KEGG   PATHWAY: eoj00540Help
Entry
eoj00540                    Pathway                                

Name
Lipopolysaccharide biosynthesis - Escherichia coli O26:H11 11368 (EHEC)
Class
Metabolism; Glycan biosynthesis and metabolism
BRITE hierarchy
Pathway map
eoj00540  Lipopolysaccharide biosynthesis
eoj00540

Ortholog table
Module
eoj_M00060  Lipopolysaccharide biosynthesis, KDO2-lipid A [PATH:eoj00540]
eoj_M00063  CMP-KDO biosynthesis [PATH:eoj00540]
eoj_M00064  ADP-L-glycero-D-manno-heptose biosynthesis [PATH:eoj00540]
Other DBs
BSID: 127282
GO: 0009103
Organism
Escherichia coli O26:H11 11368 (EHEC) [GN:eoj]
Gene
ECO26_0183  lpxA; UDP-N-acetylglucosamine acetyltransferase [KO:K00677] [EC:2.3.1.129]
ECO26_0099  lpxC; UDP-3-O-acyl N-acetylglucosamine deacetylase [KO:K02535] [EC:3.5.1.108]
ECO26_0181  lpxD; UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase [KO:K02536] [EC:2.3.1.191]
ECO26_2701  probable glucosamine acetyltransferase [KO:K02536] [EC:2.3.1.191]
ECO26_0557  lpxH; UDP-2,3-diacylglucosamine pyrophosphatase [KO:K03269] [EC:3.6.1.54]
ECO26_0184  lpxB; tetraacyldisaccharide-1-P synthase [KO:K00748] [EC:2.4.1.182]
ECO26_1041  lpxK; lipid A 4'-kinase [KO:K00912] [EC:2.7.1.130]
ECO26_4301  kdsD; D-arabinose 5-phosphate isomerase [KO:K06041] [EC:5.3.1.13]
ECO26_1728  kdsA; 3-deoxy-D-manno-octulosonate 8-phosphate synthase [KO:K01627] [EC:2.5.1.55]
ECO26_4302  kdsC; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase [KO:K03270] [EC:3.1.3.45]
ECO26_1044  kdsB; 3-deoxy-manno-octulosonate cytidylyltransferase [KO:K00979] [EC:2.7.7.38]
ECO26_4967  kdtA; 3-deoxy-D-manno-octulosonic-acid transferase [KO:K02527] [EC:2.4.99.15 2.4.99.14 2.4.99.13 2.4.99.12]
ECO26_1387  lpxL; lauryl-acyl carrier protein (ACP)-dependent acyltransferase [KO:K02517] [EC:2.3.1.241]
ECO26_2707  lpxM; myristoyl-acyl carrier protein (ACP)-dependent acyltransferase [KO:K02560] [EC:2.3.1.243]
ECO26_p1-86  putative lipid A myristoyl transferase MsbB2 [KO:K02560] [EC:2.3.1.243]
ECO26_0238  lpcA; D-sedoheptulose 7-phosphate isomerase [KO:K03271] [EC:5.3.1.28]
ECO26_4154  rfaE; fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase [KO:K03272] [EC:2.7.7.70 2.7.1.167]
ECO26_0205  gmhB; D,D-heptose 1,7-bisphosphate phosphatase [KO:K03273] [EC:3.1.3.83 3.1.3.82]
ECO26_4978  rfaD; ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding RfaD [KO:K03274] [EC:5.1.3.20]
ECO26_4976  RfaC; ADP-heptose: LPS heptosyl transferase I RfaC [KO:K02841] [EC:2.4.-.-]
ECO26_4977  rfaF; ADP-heptose: LPS heptosyl transferase II RfaF [KO:K02843] [EC:2.4.-.-]
ECO26_4969  rfaG; glucosyltransferase I RfaG [KO:K02844] [EC:2.4.1.-]
ECO26_4972  waaY; lipopolysaccharide core biosynthesis protein WaaY [KO:K02850] [EC:2.7.1.-]
ECO26_4970  rfaP; lipopolysaccharide core biosynthesis protein FfaP [KO:K02848] [EC:2.7.1.-]
ECO26_4968  rfaQ; lipopolysaccharide core biosynthesis protein RfaQ [KO:K02849] [EC:2.4.-.-]
ECO26_5060  eptB; predicted metal dependent hydrolase EptB [KO:K12975] [EC:2.7.8.42]
