KEGG   PATHWAY: cclu04060
Entry
cclu04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Coregonus clupeaformis (lake whitefish)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
cclu04060  Cytokine-cytokine receptor interaction
cclu04060

Organism
Coregonus clupeaformis (lake whitefish) [GN:cclu]
Gene
121530677  [KO:K04722]
121530758  [KO:K12672]
121530759  [KO:K12672]
121530760  [KO:K12672]
121530762  [KO:K12672]
121530956  [KO:K04666]
121531325  [KO:K05491]
121531330  [KO:K22633]
121531482  [KO:K05164]
121531954  [KO:K05424]
121532664  [KO:K04182]
121532681  il23r; interleukin-23 receptor [KO:K05064]
121532727  [KO:K13072]
121532729  [KO:K21083]
121532744  [KO:K05063]
121532759  [KO:K04193]
121532844  mpl; thrombopoietin receptor [KO:K05082]
121533221  [KO:K05477]
121533348  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
121533361  il12rb2; interleukin-12 receptor subunit beta-2 [KO:K05064]
121533521  amh; muellerian-inhibiting factor [KO:K04665]
121533809  lepr; leptin receptor [KO:K05062]
121534458  [KO:K21283]
121534586  [KO:K05504]
121534595  ackr4a; atypical chemokine receptor 4 [KO:K04186]
121534636  ccr12a; chemokine (C-C motif) receptor 12a [KO:K04179]
121534677  [KO:K13072]
121534694  [KO:K14625]
121534697  [KO:K04193]
121534725  [KO:K04189]
121534732  [KO:K14625]
121534886  crfb16; cytokine receptor family member B16 isoform X1 [KO:K05137]
121534901  [KO:K04667]
121534911  [KO:K04184]
121535276  [KO:K04674] [EC:2.7.11.30]
121535700  [KO:K13596] [EC:2.7.11.30]
121535745  [KO:K05421]
121535993  [KO:K05433]
121536109  [KO:K05171]
121536227  [KO:K04189]
121536271  [KO:K13568] [EC:2.7.11.30]
121536283  [KO:K04304]
121536313  [KO:K04387]
121536314  [KO:K04386]
121536319  [KO:K22687]
121536345  [KO:K05476]
121536404  [KO:K22673]
121536420  [KO:K05135]
121536660  [KO:K05497]
121536712  [KO:K04670] [EC:2.7.11.30]
121536727  [KO:K05171]
121536830  [KO:K13376]
121536834  [KO:K04675] [EC:2.7.11.30]
121536937  [KO:K05162]
121536986  [KO:K04388] [EC:2.7.11.30]
121537249  [KO:K05143]
121537276  [KO:K05152]
121537399  [KO:K13594] [EC:2.7.11.30]
121537533  [KO:K05146]
121537546  [KO:K16621]
121537798  [KO:K05152]
121537892  [KO:K13567] [EC:2.7.11.30]
121538036  [KO:K05425]
121538251  [KO:K05152]
121538264  [KO:K05421]
121538576  [KO:K05168]
121538577  [KO:K05166]
121538763  [KO:K04181]
121538988  [KO:K22674]
121539280  [KO:K13377]
121539441  [KO:K20013]
121539447  [KO:K04662]
121539467  il17a/f1; interleukin 17a/f1 [KO:K05494]
121539881  [KO:K04389]
121539907  [KO:K05060]
121539928  [KO:K05082]
121540453  [KO:K05062]
121541113  [KO:K12671]
121541153  [KO:K04666]
121541186  [KO:K05512]
121541222  tnfsf13; tumor necrosis factor ligand superfamily member 13 isoform X1 [KO:K05475]
121541234  [KO:K13375]
121541304  [KO:K05070]
121541305  [KO:K05070]
121541399  [KO:K05060]
121541591  [KO:K04722]
121541637  [KO:K05080]
121541793  epob; erythropoietin b [KO:K05437]
121541881  [KO:K05077]
121541907  [KO:K13375]
121541958  [KO:K05090] [EC:2.7.10.1]
121542363  [KO:K05148]
121542449  [KO:K05424]
121542581  [KO:K04388] [EC:2.7.11.30]
121542610  [KO:K02583]
121542866  [KO:K04188]
121542867  [KO:K04188]
121542980  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
