Dipodomys ordii (Ord's kangaroo rat): 105984201 Help Entry 105984201         CDS       T07834                                  Symbol Ryr3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism dord  Dipodomys ordii (Ord's kangaroo rat) Pathway dord04020   Calcium signaling pathway dord04371   Apelin signaling pathway dord04713   Circadian entrainment dord04921   Oxytocin signaling pathway dord04970   Salivary secretion dord05010   Alzheimer disease dord05012   Parkinson disease dord05020   Prion disease dord05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:dord00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     105984201 (Ryr3)    04020 Calcium signaling pathway     105984201 (Ryr3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     105984201 (Ryr3)   09154 Digestive system    04970 Salivary secretion     105984201 (Ryr3)   09159 Environmental adaptation    04713 Circadian entrainment     105984201 (Ryr3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     105984201 (Ryr3)    05012 Parkinson disease     105984201 (Ryr3)    05020 Prion disease     105984201 (Ryr3)    05022 Pathways of neurodegeneration - multiple diseases     105984201 (Ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:dord04040]     105984201 (Ryr3) Ion channels [BR:dord04040]  Voltage-gated cation channels   Ryanodine receptor    105984201 (Ryr3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_5 EF-hand_8 Motif Other DBs NCBI-GeneID:  105984201 NCBI-ProteinID:  XP_012869761 Ensembl:  ENSDORG00000015668 UniProt:  A0A1S3EZB7 LinkDB All DBs Position Unknown AA seq 4827 aa AA seqDB search MSLHFSLQDPEEPSKVEVVRFRSAFFSGECDKDQDDEVVLQCIANIHKEQRKFCLAAEGL GNRLCFLEPTSEAKYIPPDLCVCSFVLEQSLSVRALQEMLASTGEDGGEGAAQGGGHRTL LYGHAILLRHSFSGMNTATNPRGLHAGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSS ERYLHLSISNGSIQVDASFMQTLWNVHPTCSGSGVEEGYLLGGHVVRLFHGRDECLTIPS TDQNDAQHRRLFYEAGGAGMRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALT EDQGLLLQDRGKADTKSTAFCFRASKEIKEKLDSSHKRDMEGMGIPEIKYGDSVCFVQHV ASGLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESRAARIIRNTTALF SQCLSGNNRTAAAAIALPVEEVLQTLQDLIAYFEPPEEGLRHEEKQNKLRSLKNRQNLFK EEGMLALVLNCIDRLNVYNSVAHFAGLAREESSLAWKEVLNLLYKLLAALIRGNRNNCAQ FSTNLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIKSIISLLDKHGRNHKV LDVLCSLCLCNGVAMRANQNLICDNLLPQRNLLLQTRLINDVTSIRPNIFLGVAEGSAQY KKWYFELIIDQVDPFLTAEPTHLRVGWASSPGYAPYPGGGEGWGGNGVGDDLHSYGFDGL HLWSGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFP VMSFSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKERLRLEAVKEYKRDTGGVRDL LGTTQLLSHASFTPCPVDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDD NKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEELKKVKLPKNF MMSNGYKPAPLDLSDVKLLPPQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNP RLVPYALLDERTKKSNRDSLREAVRTFVGYGYNVEPSDQELADPAVEKVSIDKLRFFRVE RSYAVRSGKWYFEFEVVTGGAMRVGWARPGCRPDVELGADDQAFVFEGSKGQRWHQGSGY FGRTWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYDIENGFVPICSLGLSQ IGRMNLGTDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVV RIDSTMDSPPCLKVTHKTFGTQNSNANMIYCRLSMPVECHSFSHSSCLDSDVFQKRKQMH EILSPTTTQCHYAVRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRV RESVKRSNCYMVWGGDVVASSQRPTRSNVDLEISCLVDLAMGMLSFSANGKELSTCYQVE PNTKVFPAVFLQPTSTALFQFELGKLKNAMPLSAAIFKSEEKNPIPQCPPRLDVQTMQPV LWSRMPSSFLKVETERVSERHGWAVQCLEPLQMMALYIPEENRCVDILELCEQEDLMQFH YHTLRLYSAVCALGNSRVACALCSHVDLPQLFYAIDSKYLPGLLRSGFYDLLISIHLANA KERKLMMKNEYIIPITRATRDIRLYPDQSKRPGLPGVGLRACLKPGCRFTTPSAVATREE PQKQSPEIPLELLKTKALGMLTEAVHSSGAHIRDPVGGSVEFQFVPVLKLIGTLLIMGVF DDDDVRRILLLIDPSVFGERAGETEEGTEKEEATQVEEKAVEAGEKAGKKAPARGLLQTR MPESVKLQVNMLLNFQLGENCPCPEDIREELYDFHGDLLLHCGVPVEEEEEEEEDSSWPG RLRALVYKIKGPPRPEKMKRAEEEERYPATLRELVSQTMICWAQENQIQDAELVRVMFDL LRRQYDSTGELLRALRKTYTISQASVSDTGQLLAALGQIRSLLSVRMGKEEEQLMIHGLG DIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQITFPKMVASCCRFLCYFCRISR QNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLEKVVTY LAGCGLQSCPLLLAKGYPDIGWNPIEGERYLTFLRFAVFVNSESVEENASVVVKLLIRRP ECFGPALRGEGGNGLLAAMQGAIKISESPALDLPAQGYKRDASEGDGEEDAVVHMGNAVM SFYSALIDLLGRCAPEMHLIQAGKGEAIRIRSILRSLVPTEDLVGIVSIPLKLPSLNKDG SVSEPDMAANFCPDHKAPMVLFLDRVYGVEDQAFLLHLLEVGFLPDLRASASLDTVSLST TEAALALNRYMCSAVLPLLTRCAPLFAGTEHHTSLIDSTLQTIYRLSKGRSLTKAQRDTI EECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTSHYEQCWKYYCLPAGWGG HGMAVEEELHLTEKLFWGIFDSLSRKKYDPDLFLMALPCLSAIAGALPPDYLDTRITAVL EKQVSVDADGNFDPKPINTMNFSLPEKLESIVTKYAEHSHDKWACDKSQSGWKYGISLDE NVKTHPLMRPFKTLTEKEKEIYRRPARESLKTMLAVGWAVERTREGEASVQQRENEKLRS ALQTSQGSSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKSELESKGGGSHPLL VPYDTLTAKEKFRDREKAQDLFKFLQVNGIIVSRGAKDTELDASSMEKRFAYKFLKKILK YVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKRALCGPQHGRRLKAEAEGEVGWARG AASGDPAAFQMPRKHTLRRADAAFQHRIPRKPCWAPGATVCGLFCKLAALVRHRISLFGS DASTMVSCLHILAQTLDTRTVVKSGSEPVKAGLRAFFENAAEDLERTSENLKLGKFTHSR TQIKGVSQNINYTTVALLPILTSIFEHVAQHQFGVDLLLSDVQISCYRILCSLYSLGTGR NIYVERQRPALGECLASLAAAVPVAFLEPTLNRYNPLSVFNTKTPRERSILGLPDMVEDM CPGVPPLEGLMKEIGSLAESGARYSEMPHVIEVTLPMLCSYLSYWWAHGPEGLPPSAGPC CTTVTSEHLSLILGNILKIINNNLGIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLE KLKKKAVKTVQEEEQLRADGKADTQEAELLILDEFSILCRDLYAFYPLLIRYVDNHRSNW LKSPDADSDQLFRMVAEVFILWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAME VKSGGQDQERKKTKRRGDLYSIQTSLIVATLKKMLPVGLNMCTPGDQELISLAKSRYGCR DTDEEVKEHLRNNLHLQEKSDDPAVKWQLNLYKDVIRSDEPSDPEKTVERVQRISAAVFH LEQVEQPLRSRKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETE