Esox lucius (northern pike): 105024326 Help Entry 105024326         CDS       T04894                                  Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism els  Esox lucius (northern pike) Pathway els04020   Calcium signaling pathway els04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:els00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     105024326    04020 Calcium signaling pathway     105024326  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:els04040]     105024326 Ion channels [BR:els04040]  Voltage-gated cation channels   Ryanodine receptor    105024326 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 Ins145_P3_rec SPRY MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  105024326 NCBI-ProteinID:  XP_028972792 LinkDB All DBs Position LG23:4923183..5040942 Genome browser AA seq 4858 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQSVATIQKENRKFCLSVEGLGNRLCFLEPTSEAKYVPP DLCICCFILEQSLSVRALQEMLAHTGPNEGKANHEQWAAQGGGHRTLLYGHAILLRHSFS GMYLTCLKTSRSLTDKLSFDVGLQEDSIGESCWWTIHPASKQRSEGEKVRIGDDLILVSV STERYLHLSISNGSFQVDASFMQTLWNVQPTCSGSNVAVGFLCGGHVMRLCHGHDESLTI PGSKASEMEQRIVNYEMGKGTSRARSLWRLEPLRIGWSGSHIRYGQAFRLRHLSTGHYLA LTEDHGLVLQDRGKSDTKSTAFCFRATKEKIEAGTKNRDMEGMGVAEIKYGDSVCFVMHV ATGLWLSYQAPDAKASRIGPLKRRACLHAEGHMDDGLTLQRCQHEEARAVRIIRNTTVLF SQFIRGLDSIAGDKNVEVSLPDLDEVLQTLDDLIEYFKQPDSELEHEEKQTLLRSLIKRQ DLFKEEGMLTLLVKCIDRLNLYNSAAHFGEHAGEEAGAAWKNILNLLYELLASLIKGNRN NCTQFSKNLDWLVSKLERLESSSGILEVLHCILIESPEALNIIQKAHIKSIISLLYKHGR NHKILDVLCSLCVCNGVAVRANQNLICDHLLPKRDLLLQTRLVNDVQSMRPNIFLGMAEG SAQYRKWYYELMIDQVDHFVTSEPSHLRVGWASSKGYAPYPGGGEGWGGNGVGDDLYSYS FDGLHLWSGRVPRAVASINQHLLNSDDVVSCCLDLGAPSISFRINGQPVQGMFEDFNTDG FFFPVVSFSAGVKVRFLLGGRHGDFKFLPPAGYSPCYEALLPKEKMSVEAVKDYKRDHGG VRDLLGTTQLLSQASFIPTPVDTSQIVLPSHLENVRDRLAENIHELWGMNKIELGWSYGK VRDDNKRQHPCLVDFTKLPETESNYNLQMSSETLKTLLALGCHVAQTNVNAVDDLKKVKL PKEYVMSNGYKPTPLDLSEVKLTAGQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDVKS RRNPRLVPYALLDERTKKSNRDSLREAIRTLVGYGYNIDPPDQEACHVVERQSIETIRFF RVEQTYAVKTGKWYFEFEAVTGGDMRVGWARPGCRSDFDLGMDDQAFVFDGFKARRMHMG ATSFGRSWSPGDVVGCMISMEDKSMMFTLNGELLITNKGSELCFIDFETEDGFIPVCCIT QSQVGRMNLGKDASTFKYYTMCGLQEGFEPFAVNMNREVTMWFSKRLPTFVNIPKDHLHI EVTRIDGTVDNPPCLKVTHKTFGTQQSNSDMLYCRLSMPVEFHARDVNAEESQKLSQPPK EDDYGSITTYFHSVRVFAGQDPASVWVGWVTPDYHYISKNFSLNKTRTVTVTLGDERGRV HESVRRSNCYMVCAGDVASASHSSSRSNVDLEIGCFVNLATGLIAFTANGKELATTYEVE SNTKLFPAVFVRPTSPNLFQFEFVKIKNAMPLSSAIFKSELRNPVPQCPPRLDIQTMVSV LWSRMPNHFLTVETARVSERHGWVVQCLEPLQMLAVHIPEENRCLDILELSEDEGLRAFH YHTLKLYCALCALGNTRVAHALCSHLDQSQLLYTINNQYLSGMLREGFYDVLISIHLETA KDARLMMNNEFIIPVTDETRSIKLFPDESKRHSLPGVGLSTSLKPRLNFSPLSFITTKKT