Eublepharis macularius (Leopard gecko): 129323384 Help Entry 129323384         CDS       T09084                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism emc  Eublepharis macularius (Leopard gecko) Pathway emc04020   Calcium signaling pathway emc04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:emc00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     129323384 (RYR3)    04020 Calcium signaling pathway     129323384 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:emc04040]     129323384 (RYR3) Ion channels [BR:emc04040]  Voltage-gated cation channels   Ryanodine receptor    129323384 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 CCDC106 Motif Other DBs NCBI-GeneID:  129323384 NCBI-ProteinID:  XP_054825893 UniProt:  A0AA97IUM1 LinkDB All DBs Position 2:62394996..62874580 Genome browser AA seq 4865 aa AA seqDB search MIFISTFLTHLYLEEDDEVVLQCIANIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVPPD LCICNFVLEQSLSVRALQEMLANTGDNSSEGAAQGGGHRTLLYGHAILLRHSFSGMYLTC LTTSRSQTDKLAFDVGLQENAAGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYL HLSVSYGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVLRLFHGHDECLTIPSTEQN DSPHKRVFYEAGGAGAHARSLWRVEPLRISWSGSNIRWGQPFRLRHITTGQFLALTEDQG LVLLDREKADTKSTSFCFRASKALKEKLDSAHKRDIDGMGVPEIKYGDSICFVQHVASTL WLTYKAQDAKTVRLGPLKRKVILHQEGHMDDGLTLQRCQHEESQAARIIRNTTRLFSQFI SGNNRTSTPITLPIEEVLQTLQDLITYFLPPEDELEHEDKQNKLRSLKNRQNLFKEEGML ALVLNCIDRLNVYYSTTHFTGIGREESGTAWKEILNLLYKLLAALICGNRNNCAQFSNNL DWLISKLDRLESSSGILEVLHCILIESPEALNLIEESHIKSIISLLDKHGRNYKVLDVLC SLCLCNGVAVRANQNLICDNLLPRRDLLLQTRLVNDVTSMRPNIFLGIAEGSAQYKKWYF ELIIDQVDPFLTVEPTHLRVGWASTSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLWSG RIPRAVASVNQHLLASDDVVSCCLDLGAPSISFRINGQPVQGMFENFNTDGLFFPVVSFS AGIKIRFLMGGRHGEFKFLPPAGYVPCYEALLPKEKMKLEPVKEYKRDSDGVRDLLGTMQ FLSQANFIPCPIDTSQILLPFHLEKIRDKLAENIHELWGMNKIELGWAYGKIRDDNKRQH PCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIVHVNPGAEEDLKKIKLQKNYMMSNG YKPAPLDLSEVKLSPAQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLVPY PLLDERTKKSNRDSLREAVRTFVGYGYNIEPPDQELVDQTVEKVSIDKIRFFRVEQSYAV KTGKWYFEFEAVTGGDMRVGWARPACRPDVELGADDQAFVFEGSKGQRWHQGSGFFGRNW QPGDVVGCMINLDDKSMIFTLNGELLITNKGSELAFADFEIDNGFVPICSLGLSQIGRMN FGRDASTFKYYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKNHPHIEVTRIDGN IDSPPRLKVTHKTFGTQNSNAEMIYCRLSMPIEFHSSFNYCTGIELIDGFQKRKQNQEIP GHPTTYYYSARIFAGQDLSSVWIGWVTPDYHFYSEHFDLNKNCTVTVTLGDERGRVHESV KRSNCYLVWGGETSVTSQRSGRSNVDLEIGCLVELATGMLSFTVNGKELGTFYQVEPNTK LFPAVFLQPTSTNLVQFELGKLKNTMPLSAAIFKSEEKNPIPQCPPRLDVQTLTPVVWSR MPNTFLKAEAERVSDRHGWVVQCLEPLQMMALHIPEENRCIDILELCEQEDLMRFHYHTL KLYSSVCALGNNRVAYALCSHVDLSQLFYTIDNQYLPGLLRSGFYDLLISIHLEYSKEAK