KEGG   Gracilinanus agilis (agile gracile opossum): 123238040
Entry
123238040         CDS       T07702                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
gas  Gracilinanus agilis (agile gracile opossum)
Pathway
gas01521  EGFR tyrosine kinase inhibitor resistance
gas01522  Endocrine resistance
gas04010  MAPK signaling pathway
gas04012  ErbB signaling pathway
gas04014  Ras signaling pathway
gas04015  Rap1 signaling pathway
gas04022  cGMP-PKG signaling pathway
gas04024  cAMP signaling pathway
gas04062  Chemokine signaling pathway
gas04066  HIF-1 signaling pathway
gas04068  FoxO signaling pathway
gas04071  Sphingolipid signaling pathway
gas04072  Phospholipase D signaling pathway
gas04114  Oocyte meiosis
gas04140  Autophagy - animal
gas04148  Efferocytosis
gas04150  mTOR signaling pathway
gas04151  PI3K-Akt signaling pathway
gas04210  Apoptosis
gas04218  Cellular senescence
gas04270  Vascular smooth muscle contraction
gas04370  VEGF signaling pathway
gas04371  Apelin signaling pathway
gas04380  Osteoclast differentiation
gas04510  Focal adhesion
gas04517  IgSF CAM signaling
gas04540  Gap junction
gas04550  Signaling pathways regulating pluripotency of stem cells
gas04613  Neutrophil extracellular trap formation
gas04620  Toll-like receptor signaling pathway
gas04650  Natural killer cell mediated cytotoxicity
gas04660  T cell receptor signaling pathway
gas04662  B cell receptor signaling pathway
gas04664  Fc epsilon RI signaling pathway
gas04666  Fc gamma R-mediated phagocytosis
gas04668  TNF signaling pathway
gas04720  Long-term potentiation
gas04722  Neurotrophin signaling pathway
gas04725  Cholinergic synapse
gas04726  Serotonergic synapse
gas04730  Long-term depression
gas04810  Regulation of actin cytoskeleton
gas04910  Insulin signaling pathway
gas04912  GnRH signaling pathway
gas04914  Progesterone-mediated oocyte maturation
gas04915  Estrogen signaling pathway
gas04916  Melanogenesis
gas04917  Prolactin signaling pathway
gas04919  Thyroid hormone signaling pathway
gas04921  Oxytocin signaling pathway
gas04926  Relaxin signaling pathway
gas04928  Parathyroid hormone synthesis, secretion and action
gas04929  GnRH secretion
gas04934  Cushing syndrome
gas04935  Growth hormone synthesis, secretion and action
gas05010  Alzheimer disease
gas05022  Pathways of neurodegeneration - multiple diseases
gas05034  Alcoholism
gas05132  Salmonella infection
gas05135  Yersinia infection
gas05160  Hepatitis C
gas05161  Hepatitis B
gas05163  Human cytomegalovirus infection
gas05164  Influenza A
gas05165  Human papillomavirus infection
gas05166  Human T-cell leukemia virus 1 infection
gas05167  Kaposi sarcoma-associated herpesvirus infection
gas05170  Human immunodeficiency virus 1 infection
gas05200  Pathways in cancer
gas05205  Proteoglycans in cancer
gas05206  MicroRNAs in cancer
gas05207  Chemical carcinogenesis - receptor activation
gas05208  Chemical carcinogenesis - reactive oxygen species
gas05210  Colorectal cancer
gas05211  Renal cell carcinoma
gas05212  Pancreatic cancer
gas05213  Endometrial cancer
gas05214  Glioma
gas05215  Prostate cancer
gas05216  Thyroid cancer
gas05218  Melanoma
gas05219  Bladder cancer
gas05220  Chronic myeloid leukemia
gas05221  Acute myeloid leukemia
gas05223  Non-small cell lung cancer
gas05224  Breast cancer
gas05225  Hepatocellular carcinoma
gas05226  Gastric cancer
gas05230  Central carbon metabolism in cancer
gas05231  Choline metabolism in cancer
gas05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:gas00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    123238040 (MAP2K1)
   04012 ErbB signaling pathway
    123238040 (MAP2K1)
   04014 Ras signaling pathway
    123238040 (MAP2K1)
   04015 Rap1 signaling pathway
    123238040 (MAP2K1)
   04370 VEGF signaling pathway
    123238040 (MAP2K1)
   04371 Apelin signaling pathway
    123238040 (MAP2K1)
   04668 TNF signaling pathway
    123238040 (MAP2K1)
   04066 HIF-1 signaling pathway
    123238040 (MAP2K1)
   04068 FoxO signaling pathway
    123238040 (MAP2K1)
   04072 Phospholipase D signaling pathway
    123238040 (MAP2K1)
   04071 Sphingolipid signaling pathway
    123238040 (MAP2K1)
   04024 cAMP signaling pathway
    123238040 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    123238040 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    123238040 (MAP2K1)
   04150 mTOR signaling pathway
    123238040 (MAP2K1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    123238040 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    123238040 (MAP2K1)
   04148 Efferocytosis
    123238040 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    123238040 (MAP2K1)
   04210 Apoptosis
    123238040 (MAP2K1)
   04218 Cellular senescence
    123238040 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    123238040 (MAP2K1)
   04540 Gap junction
    123238040 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    123238040 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    123238040 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    123238040 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    123238040 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    123238040 (MAP2K1)
   04660 T cell receptor signaling pathway
    123238040 (MAP2K1)
   04662 B cell receptor signaling pathway
    123238040 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    123238040 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    123238040 (MAP2K1)
