Epinephelus lanceolatus (giant grouper): 117270695 Help Entry 117270695         CDS       T07331                                  Symbol ryr3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism ely  Epinephelus lanceolatus (giant grouper) Pathway ely04020   Calcium signaling pathway ely04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:ely00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     117270695 (ryr3)    04020 Calcium signaling pathway     117270695 (ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:ely04040]     117270695 (ryr3) Ion channels [BR:ely04040]  Voltage-gated cation channels   Ryanodine receptor    117270695 (ryr3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Med16_bridge Motif Other DBs NCBI-GeneID:  117270695 NCBI-ProteinID:  XP_033504325 LinkDB All DBs Position 18:complement(25910884..26085908) Genome browser AA seq 4777 aa AA seqDB search MLAKTGQNSEGSADHEKWAGQGGGHRTLLYGHAILLRHSFSDMYLTCLKTSRSLTDKLSF DVGLQEDSIGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSTERYLHLSISNGNIQVDA SFMQTLWNVQPTCSSGSMAVGYLRGGHVMRLCHGHDESLTIPGADKNEEEQRIVNYEAGK GASRARSLWRLEPLRISWSGSHIRWGQAFRIRHLSTGHYLALTEDRGLVLQDREKSDTKA TAFCFRPSKEKSDSGPKRDIDGMGVPEIKYGDSVCFVMHVATGLWLSYLAPDAKSSRLGP LKRRACLHSEGHMDDGLILQRCQHEESRAARIIRNTTFLFANFIKALDSIGEGESSAVAG YVEEVLQTLNDLIEYFQQPDSELEHEEKQSLLRSLIKRQDLFKEEGMLALLSKCIDRMNL YNSAAHFGEVAGEEAGAAWKDILNLLYELLAALIRGNRNNCTQFSRKLDWLVSKLERLES SSGILEVLHCILIESPEALHIIQKAHIKSIISLLYKHGRNHKILDVLCSLCVCNGVAVRA NQNLICDNLLPKRDLLLQTRLVNDVQSMRPNIFLGVAEGSAQYKKWYFELVIDQVDHFVT GEPTHLRVGWANTQGYAPYPGGGEGWGGNGVGDDLYSYSFDGLHLWSGRIPRAVASINQH LLNSDDVVSCCLDLGAPSMSFRINGQPVQGMFEDFNTEGFFFPVVSFSAGVKVRFLLGGR HGDFKFLPPAGYSPCYEALLPKEKMHVEAVKEYKRDHEGVRDLLGTTKFLSQASFIPTPV DTSQIVLPPHLDNVRDKLAENIHELWGMNKIELGWTYGKVRDDNKRQHPCLVDFAKLPET ERNYNVQMSSETLKTLLALGCHVAQVNVHAEDDLKKIKLPKDYVMSNGYKPAPLELSDVK LNAGQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKSRRNPRLVPYALLDERTKKSNR DSLREAIRTMVGYGYDIDPPDQEAVHVVDDQSIETIRFFRVEQTYAVKTGKWYFEFEALS GGDMRVGWARPGCRPDVELGTDDQAFVFDGFRGQRMHAGSRYFGHPWKKGDVVGCMINME DKSMIFTLNGELLITSKGSELCFADFETEDGFIPVCSLGMSQTGHMNLGKDASTFKYYTM CGLQEGFEPFGVNMNREITMWFSKRLPTFVNIPEDHMHIEVTRIDGTVDSPPCLKVTHKT FGTQNSNNDMTYCRLSMPVEFYSTDKILDESLKLSQPPKEDGSIDYGSITTYYHSVRVFA GQDPASVWVGWVTPDFHYYSKNFCLSKMRTVTVTLGDERGRVHESVQRSNCYMVCGADAA GPTSSSHSNSDLEIGCLIDLATGLVSFTANGKEMSTTYQVEPNTKLFPAVFVRPTSANLF QFEFVKIKDAMPLSSAIFKSEHRNPVPQCPPRLDVQTIVAVLWSRMPNTFLNVETARVSE RHGWVVQCLEPLQMLAVHIPEENRCLDIMELSEHEDLRKFHYHTLKLYCALCALGNTRVG HALCSHLDQSQLLYTIDNQYLSGMLREGFYNVLISIHLETAKEARLMMNNEFIIPVTEET RSIKLFPDESKRHSLPGVGLSTSLKPRVNFSAVGIIGTKRQQYLYSPQIPLGILKEKAIS