LMMNNEFIIPITDETRKIKLFPEEKKGHGLPGVGLSTCLKPDFKFSTPCFILSHEDHQKP SPEIPLDILKSKAISMLTEAVYCSGTHIRDPVGGKVEFQFVPVLKLIGTLLIMGVFDDHD VKQILLLIDPCVFGEPMDEAMERTEKEDVTQIEEKAVEAGEKAMKETKTPIKGLLQTRLP ESVKLQMCELLNYFCDCELKHRVEAIVSFADTYVSKLQYNQKYRYNELMQALNMSAALTA RKTKEFRSPPQEQINMLLNFQLGEDCPCPEEIREELYEFHDDLLIHCGIPLEEEEEEEDD ISWTGKLRSLIYKIKGLPKTEKKEPTEEEEKYPTTLKELISQTMVRWAQEDLIQDPELVR IMFNLLRRQYDSIGELLQALRKSYTISAASVQDTINLLAALGQIRSLLSVRMGKEEELLM INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKSQIAFPKMVASCCRFLCYF CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALEEPDLE KVVTYLAGCGLQSCPMLLAIGYPDIGWNPIEGERYLSFLRFAVFVNGESVEENASVVVKL LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKRELSLEEDEEEIVHMG NAIMSFYSALIDLLGRCAPEIHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPTG NKDGTVTEPDMSASFCPDHKAPMVLFLDRVYGIKDQSFLLHLLEVGFLPDLRACASLDTA SLSTTETALALNRYICTAVFPLLTRCAALFSGTEHYVSLIDSTLHTIYRLSKGRSLTKAQ RDTIEECLLAICHHLRPSMLQQLLRRLVFDVPLLNEYCKMPLKLLTNHYEQCWKYYCLPS GWGNYGIAAEEELHLTEKLFWGIFDSLSHKKYDPELFRMALPCLSAIAGALPPDYLDTRI TSTLEKQTSVDAEGNFDPKPINTVNFTLPEKLEYIINKYAEHTHDKWACEKSNSGWKYAA CLDENMKTHPLIRPFKTLIEKEKEIYRWPARESLKTMLAMGWTLERTKEDSIVQQRENEK LRTISQSSQGNGYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKIELENKGGGSH PLLVPYDTLTAKEKSRDREKAQELFKFLLVNGIVISRGLNDLELDASSMEKRFAYKFLRK ILKYVDSAHEFIAHLEAIVISGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHCLYFLSSPA KPLSSSGYASNKEKEMVASLFCKLAALVRHRISLFGSDATTMVSCLHILAQTLDTRTVMK SGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPILTS IFDHVAQHHFGTDLLLGDVQVSCYRILCSLYSLGTGKNIYVERQRPALGECLASLAAAIP VAFLEPSLNLFNPLSVFNTKSSRERALLGMPETVEEMCPEIPHLDGLMKEINSLAESGAR YTEMPHVIEVILPMLCNYLSYWWGKGPENIPESSGPCCTMVTSEHLSIILGNILKIINNN LGIDEASWMKRIAVYAQPIISKARPDLLKSHFIPTLEKLKKKAIKIVMEEEQLKADNKTD TQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKKPDADSDELFRMVAEVFILWC KSHNFKREEQNFVIQNEINNLAFLTGDSKSKISKAMQVKSGGHDQERKKSKRRGDLYSIQ TSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSCKDTEEEIKEHLRSNLHLQEKSDDP AVKWQLNLYKDVLKTEEPADPEKTVERVQRISAAVYHLEQVEQPLRSKKAVWHKLLSKQR KRAVVACFRMAPLYNLPRHRSINLFLHGYQKYWIETEEYSFEEKLVQDLATPSKKSEEEE EEAEKHPDPLHQIILHFSRNALTERSKLDNDPLYTAYSAMMAKSCQSGEDDEDDDEEKEK TFEEKEMEKQKTLYQQSRLHERGAAEMVLQMISASKGEMGPMVVETLKLGIAVLNGGNSV VQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERG EKVLQNDEFTKDLFRFLQLLCEGHNNDFQNYLRTQMGNTTTVNIIISTVDYLLRLQESIS DFYWYYSGKDVIDESGQRNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVG FLHVFANMQMKLSQDSSQIELLKELLDLLKDMVVMLLSLLEGNVVNGTIGKQMVDTLVES SSNVEMILKFFDMFLKLKDLTSSEAFKEYDPESKGIISKKEFQKAMEGQKKYTQSEIEFL LSCAEADENDMFNYVDFVERFHEPAKDIGFNVAVLLTNLSEHMPNDSRLQTLLDPAESVL NYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKM ELFVNFCEDTIFEMQLASQISESDSVDRLEEEEEDEPCYIREVGEEKEEKSLESISAFAM ACIAVKTNAAAFLKMVRLKNLRKQYRKVKKMTVKELVKVSFSFFWMLFVGFFQMLFTIVW GIFQILWNTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDILEAEKAEATDHGITAEI VQFVKNEKGETDILSDIFGIHTKKESGSKHGHDVGLGDIADIIGSETPPSLESTTHKKKK AQAVEVVKDDESETRTESEKADMEDGEKQDRVKDDVYSEHLEAEEPRKRKRRHGQKIEKP DAVMANFFKVLEVYQTKMLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPFEEIEEE SDLWHSLDEDEDEEGVVFFVLQESTGYMAPTLRALAVVHTIISFVCVVGYCCLKVPLVVF KREKDIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGDL YGAERIAELLGLDKNALDFSPVEHTELEEASLLSWLGSIDAKYHIWKLGVVFTDNSFLYL AWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYT VVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMY RIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTTP HGFEMHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQY EDQLG NT seq 14598 nt NT seq  +upstreamnt  +downstreamnt atgatattcatcagcacatttctgacccatctttatctagaagaggatgatgaagtagta cttcagtgtattgctaacattcacaaagaacagcgaaagttctgcctggcagctgaggga cttgggaatcgcctgtgctttctggaaccaacgtcagaagctaaatatgtccctcctgac ctttgcatctgtaactttgtattggagcagtctttatctgtcagagctcttcaggaaatg ctggcaaatacaggagacaattccagtgaaggggcagcccaaggaggtggtcatagaaca ctgctgtatggccatgccattctacttcgtcattccttcagtggaatgtatctgacatgc ttgactacatcaagatctcagacagataagcttgcatttgatgtggggctacaagagaat gcagcaggtgaagcttgctggtggacaatacatcccgcatctaaacagaggtctgaagga gaaaaagtccgtattggagatgatcttatcttagttagtgtgtcctctgaaaggtatctg catctctctgtatcatatggaaacatacaagtggacgcgtcttttatgcagacactatgg aatgttcaccctacttgttcagggagtagcatagaggaaggatatcttcttgggggacat gtattgcgcttatttcatggccatgatgagtgtttaacaatcccatctacagaacagaat gattcaccacacaagcgagtgttttatgaagcaggaggagctggtgcacatgcaaggtca ttgtggagagtagaacctcttcgaataagctggagtgggagtaatattcgctggggacaa ccttttcgcctgcgacatattacaacaggacaatttttagccctgacagaagaccaaggc cttgtcttgttagacagagaaaaggctgatactaaatccacttccttttgtttcagagca tcaaaggctttaaaagaaaaactggattctgctcataagcgtgatattgatggcatgggc gttcctgaaataaagtatggtgattccatttgctttgtgcagcatgtagccagcactctg tggctgacttacaaagcacaggatgctaaaacagtgcgcttgggaccactgaaaaggaag gttatattgcatcaagaaggacatatggatgatggtctcacattacaaagatgtcaacat gaagaatcccaggctgctcgaatcattcgcaacacaacaagattattcagtcagtttata agtggaaataacagaacttcaactcccatcactctgcctattgaagaggtacttcagaca ctgcaagatctgattacatattttctgcctccagaagatgagctagaacatgaagataaa cagaataaacttcgttctctcaagaatagacaaaatctattcaaagaagagggaatgctg gcactggttttgaactgcatcgatcgcttaaatgtctactatagtaccactcattttaca gggattggcagagaggaaagtggtacagcatggaaagaaattttgaatctcctttacaaa ttgctagctgctcttatatgtggtaacagaaataattgtgctcagttttctaataactta gattggctaattagcaaattggacagactagaatcatcttcaggtattttggaagttttg