KEGG   PATHWAY: chx04510
Entry
chx04510                    Pathway                                
Name
Focal adhesion - Capra hircus (goat)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
chx04510  Focal adhesion
chx04510

Other DBs
GO: 0005925
Organism
Capra hircus (goat) [GN:chx]
Gene
100860743  COL2A1; collagen alpha-1(II) chain [KO:K19719]
100860749  CAV1; caveolin-1 isoform X1 [KO:K06278]
100860805  SPP1; osteopontin precursor [KO:K06250]
100860828  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
100860836  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
100860837  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
100860838  IGF1; insulin-like growth factor I precursor [KO:K05459]
100860883  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100860904  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100860940  COL1A2; collagen alpha-2(I) chain [KO:K06236]
100860957  VEGFA; vascular endothelial growth factor A isoform 1 precursor [KO:K05448]
100860971  THBS1; thrombospondin-1 isoform X1 [KO:K16857]
100860973  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
100861087  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100861163  MYL11; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
100861165  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100861216  VTN; vitronectin [KO:K06251]
100861254  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
102168376  LAMB3; laminin subunit beta-3 [KO:K06244]
102168391  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102168651  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
102168934  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102169297  PGF; placenta growth factor isoform X1 [KO:K16859]
102169417  ITGB3; integrin beta-3 [KO:K06493]
102169643  COL6A3; collagen alpha-3(VI) chain isoform X5 [KO:K06238]
102169650  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102169839  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
102169956  SHC2; LOW QUALITY PROTEIN: SHC-transforming protein 2 [KO:K17447]
102170035  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
102170125  PARVG; gamma-parvin [KO:K06275]
102170129  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
102170135  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
102170256  LAMC1; laminin subunit gamma-1 [KO:K05635]
102170356  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
102170408  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102170540  LAMC2; laminin subunit gamma-2 [KO:K06246]
102170917  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
102170926  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
102170985  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
102171022  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
102171074  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
102171079  COL4A1; LOW QUALITY PROTEIN: collagen alpha-1(IV) chain [KO:K06237]
102171347  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
102171628  PARVA; alpha-parvin isoform X1 [KO:K06275]
102171801  LAMA5; laminin subunit alpha-5 [KO:K06240]
102172114  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
102172198  ITGA2; integrin alpha-2 [KO:K06481]
102172761  ITGA1; integrin alpha-1 [KO:K06480]
102172767  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102172966  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
102173438  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102173485  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
102173608  ITGB5; integrin beta-5 [KO:K06588]
102173952  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
102174007  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102174051  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102174073  ITGA9; integrin alpha-9 [KO:K06585]
102174079  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
102174268  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
102174330  CRK; adapter molecule crk isoform X1 [KO:K04438]
102174360  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
102174446  TNXB; tenascin-X isoform X1 [KO:K06252]
102174457  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
102174543  RAP1B; ras-related protein Rap-1b [KO:K07836]
102174559  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
102174891  [KO:K12757]
102174902  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
102175206  CRKL; crk-like protein [KO:K04438]
102175280  PARVB; beta-parvin [KO:K06275]
102175348  [KO:K12757]
102175583  TLN2; talin-2 isoform X1 [KO:K06271]
102175843  IBSP; bone sialoprotein 2 [KO:K06253]
102175984  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102176003  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
102176334  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
102176363  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
102176451  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
102176581  CAV2; caveolin-2 isoform X1 [KO:K12958]
102176587  ITGA5; integrin alpha-5 [KO:K06484]
102176601  FLNA; filamin-A isoform X1 [KO:K04437]
102176661  LAMB1; laminin subunit beta-1 [KO:K05636]
102176677  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
102176727  CHAD; chondroadherin [KO:K06248]
102176802  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
102176919  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
102176930  RAP1A; ras-related protein Rap-1A [KO:K04353]
102176947  COL4A5; collagen alpha-5(IV) chain isoform X2 [KO:K06237]
102176966  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
102177024  MYL10; myosin regulatory light chain 10 [KO:K12756]
102177259  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
102177274  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
102177428  VAV1; proto-oncogene vav [KO:K05730]
102177440  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
102177551  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102177814  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
102178060  ITGB1; integrin beta-1 precursor [KO:K05719]
102178087  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
102178097  PXN; paxillin isoform X1 [KO:K05760]
102178149  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
102178401  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
102178569  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
102178574  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
102178669  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
