Cynoglossus semilaevis (tongue sole): 103396332 Help Entry 103396332         CDS       T04866                                  Symbol obscn Name (RefSeq) obscurin   KO K17531   obscurin-RhoGEF [EC:2.7.11.1] Organism csem  Cynoglossus semilaevis (tongue sole) Pathway csem04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:csem00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     103396332 (obscn)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:csem01001]     103396332 (obscn)   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:csem04131]     103396332 (obscn) Enzymes [BR:csem01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.1  non-specific serine/threonine protein kinase      103396332 (obscn) Protein kinases [BR:csem01001]  Serine/threonine kinases: CAMK group   Trio family [OT]    103396332 (obscn) Membrane trafficking [BR:csem04131]  Others   Rho GTPase associated proteins    Rho guanine nucleotide exchange factors (GEFs)     103396332 (obscn) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  I-set Ig_3 ig Ig_2 V-set Ig_4 Ig_5 Ig_6 Izumo-Ig V-set_CD47 SOS1_NGEF_PH fn3 C1-set C2-set_2 RhoGEF FN3_DSCAM-DSCAML_C PH Adeno_E3_CR1 IQ SH3_2 DUF1722 RHG20_PH Motif Other DBs NCBI-GeneID:  103396332 NCBI-ProteinID:  XP_016897595 LinkDB All DBs Position 20:7554869..7599702 Genome browser AA seq 6304 aa AA seqDB search MDPNLFGGVPRFLTRPKAFSVCAGKDTTLSCTIVGSPTPLITWEKGKLNLTSGGRFKTVK DGDIYRLTIYDLTLEDSGQYICRAKNSVGEAYAAVTVKVALPTEMAQRAPLFTDKPTSVR VGLGGDVVFHCKVAAHPDANFDWEKDGRYLGETNRIRVVSNTDSSTLKIQSVRNLDSGTY TCRAQNSVGRAQAAAALVVDSQDSLHLASDKSTSLLSHLQKRKEEMKKDISVYRTEESSS THSSSKAIITDGLSSLSLDHELRASALAKLPKGVFTRTCTVTEGKHAKLSCFVTGHPKPH IIWRKDGINITEGRRQVIYEDHAENFILKILYCKQTDNGLYTCNATNLAGQTYSAVLVTV KEPKVPFKRKLQDVEVQEKTSATLMCEVPLTITQTNWFMEETRLEQSSKYRLEQEGTLRR LTIHNVTTNDDGVYVCEMKEGSRTVAELTVLGNITKKLPRRTVVPVSDTVIFCVELEQPI PDSYWTRNGEKLKEDSRITIACVLRQYTLTIRDCQTDDSGEVAFVAGDCKTSTRFSVTAA RKHPPDPPVDAVVQKKTDSSITIQWSPPDSDRPVPIKGYFVERRKVGTQSWQRCNAGEIL VATEITISSFIEEASYQFRICAINDFGQSPYLEVPGSFYLEPTAELSKGLMDTNAFSGEE FSISVELTAVCSGFWYLNGRLLRSGADYLITRTKTTHTLLIRVVTMEMNGTEVKFVGGGS QTSCILSVKAPCVRFTNKSERIEVVTCSTQASAQLTVEVSDYDAKQSMFVERKRILIIHN VTEEDVGIYECVLPSDKMSLQLNLKEEPVKFLNKARGAMGLSTSLKGDLELSCDVSSASA VVVWRKDQVEITEDQRTIFISKGTQRKLIIKNAKKSDEGHYSCETAEDKVTFQVKIKETQ ALAVFSNKESVQREVKATLSQKETLSCSVSDSKTEVKWFKDGKQLISSRTIYSEVKGNTR QLVIEKVERSDAGEYTCEAGGDKLVFKVSVSEAQPFFSKKVSVQTEVKATISQKAILSCE VVDAKTEVKWYKDGKLLTSTKTVHAESKGQSRQLVFESVERKDAGEYICEAGTEKLTFKI HVSEPQSYFYKKESVQKEVKATVSQKVSLSCEVADSNTEVKWYKDGKLLTHSKTIRAESK GKSRGLVIDSVEKKDAGEYICEAGTERLAFKIQVEEIQPRPVFSNKESVQKEVKATVSQK ATLSCEVADAKTEVKWYKDGKLLTSSRTVHAEAKVKSRQLVIESVEKKDAGEYVCEAGTE KLAFRIHVTEAAAVFSNKESVKKEVKATLTQKATLSCEVSDTKTEVKWYKDGKPLTSHKA IQKGKSRELVIEKIERKDAGEYTCEAGSEKLVFKLEVADAAVKFQKKPVKDTFTALASES VVLTTEVNTESASVKWYRDGAEVKEGSKYEMKTDRFSRSLIIKSTDTKDSGTYTCQTTDD KLEFKVQVKETPLKFVVPLKPADVELGGTLSLVCELNQASGDVVWNHNGREIKPGGRFCI RADGVKRLLTVSSLAKEDEGEYSCECRNDKTSAKITSKVPRAVRMTTKLNNVAAMEGKEA VFKCSVTPADANVKWFHNNVPVTAGTKYRTDHGGNTFSLTITSVTQKDAGEISVDAEGKS CKATLQVQREPVTFKKKLENLTVEEESEVKLGVELSKVSDEVRWMKNSVVLQPTANVEIR VNGAKQTLVLKSVTSADRGVYSCETLDDKTQAKLSVEKKKILVVKALKETKVHETETITL EVELSQADVEGSWTKDGAKLRPGAHCRITALEKKHALTLSNLKMDDAGMIAFQAEGVHTS AKLIVTEPPATISKPIMDISVPEKEKVTFECEVSRSNADVTWLKGDVELKPGKNLGIHSL GRKRTLVINKCSPEDAGTYICRTTDDNTSAKLTVNARDIKIIKKLQDLEVTEKESAAFVC EISHDEVDCQWFKGNAKLKVGENVKMRQEGRTYVLLFKSVAPEDMGEIKFTAEKASSTAK