cactgcatcttgattgaaagcccggaggctttaaatttgatagaagaaagtcatatcaaa tctatcatttcattgctggataagcatgggcgcaactataaggttcttgatgtgctttgc tccctctgtctctgtaatggagtagcagtgcgtgctaatcagaatttaatctgtgacaat cttctccctcgaagagatctacttttacaaacacggctggtgaatgatgtaacaagtatg agaccaaacatatttctaggaattgccgagggctcagcccaatataagaaatggtacttt gaactaataattgatcaagtagatccatttttgaccgtagaacccacacatctgcgggtt ggctgggcttcaacatcgggctatgctccttatcctggaggtggagaaggatggggaggc aatggtgttggcgatgacctgtactcatatggatttgatggacttcatctgtggtctggt cgaatacccagagctgtcgcatctgtgaaccagcatttgctagcatctgacgatgtggtc agctgttgcctggatttaggggcacccagtatttctttccgcattaatggacaacctgta caaggaatgtttgaaaacttcaacactgatggactgttttttcctgtagtgagcttctca gcaggcatcaaaatccgtttcttaatgggtgggcgccatggagaattcaagtttctacct cctgctggctacgtgccttgctatgaagctttacttccaaaagagaaaatgaagctggaa ccagtaaaagaatataagagggattctgatggagttagagatttgcttggtacaatgcag tttctctcccaagctaactttattccttgtccaattgacaccagccagattcttttgcct tttcatcttgagaaaatcagggacaaactcgctgaaaatatccatgaactatggggaatg aataaaatagaactcggttgggcttacggcaagatacgagatgataataaaagacaacac ccttgtctagtagaattttcaaaattgcctgaaacagagaagaactacaacctacaaatg tcaacagaaactctgaaaactcttctggcccttggatgccatattgttcacgtcaatcca ggagcagaggaagatcttaagaaaatcaagctccaaaaaaattacatgatgtcaaatggt tacaaaccagcgcctctagatctttctgaagtgaaattatcacctgcacaagaagttttg gttgataaacttgcagaaaatgcacataatgtctgggcaaaagacagaataaaacaaggt tggacctatgggattcagcaggatctcaaaaacaaacgaaaccctcgactggtaccatat ccattattagacgagcgtactaagaaatcaaacagagacagccttcgtgaagctgttcgt acctttgtgggttatggatataatattgagccaccagatcaagaattagttgaccaaact gtggaaaaagtgagcattgacaagatacgcttcttcagagtagagcagtcttatgctgtt aagactggaaagtggtattttgaatttgaagctgtaacgggaggagatatgcgtgttgga tgggcaagaccagcttgtcgtccggacgtagaattgggagctgatgaccaagcatttgtg tttgaaggcagcaaaggtcaacgttggcaccaagggagtggattttttggacgaaattgg caaccaggagatgtggtgggctgtatgataaatctagatgacaaatcaatgatctttact ctgaatggggagttgcttataacaaataaaggttcagagcttgcttttgctgattttgaa atagataatggttttgtccctatatgctcattgggtctgtctcagattggtcgaatgaat tttggaagggatgccagcaccttcaaatattatacaatgtgtggccttcaagaaggcttt gaaccttttgctgtcaacatgaacagagatgttgctatgtggtttagcaaacgcttgcca acatttgtcaacgtgccaaaaaaccacccgcatattgaggtgacaagaattgatggaaat attgatagcccaccacgtttaaaagtaacccataagacgtttggaacacagaatagtaat gcagaaatgatatattgtcgcttgagtatgcctattgaattccattcatcttttaactac tgtactggtatagaacttattgatggtttccaaaaaagaaaacagaaccaagagattcct ggtcatccaacaacatactattactcagcgcgcatctttgctggtcaagacctatcttca gtgtggattggttgggtaactcctgactaccacttttacagtgaacattttgacttaaat aagaactgcacagttacagttactttgggagatgaaagaggcagagttcatgaaagtgta aaacgtagcaattgctacctggtctggggaggagaaacgtccgttacttcacagagatca ggtcgcagtaatgttgatttagaaattggatgccttgtcgaattggctactggaatgtta