102179198  TNC; tenascin isoform X1 [KO:K06252]
102179246  [KO:K06243]
102179343  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102179669  TLN1; talin-1 isoform X1 [KO:K06271]
102179673  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
102179674  THBS2; thrombospondin-2 [KO:K04659]
102179675  THBS4; thrombospondin-4 [KO:K04659]
102179773  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
102179802  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
102179831  ACTB; actin, cytoplasmic 1 [KO:K05692]
102179873  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
102180190  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
102180480  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
102180657  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
102180827  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
102180890  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
102181064  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
102181169  RHOA; transforming protein RhoA [KO:K04513]
102181186  MET; hepatocyte growth factor receptor isoform X2 [KO:K05099] [EC:2.7.10.1]
102181217  PAK5; serine/threonine-protein kinase PAK 7 [KO:K05736] [EC:2.7.11.1]
102181227  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
102181229  TNN; tenascin-N [KO:K06252]
102181454  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
102181525  TNR; tenascin-R [KO:K06252]
102181571  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
102181692  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
102181695  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
102181773  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
102181980  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
102181989  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102182147  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
102182530  PAK4; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
102182645  FN1; fibronectin isoform X1 [KO:K05717]
102182774  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102182890  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
102183190  ITGA4; integrin alpha-4 [KO:K06483]
102183288  HGF; hepatocyte growth factor isoform X2 [KO:K05460]
102183294  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
102183372  [KO:K06243]
102183402  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
102183451  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
102183869  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
102184154  SOS2; son of sevenless homolog 2 [KO:K03099]
102184232  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
102184426  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
102184914  LAMC3; laminin subunit gamma-3 [KO:K06247]
102184966  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
102185042  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102185146  ZYX; zyxin [KO:K06273]
102185378  COL9A1; LOW QUALITY PROTEIN: collagen alpha-1(IX) chain [KO:K08131]
102185415  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
102185423  JUN; transcription factor AP-1 [KO:K04448]
102185499  ITGA3; integrin alpha-3 [KO:K06482]
102185645  VEGFD; vascular endothelial growth factor D [KO:K05449]
102185660  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102185710  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
102185891  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102186040  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102186530  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
102186592  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X2 [KO:K00889] [EC:2.7.1.68]
102186668  HRAS; GTPase HRas isoform X1 [KO:K02833]
102186825  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
102187050  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
102187521  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102187630  FLNB; filamin-B isoform X6 [KO:K27392]
102187707  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
102187813  ITGAV; integrin alpha-V precursor [KO:K06487]
102188539  ITGB6; integrin beta-6 precursor [KO:K06589]
102188580  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
102188638  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102188710  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102188740  VCL; vinculin isoform X1 [KO:K05700]
102188824  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102189099  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
102189153  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
102189645  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
102189677  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
102189719  CAV3; caveolin-3 [KO:K12959]
102189826  VEGFC; vascular endothelial growth factor C [KO:K05449]
102189930  BAD; bcl2-associated agonist of cell death [KO:K02158]
102190083  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
102190117  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
102190283  EMP2; epithelial membrane protein 2 [KO:K26256]
102190364  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
102190470  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
102190520  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X4 [KO:K04368] [EC:2.7.12.2]
102190641  MYLK; LOW QUALITY PROTEIN: myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
102190652  THBS3; thrombospondin-3 [KO:K04659]
102190835  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
102191085  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
102191119  VWF; von Willebrand factor [KO:K03900]
102191175  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
102191301  ITGB8; integrin beta-8 isoform X2 [KO:K06591]
102191378  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
102191742  CTNNB1; catenin beta-1 [KO:K02105]
106502173  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
108633195  [KO:K06237]
108634775  [KO:K06236]
108636055  EMP1; epithelial membrane protein 1 [KO:K26255]
108638619  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
chx04010  MAPK signaling pathway
chx04060  Cytokine-cytokine receptor interaction
chx04070  Phosphatidylinositol signaling system
chx04110  Cell cycle
chx04151  PI3K-Akt signaling pathway
chx04310  Wnt signaling pathway
chx04512  ECM-receptor interaction
chx04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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