KEGG   Canis lupus dingo (dingo): 112662621
Entry
112662621         CDS       T08371                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
clud  Canis lupus dingo (dingo)
Pathway
clud00562  Inositol phosphate metabolism
clud01100  Metabolic pathways
clud01521  EGFR tyrosine kinase inhibitor resistance
clud01522  Endocrine resistance
clud01524  Platinum drug resistance
clud04012  ErbB signaling pathway
clud04014  Ras signaling pathway
clud04015  Rap1 signaling pathway
clud04024  cAMP signaling pathway
clud04062  Chemokine signaling pathway
clud04066  HIF-1 signaling pathway
clud04068  FoxO signaling pathway
clud04070  Phosphatidylinositol signaling system
clud04071  Sphingolipid signaling pathway
clud04072  Phospholipase D signaling pathway
clud04140  Autophagy - animal
clud04150  mTOR signaling pathway
clud04151  PI3K-Akt signaling pathway
clud04152  AMPK signaling pathway
clud04210  Apoptosis
clud04211  Longevity regulating pathway
clud04213  Longevity regulating pathway - multiple species
clud04218  Cellular senescence
clud04360  Axon guidance
clud04370  VEGF signaling pathway
clud04380  Osteoclast differentiation
clud04510  Focal adhesion
clud04550  Signaling pathways regulating pluripotency of stem cells
clud04611  Platelet activation
clud04613  Neutrophil extracellular trap formation
clud04620  Toll-like receptor signaling pathway
clud04625  C-type lectin receptor signaling pathway
clud04630  JAK-STAT signaling pathway
clud04650  Natural killer cell mediated cytotoxicity
clud04660  T cell receptor signaling pathway
clud04662  B cell receptor signaling pathway
clud04664  Fc epsilon RI signaling pathway
clud04666  Fc gamma R-mediated phagocytosis
clud04668  TNF signaling pathway
clud04670  Leukocyte transendothelial migration
clud04722  Neurotrophin signaling pathway
clud04725  Cholinergic synapse
clud04750  Inflammatory mediator regulation of TRP channels
clud04810  Regulation of actin cytoskeleton
clud04910  Insulin signaling pathway
clud04914  Progesterone-mediated oocyte maturation
clud04915  Estrogen signaling pathway
clud04917  Prolactin signaling pathway
clud04919  Thyroid hormone signaling pathway
clud04923  Regulation of lipolysis in adipocytes
clud04926  Relaxin signaling pathway
clud04929  GnRH secretion
clud04930  Type II diabetes mellitus
clud04931  Insulin resistance
clud04932  Non-alcoholic fatty liver disease
clud04933  AGE-RAGE signaling pathway in diabetic complications
clud04935  Growth hormone synthesis, secretion and action
clud04960  Aldosterone-regulated sodium reabsorption
clud04973  Carbohydrate digestion and absorption
clud05010  Alzheimer disease
clud05017  Spinocerebellar ataxia
clud05020  Prion disease
clud05100  Bacterial invasion of epithelial cells
clud05132  Salmonella infection
clud05135  Yersinia infection
clud05142  Chagas disease
clud05146  Amoebiasis
clud05160  Hepatitis C
clud05161  Hepatitis B
clud05162  Measles
clud05163  Human cytomegalovirus infection
clud05164  Influenza A
clud05165  Human papillomavirus infection
clud05166  Human T-cell leukemia virus 1 infection
clud05167  Kaposi sarcoma-associated herpesvirus infection
clud05168  Herpes simplex virus 1 infection
clud05169  Epstein-Barr virus infection
clud05170  Human immunodeficiency virus 1 infection
clud05171  Coronavirus disease - COVID-19
clud05200  Pathways in cancer
clud05203  Viral carcinogenesis
clud05205  Proteoglycans in cancer
clud05206  MicroRNAs in cancer
clud05207  Chemical carcinogenesis - receptor activation
clud05208  Chemical carcinogenesis - reactive oxygen species
clud05210  Colorectal cancer
clud05211  Renal cell carcinoma
clud05212  Pancreatic cancer
clud05213  Endometrial cancer
clud05214  Glioma
clud05215  Prostate cancer
clud05218  Melanoma
clud05220  Chronic myeloid leukemia
clud05221  Acute myeloid leukemia
clud05222  Small cell lung cancer
clud05223  Non-small cell lung cancer
clud05224  Breast cancer
clud05225  Hepatocellular carcinoma
clud05226  Gastric cancer
clud05230  Central carbon metabolism in cancer
clud05231  Choline metabolism in cancer
clud05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
clud05415  Diabetic cardiomyopathy
clud05417  Lipid and atherosclerosis
clud05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:clud00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    112662621 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    112662621 (PIK3CA)
   04014 Ras signaling pathway
    112662621 (PIK3CA)
   04015 Rap1 signaling pathway
    112662621 (PIK3CA)
   04370 VEGF signaling pathway
    112662621 (PIK3CA)
