Cololabis saira (Pacific saury): 133464370 Help Entry 133464370         CDS       T09849                                  Symbol ryr3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism csai  Cololabis saira (Pacific saury) Pathway csai04020   Calcium signaling pathway csai04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:csai00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     133464370 (ryr3)    04020 Calcium signaling pathway     133464370 (ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:csai04040]     133464370 (ryr3) Ion channels [BR:csai04040]  Voltage-gated cation channels   Ryanodine receptor    133464370 (ryr3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  133464370 NCBI-ProteinID:  XP_061602251 LinkDB All DBs Position 18:complement(10186267..10332938) Genome browser AA seq 4852 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQSVATIQKEHRKFCLAAEGLGNRLCYLEPTSEAKYVPP DLCICNFVLEQSLSVRALQEMLANTGQSGEGSADHEKWAGQGGGHRTLLYGHAILLRHSF SGMFLTCLKTSRSLTDKLSFDVGLQEDSIGEACWWTIHPASKQRSEGEKVRIGDDLILVS VSTERYLHLSISNGNIQVDASFMQTLWNVQPTCSSGNVAVGFLTGGNVLRLCHGHDESLT IPGADKGEEEQRIVNYEAGKGASRARSLWRLEPLRISWSGSHIRWGQAFRLRHLSTGHYL ALTEDRGLVLQDQNKSDTKATAFCFRVSKEKVDSGLKRDIEGMGAPEIKYGDSVCFVMHL ATGLWLSYLAPDAKSSRLGPLKRRACLHSEGHMDDGLTLQLCQHEEARAARIIRNTTFLF TNFIKALDSAAAGEPMAVAGYVEEVLQTLNDLIEYFKQPDSELEHEEKQCLLRSLIKRQD LFKEEGMLSLLSKCIDRMNVYNSAAHFGEMAGEEAGAAWKDILNLLYELLAALIRGNRTN CTQFSRNLDWLVSKLERMESSSGILEVLHCILIESPEALHIIQRGHIKSIISLLYKHGRN HKILDVLCSLCVCNGMAVRANQNLICDNLLPKRDLLLQTRLVNDVQSMRPNIFLGVADGS AQYKKWYYELVVDQVDHFVTGESTHLRVGWANTKGYAPYPGGGEGWGGNGAGDDLYSYSF DGLHLWSGRILRAVASINQHLLNSDDVVSCCLDLGAPSMSFRINGQPVQGMFEDFNTEGF FFPVVSFSAGVKVRFLLGGRHGDFKFLPPAGYSPCYEALLPKEKMHVEPVKEYKRDHDGV RDLLGTTKFLSQASFIPTPVDTCQIVLPPHLDNIRDKLAENIHELWGMNKIELGWTYGKV RDDNKRQHPCLVDFTKLPETERNYNLQMSSETLKTLLALGCHVAQVNVHAEDDLKKIKLP KDYMMSNGYKPAPLDLSDVKLNAGQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKSR RNPRLVPYALLDERTKKSNRDSLREAIRTMVGYGYDIDPPDQEVVHVTDDQNIETIRFFR VEQTYAVKTGKWYFEFEVLSGGDMRVGWARPGCRPDVELGTDDQAFVFDGYRGRRMHAGS RYFGHPWKKGDVVGCMINMEDKSMIFTLNGELLITSKGSELGFADFETEDGFIPVCSLGM SQIGQMNLGKDASTFKYYTMCGLQEGFEPFAVNMNRDITMWFSKRLPTFFNVPKDHMYIE VTRIDGTIDSPPCLKVTHKTFGTQNSNSDMVYCRLSMPVEFYSADGLLDESLKLSCPPKE DGSVDYESITSYYHSVRVFAGQDPARVWVGWVTPDYHYYSKNFGLSKTRTVTVTLGDERG RVHESVQRGNCYMVCAADALGPSSSSRSNSDLEIGCLVDLATGLVAFTANGKDLPTVYQV EPNTKLFPAVFAAPTSANLFQFEFVKIKDAMPLSSAIFQSEQRNPVPQCPPRLDVQTIVA VLWSRMPNTFLSVEVARVSERHGWVVQCLEPLQIMAVHIPEENRCLDILELSEHEDLRKF HHHTLKLYCALCALGNTRVSHALCSHLDQSQLLYTIDNQYLSGMLREGFYDVLISIHLET AKEGRLMMNNEFIIPVTEETRTIKLFPDESKQHSLPGVGLSTSLKTRVNFSPVSIINTKR