Crotalus tigris (Tiger rattlesnake): 120307182 Help Entry 120307182         CDS       T08476                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism ctig  Crotalus tigris (Tiger rattlesnake) Pathway ctig04020   Calcium signaling pathway ctig04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:ctig00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     120307182 (RYR3)    04020 Calcium signaling pathway     120307182 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:ctig04040]     120307182 (RYR3) Ion channels [BR:ctig04040]  Voltage-gated cation channels   Ryanodine receptor    120307182 (RYR3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  120307182 NCBI-ProteinID:  XP_039197516 LinkDB All DBs Position Unknown AA seq 4895 aa AA seqDB search MAEGGEGGEDEIQFLRTDDEVVLQCVANIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVP PDLCICNFVLEQSLSVRALQEMLAHTRDNSREGFIRKATQGGGHRTLLYGHAVLLRHSFS GMYLTCLTTSRSQTDKLAFDVGLQENAIGETCWWTIHPASKQRSEGEKVRIGDDLILVSV SSERYLHLSVAYGNIQVDASFMQTLWNVHPTCSGSNIEEGYLLGGHVLRLFHGHDECLTI ASTEQNDSPHKRVFYETGGAGVRARSLWRVEPLRISWSGSHIRWGQPFRLRHITTGQFLA LTEDLGLVLLDREKADTKSTSFCFRASKEKLDSAHKRDIEGMGFPEIKYGDSVCFVQHVA STLWLTYKAQDAKTSRLGPLKRKVILHQEGHTDDGLSVQRCQHEESQAARIILNTTKLFS QFISGNNSVTTPITLPIEEVVQTLQDLITYFLPPEEELEHEDKQNKLRSLKNRQNLFKEE GMLALVLNCIDRLNVYYSTAHFTGVGREENGAAWKEILNLLYKLLAALICGNRNNCAQFS NNLDWLISKLDRLESSSGILEVLHCILIESPEALNLIDEGHIKSIISLLDKHGRNHKVLD VLCSLCLCNGVAVRANQNLICDNILPRRDLLLQTRLVNDVTSIRPNIFLGIAEGSAQYKK WYFELIIDQVEPFLTAKPTHLRVGWASTSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHL WSGRIPRAVASVNQHLLASDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVV SFSAGVKVRFLMGGRHGEFKFLPPTSYAPCYEALLPKEKMKLEPVKEYKRDSEGIRDLLG TTQFLSKANFIPCPIDTNQIVLPFHLEKIRDKLAENIHELWGMNKIELGWTYGKIRDDNK RQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHVVHVNPGAEEDLKKIKLPKNYMM TNGYKPAPLDLSEVKLLPSQEILVDKLAENAHNVWAKERIKQGWTYGIQQDLKNKRNPRL VPYVLLDERTKKSNRDSLREAVRTFAGYGYNIEAPDLELADQTVEKVSIDKIRFFRVEKS YAVKTGKWYFEFEAVTGGDMRVGWARPGCQPDIELGADDQAFVFEGSKGQRWHQGSGFFG RNWQVGDVVGCMINLEDKSIIFTLNGELLITNKGSELAFADFEIDNGFVPICSLGLSQIG RMNFGRDASTFKYYTMCGLQEGFEPFAVNMNREVAMWFSKRLPTFVNVPKGHPHIEVTRI DGNIDNPPRLKVTHKTFGTQNSNADMIYCRLSMPIEFHSSFTYSHGFEFEGFYKRKQNQE IPIHTTTYYYLVKIFAGQDPSSVWIGWVTPDYHFYSEHFDLNKNCTVTVTLGDERGRVHE SVKRSNCYLVWGGESFVNSQRSNRGNVDLEIGCLVELATGMLSFTANGKELGTFYQVEPN TKLFPAVFLQPTSTHLVQFELGKLKNTMPLSAAIFKSEERNPIPQCPPRLDVQTLTPVVW SRMPNSFLKVEIDRVSDRHGWLVQCQEPLQMMALHIPEENRCIDILELCEQEDLMRFHYH TLKLYSSVCALGNNRVAHALCSHVDVSQLFYTIDNRYLPGLLRSGFYDLLISIHLEYSKE AKLMMNNEFITPVTDETRKIRLFPDGSKKHGLPGVGLSTCLKPKFKFSTPCFILSNDDHQ KPSPEIPLEILKTKTISMLTEAVYCSGAHIRDPVGGKVEFQFVPVLKLIGTLLRMGVFDD