LKVKELPVKFVKRLRDKIAMYKHRGHLECQVSRANAQVKWYKNKVEIKPSKKYEIKSEDV YRKLTINDVDSGDEDTYTCDAIDEKTSCKLLVEEQSISIVRELNSVEVTEPFPAVFEVEI SVELVKPPAWTLNGVAVKDSVDAEMEKEGTLHRLIFKKTKASMSGPVQFTAGKSKCLAQL TVKERPLEVAEPLKDVKAKEKSAALLSCKFSAPPKEVSWFKGQFPLSPSDKYNMKQDATR AQLTIQMLTEEDTGEYHCKSGPAETKGTLTVEVREIKITKHLADTEVEEDSDAVFTCEIN YADEEAQWLLKDKVLFTNEVNTITHEGKVHKLKLKNLAPQDGGTITFQVRKVKESVTLKV KEKRAVFLKSLDDVIGEVKGMVTLACEASKPRVSPIWRKGGKTLKAGSKYELLHTGKSLG LIIKDVSKDDAGEYTCDLGTEVCKANVTVREIGIGITKWLKAAEVNEGETCSFECILSRE TTECLWTLNSKPVTDGGRFNVSSKGRKHMLTIKDVVPSDAGEVVFSIGDLNSKTTLTVEG RASSVTKGLENVTAVQGEDAIFTCCVTHSSATVKWTKDGKAIKKSQKYDISQEDKIKTLT VHNVSAQDAGEYSCEVIGGATTRAKLEIKEPIHKFVKPLKDSQADEKSSVTLQCETAQAP STVTWLKGHTELKAGGRYEMSKKDGLLTLTIKHLEEGDTDIYTCDVVTAKSMAKLTIKAL PPVFTQKLKGQEAMEGDNISMTCELSKPEIPVEWKKGSQVLRSGQKYQIKQKGSLLELII NDVTPEDSGDYSCVCGDQKTTANLKVKAQPVTFKQQLESQEAEEESSITLHCELSKPGVP VEWKKGSQVLRSGEKYQVKRNACVDELIINNAIPEDSGNYSCECGDQKTTANIKIKAKPV TFSKALKGQEADEGSRITLQCELSKPGVSVEWKKGSEVLKSGEKFQIKQKGCVVELIINN VVPEDSGEYSCVCGDQKTTANINIKAAKLESKRQETKEKAEGVQSVKTHEALSTTSSDKH MYREEKMEAVTQVTTGQTTKQQLLKQDMHRDSHEVKVREEAKTLEASSTVAADRHTYRQE ITETVEVVTQLTTGQSPTQQLLQQGFQRESLSVEAAKVESKIQESKETVEVTQLSPGLSL AQQLQRDYLEQIMGVDAATLDSKSQEMKETAGVTQLTTGQTHTHHLSEQEVQRDTQQLTF GAGAEKSASTVSSRAELEKLESVKRVEALPVKVIEHLESLEAEEESSVTLHCQLSKPGLT VEWRKGSQSLSHGEKYQMSQTGFSYELQIHDLTPGDTGTYACCFEDAASAASLAVIAAPV IFTKKLENLDANEGDSVTLSCELSKPGVSLEWRKGELGLCPCAKYGISQRGHLATLVIHD IDPEDAGSYICDAGDQQSTAKLCVNAKPVLFKNSLQNVEREAGDIAILRCETTKPGASVV WRHGDTVLESSSKYQLKQEGTSVQLIIYKLQGADSGEYSCDTGSQRTSAVLSVQEVEISI VKYLESCVVYEGEDVHFQCLISHEDAPLAQWKLEGVPLQNNEMNLIKTNGRSHSLTLRSV TAADSGTVTFSVGNHTSTASLTVKAAPVIFKKELENQEATEKGKAIFSCETSSADCKVTW RKGSSVLTNGEKYTIEQNATTHTLVIHNLSLKDSGEYSCDTGDRKTTAALTVKECIRIVR ELCDTTVITGQDAVFEVELSHSGVTDGQWWLEDNLLQNNDLNQMSSHSRVHRLVLKMVTT DETGDVAFVLGEEKSVASLLVEEKPKVVIIEKPQNTFAVEDETVTLVCTISDPKANVTWT RNNKTIQSGLKYDLKKIGAIHKLLIYDVVPADSGIYTCDTGDAQCEVTLTVKSTPVFFRK ELKNQDAIEGDDIVLSCELSKSSVSVEWRKGGMVLQPNEKFVMRKEGCVQELSINNLEPE DSGYYTCDAGDQLTTASLAVQVKEIFIVLGLKTIDVFVGESATFSCQLSGRAPGKVQWWL DGTLLKNSPLSEIGLSQGHIYTLTLKNLAPDDSGTVMFKSGNLSSTAKLLVKDPIVEVVS QMEDRLVLENQPTEFICQYSRPVKAQWKKDGQPLQPDGRRVVVEQDWNVARLYISCVSAA DRGTYTCEAEGTSVVASLHVEGKPINIVQGLENAETFVGGEALFECALSRPENKDFRWFV DGKPIKESPNFEIVTFENGRRHLLLLKDLGLQDSCTVTFKAGTATSSAQLSVKGWQLDVV KGLEDKVASVGEKVEFSVELTEPIPMAEVAWYANGVELKPSDLWAMRADGCCYHLILKRA PRLPQQEITFAARDALSLAKLTIITVPDPPEDPEVLSKTINSITLSWFTPLHDGGSPILG YKVEMRLLDSALWLPCHSETVCNTEFVVQNLTPGCSYRFRVAGINRAGSGEPVELPQTVQ LEDLTQPPFRPGTEALQLEKEALGQPSLPPEAVEEGDVHDLWEASAKKRPMSREPTLDSI TEQPEDDGKGGQKKAQQKETMSTEKAEVKSGEKEQVVMKQTESKQVTSSEDESGSGGSSF LSYLKTSSQATVSATSEAETMTAERFFAHFQMAEQRTVTSTTEVQTTTIQQTDVKQVSVE DADKVDTSKEDEPELTEAVIKIQAAFKGYKARKDMRPVFKDTFKDQTKEPSGTIHLECVV EGKPDKVRWLKDGEPLTDGKHYHIDIYNDGTCSLVITAITTKDTGVYTCEVTNKFGVTSH SGKVTVGTVRESSERRPLTVGYSADSEPESSSGSEMDESLRQASKRLRRLLRTRLPPDVE EEPFISADEGDLRPDPHSYREDDNYIYIRFDSRGDAEVASKRFQEMFTIHGVPVETTILE AGSFKVELRIKKMGYIQDGTQTPTQDRQPPAFMAGPQAAPVFLTELQSQDVPDGYPVSFD CVVIGKPPPTVRWYKDGKLLEENDHYMINEDLEGCHQLIITSVLPTDMGVYRCTAENSSG ITATKAELRVDMSCSSDYDTAADATETSSYVSAKGYMSRETETFESVAEDDQLPQVVEDL RDVHVSPGSPIAKMQLKVKGFPKPRIYWFKDGQPLRPSNRILLLTERDVHSVEILEVKKE DMGEYSAYISNAAGSAYSSARLTVLSPGEIMPQVKKDFKEPLVPPRFLERFRNRKVKQGA SITLSIKVEGSPTPQVSWLKEESIEDVLWIKPDTKGYKIASSGNKHSLILMDVGTEYTGA YTCIATNKAGQSICTAHLEVDDTQQVKKETKATDTLGITVSPPEDEASTTKEGKITYLGE VGSEEFLMKLTSQITEMVSAKITQDSLQNYEVLQWMKSWPKSTTSLRVPGADSDDETKTP SPSPHHGRSHAPSLIADSSSESDEGDARGEMFDIYVATADYNPTTPNKESISLKEGQYVE