Equus caballus (horse): 100071830 Help Entry 100071830         CDS       T01058                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism ecb  Equus caballus (horse) Pathway ecb04020   Calcium signaling pathway ecb04371   Apelin signaling pathway ecb04713   Circadian entrainment ecb04921   Oxytocin signaling pathway ecb04970   Salivary secretion ecb05010   Alzheimer disease ecb05012   Parkinson disease ecb05020   Prion disease ecb05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:ecb00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     100071830 (RYR3)    04020 Calcium signaling pathway     100071830 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     100071830 (RYR3)   09154 Digestive system    04970 Salivary secretion     100071830 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     100071830 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     100071830 (RYR3)    05012 Parkinson disease     100071830 (RYR3)    05020 Prion disease     100071830 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     100071830 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:ecb04040]     100071830 (RYR3) Ion channels [BR:ecb04040]  Voltage-gated cation channels   Ryanodine receptor    100071830 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_1 EF-hand_7 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  100071830 NCBI-ProteinID:  XP_023476448 Ensembl:  ENSECAG00000013267 VGNC:  22644 LinkDB All DBs Position 1:155461506..155945901 Genome browser AA seq 4865 aa AA seqDB search MAEGGEGGEDEIQFLRTEDEVVLQCIANVHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVP PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAILLRHSFSGMYL TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVFSER YLHLSISNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD QNDSQHRRVFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED QGLILQDRGKSDTKSTAFSFRASKEIKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHVSS GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQQEESQAARIIRNTTALFSQ FVSGNNRTTAPVTLPIEEVLQTLQDLIAYFQPPEEEMQHEDKQNKLRSLKNRQNLFKEEG MLALVLNCIDRLNIYNSVAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSN NLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIKSIISLLDKHGRNHKVLDV LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASINQHLLKSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVVS FSAGVKVRFLMGGRHGEFKFLPPTGYAPCYEALLPKEKMRLEPVKEYKRDAEGVRDLLGT TQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKNYMMS NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV PYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRFFRVERSY AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGSRGQRWHQGSGYFGR TWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICSLGLSQIGR MNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVVRID GTMDSPPCLKVTHKTFGTQNSNANMIYCRLSMPVECHASFSHSPCLDSDAFQKRKQMQEI LSHTTTQCYYTIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHE SVKRSNCYMVWGGDIVATSQRSSRSNVDLEIGCLVDLAMGMLSFSANGRELGTCYQVEPN TKVFPAVFLQPTSTALFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDIQTIQPVLW SRMPNSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMLFHYH TLRLYSAVCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLASAKE RKQMMKNEYIIPITSSTGKIRLYPDESKRHGLPGVGLRTCLKPGFRFSTPCFVVTSEEHQ KQSPEIPLEILKTKALSMLTEAVQCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDD DSVRQILLLIDPSVFGEHSGEMEEGAEKEEVTQVEEKAVEAGEKASKEAPVKGLLQTRLP ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTA RKTREFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLIHCGVPLEEEEEEEED TSWTGKLRALVYKIKGPPKPEKELPTEEEERCPTTLKELISQTMIRWAQEDQIQDAELVR MMFNLLRRQYDSIGELLQALRKTYTISQASVSDTINLLAALGQIRCLLSVRMGKEEELLM INGLGEIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGAEKSQIAFPKMVASCCRFLCYF CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGFTPLDVAASSVMDNNELALGLEEPDLE KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVSTEDAEDDEIVHM GNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPS LNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDT VSLSTTEAALALNRYLCSAVLPLLTRCAPLFAGTEHYTSLIDSTLQTIYRLSKGRSLTKA QRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCLP SGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDQDLFRMALPCLSAIAGALPPDYLDTR ISATLEKQVSVDADGNFDPKPINTVNFSLPEKLEYIVTKYAEHSHDKWACDKSQNGWKYG ISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTIERTKEGEALVQQREN EKLRSVSQASQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGGG SHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGIVVSRGMKDMELDASSMEKRFAYKFL KKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLSS PLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRTV MKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPIL TSIFEHVAQHQFGVDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAA IPVAFLEPTLNRYNPLSVFNTKTPRERSILGMPDTVEEMCPDVPQLEGLMKEINDLAESG ARYTEMPHVIEVILPMLCNYLSYWWERGPEHLPPSTGPWCTKVTSEHLSVTLGNILKIIN NNLGIDEASWMKRIAVYAQPIISKARPGLLRSHFLPTLEKLKKKAVKTVQEEEQLKADSK GDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDAYSDQLFRMVAEIFIL WCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKSGGQDQERKKTKRRGDLYSIQTSL IVAALKKMLPIGLNMCTPGDQELISLAKSRYSYKDTDEEVKEHLRNNLHLQEKSDDPAVK WQLNLYKDVLKSEEPSNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSKQRKRA VVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEEEEEEET EKQPDPLHQIILHFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEEEEEEEDKEKTFEE KEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAGVQQK MLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERGEKIL QNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESISDFYW YYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHV FANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNV EMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYIQSEIDFLLSCA EADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKSLLDPAESVLNYFE PYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELFV NFCEDTIFEMQLASQISESDSADRPEEEEQAEEDSSYMLEIEGEEEDDRSFESVSAFAMA CASVRRNVANFLKRATLKNLRKQYRKVKKMTVKELVKVFFSFFWTLFVGLFQLFFTILGG IFQILWNTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDALEAERAEVTEPGIATELV YFVKGEKGDADIMSDLFGYHSKKESGLKHGPEVGLGDLSEIIGKDEPPTLESAVQKKRKA