KEGG   PATHWAY: fca05150
Entry
fca05150                    Pathway                                
Name
Staphylococcus aureus infection - Felis catus (domestic cat)
Description
Staphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the effectiveness of the immune system: secreting immune modulating proteins that inhibit complement activation and neutrophil chemotaxis or lysis, modulating the sensitivity to cationic antimicrobial peptides (such as defensin) by increasing the positive net charge of its cytoplasmic membrane, and expression of superantigens that prevent development of a normal immune response or cause an emetic response when ingested.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
fca05150  Staphylococcus aureus infection
fca05150

Organism
Felis catus (domestic cat) [GN:fca]
Gene
100169946  KRT18; keratin, type I cytoskeletal 18 isoform X1 [KO:K07604]
101084838  KRT24; keratin, type I cytoskeletal 24 isoform X2 [KO:K07604]
111556209  keratin, type I cytoskeletal 27 [KO:K07604]
101086103  KRT12; LOW QUALITY PROTEIN: keratin, type I cytoskeletal 12 [KO:K07604]
101086860  KRT40; LOW QUALITY PROTEIN: keratin, type I cytoskeletal 40 [KO:K07604]
101089661  keratin, type I cuticular Ha3-I [KO:K07604]
101089910  KRT32; keratin, type I cuticular Ha2 isoform X1 [KO:K07604]
101090156  KRT35; keratin, type I cuticular Ha5 [KO:K07604]
101090662  KRT19; keratin, type I cytoskeletal 19 [KO:K07604]
101090912  KRT14; keratin, type I cytoskeletal 14 [KO:K07604]
101091165  KRT16; keratin, type I cytoskeletal 16 [KO:K07604]
101091416  KRT17; keratin, type I cytoskeletal 17 [KO:K07604]
101087624  KRT36; keratin, type I cuticular Ha6 [KO:K07604]
101088127  KRT9; keratin, type I cytoskeletal 9 [KO:K07604]
101088377  keratin, type I cytoskeletal 42 [KO:K07604]
101087365  keratin, type I cuticular Ha8 [KO:K07604]
101087114  keratin, type I cuticular Ha1 isoform X3 [KO:K07604]
101086861  keratin, type I cuticular Ha1 [KO:K07604]
101086611  LOW QUALITY PROTEIN: keratin, type I cuticular Ha3-II [KO:K07604]
101090406  LOW QUALITY PROTEIN: keratin, type I cytoskeletal 15 [KO:K07604]
101083308  keratin, type I cytoskeletal 26 [KO:K07604]
102901728  LOW QUALITY PROTEIN: keratin, type I cuticular Ha8-like [KO:K07604]
101086610  KRT23; keratin, type I cytoskeletal 23 [KO:K07604]
111556208  KRT25; keratin, type I cytoskeletal 25 [KO:K07604]
101083814  KRT39; keratin, type I cytoskeletal 39 [KO:K07604]
105261177  KRT20; keratin, type I cytoskeletal 20 [KO:K07604]
101087886  keratin, type I cytoskeletal 13 [KO:K07604]
101085587  KRT10; keratin, type I cytoskeletal 10 isoform X1 [KO:K07604]
111559128  LOW QUALITY PROTEIN: keratin, type I cytoskeletal 39-like [KO:K07604]
111559129  keratin, type I cytoskeletal 40-like [KO:K07604]
111559138  LOW QUALITY PROTEIN: keratin, type I cytoskeletal 19-like [KO:K07604]
111559139  LOW QUALITY PROTEIN: keratin, type I cytoskeletal 15-like [KO:K07604]
101092680  FGG; fibrinogen gamma chain [KO:K03905]
101088468  complement C3-like [KO:K03990]
101093018  CFB; complement factor B [KO:K01335] [EC:3.4.21.47]
101093500  CFD; complement factor D [KO:K01334] [EC:3.4.21.46]
102900754  complement factor H-like [KO:K04004]
101089505  complement factor H isoform X1 [KO:K04004]
101100840  MBL2; mannose-binding protein C [KO:K03991]
101097166  MASP1; mannan-binding lectin serine protease 1 isoform X1 [KO:K03992] [EC:3.4.21.-]
101099568  MASP2; mannan-binding lectin serine protease 2 isoform X1 [KO:K03993] [EC:3.4.21.104]
101096082  C1QA; complement C1q subcomponent subunit A [KO:K03986]
101096331  C1QB; complement C1q subcomponent subunit B [KO:K03987]
101094773  C1QC; complement C1q subcomponent subunit C [KO:K03988]
101088940  LOW QUALITY PROTEIN: complement C1r subcomponent [KO:K01330] [EC:3.4.21.41]
111561323  C1R; LOW QUALITY PROTEIN: complement C1r subcomponent [KO:K01330] [EC:3.4.21.41]
101088676  C1S; complement C1s subcomponent [KO:K01331] [EC:3.4.21.42]
101092434  C2; complement C2 isoform X1 [KO:K01332] [EC:3.4.21.43]
101094346  complement C4-A [KO:K03989]