VLDSAHPLKWLVRTKPTKTTPSRQGWVSPAYLDKKLKLSADAGDLPETSAEEVSEGEYKR KLFQLIQELINGESDFVKEMNFFISHHMKQAESPDAPSDVSSQKETIFRNIDDIKSFHSR TFLSRLNDCDTDDDVAMCFLKNREGFEKYLQYLVGQSQAQSTVGDKTIHHFFKEYTEKEQ AAADPTEPPVRSIETHLQQPLERIQKYKALLKELIRNKARNGQNCCLLEEAYAMVSALPQ RSENTHHVSMIENYPATLEVLGEPIRQGPFQVWEGAPGIRSSSRGHHRHVFLFKNYCIIC KPKRDSNTDTQAYVFKNMMKLNNIDVNETVEGDDRAFEIWHEREDSVRKYTLQARTVTIK NSWLRDFRELQQRYSMPAWSPPDFDEILANCTADLGQTVKLACKVTGVPKPMVTWYKDGR PVEADPHHIIIEDPDGSCTLILDNMTADDSGQYMCFATSSAGNASTLGKITVQVPPRFVN KIRSAVFIAGEDAQFTCVIQSAPSPKIRWFKEGRLLTDQEKYQTYSELRSGVLVLVIKNL TERDLGHYECELSNRLGSAKCAADLVPPSAVARMGEQAVTIEVTEQETKIPRKTIIIEET ITTVVKNPRMRRHRSPGLTLVGAHRSETSTPETPTARVRRVPTPRKTTIPTLYVTQAEGA EARIIETKPRWVEVEEVIEYKVNKSPRLPRRRGISPAGSDRVATPSRPKRSPPENPNANN SNNKLVEKVAQAELQGDVSSQPLSWEEVAGSASFVPATSAPSELSTVLTPAGGNDDELDD QQTVVVEPDDDGDDFQMFTKQEPKLVKQGGHALTLEDLEDYVPEEGEAYGSSSIPVEKPC EVSVLQREIGGSTVGQPVLLNFGRPVVVPRHRGGFFSRFKDHLSTSPFTAAVPQASRRTR VERSVPIQVSNTKLKVKPSYCSEVQRVECGQQSFKTKVSTQTYGYTSVGKPVTLQIQDHH SQKK NT seq 18915 nt NT seq  +upstreamnt  +downstreamnt atggatccaaatctgtttggaggagtccccaggttcctcacccgcccaaaggctttctca gtgtgtgcaggcaaggataccacgctcagctgcaccattgtaggaagcccaacccctttg atcacctgggagaagggcaagctgaacctgacgtctggtggccgctttaagacagtgaag gatggagacatctaccgtttgaccatctacgacctaacactggaggacagtggccagtac atatgccgggccaaaaacagcgtcggggaggcatatgctgctgtcaccgtcaaggtggcg ctgccaacagaaatggctcagagggcccctcttttcacagataagcccacctctgtacgg gtggggctgggaggtgatgttgtcttccactgcaaggttgcagctcaccctgacgccaac ttcgactgggaaaaggatggccgctacctgggggagacgaaccgcataagggtcgtttcc aacaccgacagcagcacgttgaagatccagagtgtacggaacctggacagcggcacctac acctgcagggcacagaacagtgtgggacgcgcacaagctgcagcagctctggttgttgat tcccaagattctctgcacctggcttcagacaagagcacctctctcctctcgcatctacaa aagcgcaaggaagaaatgaagaaggacatttctgtctatcgcacagaggagagcagctcc acgcattcctcctccaaggccatcatcactgatggattgagttctctgagtctggatcac gagttgagggcgtccgctctggcaaagctacccaaaggtgttttcacccgcacctgtaca gtgactgagggcaaacatgctaagctcagctgctttgtgacaggtcaccccaaacctcac attatctggaggaaggatgggataaatatcactgaaggccgtagacaagtcatatatgag gaccatgctgagaacttcatcctcaagatcctgtactgtaagcagacggataatggtctc tacacgtgcaacgcaactaatctggctgggcagacctacagtgccgtgttggtgacagtc aaagagcctaaggttccattcaagaggaaactgcaggacgtggaggtgcaggagaagacg tcggccacactgatgtgcgaagtgcctctgaccatcactcagaccaactggttcatggag gaaaccagactggagcaaagttccaagtatcgactagagcaggaaggcaccctgcgtcgc ctaaccattcacaacgtcaccacaaacgatgacggcgtttacgtctgcgaaatgaaggaa ggcagtcgtactgtggcagagctcactgttctcggtaatatcaccaagaagctgccacga cggactgtggttcctgtcagtgatacagtcattttctgtgtggagctggaacaaccaatc cctgattcctactggactcgcaatggggaaaagctgaaggaggattcccgaataaccatt gcatgtgtcctaagacagtataccctcaccatccgagattgtcagacagacgactcagga gaggtagcatttgtggctggagactgcaagacttccactcgattcagtgtcacagctgca agaaagcatcctcctgatcccccagttgacgcagtggtgcagaagaagactgactcatcc atcacaattcagtggtctcctcctgacagcgaccgccctgtgccaattaaaggttacttt gtggaaagacggaaggttggcactcagtcatggcagcggtgcaatgcgggagaaatcctt gttgcaacagaaatcaccatctccagtttcatcgaggaagctagctaccaattccgtatt tgtgccataaacgactttggccagagtccctacctcgaggttcccggtagcttctatctt gaacccacagcagaattaagtaaaggtttgatggacacaaacgccttctctggagaggag ttctccatctccgttgagctgactgcagtttgttctggtttctggtatctaaatggacgc ctcctgcggagtggagctgactacctcatcaccaggactaagacgacacacactctgctc atccgtgtggtcaccatggaaatgaatggaactgaagtcaagtttgttggcggaggctcc caaaccagttgcatcctgtctgtaaaggcaccttgtgttaggttcaccaacaagtcagag cgcatagaagtggtgacctgcagcactcaagcctctgctcagctgactgtggaggtgtct