QHLYSPHIPLGILKDKAISMLTEAVQGGGSHIRDPVGGSVEFQFVPILKLIGTLLIMGVL TSEEVRLILLLIDPNVFGDPPEEEAKVEEAVAVGEKEDVSSNEEKAVEAGEEENKEVKPP VKGLLEKTLPESVKRQMCELLHYFCDCELKQRIEAIVSFSDGFVSKLQFNQKFRYNELML ALNMSAAVTAKKTKEFRSPPQEQINILLNFSAGEDCPCPEEIREELYSFHDELRLHCGIP VEEEEEEQDKSIKGRLLALLYKIKGPPKKKDEQPTEEEQAAPTNLKELISQTMASWAQEC SIQDPELVRVMFSLLRRQYDGVGALLRALRKSYTISAASVQDCVNLLASLGQIRSLLAVR MGKEEEKLMIDGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKSQEIAFPKMV ASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAASSVMDNNSL ALALEEPDLEKVVTYLAGCGLQSCAMLLAKGYPDIGWNPIEGERYLSFLRFAVFCNGESV EENSNVVVKLLIRRPECFGPALRGEGGNGLLAAMLEAIKISEDPALDLPSTAKAQPDGSG EDEEEEEVAHTGNAIMSFYSALIDLLGRCAPEMHLINKGKGEALRIRAILRSLVPTTDLV GIISIPLKMPTVNKDGTVKEPDMSASFCPDHKAPMVLFLDRVYGVEDQTFLLHLLEVGFL PDLRASASLDTDVLSTTETALAMNRYIGSAVLPLLTRCADQFAGTEHYATLIDSTLHTIY RLSKGRSLTKAQRDSIEECLLAICKHLRPSMMQQLLRRLVFDVPLLTEYCKMPLRLLTEH YEQSWKYYCIPSGMGISGMASDDELLLTKKLFWGIFDSLSAKRFDPDLFKTAMACLSAIA GAVPPDYVDASPSATLEKQVSVDAHGNFDPKPINTANISLPEKLDYIANKFAEQSHIKWS SEKVTAGWKTGDVLDEEAKTHPLLKPYKSLSEKEKESYRWPVKESLKSMLAMGWNIERTK EGEAMLIEKQIKMSESTQDNDNGFIPESPMDLSNITLSRELQSMVEVVAENYHNIWAKKK KIELDGKGGGTHSLLVPYDTLTAKEKYRDREKAQDLFKFLQINGYTITRGVKDMEQDSSS MEKRFAYTFLKRLLKYVDSAQEFIAHLEAMATSGKTDKSPHDQQIKFFAKVLLPLIDTYF KNHSMYFLSTPSKNLSSSGYASNKEKEMATSLFCKMAALVRHRISLFGSDTGIMVSCLLI LAHSLDTRTVMKSGSELVKAGVRTFFENAAEDLEKTLEMLKLGKFSHSRSQMKCLSQNIS YATTALLPILTGLFEHITMHKFGVQLLVDDVQLSCYRIVTCLYTLGTGKYIYVERHLPAL GECLATLVGAMPAAFLEPDLNAHNPLSVFNTKTPRERAILSMPDSVVEMCPEMPRLDGLL KDINDISESGARYTEMPQVIEVILPMLCTYLSHWWEKGPENSAPDAACCTTVCSNHLSII LGNILKILNNNLGIDDAPWMKRIAVYSQPIICKAAADLLKSHFLPTLEKLRKKTVKVAAE EELLKADIKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSRWLKRPNAQSNELF NMVAEIFILWCKSHNFKREEQNFVVQNEINNLSFLTGESKTKMSKSGGDQDRKHKRRRGE LYSVQTSLIVAALKKMLPIGLNMCTPGDQELISLAKTRYSLKDTDDEVKDQLRANLHLRD KSDDLAVQWQMNLYKDVVVESDEPTEADNIVDRVQSISAAIYHLEQVEQPLRIKKCILQK LLSKQRKRAVVACFRMAPLYNLPRHRSINLFMLGYQRLWIEAEDYSFEERLVQDLAKTQM KIVEEEEEDEVEVQPDPLHQLILHFSHNALTERSFLEEDPLYIAYADMMAKSCAEDEEEN EEEAKEKTFEEKEMEKQKILYQQARLHARGAAEMVLQMISASKGRLGPMVTCTLKLGISI LNGGNVLVQQKMLDYLKEKRDAGFFKSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGS IKSEQGTKVLTNDDFTKDLFRFLQLLCEGHNGDFQNFLRTQTGNTTTVNIIISTVDYLLR LQESISDFYWYYSGKDIIDEHGQENFSKALAVAKQIFNSLTEYIQGPCIGNQQSLAHSRL WDAVVGFLHVFANMQMKLSQDSSQIELLKELMDLQKDMVVMMLSLLEGNVVNGTIGKQMV DTLVESSSNVEMILKFFDMFLKIKDLTTSDNFREYDPDNKGVISKKEFQKSMENQKQYTQ SEIEFLLSCAEADENDMFNYEEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDPRLATFLE PAESVLNYFEPYLGRIEIMGGGKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEG GESEKMEMFVNFCEDTIFEMQLASQISEPDVVERPEEDEEEVHSFFEELAEEQEESELEA