Colossoma macropomum (tambaqui): 118815642 Help Entry 118815642         CDS       T09004                                  Symbol ryr3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism cmao  Colossoma macropomum (tambaqui) Pathway cmao04020   Calcium signaling pathway cmao04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:cmao00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     118815642 (ryr3)    04020 Calcium signaling pathway     118815642 (ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:cmao04040]     118815642 (ryr3) Ion channels [BR:cmao04040]  Voltage-gated cation channels   Ryanodine receptor    118815642 (ryr3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 Ins145_P3_rec SPRY MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_6 EF-hand_1 EF-hand_8 Motif Other DBs NCBI-GeneID:  118815642 NCBI-ProteinID:  XP_036437797 LinkDB All DBs Position Unknown AA seq 4856 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCVATIQKENRKFCLSAEGLGNRLCYLEPTSEAKYVPP DLCICNFVLEQSLSVRALQEMLANTGPNGEGNPDHERWAGQGGGHRTLLYGHAILLRHSF SGMYLACLKTSRSLTDKLSFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRIGDDLILVS VSSERYLHLSMSNGNIQVDASFMQTLWNVQPTCSGSNVAVGYLRGGHVIRLFHGHDESMT IPGSDQSEEQQRLVNYEAGKGGSKARSLWRLEPLRISWSGSHMRWGQPFRLRHLSTGHYL GQTEDRGLVLVDREKSDTTSTSFCFRPSKEKVDSGPKRDIDGMGVAEIKYGDSVCFIMHV ATGLWLSYQAPDAKSSRLGLLKRRAFLYPEGHMDDGLILQLCQHEESRAARIIRNTTQLF TQFIRGLDALKGEKASEVSLPVGEVLQTLNDLIAYFQQPDSELDHEEKQRQLRSLIKRQD LFKEEGMLTLVSVCIDRLNVYNSAAEFEELAGEEAAEAWKDILNLLYELLAALIRGNRPN CTQFSRKLDWLVSKLERLESSSGILEALHCILTESPEALNIIQKDHIKSIISLLYKHGRN HKILDILCSLCVCNGVAVRANQNFIAEHLLPRRDVLLQTQLVNDVQSMRPNIFLGMSEGS AQYKKWYYELIIDQVDHFVTSSPTHLRVGWATTKGYAPYPGGGEGWGGNGVGDDLYSYSF DGLHLWSGRIPRAVASINQHLLNSDDVVSCCLDLGAPSMSFRINGQPVQGMFEDFNTDGF FFPVVSFSAGVKVRFLLGGRHGDFKFMPPAGYAPCYEALLPKEKMRVEPVKEYKRDLEGV RDLLGTTQFLSQASFIPIPVNTSQIVLPPHLENVRDKLAENIHELWGMNKIELGWTYGKV RDDNKRQHPCLVDFSKLPETEKNYNLQMSTETLKTLLALGCHVVHINANAEEDLKKIKLP KDYMMSNGYKPSPLELSDVKLTPGQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKSK RNPRLVPYALLDERTKKSNRDSLREAIRTLIGYGYNIDPPDQETAHVVEKLSVENIRFFR VEKTYAVKSGKWYFEFEAVTGGEMCVGWARPGCRPDIDLGMDDQAFVFDGYRGRRVHMGS HFFGRTWNKGDVVGCMINMEDKSMIFTLNGEILITNKGSELCFADFETEDGFIPVCSLGL SQIGHMNLGKDANTFKYYTMCGLQEGFEPFAVNMNREVPMWFSKRLPTFVNVPEDHEHIE VTRIDGTVDTPPCLKVTHKTFGTQASNTDMIYCRLSMPVEFYPGPRKVTNINEVIADDQK AKKDDSGKIDYKSITKYFYSVRVFAGQDPASVWIGWVTPDYHYYSKNFSLSKVRTVTVTL GDERGRVHESVRRSNCYMVCAGEISSSSTGRNNIDLEIGCHIDLDSGLVSFTANGKELPT AYQVEPNTKLFPAVFVEPTSPNLFQFEFPKIQDAMPLSSAIFKSLHSNPEPQCPPRLDVQ TIVAVLWSRMPNTFLSVETARVSERHGWVVQCLEPLQMMAVHIPEENRCLDIMELSEHED LRQFHYHTLKLYCALCALGNTRVAHALCSHLDQSQLLYTIDNQYLSGQLREGFYDVLISI