gattacgatgcaaagcaatcgatgttcgtggagcgtaagaggatcctgattatacacaac gtcacggaggaagatgttggcatctacgagtgtgttttacccagtgataaaatgtcacta caacttaatcttaaagaggaaccagtcaagtttctgaacaaagccagaggtgccatggga ctgtcaacgtccctaaaaggagatctggagctgagctgcgatgtatcttcagcaagtgca gtagttgtctggagaaaagatcaggtggagatcactgaggaccaaagaactatcttcatc tccaaggggactcaaagaaaactcatcatcaaaaatgccaagaaaagcgatgaaggacat tactcctgcgagacagcagaagacaaagtcacattccaggtcaagataaaagaaacccaa gccctagctgtattttccaataaggagtcagtccagagggaggtgaaagccacactttct caaaaggaaactctaagctgcagtgtgtctgatagcaagacagaggtgaaatggtttaaa gatgggaaacagctgatatccagtaggaccatatactcagaagtgaaaggcaacacccgt cagctggtgattgaaaaggttgaaagaagtgatgctggagaatatacctgtgaggctgga ggtgacaagctggtttttaaggtttctgtatcagaggctcagccattcttctctaaaaag gtgtcagtccagacagaggtgaaagccaccatctcccaaaaagcgattttaagctgtgaa gtagttgatgctaagactgaggtgaaatggtacaaggatggtaagctgttgacttctacc aagacagtccacgcagagtccaagggccagagtcgtcagctggtttttgagagcgtggag agaaaagatgctggtgaatacatctgtgaggctgggacggagaagttgacctttaagatt catgtgtcagagcctcagtcgtacttctataaaaaggagtcggttcagaaggaggtgaaa gccactgtctctcagaaagtctctctgagttgcgaggtcgctgactctaatacagaagtg aaatggtacaaggatggcaagctgctgacccacagcaaaacaatccgtgcagagtcaaag ggcaagagtcgggggctggtgattgacagcgtggagaagaaagatgccggagagtacatc tgtgaagctgggactgagaggttggcctttaagatccaggtggaagagattcaacccagg ccagttttctccaacaaggagtcagtccagaaggaggtaaaagccactgtctcccagaaa gccactttaagctgtgaagtagctgatgcaaagacagaagttaaatggtacaaggatgga aaactgctgacctccagcagaacagttcacgcagaagccaaggtcaaaagtcgccaactt gtgatcgagagcgtagagaagaaggatgctggagagtatgtttgtgaggctggaacagag aagttagcctttaggattcatgtgacagaggccgccgctgtcttctctaacaaagagtcg gtcaagaaggaggtgaaagccacactgacacaaaaggctactctgagctgtgaggtttct gacactaagacagaagtgaagtggtacaaagatggaaagccgctgacctctcacaaagca attcaaaaaggcaagagtcgtgagctggtgattgaaaagatcgagagaaaagacgctgga gagtacacgtgtgaggctggatcggagaagctggtatttaagctggaagtggcagatgca gctgttaagttccagaagaagcctgtcaaagacacttttactgctctagcaagtgaaagt gttgttttgaccactgaggtcaacacagagagcgcaagtgtcaagtggtatagagatggt gcagaggtcaaggagggcagcaagtatgaaatgaaaacagacagattctctcgctccctg attataaaatccactgacactaaagacagtggcacgtacacctgtcagaccactgatgac aaactggagttcaaagtccaggttaaagagacacctctgaagtttgttgtccccttgaaa cctgctgatgtggagctgggaggaacactcagcttggtgtgtgaactgaatcaagcctca ggggatgttgtctggaaccataatggtcgtgagattaaacccggaggtaggttctgtatc agggcagatggcgtgaagcgactcctcactgtcagcagcttggccaaggaggatgaagga gaatacagctgtgaatgtcggaatgacaagacgtccgccaaaatcacatccaaagtaccc agagcagtcagaatgaccactaaactcaacaacgtggctgcgatggaaggaaaggaagcc gttttcaagtgctctgtaaccccagccgacgccaatgtaaaatggttccacaacaacgta cccgtcactgctggaaccaagtataggacagaccatggaggcaacactttctcactcacc atcacctctgtcactcagaaagatgctggagagattagtgttgatgccgaaggcaaaagc tgcaaagctacactacaagtacaacgtgagcctgttacattcaagaaaaaactggaaaac ctgacagtggaggaggagagtgaggtgaaattgggggtggagctcagcaaggtgtctgat gaagtgcggtggatgaagaacagcgttgtgctgcagcccacagccaacgtggaaatcagg gtcaatggagctaaacagactctggtgttaaagagtgtgacgtctgctgaccgtggagtc tactcctgtgagactctggatgacaagactcaggccaaactcagcgtggagaaaaagaag atccttgtagttaaagcccttaaagaaaccaaggttcatgagacagaaacaatcacgctt gaggtagaactcagccaggctgatgttgaaggatcctggaccaaggatggggccaaatta aggccaggggcccactgccgtatcacagcccttgaaaagaagcatgcactcacactgtcc aatctcaagatggatgatgcaggaatgatcgccttccaggctgaaggcgtccacacttct gccaaacttatcgtcacagaaccacctgccactatctccaaacccatcatggacatcagt gttccggagaaggagaaggttacctttgaatgtgaagtgtctcgatcaaatgcagatgtt acatggttgaagggtgatgtggaactgaaaccgggtaaaaacctcggaatccattccttg ggcaggaagcgcactttggtcatcaacaaatgttctcctgaggatgcaggcacttacatc