AYSFEEKLVQDLARSPTVEEEEEEEPERQPDPLHQIILHFSRSALTERSKLEEDPLYTSY SSMMAKSCQSGEDEDEEEDKEKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGE MSPMVVETLKLGIAILNGGNTGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFER QNKAEGLGMVTEEGTLIVRERGEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGN TTTVNIIISTVDYLLRLQESISDFYWYYSGKNVIDESGQHNFSKALAVTKQIFNSLTEYI QGPCVGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLS LLEGNVVNGTIGKQMVDTLVESSTNVEMILKFFDMFLKLKDLTGSDAFKEYDPDGKGIIS KREFQKAMEGQKQYAQSEIDFLLSCAEADENDLFNYVDFVDRFHEPAKDIGFNVAVLLTN LSEHMPNDPRLKCLLDPAESVLKYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQ VKESKRQFIFDVVNEGGEQEKMELFVSFCEDTIFEMQLASQISESDSADRPEEEEEGEEE ESSCALGTEGQEEEDGSLECASAFAVACAAAKRSAAALLRRATLRNLRRQCRSVRKMAAR ELAQACLGLASALCLGLLRGLLALLAGLAQALWSTVFGGGLVEGARNIRVTKILGDMPDP TQFGIHDDATEAERADAGELRAAAEPGHAVKGGKGDADLMPDLFGLHPNKEGPAVGLGDL SEVIGKAEPPTLESTVRRKRKAQVAAAARAAQAADLNAESEKADMEDREKEDEAKEEGQA EVLWTAVTKRKPHRRGQKAEKPEAFMANFLKGLDTYQTKLLHYLARNFYNLRLLALFVAF AINFILLFYKVTEEPLEETEDVANLWNSFNEEDEEEAVVFFVLQESTGYMAPALGALAVV HTVISLVCVVGYYCLKVPLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVVNTP SFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKNALDFSPVEETTAEAASLVSWLSS IDMKYHIWKLGVVFTDNSFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSV THNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVG VRAGGGIGDEIEDPAGDPYEMYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQV REDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYV WKMYQERCWDFFPAGDCFRKQYEDQLA NT seq 14484 nt NT seq  +upstreamnt  +downstreamnt atgtccctgcatttctccctgcaagatccagaggaaccaagtaaggtggaggtggtcaga ttccgatcggccttcttcagtggggaatgtgacaaagatcaagatgacgaggtggtactc cagtgcatcgcaaacatccacaaggagcagaggaagttctgcctggcagccgagggactc gggaaccgcctgtgcttcttggaacccacctctgaggccaagtacattccgccagatctc tgcgtctgcagtttcgtgctggagcagtccctgtccgtcagagccctgcaggagatgcta gccagcaccggggaagatggcggcgaaggggcagcacaagggggcggccacaggaccctg ctctatggccacgcaatcctcctgcggcactccttcagtggcatgaacacagcgactaat ccaaggggccttcatgcaggagaagcctgttggtggaccattcaccctgcttccaaacag aggtccgagggggagaaagtccggattggtgatgacctcatccttgtcagtgtgtcctct gaaagataccttcatctctccatctcgaacggcagcattcaagtggatgcctcctttatg caaacgctctggaacgtacatcccacctgctcgggaagcggtgtggaagaagggtatctc cttggcggccatgttgtgcggctcttccacggtcgtgatgagtgtctgacaataccgtct acagaccaaaacgacgcccagcataggaggttgttctatgaagctgggggcgccgggatg agagccaggtctctgtggagagtggagccccttcggataagctggagtggcagcaacatc cgctggggccaggccttccggctccggcatctcaccacaggccactacttggccttgacc gaggaccaagggcttctgctgcaggaccgggggaaggccgacaccaagtccacagccttc tgcttccgggcatccaaggagatcaaggagaaactggattccagtcacaagcgcgatatg gaaggcatggggattccagaaatcaagtacggggattctgtctgctttgtccagcatgtg gctagtggcctgtgggtcacctacaaagcacaagacgccaaaacctcccgcctaggacct