KEGG   PATHWAY: csr00730
Entry
csr00730                    Pathway                                
Name
Thiamine metabolism - Clostridium saccharoperbutylacetonicum
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
csr00730  Thiamine metabolism
csr00730

Module
csr_M00899  Thiamine salvage pathway, HMP/HET => TMP [PATH:csr00730]
Other DBs
GO: 0006772
Organism
Clostridium saccharoperbutylacetonicum [GN:csr]
Gene
Cspa_c02090  adk; adenylate kinase Adk [KO:K00939] [EC:2.7.4.3]
Cspa_c08400  thiD; hydroxymethylpyrimidine/phosphomethylpyrimidine kinase ThiD [KO:K00941] [EC:2.7.1.49 2.7.4.7]
Cspa_c08410  thiC; phosphomethylpyrimidine synthase ThiC [KO:K03147] [EC:4.1.99.17]
Cspa_c08420  thiM; hydroxyethylthiazole kinase ThiM [KO:K00878] [EC:2.7.1.50]
Cspa_c08430  thiE1; thiamine-phosphate synthase ThiE [KO:K00788] [EC:2.5.1.3]
Cspa_c12370  iscS1; cysteine desulfurase IscS [KO:K04487] [EC:2.8.1.7]
Cspa_c12890  rsgA1; putative ribosome biogenesis GTPase RsgA [KO:K06949] [EC:3.6.1.- 3.1.3.100]
Cspa_c12910  thiN; thiamine pyrophosphokinase ThiN [KO:K00949] [EC:2.7.6.2]
Cspa_c15280  iscS2; cysteine desulfurase IscS [KO:K04487] [EC:2.8.1.7]
Cspa_c15290  thiI; putative tRNA sulfurtransferase ThiI [KO:K03151] [EC:2.8.1.4]
Cspa_c17940  dxs1; 1-deoxy-D-xylulose-5-phosphate synthase 1 [KO:K01662] [EC:2.2.1.7]
Cspa_c27480  dxs2; 1-deoxy-D-xylulose-5-phosphate synthase Dxs [KO:K01662] [EC:2.2.1.7]
Cspa_c36170  rsgA2; putative ribosome biogenesis GTPase RsgA 1 [KO:K06949] [EC:3.6.1.- 3.1.3.100]
Cspa_c46690  hydG; iron-only hydrogenase maturation protein HydG [KO:K03150] [EC:4.1.99.19]
Cspa_c48990  thiE2; thiamine-phosphate pyrophosphorylase ThiE [KO:K10810] [EC:5.3.99.10]
Cspa_c49000  thiH; 2-iminoacetate synthase ThiH [KO:K03150] [EC:4.1.99.19]
Cspa_c49010  thiG; thiazole synthase ThiG [KO:K03149] [EC:2.8.1.10]
Cspa_c49020  thiF1; thiamine biosynthesis protein ThiF [KO:K03148] [EC:2.7.7.73]
Compound
C00003  NAD+
C00018  Pyridoxal phosphate
C00022  Pyruvate
C00037  Glycine
C00068  Thiamin diphosphate
C00082  L-Tyrosine
C00097  L-Cysteine
C00118  D-Glyceraldehyde 3-phosphate
C00378  Thiamine
C01081  Thiamin monophosphate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C02892  Thiamine acetic acid
C03028  Thiamin triphosphate
C03373  Aminoimidazole ribotide
C04294  5-(2-Hydroxyethyl)-4-methylthiazole
C04327  4-Methyl-5-(2-phosphooxyethyl)thiazole
C04556  4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine
C04752  4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate
C05856  Thiamine aldehyde
C11437  1-Deoxy-D-xylulose 5-phosphate
C15809  Iminoglycine
C15810  Sulfur-carrier protein
C15811  [Enzyme]-cysteine
C15812  [Enzyme]-S-sulfanylcysteine
C15813  Adenylyl-[sulfur-carrier protein]
C15814  Thiocarboxy-[sulfur-carrier protein]
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20246  2-[(2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate
C20247  2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate
C20267  4-Amino-5-aminomethyl-2-methylpyrimidine
C20784  ADP-5-ethyl-4-methylthiazole-2-carboxylate
Reference
PMID:15614489
  Authors
Kawasaki Y, Onozuka M, Mizote T, Nosaka K.
  Title
Biosynthesis of hydroxymethylpyrimidine pyrophosphate in Saccharomyces cerevisiae.
  Journal
Curr Genet 47:156-62 (2005)
DOI:10.1007/s00294-004-0557-x
Reference
PMID:14567704
  Authors
Park JH, Dorrestein PC, Zhai H, Kinsland C, McLafferty FW, Begley TP.
  Title
Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1).
  Journal
Biochemistry 42:12430-8 (2003)
DOI:10.1021/bi034902z
Reference
PMID:22616866
  Authors
Begley TP, Ealick SE, McLafferty FW
  Title
Thiamin biosynthesis: still yielding fascinating biological chemistry.
  Journal
Biochem Soc Trans 40:555-60 (2012)
DOI:10.1042/BST20120084
Reference
PMID:12777485
  Authors
Wightman R, Meacock PA
  Title
The THI5 gene family of Saccharomyces cerevisiae: distribution of homologues among the hemiascomycetes and functional redundancy in the aerobic biosynthesis of thiamin from pyridoxine.
  Journal
Microbiology 149:1447-60 (2003)
DOI:10.1099/mic.0.26194-0
Reference
PMID:22031445
  Authors
Chatterjee A, Abeydeera ND, Bale S, Pai PJ, Dorrestein PC, Russell DH, Ealick SE, Begley TP
  Title
Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase.
  Journal
Nature 478:542-6 (2011)
DOI:10.1038/nature10503
Reference
PMID:19348578
  Authors
Jurgenson CT, Begley TP, Ealick SE
  Title
The structural and biochemical foundations of thiamin biosynthesis.
  Journal
Annu Rev Biochem 78:569-603 (2009)
DOI:10.1146/annurev.biochem.78.072407.102340
Related
pathway
csr00010  Glycolysis / Gluconeogenesis
csr00230  Purine metabolism
csr00260  Glycine, serine and threonine metabolism
csr00270  Cysteine and methionine metabolism
csr00400  Phenylalanine, tyrosine and tryptophan biosynthesis
csr00750  Vitamin B6 metabolism
KO pathway
ko00730   

DBGET integrated database retrieval system