MLTEAVQGGGTHIRDPVGGSVEYQFVPILKLIGTLLIMGVLTSEEVRLILLLIDPNVFGE AKEGEEAKGDEVAVAGEKEEVSKNEEKAVEAGEEETKESKMPAKGLLEKSLPESVKRQMC ELLHYFCDCELKHRIESIVSFSDNFVSKLQFNQKFRYNELMLALNMSAAVTAKKTKEFRS PPQEQINILLNFSAGEDCPCPEDIQEELNSFHEELRLHCGIPVEEEEEEQDTSIKGRLLA LLYKIKGPPQKTEEEPTEKEQAAPTNLKELISQTITSWAQESHIQDPELVRVMFSLLRRQ YDGIGELLRAMKKSYTISAASVQDAINLLASLGQIRSLLSVRMGKEEEKLMIDGLGDIMN NKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKSQEIAFPKMVASCCRFLCYFCRISRQNQ KAMFDHLSYLLENSSVGLASEAMRGSTPLDVAASSVMDNNGLALALEEPDLEKVVTYLAG CGLQSCAMLVAKGYPDLGWNPIEGERYLSFLRFVVFCNGESVEENANVVVKLLIRRPECF GPALRGEGGQGLLAAMKEAIKISEDPALDLPSTPAVVNTGSGEEEEEVIHMGNAIMSFYS ALIDLLGRCAPEMHLINAGKGEALRIRAILRSLVPTTDLVGIISIPLKMPVLNKDGTVTE PDMSASFCPDHKAPMVLFLERVYGIEDQSFLLQMLEVGFLPDLQASASIDTELLSTSETA LAMNRYIGSALLPLLTRCAALFSNTEHYAQLIDSTLQTIYRLSKGRSLTKAQRDAIEECL LAICKHLRPSMMQQLLRRLVFDVPMLNEYCKIPIRLLTNHYEQNWKYYCLPSGMGSYGTA SEEELLLTKKLFWGIFDSVAQKKYDPDLFKMAMSCLCAIAGALPPDFIDATLGATLEKQT SVDAQGNFDPKPINTANISLPEKLEYIANKYAEHSHDKWSSEKVSAGWKHGDSLDEQAKT HPLLKPYKGLSEKERETYRWPVRESLKSMLSMGWNIERTKEGEAMFQQRESEKQRKTSES QSNGFSPAPMDLHNVTLSRELQGMVEVVAENYHNIWAKKKKTELVSKGGGTHPLLVPYDT LTAKEKYRDREKAQELFKFLQISGYAIIRGLKDMEQDSSSMDKRFSYKFLKRLLKYVDSA QEFIAHLEAMATSGKTDKSPHDQEIKFFAKVLLPVIDQTFKNHHLYFLSTPSKNLSSCGC ASNKEKEMVTSLFCKLAALVRHRISLFGSDSAMMVSCLHILTHSLDTRTVMKSGSELVKA GVRTFFENAAEDLEKLLEMLKLGKFMQSRAQMKSVTQSINYVTVALLPILTALFEHITTY GFGVDLLLDDVQLSCYRFLTCLYSLGTGKNIFVERHLPAIGESLATLVAAMPVAFLEPHL NAHNPLSVFNTKTPRERAILSMPDTVEEMCPELPRLDRLLKDVSDVSESGARYSEMPQVI EVILPMLCNYLSYWWEKGPENSPPDAHCCTMVTSEHLSIILGNILKILNNNLGIDDAPWM KRIAVYSQPIICKAGADLLRTHFLPTLDKLKKKTVKVVAEEELLKADGKSDNQEAELQIL DEFAVLCRDLYAFYPMLIRYVDNNRSRWLKEPDANSTQLFRMVAEIFILWCKSHNFKREE QNFVVQNEINNLGFLTGEGKAKMSKSGGDQERKHKRRRGEYYSVQTSLIVAALKKMLPIG LNMCTPGDQELISLAKIRYSLKDTDDEVKEHLRQNFHLQDKSDDPAVQWQLNLYKDVVVK SEEPANVEHSVDRVQCISAAVFHLEQVEQPLRNKKLVWHKLLSKQRKRAVVACFRMAPLY NLPRHRAINLFIPAYQRLWIEAEEYSFEEKLVQDLAKTPMKIVEEEEEEVAEIQPDPLHQ LILHFSHNALTERSCLEEDPLYIAYADMMAKSCAEDEEEEEEEGKEKTFEEKEMEKQKIL YQQARLHARGAAEMVLQMISASKGRLGPMVTCTLKLGIAILNGGNVQVQQKMLDYLKEKR DAGFFKSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSIHTQRGSKVLQNDEFTKDLF RFLQLLCEGHNGDFQNFLRTQTGNTTTVNIIISTVDYLLRLQESISDFYWYYSGKDVIDE TGKVNFSKALDVAKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQ DASQIELLKELMDLQKDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSNNVEMILKFFDMF LKLKDLTTSDSFREYDPDCKGIISKKEFQKSMESQKQYIQSEIEFLLSCAEADENDMFNY KEFVERFHEPAKEIGFNVAVLLTNLSEHMPHDARLATFLDLAESVLSYFEPYLGRIEIMG SAKRIERVYFEISESSREQWEKPQVKESKRQFIFDVVNEGTESEKMEMFVNFCEDTIFEM QLASQISEPDAVEHPEEEAEEEAHSILDELAEEEEGALESASAFTTACRSVKKKVASVRQ IFSMKNVRKQFKKMKNLSIREIITSFVSFFWMLFTGFFKGIYGLIFGFFHVIWSSMFGGG LVEGAKNMKVTDILGNMPDPTQFGIHGDVIEGEKVEAIESSGSLDTAMAPAGDLAEVDAM LEMLSNPKKEGGKHSEPGLGDVSELSAETSSADQKKKTASKPAETPESEPEKADTENQEK EDKPKTEEEAKEPVAEEKPKARSSQPKEAAPGSMWSIFAVLDVYVTKLLNYLARNFYNLR FLALFVCFAINFILLFYKVTGETDEEVDEAMTWGGEEDDDGENTLFDMDEFVLQESTGYM LPTLRFLAVFHTVISLICLLGYYFLKVPLVVFKREKEIARKLEFDGLYITEQPSDEDIKG QWDRLVINTPSFPNNYWDKFIKRKVINKYGDLYGAERIAELLGLDKSALDFDPTVETVEK EASLLSWLSSVDTKYHIWKMGVVLTDNYFLYLIWYTTMSIFGHFNNFFFAAHLLDIAMGF KTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMM TCYLFHMYVGVRAGGGIGDELEDPAGDPYELYRILFDITFFFFVIVILLAIIQGLIIDAF GELRDQQEQVKEDMETKCFICGIGNDYFDRTPHGFETHTLQEHNLANYLFFLMYLINKDE TEHTGQESFVWKMYQERCWDFFPTGDCFRKQYEDQLG NT seq 14334 nt NT seq  +upstreamnt  +downstreamnt atgctggctaaaactgggcagaacagcgaagggagtgctgaccatgaaaaatgggcgggt caggggggtggacaccggaccctgctctacggtcatgccatcctccttcgccactcgttt agtgatatgtacctgacctgtttgaagacatcgaggtctctgacagacaagctgtcattt gatgtcggactacaagaagattcaataggagaggcctgctggtggaccattcaccctgcg tccaagcagagatccgagggagagaaagtccgcattggagatgacctgatcctagtcagt gtgtcgacagagagatacctgcacctctctatctccaatggcaacatccaggtggatgcg tccttcatgcagaccctgtggaacgtccagcctacctgctcttcaggcagcatggctgta gggtatttgaggggtggacatgtgatgcgtctttgtcatgggcatgatgagagcttgacc atccctggagcagacaagaatgaggaggagcagaggatagtcaactatgaagcgggtaag ggagcatcaagggcccgctcactttggagactggagcctctcaggatcagctggagcggt agccacatccgttggggtcaggccttccgaatacgccacctctctactggccattacctg gccctgactgaggaccgcggactggtcctgcaggacagggagaagtccgacaccaaggct accgctttttgcttcaggccctccaaggaaaagagtgattcgggcccaaagagggacatt gatggcatgggagtgccagagatcaagtacggggactctgtgtgcttcgtcatgcacgtc gcgacgggactgtggctgtcttacctggcacctgatgccaaatcgtctcgcctaggacct ctgaaaagaagggcctgcctgcattctgagggccacatggatgatgggcttatcctgcag cgctgtcagcatgaggagtctcgggctgctcgcatcatccgcaacaccacgttcctcttc gccaactttataaaggctttggacagcattggcgagggcgagtcctcagcagtggccggg tacgttgaagaggtgctgcagacgctgaacgacttgatcgagtacttccaacagcccgat tcggagcttgagcacgaggagaaacagtctctcctccgttcactcatcaaacgtcaagac ctcttcaaagaggagggcatgctggccctcctgtccaaatgcatcgaccggatgaacctg tacaacagcgctgcccacttcggagaggtagctggggaggaggcgggagcagcgtggaag gacattctcaacctcctctatgaactcttggctgcactgattcgtgggaacaggaacaac tgcacccagttttcccgcaaattggactggttggtcagcaaactggagagactggaatct tcatcagggatcctggaagtcctccactgtatcttgatagaaagtccagaggctctgcac atcattcagaaagctcacattaaatccataatctctctgctctacaaacacggacgcaac cacaagattctggatgtcctgtgttccctctgtgtttgtaatggggtggcagtgagagcc aatcagaatctgatctgtgacaacctgcttcccaagagggacctgctgcttcagactcga ctggtcaatgatgttcagagcatgcggccaaacatcttcctgggcgtggctgaaggttca