HQYLHSPQIPLGILKEKAISMLTEAVQGGGSHIRDPVGGSLEYQFVPILKLIATLLIMGV LTSEEVRLILLLIDPNVFGESQEGEEAKGDEVAVAAEKEEVSRNEEKAVEAGEEETKESK PPSKGLLEKSLPESVKRQMCELLHYFCDCELRHRIESIVSFSDNFVSKLQYNQKFRYNEL MLALNMSAAVTAKKTKEFRSPPQEQINILLNFSAGEDCPCPEEIQEKLNSFHDELRLHCG IPVEESEEEQDTSIKGRLLALLYKIKGPPQKTEEEPTEKEQAAPTNLKELISQTITSWAQ ESYIQDPELVRVMFSLLRRQYDGIGELLRAMKKSYTISAASVQDAINLLASLGQIRSLLA VRMGKEEEKLMIDGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKSQKIAFPK MVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASEAMRGSTPLDVAASSVMDNN GLALALEEPDLEKVVTYLAGCGLQSCAMLVAKGYPDIGWNPIEGERYLSFLRFVVFCNGE SVEENANVVVKLLIRRPECFGPALRGEGGQGLLTGMKEAIKISDDPALDLPKIPTGDAAG SGEEEEEVIHMGNAIMSFYSALIDLLGRCAPEMHLINAGKGEALRIRAILRSLVPTSDLV GIISIPLKMPVINKDGTVTEPDMSACFCPDHKAPMVLFLERVYGIQDQSFLLQLLEVGFL PDLRASASLDTEVLSTTETALAMNRYIGSALLPLLTRCADLFANTEHYTHLVDSTLETIY RLSKARSLTKAQRDAIEECLLTICKHLRPSMMQQLLRRLVFDVPMLTEYCIIPLKLMTNH YEQNWKYYCLPSGFGSFGITSEEELLLTKKLFWGILDSLSHKKYDPELFKMAMLCLCAIA GALPPDFVDTSLGATLEKQGSVDAQGNFEPKPVNTANISLPEKLEYIANKYAEHSHDKWS SDKMSAGWKHGDNVDEQSKTHPLLKPYKSLSEKERETYRWPVKESLKSMLAMGWNMERTK EGEALFQQRESEKQRKMSETQMNGFSPAPVDLHSVTLSRELQGMVEVVAENYHNIWAKKK KSELLSKGGGAHPLLVPYDTLTAKEKYRDREKAQELFKFLQMSGYVITRGLQDMEPDSSS MEKRFSYKFLKRMLHYIDSAQEFIAHLEAMATSGKTDKSPHDQEIKFFAKVVLPLIDQTF KNHCLYFLSTPSRNWSSCGCASNKEKEMVTSLFCKLAALVRHRISLFGSDSAMMVSCLDI LSHSLDTRTVMKSGAELVKAGVRTFFENAAEDLEKLVEMLKLGKFLQSRAQMKSVSQSIT YVTVALLPILTALFEHIKTYEFGVDLLLNDVQLSCYRILMCFFTLGTGKNMFVERHLPAL GECLATLVGAMPVAFLEPQLNAYNPLSVFNTKTPRERAILSMPDTVEEMCPEMPRLDKLL KDINDISESGARYSDIPQVIEVILPMLCNYLSYWWEQGVENCSQDTDCCTMVTSDHLSSI LGNILKILNNNLGIDDAPWMKRIAVYSQPIICKAGADLLRKHFLPTIDKLKKKTIKVVAE EELLKADSKGDNQEAELLILDEFAMLCRDLYAFYPILIRYVDNNRSRWLKEPDADSTELF KMVAEIFIMWCKSHNFKREEQNFVIQNEINNLGFLTGEGKAKMSKAGGDQERKHKRRRGE LYSIQTSLIVAALKKLLPIGLNMCTAGHQELVSLAKIRYSLKDTDDEVKEHLRQNLHLQE KSDDPAVQWQVNLYKDIVVKSEDLTNPEHTVQRIQSISAAIFHLEQVEQPLRNKKCVWQK LLSKQRKRAVVACFRMAPLYNLPRHRAINLFIPAYERLWIEAEEYSFEEKLVQDLAKTPM KIVDEEEEEVAEVKPDPLHQLILHFSHNALTERSHLEEDPLYIAYADMMAKSCAEDEDEE EEEEGKEKTFEEKEMEKQKILYQQARLHARGAAEMVLQMISASKGHLGPMVTCTLKLGIS ILNGGNVHVQQKMLDYLKEKKDAGFFKSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEG SIHTQRGSKVLQNDEFTRDLFRFLQLLCEGHNGDFQNFLRTQTGNTTTVNIIISTVDYLL RLQESISDFYWYYSGKDVIDETGKRNFSKALSVAKQIFNSLTEYIQGPCIGNQQSLAHSR LWDAVVGFLHVFANMQMKLSQDASQIELLKELMDLQKDMVVMLLSLLEGNVVNGTIGKQM VDTLVESSSNVEMILKFFDMFLKLKDLTTSDNFREYDPECKGVISKKDFQKSMESQKQYS QSEIEFLLSCVEADENDMFNYKEFVERFHEPAKDIGFNMAVLLTNLAEHMPHDCRLGTFL AVAESLLGYFEPYLGRIEIMGSAKRIERVYFEISESSREQWEKPQVKESKRQFIFDVVNE GGESEKMEMFVNFCEDTIFEMQLASQISEPDVVEQPEDEEEEEHSILDELAAEEEAALES ASAFTTACRSVKKNLSDVRHFFTFKSIRKQFKKVKKLSIREIITGFFSFFWMLFTGFFKG