QAAEMKAAHEAEGKVESEKADMEDGEKEDTAKEEVQAEALWAEATKKKKRRCGQKVEKPE AFMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEEETEDV ANLWNSFNDEEEEEAMVFFVLQESTGYMAPTLRALAIIHTIISLVCVVGYYCLKVPLVVF KREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGDL YGAERIAELLGLDKSALDFSPVEETKAEAASLVSWLSSIDMKYHIWKLGVVFTDNSFLYL AWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYT VVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMY RIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTP HGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQY EDQLG NT seq 14598 nt NT seq  +upstreamnt  +downstreamnt atggccgaagggggagaaggaggcgaggacgagatccagttcctgcggactgaggatgaa gtggttcttcagtgcattgcgaacgttcacaaggagcaaaggaagttctgcctggcagcc gagggacttgggaatcgcctgtgcttcttggaacctacttcagaggccaagtatgttcct ccagatctctgcgtctgcaattttgtgctggaacagtccctttcagtcagagccctgcag gaaatgcttgccaacacaggtgaaaatggcggcgaaggggcagcacaagggggtggccac aggaccctgctctatggccacgcgattctcctacgacactctttcagtggaatgtatcta acatgtttgactacatcaagatcccagacagataaacttgcctttgatgtaggtctgcgg gaacacgccacaggagaagcctgttggtggaccatacatcctgcttccaaacagaggtct gagggagagaaagttcgaattggtgatgacctcatcctcgtcagtgtgttctctgaaaga taccttcatctctcgatatcaaatggtaacatacaagtggacgcctcctttatgcaaaca ctctggaatgtacatcctacgtgctcaggaagtagcatcgaagaaggatacctacttggt gggcatgtagtacgtcttttccatggccacgatgagtgtttgacgataccatctacagac cagaatgattcccagcacaggagggtattctatgaagctggcggagctgggacaagagcc agatctctgtggagagtggaaccccttcggataagctggagtggcagtaacatcagatgg ggccaggctttccgactccgacatctcaccacaggccactacctggccttgacagaggac caaggccttatactgcaagaccggggaaagtcagacaccaagtccacagccttctctttc cgagcatcaaaggaaatcaaggagaaattggattccagtcacaagcgagatatagaaggc atgggagttccagaaatcaagtatggagattctgtctgctttgtccagcatgtttccagt ggtctgtgggtgacctacaaagcacaagatgctaagacatcccgccttggacctctgaaa agaaaggtcatcctccatcaggaaggccacatggatgacggattaacgctgcagagatgc cagcaggaggagtcccaggctgctcggatcatccggaacacaacagccttgttcagccag tttgtaagtggaaacaatcgcacgactgctcctgtcaccctgccaatagaagaggtcctg cagaccttacaggacttgatcgcctacttccagcccccggaggaggagatgcagcatgag gacaagcagaacaaactccgctcactgaaaaatagacagaatcttttcaaggaagaggga atgttggctctagtgttaaactgcattgatcgcttaaatatctacaacagcgtagcacac tttgcagggattgcaagagaagagagtggcatggcctggaaagaaattctgaaccttctg tacaaattgctggctgccctcattcgtggaaacagaaacaattgcgctcaattctccaat aaccttgattggctaatcagcaaattggacagactagaatcttcctcaggtatcttggaa gttttgcactgcatcctgattgaaagcccagaagccttaaacctgatagcagagggccac atcaagtccatcatctccctgttggataagcacggacggaatcacaaggttctggatgtg ctgtgctccctctgtctctgcaatggggtcgcagtgagagccaaccagaacctgatctgt gacaacttgctgccccggagaaacctgctcttgcagacacggctgattaacgatgtgaca agtattcgaccaaacatcttcctgggagtcgctgagggctcagcgcagtataaaaagtgg tacttcgagctaattatcgaccaggtggaccccttcctaacagcagagcccacacaccta cgggttggctgggcctcttcctcaggctatgctccataccccggaggtggagaaggatgg ggcggcaatggtgttggcgatgacctgtactcctatggctttgatgggcttcacctttgg tctggccggatacccagagctgtggcctccatcaaccagcacctcctgaaatcggatgac gtggtgagctgctgcctcgacctgggagtgcccagcatctctttccgcatcaacgggcag cctgtgcaggggatgtttgaaaacttcaacacagatgggctcttcttccctgtggtgagc ttttcagcaggtgtcaaagtacgttttctgatgggcggacgtcacggagaatttaagttc ctgcctcccactggctatgccccttgctacgaagccctacttccaaaagaaaagatgaga