KEGG   DISEASE: 気胸
エントリ  
H01110                                                             
名称    
気胸
概要    
Pneumothorax is defined as air or gas accumulated in the pleural space and can be classified as spontaneous or traumatic. Traumatic pneumothorax includes iatrogenic cases caused during procedures such as pacemaker insertion. Spontaneous pneumothorax can be subclassified as primary or secondary. Primary spontaneous pneumothorax (PSP), which is defined as a pneumothorax without underlying lung disease, predominantly occurs in young, thin males. It is usually caused by ruptured pleural blebs or bullae. Approximately 10% of patients with PSP have a positive family history. Gene mutations in folliculin (FLCN) have been found.
階層分類  
ヒト疾患 [BR:jp08402]
 呼吸器系疾患
  肺疾患
   H01110  気胸
ICD-11 による疾患分類 [BR:jp08403]
 12 呼吸器系の疾患
  胸膜, 横隔膜または縦隔の疾患
   CB21  気胸
    H01110  気胸
関連パスウェイ
hsa04150  mTOR signaling pathway
病因遺伝子 
FLCN [HSA:201163] [KO:K09594]
環境要因  
Smoking
コメント  
PSP might be associated with some congenital disorders such as Marfan syndrome [DS:H00653].
リンク   
ICD-11: CB21
ICD-10: J93.1
OMIM: 173600
文献    
PMID:22343477 (description, environmental factor)
  著者
Grundy S, Bentley A, Tschopp JM
  タイトル
Primary spontaneous pneumothorax: a diffuse disease of the pleura.
  雑誌
Respiration 83:185-9 (2012)
DOI:10.1159/000335993
文献    
PMID:20872980 (description, gene, environmental factor)
  著者
Luh SP
  タイトル
Review: Diagnosis and treatment of primary spontaneous pneumothorax.
  雑誌
J Zhejiang Univ Sci B 11:735-44 (2010)
DOI:10.1631/jzus.B1000131
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