IYGLIFGFFHIIWSSMFGGGLVEGAKNIKVTDILGNMPDPTQFGIHGDAVEGDKVETVES SGSIDVAMAPAGDIGEVDAMLDMLTGPKKEGGKHVELGLGDVSEHSASSSSSVNKKVSSL ADTLESQPEKADTEKKEKEDKPKEEEAAKEPVPEEKPKPRSSQPKDESPAFMSIIFAVLD VYLNKILNYLARNFYNLRFLALFECFAINFILLFYKVTGENDDEIPEEHRWGGDDDVDTF FDMDEFVLQESSGYMLPTLRFLAIFHTVISLLCLVGYYCLKVPLVVFKREKEIARELEFD GLYITEQPSDDDIKGQWDRLVINTPSFPSNYWDKFIKRKVINKYGDMYGAERIAELLGLD KNALDFDPTVETVENEASLVSWFSSIDTKYHIWKLGVVLTDNYFLYLIWYTTMSIFGHFN NFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNK SEDEDEPDMKCDDMMTCYMFHMYVGVRAGGGIGDELEDPAGDPYELYRILFDITFFFFVI VILLAIIQGLIIDAFGELRDQQEQVKSDMETKCFICGIGNDYFDRTPHGFETHTLQEHNL ANYLFFLMYLINKDETEHTGQESFVWKLYQERCWDFFPTGDCFRKQYEDQLG NT seq 14559 nt NT seq  +upstreamnt  +downstreamnt atggccgagggcggagagggagaagatgagatccagttcttgagaactgacgatgaggtg gtgctccagagcgtggccaccatccagaaggagcatcgcaagttctgtctggcagcagag ggactcggaaaccgtctgtgttacctggaacccacttctgaagctaagtatgttcctcca gacctgtgtatttgtaactttgtgctggagcagtccctgtcagtccgggccctgcaggag atgctggctaacaccgggcagagcggcgaagggagtgctgaccatgaaaaatgggcgggt caggggggtggccatcggaccctgctctacggtcatgccattctcctacgccactccttc agtgggatgttcttgacttgtttgaagacgtcaagatctctcacagacaagctctcgttc gatgtcggactgcaagaagattcaataggagaagcctgctggtggacgatccatcctgcg tccaagcagagatcggagggagagaaagtccgcattggcgacgatctgattctcgtcagc gtgtcaacggagagatacctgcatctctccatctccaacggcaacattcaggtggatgca tcattcatgcagaccctgtggaacgtccagccgacctgctcctcgggcaacgtggctgtc gggtttttgactggtggaaatgtgttgcgcctctgtcacggccacgacgagagcttgacc atccctggagcagacaagggtgaagaggagcaaagaatagtgaactatgaggcgggaaaa ggagcatccagggctcgctctctgtggagacttgagcctctcaggatcagctggagcggc agccatatccgatggggccaggctttccgactacgccatctctccactggccattacctg gccctgacggaagaccgaggtctggtcctgcaggaccaaaacaagtctgacaccaaggcc actgcgttctgcttcagggtctctaaggaaaaggttgactctggcttaaagagggacatc gagggcatgggagcgccggagatcaagtacggagactccgtctgcttcgtcatgcatctg gcaacaggactctggctgtcatacttggcgcctgatgccaaatcgtctcgtctgggtccc ctgaaaagaagggcctgcctccactctgagggccacatggatgacggcctcaccctccag ctgtgccagcacgaggaagctcgcgctgcacgcatcatccgaaacaccacattcctcttc accaacttcatcaaggctctggacagcgctgcggcaggtgagcctatggcagtagctgga tacgttgaagaggtgctgcagacgttgaacgatctgatcgagtacttcaagcagcctgat tccgaactggagcacgaggaaaaacaatgtctgctccgttcactcatcaaacgtcaggac ctcttcaaggaggagggtatgttgagtctgctgtccaaatgcattgaccggatgaacgtg tacaacagtgcagcccactttggagagatggccggggaggaggcgggcgcagcttggaaa gatatcctcaacctcctctatgaactcttggctgcactgattcgcggaaacaggaccaac tgtacccagttttcccggaacttggactggttggtcagcaaactggagaggatggagtct tcatcaggaatcctggaagtccttcactgtatcttgattgagagcccagaggcgctgcac atcatccagagagggcacattaaatccatcatctctctgctctacaagcacggacgcaac cacaagatcctggatgtcctgtgctctctttgtgtttgcaacggcatggcggtgagggcc