KEGG   PATHWAY: gas04151
Entry
gas04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Gracilinanus agilis (agile gracile opossum)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
gas04151  PI3K-Akt signaling pathway
gas04151

Other DBs
GO: 0043491
Organism
Gracilinanus agilis (agile gracile opossum) [GN:gas]
Gene
123230419  YWHAH; 14-3-3 protein eta [KO:K16198]
123230523  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
123230621  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
123230622  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
123230817  [KO:K02583]
123230857  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
123230876  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
123230880  CD19; B-lymphocyte antigen CD19 [KO:K06465]
123230928  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
123230988  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
123231037  TSC2; tuberin [KO:K07207]
123231222  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
123231251  [KO:K05414]
123231252  [KO:K05414]
123231254  [KO:K05414]
123231307  RPS6; 40S ribosomal protein S6 [KO:K02991]
123231482  ITGA2; integrin alpha-2 [KO:K06481]
123231489  FGF10; fibroblast growth factor 10 [KO:K04358]
123231496  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
123231509  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
123231515  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
123231657  IL7; interleukin-7 isoform X1 [KO:K05431]
123231762  LAMA1; laminin subunit alpha-1 [KO:K05637]
123232032  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
123232066  EPOR; erythropoietin receptor [KO:K05079]
123232075  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
123232189  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
123232273  FGF22; fibroblast growth factor 22 [KO:K04358]
123232395  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
123232498  [KO:K11584]
123232515  [KO:K07828]
123233025  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
123233053  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
123233099  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
123233417  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
123233580  LAMA5; laminin subunit alpha-5 [KO:K06240]
123233581  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
123233618  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
123233624  LAMC3; laminin subunit gamma-3 [KO:K06247]
123233760  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
123233788  FGF18; fibroblast growth factor 18 [KO:K04358]
123233823  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
123233824  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
123233889  IL4; interleukin-4 [KO:K05430]
123233974  SOS2; son of sevenless homolog 2 [KO:K03099]
123234190  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
123234272  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
123234292  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
123234294  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
123234327  RET; LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
123234658  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
123234719  [KO:K16197]
123234833  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
123235041  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
123235210  TSC1; hamartin isoform X1 [KO:K07206]
123235321  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
123235393  TLR4; toll-like receptor 4 [KO:K10160]
123235395  TNC; tenascin [KO:K06252]
123235492  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
123235497  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
123235614  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
123235626  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
123235790  YWHAQ; 14-3-3 protein theta [KO:K16197]
123235857  PGF; placenta growth factor [KO:K16859]
123236127  ITGA11; integrin alpha-11 [KO:K06587]
123236227  EFNA5; ephrin-A5 [KO:K05462]
123236241  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
123236427  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
123236441  [KO:K06630]
123236476  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
123236652  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
123236735  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
123236829  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
123236876  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
123236931  BCL2L11; bcl-2-like protein 11 [KO:K16341]
123236988  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
123236992  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
123237008  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
123237147  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
123237246  PKN3; serine/threonine-protein kinase N3 [KO:K23692]
123237309  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
123237312  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
123237389  ANGPT4; angiopoietin-4 [KO:K05467]
123237395  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
123237421  SGK2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
123237438  PRLR; prolactin receptor [KO:K05081]
123237600  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
123237620  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123237637  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
123237685  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
123237744  [KO:K16197]
123237748  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
123237918  THBS1; thrombospondin-1 [KO:K16857]
123237937  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
123237952  FGF7; fibroblast growth factor 7 [KO:K04358]
123237978  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
123238040  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
123238083  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
123238248  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
123238254  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
123238765  [KO:K13304] [EC:2.7.11.1]
123239224  ITGA4; integrin alpha-4 [KO:K06483]
123239267  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
123239466  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
123239663  [KO:K09420]
123239826  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
123240150  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
123240288  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
123240305  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
123240553  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
123240604  FGF9; fibroblast growth factor 9 [KO:K04358]
123240740  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
123240795  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
123240922  [KO:K04273]
123240956  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
123240973  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