121542992  cd27; CD27 antigen [KO:K05144]
121542995  [KO:K05417]
121543347  il17ra1a; interleukin 17 receptor A1a [KO:K05164]
121543497  [KO:K13376]
121543778  [KO:K22628]
121543885  [KO:K22628]
121544323  [KO:K05494]
121544481  [KO:K04181]
121544582  [KO:K05090] [EC:2.7.10.1]
121544776  [KO:K04662]
121544784  [KO:K20013]
121544822  [KO:K10033]
121544876  [KO:K26541]
121544909  [KO:K13377]
121545479  [KO:K05165]
121545652  [KO:K05146]
121545715  [KO:K22673]
121545863  [KO:K13567] [EC:2.7.11.30]
121545864  [KO:K13594] [EC:2.7.11.30]
121545895  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
121545972  [KO:K05143]
121546344  [KO:K05173]
121546437  [KO:K05166]
121546438  [KO:K05168]
121546536  [KO:K05168]
121546541  [KO:K16621]
121547066  [KO:K22670]
121547067  [KO:K22674]
121547079  [KO:K05150]
121547106  [KO:K04663]
121547486  [KO:K05153]
121547629  [KO:K05132]
121547632  [KO:K05132]
121547809  [KO:K05080]
121548245  [KO:K05050]
121548627  [KO:K05135]
121548862  [KO:K05157]
121549234  [KO:K04181]
121549246  [KO:K21283]
121549293  il20ra; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136]
121549456  tnfrsf11a; tumor necrosis factor receptor superfamily member 11A [KO:K05147]
121549494  [KO:K16620]
121549502  ccl20b; C-C motif chemokine 20b [KO:K14625]
121549561  [KO:K04184]
121549654  [KO:K13596] [EC:2.7.11.30]
121549724  [KO:K04674] [EC:2.7.11.30]
121549794  [KO:K04721]
121549963  [KO:K04667]
121550005  [KO:K04186]
121550238  [KO:K05414]
121550384  [KO:K05439]
121550643  [KO:K05414]
121550649  [KO:K05414]
121550662  [KO:K05071]
121550670  [KO:K10030]
121550740  [KO:K05071]
121550868  [KO:K05414]
121550907  [KO:K05075]
121550985  [KO:K05079]
121551272  [KO:K05438]
121551442  [KO:K05060]
121551445  mstnb; growth/differentiation factor 8 [KO:K05497]
121551619  [KO:K05069]
121551790  [KO:K13568] [EC:2.7.11.30]
121551808  [KO:K04675] [EC:2.7.11.30]
121551809  [KO:K05477]
121552086  tnfrsf21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
121552622  [KO:K05136]
121552647  [KO:K21283]
121552669  [KO:K13377]
121552828  [KO:K05135]
121552842  [KO:K04181]
121553219  [KO:K10031]
121553598  [KO:K22674]
121553724  [KO:K04673] [EC:2.7.11.30]
121554041  cxcl12b; chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) [KO:K10031]
121554345  [KO:K05474]
121554613  [KO:K05498]
121554954  bmpr2b; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
121555017  [KO:K04388] [EC:2.7.11.30]
121555093  gdf3; protein DVR-1 [KO:K22672]
121555130  [KO:K22687]
121555172  [KO:K04670] [EC:2.7.11.30]
121555479  [KO:K02582]
121555809  [KO:K05061]
121555826  [KO:K02582]
121555914  [KO:K04189]
121556169  [KO:K13377]
121556178  [KO:K05135]
121556225  [KO:K05050]
121556728  [KO:K04388] [EC:2.7.11.30]
121556910  [KO:K02583]
121557239  [KO:K05439]
121557246  [KO:K04193]
121557983  inha; inhibin alpha chain [KO:K05500]
121558698  [KO:K05155]
121560083  [KO:K04671] [EC:2.7.11.30]
121560174  ebi3; interleukin-27 subunit beta [KO:K24476]
121560230  [KO:K05152]
121560233  [KO:K05152]
121560263  [KO:K04723]
121560373  [KO:K21283]
121560509  [KO:K05152]
121560511  [KO:K05152]
121560512  [KO:K05152]
121560554  acvr1l; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
