Garra rufa (doctor fish): 141348455 Help Entry 141348455         CDS       T11039                                  Symbol ryr3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism grf  Garra rufa (doctor fish) Pathway grf04020   Calcium signaling pathway grf04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:grf00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     141348455 (ryr3)    04020 Calcium signaling pathway     141348455 (ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:grf04040]     141348455 (ryr3) Ion channels [BR:grf04040]  Voltage-gated cation channels   Ryanodine receptor    141348455 (ryr3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 Ago_Mid DUF2207_C EF-hand_6 EF-hand_1 Motif Other DBs NCBI-GeneID:  141348455 NCBI-ProteinID:  XP_073708855 LinkDB All DBs Position 13:complement(26413251..26530422) Genome browser AA seq 4950 aa AA seqDB search MREDEVVLQCVAAIQKENRKFCLSAEGLGNRLCYLEPTSEAKYFPPDLCICNFVLEQSLS VRALQEMLAGQSGEGNPDHEQWRLIRRAAQGGGHRTLLYGHAILLRHSFSGMYLTCLKTS RSLTDKLSFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYLHLSI SNGSIQVDASFMQTLWNVQPTCSRSNVEVGFLLGGQVFRLFHGHDESLTIPGSEQSQEQQ RVVNYETGKGGSKARSLWRLEPLRISWSGSHIRWGQPFRLRHLSTGHYLGQTEDNGLILL DREKSDTRATAFCFRSSKEKIDSGPKRDIDGMGVAEIKYGDSVCFIMHASTGLWLSYQAP DAKSSRLGPLKRRAVLSLEGHMDDGLTLQLCQHEESRAARIIRNTTRLFTQFIRGLDGLN GEKTTDVTLPVCEVLETLNDLIVYFQQPDSELEHEEKQRQLRSLIKRQDLFKEEGMLTLV SHCIDRLNVYNSAAEFEELAGEEAGEAWKDILNLLYELLAALIRGNRTNCTQFSRKLDWL VSKLERLESSSGILEVLHCILIESPESLNIIQKAHIKSIISLLYKHGRNHKILDVLCSLC VCNGVAVRANQNFICDHLLPRRDLLLQTRLVNDVQSIRPNIFLGMSEGSAQYKKWYFELI IDQVDHYVTSEPTHLRVGWATTKGYAPYPGGGEGWGGNGSGDDLYSYSFDGLHLWSGRIP RAVASINQHLLNSDDVVSCCLDLGAPSMSFRINGQPVQGMFEDFNVDGFFFPVVSFSAGV KVRFLLGGRHGDFKFLPPAGYAPCYEALLPKEKMRVEPVKEYKRDLEGVRDLLGTTEFLS QASFIPVPVDTSQIVLPPHLENVRDKLAENIHELWGMNKIELGWMYGKVRDDNKRQHPCL VDFSKLPETEKNYNLQMSTETLKTLLALGCHVAQVNINAEDDLKKMKLPKNYMMANGYKP TPLDLSDVKLTPGQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNRRNPRLVPYALL DERTKKSNRDSLREAIRTLVGYGYFIDPPDQETAHSIEKEGIESIRLFRVEKTYAVKTGK WYFEFEALTGGDMRVGWARPGCRPDMELGLDDQSFVFDGYRGRRVHMGSHFFGRSWNKGD VVGCMINMEDKSMIFTLNGEILITNKGSELCFADFETEDGFIPVCSLGLSQIGRMNLGKD ASTFKYYTMCGLQEGFEPFAVNMNREVTMWFSKRLPTFVNVPEDHPHIEVTRIDGTVDTP PCLKVTHKTYGTQTSNDDMVCCRLSMPVEFHSGPRKITDINEVIAEDQRAKKDDGGKVDY GSITKYFYSVRVFAGQDPSSVWVGWVTPDYHFYSKHFSLSTVRTVTVTLGDERGRVHESV RRSNCYMVCAGDVVNSSTGRSNTDLEIGCTIDLASGLVSFTANGRDLPTAYQVEPNTKLF PAVFVQPTSPNLFQFEFPKIPDAMPLSSAIFKSLQRNPEPQCPPRLDVQTIVSVLWSRMP NTFLSVETARVSERHGWVVQCLEPLQMMAVHIPEENRCIDIMELSENEDLRQFHSHTLKL FCALCALGNNRVAHALCSHLDQSQLLYTIDNQYLTGQLREGFYDVLISIHLETGKEAHLM MNNEFIIPVTDETRSIRLFHDDSKRHSLPGVGLSTSLSPRLNFTPPCFITPKRDQPLFSP