HLETAKEAHLMMNNEFIIPVTDETRSIRLFPDNSKRHSLPGVGLSTSLAPRLNFSPPCFM ITKREYLYSPQLPLRILKEKAISMLTEAVQGGGAHIRDPVGGSVAYQFVPILKLIGTLLI MGALSSEEVRLILLLIEPNVFTESKEEELQLALPEEAAEKEETSSNEEKTVEAGEEESKE SKQAPKGLLEKSLPESVKRQMCELLHYFCDCELKQRIEAIVAFSDSFVAKLQYNQKFRYN ELMQALNMSAAVTAKKTKEFRSPPQEQINMLLNFSTGEDCPCPEELQEELEAFHDDLRLH CGIPMEEEEEEQDTSVKGRLLSLLYKIKGRPQKTEEEPSEQEQAAPTNLKELISQTMVSW AQEHTIQDPELVRSMFSLLRRQYDGIGELLRAMRKSYTISEKSVQDAINLLASLGQIRSL LSVRMGEEEGQLMIDGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKSKEIAF PKVVASCCRFLCYFCRISRENQKAMFDHLSYLLENSSVGLACPAMRGSTPLDVAASSVMD NNSLALALEEPDLEKVVTYLAGCGLQSCPMLVAKGYPDIGWNPIEGERYLSFLRFAVFVN GESVEENANVVVKLLIRHPECFGPALRGEGGQGLLAAVLEAIKISENPALDLPTLPEGGA PVVWEEGEEEEEVAHMGNSIMSFYSALIDLLGRCAPEMHLINKGKGEALRIRAILRSLVP TKDLVGIISIPLKVPVVNKDGSVTEPDMNASFCPEHKAPMVLFLDRVYGIEDQSFLLNLL EVGFLPDLRASASLDTEVLSTTKTALALNRYIGSAVLPLLTRCAALFAHTEHYAMLVDST LHTIYRLSKGRSLTKAQRDSIEECLLAICKHLRPSMLQQLLRRLVFDVPQLTEYCKMPIK LLTNHYEQNWKYYCLPTGLGSYGIASEEELHLTKKLFWGLFDALSQKKYDAELFKMAMPC LSAIAGALPPDYVDTSPSTTLVKQVSVDAQGNFDPKPISTANISLPEKLEYIANKYAEHC HEKWSSEKFALGWTAGEKVDEKAKTHPLLKPYKALSEKERETYRYPVKESLKSMLAMGWN IERTKEGEAMFQQRETDKKTSESSQGFNPSPVDLDNVVLSRELQGMVETVAENYHNIWAK KKKMELSSKGGGTHPLLVPYDTLTAKEKYRDREKAQELFKFLQVNGYAISRGLKDMEQDS SSMEKRTAYKFLKRLLSYVDSAQEFIAHLEAMATSGKTDKSPHEQEIKFFAKVLLPLIDQ YFKNHCLYFLSSPSINLSSSGYASNKEKEMITSLFCKLASLVRHRISLFGSDSATMVSCL HILAHSLDFRTVMKSGSELVKAGVRTFFENAAEDLEKTLENLKLGKLGQSRTQMKGVAQI IAYTSVALLPILTALFQHITQHQFGVDLLLDDVQLSCYRILTSLYSLGTGKNIYVEKQLP ALGECLATLVGAMPVAFLEPHLNMHNPCSVFNTKTPRERAILSMPDTVEEMCPEMPRLDG LMKDIHDISESGARYTEMPHIIEVVLPMLCNYLSYWWAKGPENSPSDVSCCTTVTSEHLS LILGNILKILNNNLGIDEASWMKRIAVYTQPIICKAGADLLRTHFLPTLEKLKKKTVKVV AEEELLRAESRADTQEAELQILDEFAVLCRDLYAFYPMLIRYVDNNRSKWLKKPDSDSTE LFKMVSEIFILWCKSHNFKREEQNFVVQNEINNLAFLTGDSKTKMSKSGGQDQERRGKKR KRELYSVQTSLIVAAHKKLLPIGLNMCSPGDQELVSLAKIRYSLKDTDDEVKDYLKQNLH LQEKTEDPGVQWQLNLYKDVIVKSEEPPDAEHTVERIQGISAAVFHLEQVEQPLRNKKLV WQKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLMGYQKLWIVAEEYSFEEKLVQDLAK TPMVVEKEEEEAEAEVQPDPLNHLILHFSHNALTERSFLEEDPLYIAYADMMAKSCAEDE EEEEEGKEKTFEEKEMEKQKILYQQARLHARGAAEMVLQMISASKGRLGPMVTCTLKLGI SILNGGNVVVQQKMLDYLKEKRDAGFFKGLSGLMQSCSVLDLNAFERQNKAESLGMVTEE GSINVSERGSKVLQNDEFTKDLFRFLQLLCEGHNNDFQNFLRTQTGNTTTVNIIISTVDY LLRLQESISDFYWYYSGKDVIDEHGQRNFSKALAVAKQIFNSLTEYIQGPCIGNQQSLAH SRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELMDLQKDMVVMMLSLLEGNVVNGTIGK QMVDTLVESSSNVEMILKFFDMFLKLKDLTTSDNFKEYDPEGKGIISKKEFQKSMESQKQ YTQSEIEFLLSCAEADENDMFNYKEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDSRLAT FLDLAESVLSYFEPYLGRIEIMGGAKRIERVYFEISESSREQWEKPQVKESKRQFIFDVV