KEGG   PATHWAY: dnm04727
Entry
dnm04727                    Pathway                                
Name
GABAergic synapse - Dasypus novemcinctus (nine-banded armadillo)
Description
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes of receptors: GABAA, GABAB, and GABAC receptors. GABAA and GABAC receptors are ionotropic and mediate fast GABA responses by triggering chloride channel openings, while GABAB receptors are metabotropic and mediate slower GABA responses by activating G-proteins and influencing second messenger systems. GABAA receptors, the major sites for fast inhibitory neurotransmission in the CNS, are regulated by phosphorylation mechanisms, affecting both their functional properties and their cell surface mobility and trafficking. GABA release by the presynaptic terminal is negatively regulated by GABAB autoreceptors, and is cleared from the extracellular space by GABA transporters (GATs) located either on the presynaptic terminal or neighboring glial cells.
Class
Organismal Systems; Nervous system
Pathway map
dnm04727  GABAergic synapse
dnm04727

Other DBs
GO: 0051932
Organism
Dasypus novemcinctus (nine-banded armadillo) [GN:dnm]
Gene
101410636  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101410956  GABRG3; gamma-aminobutyric acid receptor subunit gamma-3 [KO:K05186]
101411559  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101411573  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
101411584  SLC6A12; sodium- and chloride-dependent betaine transporter [KO:K05045]
101411900  GABRQ; gamma-aminobutyric acid receptor subunit theta [KO:K05192]
101412265  GABRA6; gamma-aminobutyric acid receptor subunit alpha-6 [KO:K05175]
101412295  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
101412851  GLUL; glutamine synthetase isoform X2 [KO:K01915] [EC:6.3.1.2]
101412982  SLC6A1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034]
101413194  [KO:K04539]
101413297  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
101413770  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
101413809  [KO:K04345] [EC:2.7.11.11]
101413928  GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
101414190  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
101414215  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
101414315  PLCL1; inactive phospholipase C-like protein 1 [KO:K15375]
101416453  NSF; vesicle-fusing ATPase [KO:K06027] [EC:3.6.4.6]
101417345  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
101418064  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 [KO:K04615]
101418484  [KO:K04851]
101418542  GABRA4; LOW QUALITY PROTEIN: gamma-aminobutyric acid receptor subunit alpha-4 [KO:K05175]
101418700  SLC38A2; sodium-coupled neutral amino acid transporter 2 [KO:K14207]
101419332  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
101419491  GAD1; glutamate decarboxylase 1 isoform X1 [KO:K01580] [EC:4.1.1.15]
101419849  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101420020  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
101420027  SLC6A11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044]
101420374  GPHN; gephyrin [KO:K15376] [EC:2.10.1.1 2.7.7.75]
101420741  [KO:K04536]
101421427  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
101421680  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101422732  [KO:K08048] [EC:4.6.1.1]
101423121  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
101423562  GABRD; gamma-aminobutyric acid receptor subunit delta [KO:K05184]
101423692  PRKACB; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
101424155  GABRA2; gamma-aminobutyric acid receptor subunit alpha-2 isoform X1 [KO:K05175]
101424427  [KO:K04344]
101424515  [KO:K01580] [EC:4.1.1.15]
101424600  GABRG1; gamma-aminobutyric acid receptor subunit gamma-1 isoform X2 [KO:K05186]
101424635  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
101426457  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
101426538  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101426647  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
101427206  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101427667  SLC38A3; sodium-coupled neutral amino acid transporter 3 [KO:K13576]
101427927  ADCY7; LOW QUALITY PROTEIN: adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
101427975  GABRP; gamma-aminobutyric acid receptor subunit pi [KO:K05189]
101428860  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
101429307  ABAT; 4-aminobutyrate aminotransferase, mitochondrial [KO:K13524] [EC:2.6.1.19 2.6.1.22]
101430279  SLC32A1; vesicular inhibitory amino acid transporter [KO:K15015]
101430492  TRAK2; trafficking kinesin-binding protein 2 isoform X1 [KO:K15374]
101431251  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
101431301  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X9 [KO:K04850]
101431326  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
101432359  [KO:K01425] [EC:3.5.1.2]
101434356  GLS2; glutaminase liver isoform, mitochondrial [KO:K01425] [EC:3.5.1.2]
101434417  SLC38A5; sodium-coupled neutral amino acid transporter 5 [KO:K14992]
101436660  GAD2; glutamate decarboxylase 2 [KO:K01580] [EC:4.1.1.15]
101439659  SLC12A5; solute carrier family 12 member 5 isoform X1 [KO:K23967]
101440883  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
101441349  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
101441830  [KO:K01425] [EC:3.5.1.2]
101442415  [KO:K05190]
101442901  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101442950  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
101442978  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
101444486  GABRG2; gamma-aminobutyric acid receptor subunit gamma-2 isoform X1 [KO:K05186]
101444674  SLC38A1; sodium-coupled neutral amino acid transporter 1 [KO:K14990]
101444811  GABRB1; gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181]
101445239  GABRA1; gamma-aminobutyric acid receptor subunit alpha-1 [KO:K05175]
101445596  [KO:K04345] [EC:2.7.11.11]
101445685  GABRB2; gamma-aminobutyric acid receptor subunit beta-2 [KO:K05181]
101445686  GABRA5; gamma-aminobutyric acid receptor subunit alpha-5 [KO:K05175]
101446475  GABRR1; gamma-aminobutyric acid receptor subunit rho-1 [KO:K05190]
101446505  SLC6A13; sodium- and chloride-dependent GABA transporter 2 isoform X1 [KO:K05046]
101446603  GABRB3; gamma-aminobutyric acid receptor subunit beta-3 [KO:K05181]
101447107  GABRA3; gamma-aminobutyric acid receptor subunit alpha-3 isoform X2 [KO:K05175]
101447207  GABRR2; gamma-aminobutyric acid receptor subunit rho-2 [KO:K05190]
101447351  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
101447543  GABRE; LOW QUALITY PROTEIN: gamma-aminobutyric acid receptor subunit epsilon [KO:K05185]
101447838  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101447951  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X2 [KO:K04630]
111760787  [KO:K07826]
111763551  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
111764136  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
111764630  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
Compound
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00042  Succinate
C00064  L-Glutamine
C00076  Calcium cation
C00238  Potassium cation
C00334  4-Aminobutanoate
C00575  3',5'-Cyclic AMP
C00698  Cl-
Reference
  Authors
Davis KL, Charney D, Coyle JT, Nemeroff C (ed).