101090401  C5; complement C5 [KO:K03994]
101099383  C3AR1; C3a anaphylatoxin chemotactic receptor [KO:K04009]
101098593  C5AR1; C5a anaphylatoxin chemotactic receptor 1 isoform X1 [KO:K04010]
101087936  LOW QUALITY PROTEIN: high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
101087550  FCGR2B; Fc fragment of IgG, low affinity IIb, receptor (CD32) [KO:K12560]
493677  FCGR3A; low affinity immunoglobulin gamma Fc region receptor III-A precursor [KO:K06463]
105261212  FCAR; immunoglobulin alpha Fc receptor [KO:K06513]
101091916  FPR2; N-formyl peptide receptor 2 [KO:K04173]
101095261  PLG; plasminogen [KO:K01315] [EC:3.4.21.7]
101086649  CFI; complement factor I isoform X1 [KO:K01333] [EC:3.4.21.45]
101087945  SELPLG; P-selectin glycoprotein ligand 1 [KO:K06544]
101083565  SELP; P-selectin isoform X1 [KO:K06496]
101089421  ICAM1; intercellular adhesion molecule 1 isoform X1 [KO:K06490]
101085940  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
101087957  integrin alpha-M isoform X4 [KO:K06461]
101087258  ITGB2; integrin beta-2 [KO:K06464]
102902220  DEFB1; beta-defensin 1 [KO:K23125]
101101212  beta-defensin 103A [KO:K23126]
100533978  CAMP; cathelicidin antimicrobial peptide precursor [KO:K13916]
101085410  DSG1; desmoglein-1 [KO:K07596]
111559549  uncharacterized protein LOC111559549 [KO:K10785]
101088996  DRA; HLA class II histocompatibility antigen, DR alpha chain-like precursor [KO:K06752]
100169654  SLC26A3; chloride anion exchanger precursor [KO:K06752]
101098301  DLA class II histocompatibility antigen, DR-1 beta chain precursor [KO:K06752]
111556169  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
101082906  HLA class II histocompatibility antigen, DO beta chain isoform X2 [KO:K06752]
101084108  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
101088734  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
111556173  HLA class II histocompatibility antigen, DM beta chain-like isoform X1 [KO:K06752]
101090518  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
111560441  HLA class II histocompatibility antigen, DO beta chain-like isoform X1 [KO:K06752]
101090771  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
111560440  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
101082653  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
101090265  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
101084962  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
111560443  HLA class II histocompatibility antigen, DM alpha chain-like [KO:K06752]
111560444  HLA class II histocompatibility antigen, DO alpha chain-like [KO:K06752]
111560445  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
111556176  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
111558969  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
111558970  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
102899262  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
101085906  PTAFR; platelet-activating factor receptor [KO:K04279]
493683  IL10; interleukin-10 precursor [KO:K05443]
Compound
C11596  FMLP
C20898  Lipoteichoic acid
Reference
  Authors
Foster TJ
  Title
Colonization and infection of the human host by staphylococci: adhesion, survival and immune evasion.
  Journal
Vet Dermatol 20:456-70 (2009)
DOI:10.1111/j.1365-3164.2009.00825.x
Reference
  Authors
Foster TJ
  Title
Immune evasion by staphylococci.
  Journal
Nat Rev Microbiol 3:948-58 (2005)
DOI:10.1038/nrmicro1289
Reference
  Authors
Laarman A, Milder F, van Strijp J, Rooijakkers S
  Title
Complement inhibition by gram-positive pathogens: molecular mechanisms and therapeutic implications.
  Journal
J Mol Med 88:115-20 (2010)
DOI:10.1007/s00109-009-0572-y
Reference
  Authors
Rooijakkers SH, van Kessel KP, van Strijp JA
  Title
Staphylococcal innate immune evasion.
  Journal
Trends Microbiol 13:596-601 (2005)
DOI:10.1016/j.tim.2005.10.002
Reference
  Authors
Iwatsuki K, Yamasaki O, Morizane S, Oono T
  Title
Staphylococcal cutaneous infections: invasion, evasion and aggression.