QIPLGTLKEKAISMLTEAVQGGGAHIRDPVGGSVEYQFVPILKVIGTLLIMGALTSEEVR TILLLIDPGVFGDSKEEEEQTTVVEQGAEKEEATSNEEKAVEAGEEESKEAKQAPKGLLE KSLPESVKRQMCELLHYFCDCELKQRIESIVAFSDDFVSKLQYNQKFRYNELMQALNMSA AVTAKKTREFRSPPQEQINMLLNFGAGDDCTCPEELQEELQSFHDDLRLHCGIPMEEEEE EQDTSLKGRLMSLVYKIKGRPQKTEEKPTEQEQAAPTNLKELISQTMVTWAQECKIQDPA LVRSMFSLLRRQYDGIGELLRALRKSYTISAKSVGDAINLLASLGQIRSLLSVRMGEEEG QLMIDGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKNKEIAFPKMVASCCRF LCYFCRISRQNQKAMFDHLSYLLENSSVGLACPAMRGSTPLDVAASSVMDNNSLALALEE PDLEKVVTYLAGCGLQNCPMLIARGYPDIGWNPIEGERYLSFLRFAVFVNGESVEENANV VVKLLIRRPECFGPALRGEGGQGLLAAMKEAIKISEDPALDLPNLPEGAAPIVGEDEEEE EVAHMGNSIMSFYSALIDLLGRCAPEMHLINKGKGEALRIRAILRSLVPTKDLVGIISIP LKMPVVNKDGTVTEPDMNASFCPEHKAPMVLFLDRVYGIDDQSFLMHLLEVGFLPDLRAS ASLETEVLRTTETALAMNRYIGSAVLPLLTRCAHLFAHTEHYATLVDSTLHTIYRLSKGR SLTKAQRDAIDECLLAICMHLRPSMLQQLLRRLVFDVPQLTEYCKMPIKLLTNHYEQNWK YYCLPTGLGSYGMASEEELHLTKKLFWGLFDALSQKKYDSELFKMAMPCLSAIAGAIPPD YVDSSPGSTLVKQASVDGQGNFDPQPINTANISLPEKLDYIASKFAEHSHEKWSSEKIAL GWTAGDKVDDKAKTHPLLKPYKALSEKERETYRYPVKETLKSMLAMGWNIERTKEGEAMF QQRETEKQRKISESSQGEFKPAPHDLENVVLSRELQAMVETVAENYHNIWAKKKKKELDS KGGGSHPLLVPYDTLTAKEKYRDREKAQELFKFLQVNGYAISRGLKDMEQDSSSMEKRIA YKFLKRLLNYVDSAQEFIAHLEALASSGKTEKSPHDQEIKFFAKVLLPLIDQYFKNHCLY FLSSPSISLSSSGYASNKEKEMITSLFCKLAALVRHRISLFGSDSTNMVSCLHILSRSMD FRTVMKSGSELVKAGVRAFFENAAEDLEKTLENLKLGKMGQSRTQMKGVTQIISYTSVAL LPILTVLFQHITQHQFGAELLLDDIQLSCYRILTSLYSLGTGKNIYVEKQLPVLGECLST LVGAMPVAFLESHLNMHNPQSVFNTKTPRERAILSMPDTVDEMCPEMPDLDGLMKDIGEI SESGARYTEMPQVIEVILPMLCNYLSYWWEKGPENSPDDANCCTTVTSEHLSLILGNILK ILNNNLGIENAPWMKRLAVYSQPIISKASPDLLKTHFLPTLEKLKKKTLKVVAEEELLRA ESRADTQEAELQILDEFAVLCRDLYAFYPMLIRYVDNNRSKWLKQPDSDSNELFKMVSEI FILWCKSHNFKREEQNFVVQNEINNLAFLIGDSKTKMSKSGGQDQERRGKKRRGELYSIQ TSLIVAAHKKMLPIGLNMCTPGDQELISLAKIRYSLKDTDDEVKDYLRKNLHLQEKSADP AVQWQLNLYRDVVVKTEGPPDPDQNVNRVQAISAAVYYLDQVELPLRNKKMVFQKLLSKQ RKRAVVACFRMAPLYNLPRHRSINLFLSGYQRLWIETEEYSFEEKLVQDLAVSTGLASVL PRVLCVPAGAFSAAECSAASTVPAKAREHVSARLMYSSWPVFSSAGYVTHYRPRHSSQGM HEFRLSLSSCHLTRKAVRFSTAVKTPMTVVEEEEEEEAEVQPDPLHQLILHFSHNALTER SFLEEDPLYIAYADMMAKSCAENEEEEEEEEGKEKTFEEKEMEKQKILYQQARLHARGAA EMVLQMISASKGRLGPMVTGTLKLGISILNGGNVLVQQKMLDYLKDKRDAGFFKGLSGLM MSCSVLDLNAFERQNKAESLGMVTEEGSINLRERGSKVLQNDDFTKDLFRFLQLLCEGHN NDFQNFLRTQTGNTTTVNIIISTVDYLLRLQESISDFYWYYSGKDVMDDAGQRNFSKALA VAKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKEL MDLQKDMVVMMLSLLEGNVVNGTIGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTTSDN FKEYDPDCKGLISKKEFQKSMDSQKQYTQSEIEFLLSCVDADENDMFNYKEFVERFHEPA KDIGFNVAVLLTNLSEHMPHDSRLSTFLDLAESVLSYFEPYLGRIEIMGGAKRIERVYFE ISESSRTQWEKPQVKESKRQFIFDVVNEGGESEKMELFVNFCEDTIFEMQLASQISEPDA AERPEEDEDEELHSLLEGLSEEEDASLESASAFTAACASVKKSMSNFRKMLTFKSMRKQF