ctgaagagaaaggttatcctccaccaggaaggccacatggacgacgggctgacgctgcag agatgccagcgtgaggagtcccgggctgcccggatcatccggaacacaacggccttattc agccagtgtctcagtggaaataaccgcacggccgccgccgccatcgccctgccggtagag gaggtcctgcagaccttacaggacttgattgcctacttcgagcctccggaggaggggctt cggcacgaagagaagcagaacaagcttcgctccctcaaaaacagacagaacctcttcaaa gaagagggaatgttggccctcgtgttgaattgcatcgaccgcttgaatgtctacaacagc gtggcacactttgcaggactcgcaagggaagagagcagcctggcttggaaagaagtgcta aacctcctgtacaagctgctagccgctctcattcgtgggaacagaaacaactgtgcacag ttctccaccaacctcgactggctcatcagcaaactggacaggctggaatcttcctcaggt atcttggaggtcttgcactgcattttgatcgaaagcccggaagccttaaatctgatagct gaaggacacatcaagtccatcatctccctgttggataaacatggtcggaaccacaaggtt ctggatgtcctgtgctccctctgtctctgcaacggggttgccatgagagccaaccagaac ctgatctgtgacaacttactgccccagagaaacctgctcctgcagacgcggctgatcaat gacgtgaccagtatccggccaaacatcttcctgggagttgctgagggctcagcccagtat aagaagtggtactttgagctgattatcgaccaggtggaccccttcctgacagcggagccc acgcacctgcgggtgggctgggcatcgtccccgggctacgccccgtaccccggaggcggg gaaggatggggaggtaatggtgtgggcgatgacttgcactcctacggcttcgacggactt cacctttggtcaggacggatacccagagcggtcgcctccatcaaccagcacctgctgagg tcggacgacgtggtgagctgctgcctggacctgggggtgcccagcatctccttccgcatc aacgggcagccggtccagggcatgtttgagaacttcaacaccgacgggctcttcttccct gtgatgagcttctcagccggcgtcaaagtacgtttcctgatgggtggacgccatggggaa tttaagtttctgcctccctctgggtatgccccgtgctatgaagccttgctcccgaaagag aggctgagactggaggccgtgaaggaatacaagcgcgatacgggcggcgtccgtgacctc ctgggcaccacccagctcctctcccacgcctccttcaccccgtgtccggtcgacaccagt caggttgttttaccacctcacctggagaagatccgagacagactggccgaaaacatccac gagctttggggaatgaacaaaatagaactcggctggactttcggcaaaatacgggatgac aataaaagacagcacccctgccttgtggagttttcaaagcttcctgaaactgagaagaat tacaacctacagatgtcgactgaaaccttaaaaaccctcctggccctgggctgccacatt gctcacgttaaccctgccgcggaggaggagctcaagaaggtcaaactgcccaaaaacttc atgatgtctaacggctacaaaccagcccctttggatttgtctgatgtgaagctcttacct cctcaagaagttttagtggataagcttgcagaaaacgcacataatgtttgggcaaaggac agaattaaacaagggtggacctatggcattcagcaggatttgaagaacaaaagaaacccc cgtctggtgccatatgctctactggacgaacgcactaagaagtcaaaccgggacagcctt cgtgaagccgttcggacatttgtgggctatgggtataacgtggagccttcagaccaagaa ctagctgatccggctgtagaaaaagtcagcatagacaagctccgatttttccgggtggag cggtcctacgcggtccggtctgggaagtggtactttgagtttgaagtggtgaccggaggc gccatgcgcgtcggctgggcccggccgggctgccgccccgacgtcgagctgggggctgac gatcaagcatttgtgtttgaaggcagcaagggccagcgctggcaccaagggagtgggtat tttgggcgaacatggcagcccggcgacgtggttggatgtatgattaacctggacgatgcc tcaatgatcttcacactgaatggggagctgctgatcaccaacaaaggctctgaacttgcc tttgctgactatgacattgagaacggctttgtgcccatctgctccctggggctgtctcag attggccgcatgaacctggggacagatgccagcaccttcaagttttacaccatgtgtggc ctccaggagggctttgagccttttgccgtcaacatgaaccgggatgtggcgatgtggttc agcaagcgccttcccacgtttgtcaacgtaccgaaggaccacccccacatagaggtcgtg aggattgatagcaccatggacagccctccatgtctcaaggtgacccacaagacatttggc