HDVKQILLLIEPCVFGESKEDIMEQAEKEDLSQIEEKAVEAGEKAIKETKTPIKGLLQTR LPESVKLQMCELLNYFCDCELKHRVEAIVSFADTFVLKLQYNQKYRYNELMQALNMSAAL TARKTKEFRSPPQEQINMLLNFQLGEDYPCPVEIREELYEFHDKLLIHCGIPLEEEKEEE ENISWAGKLCSLIYKIKGIPKTEKREATEEEEKYPTSLKELISQTMVRWAQEDQIQDPEL VRIMFNLLRRQYDSIGELLQALRKSYTISAASVQDTINLLAALGQIRSLLSVRMGKEEEL LMINGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKSQIAFPKMVASCCRFLC YFCRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALEEPD LEKVVTYLAGCGLQSCQMLLAAGYPDIGWNPIEGERYLSFLRFAVFVNGESVEENACVLV KLLIRRPECFGPALRGEGGNGLLAAMQEAIKISENPALDLTSQGSKRKFLEEDEEEEEIV HMGNAIMSFYSALIDLLGRCAPELHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKL PTINKDGTVTEPNMSATFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRACASL DTISLSTTETALALNRYICTAVFPLLTRCASLFLGSEHYMSLIDSALHTIYRLSKGRSLT KAQRDTIEECLLAICHHLRPSMLQQLLRRLVFDVPLLNEYCKMPLKLLTNHYEQCWKYYC LSSGWGNYGTAAEEELHLTEKLFWGIFDSLSHKFLSLLQKYDPELFRMALPCLSAIAGAL PPDYLDTRITSFLEKQMSVDAEGNFDPKPISTLNFILPEKLEFIVNKYAEHTHEKWACDK SNCGWKYAPLLDENTKIHPLIRPFKTLTEKEKEIYRWPARESLKTMLAMGWSLERNKEGE NMTQQRENEKLRSISQSSQGNSYSPAPLDLSNVVLSRELQGMVEVIAENYHNIWAKKKKI ELENKGGGGHPLLVPYDTLTAKEKARDREKAQELFKFLLVNGIVISRGLNDLELDASSME KRFAYKFLKRILKYIDSAQEFIAHLAENKFNRMQKKEAIVTSGKTEKSPHDQEIKFFAKV LLPLVDQYFTNHCLYFLSSPTKPLGSSGYASNKEKEMVASLFCKLAALVRHRISLFGSDA ATMVSCLHILAQTLDTRTVMKSGSEMVKAGLHAFFENAAEDLEKTSENLKLGKFTHSRTQ IKGVSQNINYTTVALLPILTSIFEHVAQHNFGTDLLLNDVQISCYRILCSLYSLGTGKNI YVERQRPALGECLASLVAAIPVAFLEPSLNLYNPLSVFNTKSAREKAILGMPETVEEMCP EIPHLDGLMKEINSLAESGARYTEMPHVIEVILPMLCNYLSYWWEKGPENNAESDGSCCT MVTSEHLSIILGNILKIINNNLGIDEATWMKRIAVYAQPIISKARPDLLKSHFIPTLEKL KKKAIKIVIEEEQLKADNKTDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLK KPDADSDELFRMVAEVFILWCKSHNFKREEQNFVVQNEINNLAFLTGDNKSKISKQIAPR GMAMQVKSGGHDQERKKAKHRGDLYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKS RYSCKDTEEEVKEHLRNNLHLQEKSDDPAVKWQLNLYKDVLKTDEPTDPEKTIERVQRIS AAVYHLEQVEQPLRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQKY WIETEEYSFEERLVQDLAIPPKTTEEEEEEDEKHPDPLHQIILHFSRSALTERSKLENDP LYTAYSAMMAKSCQSGQDNNEEEEEEEKEKTFEEKEMEKQKTLYQQSRLHERGAAEMVLQ MISASKGEMGPMVVETLKLGIAILNGGNSVIQQKMLDYLKEKKDAGFFQSISGLMQSCSV LDLNAFERQNKAEGLGMVTEEGTLIIRERGEKVLQNDEFTKDLFRFLQLLCEGHNNDFQN YLRTQMGNTTTVNIIISTVDYLLRLQESISDFYWYYSGKDIIDESGQHNFSKALAVIKQI FNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIKLLKELLDLLK DMVVMMLSLLEGNIVNGTIGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTSSEAFKEYD SEGKGIISKKEFQKAMEGQKQYTQSEIDFLLSCAETDENDMFNYVDFVERFHKPAKDIGF NVAVLLTNLSEHMPNDSRLQTLLHPAESVLNYFEPYLGRIEIMGSAKKIERVYFEISESS RTQWEKPQVKESKRQFIFDVVNEGGEQEKMELFVNFCEDTIFEMQLASQISETDTVDRVE EEEENEVCYLREVGEDEKEEQSFESASAFAMACDAVKKYAATILKIIRLKNLRKQYRKVK