aatcaaaacctcatctgcgacaacctgcttcccaaaagagaccttttgcttcagacacga ctcgtcaatgacgttcagagcatgaggcccaacatcttcctgggcgtggctgatggttcg gcccagtataagaagtggtactacgagctggttgtggaccaggtggaccactttgtcact ggagagtcgacccacttgagggtgggctgggccaacaccaaaggctacgccccgtatccc ggtggaggagaagggtggggaggcaatggcgctggggatgacctgtactcgtacagcttt gatggacttcatctctggtcaggtcgcatcctgcgggccgtggcctccatcaaccagcac ctgctgaactctgatgacgtggtcagctgttgtctggacctgggtgctcccagcatgtcc ttcaggatcaacgggcaacccgtccagggcatgtttgaggacttcaacactgaaggattc ttcttccccgtcgtcagcttctctgcaggtgtcaaagtccgattcctgttgggtggacgt cacggagatttcaagttcttgccacccgccggttactctccgtgctacgaagcgctgctg cccaaggagaagatgcacgtggagcctgtgaaggagtacaagagggaccacgacggcgtc cgtgacctgctgggaaccaccaagttcctctctcaggcctccttcattcccacacctgtt gacacctgccagattgtccttcccccccatctggacaacatccgtgacaagctggcagaa aacatccatgaactttgggggatgaacaagatcgaactgggctggacttacggcaaggtt cgtgatgacaacaagcggcagcacccttgccttgtggatttcaccaagctgcctgaaacc gaaaggaactacaacctgcagatgtccagcgaaacgcttaagaccctattggcactggga tgccatgttgcccaggttaacgttcatgccgaagatgatctaaagaaaatcaaattacca aaagactacatgatgtctaatggatacaagcctgcgccactagacctctctgatgtaaaa ctgaatgcaggtcaagaggttctagttgataaattggctgaaaatgcacataatgtgtgg gccaaagacagaataaaacaaggatggacctatggcatccagcaggatttgaagagcaga cgtaaccctcgtctggtgccatatgctttactggatgaacgcacaaagaaatctaacaga gacagtctccgagaggccatcaggactatggttggatatggatatgacattgatccccca gatcaagaagtcgtgcatgtgacggatgatcagaatatcgagaccatccgcttcttccgt gtggagcagacgtacgctgtgaagacggggaagtggtactttgagtttgaggtcctgagc ggaggcgatatgagggttggctgggcccgaccaggctgcaggcccgatgtggagctggga acggatgaccaagcctttgtctttgacggatacaggggccggcggatgcacgcaggcagc cgctactttggacatccatggaagaagggcgacgttgttggttgcatgatcaacatggag gacaaatctatgattttcaccctgaatggagagctcctgattacaagcaagggctctgaa cttggctttgctgactttgagacagaggacggtttcatcccagtttgcagtctcggcatg tctcagatcggccagatgaatctggggaaagacgccagcacgtttaagtactacaccatg tgtggtctgcaggagggctttgagccgttcgccgtcaacatgaacagagatatcaccatg tggttcagcaagcgcctgcccacctttttcaatgtgcccaaggaccacatgtacattgag gtgacaagaattgacggaacaatagacagccctccgtgtctgaaagtcacccataagaca tttggcacccagaacagcaacagcgacatggtgtactgcagactgagcatgcctgtggag ttctactctgcagatggactgctggacgaatcactgaaactcagttgccctccaaaggaa gatggaagtgttgactatgaaagcatcacaagctactaccactctgtgagggtgttcgca ggacaggaccctgccagggtgtgggtgggctgggtcacacctgactatcattactacagc aagaacttcggtctcagcaaaacccgaaccgtcaccgtaaccctgggagacgagcggggc cgcgtccatgagagtgttcagaggggtaactgctacatggtgtgtgcagcagacgctctc gggccgtcttcctccagccggtccaactctgacctggagatcggctgtctggtcgacctg gcgactggtctggtcgccttcactgccaacggcaaggacctacccaccgtataccaggtg gagccaaataccaaactcttcccagcagtgtttgcagcccccaccagcgcaaacctcttc