Hippocampus comes (tiger tail seahorse): 109523744 Help Entry 109523744         CDS       T04969                                  Symbol ryr3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism hcq  Hippocampus comes (tiger tail seahorse) Pathway hcq04020   Calcium signaling pathway hcq04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:hcq00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     109523744 (ryr3)    04020 Calcium signaling pathway     109523744 (ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:hcq04040]     109523744 (ryr3) Ion channels [BR:hcq04040]  Voltage-gated cation channels   Ryanodine receptor    109523744 (ryr3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  109523744 NCBI-ProteinID:  XP_019738677 LinkDB All DBs Position Unknown AA seq 4837 aa AA seqDB search MAEGGDGEDEIQFLRTDDEVVLQSVATIQKEHRKFCLAAEGLGNRLCYLEPTSEAKYVPP DLCICNFVLEQSLSVRALQEMLANTGQSSEGAGQGGGHRTLLYGHAILLRHSFSGMYLTC LKTSRSLTDKLSFDVGLQQDAIGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSTERYL HLSISNSNIQVDASFMQTLWNVQPTCSSSNMAVGYLVGGHVMRLCRGHDESLTIPGAERS EEEQRIVNYEAGKGASKARSLWILEPLRISWSGSHIRWGQGFRLRHLSTGHYLALTEDRG LVLQDRERSDTTATSFCFRPSKEKSESGPKRDIDGMGVPEIKYGDSVCFIMHVATGLWLS YQAPDAKSSRLGPMKRRACLHSEGHMDDGLTLQRCQHEESQAARNIRNTTFLFTNFIKAL DSTATGVSMEVAGYVQEVLQMLNDLIEYFKQPDSELEHEEKQCLLRSLIKRQDLFKEEGM LALLSKCIDRMNLYNSAAHFGEMAGEEAGAAWKDILNLLYELLAALIRGNRNNCTQFSRN LDWLVSKLERLESSSGILEVLHCVLIESPEALNIIQRGHIKSIISLLCKHGRNHKILDVL CSLCVCNGVAVRANQNLICDNLLPKRDLLLQTRLVNDVHSMRPNIFLGVAEGSAQYKKWY FELVVDQVDHFVTAESTHLRVGWANTKGYAPYPGGGEGWGGNGVGDDLYSYSFDGLHLWS GRIPRAVASINQHLLTSDDVVSCCLDLGSPSMSFRINGQPVQGMFEDFNTDGFFFPVISF SAGVKVRFLLGGRHGDFKFLPPSGYSPCYEALLPKEKMYVEPVKEHKRDHDGVQDLLGTT QFLSQASFIPTPVDTSQIVLPPHMDNIRDKLAENIHELWGMNKIELGWTYGKIRDDNKRQ HPCLVDFAKLPETERNYNLQMSSETLKTLVALGCHVAQVNIHAEDDLKKIKLPKDYMMSN GYKPAPLDLSDVKLTARQEVLVEKLAENAHNVWAKDRIKQGWTYGIQQDLKNRRNPRLVP YALLDERTKKSNRDSLREAVRTMVGYGYDIDPPDQETVHVTDNQRIETLRFFRVEQTYAV KRGKWYFEFEALSGGDMRVGWARPGCRPDVELGTDDQAFVFDGYRARRLHAGSRYFGHLW KRGDVVGCMINMQDKSIIFTLNGELLITNKGSELCFTDFEAEDGFIPVCSVGMSQVGRMN LGKDASTFKYYTMCGLQEGFEPFAVNMNREITMWFSKRLATFVNVPQGHRDIEVTRIDGT VDSPPCLKVTHKTFGTQNSNNEMIYCRLSMPVEFFPADMLLDESFPLSHPPKSDGATDYG RITTYYHSVRVFAGQDPASVWVGWVTPDYHYYSKNFSLTNTRTVTVTLGDERGRVHESVQ RSNCYMVCGAEAIGPSSSSRSNSDVEIGCLLDLATGLVSFTANGKELSTTYQVEPSTKLF