KMTFKELVKVSFSSLWMLFIGVFQMFFAIIWSVFQILWSTVFGDGLVEGAKNIRVTKILG DMPHPTQFGIHEDVLEAEKVEVLEHGIAAEIVQFVKKEKGETDILSDIFDIYSKKESGSK HGHDIGLGDIASIIGSETPPSLESAVRKKKKIQLPELTRDDDSETRTESEKADMEDGEKH DKIKDEVYSEYLEAEEPKKRKRHGQKLEKPEAVMANFFKVLEIYQTKVLHYLARNFYNLR FLALFVAFAINFILLFYKVTEEPFEEMEEDSDLWQSLDEDEDEEGMVFFVLQESTGYMAP TLRALAVIHTIISFLCVIGYYCLKVPLVVFKREKDIARKLEFDGLYITEQPSEDDIKGQW DRLVINTPSFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKNALDFSPVEHTEPDEA SFVSWLSSIDAKYQIWKLGVVFTDNSFLYLAWYTTMSILGHYNNFFFAAHLLDIAMGFKT LRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTC YLFHMYVGVRAGGGIGDEIEDPAGDPYEIYRIVFDITFFFFVIVILLAIIQGLIIDAFGE LRDQQEQVKEDMETKCFICGIGNDYFDSTPHGFEMHTLQEHNLANYLFFLMYLINKDETE HTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14688 nt NT seq  +upstreamnt  +downstreamnt atggctgaagggggcgaaggaggggaagacgagatacagttcctacgaactgatgatgaa gttgtacttcagtgtgtagccaacattcataaagaacaacgcaagttctgcctggctgct gaggggcttggaaatcggctctgctttttggaaccaacctcagaagctaaatatgtccct cctgatctttgcatctgtaattttgtactggaacagtctttatctgtcagagccctccag gaaatgcttgcccatacaagagacaattccagggaagggtttataagaaaggcaactcaa ggaggtggtcacagaactctgctgtacggccatgcggttctgcttcggcattctttcagt ggaatgtatttgacatgtttaacaacatcaagatctcagacagataaacttgcatttgat gtgggcctacaggaaaatgcaataggtgaaacatgttggtggaccatacaccctgcttct aaacaaaggtcggaaggagaaaaggtacggattggagatgatcttattctagttagcgtg tcctcagaaagatacctgcatctttctgtggcatatggaaacatacaggtagatgcttcc tttatgcaaacactctggaatgtgcaccctacttgttcaggaagcaacattgaagaagga tacctacttggtggtcatgtattacgtttatttcatggccatgatgaatgcttgaccatc gcatctacagaacagaatgattcaccacataagcgggttttttatgaaactgggggagct ggagtccgtgcaagatcactatggagagtggaacctcttcgaataagctggagtggaagt catatccgctggggacaaccatttcgccttcgacatattacaacaggacagtttttagcg ttaacagaagacctaggtcttgtcttattagacagagaaaaagctgacacaaaatcaact tccttttgttttagagcatccaaggaaaaattggattctgctcacaaacgtgatatagag ggcatgggatttcctgaaataaaatacggagattctgtttgttttgtgcagcatgtagct agcactttgtggctgacttacaaagcacaggatgctaaaacatcacgtttaggaccactg aaaagaaaggttatattacaccaagaagggcacacagatgatggactgtctgtgcaaagg tgtcaacatgaagaatcccaggctgctagaattattctcaataccacaaagttattcagt caatttataagtggaaacaacagtgttacaactcccatcactcttcccattgaagaagta gttcagactctccaagatttaattacatattttctacctccagaagaagagctagaacat gaggataaacaaaacaaacttcgttcccttaaaaacagacagaatctattcaaagaggag gggatgctggcattggttctgaactgcattgatcgattaaatgtatactatagtactgct cattttacaggggttggtagagaagaaaatggtgcagcgtggaaagaaattctaaatctt ctttacaaattattagctgctctcatttgtggtaacagaaataattgtgcccagttttcc aataatcttgattggttgattagtaaattggacagactagaatcttcttcaggtatttta gaagtattgcactgtatattgattgaaagcccagaagctttaaatttgatagatgaaggt catataaaatccatcatctccctgctggataagcacgggcgcaaccataaggttcttgat