cagtttgaatttgtcaagatcaaggacgccatgccgctgtcgtcggccatattccaaagt gagcagaggaacccagtgccgcagtgcccgccgcggctggacgtgcagaccatcgtggct gtgctttggagccggatgcccaacaccttcctcagcgtggaggtggctcgcgtcagtgaa aggcacggctgggtggtccagtgtctagagccgctgcagattatggctgtgcacatacca gaggagaacagatgtctggacatcctggagctatcggagcacgaggacctgaggaagttc caccaccacactctaaagctgtactgcgccctctgtgctctcggaaacacccgtgtcagt catgcgctctgcagccacttggaccagtcgcagcttctctacaccatcgataaccagtac ctgtctggtatgctgagagaaggcttctatgacgtcctcatcagcatccaccttgagacg gcgaaagagggccgcttaatgatgaacaacgagttcattatccccgtaacagaggagacg cgcaccatcaagctgttcccggatgagtccaagcagcattcgttgcctggcgtgggcttg agcacctccctgaaaactcgagtcaacttctcacccgtcagcatcatcaacaccaaacgt caccagtacctccacagcccccagatcccgctaggcatcctgaaagagaaggccatcagc atgctcaccgaggctgtgcagggcggaggctcccacatccgagacccagtcggggggagt ttggagtatcagttcgttcccatcctcaagcttattgcaacactgctgataatgggagtc ctgacgagcgaagaggtgaggctgatcctcctcctgattgatcccaacgtgtttggggag tcccaggagggtgaggaagcgaagggcgatgaggttgccgtggcagcagagaaagaggag gtgagcagaaatgaagagaaggccgtggaggcgggagaagaggaaaccaaggaaagcaaa ccaccgtcaaaaggactgctggagaagtcgctgcctgaatctgtcaaacgccagatgtgt gagcttctgcattacttctgcgactgtgaactccggcaccgcatcgaatccatcgtttcc ttctccgacaactttgtttccaagctgcagtacaaccagaagttccgctacaacgagctg atgctggctctcaacatgtctgcggccgtcaccgccaaaaagaccaaggagttccggtca cctccgcaggagcagatcaacatcctgttgaacttcagcgcaggcgaggactgtccctgc cccgaggagatccaggagaaactcaactctttccacgacgagctacgactgcactgcgga attccagtggaggagtcggaggaagagcaggacacttcgataaaaggtcgtctcctggct ttgctctacaagatcaagggcccgcctcagaagacggaggaggagcccacggagaaggag caggctgcccctaccaacctgaaagagctgatctctcaaaccatcactagctgggctcag gagtcgtacatccaggatccggagctggtcagagtgatgttcagcctgctgaggcggcag tatgacggcatcggcgagctgctgcgggctatgaagaaatcttacaccatcagtgctgcg tctgtgcaggatgctattaacctgttggcctctctgggtcaaatcaggtctctgctggca gtgcgtatgggtaaagaggaagaaaaactcatgattgatggactcggcgacatcatgaac aataaagttttctaccagcatcccaacttgatgagggttctgggtatgcacgagaccgtc atggaggtcatggtcaacgttctgggaggagacaagtctcagaagattgccttccccaag atggtggccagctgttgtcgtttcttgtgctatttctgccgtattagccgtcagaaccag aaagccatgttcgatcacctgagttacttgctggagaacagcagtgttggactagcctct gaagccatgcggggctccactccactggacgttgcagcgtcttcagtcatggacaacaac ggtctggctctggctctggaggagccagatctggagaaggtggtgacgtacctggcagga tgtggtctccagagctgcgccatgctggttgctaagggttacccagacatcggctggaac cccattgaaggagagcgatacctgtccttcctgaggttcgtcgtcttctgcaatggtgag agcgtggaggaaaatgccaacgtggtggtgaagctgctgatcagacgaccggagtgcttt ggtccggctctgagaggagagggaggacagggtctgctcaccggcatgaaagaggccatc aagatttctgatgatccagctttggacctgcccaagatcccgacaggagacgctgctggg tctggcgaggaagaggaggaagttatccacatgggcaacgccatcatgtccttctactcg gccctcattgacctgctgggacgctgcgcaccagagatgcaccttatcaatgcaggtaaa