tgtcgcactactgatgacaacacctcggccaagctcaccgtcaatgcccgagatataaag atcatcaagaaactgcaggacctggaggtgacggagaaggagagtgctgcgttcgtctgc gagatctcacatgatgaagttgactgtcagtggtttaaaggaaatgctaaactcaaagtc ggtgaaaatgtcaagatgagacaagaagggaggacatatgtactgctgtttaaatctgtg gccccagaagacatgggtgaaattaaatttacagccgagaaggcctcatcgactgcaaaa ctcaaagttaaagagctgcctgtcaagtttgtaaagagactcagggacaagatagcgatg tacaaacatcgtggtcatctcgagtgccaggtgtcaagagccaacgctcaggtgaagtgg tacaagaacaaggtggaaatcaaacccagcaaaaagtatgagatcaaaagtgaagacgtg tacaggaaactcaccatcaatgatgtggattctggggatgaagacacttatacctgtgat gcgattgatgagaagacatcctgtaaactgcttgtagaagaacagtctatcagtattgtg cgggagcttaattcggttgaggtgacagaaccttttccagccgtgtttgaagttgaaatt agcgtggaactggtgaaacctcccgcttggacactgaatggagtcgctgtgaaagacagt gtggatgcagaaatggagaaggagggaactttgcatcgtctcattttcaaaaagaccaaa gcttccatgtctggaccggtgcagttcacggctgggaagagcaaatgtctcgcccaactc accgtcaaggagcgcccacttgaggtggcagagcctctgaaagatgtgaaagcaaaggag aagagtgctgccctgctcagctgcaagttttctgctccacctaaagaagttagctggttt aaaggccagtttcctctgtcaccgtcagataagtacaacatgaagcaggatgctacaaga gctcaactcaccattcaaatgttaaccgaggaagacaccggggagtaccactgtaagtct ggacctgcagagaccaaaggcaccctgactgtagaagtgcgtgaaattaaaatcaccaaa cacttggccgacacagaggtggaagaagacagtgatgccgtgtttacatgtgagattaac tacgcagatgaagaagcacagtggcttctgaaggataaggtgctcttcacaaacgaggtc aacaccatcacgcatgagggcaaggttcacaaactgaagctgaagaacttggcacctcag gatggtggcactatcacctttcaggttcgcaaggtcaaagagtctgtcacgctcaaggtg aaagagaaacgtgctgtcttcctcaagtctcttgatgatgtcattggtgaggtgaaagga atggtaactctggcctgtgaggcgtccaagcccagggtttctcctatttggagaaaagga ggtaaaaccttgaaggcgggatcaaagtatgagctccttcacacaggcaagtctttgggg ttgatcatcaaggacgtctccaaagatgatgctggggagtacacctgtgacctcgggact gaggtttgcaaagcaaatgtcactgtaagagagattggcatcggaataaccaaatggctg aaggcagctgaggtgaatgaaggagagacctgcagctttgagtgcatcctgtcccgtgag accaccgagtgcttgtggactctgaactccaagcctgttacagacgggggtcgtttcaat gtctcgagtaaaggccgcaaacacatgctcaccattaaagatgtcgttccgtctgacgct ggtgaggtggtcttcagtattggagatctaaactccaaaactacattaacagtagaaggc agagcctcatcggtgaccaaaggacttgaaaatgttactgctgttcagggtgaagatgcc atattcacctgctgcgtgacacattcgagtgcaactgtaaagtggaccaaggatggaaaa gccatcaagaagagccaaaagtacgacattagccaagaagataagatcaagacgctcacc gttcacaatgtctctgcacaagacgcaggggaatacagttgtgaagtgattggaggtgcg accaccagagccaaactggaaattaaagagcccatccataaatttgttaaacctttgaaa gacagccaggcagatgagaagagctctgtaactttgcagtgtgagaccgctcaagctcca tccacggtcacttggctcaaaggccacacggagctgaaggcaggaggacgctatgagatg tccaagaaagacgggcttttaactttaaccatcaaacacttggaggagggggacaccgac atctacacgtgtgacgtggtcacggctaagagcatggcaaagttgaccatcaaagcatta ccaccagtcttcacacagaagttaaaaggccaggaagccatggaaggagacaacatttct atgacctgcgagctctccaaacctgaaatcccagtggagtggaagaagggatcacaggtc ctgaggtctggacagaagtaccagataaaacagaaaggctctctccttgaactcatcatc aatgatgtcacaccagaagacagtggagactacagctgtgtgtgtggagaccagaagacc acagccaaccttaaagtcaaggcccagccagtgaccttcaaacagcagttggagagtcaa gaagcagaagaggaatccagcatcaccctgcactgtgagctctccaaacccggagtcccc gtggagtggaagaaaggatcacaggtcctgaggtctggagagaagtaccaggtgaagcga aacgcttgtgtggatgaactcatcatcaacaatgctataccagaagacagtggaaactac agctgtgagtgtggagaccagaagaccacagccaacatcaagatcaaggccaaaccagtg accttcagcaaggcattaaagggccaggaagcagacgagggatcaaggatcactctccag tgtgaactctccaaacctggagtctcagtggagtggaagaagggatcagaggtcctgaag tctggagagaagttccagataaaacagaaaggctgtgtagttgaactcatcatcaacaac gttgtaccagaagacagtggagaatacagctgtgtgtgtggagaccagaagaccacagcc aacatcaacatcaaggctgccaaactggaatcaaaaagacaagagaccaaggagaaagca gaaggtgtgcagtcagtcaaaacacatgaagccttgtcaacaacttcctctgacaaacac