gctcagtataagaagtggtattttgagcttgtgatcgaccaggtagaccactttgtaact ggcgagccgactcacctgagggtcggctgggccaatacccaaggctacgctccgtacccc ggtggaggagagggatggggtggcaacggtgtcggtgatgacctgtactcttacagcttt gatggacttcatctctggtcaggccgaatcccgagggccgtggcctccattaaccagcac ctgctgaactcagacgatgtggtcagctgctgtctggatttgggcgctcccagcatgtcc ttcaggatcaacgggcagcctgtccagggcatgttcgaggacttcaacaccgaaggattc ttcttccccgttgtcagcttctctgcaggtgtcaaggtccgtttcctgttgggtggacgc cacggagatttcaagttcctgcctcccgctggttactcaccgtgctacgaggcactgttg cccaaagagaagatgcatgtagaggccgtgaaggagtacaagagggaccatgagggggtt cgtgacctgctgggaaccaccaagttcctctctcaggcctccttcatccccactcctgtt gacaccagccagattgttcttccccctcacctggacaatgtccgggacaagctggcagaa aacatccacgaactgtgggggatgaacaagatcgaactgggctggacgtatggcaaggtt cgggatgacaacaagaggcagcacccttgccttgtggatttcgccaagctgcctgaaact gaaaggaactacaacgtgcagatgtctagtgaaacacttaagaccctgttggctcttgga tgccatgttgcccaggtcaatgtgcacgctgaggacgatctgaagaaaattaaacttccc aaagactacgtgatgtctaatggttataagcctgcgccactggaactctctgacgtgaag ctgaatgcaggtcaggaggttctagttgataaactggccgagaatgcacataacgtgtgg gccaaagacagaattaaacaaggatggacctatggcatccagcaggatttgaagagcagg cgtaatccccgcctggtgccatatgctttacttgacgagcgcacaaagaagtctaacaga gacagtctgagagaggccatcaggaccatggttggatatggatatgacatcgacccccca gaccaggaggctgtccatgtggtggacgatcagagcatcgagaccatccgcttcttccgc gtggagcagacatatgcagtgaagacaggaaagtggtactttgagtttgaggccctgagt ggaggagatatgagggtcggctgggccagaccaggctgcaggcctgatgtggaactgggg acggatgaccaggctttcgtctttgatggattcaggggtcaacgtatgcatgcaggcagc cgctactttgggcacccttggaaaaagggtgacgtggtcggttgcatgatcaacatggag gacaaatccatgattttcaccctgaacggagagctcttgatcaccagcaagggctctgag ctttgcttcgctgactttgagaccgaggacggtttcatccctgtgtgcagtctgggcatg tctcagactggacacatgaacctgggcaaggacgccagcacttttaagtactacaccatg tgtggtctccaggaaggcttcgagcccttcggcgtcaacatgaacagagagatcaccatg tggttcagcaagcgccttcccacctttgtcaacatacccgaagaccacatgcatattgag gtgacgaggatcgatggaacagtagacagccctccctgcctcaaggtcacccacaagacg tttggcacacagaacagcaacaatgacatgacttactgtagactgagcatgcccgtggag ttctactccacagacaagatactggatgagtcactgaaactcagccaacctccaaaagaa gatggaagtattgactatggaagcatcacaacttactaccactcagtgagagtatttgct ggacaggaccctgcgtcagtgtgggtgggctgggtcacgccggactttcattactacagc aagaacttttgcctcagcaagatgcgaacagtcactgtcaccctgggagatgagaggggc cgggtccatgagagcgtccagaggagcaactgctacatggtgtgtggagctgacgcagcc gggccgacttcctccagccactccaactctgatctggagatcggctgtctgatcgacctg gccactggccttgtgtccttcactgccaatggcaaggagatgtccacaacttaccaggtg gagccaaataccaaactgttcccagctgtgtttgtacgccctaccagtgcaaacctcttc cagtttgaatttgtcaagatcaaggatgcgatgccgctctcgtctgccatctttaagagc gagcacaggaacccggtgccacaatgcccgccacgactggacgtgcaaaccatcgtggcc