgccgagatctctatgccttctaccccatg ctgatccgctacgtggacaacaacagatctaactggctgaaaagccctgatgctgattct gaccagctcttccgcatggtggcagaagtctttatcctgtggtgtaaatctcacaacttc aagagggaagagcaaaattttgtgattcagaatgaaattaataatttggcatttttaact ggagacagcaaaagcaagatgtcaaaagccatgcaagtaaagtctggaggacaagaccag gagcggaagaagacaaagcggcggggagacttgtattccatccagacctccctcatcgtg gctgcactcaagaaaatgctgcccattggtttgaatatgtgtactccaggcgaccaggag ctgatctccctcgcaaaatcgcgatacggccatagggacacagatgaagaggtcagagaa catctgcggaacaacttgcacttgcaggaaaagtctgatgacccagctgtaaaatggcag ctgaacctctacaaggatgttctgaagagtgaagaacctttcaatccagaaaagacagtg gagcgtgtacagagaatttcagcagctgtcttccacctggaacaggtggaacagcctttg aggtccaagaaggccgtctggcacaaactactatcaaagcaacggaaacgggcagtggtg gcctgcttcaggatggcccctctctacaacctgcccaggcaccgctctattaacctcttc ctccatggctatcagagattttggatagaaacagaggagtattcctttgaagagaaacta gtacaggatttggctaaatctccaaaggtggaagaggaggaggaggaagagaccgaaaaa caacctgacccactgcatcagataattctctattttagccgcaacgctctcacggagagg agcaaattggaagacgaccctttgtacacctcctattccagcatgatggctaagagttgt caaagtggtgaggacgaagaagaagatgaagacaaggaaaaaacattcgaagagaaggag atggagaagcagaaaaccctgtatcagcaagctcggctgcatgagcgtggtgccgcggag atggtccttcagatgataagcgctagcaaaggtgagatgagccccatggtggttgagacg ctgaagctggggatcgccattctgaacggaggcaatgctggtgtgcaacagaaaatgcta gattacctaaaggagaaaaaggatgctggattctttcaaagcctttctggtcttatgcag tcttgcagtgtccttgatttgaatgcatttgagaggcagaataaagctgaaggcctgggg atggtgactgaagaaggaacactcattgttcgtgaacgtggtgaaaaagtactccagaat gacgagttcacgcgtgatctctttagattcctacagttactttgtgagggacataacagt gactttcagaacttcctgcggactcagatgggtaacaccaccaccgtgaatgtcatcatc agcactgtggactaccttctgcgtctgcaggaatcaatcagtgatttctactggtattat tcagggaaggacatcattgatgaatccggacagcacaatttctccaaagctctggcagtc accaagcagattttcaattctcttacagaatacatccagggcccttgcattggtaatcag cagagcctggctcacagcaggctgtgggacgccgtggttggcttcctccatgtctttgct aatatgcagatgaaactgtctcaggattccagtcagatcgagctgctgaaggaactcttg gatctccttcaggacatggtggtgatgcttctgtccctcctggaagggaatgtggtaaat ggcaccattggcaagcagatggttgacacactggtagaatcatctaccaatgtagaaatg atcttgaaattctttgacatgttcttgaaacttaaagacttaaccagctcagacaccttc aaagaatacgacccagatggtaaaggaattatctccaaaagagaattccagaaggccatg gaagggcaaaaacagtacacgcagtcagagattgactttctcctttcgtgtgcagaagct gatgagaatgacatgtttaattacattgattttgtagaccggttccatgagccggccaag gacatagggtttaatgtggctgtgttattgacaaatctttctgaacacatgccaaacgat tcccggctgaagtgtctgttggacccagcagaaagtgtgctaaattacttcgaaccctac ctaggacgcatcgagatcatgggtggggccaagaaaattgagcgtgtttattttgaaatc agtgagtccagtcgcactcagtgggagaagccccaggtgaaggaatctaagcgacagttc