KEGG   PATHWAY: gas04380
Entry
gas04380                    Pathway                                
Name
Osteoclast differentiation - Gracilinanus agilis (agile gracile opossum)
Description
The osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways activated by RANK and immune receptors, whose ligands are expressed on the surface of osteoblasts. Signaling from RANK changes gene expression patterns through transcription factors like NFATc1 and characterizes the active osteoclast.
Class
Organismal Systems; Development and regeneration
Pathway map
gas04380  Osteoclast differentiation
gas04380

Other DBs
GO: 0030316
Organism
Gracilinanus agilis (agile gracile opossum) [GN:gas]
Gene
123230642  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
123230857  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
123231024  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
123231100  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
123231353  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
123231877  TMEM64; transmembrane protein 64 isoform X1 [KO:K26770]
123231942  TNFRSF11B; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 11B [KO:K05148]
123232074  ACP5; tartrate-resistant acid phosphatase type 5 isoform X1 [KO:K14379] [EC:3.1.3.2]
123232082  JUNB; transcription factor jun-B [KO:K09028]
123232293  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
123232952  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
123233242  [KO:K08009]
123233359  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
123233417  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
123233661  CYLD; ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
123233723  [KO:K06551]
123233824  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
123234289  BLNK; B-cell linker protein [KO:K07371]
123234292  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
123234542  IL1B; interleukin-1 beta [KO:K04519]
123234975  FOSL2; fos-related antigen 2 [KO:K09030]
123235754  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
123236247  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
123236271  IL1A; interleukin-1 alpha [KO:K04383]
123236476  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
123236876  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
123236954  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
123237042  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
123237139  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
123237194  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
123237274  [KO:K06551]
123237461  SQSTM1; sequestosome-1 isoform X1 [KO:K14381]
123237465  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
123237498  LCP2; lymphocyte cytosolic protein 2 [KO:K07361]
123237620  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123237804  FOS; proto-oncogene c-Fos [KO:K04379]
123237973  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
123238040  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
123238271  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
123239366  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
123239917  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
123239921  [KO:K06512]
123239922  [KO:K06512]
123239924  [KO:K06512]
123239963  FOSB; protein fosB isoform X1 [KO:K09029]
123240037  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
123240219  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
123240288  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
123240526  GAB2; GRB2-associated-binding protein 2 [KO:K08091]
123240813  LILRB3; leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512]
123240815  [KO:K06512]
123240818  [KO:K06512]
123240819  [KO:K06512]
123240820  [KO:K06512]
123240821  [KO:K06512]
123240822  [KO:K06512]
123240825  [KO:K06512]
123241763  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
123242151  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
123242249  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
123242322  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123242449  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
123242450  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
123242452  IFNGR2; interferon gamma receptor 2 [KO:K05133]
123242593  FHL2; four and a half LIM domains protein 2 isoform X1 [KO:K14380]
123242713  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
123242831  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
123242941  [KO:K06512]
123242945  [KO:K06512]
123242950  [KO:K06512]
123242957  RELB; transcription factor RelB isoform X1 [KO:K09253]
123242998  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123243036  [KO:K07992]
123243232  LCK; tyrosine-protein kinase Lck isoform X1 [KO:K05856] [EC:2.7.10.2]
123243617  [KO:K12560]
123243627  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
123243674  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
123243860  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
123243928  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
123244279  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
123244823  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
123245100  TNF; tumor necrosis factor [KO:K03156]
123245384  [KO:K12560]
123245414  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
123245523  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
123245714  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
123245763  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
123245866  [KO:K06463]
123246193  ITGB3; integrin beta-3 [KO:K06493]
123246222  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
123246373  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
123246402  TREM2; triggering receptor expressed on myeloid cells 2 [KO:K14378]
123246567  FYN; tyrosine-protein kinase Fyn [KO:K05703] [EC:2.7.10.2]
123246710  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
123247021  MITF; microphthalmia-associated transcription factor [KO:K09455]
123247136  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
123247425  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123247552  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
123247650  [KO:K04696]
123247656  JUN; transcription factor AP-1 isoform X1 [KO:K04448]
123247741  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
123247856  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
123247976  IFNGR1; interferon gamma receptor 1 [KO:K05132]
123248655  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
123249253  NCF4; neutrophil cytosol factor 4 [KO:K08012]
123249564  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
123249688  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
123250011  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
123250180  IFNG; interferon gamma [KO:K04687]
123250431  [KO:K05415]
123250637  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
123250672  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
123250724  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
123250968  FOSL1; fos-related antigen 1 isoform X1 [KO:K04502]
123251014  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
123251179  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
123251290  RELA; transcription factor p65 isoform X1 [KO:K04735]
123251329  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
123252235  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
123252239  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
123252892  TEC; tyrosine-protein kinase Tec [KO:K07364] [EC:2.7.10.2]
123252984  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147]
123253137  SPI1; transcription factor PU.1 [KO:K09438]
123253279  BTK; tyrosine-protein kinase BTK [KO:K07370] [EC:2.7.10.2]
123253779  IKBKG; NF-kappa-B essential modulator [KO:K07210]
123254560  [KO:K04449]
123254832  [KO:K06512]
123254940  [KO:K14377]
123255525  NCF1; neutrophil cytosol factor 1 [KO:K08011]
123255868  [KO:K06512]
123256028  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
123256157  [KO:K14377]
123256248  [KO:K06512]
123256278  [KO:K14377]
123256513  [KO:K02649]
123256515  [KO:K02649]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:16313349
  Authors
Takayanagi H, Sato K, Takaoka A, Taniguchi T
  Title
Interplay between interferon and other cytokine systems in bone metabolism.