ctggagcccgtcaaagaatataaacgtgatgctgaaggtgttagagatcttctgggtacc acccagttcctctcccaagcctctttcatcccatgccccatagacaccagtcaggttgtt ttgccacctcacctagagaagatccgagacagactggctgaaaacatccacgagctttgg ggaatgaataaaatagagctgggctggacttttggcaagatacgggatgacaataaaaga caacacccctgccttgtggagttttccaagctccccgaaactgagaagaattataacctg caaatgtcaactgaaaccttaaaaaccctcctggccctggggtgccacattgctcatgtt aatccagccgcagaggaggatctcaagaaggtcaaactgcccaaaaactacatgatgtcc aatggctataagccagcccctttggatttgtctgatgtgaagctgttacctcctcaagaa attttagtggataagcttgcagaaaatgcacataatgtttgggcaaaagacagaataaaa caaggatggacctatggcattcaacaggatttgaagaacaaaagaaatccccgtctggtg ccatatgcattactggatgagcgtaccaaaaagtcaaacagggacagccttcgtgaagct gttcggacatttgttggttatggctataacatcgagccatcagaccaagaactagctgac ccagctgtggagaaagtcagcatagacaagatccgatttttccgggtagagcggtcttac gctgtgagatctggcaagtggtattttgagtttgaggtggtgaccggaggagacatgcgc gtcggctgggccaggccaggctgtcggcctgacgtcgagctgggggccgatgaccaagcc tttgtgtttgaaggcagcaggggccagcgttggcatcaagggagtgggtattttggacgt acctggcagccaggagatgtggttggatgtatgattaacctggatgatgcttcgatgatc ttcacgctgaatggggagctgctcatcaccaacaaaggctctgaacttgcctttgctgac tacgagattgagaatggctttgtgcccatctgctctctgggactgtctcagattggccgc atgaatctcgggatggatgccagtaccttcaagttttataccatgtgcggcctacaagag ggctttgagcctttcgctgtcaacatgaaccgagatgttgcgatgtggttcagcaagcgc ctcccaacgtttgtcaacgtcccaaaggatcatccacatatagaggtcgtgaggatcgat ggcaccatggacagcccgccatgcctcaaggtgacccacaagacgtttggcacacagaat agcaatgccaacatgatctactgccgcctgagcatgcccgttgagtgccatgcctccttc agccacagcccctgtctggacagtgatgctttccagaaaaggaaacagatgcaagaaata ctctctcatacaacaacacagtgctactacacaatccgcatctttgctggccaggacccc tcctgcgtctgggtcggatgggtgactccggactatcacttgtacagtgaaaagtttgac ctgaataaaaactgtacggtgactgttactctaggggatgaaagaggccgggtccacgaa agtgtgaagcgcagcaattgctacatggtctgggggggagacattgtggccacttcccaa agatcaagtcggagcaacgtggacctggagattggctgcctcgtggatctggcgatgggc atgttgtctttctcggccaatgggagagaacttggcacctgctaccaggtggagcccaat accaaagtgttcccagccgtcttcctgcagcccacaagcactgctttatttcagtttgaa cttgggaagctgaagaatgcaatgcccctgtcagcggccatatttaagagtgaagagaag aacccagtcccacagtgcccacctcgcctggacatccagaccatccagcccgtgctctgg agccgcatgcccaacagcttcctgaaggtggagacagagcgggtgagcgagcgccatggc tgggtggtgcagtgcctggagcccctgcagatgatggcgctccacatccctgaggagaac aggtgtgtggacatcctggagctctgcgagcaagaagacctgatgctcttccattaccac actctgagactctacagcgctgtgtgtgccctgggaaacagccgagtggcctacgccctg tgcagccacgtggacctctcccagctcttctacgccattgacaacaagtacctccccggc ctccttcggtctggtttctatgacctgcttatcagtatccatctggccagtgctaaagag aggaagcagatgatgaagaatgagtacatcatccctatcacaagctccaccgggaaaatc cgcctgtacccagatgagtccaagaggcacggactgcctggggtaggcctgagaacatgc ctcaagccaggcttcaggttctccaccccttgctttgttgtgaccagcgaggagcaccag aaacagagccccgagattcccttggagattctcaagacaaaggctctgagcatgctgaca gaggcagtgcagtgcagtggcgctcacatccgggaccctgttggggggtctgtggagttc cagtttgtgcctgtgctgaaactcatcggaaccctgctggtcatgggggtgtttgacgat gacagcgttcggcagatcctcctcctgatcgatccctctgtgtttggcgagcacagtggg gagatggaggagggagcagagaaggaagaagtgacccaggtggaggagaaggcagtggag gctggggaaaaggccagcaaggaggctccagtcaaaggcttattacagacccgattacca gagtccgtcaagctgcagatgtgtgagctcctcagctacctctgtgactgtgagctgcag caccgagtggaggccattgtggcatttggcgacatttatgtctccaagctccaggcaaat