SSAFNMACVSAKKKFSKFKQTLTFKNLKKKYKKFKKLSIKEMIHGFFSFFWMIFTGFFKG IYSIIFGFFHLIWSSMFGGGLVEGAKNMKVTDILGNMPDPTQFGIHGDVLETEKAEVGDS VSGGTDQAIVPVDKAEQDILMELINPAPKKGEGLKHVDPGLGDMAESQTVEKKNLTSTFE KKKAATAAEVKESEPEKADTEKKEKEDKAMVAELKEAVAEEKPVPKSRNGQAKEAPTSFF ASFFVGLEVYQTKMLNTLARNFYNMRFLALFVAFAINFILLFYRVTGDGSDNDEDDSWTS SDDEEEGDDEYFVLEESTGYMAPMLCFLALFHTALSTLCLVGYYFLKVPLVVFKREKGIA RKLEFDGLYITEQPSDDDITGQWDRLVINTPSFPNNYWDKFIKRKVINKYGDMYGAVRIA ELLGLDKSALDFDPTQETVAEEGSLVSWLSSIDTKYHIWKMGVVLTDNSFLYLIWYATMS ILGHFNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFF RKFYNKSEDEAAPDMKCDDMMTCYLFHLYAGVRAGGGIGDELEDPAGDPYELWRILFDIT FFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTTPHGFETHT LQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDLLG NT seq 14577 nt NT seq  +upstreamnt  +downstreamnt atggctgagggcggagaaggggaagatgagattcagttcttacgaactgatgacgaggtg gtgcttcagagtgttgccaccattcagaaagaaaaccgcaagttttgtttgtcagtggag ggactcggaaatcgactgtgcttcctggaacccacatctgaggctaagtatgttccaccc gacctgtgtatctgctgctttatcctggagcagtctctgtctgtccgagccctgcaggag atgttggctcacactgggccaaacgaggggaaagccaaccatgaacaatgggcagcccag gggggcggacaccggaccctgctctacggtcacgccattctcctgcgccactccttcagc ggaatgtacctgacctgtctgaaaacgtcaagatcgttgacggacaaactgtcgtttgat gtggggttacaagaagattcaataggggagtcgtgttggtggaccatccaccccgcatcc aagcagaggtcagagggagagaaggtccggatcggagatgacctcattctggtcagcgtg tccacggagagataccttcacctgtccatctctaacggcagtttccaggtggatgcctcc ttcatgcagactctgtggaacgtccagcccacctgctctggaagcaacgtggcggtcgga ttcctgtgtggtggtcatgtgatgcgtctgtgtcacggacatgatgagagtctgaccata cctggatcgaaggccagcgagatggagcagaggatcgtgaactatgagatgggaaaagga acatccagggcccgctccctgtggaggctggaaccgctcaggatcggttggagcggtagc cacattcgttacggtcaagccttccgtctacgccacctgtccaccggtcactacctggcg ctcaccgaagaccacggcctggttctgcaagatagagggaagtctgacaccaagtccacc gcgttctgcttccgggcgaccaaggagaagattgaagccggcacaaagaaccgggacatg gaaggcatgggggtggcggagatcaagtacggcgactctgtgtgcttcgtgatgcacgtg gccacgggcctttggttgtcctaccaggcccccgacgcaaaagcctcgcgcattggaccc ctgaagagaagggcctgcctgcacgccgagggacacatggatgacggtctgaccctgcag cgctgtcaacacgaggaggcccgggcggtacgcatcatcaggaacaccacggtcctcttc agccagttcatccggggtctggacagcatcgcaggggacaagaatgtggaggtgtctcta cctgatcttgatgaggtgttacagacactggatgatttgattgagtatttcaaacagccc gactcagagctggaacatgaggagaaacagaccctgctgaggtctctcatcaaacgacag gacctattcaaagaggaggggatgttgacgttgctggtgaagtgtatcgaccgtctgaac ctgtacaacagcgccgcccactttggggaacacgcaggggaggaggccggagctgcctgg aagaatatactcaacctgctctacgagctcctggcctctctgatcaaaggcaacaggaac aactgcacccagttctcaaagaacctggactggctggtcagcaagctggagagactggag tcctcatcaggtattctggaggtgctccactgtatcttaattgagtctcctgaagctctg aacattatccagaaggcacacatcaagtccatcatctccctgctctacaaacatggacgc