KEGG   PATHWAY: gas04510
Entry
gas04510                    Pathway                                
Name
Focal adhesion - Gracilinanus agilis (agile gracile opossum)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
gas04510  Focal adhesion
gas04510

Other DBs
GO: 0005925
Organism
Gracilinanus agilis (agile gracile opossum) [GN:gas]
Gene
123230690  CAV3; caveolin-3 [KO:K12959]
123230857  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
123231093  EMP2; epithelial membrane protein 2 [KO:K26256]
123231155  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
123231336  SHC3; LOW QUALITY PROTEIN: SHC-transforming protein 3 [KO:K17448]
123231482  ITGA2; integrin alpha-2 [KO:K06481]
123231496  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
123231762  LAMA1; laminin subunit alpha-1 [KO:K05637]
123231861  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
123232107  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
123232312  [KO:K12757]
123232356  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
123232358  TLN1; talin-1 [KO:K06271]
123232459  CRKL; crk-like protein [KO:K04438]
123232944  VCL; vinculin isoform X1 [KO:K05700]
123232980  [KO:K05692]
123233053  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
123233204  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
123233372  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
123233446  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
123233503  [KO:K07836]
123233580  LAMA5; laminin subunit alpha-5 [KO:K06240]
123233581  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
123233623  RAPGEF1; rap guanine nucleotide exchange factor 1 [KO:K06277]
123233624  LAMC3; laminin subunit gamma-3 [KO:K06247]
123233760  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
123233823  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
123233915  ACTB; actin, cytoplasmic 1 [KO:K05692]
123233974  SOS2; son of sevenless homolog 2 [KO:K03099]
123234105  SHC4; SHC-transforming protein 4 [KO:K17449]
123234189  TLN2; talin-2 [KO:K06271]
123234190  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
123234220  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
123234292  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
123234452  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
123234757  [KO:K05692]
123234907  [KO:K05692]
123234910  [KO:K07836]
123235028  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
123235311  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
123235395  TNC; tenascin [KO:K06252]
123235420  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
123235449  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
123235857  PGF; placenta growth factor [KO:K16859]
123236127  ITGA11; integrin alpha-11 [KO:K06587]
123236829  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
123236876  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
123237064  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
123237207  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
123237408  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
123237465  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
123237544  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
123237620  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123237717  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
123237869  [KO:K04513]
123237871  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
123237916  [KO:K05735] [EC:2.7.11.1]
123237918  THBS1; thrombospondin-1 [KO:K16857]
123238040  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
123238083  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
123238254  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
123238271  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
123238976  [KO:K04393]
123238988  [KO:K16060]
123239224  ITGA4; integrin alpha-4 [KO:K06483]
123239370  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
123239461  [KO:K12757]
123239466  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
123239477  [KO:K12757]
123239969  [KO:K06274]
123239989  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
123240039  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
123240041  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
123240288  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
123240362  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
123240475  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
123240520  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
123240591  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
123240870  [KO:K16060]
123241052  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
123241067  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
123241274  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
123241296  [KO:K04393]
123241697  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
123241949  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
123242170  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
123242209  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
123242242  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
123242322  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123242334  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
123242350  ITGB5; integrin beta-5 [KO:K06588]
123242352  MYLK; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
123242376  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
123242540  VEGFD; vascular endothelial growth factor D [KO:K05449]
123242607  [KO:K05692]
123242629  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
123242630  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
123242727  FN1; fibronectin [KO:K05717]
123242760  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
123242831  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
123242998  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123243125  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
123243649  ITGB4; integrin beta-4 [KO:K06525]
123243855  [KO:K05692]
123243954  [KO:K05692]
123243989  ITGA3; integrin alpha-3 [KO:K06482]
123244043  ITGA2B; integrin alpha-IIb [KO:K06476]
123244057  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
123244269  [KO:K05692]
123244291  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