   04630 JAK-STAT signaling pathway
    112662621 (PIK3CA)
   04668 TNF signaling pathway
    112662621 (PIK3CA)
   04066 HIF-1 signaling pathway
    112662621 (PIK3CA)
   04068 FoxO signaling pathway
    112662621 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    112662621 (PIK3CA)
   04072 Phospholipase D signaling pathway
    112662621 (PIK3CA)
   04071 Sphingolipid signaling pathway
    112662621 (PIK3CA)
   04024 cAMP signaling pathway
    112662621 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    112662621 (PIK3CA)
   04152 AMPK signaling pathway
    112662621 (PIK3CA)
   04150 mTOR signaling pathway
    112662621 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    112662621 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    112662621 (PIK3CA)
   04218 Cellular senescence
    112662621 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    112662621 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    112662621 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    112662621 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    112662621 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    112662621 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    112662621 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    112662621 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    112662621 (PIK3CA)
   04660 T cell receptor signaling pathway
    112662621 (PIK3CA)
   04662 B cell receptor signaling pathway
    112662621 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    112662621 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    112662621 (PIK3CA)
   04670 Leukocyte transendothelial migration
    112662621 (PIK3CA)
   04062 Chemokine signaling pathway
    112662621 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    112662621 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    112662621 (PIK3CA)
   04929 GnRH secretion
    112662621 (PIK3CA)
   04915 Estrogen signaling pathway
    112662621 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    112662621 (PIK3CA)
   04917 Prolactin signaling pathway
    112662621 (PIK3CA)
   04926 Relaxin signaling pathway
    112662621 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    112662621 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    112662621 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    112662621 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    112662621 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    112662621 (PIK3CA)
   04722 Neurotrophin signaling pathway
    112662621 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    112662621 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    112662621 (PIK3CA)
   04380 Osteoclast differentiation
    112662621 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    112662621 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    112662621 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112662621 (PIK3CA)
   05206 MicroRNAs in cancer
    112662621 (PIK3CA)
   05205 Proteoglycans in cancer
    112662621 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    112662621 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    112662621 (PIK3CA)
   05203 Viral carcinogenesis
    112662621 (PIK3CA)
   05230 Central carbon metabolism in cancer
    112662621 (PIK3CA)
   05231 Choline metabolism in cancer
    112662621 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    112662621 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    112662621 (PIK3CA)
   05212 Pancreatic cancer
    112662621 (PIK3CA)
   05225 Hepatocellular carcinoma
    112662621 (PIK3CA)
   05226 Gastric cancer
    112662621 (PIK3CA)
   05214 Glioma
    112662621 (PIK3CA)
   05221 Acute myeloid leukemia
    112662621 (PIK3CA)
   05220 Chronic myeloid leukemia
    112662621 (PIK3CA)
   05218 Melanoma
    112662621 (PIK3CA)
   05211 Renal cell carcinoma
    112662621 (PIK3CA)
   05215 Prostate cancer
    112662621 (PIK3CA)
   05213 Endometrial cancer
    112662621 (PIK3CA)
   05224 Breast cancer
    112662621 (PIK3CA)
   05222 Small cell lung cancer
    112662621 (PIK3CA)
   05223 Non-small cell lung cancer
    112662621 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    112662621 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    112662621 (PIK3CA)
   05161 Hepatitis B
    112662621 (PIK3CA)
   05160 Hepatitis C
    112662621 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    112662621 (PIK3CA)
   05164 Influenza A
    112662621 (PIK3CA)
   05162 Measles
    112662621 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    112662621 (PIK3CA)