KKFRKLTIREMITGFFSFFWMLFTGFFKGIFGIIFGFFHIIWSSMFGGGLVEGAKNMKVT DILGNMPDPTQFGIHGDVLEAEKTESSELVVSADMVQMTGAGAEKLEADMVMDLLNPAVK KEGKHGAEPGLGDVCEVLTESSVPVEKKKSQVSTDPAEKPESEPEKADTENQEKEDKAKE VTPEEPAAEKPAPKAKQGSSKEEAPAFMASFFAGLEVYKTKMLNYLARNFYNLRFLALFV AFAINFILLFYKVTGEFEDEEEEEGSWGGEEEEGDEDDEGLEYFILQEGTGYMAPTLTFL AVLHTIISLLCVVGYYCLKVPLVVFKREKEIARKLEFDGLYITEQPSDDDIKGQWDRLVI ATPSFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKSALDFDPTEEAVVKEASLLSW LSSIDTKYHIWKMGVVLTDNSYLYLIWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTIL SSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDAPDMKCDDMMTCYLFHM YVGVRAGGGIGDEIEDPAGDPYELYRILFDITFFFFVIVILLAIIQGLIIDAFGELRDQQ EQVKEDMETKCFICGIGNDYFDRTPHGFETHTLQEHNLANYLFFLMYLINKDETEYTGQE SYVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14853 nt NT seq  +upstreamnt  +downstreamnt atgagggaagatgaggtggttctgcagtgtgtcgccgccattcagaaggagaaccgcaaa ttctgcctatcagcagagggactcggcaaccgcctgtgttatctagagcccacatcagag gcgaagtattttcctcctgacctatgcatctgtaactttgtactggagcagtcgctctca gtgcgggctctacaggagatgctcgccgggcagagcggtgaaggaaatcctgatcatgag caatggaggcttataagacgggctgcacagggaggtggacatcggacactgctctacggt cacgccatcctccttaggcattcctttagtggaatgtatctgacatgcctgaagacctcc aggtctctgacagacaaactgtcttttgatgttggccttcaagaggattcaactggggaa gcttgttggtggacaattcacccggcatccaagcagaggtcagagggtgagaaggtgcgc attggagatgacctcatcttggtcagcgtgtcctctgagaggtacctgcacctctccatc tccaatggaagcattcaagtggacgcttcattcatgcaaacactgtggaacgttcagcct acctgctccagaagcaacgtggaagtgggatttcttctgggtgggcaagtgtttcgcttg ttccatgggcacgatgagagcctcaccataccaggatcagagcaaagccaagagcaacag agagtggtgaactatgagaccggcaaaggaggatccaaggccaggtctttatggagactg gagcctcttcggataagctggagtgggagtcatatcagatggggtcagcctttccgcctg cgccatctctccaccggtcactacctgggccagacagaggacaatggcctgatattgctg gacagagaaaagtctgacaccagggcaacagccttctgtttccggtcaagcaaggaaaag attgactcaggcccaaagcgtgatattgatggtatgggggtcgcagagatcaaatacggt gattcggtctgcttcatcatgcatgcgtccacaggcctgtggttgtcctaccaggcgcct gatgccaaatcttctcgcctgggaccactgaagagaagggctgtcctgtctcttgagggc catatggatgacgggctgactctgcagctttgccagcatgaggagtcccgggcggctcgc atcattcgcaataccacccgcctcttcactcagttcatcaggggtctggatggtttgaat ggcgagaagactacagatgtgacactgcctgtgtgtgaagtgctggagacgctcaacgac ctcattgtgtacttccagcagcctgactctgagctcgaacatgaggagaaacagaggcag ctccgatctctcatcaagcgccaggatctcttcaaagaagagggaatgctaaccctggtt tcccactgcatcgatcgtctaaacgtgtacaacagtgccgctgagtttgaggagttagca ggcgaggaggccggagaggcctggaaggacattctcaacctcctgtatgagcttctggcc gccctgattcgaggcaacaggaccaactgcacacagttctctcgcaagctggattggcta gtcagcaagctagagcgactggagtcctcatcgggcattttagaggtgcttcattgtatc ctaattgagagtccagaatctctgaacatcatccagaaggcccacatcaaatccattatt tctctgctgtacaagcatggacgcaaccacaagattttagatgttctctgttccctgtgt