actcagaacagcaatgccaacatgatctactgccgcctgagcatgcctgttgagtgccat tccttcagccacagctcctgtctggacagcgatgttttccagaaaaggaaacagatgcat gaaatactctctcctacaacaacacaatgccactatgccgtccgcatctttgctgggcag gatccttcctgtgtctgggttggatgggtgactccagactatcatttgtacagtgaaaag tttgacctgaataaaaactgcacggtgactgtaaccctgggagatgaaagaggccgggtc cgcgaaagtgtgaaacgcagcaactgctacatggtctggggcggggacgtagtagccagc tcccagagacccactcggagcaatgtggacctggagatcagctgccttgtggacctggcg atgggcatgctgtccttctcggctaacggaaaggagctcagcacctgctaccaggtggag cccaacacaaaagtgtttccagccgtcttcctgcagccgacaagcactgctttgtttcag tttgaacttgggaagctgaagaatgccatgcccttgtcggcagccatatttaagagtgag gagaagaaccccatcccgcagtgcccgccgcggctggacgtgcagaccatgcagcctgtg ctctggagccgcatgcccagcagcttcctgaaggtggagacggagcgggtgagcgagcgc catggctgggccgtgcagtgcctggagcccctgcagatgatggcgctgtacatccccgag gagaacaggtgcgtggacatcctggagctctgcgagcaggaggacctgatgcagttccac taccacacgctgcggctgtacagcgccgtgtgcgccctggggaacagccgggtggcctgt gcgctgtgcagccacgtcgacctgccccagctcttctacgccatcgacagcaagtacctc cccggcctgcttcggtccggtttctatgacctgctcatcagcatccacctggccaatgcc aaggagaggaagctgatgatgaagaatgagtacatcatccccatcacccgcgccaccagg gacatccgcctttacccggaccagtccaagcggcccgggctgcccggggtggggctgcgg gcctgcctcaagccaggctgccggttcaccacccccagcgccgtggccaccagggaggag ccgcagaagcagagccctgagatccccctggagctgctcaagacaaaggcgctgggcatg ctgacggaggctgtgcacagcagcggggcccacatccgggaccccgtcgggggctccgtg gagttccagttcgtgcccgtgctgaagctcattggaaccctgctgatcatgggtgtgttt gatgacgacgatgtgcgccggatcctcctcctgatcgacccctctgtgtttggggagcga gcgggggagacggaagagggcacggagaaggaggaggccacgcaggtggaggagaaggcg gtggaggctggggaaaaggctggcaagaaggctcctgccagaggcctgctgcagacccgg atgcctgagtccgtcaagctgcaggtcaacatgcttctcaacttccagctgggggagaat tgcccatgcccggaggacatccgtgaggagctgtatgacttccacggggacctgctcctc cactgtggtgtccccgtggaggaggaggaggaggaggaggaggacagctcctggccagga agactgcgtgccttggtgtacaaaatcaaaggcccgcccaggcctgagaagatgaagcgg gcagaggaggaggagcgataccccgccacgctgagggagctggtctcccagaccatgatc tgctgggcccaggagaaccagatccaggacgcggagctggtccgcgtgatgttcgacctc ctccggaggcagtacgacagcaccggggagctgctgcgggccctgcgcaagacctacacc atcagccaggcctccgtgagcgacaccggccagctgctggccgccctgggccagattcgc tccctcctcagcgtccggatgggcaaggaagaggagcagctcatgatccacgggctggga gacatcatgaacaacaaggtgttttaccagcatcccaacctcatgcgagtcctgggcatg cacgagaccgtgatggaggtgatggtgaacgtgttgggaaccgagaagtcgcagatcact ttcccaaagatggttgccagctgctgccgcttcctctgctatttctgtcgaattagccgg caaaatcagaaggccatgttcgagcatctaagttacctgctagagaacagcagtgtggga ctagcctccccctccatgagggggtccacgcccctggacgtggcagcctcctccgtgatg gacaacaacgagttagcgctgggcttagaggagccggatctggaaaaggtggtaacctac ctggcgggctgtggcctgcagagctgccccctgcttctggccaaagggtaccccgacatc ggctggaaccccatcgaaggggagcgctacctgaccttcctgaggtttgccgtcttcgtg aacagtgaaagcgtggaggagaatgccagcgtggtggtcaagctgctcatcagacggcca gagtgcttcgggccagcgctgcggggcgaggggggcaacgggctgctggcggccatgcag