atgtacagggaggaaaaaatggaagctgtgactcaagttacgactggacaaactactaaa caacagctccttaaacaggacatgcacagagattcacatgaggtgaaagtgagagaggaa gctaaaacccttgaagcctcatctacagtagctgcagacaggcacacgtacagacaggag attacagaaacagtagaagttgtgactcagctcaccactggacagtctccgacacagcag ctcctccaacaggggtttcagagagagtcactgtcagttgaagctgcaaaagtggaatct aaaattcaggagtcaaaggagacagtggaagtgactcagctttctcccggactgtctctc gcacagcagctccaaagagattatttggagcaaataatgggcgttgatgctgctacactg gattcaaagagtcaagaaatgaaggaaacagcaggagtgactcagctaactactgggcag actcatacacaccacctctcagaacaggaggttcagagagatacacagcagctgacattt ggagctggagcagagaagtcagcttcaacagtatcttccagagctgaacttgagaagctg gaatctgtaaagcgagttgaagcccttccagtcaaagtcattgaacatttagagagcctg gaggctgaagaggaaagtagtgtcactctgcactgtcagctttccaaacctggactcact gttgagtggaggaaaggaagtcaaagccttagtcatggagaaaaataccaaatgagtcaa acaggtttcagttatgagctacagatccatgacttgacaccaggagacacgggaacctac gcctgctgctttgaagacgcagcaagtgccgcctctctggcagtaattgctgcgcctgtc attttcaccaaaaagctggaaaaccttgatgctaacgagggcgacagtgtgaccctcagc tgtgagctttctaaacctggtgtttctttggagtggcggaaaggagaactcggtctttgc ccttgtgccaagtatggcattagtcagaggggacacctggccacactggtaatccatgac atcgacccagaagatgctgggagttacatatgtgatgctggtgaccaacagagcactgcg aaactgtgtgtgaatgccaaaccagtactgtttaaaaattcacttcagaacgttgaaagg gaggcaggggatatagctattctgcgctgtgagacaacaaaaccaggagccagtgtggtc tggagacacggtgacactgtgctggagtccagcagcaagtatcagctgaaacaggaaggc acttcagtccagcttattatctataaactacagggagccgattcaggagagtactcctgt gacacaggcagccagaggacatcagctgtcctctccgtgcaggaggttgagattagcatt gtgaaatacttggagagctgtgttgtctacgagggagaagacgttcacttccagtgtctg atttctcacgaggacgctcctctggcccagtggaaactggagggcgtcccactacagaat aacgaaatgaacttgatcaagacaaacggtcgatcacacagcctcacactcagaagtgtc acagcagccgactcggggacagtgactttttctgtgggaaaccacacgtctacagcttct ctgacagtcaaagctgctcctgtgatattcaagaaagagttagaaaatcaagaggccact gaaaaaggcaaagccatcttttcctgtgagacctccagtgctgattgtaaggtaacctgg cggaagggctcctctgtgctaaccaatggggagaagtacacgattgagcagaacgctacc actcacaccctggttatacacaacctgagcctgaaggacagcggagaatatagctgtgac acaggagacagaaaaacaactgctgctctgactgtgaaagagtgcattcgcattgtccga gaactctgcgatactactgttatcaccggacaggacgctgtctttgaggtcgagctgtca cactcaggcgtaacagacggacaatggtggctcgaggataacctccttcaaaacaatgat ctgaatcagatgagcagccacagccgagtgcaccgtttggtgttgaagatggtgaccaca gacgagacgggcgatgttgcctttgtacttggagaagaaaaaagtgtggcctccctgctg gtggaggagaaacctaaagtggtaataatagagaagccacagaacacttttgcagtggag gacgaaaccgtcactttggtctgcactatctcggaccccaaagccaatgtcacctggaca aggaataacaagaccattcaatcaggtctcaagtacgacctgaagaaaattggagcgatc cataaacttctgatctatgacgtggtacctgcagattcgggaatatacacatgtgacacc ggagatgcacagtgtgaagtcacgctcactgtgaaaagtaccccagtgttcttcaggaag gagctaaagaaccaggatgctattgagggggatgacattgtcctgagctgtgagctttct aagtcaagtgttagtgttgagtggagaaaagggggcatggtcctccagcccaatgaaaag tttgtgatgaggaaggaagggtgtgttcaggagctgagtataaataacctggagcctgaa gacagtggctactacacatgtgacgcaggggaccaactgactacagcgtctttggctgta caagtgaaagaaatcttcattgttttgggtcttaagaccatcgacgtctttgttggggag tcagccacattctcctgccagctgtctggtagggcacctggaaaggtgcagtggtggctg gatggcactttgctgaaaaacagccctttaagtgagatagggctgagccagggacacatc tacacactcaccctaaagaatcttgccccagatgactctggcacggtcatgttcaaatct ggcaatttatcttcaactgccaagctcttagtaaaagatcccatagttgaagtggtgagc cagatggaggatcgtttggtgctcgaaaaccaaccgactgagttcatctgccagtattca aggccagtcaaggctcagtggaagaaagacgggcagccattgcagcctgatggtcgaagg gtggtagtggagcaggactggaatgtggctcgattgtacattagctgtgtgtctgctgcg gacaggggcacatacacctgtgaggcagaggggaccagtgtggtggcgtcacttcatgtg