NEGGESEKMELFVNFCEDTIFEMQLASQISEPDAVERPEEEEDEVQSLLEELAEGEDGSQ ESASAFTVACTSVKKKMSKFRQTLTFKSMRKQFKKFKKLTIREMITGFFSFFWMLFTGFF KGIFGLIFGFFHIIWSSMFGGGLVEGAKNMKVTDILGNMPDPTQFGIHGDVLEAEKTESG DLVVSMEMVQMAGPGEKLEADAIIDLISTPPKREGKHGPEPGLGDVSEIMTEASPPVEKK KSQKAAAEESEPEKADTENQEKEDKPKEEQPEEPQVEEKPAPRKRHGTTKEEAPAFMASF FAGLEVYKTKMLNYLARNFYNLRLLALFVAFAINFILLFYKVTGETDDEEEEEGPWGGDD DEDDGGMEFYVLQENTGYMAPTLTFLAVLHTIISLLCVVGYYCLKVPLVVFKREKEIARK LEFDGLYITEQPSDDDIKGQWDRLVIATPSFPNNYWDKFVKRKVINKYGDLYGAERIAEL LGLDKSALDFDPTEEAVVKEASLLSWLSSIDTKYHIWKMGVVLTDNSFLYLIWYTTMSIL GHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRK FYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYELYRILFDITFF FFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTTPHGFETHTLQ EHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14571 nt NT seq  +upstreamnt  +downstreamnt atggctgaagggggagaaggagaagacgaaattcagttcttacgaactgatgatgaagtg gtgctccagtgtgttgctaccattcagaaggagaaccgtaagttttgcctctctgcagag ggacttggaaatcgactttgctacctagagcccacttcagaagctaagtatgttcctcct gacctgtgcatctgtaactttgtgctggagcagtcgctctcagtgcgggccctgcaggag atgctggctaacacagggccaaacggggaaggaaatcctgatcatgaacgatgggcaggg caggggggcggacatcggacactgctgtacggtcacgccatcctactgaggcattccttt agtggaatgtatctggcctgtctaaagacttcaaggtctctgacagacaagctgtcgttt gatgtcggcttacaagaggattcaacaggggaagcttgttggtggaccatccacccagcc tcgaaacagagatctgaaggtgaaaaggttcgaattggtgatgatctcatcttggtcagt gtgtcttcagagaggtacctgcacctgtctatgtccaatggaaatatacaagtggatgct tctttcatgcaaacactgtggaacgtacagcctacctgctctggcagcaacgtggcagta ggatatttacggggtggacatgtgatccgtttgttccatggccatgatgagagtatgaca ataccgggatctgaccagtctgaggaacagcagaggctggtgaactatgaggctggaaaa ggagggtccaaggccaggtctctgtggaggttggagccacttcggatcagctggagtgga agtcatatgcgatggggtcagcccttccgtctgcgtcatctgtccactggccactacctg ggccagacagaggaccgtggcctggtgctggtggacagagagaagtctgataccacttcc acctctttctgctttaggccaagcaaggaaaaagtggactctggtccaaagcgggatatt gacggcatgggggtggcagagatcaagtatggtgattctgtttgcttcattatgcacgtg gccacgggactctggctatcctaccaggcgccggacgcaaaatcttcccgcttgggtctg ctcaagagaagggccttcctctatccagagggccacatggatgacgggttaattctgcag ctctgtcagcatgaggagtctagagcggcccgcatcatccgcaacaccacacagctcttc acgcagttcatcagagggctggatgcattgaagggagagaaggcctcagaggtgagcctt cctgtgggagaagtgctgcagaccctcaacgatctcattgcttacttccagcagcctgat tcagagctggatcatgaggagaagcagcggcagctccgctcactcatcaaacgccaggat cttttcaaagaggagggaatgctcactctggtctctgtttgcattgaccggctcaatgtg tacaacagtgcagctgagtttgaggaattagcaggcgaggaggctgcggaggcttggaaa gacattcttaaccttctctatgagctgcttgctgccctgatccgaggaaacagacccaac tgtactcagttctctcgcaaactggactggctggtcagcaaattggaacggctggaatcc tcttcaggcattctcgaggccctacactgtatcctgacagagagtccagaggctctgaac