KEGG   PATHWAY: gas04115
Entry
gas04115                    Pathway                                
Name
p53 signaling pathway - Gracilinanus agilis (agile gracile opossum)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
gas04115  p53 signaling pathway
gas04115

Organism
Gracilinanus agilis (agile gracile opossum) [GN:gas]
Gene
123231037  TSC2; tuberin [KO:K07207]
123231913  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
123232226  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
123232391  [KO:K02187] [EC:3.4.22.56]
123233016  AIFM2; ferroptosis suppressor protein 1 [KO:K22745]
123233053  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
123233083  [KO:K10135]
123233411  TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722]
123234946  RRM2; ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
123235321  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
123235559  CCNG1; cyclin-G1 [KO:K10145]
123236114  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
123236307  [KO:K10134]
123236533  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
123237320  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
123237395  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
123237619  SIVA1; apoptosis regulatory protein Siva [KO:K22744]
123237918  THBS1; thrombospondin-1 [KO:K16857]
123238254  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
123238925  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
123238927  EI24; etoposide-induced protein 2.4 homolog [KO:K10134]
123239227  [KO:K08738]
123239305  RPRM; protein reprimo [KO:K10128]
123240075  [KO:K04398] [EC:3.4.22.61]
123240323  ZMAT3; zinc finger matrin-type protein 3 [KO:K10137]
123240403  SESN2; sestrin-2 isoform X1 [KO:K20394]
123240666  SESN3; sestrin-3 isoform X1 [KO:K10141]
123240740  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
123240973  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
123241475  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
123241957  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
123242291  STEAP3; metalloreductase STEAP3 [KO:K10142] [EC:1.16.1.-]
123242697  [KO:K04398] [EC:3.4.22.61]
123242888  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
123242961  PPP1R13L; relA-associated inhibitor [KO:K27356]
123243178  SFN; 14-3-3 protein sigma [KO:K06644]
123243797  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
123243800  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
123243938  MDM4; protein Mdm4 isoform X1 [KO:K10127]
123244534  TP53; cellular tumor antigen p53 [KO:K04451]
123244977  GORAB; RAB6-interacting golgin isoform X1 [KO:K19748]
123245045  SERPINE1; plasminogen activator inhibitor 1 isoform X1 [KO:K03982]
123245608  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
123245641  [KO:K10136]
123245905  COP1; E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
123246605  [KO:K06626]
123247699  SESN1; sestrin-1 isoform X1 [KO:K10141]
123247748  PPM1D; protein phosphatase 1D [KO:K10147] [EC:3.1.3.16]
123248687  BID; BH3-interacting domain death agonist [KO:K04726]
123248749  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
123248961  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
123249081  ZNF385A; zinc finger protein 385A isoform X1 [KO:K26543]
123249533  GTSE1; G2 and S phase-expressed protein 1 [KO:K10129]
123249650  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
123250427  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
123250560  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
123250609  [KO:K08738]
123250729  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
123250986  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 isoform X1 [KO:K10144] [EC:2.3.2.27]
123251065  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
123251284  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
123251583  CCNG2; cyclin-G2 [KO:K10146]
123251651  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
123251682  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
123251829  [KO:K06643] [EC:2.3.2.27]
123251883  [KO:K02187] [EC:3.4.22.56]
123251985  [KO:K06626]
123252074  [KO:K02187] [EC:3.4.22.56]
123252572  CD82; CD82 antigen [KO:K06509]
123253005  SERPINB5; serpin B5 [KO:K10139]
123253069  DDB2; DNA damage-binding protein 2 [KO:K10140]
123253673  [KO:K10140]
123255406  SHISA5; protein shisa-5 isoform X1 [KO:K10135]
123255551  [KO:K02187] [EC:3.4.22.56]
123255768  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
123255898  TP53I3; quinone oxidoreductase PIG3 [KO:K10133] [EC:1.-.-.-]
123256076  BBC3; bcl-2-binding component 3 isoform X1 [KO:K10132]
123256252  PIDD1; p53-induced death domain-containing protein 1 [KO:K10130]
123256922  CHEK2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
gas04110  Cell cycle
gas04210  Apoptosis
gas04218  Cellular senescence
KO pathway
ko04115   

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