123244336  CAPN2; calpain-2 catalytic subunit isoform X1 [KO:K03853] [EC:3.4.22.53]
123244440  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
123244479  ACTG1; actin, cytoplasmic 2 [KO:K05692]
123244679  [KO:K06276] [EC:2.7.11.1]
123244798  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
123244865  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
123245039  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
123245096  PXN; paxillin [KO:K05760]
123245147  [KO:K12757]
123245229  TNR; tenascin-R [KO:K06252]
123245333  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
123245523  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
123245551  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
123245608  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
123245714  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
123245903  TNN; tenascin-N [KO:K06252]
123245918  LAMC1; laminin subunit gamma-1 [KO:K05635]
123245920  LAMC2; LOW QUALITY PROTEIN: laminin subunit gamma-2 [KO:K06246]
123245985  LAMB3; laminin subunit beta-3 [KO:K06244]
123246183  COL1A1; collagen alpha-1(I) chain [KO:K06236]
123246193  ITGB3; integrin beta-3 [KO:K06493]
123246360  TNXB; tenascin-X [KO:K06252]
123246427  VEGFA; vascular endothelial growth factor A [KO:K05448]
123246567  FYN; tyrosine-protein kinase Fyn [KO:K05703] [EC:2.7.10.2]
123246700  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
123246760  ITGA9; integrin alpha-9 [KO:K06585]
123246812  CRK; adapter molecule crk [KO:K04438]
123246871  [KO:K27392]
123246908  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
123246932  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
123247019  THBS2; thrombospondin-2 [KO:K04659]
123247236  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
123247251  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
123247386  VTN; vitronectin isoform X1 [KO:K06251]
123247388  CHAD; chondroadherin [KO:K06248]
123247425  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123247456  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
123247542  MYL10; myosin regulatory light chain 10 [KO:K12756]
123247581  [KO:K05692]
123247605  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
123247656  JUN; transcription factor AP-1 isoform X1 [KO:K04448]
123247690  THBS3; thrombospondin-3 [KO:K04659]
123247744  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
123247806  [KO:K06243]
123247891  LAMA2; LOW QUALITY PROTEIN: laminin subunit alpha-2 [KO:K05637]
123248545  CAV1; caveolin-1 isoform X1 [KO:K06278]
123248572  RAP1B; ras-related protein Rap-1b [KO:K07836]
123248584  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
123248925  VWF; von Willebrand factor [KO:K03900]
123248944  ITGA5; integrin alpha-5 [KO:K06484]
123249295  [KO:K04393]
123249320  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
123249444  EMP1; epithelial membrane protein 1 [KO:K26255]
123249464  RHOA; transforming protein RhoA [KO:K04513]
123249486  LAMB1; laminin subunit beta-1 [KO:K05636]
123249501  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
123249718  ITGB8; integrin beta-8 [KO:K06591]
123249769  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
123249770  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
123249806  ITGA8; integrin alpha-8 [KO:K06584]
123249807  [KO:K06243]
123249991  HGF; hepatocyte growth factor [KO:K05460]
123250075  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
123250082  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
123250225  ITGB7; integrin beta-7 [KO:K06590]
123250253  COL2A1; collagen alpha-1(II) chain [KO:K19719]
123250333  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
123250353  [KO:K06238]
123250354  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
123250370  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
123250427  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
123250437  CTNNB1; catenin beta-1 [KO:K02105]
123250477  ZYX; zyxin isoform X1 [KO:K06273]
123250498  PARVB; beta-parvin [KO:K06275]
123250499  PARVG; gamma-parvin isoform X1 [KO:K06275]
123250694  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
123250726  CAV2; caveolin-2 [KO:K12958]
123250729  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
123251179  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
123251262  [KO:K05692]
123251373  BAD; bcl2-associated agonist of cell death [KO:K02158]
123251466  VEGFC; vascular endothelial growth factor C [KO:K05449]
123251614  SPP1; osteopontin [KO:K06250]
123251640  THBS4; thrombospondin-4 [KO:K04659]
123251765  PARVA; alpha-parvin [KO:K06275]
123251872  ITGA1; integrin alpha-1 [KO:K06480]
123251954  [KO:K04514] [EC:2.7.11.1]
123252062  [KO:K06253]
123252087  [KO:K04514] [EC:2.7.11.1]
123252171  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
123252331  [KO:K05730]
123252332  [KO:K05730]
123252399  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
123252503  MYL5; myosin light chain 5 [KO:K12753]
123252806  [KO:K06269] [EC:3.1.3.16]
123252924  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
123252942  PDGFC; platelet-derived growth factor C [KO:K05450]
123253141  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
123253292  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
123253493  [KO:K04725] [EC:2.3.2.27]
123253573  [KO:K04437]
123253770  [KO:K05096] [EC:2.7.10.1]
123253844  LAMA3; laminin subunit alpha-3 [KO:K06240]
123254042  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
123254168  [KO:K19663] [EC:2.7.11.13]
123255143  [KO:K19663] [EC:2.7.11.13]
123255628  VEGFB; vascular endothelial growth factor B [KO:K16858]
123255869  [KO:K05726]
123256075  [KO:K06236]
123256107  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
123256513  [KO:K02649]
123256515  [KO:K02649]
123256791  [KO:K04659]
123256803  SHC2; SHC-transforming protein 2 [KO:K17447]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
gas04010  MAPK signaling pathway
gas04060  Cytokine-cytokine receptor interaction
gas04070  Phosphatidylinositol signaling system
gas04110  Cell cycle
gas04151  PI3K-Akt signaling pathway
gas04310  Wnt signaling pathway
gas04512  ECM-receptor interaction
gas04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

DBGET integrated database retrieval system