123240981  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
123241052  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
123241067  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
123241274  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
123241275  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
123241543  MYC; myc proto-oncogene protein [KO:K04377]
123241697  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
123241727  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
123241835  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
123241949  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
123242170  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
123242200  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
123242209  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
123242242  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
123242256  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
123242322  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123242326  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
123242350  ITGB5; integrin beta-5 [KO:K06588]
123242376  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
123242449  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
123242450  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
123242540  VEGFD; vascular endothelial growth factor D [KO:K05449]
123242569  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
123242587  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
123242629  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
123242630  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
123242713  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
123242724  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
123242727  FN1; fibronectin [KO:K05717]
123242758  IRS1; insulin receptor substrate 1 [KO:K16172]
123242760  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
123242831  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
123242834  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
123242892  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
123242968  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
123242984  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
123242998  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123243007  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
123243043  NTF4; neurotrophin-4 [KO:K12457]
123243269  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
123243649  ITGB4; integrin beta-4 [KO:K06525]
123243678  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
123243800  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
123243826  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
123243989  ITGA3; integrin alpha-3 [KO:K06482]
123244043  ITGA2B; integrin alpha-IIb [KO:K06476]
123244164  G6PC1; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
123244253  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
123244267  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
123244349  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
123244419  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
123244438  YWHAE; 14-3-3 protein epsilon [KO:K06630]
123244534  TP53; cellular tumor antigen p53 [KO:K04451]
123244679  [KO:K06276] [EC:2.7.11.1]
123244798  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
123244837  G6PC3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
123244840  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
123244853  EFNA1; ephrin-A1 [KO:K05462]
123245039  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
123245069  [KO:K16197]
123245114  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
123245162  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
123245170  [KO:K05462]
123245203  ARTN; artemin [KO:K25415]
123245229  TNR; tenascin-R [KO:K06252]
123245322  BRCA1; breast cancer type 1 susceptibility protein [KO:K10605] [EC:2.3.2.27]
123245333  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
123245383  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
123245460  PKN2; serine/threonine-protein kinase N2 [KO:K23691]
123245523  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
123245546  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
123245551  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
123245608  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
123245615  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
123245668  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
123245703  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
123245714  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
123245724  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
123245733  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
123245763  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
123245896  FASLG; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 6 [KO:K04389]
123245903  TNN; tenascin-N [KO:K06252]
123245918  LAMC1; laminin subunit gamma-1 [KO:K05635]
123245920  LAMC2; LOW QUALITY PROTEIN: laminin subunit gamma-2 [KO:K06246]
123245982  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
123245985  LAMB3; laminin subunit beta-3 [KO:K06244]
123246086  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
123246108  CRTC2; CREB-regulated transcription coactivator 2 [KO:K16333]
123246116  [KO:K04289]
123246163  CSF3; LOW QUALITY PROTEIN: granulocyte colony-stimulating factor [KO:K05423]
123246183  COL1A1; collagen alpha-1(I) chain [KO:K06236]
123246193  ITGB3; integrin beta-3 [KO:K06493]
123246198  [KO:K05438]
123246323  EPO; erythropoietin [KO:K05437]
123246360  TNXB; tenascin-X [KO:K06252]
123246427  VEGFA; vascular endothelial growth factor A [KO:K05448]
123246605  [KO:K06626]
123246710  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
123246760  ITGA9; integrin alpha-9 [KO:K06585]
123246908  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
123246932  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
123246971  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
123247019  THBS2; thrombospondin-2 [KO:K04659]
123247071  CREB3L4; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
123247110  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
123247194  NRAS; GTPase NRas [KO:K07828]
123247200  NGF; beta-nerve growth factor [KO:K02582]
123247251  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
123247337  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
123247386  VTN; vitronectin isoform X1 [KO:K06251]
123247388  CHAD; chondroadherin [KO:K06248]
123247425  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123247456  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
123247526  YWHAG; 14-3-3 protein gamma [KO:K16198]
123247585  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
123247690  THBS3; thrombospondin-3 [KO:K04659]
123247693  FOXO3; forkhead box protein O3 [KO:K09408]