gtgttgtggagccggatgccaaacaccttcctcaatgtggagactgctcgggtcagcgag aggcacggctgggtggtgcagtgtctggaaccactgcagatgttggctgtgcatatacct gaggagaacaggtgtttggacatcatggagttatcagagcatgaagacctgaggaagttc cactaccacacactgaagctgtactgtgccctctgtgccctgggaaacacacgtgttggc catgccctctgcagccatttggaccaatcacagctcctctacaccatcgacaaccagtac ctctctggcatgctgagagagggcttctacaatgtcctcatcagcatccatcttgagact gcaaaggaggctcgcctaatgatgaacaacgagttcatcatccctgtgacggaggagact cgctccatcaagctgttccctgatgagtctaagcggcactcactgcccggcgtgggcctg agcacctccctcaaacctcgggtcaacttctctgctgtcggcatcatcggcacaaagcgg cagcagtacctctacagcccccagatccctctgggcattctgaaggagaaagccatcagc atgctcactgaggctgtgcagggcggaggcacgcacatccgagacccggtaggcggcagc gtggagtaccagtttgtccccatcctgaagctgattggaacgctgttaatcatgggagtc ctaaccagtgaggaggtgaggctgattctcctcctgattgaccccaacgtgttcggagag gccaaggaaggcgaggaagccaagggagatgaagtggccgtggcgggggagaaggaggaa gtgagcaagaacgaggaaaaggctgtggaggccggagaggaggagacaaaggagagtaaa atgcctgctaaaggtctgctggagaagtcgctgcccgagtctgtcaaacgccagatgtgt gagctgctgcactacttctgcgactgcgagctcaagcaccgcatcgaatccattgtctcc ttttccgacaacttcgtgtccaagctgcagttcaaccagaagttccgctacaacgagctg atgctggcgctcaacatgtcagccgccgtcactgccaagaagactaaagagttccgttca cccccacaggagcagatcaacatcctgttgaatttcagtgcaggagaggactgcccctgt cctgaggacatccaggaggaactcaactccttccatgaagaattgcgactgcactgcgga attcctgtggaggaggaagaagaagagcaggacacttcaataaaaggccgtctcctcgct ttactgtacaagatcaaaggtccacctcagaagaccgaggaggaacccacagagaaggaa caggctgctcccaccaacctgaaggagctgatctcccagaccataaccagctgggcccag gagtctcacatccaggacccagagttggtcagagtgatgttcagcctgctcaggaggcag tatgacggcatcggagagctgctccgggccatgaagaaatcctacaccatcagcgccgcg tccgtgcaggatgccattaacctgttggcatcactgggtcaaatcaggtctctgctgtca gtccgaatgggcaaggaggaggagaaactcatgattgatggactcggtgacatcatgaat aacaaggtcttctaccaacatcccaacctgatgagagtgctgggcatgcacgagactgtc atggaggtcatggtcaatgtgctgggaggagacaagtcacaggagattgccttccccaag atggtggccagctgttgtcgtttcctgtgctacttctgtcgtatcagccgccagaaccag aaagccatgtttgaccacctgagctacctgctggagaatagcagtgtcgggctggcctct gaagctatgcggggctccactccgctggatgttgcagcatcttcagtgatggacaacaac ggcctggctctggctctggaggagcctgatctagagaaggtggtgacatacctggcaggc tgtggtcttcagagttgtgctatgctggtagcaaagggttatccagacctcggctggaac cctatagagggagagcgttacctgtctttcctgaggttcgtcgtcttctgcaatggtgag agtgtagaagaaaatgccaatgtggtggtgaagctgctgattagacgtccagagtgtttc ggtcctgccctgaggggagagggtggtcagggtctgctggccgccatgaaggaggccatc aagatatctgaagatcctgccctggacctacccagtaccccagctgtggtcaatactggg tctggtgaggaagaagaagaagtcattcacatgggcaacgccatcatgtccttctactca gctcttattgacctgttgggccgctgcgctccagagatgcatcttatcaatgcaggtaaa ggagaggcgctgcgtatccgagccatcctgcgctctctggttcccacgacagacctggtg