atcatccagaaagaccacatcaaatccatcatctctctcctctacaagcacggacgtaac cacaagattttggacattctctgctctctctgtgtctgcaatggagtggcggtcagagcc aatcagaatttcattgctgaacacctgctgcccaggagggatgtgctgctccaaacacag ttggtcaatgatgttcaaagtatgagacccaacatcttcctgggcatgagcgagggttca gcccagtataagaagtggtactatgagctgataattgaccaagtggaccactttgtgacc agctcacccacccacctgcgcgtaggctgggccaccacaaaaggctatgctccgtacccc ggaggtggagagggctggggagggaatggtgtaggggacgatctctactcctacagcttt gatggtctccatttgtggtcagggagaatcccacgggctgtggcctccattaaccagcac ttgctgaactcagatgatgtggtaagctgctgcttggacctcggcgcacccagcatgtcc ttccgcatcaacggccagcctgtgcagggaatgtttgaagacttcaacactgatggcttc ttcttccccgtcgtcagcttctcagcaggggtcaaggttcgtttcctgttgggaggtcgc catggtgactttaagttcatgcccccagccggctacgcaccttgttacgaggccctgctc ccaaaagaaaagatgcgtgtggagcctgtgaaggagtataagagagatttagagggagtg agggacttgttgggaacaactcaattcctctctcaggcctccttcatccccataccagtc aataccagccagattgttctgcctccacatcttgaaaatgtgcgtgacaaactagctgag aacatccatgaactctggggcatgaacaaaattgagcttggctggacttacggcaaggta cgagatgacaacaagagacagcacccttgcctggttgacttctccaagctgcctgaaact gaaaagaattataacctgcagatgtcaactgagactttaaagaccttattagctttggga tgtcatgttgtacacatcaatgccaatgctgaggaagatctgaagaaaataaaacttccc aaggactatatgatgtcaaatggttataaaccctcgccactagaactttctgatgtaaaa ctcacacctggtcaggaggttctggttgataaactggccgaaaacgctcacaacgtttgg gccaaagatcgcatcaagcaaggatggacctatggcattcagcaggatttgaagagcaaa cgcaatcctcggctggtgccatatgctttgttagatgaacgcacaaagaaatccaacaga gacagccttcgagaggccattcgaacactaattggatatggatataacatcgacccccct gaccaagagactgcccacgtggttgagaagttgagtgttgaaaacattcgtttcttccgt gtggagaagacctacgcagtaaagtctgggaagtggtattttgagtttgaggctgtgact ggaggagaaatgtgcgtggggtgggcccggcctggctgtagaccagacattgacctggga atggatgaccaggccttcgtttttgatggctaccgaggtcgcagggtacacatgggcagt cacttcttcggaagaacatggaacaagggtgatgtggtggggtgcatgatcaacatggag gacaaatctatgatcttcaccctcaacggagagattctcatcactaacaagggctctgag ctctgctttgctgactttgagaccgaagacgggttcatcccagtctgcagcctgggcctc tcccagattggccatatgaatctgggtaaagatgccaacacctttaagtattacactatg tgtggcctgcaggaaggctttgagccttttgctgtgaatatgaaccgagaggtccccatg tggttcagcaaacgccttcccacatttgtcaatgtgccggaagaccatgagcacattgag gtgactagaattgacgggaccgtggacaccccaccatgtctgaaagtgacccacaagacc tttgggacacaggctagcaacactgacatgatctattgccgattaagcatgccagttgag ttttatccgggtcccaggaaagtcacaaacatcaacgaagtgatcgctgatgaccaaaaa gccaagaaagacgacagtggaaagatagattataaaagcattacaaagtacttctactcg gtgagagtgtttgcaggtcaggatcctgcatcagtttggattggctgggtaaccccagat tatcactactacagcaagaacttcagcttgagcaaggtccgcacagtgacggtaactctt ggggatgagaggggccgtgttcacgaaagtgtgaggaggagtaattgctacatggtgtgt gctggagaaatttccagcagctctacaggacgcaataatattgatctggaaatcggctgt cacattgacctggactctggcctggtctcattcactgccaatgggaaggagttgcccact