123247744  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
123247783  [KO:K05462]
123247806  [KO:K06243]
123247891  LAMA2; LOW QUALITY PROTEIN: laminin subunit alpha-2 [KO:K05637]
123247938  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
123248452  RHEB; GTP-binding protein Rheb [KO:K07208]
123248489  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
123248584  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
123248587  HSP90B1; endoplasmin [KO:K09487]
123248684  KRAS; GTPase KRas isoform X1 [KO:K07827]
123248749  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
123248836  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
123248925  VWF; von Willebrand factor [KO:K03900]
123248941  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
123248944  ITGA5; integrin alpha-5 [KO:K06484]
123248961  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
123249320  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
123249336  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
123249349  [KO:K04079]
123249476  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
123249486  LAMB1; laminin subunit beta-1 [KO:K05636]
123249515  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
123249569  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
123249615  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
123249650  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
123249682  FGF6; fibroblast growth factor 6 [KO:K04358]
123249718  ITGB8; integrin beta-8 [KO:K06591]
123249769  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
123249770  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
123249806  ITGA8; integrin alpha-8 [KO:K06584]
123249807  [KO:K06243]
123249991  HGF; hepatocyte growth factor [KO:K05460]
123250048  FGF23; fibroblast growth factor 23 [KO:K22428]
123250075  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
123250135  KITLG; kit ligand [KO:K05461]
123250225  ITGB7; integrin beta-7 [KO:K06590]
123250253  COL2A1; collagen alpha-1(II) chain [KO:K19719]
123250333  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
123250353  [KO:K06238]
123250354  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
123250360  [KO:K05084] [EC:2.7.10.1]
123250369  IL2RA; LOW QUALITY PROTEIN: interleukin-2 receptor subunit alpha [KO:K05068]
123250370  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
123250404  [KO:K05414]
123250411  [KO:K05414]
123250422  [KO:K05414]
123250427  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
123250429  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
123250431  [KO:K05415]
123250621  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
123250666  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
123250729  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
123250743  NTF3; LOW QUALITY PROTEIN: neurotrophin-3 [KO:K04356]
123250763  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
123250969  FGF3; fibroblast growth factor 3 [KO:K04358]
123251011  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
123251014  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
123251051  AREG; amphiregulin [KO:K09782]
123251095  FGF19; fibroblast growth factor 19 [KO:K22603]
123251137  IL2; interleukin-2 [KO:K05429]
123251242  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
123251284  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
123251290  RELA; transcription factor p65 isoform X1 [KO:K04735]
123251373  BAD; bcl2-associated agonist of cell death [KO:K02158]
123251436  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
123251466  VEGFC; vascular endothelial growth factor C [KO:K05449]
123251496  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
123251504  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
123251511  [KO:K02991]
123251571  F2R; proteinase-activated receptor 1 [KO:K03914]
123251614  SPP1; osteopontin [KO:K06250]
123251640  THBS4; thrombospondin-4 [KO:K04659]
123251763  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
123251828  [KO:K07827]
123251829  [KO:K06643] [EC:2.3.2.27]
123251872  ITGA1; integrin alpha-1 [KO:K06480]
123251886  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
123251915  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
123251933  FGF5; fibroblast growth factor 5 [KO:K04358]
123251948  GHR; growth hormone receptor [KO:K05080]
123251985  [KO:K06626]
123252000  FGF20; fibroblast growth factor 20 [KO:K04358]
123252017  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
123252062  [KO:K06253]
123252239  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
123252361  [KO:K04382] [EC:3.1.3.16]
123252398  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
123252399  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
123252575  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
123252878  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
123252917  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
123252924  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
123252942  PDGFC; platelet-derived growth factor C [KO:K05450]
123253043  EREG; proepiregulin [KO:K09784]
123253141  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
123253515  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
123253639  FGF16; fibroblast growth factor 16 [KO:K04358]
123253770  [KO:K05096] [EC:2.7.10.1]
123253779  IKBKG; NF-kappa-B essential modulator [KO:K07210]
123253844  LAMA3; laminin subunit alpha-3 [KO:K06240]
123253939  [KO:K06630]
123254170  MTCP1; protein p13 MTCP-1 [KO:K16837]
123254622  [KO:K07825]
123254760  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
123254868  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
123254950  [KO:K05462]
123255090  [KO:K04358]
123255152  IL6; interleukin-6 [KO:K05405]
123255219  ANGPT1; angiopoietin-1 [KO:K05465]
123255401  [KO:K05084] [EC:2.7.10.1]
123255575  OSM; oncostatin-M [KO:K05418]
123255628  VEGFB; vascular endothelial growth factor B [KO:K16858]
123256030  FGF21; fibroblast growth factor 21 isoform X1 [KO:K22429]
123256044  INS; insulin [KO:K04526]
123256075  [KO:K06236]
123256513  [KO:K02649]
123256515  [KO:K02649]
123256602  PSPN; persephin [KO:K25416]
123256657  NRTN; neurturin [KO:K25414]
123256791  [KO:K04659]
123256825  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
gas00010  Glycolysis / Gluconeogenesis
gas04010  MAPK signaling pathway
gas04012  ErbB signaling pathway
gas04062  Chemokine signaling pathway
gas04064  NF-kappa B signaling pathway
gas04068  FoxO signaling pathway
gas04110  Cell cycle
gas04115  p53 signaling pathway
gas04150  mTOR signaling pathway
gas04210  Apoptosis
gas04370  VEGF signaling pathway
gas04510  Focal adhesion
gas04620  Toll-like receptor signaling pathway
gas04630  JAK-STAT signaling pathway
gas04662  B cell receptor signaling pathway
gas04910  Insulin signaling pathway
KO pathway
ko04151   

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