KEGG   PATHWAY: fca05320
Entry
fca05320                    Pathway                                

Name
Autoimmune thyroid disease - Felis catus (domestic cat)
Description
The classification of autoimmune throid disease (AITD) includes Hashimoto's thyroiditis (HT) or chronic autoimmune thyroiditis and its variants, Graves' disease (GD) and autoimmune atrophic thyroiditis or primary myxedema. HT is characterized by the presence of goitre, thyroid autoantibodies against thyroid peroxidase (TPO) and thyroglobulin (Tg) in serum and varying degrees of thyroid dysfunction. During HT, self-reactive CD4+ T lymphocytes (Th) recruit B cells and CD8+ T cells (CTL) into the thyroid. Disease progression leads to the death of thyroid cells and hypothyroidism. Both autoantibodies and thyroid-specific cytotoxic T lymphocytes (CTLs) have been proposed to be responsible for autoimmune thyrocyte depletion. In GD, the TSH-R is the most important autoantigen. Antibodies directed against it mimic the effects of the hormone on thyroid cells, TSH, stimulating autonomous production of thyroxine and triiodothyronine and causing hyperthyroidism. The presence of TSH-R-blocking antibodies that bind the TSH receptor in a similar fashion to the antibodies in patients with Grave's disease but that block rather than activate the receptor explains some cases of atrophic hypothyroidism.
Class
Human Diseases; Immune disease
Pathway map
fca05320  Autoimmune thyroid disease
fca05320

Organism
Felis catus (domestic cat) [GN:fca]
Gene
493648  IFNA8; interferon alpha-8 precursor [KO:K05414]
493653  IFNA7; interferon alpha precursor [KO:K05414]
101088440  interferon alpha-2-like [KO:K05414]
101081371  interferon alpha-like [KO:K05414]
493840  IFNA5; LOW QUALITY PROTEIN: interferon alpha-5 [KO:K05414]
111557596  interferon alpha-like [KO:K05414]
101088996  DRA; HLA class II histocompatibility antigen, DR alpha chain-like precursor [KO:K06752]
100169654  SLC26A3; chloride anion exchanger precursor [KO:K06752]
101098301  DLA class II histocompatibility antigen, DR-1 beta chain precursor [KO:K06752]
111556169  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
101082906  HLA class II histocompatibility antigen, DO beta chain isoform X2 [KO:K06752]
101084108  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
101088734  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
111556173  HLA class II histocompatibility antigen, DM beta chain-like isoform X1 [KO:K06752]
101090518  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
111560441  HLA class II histocompatibility antigen, DO beta chain-like isoform X1 [KO:K06752]
101090771  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
111560440  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
101082653  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
101090265  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
101084962  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
111560443  HLA class II histocompatibility antigen, DM alpha chain-like [KO:K06752]
111560444  HLA class II histocompatibility antigen, DO alpha chain-like [KO:K06752]
111560445  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
111556176  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
111558969  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
111558970  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
102899262  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
493743  CTLA4; cytotoxic T-lymphocyte protein 4 [KO:K06538]
101098706  TPO; thyroid peroxidase [KO:K00431] [EC:1.11.1.8]
101088550  TG; thyroglobulin [KO:K10809]
111559549  uncharacterized protein LOC111559549 [KO:K10785]
493786  CD80; T-lymphocyte activation antigen CD80 [KO:K05412]
493704  CD86; T-lymphocyte activation antigen CD86 precursor [KO:K05413]
493802  CD28; T-cell-specific surface glycoprotein CD28 precursor [KO:K06470]
751114  IL2; interleukin-2 precursor [KO:K05429]
101095479  FLAI-K; saoe class I histocompatibility antigen, A alpha chain-like precursor [KO:K06751]
105260551  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0101 alpha chain [KO:K06751]
101081297  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
101080790  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
111556177  HLA class I histocompatibility antigen, B-45 alpha chain-like isoform X1 [KO:K06751]
101099296  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
101094232  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
101080285  HLA class I histocompatibility antigen, Cw-12 alpha chain-like [KO:K06751]
493945  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
493881  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
100113473  PRF1; perforin-1 precursor [KO:K07818]
100127106  GZMB; granzyme B(G,H) [KO:K01353] [EC:3.4.21.79]
101099215  granzyme B-like [KO:K01353] [EC:3.4.21.79]
493850  CD40LG; CD40 ligand [KO:K03161]
101085363  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
751514  IL4; interleukin-4 precursor [KO:K05430]
493803  IL5; interleukin-5 precursor [KO:K05428]
493683  IL10; interleukin-10 precursor [KO:K05443]
493842  TSHR; thyrotropin receptor precursor [KO:K04249]
751819  CGA; glycoprotein hormones alpha chain precursor [KO:K08522]
554350  TSHB; thyrotropin subunit beta precursor [KO:K05251]
Compound
C01382  Iodine
C01829  Thyroxine
C02465  Triiodothyronine
D00636  Amiodarone hydrochloride (JP18/USP)
Reference
  Authors
Fountoulakis S, Tsatsoulis A.
  Title
On the pathogenesis of autoimmune thyroid disease: a unifying hypothesis.
  Journal
Clin Endocrinol (Oxf) 60:397-409 (2004)
DOI:10.1046/j.1365-2265.2004.01978.x
Reference
  Authors
Chistiakov DA.
  Title
Immunogenetics of Hashimoto's thyroiditis.
  Journal
J Autoimmune Dis 2:1 (2005)
DOI:10.1186/1740-2557-2-1
Reference
PMID:9534029
  Authors
McIver B, Morris JC.
  Title
The pathogenesis of Graves' disease.
  Journal
Endocrinol Metab Clin North Am 27:73-89 (1998)
DOI:10.1016/S0889-8529(05)70299-1
Reference
  Authors
Stassi G, De Maria R.
  Title
Autoimmune thyroid disease: new models of cell death in autoimmunity.
  Journal
Nat Rev Immunol 2:195-204 (2002)
DOI:10.1038/nri750
Reference
  Authors
Collins J, Gough S.
  Title
Autoimmunity in thyroid disease.
  Journal
Eur J Nucl Med Mol Imaging 29 Suppl 2:S417-24 (2002)
DOI:10.1007/s00259-002-0848-8
Reference
  Authors
Ruwhof C, Drexhage HA.
  Title
Iodine and thyroid autoimmune disease in animal models.
  Journal
Thyroid 11:427-36 (2001)
DOI:10.1089/105072501300176381
Reference
  Authors
Tsatsoulis A.
  Title
The role of stress in the clinical expression of thyroid autoimmunity.
  Journal
Ann N Y Acad Sci 1088:382-95 (2006)
DOI:10.1196/annals.1366.015
Reference
  Authors
Prummel MF, Strieder T, Wiersinga WM.
  Title
The environment and autoimmune thyroid diseases.
  Journal
Eur J Endocrinol 150:605-18 (2004)
DOI:10.1530/eje.0.1500605
Reference
  Authors
Kopp P.
  Title
The TSH receptor and its role in thyroid disease.
  Journal
Cell Mol Life Sci 58:1301-22 (2001)
DOI:10.1007/PL00000941
Related
pathway
fca04210  Apoptosis
fca04514  Cell adhesion molecules
fca04610  Complement and coagulation cascades
fca04612  Antigen processing and presentation
fca04660  T cell receptor signaling pathway
fca04662  B cell receptor signaling pathway
fca04918  Thyroid hormone synthesis
KO pathway
ko05320   
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