  Journal
J Dermatol Sci 42:203-14 (2006)
DOI:10.1016/j.jdermsci.2006.03.011
Reference
  Authors
Torres BA, Kominsky S, Perrin GQ, Hobeika AC, Johnson HM
  Title
Superantigens: the good, the bad, and the ugly.
  Journal
Exp Biol Med (Maywood) 226:164-76 (2001)
DOI:10.1177/153537020122600303
Reference
  Authors
Atkins KL, Burman JD, Chamberlain ES, Cooper JE, Poutrel B, Bagby S, Jenkins AT, Feil EJ, van den Elsen JM
  Title
S. aureus IgG-binding proteins SpA and Sbi: host specificity and mechanisms of immune complex formation.
  Journal
Mol Immunol 45:1600-11 (2008)
DOI:10.1016/j.molimm.2007.10.021
Reference
  Authors
Silverman GJ, Goodyear CS
  Title
Confounding B-cell defences: lessons from a staphylococcal superantigen.
  Journal
Nat Rev Immunol 6:465-75 (2006)
DOI:10.1038/nri1853
Reference
  Authors
Goodyear CS, Silverman GJ
  Title
Staphylococcal toxin induced preferential and prolonged in vivo deletion of innate-like B lymphocytes.
  Journal
Proc Natl Acad Sci U S A 101:11392-7 (2004)
DOI:10.1073/pnas.0404382101
Reference
  Authors
Haupt K, Reuter M, van den Elsen J, Burman J, Halbich S, Richter J, Skerka C, Zipfel PF
  Title
The Staphylococcus aureus protein Sbi acts as a complement inhibitor and forms a tripartite complex with host complement Factor H and C3b.
  Journal
PLoS Pathog 4:e1000250 (2008)
DOI:10.1371/journal.ppat.1000250
Reference
  Authors
Bokarewa MI, Jin T, Tarkowski A
  Title
Staphylococcus aureus: Staphylokinase.
  Journal
Int J Biochem Cell Biol 38:504-9 (2006)
DOI:10.1016/j.biocel.2005.07.005
Reference
  Authors
Rooijakkers SH, Ruyken M, Roos A, Daha MR, Presanis JS, Sim RB, van Wamel WJ, van Kessel KP, van Strijp JA
  Title
Immune evasion by a staphylococcal complement inhibitor that acts on C3 convertases.
  Journal
Nat Immunol 6:920-7 (2005)
DOI:10.1038/ni1235
Reference
  Authors
Rooijakkers SH, Wu J, Ruyken M, van Domselaar R, Planken KL, Tzekou A, Ricklin D, Lambris JD, Janssen BJ, van Strijp JA, Gros P
  Title
Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor.
  Journal
Nat Immunol 10:721-7 (2009)
DOI:10.1038/ni.1756
Reference
  Authors
Jongerius I, Kohl J, Pandey MK, Ruyken M, van Kessel KP, van Strijp JA, Rooijakkers SH
  Title
Staphylococcal complement evasion by various convertase-blocking molecules.
  Journal
J Exp Med 204:2461-71 (2007)
DOI:10.1084/jem.20070818
Reference
  Authors
Hair PS, Ward MD, Semmes OJ, Foster TJ, Cunnion KM
  Title
Staphylococcus aureus clumping factor A binds to complement regulator factor I and increases factor I cleavage of C3b.
  Journal
J Infect Dis 198:125-33 (2008)
DOI:10.1086/588825
Reference
  Authors
Higgins J, Loughman A, van Kessel KP, van Strijp JA, Foster TJ
  Title
Clumping factor A of Staphylococcus aureus inhibits phagocytosis by human polymorphonuclear leucocytes.
  Journal
FEMS Microbiol Lett 258:290-6 (2006)
DOI:10.1111/j.1574-6968.2006.00229.x
Reference
  Authors
Laursen NS, Gordon N, Hermans S, Lorenz N, Jackson N, Wines B, Spillner E, Christensen JB, Jensen M, Fredslund F, Bjerre M, Sottrup-Jensen L, Fraser JD, Andersen GR
  Title
Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus.
  Journal
Proc Natl Acad Sci U S A 107:3681-6 (2010)
DOI:10.1073/pnas.0910565107
Reference
  Authors
Ramsland PA, Willoughby N, Trist HM, Farrugia W, Hogarth PM, Fraser JD, Wines BD
  Title
Structural basis for evasion of IgA immunity by Staphylococcus aureus revealed in the complex of SSL7 with Fc of human IgA1.