gcatatcaggttgagcccaacacaaaactcttccctgctgtgtttgttgagcccacaagc cccaacctgttccagtttgaatttccaaagatccaggatgccatgcccttgtcttcagca attttcaagagcttacacagtaaccccgagcctcagtgtcctccacggctggatgtgcag actattgtggctgttctgtggagcaggatgccaaacaccttcctctcagtggagacagcc cgtgtcagtgagaggcatggctgggtagtgcagtgtctcgaacctctgcagatgatggct gtgcacattcctgaggaaaacaggtgcttagatatcatggagctctccgagcacgaggac ttgagacagttccactaccatactctgaagctctactgcgctctgtgtgctttgggaaac actcgagtagcccatgccctctgcagtcatcttgaccaatcccagctcctctacactatt gataaccaatacctatctggccagctgcgcgagggcttttatgatgtcctcattagcatc cacctggagacagctaaagaagctcacctcatgatgaacaatgagttcatcatcccagtc acagatgaaacgcgaagcatccgcctcttccctgacaactccaagcgtcactctttacct ggcgtgggcctgagcacgagtctcgcacctcgcctcaacttttcccctccatgtttcatg atcaccaagcgagagtacctctacagcccccagctccccctgcgtatactgaaggagaaa gccatcagcatgctgacggaggcggtgcagggtggcggagcccacatccgagaccctgta gggggcagtgtggcgtaccagtttgtgccaattcttaaactgattggcactctgctgatc atgggagcgctaagcagtgaggaagtgaggctcatcctgcttctcatcgagcccaacgtg ttcactgagagcaaagaggaggagctgcagcttgcgttgccagaagaggcagccgagaag gaggagacgagcagcaacgaagaaaaaacagtggaggcaggagaagaagaaagtaaggaa tccaagcaggcacctaaaggccttctggaaaagagcctgccagagtcagtcaaacgtcag atgtgtgaactgctgcactatttctgtgactgtgagctgaagcagcgtattgaggccatt gtggccttctcagacagctttgtggccaagctacagtataaccagaaattccgctacaat gaactcatgcaggccctcaacatgtctgctgctgtcactgccaagaagaccaaggaattc cgctctcctcctcaagagcagattaacatgctgctgaacttcagtactggggaggactgc ccctgccccgaggaactccaagaggagcttgaagcctttcatgatgacctgcgactacac tgtggcattcccatggaggaagaagaagaggaacaggacacatctgtcaagggtcgtctg ctatccttgttatacaaaatcaaaggtcgcccacagaaaactgaggaagaaccatcagag caagaacaagcagctccaactaacctgaaggagctgatctctcagacgatggtgagttgg gctcaggagcacaccatccaggacccggagctggtgcgcagcatgttcagcctgctgagg agacagtatgatggcatcggagagctgctgcgtgccatgagaaagagctacaccatcagt gaaaagtctgtgcaggatgccatcaacctgctggcctcgctgggccagatccgctcactg cttagtgtccgaatgggagaagaggagggccagctcatgatcgacggcctgggggatatt atgaacaacaaagtgttctatcagcacccaaatctgatgcgtgttctaggcatgcatgag acagtcatggaggtcatggtcaacgtgctcggaggagacaagtctaaggagattgctttt cccaaagtggtggccagttgctgccgtttcctctgctacttctgccgcatcagccgtgag aatcagaaagctatgtttgaccacctgagctacctgctggagaacagtagtgtgggactg gcttgtccagccatgaggggctccactccactggatgtggctgcgtcctctgtgatggac aacaacagtctggccctggcattagaggagccagacctggaaaaggtggtaacatatctg gctggctgtgggctacaaagctgcccaatgctggtagccaagggataccctgacatcggc tggaatcccatagaaggagagcgctacctgtccttcctccgatttgctgtctttgtcaat ggtgagagtgtggaggagaacgctaatgtggtggtgaagctgttgatcaggcatcctgag tgctttgggccggctctaaggggagagggtgggcaaggtctgctggctgccgtgctggag gccattaaaatctctgagaatcctgcactggacctgcccactcttcctgaaggaggagca cctgtggtctgggaggagggagaggaggaggaagaggtggcccacatgggcaactccatc