121561428  [KO:K10030]
121561681  inhbab; inhibin subunit beta Ab [KO:K04667]
121561855  [KO:K05414]
121562235  il10ra; interleukin-10 receptor subunit alpha [KO:K05134]
121562501  [KO:K05497]
121562507  [KO:K04670] [EC:2.7.11.30]
121563972  [KO:K04671] [EC:2.7.11.30]
121564507  [KO:K05414]
121564802  [KO:K05414]
121564805  [KO:K05414]
121565258  [KO:K05050]
121565900  [KO:K05050]
121566279  tnfb; tumor necrosis factor b (TNF superfamily, member 2) [KO:K03156]
121566761  [KO:K04182]
121566924  [KO:K05156]
121567031  [KO:K05438]
121567275  [KO:K04723]
121567690  [KO:K13375]
121568028  [KO:K05155]
121568141  relt; tumor necrosis factor receptor superfamily member 19L [KO:K05156]
121568185  [KO:K05438]
121568225  [KO:K10030]
121568238  [KO:K21283]
121568250  [KO:K05134]
121568332  [KO:K06854]
121568361  [KO:K04190]
121568369  [KO:K10031]
121568492  [KO:K05406]
121568888  [KO:K02583]
121569120  [KO:K05075]
121569133  [KO:K04674] [EC:2.7.11.30]
121569162  [KO:K16620]
121569187  [KO:K13596] [EC:2.7.11.30]
121569305  [KO:K04721]
121569416  [KO:K05079]
121569702  [KO:K05414]
121569703  [KO:K05414]
121569713  [KO:K05438]
121569779  [KO:K04673] [EC:2.7.11.30]
121569863  ackr4b; atypical chemokine receptor 4b [KO:K04186]
121570067  [KO:K04180]
121570246  [KO:K05414]
121570247  [KO:K05414]
121570252  [KO:K04738]
121570376  [KO:K05477]
121570436  [KO:K04179]
121570437  [KO:K04179]
121570467  [KO:K14625]
121570468  [KO:K14625]
121570483  [KO:K05147]
121570517  [KO:K10030]
121570564  [KO:K05414]
121570566  [KO:K05414]
121570567  [KO:K05414]
121570568  [KO:K05414]
121570573  [KO:K05414]
121570574  [KO:K05414]
121570575  [KO:K05414]
121570576  [KO:K05414]
121570579  [KO:K05414]
121570585  [KO:K05069]
121570599  [KO:K05439]
121570609  [KO:K04667]
121570628  [KO:K04184]
121570664  [KO:K04179]
121570666  [KO:K04179]
121571030  rell1; RELT-like protein 1 [KO:K26541]
121571445  [KO:K04388] [EC:2.7.11.30]
121571519  [KO:K16622]
121571659  [KO:K04304]
121571697  [KO:K05492]
121571731  [KO:K05162]
121572162  [KO:K05437]
121572451  [KO:K05498]
121572813  [KO:K05476]
121572939  [KO:K05143]
121572974  [KO:K05076]
121572986  [KO:K05474]
121573010  [KO:K03156]
121573028  il6; interleukin-6 [KO:K05405]
121573342  cntfr; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
121573343  [KO:K05056]
121573416  prlra; prolactin receptor a [KO:K05081]
121573840  [KO:K13578] [EC:2.7.11.30]
121574057  [KO:K05425]
121574336  [KO:K05155]
121574365  eda2r; tumor necrosis factor receptor superfamily member 27 isoform X1 [KO:K05163]
121574366  [KO:K05480]
121574391  [KO:K22670]
121574395  [KO:K05072]
121574787  [KO:K22687]
121574836  [KO:K05141]
121574982  [KO:K16621]
121575100  [KO:K04663]
121575148  [KO:K22679]
121575257  [KO:K13567] [EC:2.7.11.30]
121575403  [KO:K05453]
121575481  [KO:K05166]
121575824  [KO:K02582]
121575974  [KO:K05443]
121576045  gdf5; growth/differentiation factor 5 [KO:K04664]
121576054  ackr3b; atypical chemokine receptor 3b [KO:K04304]
121576802  [KO:K13072]
121576868  [KO:K05063]
121577229  [KO:K04193]
121577279  [KO:K22633]
121577282  il17c; interleukin-17C [KO:K05491]
121577307  [KO:K21083]
121577616  [KO:K13567] [EC:2.7.11.30]
121577827  [KO:K22679]