ECO26_5072  yijP; conserved predicted inner membrane protein [KO:K19353] [EC:2.7.8.-]
ECO26_4075  conserved predicted membrane protein [KO:K19353] [EC:2.7.8.-]
ECO26_p1-87  putative membrane protein [KO:K19353] [EC:2.7.8.-]
ECO26_4971  UDP-D-galactose:(glucosyl) lipopolysaccharide-alpha-1,3-D-galactosyltransferase WaaI [KO:K03275] [EC:2.4.1.-]
ECO26_4973  putative UDP-glucose: (galactosyl) LPS alpha1,2-glucosyltransferase WaaJ [KO:K03279] [EC:2.4.1.58]
ECO26_4975  waaL; lipid A-core: surface polymer ligase WaaL [KO:K02847] [EC:2.4.1.-]
Compound
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00199  D-Ribulose 5-phosphate
C00229  Acyl-carrier protein
C01112  D-Arabinose 5-phosphate
C01187  3-Deoxy-D-manno-octulosonate
C04121  CMP-3-deoxy-D-manno-octulosonate
C04478  3-Deoxy-D-manno-octulosonate 8-phosphate
C04652  UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine
C04738  UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine
C04824  Lipid X
C04919  2,3,2'3'-Tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate
C04932  Lipid A disaccharide
C05223  Dodecanoyl-[acyl-carrier protein]
C05382  Sedoheptulose 7-phosphate
C05761  Tetradecanoyl-[acp]
C06022  UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine
C06024  3-Deoxy-D-manno-octulosonyl-lipid IV(A)
C06025  Di[3-deoxy-D-manno-octulosonyl]-lipid IV(A)
C06026  Di[3-deoxy-D-manno-octulosonyl]-lipid A
C06251  Lauroyl-KDO2-lipid IV(A)
C06397  ADP-D-glycero-beta-D-manno-heptose
C06398  ADP-L-glycero-beta-D-manno-heptose
C07836  D-glycero-beta-D-manno-Heptose 7-phosphate
C07838  D-glycero-beta-D-manno-Heptose 1-phosphate
C11472  D-glycero-beta-D-manno-Heptose 1,7-bisphosphate
C19877  4-O-Phospho-alpha-Kdo-(2->6)-lipid IVA
C19878  D-glycero-alpha-D-manno-Heptose 7-phosphate
C19879  D-glycero-alpha-D-manno-Heptose 1,7-bisphosphate
C19880  D-glycero-alpha-D-manno-Heptose 1-phosphate
C19881  GDP-D-glycero-alpha-D-manno-heptose
Reference
PMID:9791168
  Authors
Heinrichs DE, Yethon JA, Whitfield C.
  Title
Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica.
  Journal
Mol Microbiol 30:221-32 (1998)
DOI:10.1046/j.1365-2958.1998.01063.x
Reference
  Authors
Kneidinger B, Marolda C, Graninger M, Zamyatina A, McArthur F, Kosma P, Valvano MA, Messner P.
  Title
Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli.
  Journal
J Bacteriol 184:363-9 (2002)
DOI:10.1128/JB.184.2.363-369.2002
Reference
PMID:9587193
  Authors
Wyckoff TJ, Raetz CR, Jackman JE.
  Title
Antibacterial and anti-inflammatory agents that target endotoxin.
  Journal
Trends Microbiol 6:154-9 (1998)
DOI:10.1016/S0966-842X(98)01230-X
Reference
PMID:9765561
  Authors
Shibayama K, Ohsuka S, Tanaka T, Arakawa Y, Ohta M.
  Title
Conserved structural regions involved in the catalytic mechanism of Escherichia coli K-12 WaaO (RfaI).
  Journal
J Bacteriol 180:5313-8 (1998)
KO pathway
ko00540   
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