gtcctgtgctctctttgtctctgtaatggagtagcagtgcgtgctaaccagaatttaata tgtgacaatattcttcctcgaagagatctgctcttgcaaacacggctggtgaacgatgtg acaagcataaggccaaacatatttcttggaattgctgagggctcagcacagtataagaaa tggtactttgaactaatcattgatcaagtggaaccatttttgacagcaaaaccgacacat ttgcgggttggatgggcctcaacatcaggctacgctccttatcctggaggtggggaagga tggggaggaaatggtgttggtgatgacctgtactcctatggttttgatggacttcatctc tggtctggtcgaatacccagggctgttgcatctgtgaatcagcatttattagcatctgat gatgtggtcagctgttgcttggatttaggggtccccagcatttctttccgtattaatgga caacctgtgcaaggaatgtttgaaaactttaatactgatggccttttttttcctgtggtg agcttctcagctggtgtcaaagtgcgtttcttaatgggtggccgtcacggagaattcaag tttttacctcctactagctatgcaccttgctatgaagctttgcttccaaaagaaaagatg aaattggaaccagtaaaagaatataagagggattctgaaggaattagagatttgcttggt actactcagtttctttccaaggctaattttattccttgtccaattgataccaatcagatt gttttgcctttccatcttgaaaagattagagacaagcttgctgaaaatattcatgaactc tggggaatgaataaaatagaacttggttggacctatggcaagatacgagacgataataaa aggcagcatccttgtctggtggaattttcaaaattgcctgaaacagagaagaactataat ctgcaaatgtcaaccgaaactctaaaaactcttttggcccttggatgccatgttgttcat gtgaatccaggggcagaagaagatcttaagaaaatcaagcttcctaaaaattacatgatg acaaatgggtacaagccagctcctcttgatctttctgaagttaaattgttaccttcacaa gaaatattagttgataaacttgcagagaatgcacataatgtctgggcaaaagaaagaata aaacaaggctggacctatggtattcagcaggatcttaaaaacaaacggaatcctcggctg gttccttatgtgttattggatgaacgcactaaaaagtcaaatagagatagtcttcgtgag gctgttcggacctttgctggatatggatataatattgaggccccagatctggaactagct gaccaaacagtggaaaaagtgagcattgataagatacgtttcttcagagtggagaaatct tatgcagttaagactggaaagtggtattttgaatttgaagctgtaactggaggggatatg cgtgttggatgggcaagaccaggctgccaacctgacatagaactaggagctgacgaccaa gcatttgtattcgaaggctccaaagggcaacgttggcatcaggggagtggattctttgga cgaaactggcaagtaggagatgtagtgggctgtatgatcaatctggaggacaagtctatt atatttacactcaatggagaattacttataaccaataaaggttcagaacttgcttttgct gactttgaaatagataatggttttgttcctatatgctcactgggtttgtctcagattggt cgaatgaattttggaagggatgccagcactttcaaatactacacaatgtgtgggcttcaa gaaggttttgagccttttgctgtcaacatgaacagagaagttgctatgtggtttagcaaa cgcttaccgacctttgtcaatgtgccaaaagggcatcctcatattgaggttacaagaatt gatggaaacattgacaatccaccacgtttaaaagttactcataagacatttggaacacag aatagtaatgcagacatgatatattgtcgcttgagcatgccaattgaatttcattcatct tttacctacagccacggtttcgaatttgagggtttctacaaaagaaaacagaaccaggaa atacctattcataccacaacatattactacttagtgaagatctttgctggtcaagacccg tcttcagtctggattggttgggtaactcctgactaccacttttacagtgaacattttgac ctaaataagaattgcacagtaacagttactttgggagatgaaagagggagagtccatgaa agtgtgaaacgtagtaattgctatctggtttggggaggagaatcatttgttaattctcaa agatcaaatcgtggtaatgttgacctagaaattggatgtcttgtcgaattagctactggg atgttgtcattcacagccaatggaaaagaactgggaactttctatcaggttgagccaaac acaaaactatttccagctgtttttttacagcccacgagcacacacctggtacagtttgaa