atttttgatgttgtcaacgaaggtggggagcaggaaaagatggagctgtttgtgaacttc tgtgaggacaccatctttgaaatgcagttagcatctcagatctctgaatccgattcagcg gacaggccagaagaggaggaagaagatgaagattcttcttacgtgttagaaatggcgggt gaagaggaggaagacgggtctttcgagccggcctctgcatttgcaatggcctgtgcctct gtgaagaggaacgtcgccgactttctgaagagggcaaccctgaagaacctcaggaagcag tacaggaacgtgaaaaagatgactgcgaaggagctggtgaaggtgctctgctcctttttc tggatgctgttcctggggctgttccagatgctcttcaccatcctgggaggaatctttcag atcctctggagcacagtgttcggagggggcctggtagaaggggcaaagaacatcagagtg accaagatcctgggtgacatgcctgacccaacccaatttggtatccatgatgacactatg gaggctgagagggcagaggtgatggagccaggtatcaccactgaactagtacacttcata aagggggagaagggagatacagatatcatgtcagacctctttggactccacccaaagaaa gagggcagcttaaagcatgggcctgaagtgggtttgggtgacctctcagaaattattggc aaggatgaaccccctacgttagagagtactgtacagaagaagaggaaagctcaggcagca gagatgaaagcagcaaatgaagcagaaggaaaagtagaatccgagaaggcagacatggaa gatggagagaaggaagacaaagccaaagaagaggagcaagccgagtacctgtggacagaa gtgacaaaaaagaagaagcggcggtgtggtcagaaggctgagaagccggaagctttcaca gccaatttctttaaagggctggacatctatcagaccaagttactgcattacctggccagg aatttctacaacctgaggttccttgctctgtttgtagccttcgctatcaacttcatcctg cttttttataaggtcactgaagaacctttagaagaagagacagaggatgttgcaaaccta tggaattcatttaatgacgaggaagaggaagaagcgatggtgttctttgtccttcaggag agcactgggtatatggcaccaacgctgcgggccctggccatcatccacaccatcatctct ctagtctgtgtggtgggctactactgcctgaaggtgcctttggtggtattcaaaagggaa aaagaaatcgccaggaagctggagttcgatggcctatatatcactgaacagccatctgaa gatgacatcaaggggcagtgggaccgcttggtgatcaacacaccatcttttcctaataac tactgggacaagtttgtaaagaggaaggtgatcaacaagtatggagatctctacggagca gagcgcattgctgaacttctgggtttggacaaaaatgctcttgacttcagcccagtagaa gagaccaaagcagaggcagcttctctggtgtcatggctaagttccatagacatgaagtac catatctggaagcttggagttgtgtttactgacaactcctttctctaccttgcctggtat acaaccatgtcagtcctgggccactacaataacttcttctttgctgctcacctgctggat atcgcaatgggcttcaagacactgaggaccattctgtcatctgtaactcacaatggcaaa cagttggttctgacggtcggtctcctggccgtggtggtgtatctctatactgtggtggct ttcaacttcttccgcaagttctacaacaaaagcgaagacgatgacgagcctgatatgaag tgtgacgacatgatgacgtgttaccttttccacatgtacgtgggagtgagagcaggaggt ggcattggtgacgagattgaagaccctgctggtgatccttacgaaatgtatcgcattgtc tttgacattacctttttcttctttgtcattgtcatcttgctggccatcattcaaggtctt attattgatgctttcggagagctaagagaccagcaggaacaagtgcgagaagatatggag accaaatgtttcatctgtgggattggcaatgactactttgacacgacccctcatggtttt gaaacacatacattacaagagcacaacttagccaactacttgttcttcctgatgtatttg attaataaagatgaaacagagcacacgggtcaggaatcttatgtctggaagatgtaccaa gaaaggtgctgggatttcttcccagccggtgactgctttcgtaaacagtatgaagatcag cttggataa

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