ggcatcatcagcatccccctcaaaatgcctgtgctcaataaagatggcacagtgacagaa cccgacatgtcagcctctttctgtccggaccacaaggcccccatggtgctcttcctggaa agagtctatggcattgaggaccagagcttcttgctccagatgttggaggttggcttcttg cctgacctccaagcatctgcgtctattgatactgagctgttgagcaccagtgagacagca ctggccatgaacagatacatcggctcagccctgttgcctctgctcactcgctgcgccgct ctctttagcaacacagagcactacgcacagctgattgactccacactgcagactatctac aggctgtccaaaggacgctcactcaccaaggcccagagagacgccatcgaggagtgtctg ctggctatctgcaagcacctgcgtccctccatgatgcagcagctgctcagacggctggtg ttcgacgttcccatgctcaatgaatactgcaagatacctatccggctcctgaccaaccac tatgagcagaactggaagtattactgcctgccttctggtatgggcagctacggcacagcc tccgaggaggagctccttctaaccaagaaactcttctggggaatctttgactctgttgct cagaagaagtacgatcctgaccttttcaaaatggccatgtcatgcctgtgtgccattgct ggagccttgcctccagactttattgatgccactcttggagcaacactggagaaacagaca tcagtggatgcacagggcaactttgatcccaaacccatcaacactgccaatatctccctt cctgaaaaacttgagtacattgccaataaatatgcagagcattcccatgacaagtggtcc tcagagaaggtgtcagcaggttggaaacatggagacagcttggatgagcaggccaaaact catccactgctgaagccttacaaagggctgagtgaaaaggagagagaaacataccgctgg ccagtgagggagtctctgaagagcatgctgtctatgggctggaacattgagaggaccaag gagggagaagccatgttccagcaacgagagagtgaaaaacaacgaaagacctctgagtct cagagtaatggattcagtcctgctccaatggatttacacaatgtcacattgtcaagagag ttacagggcatggtggaggtggttgcagaaaactaccacaacatctgggccaagaagaag aagactgaactcgtcagcaaaggaggagggacccacccgctgctggttccctatgatacc ctgactgctaaggagaagtacagagacagagagaaggcccaggagctcttcaagtttttg caaatcagcggctacgccatcataagaggtctgaaggacatggagcaggactcatcatcc atggataaacgtttttcctacaagttcctcaaaaggctgctgaagtacgtcgactctgcc caggagttcatcgctcatcttgaggctatggccaccagtgggaagacagacaaatcacct catgaccaggaaatcaagttctttgctaaggtgttgcttcctgtgatagatcaaactttt aagaaccaccatctctacttcctgtccacacccagcaagaacctgagcagctgtggctgt gcctccaacaaagagaaggagatggtcaccagcttgttctgtaagctggcagctcttgtc agacacaggatttctctctttggaagtgactctgccatgatggtgagctgtctgcacatc ctcacccactcacttgacacaagaacggtgatgaaatctggctcagagctggtcaaagcc ggggttcggactttctttgagaacgcagcagaggacctggagaagctgctggagatgctt aaactggggaagttcatgcagtcccgtgcccagatgaagagcgtcacccagagcatcaac tatgtgaccgtggcactgctgcccatcctcaccgccctgtttgagcacatcacaacatat gggtttggagtggaccttctgttggatgatgtccagctgtcctgctacagattccttacc tgtttgtactctctgggaacaggaaagaacatctttgtggaaaggcatcttccagcaata ggggagagcctggcaactctggtggcagccatgcctgtggcattcctggagccccactta aacgcccacaacccactctctgtcttcaacaccaagaccccaagagagagagccatcctg agtatgccggacacagtggaggagatgtgtccggagttgccgcgccttgacagactgctg aaagatgtcagcgatgtgtcagagtctggtgctcgctacagtgaaatgccacaggtcatt gaggtgatcctccccatgctttgtaactatctgtcctactggtgggagaaaggtccggag aattcacctccagatgcccactgctgcactatggtaacttctgaacacctcagcatcatc ctgggaaacatcctcaagatcctcaacaacaacctgggcatcgatgacgccccctggatg