aaccacaagatcctagatgtcctgtgttccttgtgtgtttgtaatggggtagctgtgaga gccaatcagaacctcatctgtgatcacctgcttcctaagagagacctgctcctgcagacg cggttggtcaatgacgttcagagtatgagacccaacatcttcctggggatggcggaggga tcagcccaatacaggaagtggtactatgagctgatgatcgaccaggtggaccacttcgtg accagcgagccgtcacacctgcgcgtgggctgggccagctccaagggttacgccccctac cctgggggtggggagggctgggggggcaacggtgtgggggacgacctgtactcctacagc ttcgatggactccacctgtggtcagggcgggtgccgcgggccgtggcctccatcaaccaa cacctgttgaactctgacgacgtggtcagctgctgcctggacctgggcgctccctccatc tccttcaggatcaacggccagcccgttcagggcatgttcgaagacttcaacaccgacggc ttcttcttccccgttgtcagcttctccgctggggtcaaggtgcgtttcctgttggggggt cgtcacggagacttcaagttcctaccgccggcgggctactccccgtgctacgaggccttg ctccccaaggagaagatgagtgtggaggctgtgaaggactacaagagggaccatggtggg gtcagggacctgctggggacaacacagctcctctcccaggcctccttcatccccacacct gtcgacaccagccagattgttttgccgtctcacctggaaaatgtgcgggacaggctagca gagaatatccatgaactgtgggggatgaacaagattgaactgggatggtcctatggcaag gttcgtgatgacaataagaggcagcatccttgccttgtggatttcaccaaactgcctgaa acagagagcaactacaacctgcagatgtccagcgaaacgctcaagactctgttggcctta gggtgtcatgtggcacagaccaacgtcaatgctgtggacgatctgaagaaagtcaaactg cccaaggagtatgtgatgtctaatgggtacaagccaacgccactggatctttctgaggtg aaactaacggccgggcaggaggttctggtggataaactggcagagaatgcacacaacgtg tgggccaaggacagaatcaaacagggatggacctatggaatacagcaggatgtgaaaagc aggcggaaccctcgcttggtgccctatgccctgctagacgagaggaccaagaagtccaac cgagacagcctgcgggaggccatcaggacactggtggggtacggctacaacatagacccc cccgaccaggaggcctgtcacgttgtggagaggcagagcatcgagaccatccgtttcttc cgcgtggagcagacgtatgccgtgaagaccgggaagtggtactttgagtttgaggcggtg accgggggggacatgagggtgggctgggccagacccggctgcagatccgactttgacctg ggcatggacgaccaggccttcgtcttcgacggattcaaggctcgccgtatgcacatgggc gcgacttccttcgggcgttcttggagcccaggagatgtggtgggctgcatgatcagcatg gaggacaagtcgatgatgttcaccctcaacggggaactgctcatcaccaacaagggatct gagctctgcttcattgactttgagactgaggacggttttatcccagtgtgttgcataacc cagtcccaggtgggtcgtatgaacctggggaaggacgccagcacctttaagtattacacc atgtgtggtctccaggagggctttgaaccctttgcggtcaacatgaacagagaggtcacc atgtggttcagcaaacgccttcctacctttgtcaatatccccaaggaccacctccacatt gaggtgaccaggatcgacgggacagttgataaccccccctgtctgaaagtgacccacaag acctttggaacccagcagagcaacagtgacatgttgtactgcagactcagcatgcctgtg gagttccacgcccgtgatgtcaacgctgaagagtctcagaaactcagtcagcctccgaag gaagacgattacggaagcatcacaacatacttccactcagtgagggtgttcgctggtcag gacccggcgtcggtgtgggtcggctgggtaaccccggactaccattacatcagcaagaac ttcagcctcaacaaaacacgcacggttactgtaaccctgggagacgaaagaggtcgcgtc cacgagagtgttcggagaagtaactgctacatggtctgtgccggagatgttgccagcgcg tcccactcctcatctcgttccaacgtcgacctggagattggctgtttcgttaacctggca acaggcttaatcgctttcactgccaacggcaaggagctggcaaccacctacgaggtggag tccaacaccaagctgttccctgctgtgtttgtccgtcccaccagccccaacctgttccag