ggtgaggcgctgcgtatccgagccatcctgcgctctctggttcccacctccgacctggtg ggcatcattagcatccccctcaagatgccagtgatcaacaaagatggcacggttacggag cctgacatgtcggcttgtttctgtccggaccacaaggcccccatggtgctgttcctggaa agagtgtacggcatccaggatcagagcttcctgctgcagctgttggaggtcggcttcttg cccgacctccgagcctcagcatctctggatacagaggtgctaagcaccacggagacggct ctggctatgaacaggtacatcggctcggcactgctgcctctgctgacccgctgtgccgac ctctttgcaaacacagaacactacacacatctggtggactccacgctggagaccatctac cggctgtccaaagcccgctcgcttaccaaagcccaaagggacgccatcgaggagtgtctg ctcactatctgcaagcatctgcgtccctcgatgatgcagcagctgctcagacgactggtg ttcgacgttcccatgctcacagaatactgcataatacctctcaagctgatgaccaaccac tacgagcagaactggaagtactattgcctgccatccggtttcgggagctttggcattacc tctgaggaggagctgcttctcacgaagaaactcttctggggaatccttgactcactttct cataagaagtatgatcctgaacttttcaaaatggccatgttgtgcctctgtgccatcgcg ggagccctccctccagactttgtggataccagtttaggagcaacactggagaaacaggga tcagtggatgcacagggcaactttgaacccaaacccgttaacactgccaacatctccctg cctgaaaaacttgagtacattgccaacaagtatgcagagcattcccatgacaagtggtcg tcagacaagatgtccgcaggctggaaacatggagacaacgtggatgagcagtccaaaacg catccgttactgaagccatacaaatctctgagcgagaaggaaagagaaacgtatcgctgg cctgtgaaagagtctctgaagagcatgttggcaatgggctggaacatggagaggaccaag gagggagaggcccttttccaacagcgagagagcgaaaagcaacgcaagatgtcggagact cagatgaatggcttcagtcctgctccagtcgacctgcacagcgtcacgctgtcaagagag ctacagggcatggttgaagtggtagcagaaaactaccacaacatctgggccaagaagaaa aaatctgaactccttagcaaaggaggaggggcccacccgctgctggttccctatgacacc ctgactgctaaagagaagtacagagacagagagaaggcccaggagctcttcaagttcctg cagatgagtggctatgtcatcaccagaggtctgcaggacatggagccggactcgtcatcc atggaaaagcgattctcctacaagttcctgaagaggatgctgcactacatcgactccgct caggagttcatcgctcatctcgaggccatggccaccagcgggaagacggataagtcacct cacgaccaggagatcaaattctttgccaaggtcgtgctgcccctgattgatcaaaccttt aaaaaccactgcctttacttcctgtccacccctagcaggaactggagcagctgcggctgc gcctccaacaaagaaaaggagatggtcaccagcctgttctgtaaactggcagctcttgtc agacacaggatctctctctttggaagtgattctgcaatgatggtgagctgtctggacatc ctcagtcactcgctggacaccaggacagtaatgaagtctggcgcggagctggtcaaagct ggtgtccggacgttctttgagaatgctgcagaggacctggagaagctggtggagatgctc aaactggggaagttcttgcagtcccgtgcgcagatgaagagcgtcagtcagagcatcacc tacgtgactgtggcgctgcttcccatcctcacggccctgtttgagcacatcaaaacctat gagtttggggtggacctgcttctgaatgatgtgcagctgtcttgctaccgaatcctgatg tgtttcttcactctgggcaccgggaagaacatgttcgtggagaggcatctgccagccctg ggagagtgtctggcaaccttggtgggagccatgcccgtagcgtttctggagcctcagctg aacgcctacaaccccctctctgtcttcaacaccaagaccccccgagaaagagccatcctg agcatgcccgacacggtggaggagatgtgtccagagatgcctcgtctggacaagctgctc aaagacatcaacgatatctcagagtccggtgctcgttacagcgacataccccaggtcatt gaagtgatccttcccatgctgtgcaactatctgtcctactggtgggaacagggtgtggag