tcattcacagttaatggaaaggagctgggaacattctaccaggttgaaccaaacacaaaa ttatttccagcagtttttttacagcccacgagcacaaacctggtgcagtttgaacttggt aaattaaagaacaccatgcctttatcagcagcaatctttaaaagtgaagagaaaaaccct attccccagtgccctcctcgactagatgttcaaacactcacaccggttgtgtggagcaga atgccaaacactttcctgaaggcagaggctgagcgagtcagtgatcgccatggctgggtg gtgcagtgtctggaacctttgcagatgatggcccttcatattcctgaagaaaacagatgt attgatattttggagctatgcgaacaagaggatttgatgaggttccactaccatacttta aaactttatagctctgtgtgtgccctggggaacaacagagtagcttatgcactttgcagc catgttgatctttctcagttattttatacaatagataatcaatatttacctggactctta cgatctggattctatgacttgcttatcagcattcatttagaatattccaaggaagctaag ctcatgatgaacaatgaatttataattccaattacagatgaaacaagaaaaattaaatta tttccagaggaaaaaaaggggcatggtttacctggagtaggacttagtacctgtttgaaa ccagattttaagttctctactccttgttttattttatctcatgaggatcatcagaaacct agtccagagataccacttgatatactaaagtctaaagctataagtatgctaacagaagca gtctactgcagtggcactcacatacgagaccctgttggagggaaagttgagttccagttt gttcctgttcttaaacttataggaactttgctcataatgggagtttttgatgatcatgat gttaaacagattttactactgattgatccatgtgtgtttggtgagcccatggacgaagca atggagagaacggaaaaggaggatgttactcagatagaagaaaaggctgtagaggctggg gaaaaggcaatgaaggaaaccaaaactccaataaaaggcttgctgcaaacaagattacct gaatctgttaaactccagatgtgtgagctgctaaattatttctgtgactgtgagctgaaa cacagagtggaagccattgtatctttcgcagatacttatgtttcaaaactgcaatataac cagaaatacagatataatgaactcatgcaggccctgaatatgtctgctgctttgactgcc agaaaaacaaaggaatttcggtctcctccacaagaacagattaatatgttgctaaatttt caactgggagaagattgtccttgtccagaggagattcgagaagagctatatgaatttcat gatgatctcctaattcattgtggaattccattagaagaagaggaggaggaagaagatgat atttcttggactggtaaactacgttctttgatatacaaaataaaagggctaccaaagaca gaaaagaaagaacctacagaggaggaagaaaaatatcctactactttgaaggagttgata tctcaaactatggttcgctgggctcaagaagatctgatccaggatccagaattagttcgc attatgtttaacctccttcgaaggcaatatgacagcattggtgagctactgcaagctctg aggaaatcctacactataagtgctgcctctgtgcaggatacaatcaatttattagcagca ctgggtcaaattcgctcccttctcagtgtcaggatgggaaaagaagaggaattgcttatg attaatggcctaggagatataatgaacaacaaagtattttatcagcatcctaatttaatg agagtcctgggtatgcatgagacggttatggaagtaatggtaaatgttcttggaggagac aaatctcagattgcatttcctaaaatggtggcaagttgttgtcggttcctgtgctatttc tgccgaatcagtcgccaaaaccaaaaagctatgtttgagcatctaagctacttacttgaa aacagcagtgtgggacttgcctctccttcaatgaggggttctactccactagatgtagca gctgcctctgtaatggacaataacgagcttgcactggcattggaggagccggacttggaa aaggttgtaacctacttggcaggttgtggacttcagagctgcccaatgctcttggcaata ggatatcctgacattggttggaatccaatagagggagaacgttacctatcattcttaaga tttgctgtttttgttaatggggaaagtgttgaggagaatgccagtgttgttgtcaagctt cttattcgacgaccagaatgttttggcccagctcttagaggagaaggaggaaatggtttg ttagctgctatgcaaggagcaattaagatctccgagaatccagctcttgaccttccctct cagggatataaaagggaactcagccttgaggaagatgaggaagagattgtgcatatgggc aatgcaattatgtctttctactcagctcttatagatttgcttgggcgctgtgcaccagaa