ctgggtaaattaaagaacaccatgcctttatcagctgcaatttttaaaagtgaagagaga aatcccattcctcagtgccctcctaggctggatgttcaaacactcacaccagttgtctgg agcagaatgccaaacagtttcctgaaagtagagattgatcgtgtcagtgaccgccatgga tggctagtacaatgccaggaaccattgcaaatgatggcccttcatattccagaagaaaac aggtgtattgacatattggaattgtgtgaacaagaagatttgatgaggttccactatcat actttaaagctatatagttctgtttgtgctctgggtaataatagagtagctcatgctctt tgcagccatgtggatgtttcccaattattttacacaatagataatcggtatttgcctgga cttttaaggtctggattctatgacttattgattagcattcatttagaatattccaaggaa gcaaaactcatgatgaacaatgaatttatcactcctgttacagatgaaaccaggaaaatc cgattatttccagatggatcaaagaaacatggcttgcctggagttggacttagcacatgc ttgaaaccaaagtttaaattctctactccttgtttcattttgtccaatgatgatcatcaa aagcctagtccagagataccactagagatcctgaagacaaagactataagcatgttgaca gaagcagtctactgcagtggagcacatatacgagaccctgttggagggaaagttgaattc caatttgttcctgtcctgaaacttataggaactttgcttaggatgggagtttttgatgat catgatgttaaacagattttgcttctgattgaaccatgtgtatttggtgagagcaaagaa gacataatggagcaagcagagaaagaggatcttagccaaatagaagaaaaagcagtagag gctggtgaaaaggccattaaggaaactaagaccccaataaagggcttactgcaaacaaga ttgccagagtcagttaaacttcagatgtgtgagctgctcaattacttctgcgactgtgag ctgaaacacagagtggaagctattgtgtcatttgcagatacctttgtcttaaagttacag tataatcagaaatacaggtataatgaactgatgcaagccttgaatatgtctgccgcgctg actgccaggaagacaaaggaatttcgctctcctcctcaagagcagattaatatgctactg aattttcaattgggggaagattatccttgtccagtggagattcgggaagagctatatgag tttcatgataagctcctaattcattgtggtattccattagaagaagaaaaagaagaagaa gaaaatatttcatgggctggaaaactatgttctttgatatataaaataaaaggaatacca aaaacagaaaagagagaggcaacagaagaagaagaaaaatatcctacttctctgaaagag ctgatatctcaaactatggttcgctgggcacaggaagatcagatccaagatccagaatta gttcgcattatgtttaacttacttcgaaggcagtatgatagcattggtgagctgctgcaa gctctgagaaaatcttatactataagcgctgcctctgtgcaagacacaatcaacttatta gcagcactgggacaaattcgttcacttctcagtgtcagaatgggaaaagaagaagaatta ctgatgattaatggcctaggagatataatgaacaacaaagtattttatcagcatcctaat ctcatgagagtcctgggtatgcatgagacagttatggaagtaatggtaaatgtgcttgga ggagacaaatctcagattgcttttcctaaaatggtagcaagttgttgtcggtttctttgc tatttttgccggatcagtcgtcaaaaccaaaaagccatgtttgagcatttaagctactta cttgaaaatagcagtgttggacttgcttctccttctatgagagggtccactccattagat gtagcagctgcttcagtaatggacaataatgagcttgcacttgcattggaggagcctgac ctagaaaaagttgtaacctacttggcaggatgtggtcttcagagctgccaaatgctttta gcagctggataccctgatattggttggaatcccatagagggtgaacggtatctctcattc ttaagatttgctgtctttgttaatggtgaaagtgttgaagaaaatgcctgtgtccttgta aagcttcttattcgacggccggaatgttttggccctgctctcagaggagaaggagggaac ggtctgttagctgctatgcaggaagcaattaaaatttctgagaacccagctctagatctg acttctcagggttctaagagaaaatttttagaagaagatgaggaagaggaagagatagtc cacatgggcaatgcaataatgtctttctattcagctcttatagatttgcttggccgttgt gcaccagaactccatcttatccaaactgggaaaggtgaagccattagaatacggtcgatt