Cervus canadensis (wapiti): 122436869 Help Entry 122436869         CDS       T07554                                  Symbol JAK1 Name (RefSeq) tyrosine-protein kinase JAK1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism ccad  Cervus canadensis (wapiti) Pathway ccad01521   EGFR tyrosine kinase inhibitor resistance ccad04151   PI3K-Akt signaling pathway ccad04217   Necroptosis ccad04380   Osteoclast differentiation ccad04550   Signaling pathways regulating pluripotency of stem cells ccad04620   Toll-like receptor signaling pathway ccad04621   NOD-like receptor signaling pathway ccad04630   JAK-STAT signaling pathway ccad04658   Th1 and Th2 cell differentiation ccad04659   Th17 cell differentiation ccad05140   Leishmaniasis ccad05145   Toxoplasmosis ccad05152   Tuberculosis ccad05160   Hepatitis C ccad05161   Hepatitis B ccad05162   Measles ccad05163   Human cytomegalovirus infection ccad05164   Influenza A ccad05165   Human papillomavirus infection ccad05166   Human T-cell leukemia virus 1 infection ccad05167   Kaposi sarcoma-associated herpesvirus infection ccad05168   Herpes simplex virus 1 infection ccad05169   Epstein-Barr virus infection ccad05171   Coronavirus disease - COVID-19 ccad05200   Pathways in cancer ccad05203   Viral carcinogenesis ccad05212   Pancreatic cancer ccad05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:ccad00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     122436869 (JAK1)    04151 PI3K-Akt signaling pathway     122436869 (JAK1)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     122436869 (JAK1)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     122436869 (JAK1)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     122436869 (JAK1)    04621 NOD-like receptor signaling pathway     122436869 (JAK1)    04658 Th1 and Th2 cell differentiation     122436869 (JAK1)    04659 Th17 cell differentiation     122436869 (JAK1)   09158 Development and regeneration    04380 Osteoclast differentiation     122436869 (JAK1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     122436869 (JAK1)    05203 Viral carcinogenesis     122436869 (JAK1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     122436869 (JAK1)   09162 Cancer: specific types    05212 Pancreatic cancer     122436869 (JAK1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     122436869 (JAK1)    05161 Hepatitis B     122436869 (JAK1)    05160 Hepatitis C     122436869 (JAK1)    05171 Coronavirus disease - COVID-19     122436869 (JAK1)    05164 Influenza A     122436869 (JAK1)    05162 Measles     122436869 (JAK1)    05168 Herpes simplex virus 1 infection     122436869 (JAK1)    05163 Human cytomegalovirus infection     122436869 (JAK1)    05167 Kaposi sarcoma-associated herpesvirus infection     122436869 (JAK1)    05169 Epstein-Barr virus infection     122436869 (JAK1)    05165 Human papillomavirus infection     122436869 (JAK1)   09171 Infectious disease: bacterial    05152 Tuberculosis     122436869 (JAK1)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     122436869 (JAK1)    05140 Leishmaniasis     122436869 (JAK1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     122436869 (JAK1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:ccad01001]     122436869 (JAK1) Enzymes [BR:ccad01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      122436869 (JAK1) Protein kinases [BR:ccad01001]  Non-receptor tyrosine kinases   JAK family [OT]    122436869 (JAK1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 FERM_F1 ABC1 SH2 FERM_C_FAK1 Motif Other DBs NCBI-GeneID:  122436869 NCBI-ProteinID:  XP_043317005 LinkDB All DBs Position 2:76031378..76275972 Genome browser AA seq 1157 aa AA seqDB search MQYLNIKEDCSAMAFCAKMRSSKKAEMNLEAPEPGVEVLFYLSDREPLRLGGGEYTAEEL CIRAAQECCISPLCHNLFALYDESTKLWYAPNHSITVDDKTSLRLHYRMRFYFTNWHGTN DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN RFHPNDSGNVLCYEVMVTGNLGIQWRQKPHIVPVEKEKKLKRKKLENKHKKDEEKNKIRE EWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHH YLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTC FEKSEVLGIQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFVLKR CCQPKPREISNLLVATKKAQEWQPVYTMSQLSFDRILKKDITQGEHLGRGTRTHIYSGTL TDYKDDEGTSEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVE NIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLL AREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTT LWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIM RDINKLEEQNPDIVSEKKPTTEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG EQVAVKSLKPESGGNHITDLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSG SLKEYLPKNKNKISLKHQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDF GLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSDS SPMTLFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQHMRKCWEFQPSNRTTF QNLIEGFEALLRSMSTI NT seq 3474 nt NT seq  +upstreamnt  +downstreamnt atgcagtatctaaatataaaagaggactgcagtgccatggccttctgtgctaaaatgagg agctccaagaaggcggagatgaatctggaggcccctgagccgggggtggaagtgctcttc tacctgtcggacagggagcctctccggctgggcggcggagagtacacggcggaggagctg tgcatccgagcggcgcaggagtgctgtatctctcctctgtgtcacaacctctttgccctg tatgacgagagcaccaagctctggtacgctccgaatcacagcatcaccgttgacgacaag acgtcactccggctccactaccggatgaggttctatttcaccaactggcatgggaccaat gacaacgagcaatcagtatggcgacattctccaaagaagcagaaaaatggctatgagaaa aaaaaagttccagatgcaacacctctccttgatgccagctcactggagtatctgtttgct cagggacagtatgatttggtcaaatgcctggctcccattcgagaccccaagacggagcag gatgggcacgacattgagaacgagtgtctgggaatggccgtgctggccatctcccactac gccatgatgaagaagatgcaattgccagaactccccaaggacatcagctacaagcgatat attccagaaacattgaataagtccatcagacagaggaaccttctcaccaggatgcgaata aataatgttttcaaggatttcttaaaggagtttaacaacaagaccatttgcgacagcagc gtgtccacgcatgacctgaaggtgaaatacctggctaccttggaaactttgacaaaacat tatggtgctgaaatatttgagacttccatgctactgatttcatcagaaaatgagatgaat cggttccatccaaatgatagtggaaatgttctctgctatgaagtgatggtgactggaaat cttggaatccagtggagacagaaaccacatattgttcctgttgaaaaggaaaaaaaactg aaacggaaaaaactggaaaataaacacaagaaggatgaggaaaaaaacaaaatccgagaa gagtggaacaatttttcttacttccctgagatcactcacattgtaatcaaggagtctgtg gtcagcattaataagcaggacaacaaaaaaatggagctgaagctctcttcccacgaggag gccttgtccttcgtgtccctggtggacggctatttccggctcacggcagacgcccatcac tacctctgcaccgacgtggctcccccactgatcgtccacaacatacagaatggctgtcat ggtccaatctgcacagaatatgccatcaataagctgcggcaagaaggcagtgaggagggg atgtacgtgctgcggtggagctgcaccgacttcgacaacatcctcatgactgtcacctgc tttgaaaaatctgaggtgctgggtatccagaaacagttcaagaactttcagattgaggtg cagaagggccgctacagcctgcatggctcggaccgcagcttcccgagccttggggacctc atgagccacctaaagaagcagatcctgcgcacggacaacatcagctttgtgctgaagcgc tgctgccagcccaagccccgagaaatctccaatctgctggtggccaccaagaaagcccag gagtggcagcctgtctacaccatgagccagctgagtttcgatcgaatcctcaagaaagat attacgcaaggcgagcaccttgggagaggcacgcggacacacatctactctgggaccctc acagattacaaggatgatgaaggaacttctgaagagaagagaataaaagtcatcctgaag gtcttagaccccagccatagggacatttctctggccttctttgaggcagccagcatgatg aggcaggtttcccataaacacatcgtgtacctctatggggtttgtgtccgagacgtggag aatatcatggtggaagaatttgtggaagggggacccctggatctcttcatgcaccggaaa agtgatgtcctcaccacaccgtggaagtttaaagttgccaaacagctggccagcgccctg agttacttggaggataaagacctggtccatggaaacgtgtgcaccaaaaacctccttctg gcccgtgaggggattgacagtgagtgcggccccttcatcaagctcagcgaccctggcatc cccatcactgtgctctccagacaagagtgcatagaacgaatcccctggatcgctcctgag tgtgttgaagactccaagaacctgagtgtggctgctgacaagtggagctttggaaccaca ctctgggaaatctgctacaatggcgagatccctttgaaagacaagacgctgattgagaaa gagagattctatgaaagccggtgcaggccagtgaccccatcttgtaaggagctagctgac ctgatgacccgctgcatgaactacgaccccaaccagagacccttcttccgagccatcatg agagacatcaataagctggaggagcagaatccagacattgtatcagaaaaaaagccaaca actgaagtggatcccacacattttgaaaagcggttcttaaagaggatccgtgacttggga gagggccactttgggaaggtcgagctctgcaggtatgaccctgagggggacaatacaggg gagcaggtggctgtcaaatccctgaagcccgagagtggagggaaccacatcactgatctg aagaaggagattgaaatcttaagaaacctttaccatgagaacatcgtgaagtataaaggc atctgcacagaagacggtggaaatggtattaagctcatcatggagtttctgccttcaggg agccttaaggaatatcttccaaagaataagaacaaaattagcctcaaacaccagttaaaa tatgctgttcagatttgcaaggggatggactatttgggttctcggcaatatgttcaccgg gacttagcagcaagaaacgtccttgttgagagtgaacaccaagtgaaaattggggacttt ggtctaaccaaagccatcgagactgataaggagtactacacagtcaaggacgaccgggac agccctgtgttttggtatgctccagaatgtttaattcagtgtaagttttatatcgcctct gatgtctggtctttcggagtgactctgcatgagctgcttacttactgtgattcagattcc agtcccatgaccttgttcctgaaaatgataggcccaactcatggccagatgacggtaaca agactcgtgaatacattaaaagaaggaaaacgcttgccgtgtccacctaactgtccagat gaggtttatcaacatatgcgaaagtgttgggaatttcaaccatctaatcggacaaccttt cagaaccttatcgaaggatttgaagcacttctaagaagcatgagtaccatttaa

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