gtctgcaatggtgtggcagtgagagccaatcagaatttcatctgtgaccacctgcttccc aggagagacctgctgctccagacacgattggtcaatgatgtccaaagtattagacccaac atcttcctgggcatgagtgagggctctgcacagtataagaaatggtactttgagctgatc atcgatcaagtagaccactatgtgaccagtgagcccacccaccttcgtgttggctgggcc accactaaaggctacgccccctatcctgggggtggagagggctggggaggaaacggttct ggtgacgatctttactcttacagttttgatgggcttcatctgtggtcagggcgaatccca cgggccgtggcctctattaaccagcacttgctgaattcagacgatgttgtgagttgctgc ctggatctgggagctcctagcatgtctttccgaattaacggtcagcccgttcaaggcatg tttgaagacttcaacgtagatggcttcttctttcccgtcgtcagtttctctgcaggggtc aaggtccgtttcttgttgggtggtaggcatggagactttaagttcctgcctccagcaggc tacgcaccatgttatgaagccctgctccccaaagaaaagatgcgtgtggagcctgtgaag gagtataaaagagacctggagggagtgagagatctgctgggcaccacagagttcctgtcc caggcttccttcattcctgttcctgttgataccagccagattgtcctgcctccacatctt gaaaatgtgcgggacaagttagcggaaaacatccatgagctctggggcatgaacaaaata gagcttggctggatgtatggcaaggtccgtgatgacaacaagagacagcacccttgtctt gttgacttctctaaactgccagaaacagaaaagaattataacctgcaaatgtcaactgaa actttgaagaccctacttgctttgggatgccatgttgcacaagttaatataaatgctgaa gacgacttgaaaaaaatgaaactccccaagaactacatgatggcaaatggttataaacct acaccgctggacctttctgatgtgaaactgacacctggtcaggaggttctagttgataaa ttggctgaaaatgctcataatgtttgggccaaagatcgcatcaaacaaggatggacctat ggtattcagcaggatttgaaaaaccgtcgtaatccacggctggtgccatatgctttatta gatgaacgcactaagaaatcaaaccgagacagtcttcgagaggccatccgtactctggtt ggatatggatatttcatagacccacctgatcaagagactgctcacagtattgagaaggag ggcattgaatccatccgtctcttccgtgtggagaagacctacgctgtgaagaccgggaag tggtattttgagtttgaggcgcttactggaggtgacatgcgggtgggctgggcacggccc ggatgcagacctgatatggaactgggactagatgaccagtccttcgtctttgatggctac aggggccgccgggttcatatgggcagtcatttctttgggaggtcctggaataaaggagat gtggtgggctgcatgatcaacatggaggacaaatccatgatattcaccctgaatggagag atcttaatcaccaacaaaggctctgagctctgctttgctgactttgaaactgaagatgga ttcatcccagtgtgcagcctaggtctttcccaaattggccgcatgaatttaggaaaagat gctagtacttttaagtactacactatgtgtggccttcaggagggctttgaaccctttgct gtcaacatgaatcgagaggtcacaatgtggttcagcaaacgcctgcctacgtttgttaat gtaccagaggaccacccccatattgaggttactagaatagatggcaccgtggacacgcct ccatgtctaaaagtaacacacaagacgtatgggacccagactagcaatgacgacatggtt tgttgtcgtctaagcatgcctgttgagttccactctggccctcggaagatcactgatatc aatgaggtgatcgctgaggaccaaagagctaagaaggacgatggaggcaaggttgattat ggcagcattacaaagtacttctactctgtgagagtgtttgctggacaagatccttcatcc gtttgggtgggctgggtgacaccagactaccacttctacagcaaacatttcagcctcagc acagttcgcacggtcactgtaacactgggagacgagcggggacgtgttcacgagagtgtg aggaggagtaattgttacatggtctgtgctggggatgttgtcaacagctccacaggccgt agtaacactgatctggagattggctgcaccatagatctggcctcaggcctggtctcattc actgccaatggcagagatctgcctactgcataccaggttgagcctaacactaagcttttc cctgctgtgtttgttcaacccacgagtcccaacctcttccagtttgagtttccaaaaatc ccagatgcaatgcccctgtcttcagccatctttaagagtttacaaagaaacccagagccc