cagaagttccgctacaatgagctcatgcaggccctgaacatgtctgcggccctgacagcc cggaagaccagggagttccgctcacccccacaggagcagatcaacatgcttcttaacttt caactgggagagaactgcccctgcccagaagagatccgggaggagctctatgatttccac gaagaccttctcattcactgtggggttcccttggaggaagaggaagaggaggaagaggac acctcctggactgggaaactccgtgccttggtgtataaaatcaaaggccctcccaagcca gagaaggagcttccaacggaggaggaggagagatgccctacgacactgaaggagctcatc tcacagacaatgatccgctgggcccaggaggaccagatccaggatgcggagctggtccgg atgatgttcaacctcctccggaggcagtatgacagcattggggagcttctgcaggcgctg cggaagacctataccatcagccaggcctctgtgagcgacaccatcaacctgctggctgcc ctgggccagattcgctgcctcctcagtgtcaggatgggcaaggaagaggagctgctcatg atcaacgggctgggagagataatgaacaacaaggtgttttatcagcaccccaacctcatg agggtcctcggcatgcatgagacggtgatggaagtgatggtgaacgtgttgggtgcagag aaatctcagattgcttttccaaagatggttgctagctgttgccgcttcctttgttatttc tgtcgaattagccggcaaaatcagaaggccatgtttgagcatctaagttacctgctggag aatagcagtgttggcctagcatccccatcgatgaggggattcaccccgctggatgtggca gcttcctctgtgatggacaacaacgagttagctctgggcttagaggaaccagaccttgag aaggtggtgacctacttggcaggctgtggcctgcagagctgccccatgcttctggccaaa ggataccctgacgtcggctggaaccccattgaaggggagcgctacctgtccttcctgagg tttgccgtcttcgtgaacagtgaaagtgtggaagagaatgctagtgtcgtggtcaagctg ctcatcagacgcccagagtgctttggcccggcgctgcggggtgaaggaggaaacggtctg ttggcagccatgcagggcgccatcaagatctctgagaacccagccctcgacctcccctct cagggatacaagagagaagtcagcacggaggatgctgaagatgacgagatcgtgcacatg ggcaatgcgattatgtccttttattcggctcttatagatctgctgggccgctgtgctcct gaaatgcaccttatccagacaggaaagggggaagccatccggatcaggtcaatcctgcgc tccctggtccccaccgaagacttggttgggatcatcagcatccccttgaaactgccatcc ctgaacaaagatgggtcggtcagcgagccagacatggctgccaacttctgccctgaccac aaggcacccatggtgctgttcttggaccgcgtttatggcatcaaggatcaaactttcctg ctccacttgctggaggttggatttttacctgacttaagagcctctgcctctctagacaca gtttccctgagcaccacagaggcggcgctggcactgaacaggtacctatgttccgccgtg ctcccactcctcacaagatgcgccccgctctttgctggaacagaacactacacctcgctg atcgattccacactacagacaatatacaggctttccaagggccgttccctcaccaaagct cagagggacaccatagaagaatgtttgcttgccatttgcaaccacttgaggccttccatg ttacagcaactcctgcgacgtcttgtttttgacgtgcctcaactcaacgagtactgcaaa atgcctcttaagctgctgacgaatcactatgaacagtgctggaagtattactgtctgcct tccggatgggggagctacggcctagctgtggaggaagagctacacctgaccgagaagctc ttctgggggatttttgactccctctcccataagaagtatgaccaagatcttttccgaatg gccctgccttgtctcagtgctatagctggggccttgccaccagattatttagataccagg atctcagccacattggagaaacaggtctccgtggatgcagatggcaactttgaccccaaa cctatcaacaccgtgaatttctccttgcctgaaaaattggaatatatcgtcaccaagtat gctgagcattcacatgataaatgggcctgtgacaagagtcagaatggatggaaatatgga atttccctggatgaaaatgtgaagacacatccgttgataaggcctttcaagacgttaacg gagaaggagaaggaaatttatcgctggcctgccagagagtccctgaaaaccatgctggct gtgggctggaccatagagaggaccaaagaaggagaagccctagttcaacagcgggaaaac gagaagcttcgcagcgtgtcccaggccagccagggcaacagctacagtcctgctcccctg gacctatccaacgtcgtgctctccagagagctccagggaatggtggaagtcgtggctgag aactatcacaatatctgggccaagaagaagaagctggagctggagagcaaaggtggtggc agtcaccctcttttagtgccatatgacaccttgactgccaaggaaaagttcagagaccga gagaaggcgcaggacctgtttaaattcctccaggtgaatggcatcgtggtctctagaggt atgaaggatatggaactggatgcctcctccatggaaaagaggtttgcctacaaatttttg aagaagatcctgaaatatgttgattccgctcaagagtttattgcccatttggaagccatt gtcagcagtgggaaaacagaaaagtcgccacatgaccaggagatcaaattctttgccaaa