  Journal
Immunol Rev 208:181-93 (2005)
DOI:10.1111/j.0105-2896.2005.00337.x
Reference
PMID:20392226
  Authors
Takayanagi H
  Title
New immune connections in osteoclast formation.
  Journal
Ann N Y Acad Sci 1192:117-23 (2010)
DOI:10.1111/j.1749-6632.2009.05303.x
Reference
PMID:19585227
  Authors
Nakashima T, Takayanagi H
  Title
Osteoimmunology: crosstalk between the immune and bone systems.
  Journal
J Clin Immunol 29:555-67 (2009)
DOI:10.1007/s10875-009-9316-6
Reference
PMID:18722561
  Authors
Caetano-Lopes J, Canhao H, Fonseca JE
  Title
Osteoimmunology--the hidden immune regulation of bone.
  Journal
Autoimmun Rev 8:250-5 (2009)
DOI:10.1016/j.autrev.2008.07.038
Reference
PMID:18451259
  Authors
Lorenzo J, Horowitz M, Choi Y
  Title
Osteoimmunology: interactions of the bone and immune system.
  Journal
Endocr Rev 29:403-40 (2008)
DOI:10.1210/er.2007-0038
Reference
PMID:17869613
  Authors
David JP
  Title
Osteoimmunology: a view from the bone.
  Journal
Adv Immunol 95:149-65 (2007)
DOI:10.1016/S0065-2776(07)95005-1
Reference
PMID:16313342
  Authors
Jimi E, Ghosh S
  Title
Role of nuclear factor-kappaB in the immune system and bone.
  Journal
Immunol Rev 208:80-7 (2005)
DOI:10.1111/j.0105-2896.2005.00329.x
Reference
PMID:12748652
  Authors
Boyle WJ, Simonet WS, Lacey DL
  Title
Osteoclast differentiation and activation.
  Journal
Nature 423:337-42 (2003)
DOI:10.1038/nature01658
Reference
PMID:17633024
  Authors
Darnay BG, Besse A, Poblenz AT, Lamothe B, Jacoby JJ
  Title
TRAFs in RANK signaling.
  Journal
Adv Exp Med Biol 597:152-9 (2007)
DOI:10.1007/978-0-387-70630-6_12
Reference
PMID:15122243
  Authors
Baron R
  Title
Arming the osteoclast.
  Journal
Nat Med 10:458-60 (2004)
DOI:10.1038/nm0504-458
Reference
PMID:17380158
  Authors
Takayanagi H
  Title
Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems.
  Journal
Nat Rev Immunol 7:292-304 (2007)
DOI:10.1038/nri2062
Reference
PMID:20703218
  Authors
Krum SA, Chang J, Miranda-Carboni G, Wang CY
  Title
Novel functions for NFkappaB: inhibition of bone formation.
  Journal
Nat Rev Rheumatol 6:607-11 (2010)
DOI:10.1038/nrrheum.2010.133
Reference
PMID:15817678
  Authors
Lee NK, Choi YG, Baik JY, Han SY, Jeong DW, Bae YS, Kim N, Lee SY
  Title
A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation.
  Journal
Blood 106:852-9 (2005)
DOI:10.1182/blood-2004-09-3662
Reference
PMID:18329366
  Authors
Shinohara M, Koga T, Okamoto K, Sakaguchi S, Arai K, Yasuda H, Takai T, Kodama T, Morio T, Geha RS, Kitamura D, Kurosaki T, Ellmeier W, Takayanagi H
  Title
Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.
  Journal
Cell 132:794-806 (2008)
DOI:10.1016/j.cell.2007.12.037
Reference
PMID:15546140
  Authors
Takayanagi H, Kim S, Koga T, Taniguchi T
  Title
Stat1-mediated cytoplasmic attenuation in osteoimmunology.
  Journal
J Cell Biochem 94:232-40 (2005)
DOI:10.1002/jcb.20316
Reference
PMID:18382763
  Authors
Jin W, Chang M, Paul EM, Babu G, Lee AJ, Reiley W, Wright A, Zhang M, You J, Sun SC
  Title
Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice.
  Journal
J Clin Invest 118:1858-66 (2008)
DOI:10.1172/JCI34257
Reference
PMID:16184196
  Authors
Bai S, Kitaura H, Zhao H, Chen J, Muller JM, Schule R, Darnay B, Novack DV, Ross FP, Teitelbaum SL
  Title
FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner.
  Journal
J Clin Invest 115:2742-51 (2005)
DOI:10.1172/JCI24921
Reference
PMID:12110142
  Authors
Takayanagi H, Kim S, Taniguchi T
  Title
Signaling crosstalk between RANKL and interferons in osteoclast differentiation.
  Journal
Arthritis Res 4 Suppl 3:S227-32 (2002)
DOI:10.1186/ar581
Related
pathway
gas04010  MAPK signaling pathway
gas04020  Calcium signaling pathway
gas04064  NF-kappa B signaling pathway
gas04151  PI3K-Akt signaling pathway
gas04630  JAK-STAT signaling pathway
KO pathway
ko04380   

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