aactgctcccaagacactgactgctgcaccatggtgacctctgatcacctcagcagcatc ctgggaaacatcctaaagatcctcaacaacaacctgggcattgacgacgccccctggatg aagaggatcgcagtttactctcagccaatcatttgcaaagccggagcagatttgctgaga aaacacttcctgcccacaatcgacaagctgaagaagaagacgataaaggtcgtagctgaa gaagagctgctgaaggctgacagtaaaggtgacaaccaggaggcagaactgctcatcctg gatgagtttgctatgctgtgcagggacctctacgcgttctaccccattctcattcgttat gtggacaacaacaggtccaggtggctgaaggagccggacgcagactccacggagctcttc aagatggtggctgagatcttcatcatgtggtgcaagtcgcacaacttcaagcgtgaggag caaaactttgtgattcagaatgagatcaacaatttgggcttcctcactggagaaggcaag gcgaagatgtccaaggcaggtggggaccaggagaggaagcacaagcggcgtcgtggtgaa ttatactccatccagacgtctctgatcgtagcagccctgaagaagctgctgcccatcggt ctgaacatgtgcacggcgggacaccaagagctcgtctctttggccaagatacgctacagt ctgaaagacacagacgacgaggtgaaggagcacttgcgtcagaatctccacctacaagag aagtctgatgaccctgcagtgcagtggcaggtaaacctgtataaagacatagtggtgaaa agtgaagacctgacaaacccagaacacacggtccagagaatccagagcatctctgcagca atcttccacctggagcaggtggaacaacctctgaggaacaagaagtgtgtgtggcagaag ctgctgtccaagcagcgaaagcgtgccgtagtggcttgtttccgcatggctccattatat aatctacccaggcatcgtgctatcaacctcttcatcccggcctatgagagactttggata gaggcagaggagtactcctttgaggagaagctagttcaggacctggcaaaaacccccatg aagattgtggatgaagaggaagaggaggtggctgaggtcaagccggacccgctccaccag ctcatccttcacttcagccacaacgccctgacggagagaagtcacttggaagaagatcct ttgtatattgcatatgcagacatgatggcgaagagctgtgcagaagatgaggacgaggaa gaggaagaagaggggaaagaaaagacatttgaggagaaagagatggaaaagcagaagatt ttgtatcagcaggcgaggctgcacgctcgtggggctgctgagatggtgctgcagatgatc agcgccagcaaaggtcatctgggccccatggtgacctgcaccctcaaactgggaatctcc atcctgaacggaggcaatgtgcatgttcagcagaaaatgctggactacttgaaagagaaa aaagatgcaggctttttcaagagtctgtcaggactgatgcagtcttgcagtgtcctagac ttgaatgcatttgagagacaaaacaaggcagaaggacttggcatggtgacagaggaaggt tcaatccacactcagcggggctccaaggtgctgcagaatgatgagttcaccagagatctg ttccggtttttacaactgttgtgtgaggggcacaatggagacttccagaacttcctgaga acccaaactggaaacacgacaacagtcaacatcatcatcagcaccgtggactatctgctc cgccttcaggaatctattagtgacttctactggtactactctggcaaagacgtgattgat gaaactggaaagcgcaacttctccaaagctttatctgtcgccaagcagatattcaactca ctcactgagtacattcagggcccgtgcatcggcaaccagcagagtctggctcacagcaga ctgtgggatgcagttgtgggcttcctgcatgtgtttgcaaacatgcagatgaagctgtcg caggacgccagtcagattgagctgttgaaggagctgatggacctgcagaaggacatggtt gtcatgttgctgtctctcctcgagggtaacgtggtgaacggaaccatcggcaagcagatg gtcgacacgctggtggagtcttccagcaacgtggagatgatcctcaaattcttcgacatg ttcctcaagctgaaggatctcacaacctcggacaacttcagggagtacgaccccgagtgc aagggcgtcatatccaaaaaggacttccagaagtcgatggagagccagaagcagtacagc cagtcggagattgagttcctgctctcgtgcgtggaggccgacgagaacgacatgttcaat tacaaggagtttgtggagcgattccacgagccagccaaagatatcggcttcaacatggcg gtgctgctgaccaacctggccgagcacatgccgcacgactgccgcctcggcaccttcttg