gaaggtaagcccatcaacattgttcagggactggagaatgctgagacctttgtcggaggt gaagctctgtttgagtgcgccctgtcccgtcctgagaacaaagacttccgctggtttgtt gacggcaaacccatcaaggaatctcccaattttgagattgtgacattcgagaatggccgt cgtcacctgttgctgctgaaagacttaggtcttcaagacagttgcacagtgacatttaaa gctggaacggccacttcatctgcccaactgtctgtcaaaggatggcagctggatgtggtc aagggcctggaagacaaagtagcttcagtgggtgaaaaggtggagttttctgttgagttg actgagcccatacctatggcagaagtggcctggtatgcaaacggagtggagctcaagccc agtgatctgtgggccatgagggctgatggctgttgctaccacctcatcctgaaacgggct ccacgtttgccccagcaggaaattacatttgctgctcgagatgctctctccttggccaag ctcactatcatcactgtacctgatccaccagaggacccagaggtcctcagtaaaactata aactccatcaccctctcttggtttactccactacacgatggaggcagtcccatccttggt tacaaagtggagatgcgactgctagacagcgccctctggcttccgtgccactcagaaacc gtgtgtaacacggagtttgtcgttcaaaatctcacaccgggatgtagctacaggtttaga gtagcaggcatcaacagagctgggagtggagagccagtggagctgcctcagactgtgcag cttgaggaccttactcagccaccattccgtccaggtacagaggctttacagttagagaaa gaggcgctgggtcagcccagtttgcctccagaagctgttgaagaaggtgacgtccatgat ctgtgggaggcttcagctaaaaaacgtccaatgagtcgggagcccactttggactccatc acggaacaacccgaggacgatggtaaaggtggtcagaaaaaagcacagcagaaggagacg atgtctacagaaaaagctgaagttaaatcgggggagaaggagcaggttgtcatgaagcag actgagagcaaacaggtcaccagctccgaggatgaatctggctctggaggctcatctttt ctgtcatatcttaaaaccagtagccaggccactgtctcagcaaccagtgaagcagaaacg atgaccgccgagaggttctttgcacatttccagatggcagagcagagaacagtgacgtct accaccgaagtccaaacaaccacgattcagcagacagatgtgaaacaggtgtctgtggag gatgcagacaaagtggacacaagtaaagaagacgagcctgaactcactgaagcggttatc aaaattcaagcggcttttaaaggctacaaagctcgtaaggacatgcgtcctgtgttcaaa gacactttcaaagaccagaccaaagaacccagtggcaccatacatctggagtgtgtggta gaaggtaaacctgacaaggtgcgttggctcaaagatggagagccgctgactgacgggaag cactatcatatagatatctacaacgatggcacatgttcactggtcatcactgccatcacc acaaaggatactggagtttacacttgtgaagtgaccaacaagtttggagtgacttctcac agtggtaaggtgacagtgggaacagtgagagagtcgtctgagcgacggccgctgaccgtg ggctacagtgcggacagtgagccagagagctcctctggtagtgagatggatgaatcactt aggcaggcaagcaaacgtttgaggcgcctgttacgtacacgtctcccaccagatgtcgag gaagagccgtttatcagtgcagatgaaggcgacctgcggccagatcctcactcttaccgc gaagatgacaattacatctacattcgctttgactcacgtggggatgctgaagtcgcctcc aaaaggttccaagagatgtttacaatccatggggttccagtagagacaactatccttgag gcggggtcttttaaggtggaactacgaatcaaaaaaatgggctacatacaagatggcaca cagaccccgacacaagacagacagcctcctgcattcatggctggaccccaggctgctcca gtcttcttgactgagctccaaagccaagatgttccagatggttatccagtcagttttgac tgcgttgtgatcggcaagcctccgcccactgtccgctggtataaggatggcaaattgctg gaggagaatgaccattacatgatcaatgaagacctggagggctgccaccaactgatcatt acctctgtgctgcctactgacatgggagtctatcgctgcacagctgaaaacagcagcggc atcacagccactaaggctgaactcagggttgacatgtcttgtagctcggattatgacaca gctgctgatgctacggagacatcgtcttacgtcagtgcgaagggttacatgtccagagaa actgagacatttgagtctgtggctgaggatgatcagcttccacaagttgtggaagatctt cgtgatgttcatgttagtccaggttcacctattgctaaaatgcaactcaaagtcaaaggc ttccccaaacccagaatatactggttcaaggacggccaacctctgagaccctcgaatagg atcctgttgctgacagagagagatgtgcacagtgtggagattctggaggtgaagaaagaa gatatgggagagtactccgcctacatcagcaatgcagctggttcagcttattcctcagcc agactgacagttctgagtcctggggagatcatgccacaggttaagaaagactttaaggaa ccgctggtgccaccacgcttcctggaacggttccgcaacaggaaagtgaaacaaggagcg agtatcactctgtccatcaaagtagaagggtctccgactcctcaggtgtcctggcttaaa gaggaatcaatagaagatgtcctgtggatcaagcctgataccaaaggatacaaaatagca agctctggaaacaagcacagtctgatcctgatggacgtgggcacagagtacacaggtgcc tacacctgtatagctactaataaagcaggacagtccatttgcactgcccaccttgaggtg gatgacacacaacaagtgaaaaaggagactaaagccacagatactctgggtataacagtg agtcctccagaagacgaggcaagcaccacaaaagagggtaaaataacttacctgggtgaa