tttgagtttgtcaaaatcaagaacgccatgcccttgtcgtccgcgatcttcaagagcgag ctgcgcaacccggtgccccagtgcccgccgcgcctggacatccagaccatggtgtcggtg ctgtggagccgcatgcccaaccacttcctgacggtggagacggcccgggtctcggagagg cacggctgggtcgtccagtgtctggagcccctgcagatgctggctgttcatatacccgag gagaacaggtgtctagacatcctggagttatcggaagacgagggtctgagggcgtttcac taccacaccctgaagctctactgtgccctctgtgcactgggtaacactcgcgtggctcac gccctctgctctcacctcgaccaatcacagctgctctacaccatcaacaaccagtacctg tccggcatgctaagagagggcttctatgacgttctgattagcatccacctggagacagcc aaggatgcccgtctgatgatgaacaatgagtttattatccctgtcaccgatgagacacgc tccatcaagctgttcccagatgagtcaaagagacactccctgcctggcgtgggcctcagc acatctctgaaaccaaggctcaacttctcccctctgtccttcatcaccaccaagaaaaca cagcacctctacagcccccacatccccctggggatcctgaaggacaaggccatcagcatg ctgaccgaggctgtgcagggcggaggcagccacatccgggacccggtgggaggcagtgtg gagttccagttcgtccccatcctcaaactcatcggcaccctgctgatcatgggggtcctc accagcgaggaggtgcggctgattttgctcctcattgaccccaacgtgtttggagaccca cccgaggaggaggcgaaggtagaggaggcagtggcagtaggggagaaggaggacgtgagc agcaacgaggagaaggccgtggaggccggtgaggaggagaacaaggaggtcaagccacca gtgaagggactgctggagaagacactgcctgaatcggtcaagcgacagatgtgtgagctg ctccactacttctgcgactgtgaactgaagcagcgtatcgaggccattgtgtccttctca gacggtttcgtctccaagctgcagttcaaccagaagttcaggtacaacgagctgatgctg gccctcaacatgtccgctgccgtcaccgccaaaaagaccaaggagttcaggtctcctcct caagaacagatcaatatcctgttaaacttctctgctggggaggactgtccgtgtccagag gagattcgggaggagctgtacagcttccatgatgagctcagactgcactgcggaatccca gtggaggaggaggaggaagagcaggacaagtcaataaagggtcgtctgctggctctcctc tacaagattaaaggacctcccaagaaaaaagatgagcagcctacagaggaagaacaagct gctcccaccaacctgaaggagctgatctcccagaccatggccagctgggcccaggagtgc agtatccaggacccggaactggtccgcgtgatgttcagcctgctgagacgacagtacgac ggtgttggagcgctactgagagccttgaggaagagttacaccatcagtgccgcatcagta caggactgtgtcaacctgctggcttccctgggccagatcagatctctgctggcggttcgc atggggaaggaagaggagaaactgatgatagatggactgggagacatcatgaacaacaag gttttctatcagcaccccaacctgatgagggtcttgggaatgcacgagaccgtcatggag gtcatggtcaatgtgctgggaggagacaagtcccaggagatagccttccccaagatggtg gccagctgctgtcggttcctgtgttacttctgtcgtattagccgtcagaaccagaaggca atgtttgatcatctgagctacctactggagaacagctctgtcggactggcctccccggcc atgcggggctccacacccctggatgtggcggcctcttcggtgatggacaacaacagcctg gccctggccctggaagagcccgatctggaaaaggtggtgacctacctggcaggttgtggc ctgcagagctgtgctatgctcctagctaaaggctatcctgatatcggctggaacccaata gaaggagagagatacctgtccttccttcgctttgctgtcttttgcaatggtgagagtgtg gaggagaattcaaacgtggtggtgaagctgttaatcaggcgtccggagtgtttcggtccg gctctgagaggagaagggggtaacggtctgttggcggccatgttggaagccattaagata tctgaggaccctgctctggacctgccctctacagccaaagcccaacccgatgggtcaggg gaggatgaggaggaggaagaggtggcccacaccggaaacgccatcatgtctttctactcc gcccttattgacctgctgggacgctgcgccccggagatgcacctgatcaacaagggtaaa