ggcgccattaagatctccgagagcccggctctggacctccccgcccaggggtacaagaga gacgcctcagagggcgatggagaggaggacgcggtcgtgcacatgggcaatgcggtcatg tcattctattctgcactcatcgatctcctgggccgctgtgctcccgagatgcacctcatc caggcaggaaaaggggaagccatccgaatccggtccatcctgcgctccctggtccccaca gaagacctggtcgggattgtcagcattcccctgaagctcccctctctgaacaaagacggg tcggtcagcgaaccagacatggcagccaacttctgccccgaccacaaggcacccatggtg ctgttcctggaccgtgtgtatggggttgaggaccaagctttcctgctgcatctgctggag gttggctttttacctgacctgagagcctctgcctctctagatacagtgtccctcagcacc acggaggccgcgctggccctgaacaggtacatgtgctccgcggtgctcccgctcctcacg aggtgtgctcctctctttgccgggacggagcatcacacctccctcatcgattccacgctg cagacaatatacaggctttccaagggacggtctctcaccaaagcccagagggacaccata gaagaatgcttgctcgccatttgcaatcatttgaggccctccatgctgcagcagctcctg agacgcctggtcttcgatgtgccacagctcaatgagtactgcaaaatgcctctaaagctt ctgacaagccactatgagcagtgctggaagtattactgcctccctgcgggatggggcggc cacgggatggctgtggaagaggagctgcacctcacggaaaagctcttctgggggatcttt gactccctctcccgcaagaagtacgacccggaccttttcctcatggcccttccctgtctc agcgccattgccggggctctgccgccagattatctggacacgcgaatcacagccgtgttg gagaaacaggtctcggtggatgctgatggcaactttgacccgaagcccatcaacaccatg aatttttctttgcctgaaaaattggaatccatcgtcaccaagtatgctgaacactcacat gacaaatgggcctgtgacaagagtcagagtggatggaaatacggcatttccctagatgaa aatgtgaagacccaccctctgatgagacccttcaagacgctgactgagaaggagaaggag atttaccgccggcctgccagagagtccctaaagaccatgctggcggtgggctgggctgtg gagaggaccagagagggggaggcttcggttcaacaacgggaaaatgagaaactccgaagc gctctgcagaccagccagggtagcagctacagccctgcgcctctggatctctccaacgtg gtgctctccagggagctgcagggaatggtggaggtggtggccgagaactatcacaatatc tgggccaagaagaagaagtcagagctggagagcaaaggtgggggcagccacccccttttg gtaccgtatgacaccttgacagccaaggaaaagttcagggaccgagagaaggcgcaggac ctgttcaagttcctccaagtgaatggcattatagtttccaggggggcgaaggacacggag ctggatgcctcctccatggaaaagagatttgcctacaagtttctgaagaaaattctgaag tatgttgactctgctcaggagttcatcgcccacttggaagccatcgtgagcagtgggaaa actgaaaagtctccccatgaccaggagatcaaattctttgccaagagggcgctgtgcggg ccacagcatgggcgccggctgaaggccgaggcggagggtgaggtgggctgggcccgaggg gcggcctccggggaccccgcagctttccagatgccccggaagcatactctgcggcgggca gatgctgccttccagcaccgcatccccagaaagccttgctgggcaccaggggcgacggtg tgcggcctcttctgcaaacttgctgctcttgttagacacaggatttccctctttggaagc gacgcttctacaatggtcagctgtctccacatcttagcgcagacacttgacacaaggact gtggtgaagtctggctcagagcccgtgaaggctggcttgcgggccttctttgagaatgcc gccgaggacttagagaggacttcggaaaacctgaagctggggaagttcacccactccaga acccagatcaaaggcgtctctcagaacattaactacaccacggtggccctgctacccatc ctgacgtccatctttgagcacgtggcccagcaccagttcggggtggatctgctcttgagc gacgtgcagatttcatgctaccgcatactgtgtagcctctattccctcggcaccggaagg aacatctacgttgaaaggcaacgtcctgcccttggagaatgtctggcttccctggcagcc gcagtgcctgtggccttcctggagcccaccctgaatcgctacaatcccctctcggtcttc aacaccaaaactcccagggagaggtctattctggggctgccagacatggtggaagacatg