KEGG   PATHWAY: ffu00254
Entry
ffu00254                    Pathway                                
Name
Aflatoxin biosynthesis - Fulvia fulva
Class
Metabolism; Biosynthesis of other secondary metabolites
Pathway map
ffu00254  Aflatoxin biosynthesis
ffu00254

Other DBs
GO: 0045122
Organism
Fulvia fulva [GN:ffu]
Gene
CLAFUR5_06324  Acetyl-CoA carboxylase [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
CLAFUR5_14164  Norsolorinic acid synthase [KO:K15316] [EC:2.3.1.221]
CLAFUR5_14273  Monooxygenase hypC [KO:K17643] [EC:1.13.12.20]
CLAFUR5_14299  Norsolorinic acid ketoreductase nor1 [KO:K17644] [EC:1.1.1.349]
CLAFUR5_14300  5'-hydroxyaverantin dehydrogenase [KO:K17652] [EC:1.1.1.352]
CLAFUR5_14272  Versicolorin B synthase [KO:K17646] [EC:4.2.1.142 4.2.1.143]
CLAFUR5_14163  Cytochrome P450 monooxygenase cypX [KO:K24440] [EC:1.14.-.-]
CLAFUR5_09684  FAD-binding monooxygenase moxY [KO:K24855] [EC:1.14.13.-]
CLAFUR5_14161  FAD-binding monooxygenase moxY [KO:K24855] [EC:1.14.13.-]
CLAFUR5_06057  Versiconal hemiacetal acetate esterase [KO:K17648] [EC:3.1.1.94]
CLAFUR5_14256  Versiconal hemiacetal acetate esterase [KO:K17648] [EC:3.1.1.94]
CLAFUR5_02298  Averantin hydroxylase [KO:K24439] [EC:1.14.-.-]
CLAFUR5_14302  Versicolorin B desaturase [KO:K24439] [EC:1.14.-.-]
CLAFUR5_14375  Versicolorin reductase 1 [KO:K24856]
CLAFUR5_10127  Oxidoreductase aflX [KO:K24857]
CLAFUR5_14279  Oxidoreductase ordB [KO:K24857]
Compound
C00024  Acetyl-CoA
C00083  Malonyl-CoA
C00961  Sterigmatocystin
C03683  6-Demethylsterigmatocystin
C03686  O-Methylsterigmatocystin
C03944  Dihydro-O-methylsterigmatocystin
C06800  Aflatoxin B1
C16753  Aflatoxin B2
C16754  Aflatoxin G2
C16755  Aflatoxin G1
C20444  Dihydrodemethylsterigmatocystin
C20445  Dihydrosterigmatocystin
C20452  Norsolorinic acid
C20453  Norsolorinic acid anthrone
C20499  (1'S)-Averantin
C20500  (1'S,5'S)-5'-Hydroxyaverantin
C20501  (1'S,5'R)-5'-Hydroxyaverantin
C20502  5'-Oxoaverantin
C20503  1'-Hydroxyversicolorone
C20504  Versicolorone
C20505  Versiconal hemiacetal acetate
C20506  Versiconol acetate
C20507  Versiconal
C20508  Versiconol
C20574  (1'S,5'S)-Averufin
C20575  Versicolorin B
C20583  Versicolorin A
Reference
  Authors
Yu J
  Title
Current understanding on aflatoxin biosynthesis and future perspective in reducing aflatoxin contamination.
  Journal
Toxins (Basel) 4:1024-57 (2012)
DOI:10.3390/toxins4111024
Reference
  Authors
Yabe K, Nakajima H
  Title
Enzyme reactions and genes in aflatoxin biosynthesis.
  Journal
Appl Microbiol Biotechnol 64:745-55 (2004)
DOI:10.1007/s00253-004-1566-x
Reference
  Authors
Ehrlich KC
  Title
Predicted roles of the uncharacterized clustered genes in aflatoxin biosynthesis.
  Journal
Toxins (Basel) 1:37-58 (2009)
DOI:10.3390/toxins1010037
Reference
  Authors
Korman TP, Crawford JM, Labonte JW, Newman AG, Wong J, Townsend CA, Tsai SC
  Title
Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis.
  Journal
Proc Natl Acad Sci U S A 107:6246-51 (2010)
DOI:10.1073/pnas.0913531107
Reference
  Authors
Sakuno E, Wen Y, Hatabayashi H, Arai H, Aoki C, Yabe K, Nakajima H
  Title
Aspergillus parasiticus cyclase catalyzes two dehydration steps in aflatoxin biosynthesis.
  Journal
Appl Environ Microbiol 71:2999-3006 (2005)
DOI:10.1128/AEM.71.6.2999-3006.2005
Reference
  Authors
Shima Y, Shiina M, Shinozawa T, Ito Y, Nakajima H, Adachi Y, Yabe K
  Title
Participation in aflatoxin biosynthesis by a reductase enzyme encoded by vrdA gene outside the aflatoxin gene cluster.
  Journal
Fungal Genet Biol 46:221-31 (2009)
DOI:10.1016/j.fgb.2008.12.005
KO pathway
ko00254   
LinkDB

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