KEGG   PATHWAY: daw00020
Entry
daw00020                    Pathway                                
Name
Citrate cycle (TCA cycle) - Candidatus Desulfofervidus auxilii
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011].
Class
Metabolism; Carbohydrate metabolism
Pathway map
daw00020  Citrate cycle (TCA cycle)
daw00020

Module
daw_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:daw00020]
daw_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:daw00020]
Other DBs
GO: 0006099
Organism
Candidatus Desulfofervidus auxilii [GN:daw]
Gene
HS1_001266  ATP-citrate synthase, alpha subunit [KO:K15230] [EC:2.3.3.8]
HS1_001265  ATP-citrate synthase, beta subunit [KO:K15231] [EC:2.3.3.8]
HS1_001268  isocitrate dehydrogenase [KO:K00030] [EC:1.1.1.41]
HS1_000325  pyridine nucleotide-disulfide oxidoreductase [KO:K00382] [EC:1.8.1.4]
HS1_001276  2-oxoglutarate ferredoxin oxidoreductase, subunit A [KO:K00174] [EC:1.2.7.3 1.2.7.11]
HS1_002269  2-oxoacid:acceptor oxidoreductase, subunit A [KO:K00174] [EC:1.2.7.3 1.2.7.11]
HS1_001277  2-oxoglutarate ferredoxin oxidoreductase, subunit B [KO:K00175] [EC:1.2.7.3 1.2.7.11]
HS1_002270  2-oxoacid:acceptor oxidoreductase, subunit B [KO:K00175] [EC:1.2.7.3 1.2.7.11]
HS1_002271  2-oxoacid:acceptor oxidoreductase, subunit C [KO:K00177] [EC:1.2.7.3]
HS1_001275  4Fe-S ferredoxin [KO:K00176] [EC:1.2.7.3]
HS1_002268  (Fe-S)-binding protein [KO:K00176] [EC:1.2.7.3]
HS1_001282  succinyl-CoA synthetase, alpha subunit [KO:K01902] [EC:6.2.1.5]
HS1_001281  succinyl-CoA synthetase, beta subunit [KO:K01903] [EC:6.2.1.5]
HS1_001734  succinate dehydrogenase/fumarate reductase, flavoprotein subunit (subunit A) [KO:K00239] [EC:1.3.5.1]
HS1_001733  succinate dehydrogenase/fumarate reductase, iron-sulfur subunit (subunit B) [KO:K00240] [EC:1.3.5.1]
HS1_001735  succinate dehydrogenase/fumarate reductase, cytochrome b556 subunit (subunit C) [KO:K00241]
HS1_001270  fumarate hydratase, alpha subunit [KO:K01677] [EC:4.2.1.2]
HS1_001271  fumarate hydratase, beta subunit [KO:K01678] [EC:4.2.1.2]
HS1_001269  malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
HS1_002476  pyruvate carboxylase, alpha subunit [KO:K01959] [EC:6.4.1.1]
HS1_002477  pyruvate carboxylase, beta subunit [KO:K01960] [EC:6.4.1.1]
HS1_001566  porA; pyruvate ferredoxin oxidoreductase, alpha subunit [KO:K00169] [EC:1.2.7.1]
HS1_001573  porB; pyruvate ferredoxin oxidoreductase, beta subunit [KO:K00170] [EC:1.2.7.1]
HS1_001571  porC; pyruvate ferredoxin oxidoreductase, gamma subunit [KO:K00189] [EC:1.2.7.7 1.2.7.1]
HS1_001572  porD; pyruvate ferredoxin oxidoreductase, delta subunit [KO:K00171] [EC:1.2.7.1]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00036  Oxaloacetate
C00042  Succinate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00091  Succinyl-CoA
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00311  Isocitrate
C00417  cis-Aconitate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05379  Oxalosuccinate
C05381  3-Carboxy-1-hydroxypropyl-ThPP
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16254  [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
daw00010  Glycolysis / Gluconeogenesis
daw00061  Fatty acid biosynthesis
daw00071  Fatty acid degradation
daw00190  Oxidative phosphorylation
daw00220  Arginine biosynthesis
daw00250  Alanine, aspartate and glutamate metabolism
daw00280  Valine, leucine and isoleucine degradation
daw00350  Tyrosine metabolism
daw00470  D-Amino acid metabolism
daw00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00020   
LinkDB

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