ggcgaagccctgcgcatccgggccatcctacggtccctggttccgaccactgatctagtg ggcattataagtatcccactgaaaatgcccactgtcaataaagacggtaccgtgaaggag cctgacatgtcagctagtttctgcccggaccacaaggcccctatggtgttgttcctggat cgtgtgtacggcgtggaggaccagaccttcctgcttcacctgttagaggtgggcttcctg ccagacctccgggcttctgcttccttggacacggatgtcctgagcaccactgagacagcc ctggccatgaacaggtacatcggctcggccgtgctgcccctcctcaccaggtgtgccgac cagttcgccggcaccgagcactacgccacgctcatagactccacgctgcacaccatctac cggctgtccaagggacgctcgctcaccaaggcccagagggactccatcgaggagtgcctg ctcgccatctgcaaacacttgcgtccctcgatgatgcagcagctgttgagacgcctggtc tttgatgttcccctgctgacggagtactgcaaaatgcccctcaggcttttgacagaacac tatgagcagagttggaagtactactgcatcccatctggaatgggcatctctggcatggcg tcagatgatgagctcctgctcaccaagaaactcttctggggaatattcgactcgctctca gccaagaggtttgaccctgacctgttcaagactgccatggcctgcctcagtgccattgcc ggagctgtgccacctgactacgtggacgccagccccagtgccaccctggagaagcaggtt tccgtggacgcgcatggaaactttgaccccaaacccatcaacacagccaacatctctctc cctgagaaactggactacattgccaacaagtttgcagagcagtcccacatcaagtggtct tctgagaaggtgacagcgggctggaaaacgggagacgttttggatgaagaggccaaaact caccctctgctcaagccttacaaatccctgagtgagaaggagaaggagtcgtaccgttgg ccagtgaaggaatctctcaagagcatgttggcaatgggctggaacattgagaggaccaaa gagggagaagccatgttaatcgagaaacaaatcaagatgtcggagtccactcaggataac gataatggattcatcccggaatcaccaatggacctgagcaacattactctgtccagagag ttgcagtccatggtggaggttgtggcggagaactatcacaacatttgggccaagaagaag aaaatcgagctggatggtaaaggaggcgggacccactccttgctggttccctatgacaca ctgacagctaaagagaagtaccgcgacagagagaaggcccaggatctctttaagtttctg cagatcaacggatacaccatcaccagaggcgtgaaggacatggagcaggactcgtcgtcc atggagaagaggtttgcctacacgttcctcaagaggctgctgaaatacgtggactcagct caggagttcattgcccacctagaggccatggccacgagcggaaagacggacaagtcaccc cacgaccagcaaatcaagttcttcgccaaggtcctgctccctctcatcgacacctacttc aagaatcacagcatgtacttcctgtccacgccctctaagaacctgagcagcagtggctac gcatctaacaaggagaaggagatggccactagcctgttctgtaagatggcagctcttgtc agacacaggatttccctctttggaagtgacacagggattatggtgagctgtctactcatc ctggctcattctctggatacaaggacggtgatgaagtcaggctcggagctggtgaaggct ggtgtgaggacgttcttcgagaacgcagccgaggatctggaaaagactctggagatgctg aagctcggaaagttcagccattcccgctcacagatgaaatgcttgtcccagaacatcagc tacgccaccactgccctgctgcccatcctcaccggcctgttcgaacacatcaccatgcac aaatttggagtccagctgctggtggatgatgtccagctgtcgtgctatcgcatcgtgacc tgtctctacacattgggcacagggaaatacatctacgtggagaggcacctgccggctcta ggggagtgtctggccaccctggtgggagcgatgcctgcggccttcctggagccggatctg aacgcccacaaccccctgtcggtcttcaacaccaagacaccccgcgagagggccatcctg agtatgccagactctgttgtggagatgtgtccagagatgccccgtctggacggcctcctg aaggacattaacgacatctcggagtctggtgcacggtacaccgagatgcctcaggtgatc gaggtgatcctgcccatgctgtgtacctacctgtcccactggtgggagaagggcccggag