  Title
Neuropsychopharmacology: The fifth generation of progress
  Journal
Lippincott Williams & Wikins (2002)
DOI:10.1002/hup.431
Reference
PMID:17499109
  Authors
Farrant M, Kaila K
  Title
The cellular, molecular and ionic basis of GABA(A) receptor signalling.
  Journal
Prog Brain Res 160:59-87 (2007)
DOI:10.1016/S0079-6123(06)60005-8
Reference
PMID:9364667
  Authors
Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL
  Title
GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'.
  Journal
Trends Neurosci 20:523-9 (1997)
DOI:10.1016/S0166-2236(97)01147-8
Reference
PMID:20655485
  Authors
Pinard A, Seddik R, Bettler B
  Title
GABAB receptors: physiological functions and mechanisms of diversity.
  Journal
Adv Pharmacol 58:231-55 (2010)
DOI:10.1016/S1054-3589(10)58010-4
Reference
PMID:21376567
  Authors
Chalifoux JR, Carter AG
  Title
GABAB receptor modulation of synaptic function.
  Journal
Curr Opin Neurobiol 21:339-44 (2011)
DOI:10.1016/j.conb.2011.02.004
Reference
PMID:20655481
  Authors
Padgett CL, Slesinger PA
  Title
GABAB receptor coupling to G-proteins and ion channels.
  Journal
Adv Pharmacol 58:123-47 (2010)
DOI:10.1016/S1054-3589(10)58006-2
Reference
PMID:17499108
  Authors
Emson PC
  Title
GABA(B) receptors: structure and function.
  Journal
Prog Brain Res 160:43-57 (2007)
DOI:10.1016/S0079-6123(06)60004-6
Reference
PMID:16932937
  Authors
Kornau HC
  Title
GABA(B) receptors and synaptic modulation.
  Journal
Cell Tissue Res 326:517-33 (2006)
DOI:10.1007/s00441-006-0264-7
Reference
PMID:18382465
  Authors
Jacob TC, Moss SJ, Jurd R
  Title
GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.
  Journal
Nat Rev Neurosci 9:331-43 (2008)
DOI:10.1038/nrn2370
Reference
PMID:12086709
  Authors
Kneussel M
  Title
Dynamic regulation of GABA(A) receptors at synaptic sites.
  Journal
Brain Res Brain Res Rev 39:74-83 (2002)
DOI:10.1016/S0165-0173(02)00159-5
Reference
PMID:21555068
  Authors
Luscher B, Fuchs T, Kilpatrick CL
  Title
GABAA receptor trafficking-mediated plasticity of inhibitory synapses.
  Journal
Neuron 70:385-409 (2011)
DOI:10.1016/j.neuron.2011.03.024
Reference
PMID:19374920
  Authors
Arancibia-Carcamo IL, Kittler JT
  Title
Regulation of GABA(A) receptor membrane trafficking and synaptic localization.
  Journal
Pharmacol Ther 123:17-31 (2009)
DOI:10.1016/j.pharmthera.2009.03.012
Reference
PMID:16787421
  Authors
Bak LK, Schousboe A, Waagepetersen HS
  Title
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
  Journal
J Neurochem 98:641-53 (2006)
DOI:10.1111/j.1471-4159.2006.03913.x
Reference
PMID:15210304
  Authors
Conti F, Minelli A, Melone M
  Title
GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.
  Journal
Brain Res Brain Res Rev 45:196-212 (2004)
DOI:10.1016/j.brainresrev.2004.03.003
Reference
PMID:12888801
  Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
  Title
GABAergic dysfunction in mood disorders.
  Journal
Mol Psychiatry 8:721-37, 715 (2003)
DOI:10.1038/sj.mp.4001362
Reference
PMID:10780899
  Authors
Chebib M, Johnston GA
  Title
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
  Journal
J Med Chem 43:1427-47 (2000)
DOI:10.1021/jm9904349
Related
pathway
dnm00020  Citrate cycle (TCA cycle)
dnm00250  Alanine, aspartate and glutamate metabolism
dnm04144  Endocytosis
dnm04721  Synaptic vesicle cycle
KO pathway
ko04727   

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