gccgtggcggagagtctgctcgggtactttgagccctacctgggtcgtatcgagatcatg ggcagcgccaagcggatcgagagggtttactttgagatcagcgagtcgagccgcgagcag tgggaaaagccacaagtcaaggagtccaagcggcagttcatcttcgacgtggtgaacgag ggaggggagagcgagaagatggagatgtttgtgaatttctgcgaggacaccatctttgag atgcagctggcctcgcagatatctgagcccgacgtggttgagcagcctgaggacgaggag gaggaagagcacagcatcctggacgagctggctgcggaggaagaagccgccctggagtcg gcctccgctttcaccacagcgtgtcgctcagtcaagaagaatctctcagacgtccggcac tttttcacttttaaaagcatacgcaagcagttcaagaaagtcaagaagctgagcatcagg gagatcatcacgggcttcttctccttcttctggatgctgttcaccggcttctttaaggga atctacggcctcatctttggtttcttccacatcatctggtcctccatgttcggcggagga ctagttgaaggagccaagaacatcaaggtgacggacattctcggaaacatgcccgacccc actcagttcggcatccacggagacgcggtggaaggagacaaagtggagactgtggagtca tcgggaagcatagacgtcgccatggcaccagcaggagacatcggagaggtggacgcaatg ttagatatgctgactgggcctaaaaaggaaggaggaaagcacgtggagctgggtctgggt gatgtttctgagcactctgcctcctcctcctcctctgtcaacaagaaagtttctagtctt gctgatacgcttgagagtcaaccagaaaaggctgacacggagaaaaaggagaaggaggat aaaccaaaggaggaggaggcagccaaggagccggtgcccgaggagaaacccaagcccaga tccagtcagcccaaagatgagtctcctgccttcatgtcgatcatctttgctgttctggat gtctacctgaacaaaattctgaactacctggctcgtaacttctacaacctccgctttctg gctctgttcgagtgcttcgccatcaacttcatcctgcttttctacaaggtaactggtgag aatgatgacgagattcccgaagagcaccgctggggcggtgacgacgacgtggacacgttc ttcgacatggacgagtttgtgctccaggagagctctggctacatgctgccaacgctgcgc ttcctggccatcttccacaccgtcatctcgctgctgtgtctggtcggctactactgcctg aaggttcctctggtggtcttcaagagggagaaggagatcgccagggagctggagtttgac ggtctgtacatcaccgagcagccgtccgacgacgacatcaaaggccagtgggaccgtctg gtcatcaacacgccgtctttcccgagcaattactgggacaagttcatcaagcgcaaggtg atcaacaaatacggggacatgtacggcgccgagcgcatcgctgagctgctgggcctggac aagaacgccctggacttcgaccccacagtggagaccgtggagaacgaagcttcgctggtc tcctggtttagctccatcgatacaaagtaccacatctggaaactgggtgtggttttgact gacaattacttcctgtatctgatctggtacaccaccatgtccatctttggacacttcaac aacttcttctttgctgctcatcttctggacatcgccatgggcttcaagaccctccgtacc atcttgtcctccgtcacccacaacggcaagcagctggtgctgacggtcggcctgctggcc gtggtcgtctacctctacacggtggtggccttcaacttcttcaggaagttctacaacaag agtgaagatgaagacgagccggacatgaagtgtgatgacatgatgacgtgttacatgttc cacatgtacgtgggcgtgagggctggaggagggattggagacgagctggaggacccggcc ggagacccctatgaactctaccgcatcctgtttgacatcaccttcttcttcttcgtcatc gtcatcctgctggccatcattcagggtctgatcatcgatgccttcggtgagctgagagac cagcaggagcaggtgaagtcagacatggagacaaaatgcttcatctgtggcattgggaac gactactttgaccggacgcctcacgggtttgaaacccacaccttacaagagcacaacctc gccaactacctgttcttcctgatgtacctgattaacaaggatgagactgaacacacgggt caggagtcattcgtgtggaagctgtaccaggagagatgctgggacttcttccctactgga gactgtttccgtaagcagtacgaggaccagctgggttag

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