aactcggcgcccgacgcggcctgctgcaccaccgtctgttccaaccacctcagcatcatc ctggggaacatcctcaagatcctcaacaacaacctgggcatcgatgatgccccctggatg aagaggattgcagtgtactctcagccaatcatctgcaaggctgcggcggacctcttgaaa agtcactttctgcccactctggagaaactcagaaagaagacagtgaaggtggcagcagag gaggagctgctgaaggccgacattaaaggagatactcaggaggctgagctgctcatcctg gatgagtttgctgtcctctgcagagacctctatgccttctacccaatgctcatccgttat gtggacaataacaggtccagatggttgaaacggccaaatgctcagtccaatgagctattc aacatggtggctgagatctttatcctttggtgcaaatcacataacttcaaaagggaagag cagaattttgtggttcagaatgaaatcaacaacctatcttttctgactggagaaagtaag accaagatgtccaagtccggtggcgaccaggacaggaagcacaagaggcgacgcggggag ttgtactcggtccagacctccctgatcgttgctgccctgaagaagatgctccccatcggg ctgaacatgtgcacacccggagaccaggagctcatctccctggccaagacacgctacagc ctgaaagacacggatgatgaggtgaaggaccagctgcgtgccaaccttcaccttcgggac aagtctgatgacctggcagtgcagtggcagatgaacctgtataaagacgtggtggtggag agtgatgagcctacagaggcagacaacatcgttgacagagtacagagcatctctgctgcc atctaccacctggagcaggtggagcagcctctaaggatcaagaagtgtatcctgcagaag ctgctgtccaagcagcgcaaacgggccgtggtggcctgcttccgcatggctccgctctac aacctgcccaggcatcgttctattaacctcttcatgttgggctatcagagactgtggata gaggcagaggactactcctttgaggagaggctagttcaggacctggcaaaaacccaaatg aagatcgttgaagaggaggaagaggatgaggttgaggttcagccagatcctctgcatcag cttatccttcacttcagccacaatgctcttacagagagaagtttcttggaagaagatcct ttatatattgcttatgcagacatgatggcaaagagttgtgcagaggatgaagaagaaaat gaggaagaggctaaagagaagacattcgaggaaaaagagatggagaaacagaagatcttg taccagcaggccagacttcatgcacgcggggctgcagagatggtgctgcagatgatcagt gccagtaaaggtcgattaggtcctatggttacctgcaccctgaaactgggcatctccatt ctgaatggaggcaatgtgttggttcagcagaaaatgctggattacctgaaagaaaaaaga gacgctggctttttcaagagtttgtcaggactgatgcagtcatgcagtgtcctggacttg aatgcctttgagagacagaacaaagcagaaggtcttgggatggtgacagaggaaggatcc atcaagagtgagcagggtaccaaagttctcacaaatgatgacttcaccaaagatctcttc aggtttttgcaactgctctgtgaagggcacaatggggatttccaaaacttcctgagaaca caaacgggaaacacaacgacagtcaatattattatcagcactgtggactacctgctacgc cttcaggaatccatcagtgatttctactggtattattctgggaaagacattatagatgaa catggacaggagaacttctcaaaggccttggctgtggccaagcagatcttcaactcactc actgagtacatccagggtccatgtattgggaaccagcagagtctggcccacagcagactg tgggacgcggtggtgggattcctgcatgtgtttgccaatatgcagatgaagctatcccag gactccagccagattgagctgctgaaggagttgatggaccttcaaaaggacatggtggtg atgatgctgtcattgctagagggtaacgttgttaacggaactattgggaaacagatggtt gacacgttggtggagtcctccagcaacgtggagatgattctcaagttcttcgacatgttc ctcaagatcaaggacctgaccacctccgacaacttcagggagtacgaccccgataacaag ggagtcatctcaaagaaggaattccaaaagtccatggagaaccagaagcaatacacccag tcggagattgagttcctgctctcctgcgctgaggcagacgagaacgacatgtttaactac gaggagttcgtcgagaggttccacgagccagccaaggacattggcttcaatgttgccgtg ctgctgaccaacctttcagagcacatgcctcatgacccccgcctcgccaccttcctggaa