KEGG   DISEASE: うつ病
エントリ  
H01646                                                             

名称    
うつ病
概要    
Major depressive disorder (MDD) is the most common psychiatric disorder mainly characterized by depressed mood, loss of interest, feelings of worthlessness, and a high risk of suicide. Accumulated evidence suggests that both environmental and genetic factors are involved in the etiology of MDD although the pathogenesis of MDD remains unknown. Mutations in genes involved in brain serotonin synthesis, have been identified in patients. Brain serotonin deficiency has been hypothesized to play a role in a wide range of psychiatric diseases, including MDD. Several efficacious treatments for MDD are available, including different forms of psychotherapy and antidepressant medication. Recently, selective reuptake inhibitors (SSRIs, SNRIs,) have become the first-line antidepressant drug treatment of depression and replaced tricyclic antidepressants (TCA) and monoamine oxidase inhibitors (MAOI) due to fewer side-effects and ease of use.
カテゴリ  
精神及び行動の障害
階層分類  
ヒト疾患 [BR:jp08402]
 その他の疾患
  精神及び行動の障害
   H01646  うつ病
ICD-11 による疾患分類 [BR:jp08403]
 06 精神, 行動, 神経発達の障害
  気分症
   抑うつ症
    6A70  単一エピソードうつ病
     H01646  うつ病
    6A71  反復性うつ病
     H01646  うつ病
関連パスウェイ
hsa04726  Serotonergic synapse
病因遺伝子 
TPH2 [HSA:121278] [KO:K00502]
HTR2A [HSA:3356] [KO:K04157]
FKBP5 [HSA:2289] [KO:K09571]
治療薬   
ジアゼパム [DR:D00293]
クロルジアゼポキシド [DR:D00267]
ブロマゼパム [DR:D01245]
メタンフェタミン塩酸塩 [DR:D02242]
レボメプロマジン塩酸塩 [DR:D01520]
レボメプロマジンマレイン酸塩 [DR:D02248]
イミプラミン塩酸塩 [DR:D00815]
クロミプラミン塩酸塩 [DR:D00811]
トリミプラミンマレイン酸塩 [DR:D02408]
ロフェプラミン塩酸塩 [DR:D01285]
スルピリド [DR:D01226]
アリピプラゾール [DR:D01164]
エチゾラム [DR:D01514]
アミトリプチリン塩酸塩 [DR:D00809]
ノルトリプチリン塩酸塩 [DR:D00816]
ドスレピン塩酸塩 [DR:D01546]
アモキサピン [DR:D00228]
マプロチリン塩酸塩 [DR:D00818]
パロキセチン塩酸塩水和物 [DR:D02260]
セルトラリン塩酸塩 [DR:D00825]
フルボキサミンマレイン酸塩 [DR:D00824]
エスシタロプラムシュウ酸塩 [DR:D02567]
トラゾドン塩酸塩 [DR:D00820]
ベンラファキシン塩酸塩 [DR:D00821]
塩酸デュロキセチン [DR:D01179]
ボルチオキセチン臭化水素酸塩 [DR:D10185]
ペモリン [DR:D00744]
セチプチリンマレイン酸塩 [DR:D02034]
リンク   
ICD-11: 6A70 6A71
ICD-10: F32 F33
MeSH: D003863
OMIM: 608516
文献    
  著者
Hou Z, Song X, Jiang W, Yue Y, Yin Y, Zhang Y, Liu Y, Yuan Y
  タイトル
Prognostic value of imbalanced interhemispheric functional coordination in early therapeutic efficacy in major depressive disorder.
  雑誌
Psychiatry Res 255:1-8 (2016)
DOI:10.1016/j.pscychresns.2016.07.011
文献    
  著者
Sachs BD, Rodriguiz RM, Tran HL, Iyer A, Wetsel WC, Caron MG
  タイトル
Serotonin deficiency alters susceptibility to the long-term consequences of adverse early life experience.
  雑誌
Psychoneuroendocrinology 53:69-81 (2015)
DOI:10.1016/j.psyneuen.2014.12.019
文献    
  著者
Lin CX, Hu Z, Yan ZM, Li W, Chen YS, Zhao JH, Zhang LQ, Zhao B, Zhong WT, Feng D
  タイトル
Association between HTR2A T102C polymorphism and major depressive disorder: a meta-analysis in the Chinese population.
  雑誌
Int J Clin Exp Med 8:20897-903 (2015)
文献    
  著者
Szczepankiewicz A, Leszczynska-Rodziewicz A, Pawlak J, Narozna B, Rajewska-Rager A, Wilkosc M, Zaremba D, Maciukiewicz M, Twarowska-Hauser J
  タイトル
FKBP5 polymorphism is associated with major depression but not with bipolar disorder.
  雑誌
J Affect Disord 164:33-7 (2014)
DOI:10.1016/j.jad.2014.04.002
文献    
PMID:25159460 (drug)
  著者
Zhang Y, Becker T, Ma Y, Koesters M
  タイトル
A systematic review of Chinese randomized clinical trials of SSRI treatment of depression.
  雑誌
BMC Psychiatry 14:245 (2014)
DOI:10.1186/s12888-014-0245-4
文献    
PMID:23737423 (drug)
  著者
Cuijpers P, Sijbrandij M, Koole SL, Andersson G, Beekman AT, Reynolds CF 3rd
  タイトル
The efficacy of psychotherapy and pharmacotherapy in treating depressive and anxiety disorders: a meta-analysis of direct comparisons.
  雑誌
World Psychiatry 12:137-48 (2013)
DOI:10.1002/wps.20038
文献    
PMID:26572745 (drug)
  著者
Bruno A, Morabito P, Spina E, Muscatello MR
  タイトル
The Role of Levomilnacipran in the Management of Major Depressive Disorder: A Comprehensive Review.
  雑誌
Curr Neuropharmacol 14:191-9 (2016)
DOI:10.2174/1570159X14666151117122458
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