atacacctcatccaaactggaaagggtgaagccattagaatacggtcaatcctgcgctcc ctggtgccaacagaagacttggttgggattataagcataccactaaaactgccaacagga aacaaagatggaacagttactgagcctgacatgtctgcaagtttctgtcctgaccataag gcacccatggtgctatttcttgatcgtgtctatggtataaaagaccaaagcttccttctc catctccttgaggttggatttttaccagatttgagagcatgtgcctcactggatacagct tctttgagtaccacggagacagctcttgctctaaatagatatatttgcacagctgtgttt ccattacttacaaggtgtgctgctctgttttcgggaactgagcattatgtatctctgatt gattccacacttcatacaatatatcgactctccaaaggacgctcccttacaaaagcacaa agagacactattgaagaatgcttgcttgctatctgccatcacttgcggccttctatgtta cagcagctattgcgacggctagtttttgatgtacccttacttaatgaatactgtaaaatg ccacttaagcttctaacaaatcactatgagcaatgctggaagtattactgcttgccttcc ggatggggaaattatggaattgcagctgaagaagagttacatttaactgagaaacttttc tggggaatatttgattccctctcccataagaagtatgatccagagctcttccgaatggcc ttaccctgtttaagtgctatagctggggctttgccaccagattatttagacactcgaatt acctcaactttagaaaagcagacttcagtagatgctgaaggaaactttgatcccaaacct atcaacacagtgaactttactcttcctgaaaagctggaatatatcatcaacaagtatgct gaacatacacatgacaaatgggcttgtgagaagagtaatagtggatggaagtatgctgct tgtctagatgaaaatatgaagacacatcctttaataaggccttttaaaacattaattgaa aaggaaaaggaaatatatcgatggcctgccagagaatctcttaaaactatgttagcaatg ggctggactctagaaaggaccaaagaagattcgatagtacagcaacgggaaaatgaaaag ctccgcactatatcacagtccagtcaaggaaatggatacagcccagctccacttgatctg tcaaatgttgtactctctagggaactccagggtatggttgaagtggtggcagaaaactat cataacatttgggctaaaaagaagaaaattgaattggaaaataaaggtggaggcagccat cctttgttggtaccttatgacactttgacagccaaagaaaagtctcgggacagggagaaa gcacaagaactttttaaatttcttttagtgaatggaatcgtcatatctagaggtttaaat gacttggagttggatgcttcatctatggaaaaaaggttcgcctacaagtttctgaggaag attctaaaatatgttgactctgctcatgaatttattgcacatttagaagccattgtcatc agtggaaaaactgagaaatcaccacatgaccaagaaatcaaattctttgcgaaagttcta ctgccattggttgaccagtactttaccaaccactgcctctatttcctctcttccccagct aagccactcagcagtagtggatatgcttcaaataaagaaaaagaaatggttgcaagcctt ttctgcaaacttgctgctcttgttagacataggatttcactttttggtagcgatgctact acgatggttagttgcctacacattttagctcagacactagatacaagaacggtcatgaaa tcaggctcagagctggttaaagcaggattgcgtgctttctttgaaaatgcagctgaagat ctggagaagacatcagaaaatcttaaacttggaaaatttacacattcccgaacacaaatt aaaggagtctcacagaacatcaactacactacagtagcattgttacctatcttaacatca atttttgaccatgttgctcagcatcattttggcactgatttgcttttaggtgacgttcaa gtttcatgttacaggattctttgtagcctatactctcttggaactggaaagaatatctat gttgaaaggcaacgtcccgctctcggtgagtgcttagcttcccttgcagcagcaattcca gtagccttccttgaaccttctctcaatcttttcaatccactttctgtcttcaacacaaaa tcttccagagagagagcgcttttaggtatgcctgaaacggtagaagaaatgtgtccagaa attcctcacttggatggcttaatgaaagaaataaacagcttggcagagtctggagccaga tatactgaaatgccacatgtgattgaggtgatcttgcccatgctgtgcaactatctatca tactggtgggggaaagggcctgaaaacattcctgaaagtagtgggccctgctgcacaatg