ttgcgttcccttgtgccaacagaagatttagttggaattataagtattccattaaaacta ccaacaataaacaaagatggaaccgtcactgagccaaatatgtctgcaactttctgtcct gaccacaaagcacccatggtgctttttctagatcgtgtctatggtataaaggaccaaacc ttcctccttcaccttttggaagttggatttttaccagatttaagggcatgtgcttcattg gatacaatttctctaagtaccaccgagacagctcttgctctaaatagatatatttgcaca gctgtgttcccattactcacacggtgtgcttctctctttttgggatctgagcattacatg tctctgattgattctgctcttcatacaatatatcgtctgtccaaagggcgctctcttacc aaagcacaaagagacacaattgaagaatgcttgcttgctatctgccaccacttacggcct tcgatgctacaacaacttctacgacgattagtttttgatgtacccttacttaatgagtac tgtaaaatgccattaaagcttctaacaaatcactatgaacaatgctggaaatattattgc ttgtcttcaggatggggcaattatggaacagcagcagaagaagaattacatttgactgaa aaactattctggggaatatttgattccctctctcataagttcctatctctcctgcagaag tatgatccagagctcttccgaatggccttgccttgtttaagtgcaatagctggtgctttg ccaccagattatttagacactcgaattacctcatttttagaaaagcagatgtcagtggat gctgaaggaaattttgatcccaaacctatcagcacgctgaattttatactccctgaaaag ttggagtttattgtcaacaaatatgctgaacatactcatgaaaaatgggcttgtgacaag agtaattgtggatggaaatatgctcctttacttgatgaaaatacaaagatacatccttta ataagacctttcaaaaccttgactgaaaaggaaaaggaaatctatcgatggcctgccaga gaatctctaaaaaccatgttagcaatgggatggagtcttgaaagaaacaaggaaggagaa aatatgactcagcaacgtgaaaatgaaaagctccgtagcatatcacaatctagtcagggg aatagctacagcccagcacctcttgatctttcaaatgttgtactttccagagaactccag ggaatggtagaagtaatagcagaaaactatcataacatttgggcaaaaaagaagaaaatt gaattggaaaataaaggaggaggtggtcatccattgttggtcccttatgacacattgaca gccaaagaaaaagctcgagatagggagaaagcccaagaactattcaaatttcttcttgta aatggcattgtcatatctagaggcttaaacgacctggaattggatgcttcatcaatggaa aagaggtttgcttataaatttctcaaaaggatccttaaatatattgactcagctcaagaa ttcattgcacatttagctgaaaataaatttaacagaatgcagaagaaagaagccattgtt actagtggaaaaactgagaaatctccacatgaccaagaaatcaaattctttgccaaagtt ctgctaccattagttgaccagtatttcaccaatcattgcttgtacttcctctcttcccca acaaagccgcttggtagtagtggatatgcttccaataaagaaaaagaaatggtagcaagc cttttctgcaaacttgcggctcttgttagacataggatttccctgtttggtagcgatgct gcaacaatggttagttgcctacatatcttagctcagacactagatacaagaacggtcatg aaatctggttcagagatggttaaagcaggattgcatgccttctttgaaaacgctgcagaa gatctagagaagacatcagaaaaccttaaacttggaaaatttacccactcccgaactcag attaaaggagtctcacaaaatatcaattatacaacagtggcactgctgcctatcttaaca tccatttttgaacatgttgctcagcataattttggtactgatttgcttttaaatgatgtc caaatttcatgttacagaattctttgtagtctgtactctcttggaactggaaagaacatt tatgttgaaaggcaaagaccagctcttggcgagtgcttagcttctcttgtagcagcaatt ccagtagccttccttgaaccttctctcaatctttacaatcccctctctgtcttcaacaca aagtcagccagagagaaagctattttaggcatgcctgagacagtagaagaaatgtgtcca gaaatccctcatttggatggcttaatgaaagaaataaatagtttggctgaatctggagcc aggtatactgaaatgccacatgtaattgaagtgatcttgcccatgctgtgcaactatctg tcatactggtgggaaaaaggacctgaaaataatgcagagagtgatggatcttgctgcaca