KEGG   PATHWAY: dau00020Help
Entry
dau00020                    Pathway                                

Name
Citrate cycle (TCA cycle) - Candidatus Desulforudis audaxviator
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
dau00020  Citrate cycle (TCA cycle)
dau00020

Ortholog table
Module
dau_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:dau00020]
dau_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:dau00020]
Other DBs
BSID: 64024
GO: 0006099
Organism
Candidatus Desulforudis audaxviator [GN:dau]
Gene
Daud_1038  Isocitrate dehydrogenase (NAD(+)) [KO:K00030] [EC:1.1.1.41]
Daud_2075  pyruvate flavodoxin/ferredoxin oxidoreductase domain protein [KO:K00174] [EC:1.2.7.11 1.2.7.3]
Daud_1608  pyruvate flavodoxin/ferredoxin oxidoreductase domain protein [KO:K00174] [EC:1.2.7.11 1.2.7.3]
Daud_1607  thiamine pyrophosphate enzyme domain protein TPP-binding [KO:K00175] [EC:1.2.7.11 1.2.7.3]
Daud_1606  pyruvate ferredoxin/flavodoxin oxidoreductase [KO:K00177] [EC:1.2.7.3]
Daud_2072  4Fe-4S ferredoxin, iron-sulfur binding domain protein [KO:K00176] [EC:1.2.7.3]
Daud_1609  4Fe-4S ferredoxin, iron-sulfur binding domain protein [KO:K00176] [EC:1.2.7.3]
Daud_1249  L-aspartate oxidase [KO:K00239] [EC:1.3.5.4 1.3.5.1]
Daud_1930  succinate dehydrogenase or fumarate reductase, flavoprotein subunit [KO:K00244] [EC:1.3.5.4]
Daud_1931  succinate dehydrogenase and fumarate reductase iron-sulfur protein [KO:K00245] [EC:1.3.5.4]
Daud_1929  fumarate reductase, cytochrome b subunit [KO:K00246]
Daud_1254  hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit [KO:K01677] [EC:4.2.1.2]
Daud_1253  hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit [KO:K01678] [EC:4.2.1.2]
Daud_1121  malate dehydrogenase, NAD-dependent [KO:K00024] [EC:1.1.1.37]
Daud_1563  Phosphoenolpyruvate carboxykinase (ATP) [KO:K01610] [EC:4.1.1.49]
Daud_1962  pyruvate flavodoxin/ferredoxin oxidoreductase domain protein [KO:K00169] [EC:1.2.7.1]
Daud_1966  pyruvate flavodoxin/ferredoxin oxidoreductase domain protein [KO:K00169] [EC:1.2.7.1]
Daud_1965  thiamine pyrophosphate enzyme domain protein TPP-binding [KO:K00170] [EC:1.2.7.1]
Daud_1964  pyruvate/ketoisovalerate oxidoreductase, gamma subunit [KO:K00172] [EC:1.2.7.1]
Daud_1963  4Fe-4S ferredoxin, iron-sulfur binding domain protein [KO:K00171] [EC:1.2.7.1]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00036  Oxaloacetate
C00042  Succinate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00091  Succinyl-CoA
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00311  Isocitrate
C00417  cis-Aconitate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05379  Oxalosuccinate
C05381  3-Carboxy-1-hydroxypropyl-ThPP
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16254  [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
(map 2)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 3)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
KO pathway
ko00020   
LinkDB All DBs

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