   05163 Human cytomegalovirus infection
    112662621 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    112662621 (PIK3CA)
   05169 Epstein-Barr virus infection
    112662621 (PIK3CA)
   05165 Human papillomavirus infection
    112662621 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    112662621 (PIK3CA)
   05135 Yersinia infection
    112662621 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    112662621 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    112662621 (PIK3CA)
   05142 Chagas disease
    112662621 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    112662621 (PIK3CA)
   05017 Spinocerebellar ataxia
    112662621 (PIK3CA)
   05020 Prion disease
    112662621 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    112662621 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    112662621 (PIK3CA)
   05415 Diabetic cardiomyopathy
    112662621 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    112662621 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    112662621 (PIK3CA)
   04931 Insulin resistance
    112662621 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    112662621 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    112662621 (PIK3CA)
   01524 Platinum drug resistance
    112662621 (PIK3CA)
   01522 Endocrine resistance
    112662621 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:clud04131]
    112662621 (PIK3CA)
Enzymes [BR:clud01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     112662621 (PIK3CA)
Membrane trafficking [BR:clud04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    112662621 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 112662621
NCBI-ProteinID: XP_025306945
Ensembl: ENSCAFG00020023109
LinkDB
Position
34:12599486..12679671
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgacgttagaatgcctccgtgaggct
acattaataactataaagcatgaattatttaaagaagcaagaaagtaccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacggctttgtgaccttcggctttttcaaccctttttaaaa
gtaattgagccagtaggcaaccgagaagaaaagatcctcaatcgagaaattggttttgct
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttcgggatcttaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaaacagaagtatactctgaaaatcaaccatgactgtgttccagaacaagta
attgctgaagcaatcagaaaaaaaactagaagtatgttgctatcatctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtatgtggatgtgatgaatac
ttccttgaaaaatatcctctaagtcagtataagtacataagaagctgtataatgcttgga
aggatgcccaatttgatgttgatggctaaagaaagcctttactcccaattgccaatggac
tgtttcacaatgccatcttattccagacgcatctccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagcgcactcagaataaaaatcctttgt
gcaacctatgtaaatgtaaatattcgagacattgacaagatttatgttcgaacaggtatc
tatcatggaggagaacccttatgtgataatgttaacactcaaagagtaccttgttctaat
cccaggtggaatgaatggctaaattacgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctctgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactgggtcaaatccaaataaagaaactccatgcttagagttggagtttgactggttc
agcagtgtggtaaagttcccagatatgtcagtgattgaagagcatgccaactggtcggtg
tctcgggaagcaggatttagttattcccatgcaggactgagtaacagactggctagagac
aacgaattaagagaaaatgataaagaacagctccgagcaatttgtacccgagatcctctc
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccctgaaattctacccaaactgcttctgtccgttaaatggaattctagagatgaagta
gctcagatgtactgcttagtaaaagattggcctccaatcaaacctgaacaagctatggag
cttctggactgtaattacccagatcctatggttcgaggttttgctgttcggtgcttggaa
aaatacttaacagatgacaagctttctcagtacctaattcagctagtacaggtcctaaaa
tacgaacaatatttggataacctgcttgtgagatttttactcaagaaagcattgactaat
caaaggattgggcattttttcttttggcatttaaaatctgagatgcacaataaaacggtt
agtcagaggtttggcctgcttttggagtcctattgccgtgcttgtgggatgtatttgaag
cacctaaataggcaagttgaggctatggaaaagctcattaacttaactgacattctcaaa
caagagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgcgg
cgaccagatttcatggatgctctacaaggttttctatctcctctaaatcctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacgacaagatatgctaacacttcaaataattcgcattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctgtca
atcggtgactgtgtgggacttattgaggtggtgcgaaattctcacactattatgcagatt
cagtgcaaaggtggcctgaaaggtgcactgcagttcaacagccacacactacaccagtgg
ctcaaagacaagaacaaaggagaaatatatgatgcagccattgacctgttcacacgttca
tgtgctggatattgtgttgctaccttcattttgggaattggagatcgtcacaatagtaac
atcatggttaaagatgatggacaactgtttcatatagattttggacactttttggaccat
aagaagaaaaaatttggttataaacgggaacgtgtgccatttgttttgacacaggatttc
ttaatagtgattagtaaaggagcccaggaatgcacaaaaacaagagaatttgagaggttt
caggagatgtgttacaaggcttacctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgaacaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
accattaagcagcatgctttgaactga

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