atggtaacctctgagcatcttagtataatactggggaacattttgaaaatcatcaacaat aacttgggaatagatgaagcaacctggatgaaaagaattgcagtgtatgctcagccaatc ataagtaaagccagaccagatctgttgaaaagtcattttattccaactctggaaaagcta aagaagaaagccattaaaatagtgattgaagaagaacaattgaaagcagacaataaaact gatacccaagaagcagagcttctcattctagatgaatttgcagttctttgtcgagatctg tatgcattttatcctatgttgatccgctatgtagacaacaacagatcaaactggcttaaa aaaccagatgctgattctgatgaacttttccgaatggtagcagaggttttcatcttgtgg tgcaaatcacataattttaagagagaagaacaaaattttgtggttcagaatgaaattaac aatttggcatttttgacaggtgacaataagagcaagatatcaaaacagattgctccgagg ggaatggccatgcaagtaaagtctggaggtcatgatcaagaacgaaaaaaagcaaaacat agaggggatttatattcaatacagacttctctgattgtagctgcacttaaaaaaatgctc cccattgggttgaacatgtgtacccctggagatcaagagctaatttctcttgctaagtcc aggtacagctgtaaagacactgaagaagaagttaaagaacatttacgcaataacttgcat ttgcaggaaaagtcagatgaccctgccgtgaaatggcagttgaatctctacaaagatgtc ttgaaaaccgatgaacctactgatcctgagaaaactattgaacgtgtgcaaaggatctca gcagctgtctatcatctggagcaggttgagcaaccattaagatcaaagaaagcagtttgg cacaaactcttgtctaaacaacgtaaaagagctgttgtagcttgtttcaggatggcacca ctgtataatctgccaaggcaccgttctattaacctgttccttcatggttatcagaaatac tggatagaaacagaggaatattcctttgaggagagactagttcaggatttggctatacca cccaaaacaactgaagaagaggaagaagaggatgaaaaacatccagatcctctacatcag attattcttcatttcagtcggagtgctctcactgaaagaagcaaactagaaaatgatcct ttgtacacggcatattcagcaatgatggcaaagagctgtcagagtggacaagataataat gaggaagaggaagaagaagaaaaggagaagacatttgaagaaaaagaaatggagaagcag aaaaccctctatcaacaatcccgactccatgaacgtggagctgctgaaatggtattgcag atgatcagtgccagcaaaggtgaaatgggacccatggtagttgaaactctgaaacttggt attgctattctaaatggaggtaactccgtcattcaacagaaaatgttggattatttgaaa gagaaaaaggatgctggtttttttcaatctatctctggcttaatgcaatcttgcagtgtt cttgatttgaatgcctttgagagacaaaataaagcagaaggccttggaatggttaccgaa gaaggaacactcatcatacgtgagcgtggtgagaaagtactacagaatgatgagtttact aaagatctatttagatttttacaactgctgtgtgaaggtcataacaatgattttcagaat tacctgcgaacacaaatgggcaataccacaacagtgaatattatcattagcacagttgat tatcttttgcggcttcaggaatcaatcagtgacttttattggtactattctggcaaagat ataattgatgaatctggacaacataacttctctaaggcattggctgtaatcaaacagatt tttaattcactaactgaatatatacaagggccttgcattggaaatcagcagagtttggct cacagtagactgtgggatgcagttgttggttttcttcatgttttcgcgaacatgcaaatg aagctttcacaggattccagccaaattaaactgctaaaggagttactggatcttctaaag gatatggtggtgatgatgttgtcactacttgaaggtaacattgtaaatggcacaattgga aaacagatggtagatacacttgtcgagtcatctagcaatgtagaaatgattttgaagttc tttgacatgtttctcaagctgaaagatttaacaagctcagaagccttcaaagagtatgat tcggaaggaaaaggaataatctcaaagaaggaatttcaaaaagccatggaaggtcagaag caatatacacaatcagaaattgactttctgctgtcctgtgcagaaactgatgaaaatgac atgttcaactatgttgattttgttgaaagatttcacaagccagccaaagatattgggttt aatgtggcagtgctcctaacaaatctctcagaacacatgccaaatgattcacgccttcaa actttattacatccagcagaaagtgtccttaattattttgaaccatatttgggacgcatt