cagtgtcctcctcggctggatgtgcaaacaatcgtgtccgtgctgtggagcagaatgcct aacaccttcctgtcggtggagacggcccgtgtgagtgagaggcatggctgggtagtgcag tgtctggagcccctacagatgatggctgttcatatcccagaggagaacaggtgtatcgac atcatggaactatcagaaaacgaagatctacggcagtttcactctcacactttaaagctc ttctgtgccctatgcgccctgggcaacaaccgcgttgcgcacgccctctgtagccatctt gaccaatcgcagctcttgtacaccattgataaccagtacctgactggccagctgcgtgaa ggcttttacgatgtcctcatcagcatccacctggaaacaggcaaagaggcccatctcatg atgaacaatgagtttataatcccagtaacggatgagacgagaagcatccgcctcttccat gatgactctaaacgtcactctcttcctggtgtaggcttgagcacttcactgtcccctcgc ctcaacttcacccctccgtgtttcattacccctaagcgcgatcagcctcttttcagccca caaatccctctgggaaccctaaaggagaaagccatcagtatgcttacggaagccgtgcag ggtggaggcgcccacattcgagatcctgtgggtggaagtgttgagtatcagtttgtaccg attctcaaggtgattggcaccctgctaataatgggggcactgaccagtgaggaggtgagg accattctgcttctcattgaccccggtgtgtttggggacagtaaggaggaggaggaacag accacagtggtggaacagggagctgagaaagaggaggcaaccagtaatgaagagaaggct gtggaggctggagaggaagagagtaaagaggcaaagcaggctccaaaaggtcttctggag aaaagcttgcctgaatcggtcaaacggcagatgtgtgagctgctgcactatttctgtgac tgtgagctgaagcagcgcattgagtccatcgtggccttctcagatgattttgtgtccaag ttgcaatacaatcagaaattccgctacaatgagttgatgcaagccctcaacatgtcagct gctgtcactgccaaaaagacaagagagttccgctcacctcctcaagagcagataaatatg ttgttgaactttggtgctggtgatgattgcacctgccctgaggaactgcaagaggagctt caaagcttccatgatgacctgcgactacattgtggcatccctatggaagaggaagaagag gagcaggacacatctctgaaaggccgcctaatgtccctggtatacaagattaaagggcgt ccccaaaaaactgaggaaaaaccaacagagcaagaacaggctgctcctaccaacctgaag gagctgatatctcagactatggtcacctgggctcaggagtgcaagatccaagacccggca ctagtccgcagcatgttcagccttttgagaaggcagtatgacggcatcggtgagctgctc agggccttgaggaagagctacaccatcagtgccaagtctgtaggggacgcgatcaacctg ctagcctcactgggccagatccgttctctacttagcgtccgcatgggggaagaggagggc cagctcatgatcgatggcctcggggacatcatgaacaacaaagtgttttaccagcatcca aatctaatgcgtgttcttggcatgcatgagacagtaatggaggtcatggtcaatgttctg ggaggagacaagaataaggagattgccttccccaagatggtggccagctgttgtcgcttc ctgtgctacttctgtcgcatcagccgtcagaaccagaaggctatgtttgaccacctgagc tacctcctggagaacagcagtgtgggactggcatgcccagccatgagaggctccacacct ttagatgtggctgcctcctctgtgatggacaacaacagtttagctctggcacttgaggaa cctgatcttgagaaggtggtgacatatctggcaggctgtggcttgcaaaactgcccaatg ctcattgccaggggatacccagacattggctggaacccaatagaaggagagcgctatttg tcctttttacggtttgctgtctttgtcaatggtgaaagtgttgaagaaaacgctaatgta gtggtaaagcttttgatcaggcgtccggagtgttttggacctgctctcagaggagaggga ggacaaggtttactcgcagccatgaaggaagctattaagatctcagaagatcctgcttta gacttgcctaacttacccgagggggctgcaccaatcgtcggagaggatgaagaggaggag gaggtcgcccacatgggcaactctattatgtccttctactcagcccttattgatcttctt ggccgctgtgcacctgagatgcatcttataaacaaaggcaaaggtgaagcactgcgtatc cgtgccatcctccgttccttagttcccactaaggatttggttggaattatcagtattcct ctcaaaatgccggtcgtcaataaagatggcactgtgacagaaccagatatgaatgccagc