   04062 Chemokine signaling pathway
    123238040 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    123238040 (MAP2K1)
   04929 GnRH secretion
    123238040 (MAP2K1)
   04912 GnRH signaling pathway
    123238040 (MAP2K1)
   04915 Estrogen signaling pathway
    123238040 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    123238040 (MAP2K1)
   04917 Prolactin signaling pathway
    123238040 (MAP2K1)
   04921 Oxytocin signaling pathway
    123238040 (MAP2K1)
   04926 Relaxin signaling pathway
    123238040 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    123238040 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    123238040 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    123238040 (MAP2K1)
   04916 Melanogenesis
    123238040 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    123238040 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    123238040 (MAP2K1)
   04726 Serotonergic synapse
    123238040 (MAP2K1)
   04720 Long-term potentiation
    123238040 (MAP2K1)
   04730 Long-term depression
    123238040 (MAP2K1)
   04722 Neurotrophin signaling pathway
    123238040 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    123238040 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    123238040 (MAP2K1)
   05206 MicroRNAs in cancer
    123238040 (MAP2K1)
   05205 Proteoglycans in cancer
    123238040 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    123238040 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    123238040 (MAP2K1)
   05230 Central carbon metabolism in cancer
    123238040 (MAP2K1)
   05231 Choline metabolism in cancer
    123238040 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    123238040 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    123238040 (MAP2K1)
   05212 Pancreatic cancer
    123238040 (MAP2K1)
   05225 Hepatocellular carcinoma
    123238040 (MAP2K1)
   05226 Gastric cancer
    123238040 (MAP2K1)
   05214 Glioma
    123238040 (MAP2K1)
   05216 Thyroid cancer
    123238040 (MAP2K1)
   05221 Acute myeloid leukemia
    123238040 (MAP2K1)
   05220 Chronic myeloid leukemia
    123238040 (MAP2K1)
   05218 Melanoma
    123238040 (MAP2K1)
   05211 Renal cell carcinoma
    123238040 (MAP2K1)
   05219 Bladder cancer
    123238040 (MAP2K1)
   05215 Prostate cancer
    123238040 (MAP2K1)
   05213 Endometrial cancer
    123238040 (MAP2K1)
   05224 Breast cancer
    123238040 (MAP2K1)
   05223 Non-small cell lung cancer
    123238040 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    123238040 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    123238040 (MAP2K1)
   05161 Hepatitis B
    123238040 (MAP2K1)
   05160 Hepatitis C
    123238040 (MAP2K1)
   05164 Influenza A
    123238040 (MAP2K1)
   05163 Human cytomegalovirus infection
    123238040 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    123238040 (MAP2K1)
   05165 Human papillomavirus infection
    123238040 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    123238040 (MAP2K1)
   05135 Yersinia infection
    123238040 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    123238040 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    123238040 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    123238040 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    123238040 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    123238040 (MAP2K1)
   01522 Endocrine resistance
    123238040 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:gas01001]
    123238040 (MAP2K1)
Enzymes [BR:gas01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     123238040 (MAP2K1)
Protein kinases [BR:gas01001]
 Serine/threonine kinases: STE group
  STE7 family
   123238040 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 123238040
NCBI-ProteinID: XP_044521271
LinkDB
Position
2:complement(571750875..571859862)
AA seq 393 aa
MPKKKPMPIQLNPTPDGSTINGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLIMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAIGRYPIPPPDSKELELMFGCPMEGDAAETSPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGI
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgatgcccattcagctgaacccgaccccggatggctccacgatt
aacgggaccagctcggccgagactaatcttgaggcactacagaagaaattggaggagctg
gaattggatgaacagcagcgtaagcgtctggaagcttttctcacccagaaacagaaagtg
ggcgagttgaaggatgatgactttgagaagattagtgaactgggagctggaaatggtggt
gtggtattcaaggtttcgcacaaaccctctggcctaatcatggcaaggaagctaattcac
ctggagataaagccagcaattcggaaccagattatacgggagctgcaagtcctgcatgag
tgtaactctccatatattgtggggttttatggggccttttacagcgatggagagatcagt
atttgcatggagcacatggatggtggatctttggatcaggtccttaagaaagctggaaga
attcctgagcagatcttggggaaagttagcattgctgtaataaagggtcttacatatctg
agagagaagcataagataatgcacagagatgtcaagccatccaatatcttggtgaactca
cgtggagagatcaagctttgtgactttggcgtcagtgggcagctgattgattctatggct
aactctttcgtggggacaaggtcctatatgtcgccagaaagactccagggaactcactac
tctgtacagtcggacatctggagcatggggctgtctttggtagagatggcaattggacga
tatcccattccaccaccggactccaaggagctagaactgatgtttggctgtccaatggag
ggagatgctgctgagacgtcaccacgaccaagaactcctgggaggcccctcagttcttat
ggaatggatagccggccacctatggcaatttttgagctgctggattacatagtcaatgag
cctcctccaaagctgcccagtggagtcttcagtctggaatttcaagattttgtgaataaa
tgcctaataaaaaatccagctgagagagctgatttgaagcaacttatggttcatgccttt
atcaagaggtctgatgccgaggaagttgattttgcaggttggctctgctccaccataggc
cttaaccagcctagcacaccaactcatgctgctggcatctaa

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