  Journal
Proc Natl Acad Sci U S A 104:15051-6 (2007)
DOI:10.1073/pnas.0706028104
Reference
  Authors
de Haas CJ, Veldkamp KE, Peschel A, Weerkamp F, Van Wamel WJ, Heezius EC, Poppelier MJ, Van Kessel KP, van Strijp JA
  Title
Chemotaxis inhibitory protein of Staphylococcus aureus, a bacterial antiinflammatory agent.
  Journal
J Exp Med 199:687-95 (2004)
DOI:10.1084/jem.20031636
Reference
  Authors
Prat C, Bestebroer J, de Haas CJ, van Strijp JA, van Kessel KP
  Title
A new staphylococcal anti-inflammatory protein that antagonizes the formyl peptide receptor-like 1.
  Journal
J Immunol 177:8017-26 (2006)
DOI:10.4049/jimmunol.177.11.8017
Reference
  Authors
Bestebroer J, Poppelier MJ, Ulfman LH, Lenting PJ, Denis CV, van Kessel KP, van Strijp JA, de Haas CJ
  Title
Staphylococcal superantigen-like 5 binds PSGL-1 and inhibits P-selectin-mediated neutrophil rolling.
  Journal
Blood 109:2936-43 (2007)
DOI:10.1182/blood-2006-06-015461
Reference
  Authors
Chung MC, Wines BD, Baker H, Langley RJ, Baker EN, Fraser JD
  Title
The crystal structure of staphylococcal superantigen-like protein 11 in complex with sialyl Lewis X reveals the mechanism for cell binding and immune inhibition.
  Journal
Mol Microbiol 66:1342-55 (2007)
DOI:10.1111/j.1365-2958.2007.05989.x
Reference
  Authors
Chavakis T, Hussain M, Kanse SM, Peters G, Bretzel RG, Flock JI, Herrmann M, Preissner KT
  Title
Staphylococcus aureus extracellular adherence protein serves as anti-inflammatory factor by inhibiting the recruitment of host leukocytes.
  Journal
Nat Med 8:687-93 (2002)
DOI:10.1038/nm728
Reference
  Authors
Li M, Lai Y, Villaruz AE, Cha DJ, Sturdevant DE, Otto M
  Title
Gram-positive three-component antimicrobial peptide-sensing system.
  Journal
Proc Natl Acad Sci U S A 104:9469-74 (2007)
DOI:10.1073/pnas.0702159104
Reference
  Authors
Sieprawska-Lupa M, Mydel P, Krawczyk K, Wojcik K, Puklo M, Lupa B, Suder P, Silberring J, Reed M, Pohl J, Shafer W, McAleese F, Foster T, Travis J, Potempa J
  Title
Degradation of human antimicrobial peptide LL-37 by Staphylococcus aureus-derived proteinases.
  Journal
Antimicrob Agents Chemother 48:4673-9 (2004)
DOI:10.1128/AAC.48.12.4673-4679.2004
Reference
  Authors
Fraser JD, Proft T
  Title
The bacterial superantigen and superantigen-like proteins.
  Journal
Immunol Rev 225:226-43 (2008)
DOI:10.1111/j.1600-065X.2008.00681.x
Reference
  Authors
Yamaguchi T, Nishifuji K, Sasaki M, Fudaba Y, Aepfelbacher M, Takata T, Ohara M, Komatsuzawa H, Amagai M, Sugai M
  Title
Identification of the Staphylococcus aureus etd pathogenicity island which encodes a novel exfoliative toxin, ETD, and EDIN-B.
  Journal
Infect Immun 70:5835-45 (2002)
DOI:10.1128/IAI.70.10.5835-5845.2002
Reference
  Authors
Pazgier M, Hoover DM, Yang D, Lu W, Lubkowski J
  Title
Human beta-defensins.
  Journal
Cell Mol Life Sci 63:1294-313 (2006)
DOI:10.1007/s00018-005-5540-2
Reference
  Authors
Zhang Q, Mousdicas N, Yi Q, Al-Hassani M, Billings SD, Perkins SM, Howard KM, Ishii S, Shimizu T, Travers JB
  Title
Staphylococcal lipoteichoic acid inhibits delayed-type hypersensitivity reactions via the platelet-activating factor receptor.
  Journal
J Clin Invest 115:2855-61 (2005)
DOI:10.1172/JCI25429
Reference
  Authors
Lehrer RI
  Title
Primate defensins.
  Journal
Nat Rev Microbiol 2:727-38 (2004)
DOI:10.1038/nrmicro976
Related
pathway
fca04610  Complement and coagulation cascades
fca04660  T cell receptor signaling pathway
fca04662  B cell receptor signaling pathway
KO pathway
ko05150   
LinkDB

DBGET integrated database retrieval system