gtaacctctgagcacctcagcataattctgggaaacattttgaaaatcatcaacaacaac ctggggatagatgaagcatcctggatgaagagaatagcagtgtatgctcagccaatcatt agcaaagccaggccggatcttctgaaaagtcacttcattcccacattggaaaaactaaag aagaaggccataaaaatagtgatggaggaggaacaactgaaagcagacaataaaactgat actcaggaagcagaactcctcattctagatgaatttgctgttctttgtcgagacctttat gctttttatcccatgttgatccgctatgtagacaacaacagatcaaactggctcaaaaaa ccagatgcagattctgatgaactttttcgaatggtagctgaagtcttcatcctctggtgt aaatcacataacttcaagagagaagaacaaaattttgtgattcagaatgaaatcaacaat ttggcatttttgacaggagacagcaaaagtaagatatcaaaagccatgcaagtaaagtct ggaggtcatgatcaagaacgaaagaaatcaaagcgaagaggggacttatactcaattcag acatctctgattgtagctgcacttaagaaaatgcttccaattggattgaatatgtgtaca cctggagatcaagagctgatttctcttgctaagtccagatatagctgtaaagacacagaa gaagaaatcaaagaacacttacgcagtaacttgcatttgcaggagaagtcagatgatcct gcagtgaaatggcaattaaatctctataaagatgtcttgaaaactgaggagcctgctgat cctgagaaaactgtggaacgtgtgcaaaggatctctgcagctgtctatcatctggaacag gttgaacaaccattaagatcaaagaaagctgtgtggcacaaactcttgtcaaaacaacgt aaaagagctgttgttgcatgtttcagaatggcaccattatacaatttgccaaggcaccgc tctattaacctgttcctccatggttatcagaaatattggatagaaacagaggaatactca tttgaggagaaactagttcaggatttggctactccctcaaaaaaaagtgaggaggaggag gaggaagctgaaaaacatcccgatcctcttcatcaaattattcttcatttcagtcggaat gctctcactgaaagaagcaaactggataatgaccctttgtataccgcatattcagcaatg atggcaaagagctgtcaaagcggagaagatgatgaagatgatgatgaagaaaaggagaag acatttgaggaaaaagaaatggaaaaacaaaaaactctttatcagcagtctcgactccat gaacgtggagctgctgagatggtattacagatgattagtgccagtaaaggggaaatgggg cccatggtagttgaaaccttgaaacttggtattgctgttctaaatggaggtaactctgtc gttcagcagaaaatgttggactatctgaaagagaaaaaagatgcgggttttttccagagc ctttcaggcttaatgcagtcttgcagtgttcttgacttgaatgcctttgaaagacaaaat aaagcagaaggccttggaatggttactgaagaaggaacactcatcgtacgtgagcgtggt gagaaagtactacagaatgatgagtttactaaagatctgtttagatttttacaactgctg tgtgaaggtcataacaatgattttcagaattatctgcgcactcagatgggcaataccaca acagtgaatattattattagcacagttgattatctcttgcgtcttcaggaatcaattagt gacttctattggtactactctggaaaggatgtgattgacgaatctgggcaacgtaacttc tctaaagcattggctgtaaccaaacagatttttaattcacttactgaatatatacagggt ccttgcattggaaaccagcagagcctggcgcacagtagattgtgggatgcagttgttggc ttccttcatgtttttgctaacatgcaaatgaaactttcacaggattccagccagattgaa ctgctgaaggagctactggatcttctgaaggatatggtggtgatgctcttgtccctactt gaaggtaatgttgtaaacggcacaattggaaaacagatggtggacactctggttgaatca tctagcaatgtagaaatgatcttaaagttctttgacatgtttctcaagctgaaagatctg actagctcagaagccttcaaagagtatgatccagaaagtaaaggcataatctcaaagaaa gaattccagaaagccatggaaggtcagaagaaatatactcagtcagagattgagttcctg ctgtcctgtgcagaggctgatgaaaatgacatgtttaactatgtggattttgttgaaaga tttcatgagccagctaaagacattggatttaatgtggcagtgctgttaacaaacctttca gagcatatgccaaatgattcacgacttcaaactttattagacccagcagaaagtgtcctt