aaaaggattgcagtctactctcagccaatcatctgcaaggctggagcagatctgctgaga acccacttcctgccgacactggacaaactgaagaagaagacagtgaaggttgtggctgaa gaggagctgctgaaggcagacggtaaaagtgacaaccaggaggccgagctgcaaatccta gatgagtttgctgtgctctgcagagacctctacgccttctaccccatgcttatccgttat gtggacaacaacaggtccaggtggctgaaggagcccgatgcaaactccactcagctcttc aggatggtggctgagatcttcatcctctggtgcaagtcccacaactttaagcgtgaggag caaaactttgtggttcagaatgagatcaacaacttgggcttcctgaccggtgagggcaaa gcgaagatgtccaagtcagggggggaccaggagaggaaacacaagcgccgtcgaggcgag tattactccgtccagacgtccctgatcgtagctgccctgaaaaagatgctgcccatcggc ctcaacatgtgcaccccaggagaccaggagctcatctcccttgccaagatacgctacagt ctgaaagacacagatgatgaggtgaaggagcacttgcgtcaaaatttccacctccaggac aagtctgatgacccagctgtccagtggcagctgaacctttacaaagacgtggtggtgaag agtgaggaacccgcaaatgtagaacactcagtggacagagtgcagtgcatctcagctgca gtcttccacctggagcaggtggagcagcctctgagaaataaaaagttggtgtggcataag ctgctctccaaacagcgcaagcgtgcggttgtggcttgtttccgcatggctccactctac aatctacccaggcatcgcgctatcaacctcttcatcccggcctatcagagactttggata gaggcagaggagtactcctttgaggagaagctagttcaggatctggcaaaaaccccgatg aaaattgtggaggaggaggaagaggaggtggctgagatccagccagaccctctccaccaa ctcatcctccacttcagccacaacgctctgacagaaagaagttgcttggaagaggatcct ttgtatattgcgtatgcagacatgatggcaaagagctgtgcagaggatgaggaggaagaa gaggaggaagggaaagaaaagacttttgaggaaaaggagatggaaaagcagaagatcctg tatcagcaggcgaggctgcacgcccgtggggccgccgagatggtgctgcaaatgatcagt gcgagtaaaggtcgtctgggccccatggtgacctgcaccctcaaactgggaatcgccatc ttaaatggaggcaatgtgcaagttcagcagaaaatgcttgattacctgaaagagaaaaga gatgcaggctttttcaagagtctctcgggactgatgcagtcttgcagtgtcttggacttg aatgcatttgagaggcagaacaaagcagaaggacttggcatggtgacagaggaaggctca atccacactcagcggggttccaaggtgctacagaatgatgagtttactaaagatctgttc cggtttttgcaacttctgtgcgaggggcacaatggagatttccagaatttcctgagaacc caaactggaaacacaaccacagtcaacatcattatcagcactgtggactatctgctacgg cttcaggaatctatcagtgacttctactggtattactccggcaaagatgtcattgatgag actggaaaagtcaacttctccaaagctttagacgttgccaagcagatattcaactcactg actgagtatattcagggcccgtgtattgggaaccagcagagtttagctcacagcagactg tgggatgcagttgtaggcttcttgcatgtatttgccaacatgcaaatgaagctgtctcag gatgccagtcagattgagctgttgaaggagctgatggatttacagaaggacatggttgtc atgttgctgtctctgctagagggtaatgtggtgaatggaacaattggaaagcagatggtt gacaccctggtggagtcgtctaacaatgtggagatgatcctcaagttctttgatatgttc cttaaactgaaggacctgacgacctctgacagcttcagagagtatgaccccgactgtaaa ggcattatttcaaagaaggagttccagaagtcaatggagagccagaagcagtacattcag tctgagatagaattcctgctctcgtgcgcagaggccgatgagaatgacatgttcaactac aaggagtttgtagagcggttccacgagccggccaaagaaatcggcttcaatgtggcagtg cttctgaccaacctgtctgaacacatgccacacgacgccagactcgccaccttcttagac ctagcagagagcgtactcagctactttgagccttacctgggtcgcattgaaatcatgggc