atgtccttctactcagccctcatcgatcttctggggcgttgtgcccctgagatgcattta atcaacaagggcaaaggtgaagccttgcgtatccgtgccatcctgcgctctctagtgcct acgaaagacttggtgggcatcatcagcatacccctcaaagtgcctgtggtcaacaaagat ggtagtgtcactgagccagatatgaatgctagtttctgtcctgagcacaaggccccaatg gtgctcttcctggaccgagtctatggcatagaggaccaaagcttccttttgaacctgctg gaggtgggctttctgcctgacctgcgtgcctccgcctctctggacacggaagtgctaagc accacaaagacagccctggccctgaacagatacattggctcagccgtgcttccgctgctg acccgttgtgctgctctctttgctcatacggagcactatgccatgctggtggattccaca ctccacaccatctaccggctttccaaaggccgctcactcaccaaggcccagagagactcc attgaagagtgcctgcttgccatctgcaagcacctgcggccctctatgctgcagcagctc ctgcgccgccttgtctttgatgtgccacagctcacagagtactgcaagatgcccataaag cttttgaccaatcactatgagcagaattggaaatattactgcctgcccactggcctggga agctatggcatagcctcagaggaggagctacatctcaccaagaaactcttctggggcctt tttgatgcactctctcagaagaaatacgacgcagagcttttcaaaatggccatgccttgt ctgagtgccatagctggagcactaccaccagactatgttgacacaagcccaagcactact ctggtgaagcaagtctctgtggatgctcagggcaactttgaccctaagcccatcagcact gccaatatctccctgcctgaaaaattggagtacattgccaacaagtatgccgagcactgc catgagaagtggtcttctgaaaagtttgcactaggctggactgcaggagagaaggtggat gaaaaagccaaaactcaccctctactgaaaccatacaaagcactgagcgagaaggagagg gagacctaccgctatcctgtgaaggagtctctgaagagcatgttggccatgggctggaac atcgagaggaccaaagagggagaggccatgttccagcagcgtgagacagacaaaaagacc tcagagtcttcccagggatttaatccatcacctgtggatttggataatgtagtcctgtcc cgagagttacagggaatggtagagactgtagcagagaattatcacaacatttgggcaaag aaaaagaaaatggagctaagtagcaaaggaggtgggactcatcctctactggtgccgtat gacactctgactgctaaggaaaagtacagagacagagagaaggctcaggagctattcaaa ttcctgcaggttaatggatacgcaataagcagaggtctgaaggatatggagcaggattct tcctctatggaaaagaggactgcctacaaattccttaagagactgcttagttatgtggac tctgcacaggaattcatagcacatctcgaggcaatggctaccagtggaaaaacagacaaa tctcctcatgaacaagaaataaaattctttgcaaaggttctcctgcccctgattgaccag tactttaagaaccactgcctctacttcttgtcctcacccagcatcaacctgagcagcagt ggctatgcttccaacaaagagaaggagatgatcaccagtctcttctgtaagctggcatct cttgtcagacataggatttctctgtttgggagtgactctgccacaatggtgagctgtctg cacatcttggcacattcattggatttcaggacagtgatgaagtctggctcagagctggtg aaggcaggagttaggacattctttgagaatgcagcagaagacctggaaaagactttggag aacctcaagctgggcaaactgggacagtcccgaacccagatgaaaggagttgcccagatc atcgcctatacctcggtggccctgttgcccattctaactgctctttttcagcacatcacc cagcaccagtttggcgtggacttgctgttggacgatgttcagctgtcctgttatcgcatc ctaaccagcctctactccttgggaactggaaagaacatctatgttgagaaacagcttcct gcactgggggagtgcttggccactctggtgggtgccatgccagtggccttcctggagcct catctgaacatgcacaatccctgctctgtcttcaacaccaaaacacctcgagagagggca attctgagtatgcctgacacggtggaggagatgtgtcctgagatgcctcgactggacggc ctgatgaaggacatccatgacatctcagagtctggggcacgctacactgagatgccccac atcattgaggtcgtcctgcccatgctgtgtaactatctttcctactggtgggcaaaaggc