ttctgtccagagcacaaggcgcccatggtgctgttcctggaccgtgtctatggtattgac gaccagagctttttgatgcacctgctggaggtgggcttcctgccagacctgcgagcatca gcctccctggagacggaagtgctcaggaccacagagacagccctggccatgaaccgctac attggatccgcagtgcttcctctgttgacccgctgcgcccatctgttcgcacacactgag cactacgcgacgctcgttgactctacgctgcacaccatctatcgcctctcaaagggccga tcactcaccaaggcccagagagatgctattgatgaatgtctactggccatctgcatgcat ctccggccatcaatgctacagcaacttttgcgtcgtcttgtgtttgatgttccacagctt acagagtactgcaaaatgcccattaagctgttgaccaatcactatgagcagaactggaag tactactgtctgccaacaggcctgggcagctacggaatggcatcagaggaggaactccac cttaccaagaaactcttctggggactttttgatgctctttctcaaaagaaatatgattct gagcttttcaaaatggccatgccgtgtctgagtgccatagctggtgccataccacccgac tacgtcgactccagcccaggttccacattagttaagcaggcctctgtggatgggcaaggc aacttcgacccccagcctattaacactgctaacatctcgctgcctgaaaagctagattac attgcaagcaagtttgcagagcattcccatgagaaatggtcctctgagaagatcgctctc ggctggactgcgggagataaagtagatgacaaagctaaaactcatccacttctaaaaccg tacaaagcactgagtgaaaaggaaagggagacgtaccgctatcctgtgaaagagactctg aagagcatgttggcaatgggatggaacattgagaggaccaaagaaggggaagccatgttc cagcaacgggaaacggaaaaacagcgcaagatatcagagtcctctcagggtgagtttaag ccagccccacacgatttggaaaatgttgttctatcaagagaactacaggcgatggttgaa acagttgcagaaaattaccacaacatttgggcaaagaagaagaagaaggagcttgacagt aaaggaggaggaagtcatccattgttggtaccatatgacacacttacggcaaaggagaaa tacagagatcgagagaaggcccaggaactctttaaattcctgcaggtcaacggatacgcc attagcagaggtctaaaggatatggagcaggattcctcttctatggaaaagaggatcgcc tataagttcctcaagaggctcttgaattatgtagactctgcacaggagtttatcgcccat cttgaggctttggcttccagtgggaagacagaaaaatctccccatgatcaagagatcaag ttttttgctaaggttctgctgcccctcatagaccagtacttcaaaaaccactgcttgtac ttcctgtcatcccccagcatcagcctgagcagcagtggctacgcatccaacaaagagaag gagatgatcacaagtctgttctgtaagctggcagcccttgtcagacatagaatatcactc tttggaagtgactccaccaacatggtgagctgcttgcacatcctgtcacgctcaatggac tttaggactgtgatgaagtctggctcagagctggtaaaggctggtgtcagggcgttcttc gagaatgcagcggaagacctagagaagactctggagaacttgaagctggggaagatgggt cagtcacgcacccagatgaagggcgttacccagatcatcagttacacctcagtggccctg ctgcccatcctgacggttctctttcagcatatcacccagcaccagtttggagcagaactg ctattggatgacattcagctatcctgctaccgcatcctgaccagcctctactcgttgggc actggcaaaaacatctatgtggaaaaacagcttccagtgctgggtgaatgtttatctact cttgttggagccatgcctgttgccttcctggaatcccacctaaatatgcacaacccccaa tctgtcttcaacaccaagacaccaagagaacgagctattttgagcatgccagacactgtg gatgagatgtgtcctgagatgcctgatctggacggcctgatgaaggacatcggtgaaatt tctgaatccggagcacgctacacagagatgccacaggtcatcgaggtcatcctgcccatg ttgtgtaactacctgtcttactggtgggaaaaaggcccagaaaactccccagatgatgcc aactgctgcacaactgtcacatctgagcatcttagcctaatcctgggcaatatcctcaag attctcaataacaaccttggcattgaaaacgccccatggatgaaaagacttgcagtatat tcccagcctatcattagcaaggctagcccagatctccttaaaacacacttcctgccaacg