gagatcatgggtagtgccaagaagatagaacgagtttattttgaaattagtgaatccagt aggacacagtgggaaaagccccaagtgaaagaatcaaagaggcagtttatttttgatgtt gtaaatgaaggtggagagcaagaaaaaatggagctttttgtaaatttctgtgaggacacc atttttgaaatgcagttggcatctcagatctctgaaactgatacagttgacagagttgag gaggaggaagagaatgaagtttgctatttgagggaggttggagaagacgagaaagaagaa caatcttttgaatcagcttcagcatttgccatggcatgtgatgcagtaaagaaatatgct gccacaatactcaagataattagactgaaaaatttaaggaaacagtatagaaaagtgaaa aaaatgacctttaaagaactggtgaaagtgtccttttcttctctttggatgctatttata ggagtcttccaaatgtttttcgctataatatggagcgtttttcagattctttggagtact gtgtttggcgatggtctagttgaaggagccaaaaatataagagttaccaaaattctagga gacatgcctcatccaacacagtttggaattcatgaggatgtgctcgaagcagaaaaagtg gaagttttggaacatggcattgcagctgaaattgtgcagtttgtaaaaaaagaaaaagga gaaactgacatcttatcagatatttttgatatttattcaaaaaaagaaagtggatcaaaa catggtcatgatattggccttggggacattgctagtattattggatcagaaacacctcct tctttggaaagtgcagttcgtaagaagaagaaaattcagctacctgaacttacaagggat gatgattcagaaacaagaacagaatctgagaaggctgacatggaggatggtgaaaaacat gataaaataaaggatgaggtatattctgaatacttggaagctgaagaacctaagaaaaga aaacgacatggacagaagttagagaagccagaagcagttatggctaatttttttaaagta ctggagatttatcagacaaaagttttgcactatttggcaagaaatttttacaatttaaga tttcttgcactttttgttgcctttgctatcaattttattctcctcttttacaaggtgaca gaagaaccatttgaagaaatggaagaagattctgatttatggcaatctttagatgaagat gaggatgaagaaggaatggtgttctttgtcttacaagagagcacaggctacatggcacct acacttagggcactagctgttattcatactattatttctttcctatgtgtaattggatac tattgtttaaaggttcccttggttgtattcaaacgtgaaaaagacattgctaggaagcta gaatttgatggtctatatattactgaacaaccatctgaagatgatattaaaggacagtgg gatcgtttagtcataaacactccatcttttccaaataattattgggacaagtttgtgaaa cgaaaggtaatcaataagtacggtgatttatatggagcagagcgcattgcagaactctta ggtttggacaaaaatgctctggattttagtccagtggaacatactgaaccagatgaagca tcttttgtttcatggttaagttctattgatgcaaaatatcaaatctggaaacttggtgta gttttcactgataattctttcttgtacttagcttggtatacaaccatgtccattcttggc cactacaacaacttcttcttcgctgctcatttgctcgatatagctatgggttttaagact ttacgtaccattctgtcatctgtaactcacaatggcaaacagctcgtgttgacggttgga ctcttggctgtggtggtatatctttacacggttgttgcatttaatttcttccggaaattt tataacaagagtgaagatgaggatgagccagacatgaaatgtgatgatatgatgacttgt tacctgttccatatgtatgtcggggtacgagcaggtggaggtattggagatgaaattgaa gaccctgcaggagacccttatgaaatatatcgaattgtttttgatatcacgtttttcttc tttgtcattgttatcctactggccatcattcaaggtcttattattgatgcctttggtgaa ctaagagatcagcaagagcaggtcaaagaagacatggagaccaaatgctttatttgtgga attggtaatgattattttgattcaacgccacatggttttgaaatgcatactctacaagag cacaatctggccaactacttgttctttttgatgtatcttattaataaggatgaaactgaa cacactgggcaggagtcatatgtatggaaaatgtaccaagaaagatgctgggatttcttc ccagctggagactgcttccgtaaacagtatgaagatcagcttggataa

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