agcgcaaagcggattgagagggtgtactttgagatcagcgagtcgagccgggagcagtgg gagaagccgcaggtcaaagagtccaagcgccagttcatctttgacgtggtcaatgagggc acggagagcgagaagatggagatgtttgtgaatttctgtgaggacaccatttttgagatg cagctagcctcacagatctctgagccagatgcagttgagcatcctgaggaggaggctgag gaagaagcacacagtatcctggacgagttggctgaagaggaagagggcgccctggagtct gcctcagcctttaccaccgcatgccgctcagtcaagaaaaaggtcgcctccgtccgccaa atcttttctatgaaaaacgtgcgtaagcagttcaagaaaatgaagaacctgagcatcagg gagattatcaccagcttcgtctccttcttctggatgctcttcaccggcttcttcaaggga atctacggcctcatctttgggttcttccacgtcatctggtcctccatgtttggcggtggc ctggttgaaggagccaagaacatgaaggtgacagacatcctcggaaacatgcctgaccca actcagtttggtatccacggagatgtgattgaaggagagaaagtggaggctatagagtca tcaggaagcttagacacagccatggcaccagcaggcgacctagcagaggtcgacgcgatg ttggagatgctgtcgaatcccaagaaggagggaggaaaacattcggagccgggtctgggt gatgtttctgagttgagtgcagagacctccagtgctgatcagaagaagaaaactgcatcc aagcctgctgaaacccccgagagcgaaccagagaaagcagacacagagaaccaggagaag gaggacaagccaaagacggaggaggaggcaaaggagccagtggccgaggagaagcccaaa gccagatcgagccaacctaaagaggcggcgccgggctccatgtggagtatttttgccgtt ttggatgtctatgtgaccaaactgctgaactacttggctcgtaacttctacaacctgcgt ttcctggctctgtttgtgtgctttgccatcaacttcattcttctcttctacaaggtcact ggtgaaactgatgaagaagtagatgaggcaatgacctggggtggcgaggaggatgatgat ggtgagaacacactcttcgacatggatgagtttgtcctgcaggagagcaccggctacatg ttaccaactctgcgcttcctggctgtattccacaccgtcatctcactcatctgtctgtta ggatactacttcctaaaggttcctttggtggtattcaagagggagaaggagatcgccagg aagcttgaatttgacggtctctacatcaccgaacagccgtctgatgaggacatcaagggc cagtgggatcggcttgtcatcaacaccccgtctttccccaacaactactgggacaagttt ataaagcgcaaggtgatcaacaaatacggtgacctgtacggagctgagcgcatcgctgaa ctcttgggcctggataagagcgctctggactttgaccccacagtggagactgtggagaag gaagcttccctgctgtcctggctgagctccgttgatacaaagtaccacatctggaaaatg ggcgtggttctaactgacaactacttcctgtatctgatctggtacactaccatgtccatt ttcggacacttcaacaacttcttctttgctgcccatctgctggacattgccatgggcttc aagaccctccgcactatcctgtcttctgtcactcacaacggcaagcagctggtgctgact gtgggtctgctggctgtggtcgtctatctctacaccgtggtggcctttaacttcttcaga aagttctacaataagagcgaggacgaggacgagcccgacatgaagtgtgatgatatgatg acgtgctatttgttccacatgtacgtgggtgtgagagccggaggtggtattggagacgag ttggaggacccagctggagacccctacgagctctaccgcatcctgtttgacatcaccttc ttcttctttgtcatcgtcattctgctggccatcattcagggtttgattattgatgccttt ggtgagctgagagaccagcaggagcaggtgaaggaggacatggagaccaaatgcttcatc tgtgggattgggaatgactactttgaccggacgcctcacgggtttgaaacccacacctta caagagcacaacctagctaactacctgttcttcctgatgtacctgattaacaaggatgag actgaacacacgggtcaggagtcgtttgtgtggaagatgtaccaggagagatgctgggac ttcttccctactggagactgcttccgtaagcaatatgaggaccagttgggttag

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