KEGG   PATHWAY: cne03015Help
Entry
cne03015                    Pathway                                

Name
mRNA surveillance pathway - Cryptococcus neoformans var. neoformans JEC21
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
BRITE hierarchy
Pathway map
cne03015  mRNA surveillance pathway
cne03015

Ortholog table
Module
cne_M00399  Cap binding complex [PATH:cne03015]
Other DBs
BSID: 193243
GO: 0071028
Organism
Cryptococcus neoformans var. neoformans JEC21 [GN:cne]
Gene
CNB00500  hypothetical protein [KO:K12882]
CNL04290  20 kda nuclear cap binding protein (ncbp), putative [KO:K12883]
CNG03015  hypothetical protein [KO:K14328]
CNC05100  RNA binding protein, putative [KO:K12876]
CND01220  conserved hypothetical protein [KO:K12877]
CNC06360  conserved hypothetical protein [KO:K13025] [EC:3.6.4.13]
CNJ01110  expressed protein [KO:K14324]
CNC06030  RNA binding protein, putative [KO:K14325]
CNG03240  conserved hypothetical protein [KO:K12881]
CNI03520  conserved hypothetical protein [KO:K14284]
CNC00650  expressed protein [KO:K14285]
CNA07200  ATP dependent RNA helicase, putative [KO:K12812] [EC:3.6.4.13]
CNA05620  expressed protein [KO:K14294]
CNB00060  conserved hypothetical protein [KO:K13171]
CNC01440  mRNA (guanine-N7-)-methyltransferase, putative [KO:K00565] [EC:2.1.1.56]
CNB04570  poly(A) binding protein, putative [KO:K14396]
CNG01010  hypothetical protein [KO:K14397]
CNA05330  polynucleotide adenylyltransferase, putative [KO:K14376] [EC:2.7.7.19]
CNE04260  conserved hypothetical protein [KO:K14399] [EC:2.7.1.78]
CNA01730  cleavage/polyadenylation specificity factor, putative [KO:K14400]
CNF00780  cleavage and polyadenylation specific protein, putative [KO:K14401]
CND02250  cleavage and polyadenylation specificity factor subunit, putative [KO:K14402]
CNH02710  hypothetical protein [KO:K14403] [EC:3.1.27.-]
CNB01070  no arches protein, putative [KO:K14404]
CNC06560  conserved hypothetical protein [KO:K14404]
CND03400  mRNA polyadenylation-related protein, putative [KO:K15541]
CNC01430  conserved hypothetical protein [KO:K15542]
CNC00180  histone lysine N-methyltransferase, putative [KO:K14962]
CNB02030  protein phosphatase type 1, putative [KO:K06269] [EC:3.1.3.16]
CNB01720  protein serine/threonine phosphatase, putative [KO:K06269] [EC:3.1.3.16]
CND01850  phosphoprotein phosphatase, putative [KO:K15544] [EC:3.1.3.16]
CNI00130  polyadenylation factor 64 kDa subunit, putative [KO:K14407]
CNB02560  cleavage stimulation factor, 77kDa subunit, putative [KO:K14408]
CNF01910  cleavage/polyadenylation specificity factor, putative [KO:K06100]
CNN01940  conserved hypothetical protein [KO:K14411]
CNI01160  polyadenylate-binding protein, putative [KO:K13126]
CNC05580  translation release factor, putative [KO:K03265]
CNF01540  translation release factor, putative [KO:K03267]
CNC02960  ATP dependent helicase, putative [KO:K14326] [EC:3.6.4.-]
CNF01510  conserved hypothetical protein [KO:K14327]
CNE03610  protein phosphatase type 2A, putative [KO:K04382] [EC:3.1.3.16]
CNM02110  hypothetical protein [KO:K03456]
CNF03200  protein phosphatase 2A regulatory B subunit, putative [KO:K04354]
CNH02750  protein phosphatase PP2A0 B subunit gamma isoform, putative [KO:K11584]
CNB04740  conserved hypothetical protein [KO:K14416]
CNA00930  pelota, putative [KO:K06965]
Reference
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
KO pathway
ko03015   
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