ttggagaaactgaagaagaagacattaaaggttgtggctgaggaggagctgctgagggct gaaagcagggcagacactcaggaagctgaactgcagattttggatgagtttgctgttctc tgcagggatctgtacgccttctatccaatgctcattcgctatgtggacaacaacagatcc aaatggctgaagcaaccagattcggattcaaatgaacttttcaaaatggtgtcagagatt tttattctttggtgtaaatctcataactttaaaagggaagagcagaattttgtggtgcaa aatgaaatcaacaaccttgcgttcctcattggagacagcaagacgaagatgtcaaaatct ggaggtcaggaccaagagagaagaggaaaaaagagaagaggagagttgtactccatccag acttcccttatcgtagcagctcacaagaagatgttgcccattggtctgaacatgtgcacc cctggagaccaggagctcatttcccttgctaagatccgttatagtctaaaagacacagat gatgaggttaaagattacctgagaaagaacctccatcttcaggagaagtcagcagatcca gcagtgcagtggcagctgaacctctacagagatgttgtggtgaagactgagggacctcca gacccagaccaaaatgtgaatagagttcaggccatctccgctgctgtctattatcttgac caggttgagctgccgctgaggaacaagaagatggtgtttcaaaagctgctgtcaaagcaa agaaagcgtgccgtggtggcctgtttccgcatggcaccactctacaatttaccaaggcat cgctcaattaacctcttcctcagtggctatcagagactttggatagagacagaggagtac tcctttgaggagaagctagtgcaggacctggcagtaagtaccgggctggcatcagtgctg ccccgtgtgctgtgtgtgcccgctggtgccttctcggcggccgaatgctctgcggccagc accgtgcccgctaaggcgcgggagcacgtctctgcccgcctcatgtactcatcctggcct gtgttcagctctgctggttacgtgacacactaccgaccgaggcacagcagccaaggcatg catgagtttcggctgagcctcagttcctgccatctcactagaaaagctgtccgtttcagc acagccgtgaaaactcccatgactgtggtagaggaagaagaggaagaagaagctgaagtt cagccagaccctcttcatcagctcatccttcacttcagtcataatgctttgacagagaga agtttcctggaagaggatcctctctacattgcatatgctgacatgatggcaaagagctgt gccgagaatgaggaagaagaggaagaagaggagggaaaagaaaaaacgtttgaggaaaaa gaaatggagaagcagaagattctgtaccagcaggccagacttcatgcacgaggggctgct gagatggtgctacagatgatcagcgccagtaaaggccgacttggtcctatggtcactggc acccttaaactgggcatttctatcctaaatggaggcaatgttcttgtccagcagaaaatg ctggattatttgaaggataaacgagatgcgggcttctttaaaggtttatctggactaatg atgtcttgcagtgtgctggatttgaatgcatttgaaaggcaaaataaggcagaaagtctt ggaatggtgactgaagaggggtcaatcaacctgagagagcggggttccaaagtgctacaa aatgatgactttacaaaggatttattcaggtttttgcaactcctatgcgaggggcacaat aatgatttccaaaactttttgcggacccaaactggaaacactactacagtcaatatcatt attagcactgtggactacctattacgtctacaggaatctataagtgatttctactggtat tactctgggaaagatgtcatggatgacgctgggcaacgtaacttctctaaagctttggca gtagccaaacaaatctttaactcactcactgagtatattcagggcccttgtattgggaat cagcaaagtttggcacacagcaggttgtgggatgcagtggtcgggttcctgcatgttttt gcaaacatgcaaatgaaactgtcacaggattctagtcaaattgagttattgaaagagctg atggatttgcagaaagatatggtggtcatgatgttatctcttctggagggtaatgtggtg aatggaactatcggcaagcagatggttgacacattagtggagtcttccagcaatgtggaa atgatccttaaattcttcgacatgttcctcaaactgaaggacctcactacatctgataac ttcaaggagtacgacccagactgcaaaggccttatttccaagaaggagttccagaaatct atggatagccaaaagcaatacacacagtctgagatcgagtttctactctcctgtgtggat gcagatgaaaacgacatgttcaactacaaagagtttgtagaacgcttccatgagccagcc aaggacatcggcttcaacgtggctgtgcttcttactaacctatcagaacatatgcctcac