aactattttgaaccgtatctggggcgaattgagataatgggtggtgccaagaaaatagaa cgtgtttattttgagattagtgaatctagcaggacacaatgggagaaacctcaagtgaaa gaatcaaaaaggcagtttattttcgatgttgtaaatgaaggtggagaacaagagaaaatg gagctgtttgtcaacttctgtgaggacacaatttttgaaatgcagttggcatctcagatc tctgaatcagactctgtcgacagacttgaggaagaggaagaagatgagccatgctacata agggaagttggagaagagaaagaagaaaagtcccttgaatccatttcagcttttgcaatg gcatgtattgcagtaaagacaaatgctgctgcatttttaaaaatggttagattaaaaaac ttaaggaaacaatatagaaaagtgaagaagatgacagtaaaagaattagtaaaagtgtct ttttcctttttctggatgcttttcgtagggttctttcagatgctcttcactatagtgtgg ggcatttttcaaattctttggaacactgtgtttgggggtggcttagtggaaggagccaaa aatatcagagtgaccaaaatactaggagacatgcctgatccaacacagtttggaatccat gatgatatccttgaagcagaaaaagctgaagctacagaccatgggatcacagctgaaatt gtgcagtttgtaaaaaacgaaaagggagaaacagacatactgtcagatatttttggcatt catacaaagaaagaaagtggatcgaaacatggtcatgatgttggcctaggggatattgcc gatattattggatcagaaacccctccttctttggaaagcacaactcacaagaagaaaaag gcacaggcagttgaagtggtaaaggacgatgaatcagaaacaagaacagaatctgagaaa gctgacatggaggatggtgagaaacaagatagagtaaaggatgatgtatattccgaacat ttggaagctgaagaaccccggaaaaggaaacgaagacatgggcaaaaaatagaaaaacct gatgcagttatggcaaacttctttaaagtactggaagtttatcagacaaaaatgctgcat tatttggctagaaatttttacaatttaagatttctagcactttttgttgccttcgccatc aactttatcctgctcttctacaaggtgactgaagagccatttgaggaaatagaggaagaa tctgacctatggcattctttggatgaagatgaggatgaagagggtgtggttttctttgtt ttgcaagaaagtacaggctatatggctcccacactaagggctctagctgttgttcataca atcatctcctttgtatgtgttgttggatactgttgcctgaaggttcccctggttgtattc aaacgggaaaaggatattgcaaggaaactggaatttgatggtctgtacattactgaacag ccctctgaagatgatattaaaggacagtgggatcgcctagtcataaacactccatctttt cctaataattattgggacaagtttgtgaaacgaaaggtgataaacaagtacggtgattta tatggagcagaacgcattgcagaactcttaggtctggacaaaaatgctcttgactttagt ccagtggaacatacggaactagaggaggcatctcttctttcatggttaggttctattgat gccaagtaccatatctggaagctcggtgtagttttcactgataattccttcttatactta gcttggtatacaaccatgtcgatccttggacactacaacaacttcttctttgctgctcac ttgctcgatattgctatggggtttaagacactgcgtaccattctgtcttctgtaactcac aatggcaaacagctcgtgttgactgttggacttctggctgtagtagtatacctttacaca gtagtggcattcaacttcttccgtaaattctataacaaaagtgaagatgaggatgaacca gacatgaagtgtgatgacatgatgacttgttacttgttccacatgtatgtgggtgtaaga gcagggggtggtattggagatgaaattgaagaccctgctggagatccttatgaaatgtat cgcatcgtttttgacatcacatttttcttctttgtcattgtcatcttgctggccatcatt caaggtctcattattgatgcctttggtgaattaagagatcagcaagaacaagtcaaagaa gatatggagacaaaatgtttcatttgtggaattggaaatgactactttgacacaactccc catgggtttgaaatgcacactttgcaagagcataacttagccaactacctgttttttctg atgtatctcattaataaggatgaaacagaacacactggacaggaatcatatgtatggaaa atgtatcaagaaagatgctgggatttctttccagctggagattgctttcgtaaacagtac gaagatcaacttggataa

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