tgtcccggcgtccccccgctggaaggcctgatgaaggagatcggcagcctggccgagtcg ggcgcccggtactcagagatgccccacgtcatcgaggtgaccctgcccatgctgtgcagc tacctgtcctactggtgggcgcacggccccgagggcctgcccccgagcgccgggccctgc tgcaccaccgtcacgtctgagcacctcagcctcatcctgggcaacatcctgaaaatcatc aacaacaacctgggcatcgacgaggcttcctggatgaagcgcattgcagtgtacgcccag ccgatcatcagcaaagccaggccggacctgctccgcagccacttcatccccaccctggag aagctgaagaagaaggccgtgaagacggtgcaggaggaggagcagctgcgagccgacggc aaggcggacacgcaggaggccgagctgctcatcctggacgagttctccatcctctgcaga gacctctacgccttctacccgctgctgatccgctacgtggacaaccacaggtctaactgg ctgaaaagccctgatgctgactcggatcagcttttccgcatggtggcagaggtcttcatc ctgtggtgcaaatctcataacttcaagagagaagagcaaaattttgtgattcagaatgaa attaataatttggcatttttgactggagacagcaaaagcaagatgtccaaagccatggaa gtcaagtctggaggacaggaccaggagcggaagaagacgaagcggaggggagacctgtac tccatccagacctccctcatcgtggccaccctgaagaagatgctgcccgtgggcttgaac atgtgtactccgggcgaccaggagctgatctccctggcgaagtcccgatacggctgtagg gacacggatgaggaggtcaaggagcatctgcgcaacaacctgcatttgcaagagaagtcc gacgatccagctgtaaaatggcagctaaacctctacaaggatgtgatcaggagtgacgag ccttcggatcctgaaaagacggtggagcgcgtccagaggatctcagccgccgtcttccac ctggagcaggtggagcagcctttgaggtcccggaaggccgtctggcacaagctgctgtcc aagcaacggaagcgggctgtggtggcctgcttcaggatggccccgctctacaacctgccc aggcaccgctctattaacctcttcctccatggctatcagagattttggatagaaacagag gcgtattcctttgaagagaagctagtgcaggacttggctagatcgcccacggtggaagag gaagaggaggaagagccggaaaggcagccggacccgctgcaccagatcattctccacttc agccgcagcgcgctcacagagaggagcaaactggaagaggaccctttgtatacctcctac tccagcatgatggccaagagctgtcagagcggagaggatgaagacgaagaggaagacaag gaaaaaacatttgaggagaaagagatggagaaacagaaaaccctctatcaacaggctcgg ctgcatgaacgtggggctgccgagatggttctacagatgatcagtgccagcaaaggtgag atgagccctatggtggtggagacgctgaagctggggatcgccattctcaacggcggcaac acgggcgtgcagcagaaaatgctagattatctaaaggagaaaaaagatgctggattcttt cagagcctttctggtcttatgcagtcctgcagcgtccttgatttgaatgcatttgagaga cagaacaaagccgaaggcctggggatggttacggaagaaggaacacttattgttcgtgaa cgtggtgaaaaggttcttcagaatgatgagtttacacgagacctctttagattcctgcag ttgctttgtgaaggccacaacagcgactttcagaacttcctgcggactcagatggggaac accaccactgtaaacatcatcatcagcactgtggactaccttctgcgtctgcaggaatca atcagtgatttctactggtactactcagggaagaacgtcattgatgaatcagggcagcac aatttttctaaagctctggcggtcaccaagcagattttcaattctcttacggaatacatc cagggtccgtgtgtggggaaccagcagagcctggcccacagccggctgtgggacgccgtg gtgggcttcctccacgtgttcgccaacatgcagatgaagctctctcaggattccagtcag atcgagctgctgaaggaactcttggatctccttcaggacatggtggtgatgcttctgtcc ctcctggaagggaatgtggtaaatggaaccatcggcaagcagatggttgacaccctggta gaatcatctaccaacgtagaaatgatcctgaaattctttgacatgttcttgaaacttaag gacttaaccggctccgacgccttcaaagaatacgacccagatgggaaagggattatctcc aaaagagaattccagaaggccatggaagggcagaagcagtacgcacagtccgagattgac tttctcctctcctgtgccgaagcggatgagaatgacctgtttaactacgttgactttgtg gaccggttccatgagccggccaaggacatagggttcaacgtggcagtgctgttgaccaat