ccggcagagagcgtcttgaactactttgagccatatctgggccgcatcgagatcatgggc ggcggcaagcgcattgagagggtctactttgagatcagtgagtcaagtcgtacgcagtgg gagaagccccaggtcaaagagtccaagagacagttcatcttcgacgtggtcaacgagggc ggagagagcgagaagatggagatgtttgtcaacttctgcgaagacaccatctttgagatg cagctggcctctcagatatcggagccggacgtggtggagcgcccagaggaggacgaggag gaggtgcacagcttctttgaagagcttgcggaggaacaggaagagagcgagcttgaggct tcctcagctttcaacatggcctgcgtctctgccaagaagaaattctccaaattcaagcag acgctgacttttaagaacctcaagaagaagtacaagaagttcaagaagctgagcataaag gagatgatccatgggttcttctccttcttctggatgatcttcacaggcttcttcaagggg atatacagcataatctttggatttttccatctcatctggtcatctatgtttggaggaggg cttgttgaaggagccaagaatatgaaggtgacagacatactgggcaacatgccggacccc acacagttcggcatccacggcgatgtgttagagacggaaaaggcggaggtgggagattcg gtgtcgggcgggacagaccaggccattgtgccagtggacaaggcagagcaggacatactg atggagttgattaacccggcgccaaaaaaaggagaagggttaaaacatgtcgatcctgga ctaggcgatatggctgagagtcagactgtggagaagaagaatttgaccagcactttcgag aagaagaaggccgccactgccgctgaagtcaaggaatctgagccagagaaagcagacact gagaagaaggagaaggaagacaaggcgatggtggcggagcttaaagaggcagtggctgag gagaaacctgtccccaagtcgagaaacggccaagcaaaggaagctcctacttccttcttt gccagcttctttgttgggctggaggtctatcagaccaagatgctgaacacactggctcgc aacttctacaacatgcgtttcctggctctgtttgtggcatttgccatcaacttcattcta ctgttctacagggtaactggtgatggttctgataatgatgaggatgactcctggactagt tctgatgacgaggaggaaggtgacgatgagtactttgtcctggaggagagtacaggctac atggcccctatgctgtgtttcctggcgttattccacactgctctttccacactctgtctg gttggttactacttcctgaaggtgcccttggtggtgtttaagagggagaaagggattgcc aggaagttggagtttgacggactctacatcacagagcagccgtcggatgatgacatcaca ggacagtgggaccgtctagtcattaacacaccgtcctttcccaataactactgggataag ttcatcaaacggaaggtgatcaacaagtatggtgatatgtacggagctgtgcgtatagct gaactgttgggtctggacaagagtgctctggacttcgacccgacccaggagaccgtggca gaggagggttctctcgtgtcctggttgagctcaatcgacaccaaataccacatctggaag atgggcgtggtgctgactgataactccttcctctatctgatctggtacgccaccatgtca atcctggggcacttcaacaacttcttcttcgccgcccatcttctggacatcgccatgggc ttcaagaccctgagaaccatcttgtcctcagtcactcacaatggaaaacagttggtgctg actgtgggtcttctagcagtggtggtgtatctttacactgttgtggccttcaacttcttc aggaagttctacaacaagagcgaggatgaggctgcccccgacatgaagtgtgacgacatg atgacttgctatctgttccacctgtatgccggggtgagggctggcggtgggatcggcgat gagctggaggatccggcaggtgacccttatgagctgtggcgtatcctgtttgacatcacc ttcttcttcttcgtcatcgtcatcctcttggccatcattcagggtctgattattgacgcg tttggggaactgagagatcagcaggaacaggtgaaggaagacatggagacgaaatgcttc atctgtggtatcggaaacgactacttcgacacgacaccgcacggctttgagacccacacc ttacaggagcacaacctggccaactatctgttcttcctgatgtaccttatcaacaaggac gagacggaacacactggtcaggagtcatatgtgtggaagatgtaccaggagagatgctgg gacttcttccctgctggtgattgtttcaggaagcaatatgaagacctgctcgggtag

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