121578067  [KO:K05166]
121578227  [KO:K16621]
121578320  [KO:K22687]
121578433  tnfrsf1b; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141]
121578587  [KO:K05443]
121578588  [KO:K05443]
121578648  il19l; interleukin 19 like [KO:K22667]
121578716  [KO:K02582]
121578725  [KO:K05142]
121578985  [KO:K05480]
121579522  il13ra2; interleukin-13 receptor subunit alpha-2 isoform X1 [KO:K05077]
121579543  [KO:K13375]
121579657  [KO:K05090] [EC:2.7.10.1]
121579849  [KO:K05090] [EC:2.7.10.1]
121579984  [KO:K22629]
121580136  [KO:K05438]
121580153  [KO:K05425]
121580333  [KO:K05437]
121580573  [KO:K13596] [EC:2.7.11.30]
121580585  [KO:K04184]
121580801  [KO:K04186]
121580966  [KO:K04674] [EC:2.7.11.30]
121581373  [KO:K21283]
121581462  [KO:K05504]
121581516  [KO:K04179]
121581559  [KO:K04189]
121581563  [KO:K14625]
121581601  [KO:K13072]
121581688  [KO:K05406]
121581895  [KO:K05080]
121581972  [KO:K05060]
121581974  [KO:K22630]
121582107  [KO:K21283]
121582118  [KO:K05150]
121582171  [KO:K13578] [EC:2.7.11.30]
121582190  [KO:K05058]
121582194  [KO:K05072]
121582555  [KO:K05080]
121582575  [KO:K22674]
121582607  [KO:K04722]
121583060  ngfrb; nerve growth factor receptor b isoform X1 [KO:K02583]
121583063  [KO:K05408]
121583109  [KO:K04390]
121583198  [KO:K05478]
121583200  [KO:K05478]
121583224  [KO:K22670]
121583299  ccl19b; C-C motif chemokine 19b [KO:K05512]
121583312  ccl27b; C-C motif chemokine 27b [KO:K05513]
121583395  [KO:K05081]
121583581  il16; pro-interleukin-16 [KO:K22628]
121583615  [KO:K05059]
121583616  [KO:K05056]
121583980  [KO:K04666]
121584051  bmp3; bone morphogenetic protein 3 [KO:K05496]
121584077  si:dkey-88e18.2; interleukin-12 subunit beta [KO:K05425]
121584205  [KO:K22670]
121584213  hdr; hematopoietic death receptor [KO:K04722]
121584229  [KO:K05513]
121584365  lifra; LOW QUALITY PROTEIN: LIF receptor subunit alpha a [KO:K05058]
121584379  [KO:K13578] [EC:2.7.11.30]
121584465  [KO:K10032]
121584668  [KO:K05081]
121585131  [KO:K05080]
121585177  [KO:K04519]
121585473  [KO:K05148]
121585487  [KO:K04188]
121585488  [KO:K04188]
121585489  [KO:K04188]
121585503  [KO:K05144]
121585513  [KO:K05417]
121585522  gdf6b; growth/differentiation factor 6-B [KO:K20012]
121585646  [KO:K05405]
121585680  [KO:K03156]
121585681  [KO:K03156]
121585776  [KO:K05143]
121585879  [KO:K20012]
121585906  [KO:K13376]
121586084  [KO:K05425]
121586213  [KO:K03158]
121586242  [KO:K04179]
121586243  [KO:K04180]
121586338  [KO:K04388] [EC:2.7.11.30]
121586403  [KO:K16622]
121586724  [KO:K05061]
121586959  [KO:K22687]
121587208  [KO:K05496]
121587264  [KO:K22670]
121587276  [KO:K04519]
121587304  [KO:K12672]
121587305  [KO:K10032]
121587315  ndr2; nodal-related 2 [KO:K04666]
123481104  [KO:K05152]
123481460  [KO:K10033]
123481844  [KO:K05152]
123482511  [KO:K05414]
123482934  [KO:K05437]
123483423  [KO:K20012]
123484576  [KO:K05439]
123486065  [KO:K04670] [EC:2.7.11.30]
123488375  [KO:K02583]
123488541  [KO:K16595]
123490248  [KO:K04723]
123491305  [KO:K02583]
123492096  [KO:K04664]
123492681  ndr1; nodal-related 1 [KO:K04666]
123493105  [KO:K12672]
Reference
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
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