gttcttctcccactggttgaccagtacttcaccaatcaccgcctctacttcttgtcctcc cctctgaagcccctgagcagcagcgggtatgcctcccataaggaaaaagaaatggtggcc agcctgttctgcaaactcgctgctcttgttcgacacaggatttccctctttgggagcgat tccactacaatggtgagctgtcttcacatcttagctcagacacttgacacaaggactgtc atgaagtcaggctcagagctggtgaaggccgggttacgagccttctttgaaaatgccgca gaagacttagagaagacctcggaaaacctgaagctcgggaagtttacccattccagaacg cagattaaaggcgtttctcagaatattaactacaccacagtggctctgcttcccatcctg acgtccatctttgagcacgttgctcagcatcagttcggggtggacttactcttgggcgac gtgcagatttcatgctaccacatactgtgcagcctctattcccttgggacaggaaagaac atctatgttgaaaggcaacgtcctgcccttggagaatgtctggcctcactggcagctgcc ataccagtggcattcctggagcccacccttaaccgctacaatccactttcggtcttcaac accaaaacccccagggagaggtctattctggggatgccagacacggtggaagagatgtgt cctgacgtcccccagctggaaggcctaatgaaggaaatcaatgacctggccgagtcaggg gcccggtacacggagatgccgcatgtcatcgaggtgatcctgcccatgctctgcaactac ctgtcctactggtgggagcgggggcctgagcatctgccccctagcacagggccctggtgc accaaggtcacctctgaacacctcagtgtcaccctgggcaacattctgaaaatcatcaac aacaacctgggcatcgacgaggcctcctggatgaagcgcattgcagtgtatgcccagcct atcatcagcaaagccaggcctggcctgctgagaagccacttcctcccaactctggagaag ctgaagaaaaaagctgtcaagaccgtgcaggaggaggagcagctgaaagccgacagtaaa ggtgacactcaggaggcggagcttctcatcctggatgagttcgcagtcctctgcagagac ctctacgccttctaccccatgctgatccgctacgtggacaacaacagatctaactggctc aaaagccccgatgcttattctgaccagctcttccgcatggtggccgagatcttcatcctg tggtgtaaatctcataacttcaagagggaagagcaaaattttgtcattcagaatgaaatc aacaacttggcgtttttaaccggagacagcaaaagcaagatgtcaaaatctggaggacag gaccaggaacggaagaagacaaagcggaggggagacttgtattccatccagacctccctc attgtggctgcgctcaagaaaatgctgcccattggtttgaacatgtgcactccaggcgat caggagctgatctcccttgcaaaatcacgatacagctataaggacacagatgaagaggtg aaggaacatctgcggaataacttgcacttgcaggaaaagtctgacgatccagccgtaaag tggcaactgaacctctacaaagatgttttgaagagtgaagagccttccaatccagaaaag acagtggaacgtgtgcagagaatttcagcagctgtcttccacctggagcaggtggaacag cctttgaggtccaagaaggcagtctggcacaaactgttgtcaaagcagcggaaacgggca gtggtggcctgtttcaggatggcccctctctacaacctgcccaggcaccgctctattaac ctcttcctccatggctatcagagattttggatagaaacagaggagtattcctttgaagag aaactagtacaggatttggctaaatcccccaaggtggaagaggaagaggaggaggagaca gaaaagcaaccagatccacttcatcagatcattctccattttagccgcaatgctctcacg gagaggagcaaattggaagacgaccctttgtacacctcctattccagcatgatggccaag agttgtcagagtggggaggaggaagaagaagaggaagacaaggaaaaaacatttgaagag aaagagatggaaaagcagaaaaccctctatcagcaagctcggctacatgagcgtggagcc gcagagatggtccttcagatgataagtgccagcaaaggggagatgagccccatggtggtt gaaactctgaagctggggatcgccattctgaatgggggcaacgctggcgtgcaacagaaa atgctagattacctaaaggaaaaaaaggatgctggattctttcaaagcctttctggcctc atgcagtcttgcagtgtccttgatttgaatgcatttgagaggcagaacaaagctgaaggc ctggggatggttaccgaggaaggaacactcattgttcgtgaacgtggtgaaaaaatactc cagaatgacgagtttacacgagatctctttagattcctacagttactttgtgaaggacat aacagtgactttcagaacttcctgcggactcagatgggcaataccaccaccgtgaatgtc atcatcagcactgtggactaccttctgcgtctgcaggaatcaatcagtgatttctactgg tattactcagggaaggacatcattgatgaatctggacagcacaatttttccaaagctctg gcggtcacgaagcagattttcaattctcttacggaatacatccagggcccttgcattggg aaccagcagagcctggctcacagtaggctgtgggacgcggtggtcggcttcctccatgta tttgctaacatgcagatgaaactctctcaggattccagtcagatcgagctgctgaaggaa