cctgagaactcaccgagtgatgtaagctgctgtaccacggtcacctctgagcaccttagc ctcatccttggcaacatcctcaagatcctcaacaacaaccttggcattgatgaagcctcc tggatgaagaggattgcagtgtacacccagccaatcatttgcaaggccggtgcagatctc ttgcgaacacacttccttcccacactggagaaactgaaaaagaagacggtgaaggtggtg gctgaagaggagctgctgagggctgagagcagggctgatacccaggaggccgaactacag attctggatgaatttgctgtcctctgcagggacctgtatgccttttaccccatgctcatc cgctatgtggacaacaacaggtccaaatggctaaagaagcctgattcagattcaacagag ctttttaaaatggtgtcagagattttcatcctctggtgtaaatctcacaatttcaaaaga gaagagcaaaactttgttgtgcaaaatgaaatcaacaacctagccttcctcactggagac agcaagaccaagatgtcaaagtcaggaggccaggatcaggagaggagagggaagaagaga aaaagagaattgtactctgtccagacatccctaatcgtagcagctcataagaagttgctg cccattggcctcaacatgtgctcccctggagatcaggagctcgtctctctggccaagatc cgttacagtctgaaagacactgatgatgaggtgaaggattacctgaagcagaacctccat cttcaggagaagacagaggacccaggagtgcagtggcagctgaacctctataaggatgtg atagtgaagagcgaggaacctccagatgctgaacacactgtggagagaatacagggcatc tcggctgcggtcttccatctggagcaggtggaacagcctctgaggaacaagaagctggtg tggcagaagctgctgtctaaacaacgcaagcgtgctgtggttgcttgcttccgcatggca ccactgtataatctaccaaggcatcgctctattaatctcttcctcatgggctatcagaaa ctttggatagtagcagaggagtactcctttgaggagaagctagtgcaggacctggcaaaa acccctatggttgtggaaaaggaagaggaggaagcagaagctgaggttcagccagatcct ctcaaccacctcatcctccacttcagtcataatgccctcactgagagaagtttcctggaa gaagatcccttgtatattgcttatgcagatatgatggcaaagagctgtgccgaagatgaa gaggaggaggaagagggaaaagaaaaaacatttgaggaaaaagagatggagaagcagaaa attctgtaccagcaggccaggctgcatgcacgtggagctgctgagatggtgctccagatg atcagtgccagcaaagggcgacttggccccatggtgacttgcactctaaaactgggcatc tctattcttaatggaggcaatgtggttgttcagcagaaaatgctggactacctaaaagag aaaagagatgcaggttttttcaaaggtttatctggactcatgcagtcttgcagtgtactg gacttgaatgcatttgagagacaaaataaggcagagagccttggaatggtgactgaagaa gggtcaatcaacgtgagtgagcggggttccaaagtactacaaaatgatgagtttacgaag gatttatttcggtttttgcagcttctctgtgagggccacaacaatgatttccagaacttt ctgcgaactcagacaggaaacacaactacagtgaatatcattattagcacagtggactac ctgctacgtctacaggagtccataagtgatttctactggtattactctggaaaagatgtc attgatgagcatggacaacgtaacttctccaaagccctggcagtagctaaacagatattc aactcactcactgagtacattcagggcccttgcattgggaatcagcagagtctggctcac agcaggttgtgggatgccgtggttggattccttcatgtctttgccaacatgcaaatgaaa ttatcacaggactctagccagattgagctgctaaaggaactgatggatttgcagaaagat atggtggtcatgatgttatctcttctggagggtaatgtggtgaatggcacaatcggtaag cagatggtcgacaccctagttgagtcctcaagcaacgtggaaatgatcctcaagttcttt gacatgttcctgaagttgaaggatcttactacctctgacaactttaaagagtatgaccca gaaggaaaaggaattatttctaagaaagagttccagaagtcaatggagagccaaaagcaa tacacacagtctgagatcgagtttcttctctcttgtgctgaggccgatgaaaacgacatg ttcaactacaaggagtttgtggaacgcttccatgagccagccaaggacattggcttcaat gtggctgtgctgctcaccaatctgtctgagcacatgcctcacgattcacgtctagccacc