gattcccgcctgtccactttcttagacctggctgaaagcgttcttagttactttgagcca tacttgggccgtattgagatcatgggaggtgccaagagaattgagagggtgtactttgag atcagcgagtctagcagaacccaatgggagaaacctcaggtcaaagagtccaaacggcag ttcatcttcgatgtggtcaacgaaggtggtgagagcgagaagatggagttgtttgtgaac ttctgtgaggacaccatctttgagatgcagttagcctctcagatctcagagccagatgcc gcagaacgacctgaggaggacgaagacgaggagttgcacagtctgctcgaaggattgtct gaggaagaagacgcatctctcgagtccgcctcagccttcacagcagcctgtgcctctgtg aagaaaagcatgtctaatttccgtaaaatgctgacatttaagagtatgaggaagcagttt aagaaattcaggaagctgaccatcagggaaatgatcacagggttcttctccttcttctgg atgctcttcaccggtttcttcaaaggcatcttcggcatcatcttcgggttctttcatatt atttggtcctccatgtttggagggggtcttgtggagggtgctaaaaacatgaaagtgact gatatcttgggtaacatgcctgatccaacacagtttgggatccatggtgatgtactggaa gcagaaaaaaccgaaagcagtgagttggtggtttctgcagatatggtgcagatgaccggt gctggtgctgagaagctagaggcggatatggtcatggatctacttaatccagctgtgaag aaggaagggaagcatggggcagaacctggtctgggtgatgtctgcgaagtcctgacagag tctagtgtccctgttgagaaaaagaagagccaggtatctacagacccagcagagaagcca gaatctgagccagagaaagctgacactgagaatcaggagaaagaagacaaggctaaagag gtaacacctgaggaaccagcagcagaaaaaccagctccaaaagccaaacaaggctcatca aaggaagaagctccagcattcatggccagcttctttgcaggccttgaagtctacaaaacc aaaatgctgaactacctggctcgcaatttctacaaccttcgttttctggctttgtttgtg gccttcgccatcaacttcatcctgctcttctacaaggtgactggagaatttgaagatgag gaagaggaggagggatcctggggtggtgaagaggaggaaggcgatgaagatgatgaagga ctggagtacttcattcttcaggagggcactggctacatggcacccacgttgacgtttttg gctgtactgcacacgatcatctctttactctgtgttgttggatactactgccttaaggtt cctttggttgtgttcaagcgggagaaggagattgctaggaagcttgagtttgacggtttg tatattaccgagcagccatctgatgatgacattaaaggacagtgggatcgtttggtcatc gcaactccgtctttccctaacaattactgggacaaatttgttaagaggaaggtcatcaat aaatatggtgatctgtatggggctgagcgcattgctgagctcctgggtctggataagagt gctctagactttgatcccaccgaagaggctgtggtgaaggaagcctccctgctgtcctgg ttgagctcaattgataccaagtaccacatctggaaaatgggcgtggtgctgacagacaac tcttacctctacctgatttggtacaccaccatgtctattctgggacattacaataacttc ttctttgctgctcatttgctggacattgccatgggcttcaagaccttgaggaccattctc tcttctgtgactcacaatggcaaacagctggtgttgaccgtgggcctgctagcggtcgtg gtctacctgtacaccgtggtggcttttaacttcttccgcaagttttacaacaagagcgag gatgaggacgcacctgacatgaagtgtgacgacatgatgacctgctacctgttccacatg tacgtgggtgtgagagctggcggtggcatcggtgatgaaatcgaagacccggccggtgac ccgtatgagctctaccgtatcctgtttgacatcaccttcttcttctttgttatcgtcatt ctgctggccatcattcagggtttgattattgatgcctttggtgagttgagagaccagcag gagcaggtgaaagaggacatggagacaaaatgcttcatctgtggaatcgggaacgactat tttgacagaactccgcacggctttgagacccataccttacaagagcacaatctggccaac tatttattcttcctgatgtatctgatcaacaaagatgagactgaatacactggtcaggag tcgtatgtttggaagatgtatcaggagaggtgctgggatttcttccctgctggagactgc ttccggaagcaatacgaggaccagctgggctag

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