gtaggttcagaggagttcctcatgaaactcacctcccagatcactgagatggtgtcagcc aagatcacacaggacagcttacagaattatgaagtgctccagtggatgaaatcttggccc aaatctaccacgtcactgcgtgtaccaggggccgacagcgatgacgagaccaaaactcca tctccctctcctcatcacggtcgttcccacgctccctcactcattgctgactcctcctcg gagtctgacgagggagatgccagaggagagatgtttgacatctatgtagctacagctgac tacaaccccaccacaccaaacaaagagtccatctccctgaaggagggacagtatgtagag gttttggactcagcccatccactgaaatggctggtccggaccaaacccaccaaaaccacg ccatcccgccaaggatgggtctcacctgcctacctagacaagaagctcaaactttcagca gatgcaggtgatcttccagagacgagcgctgaggaggtttctgagggcgaatataagagg aaactattccaactgattcaggaactgatcaatggagaatcagatttcgtcaaggagatg aactttttcatctctcatcacatgaagcaagcagagagccctgacgcaccgtctgatgtc agcagccagaaagaaaccatcttcaggaacattgatgacatcaagagcttccacagcagg acgttcctgtctaggttaaacgactgtgacactgacgacgatgtagccatgtgtttcctg aaaaacagggagggctttgagaagtacctccagtatctggtcggtcagagtcaggcacaa tctactgttggtgacaaaaccattcatcacttcttcaaggagtacactgagaaggaacag gctgctgcagacccgacagaacctcctgtacgtagcatcgagacccaccttcaacaacca ctggagaggattcagaaatacaaagctttacttaaggagctcattcgaaacaaggcaaga aacggtcagaactgttgcctcctggaagaagcctatgctatggtgtctgcacttcctcag cgatctgaaaatactcaccacgtatccatgatcgagaactatcctgccacactcgaagta ctaggagaaccgattagacaaggaccgttccaagtgtgggagggagcgcctggaatcagg tcgtcctctaggggtcaccaccgccacgttttcctcttcaaaaactactgtataatctgc aaacccaagagagacagcaatacagatacacaagcctatgtctttaagaacatgatgaaa ctaaacaacattgatgtaaacgagacagtagagggtgacgaccgtgcctttgaaatctgg cacgaacgtgaagactctgttaggaaatacaccttacaggcacgaactgtgaccatcaaa aactcctggctgagagacttcagggaactgcaacagagatacagcatgcctgcatggagt cctcctgactttgatgaaatcctggcgaactgcactgcagatttgggacaaactgtaaaa ctggcctgcaaagttactggagtgcccaaacctatggtcacatggtacaaagatggacgt ccagtggaggcagatcctcaccacatcatcatcgaggaccccgatggttcctgcaccttg atcctagacaacatgacggcagatgattctggacagtacatgtgctttgccacaagctca gctggaaatgccagcactctgggaaagatcacagtccaggttcctcctcgttttgtaaat aaaataagaagtgccgtcttcattgctggtgaagatgcacagtttacctgtgtcatacaa agtgccccaagccccaagatcagatggttcaaagaaggcagactgctgactgaccaggaa aagtatcagacctacagtgagctccggagtggggttctggtcttggtgataaaaaacctg actgagagagatttgggacactatgagtgtgagctgtccaaccgtctgggcagtgccaaa tgtgctgccgacttagtcccgccctcagctgtggctcgaatgggagaacaggccgtcact attgaagttactgagcaggagacaaaaataccaaggaaaaccatcatcatcgaggagaca attaccactgtggtgaagaaccctcgtatgaggagacacagatctccaggcttgactctg gttggagcccatcgttctgaaacatccaccccagagacaccaacagccagggtgaggagg gttcctactcccaggaagaccaccatccctaccctctacgtcacacaggctgaaggcgct gaggcccgaatcatagagaccaagccaaggtgggtggaggtagaggaggtcattgagtac aaggtaaataaatctcccaggctgcccaggaggagaggcatttcacctgcaggctctgac cgtgttgccactccctccagacctaaaaggtctccacctgaaaacccaaatgctaacaat tctaacaacaagctggtggagaaggtggctcaggctgagctgcagggtgatgtcagcagt caacccctctcctgggaggaggttgctggtagtgcttcctttgttcctgcaacctcagca ccaagtgagctgtcaactgtcctcactccagctggagggaacgatgacgaactggacgac caacaaactgtcgtcgttgaacctgatgatgatggcgatgatttccagatgttcacaaag caggaaccaaagcttgtgaagcaaggaggtcatgctctgacccttgaggacttggaggat tatgttccagaagagggagaagcctacggctcctccagcatccctgtagaaaagccatgt gaggtttccgtgctgcagagggagattggtggatccactgttggtcagccggttctccta aactttggacggcctgttgtcgtgccaaggcacaggggtggcttcttcagccgcttcaaa gatcatctctccactagtcctttcaccgctgctgttccacaggcaagcaggagaaccagg gtggagaggagcgtccccatccaagtcagcaacaccaagctgaaagtgaagccgtcatac tgctctgaggtgcagagggttgagtgtgggcagcagagctttaaaaccaaggtgtcaacc cagacctacggttacacctcagttggaaaaccagtcactcttcagattcaagatcaccac tctcagaagaagtaa

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