ttcttggacctggctgagagcgtgctcagttactttgagccctacttgggccgtatcgag atcatgggtggcgccaagcggattgagcgagtctactttgagatcagtgagtccagcagg gagcagtgggagaagcctcaggtaaaagagtccaagcgacaatttatctttgatgtggtc aacgagggaggcgagagcgagaagatggagctgtttgtaaacttctgtgaagacacaatc tttgagatgcagctggcttcccagatatccgaaccagatgctgtggaacgacctgaggaa gaggaggacgaggtacagagtctgttggaggaactggctgagggcgaagacggctcccag gagtcagcttcagcattcactgtcgcttgcacctctgtgaagaagaaaatgtccaagttc cgtcaaacgctgaccttcaagagcatgcggaaacagttcaagaagttcaagaaattaacc atcagagaaatgatcactggcttcttttccttcttctggatgctcttcactggattcttc aaaggcattttcggcttgatcttcggatttttccatattatatggtcctcaatgtttgga ggaggccttgttgagggagctaaaaacatgaaggttacagacatcttgggcaacatgcct gatcccacacagtttggaattcatggcgatgtactggaggcagagaaaactgagagtggt gatttagtggtgtctatggaaatggtacaaatggctggtcctggggagaagttagaggcc gatgccatcatagatctcataagtacaccgcctaagagagagggaaagcatggacctgag ccaggactgggggatgtctcggagatcatgacagaagccagtccccctgttgagaagaag aaaagtcagaaagctgccgcagaggagtcagaaccggagaaagcagacacggaaaatcag gaaaaagaggataagcccaaagaggaacagcctgaggagccacaagtggaggaaaaacca gcgccaagaaaacggcatggcacaacaaaggaggaagctccagcattcatggccagcttc tttgccggcttagaagtctacaagaccaagatgctgaactacttggctcgtaacttctac aacctccgtttgctggcactgttcgtggcattcgcaatcaacttcatcctgctcttctac aaggtgactggtgaaactgatgatgaggaggaggaggagggtccgtggggcggtgatgat gatgaggatgatggtggtatggaattctatgtacttcaggagaacactggctatatggca cccactctgactttcttggccgtactgcacaccatcatttccctcctgtgcgtggtgggg tattactgcctgaaggttcctttggtggtatttaagcgggagaaggagattgccaggaaa cttgagtttgatggcttgtacatcactgaacagccctccgatgatgacatcaaaggacag tgggatcgtttggttattgctactccgtcattccccaacaattactgggacaaatttgtc aagaggaaggtcatcaacaaatatggggatttgtatggagcagagcgcattgctgaactc ctcggtctggataagagcgcactcgactttgatcccactgaggaagctgtggtgaaggag gcctctttgttgtcgtggttgagctctattgacacaaagtaccacatctggaaaatggga gttgtccttactgacaattctttcctttatctgatctggtacaccaccatgtcaattctg ggacattacaacaacttcttctttgctgctcacttgctggatattgccatgggcttcaag accctgaggaccatcctgtcctctgtaacacacaatggcaagcagctggtgttgactgtg ggcctgctggctgttgtggtctacctgtacactgtggtggccttcaacttcttccgcaag ttctacaacaaaagcgaggatgaggatgagcctgacatgaagtgtgacgatatgatgact tgctacctattccacatgtatgtgggtgtgagagccggtggtggtattggtgacgagatt gaggatccagctggagacccttacgagctttaccgcatcctctttgacattacgttcttc ttcttcgtcattgtcatcctgctggccatcattcagggtttgatcattgatgcctttggt gagttgagagatcagcaggagcaagtaaaggaggacatggagacaaaatgctttatctgc ggaatcgggaatgactactttgacaccacaccacatggctttgagactcacaccttacaa gagcacaacctggccaactacctattcttcctgatgtatctcattaacaaagatgagact gaacacacgggtcaggagtcttatgtgtggaagatgtatcaggagaggtgctgggacttc ttccctgctggagactgcttccgcaagcaatatgaggaccagttgggctaa

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