ctgtctgaacacatgcccaatgaccctcgcctcaagtgcttgctcgaccccgcggaaagt gtgctgaaatacttcgagccctacctggggcgcatcgagatcatgggaggggccaagaaa atcgagcgcgtgtatttcgagatcagcgagtccagccggactcagtgggaaaagcctcaa gtgaaggaatccaagcggcagttcatctttgacgtcgtcaacgaagggggggagcaagaa aagatggagctgtttgtgagcttctgtgaggacaccatctttgagatgcagctggcctct cagatctctgagtccgactcagccgacaggccggaagaggaggaggagggggaagaggaa gagtcttcctgtgcgttaggcacggagggtcaggaggaggaggacgggtccctggagtgt gcctcggcgtttgccgtggcctgtgccgcggccaagagaagcgcggccgccctgctgagg agggccaccctgaggaacctgcggaggcagtgccggagcgtgaggaagatggcggcccgg gagctggcgcaggcctgcctgggcctggcctccgcgctgtgcctggggctgctccgcggg ctcctcgccctcctggcgggcctcgctcaggccctctggagcacggtgttcggagggggc ctggtggaaggcgcgaggaacatccgagtgaccaagatcctgggagacatgcccgacccg acccagtttggcatccatgacgacgccaccgaggccgagcgggccgacgcgggcgagctg cgtgccgccgccgagccgggccacgcggtgaagggcgggaagggggacgcagacctcatg ccagacctctttggactccacccaaacaaagaagggcccgcagtgggcttaggtgacctg tctgaagtcatcggcaaggccgagccgcctacgctggagagcaccgtgcggaggaagagg aaagcccaggtggcggcggcggcgagagcggcacaggcggcagaccttaatgcggagtct gagaaggcggacatggaagaccgagaaaaggaggacgaagccaaagaggagggccaggct gaggtcctgtggacagccgtcaccaagaggaagccgcaccggcggggccagaaggccgag aagcctgaggccttcatggccaacttccttaaaggcctggacacctaccagaccaaactg ctgcattatctggccaggaatttctacaacctgaggctccttgctctgtttgtggccttc gctatcaacttcatcctgcttttctataaggtcactgaagaacctttagaagagacagag gatgtggcgaacctgtggaattcctttaatgaggaggacgaggaagaagccgtggtgttc tttgtcctgcaggagagcaccggctacatggcgccggccctgggagctctggccgtggtc cacaccgtcatctccctcgtctgtgtggtgggatattactgcctgaaggtgcctttggtg gtattcaaaagggagaaggagattgcccggaagctggagtttgacggcctgtacatcact gagcagccgtcggaggatgacatcaagggccagtgggaccgcctggtggtcaacacgcca tctttccctaataactactgggacaagtttgtgaagagaaaggtgatcaacaagtatgga gacctctatggagcagagcgaattgctgaactcctgggtctggacaaaaacgccctggac ttcagcccagtggaggagaccacagcagaggcagcatctttggtctcatggctaagttcc attgacatgaagtaccacatctggaaactgggggttgtttttactgacaattcctttctg taccttgcctggtatacaaccatgtcggtcctgggccactacaacaacttcttcttcgct gctcatctgctggatatcgccatgggcttcaagacattaaggacaatcctttcatctgta actcacaatggcaaacagttggttcttacagtgggcctcctggctgtggtggtttatctc tacaccgtggtggctttcaacttcttccgcaagttctacaacaaaagtgaggatgatgat gagcccgacatgaagtgtgatgacatgatgacgtgttaccttttccacatgtacgtggga gtacgagcagggggcggcatcggcgatgaaatcgaagaccccgctggcgacccttatgaa atgtaccgcattatcttcgacattacctttttcttctttgtcattgtcatcctgctggcc atcattcaaggtctcatcatcgacgcgtttggagagctgagagaccagcaggaacaagtt cgcgaagacatggagactaaatgtttcatctgtggcattggcaatgactactttgatacg actcctcatggttttgaaacacacacattacaagagcacaacctagccaactacttgttc tttctgatgtatttaattaataaggatgaaacagagcacacgggtcaggagtcgtacgtg tggaagatgtaccaggagaggtgctgggacttcttcccagctggcgactgctttcgtaag caatacgaagaccagcttgcgtag

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