ctcttggatctccttcaggacatggtggtgatgcttctgtccctcctggaagggaatgtg gtaaatggaactattggcaagcagatggttgacacactggtagagtcatctaccaatgta gaaatgatcttgaaattctttgacatgttcttgaaacttaaagacttaaccagctcagac accttcaaagaatatgacccagatggtaaaggcattatctccaaaaaagaattccagaag gccatggaagggcaaaaacagtacatacagtcggagattgactttctcctttcgtgtgca gaagctgatgagaatgacatgtttaattacattgattttgtagaccggttccatgaacca gccaaggacatagggtttaatgtggcagtgttattgacaaatctctctgaacatatgccg aatgattctcgccttaagagtctgttggacccagcagaaagtgtgctaaattactttgaa ccatacctaggacgcattgagattatgggtggggccaagaaaattgagcgtgtttatttt gagatcagtgaatccagtcgaactcaatgggagaagccccaagtgaaggaatctaagcga cagttcatctttgatgttgtcaatgaaggtggagagcaagaaaaaatggaactgtttgtg aacttctgtgaggataccatctttgaaatgcagttagcatctcaaatctctgagtctgac tcagctgacaggccagaagaggaggaacaggcagaggaagattcttcttatatgttagaa attgagggtgaagaggaggatgacaggtcttttgagtctgtctctgcatttgccatggcc tgtgcctcagtgaggagaaatgttgccaactttctcaagagggcaaccctgaagaacctc aggaagcagtacaggaaggtgaaaaagatgactgtgaaggagctggtgaaagtgttcttc tctttcttctggacgctgttcgtggggctcttccaattattcttcaccatattgggaggt atctttcagatcctctggaacacagtgtttggagggggcctagtagaaggggcaaagaac atcagagtgaccaagatcctgggtgacatgcctgacccaacccaatttggtatccatgat gatgctttggaggctgagagggcagaagtgaccgagccaggtatcgcaactgaactggta tacttcgtaaagggtgagaaaggagatgcggatattatgtcagatctctttggataccac tcaaagaaagaaagtggtttaaagcatgggcccgaagtaggtttgggtgacctctctgag attattggcaaggatgaaccccctacgctagagagtgctgtacagaagaaaaggaaagca caggcagcagagatgaaagcggcacatgaagcagaaggaaaagtagagtctgagaaggca gacatggaagatggagagaaggaggatacagccaaagaagaagtgcaagccgaggccctg tgggccgaagcgacaaagaagaagaagcgacggtgtggccagaaagttgagaagcctgaa gccttcatggccaatttctttaaaggactggaaatctatcagaccaagctactgcattac ctggccaggaatttctacaacctgaggttccttgctctgtttgtagccttcgctatcaac ttcatcctgctcttttacaaggtcactgaagaacctttagaagaagagacagaggacgtt gcgaacctgtggaattcctttaatgatgaggaagaggaagaagcaatggtgttctttgtc ctacaggagagcactgggtatatggcaccaacgttgcgggccctcgccattatccacacc atcatctctttagtctgtgtggtgggctattactgcctgaaggttcccctggtggtcttc aaaagggaaaaagaaattgccaggaagctggagttcgatggcctgtatatcaccgaacag ccatctgaagatgacatcaagggacaatgggaccgcttggtaatcaacactccatctttt cctaataactactgggacaagtttgtaaagagaaaggtgatcaacaagtatggagatctc tacggagcagagcgcattgctgaactcctgggtttggacaaaagtgcccttgattttagc ccagtagaagagaccaaagctgaggcggcctctctggtgtcatggctaagttccattgac atgaagtaccatatctggaagctaggagttgtttttactgacaattcctttctctacctt gcctggtacacaaccatgtcagtcctgggccactacaacaacttcttcttcgctgctcat ctgctggatattgcaatgggcttcaagacactgaggactattctgtcatctgtgacccac aacggcaaacagctggttctgactgtcggtctcctggctgtggtggtttatctctacacc gtggtggctttcaactttttccgcaagttctacaacaaaagcgaagacgacgatgagccg gatatgaagtgtgatgacatgatgacgtgttacctattccacatgtatgtgggagtgaga gctggaggtggcattggcgatgaaattgaagaccctgctggcgatccttatgaaatgtac cgcattgtctttgacattaccttcttcttctttgtcattgtcatcttgctagccatcatt caaggtcttattattgatgcttttggagagctaagagaccagcaggaacaagtgagagaa gatatggagactaaatgtttcatctgtgggattggcaatgactactttgacacgacccct catggttttgaaacacataccttacaagagcacaacttagccaactatttgttcttcctg atgtatttgattaataaagatgaaacagagcacacgggtcaggaatcctacgtctggaag atgtaccaagaacggtgttgggatttcttcccagctggtgactgcttccggaaacaatat gaagatcagcttggataa

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