PAVFVRPTCVNLFQFEFVKIKDAMPISSAIFKSEHRNPVPQCPPRLNVQTIVAVLWSRMP NTFLSVETARVSERHGWVVQCLEPLQMMAVHIPEENRCLDILELSEHEDLRKFHYHTLKL YCALCALGNTRVAHALCSHLDQSQLLYTIDNQYLSGMLREGFYNVLISIHLETAKEARLM MNNEFIIPVTDETRSIKLFPDESKKHSLPGVSLSTSLKPRVNFSPACIISIKRQQYLHSP QIPLGILKEKAINMLSEAVQGGGIHIRDPVGGSVEYQFVPILKLIGTLLIMGVLNSEEVR LILLLIDPNVFGEVEEAKVEEGAVTRKTEEVSTSAEKSTEAGEEETKENKASVRGLLEKS LPESVKRQMCELLHYFCDCELKQRIEAIVSFSDNFVSKLQHNQKFRYNELMLALNLSAAI TAKKTKEFRSPPQEQINILLNFTAGDDCPCPEDLQEELKAFHEELQLHCGIPVEEDEDEQ DTSIKGRLLALLYKIKGPPQKMEEEPEEKEQASPTNLKELISQTITTWAQETHMQDPELV RVMFSLLRRQFDGIGELLRAMKKSYTISAASVQDAINLLASLGQIRSLLSVRMGIEEEKL MIDGLGNIMNNKVFYQHPNLMRVLGMHETVMQVMVNVLGGDKSQEIAFPKMVASCCRFLC YFCRISRQNQKAMFDHLSYLLENSSVGLASEAMRGSTPLDVAASSVMDNNGLALALEEPD LEKVVTYLAGCGLQSCAMLVAKGYPDMGWNPIEGERYLSFLRFAVFCNGESVEENANVVV KLLIRRPECFGPALRGEGGQGLLAAMKEAIKISKDPALDLPKPSAAITTGCGEEEEEIIH MGNAIMSFYSALIDLLGRCAPEMHLINAGKGEALRIRAILRSLVPTTDLVGVISIPLTKP TVNKDGEVTEPDMSACFCPDHKAPMVLFLDRVYGIEDQSFLLQLLEVGFLPDLQAAASLD TEVLSITEMALAMNRYINSAVLPLLTRCATLFASTEHYAHLIDATLQTIYRLSKGRSLTK AQRDVIQECLLTICKHLRPSMMQQLLRRLVFDVPLLTEYCNIPLRLLTNHYEQNWKYYCL PCGMNTFGTASEEELLLTKKLFWGIFDSLTQKKYDAELFKMANCCLCAIAGALPPDFVDA SLGAMLENQASIDAQGNFDPKPINTANISLPEKLEFFANKYAEHSHDKWSSEKVSAGWKH GDGLDEHAKKHPLLKPYTSLSEKEKETYRWPVRESLKSMLAMDWNIERTKEGEAMFQQRE NEKQRKISETQVNGFTPAPLDLHNFTLSRELQSMVEVIAENYHNIWAKKKKSELMSKGGG SHPLLVPYDTLTAKEKYRDREKAQELFKFLQISGYAITRGLKDMEQDSSSMEKRFAYKFL KRLIKCVDSAQEFIAHLEAMATSRKTDKSPHDQEIKFFAKVLIPLTDQTFKSHCLYFLST ASKNLSSCGYASNKEKEMVTSLFCKLAALVRHRISLFGSDSTMMVSCLHILTHSLDTRTV MKSGSEVVKAGFRTFFENAAEDLEKLVEMLKLGKFMQSRAQMKSVSQSIHYVTVALLPIL TALFDHVKTHDFGVDLLLDDVQLSCYRILTCYYSLGTGKNIFVERYLPALGESLATLVGA MPVAFLEPHLNPHNPLSVFNTKTPRERAILSMPDTVEEMCPEMPRLDKLLKDVNDVSETG ARYNEMPEVIEVILPMLCNYLSYWWGKGPENPPLSGECCTTVTSEHLSIILGNILKILNN NLGIDDAPWMKRIAVYSQPIISKAGAGLLRTHFLPTLEKLKKKTVKVASEEELLKADGKS DNQEAELLILDEFAVLCRDLYAFYPMLIRYVDINRSRWLKEPHTDSTELFRMVADIFILW CKSHNFKREEQNFVVQNEINNLGFLTGEGKTKMSKSGGDQERKHKRRRGDYYSIHTSLIV AALKKMLPIGLNMCTPGDQELISLAKMRYSQKDTDEEVKDHLRQNLHLQDKSDDPAVQWQ LNLYKDIAMKSDEPVNPEHTVDRVQSISAAVYYLEQVEQPLRNKKCVWQKLLSKQRKRAV VACFRMAPLYNLPRHRAINLFIPAYQRIWIEAEEYSFEEKLVQDLAKTPMKIVEEDEEEV AEVQPDPLHQLILLFSHNALTERSHLEEDPLYIAYADMMAKSCAEDEEEEDEEEKEKTFE EKEMEKQKTLYQQARLHARGAAEMVLQMISASKGHLGPMVTCTLKLGISILNGGNVQVQQ KMLDYLKEKRDASFFKSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSIHTERGSKVL LNDEFTKDLFRFLQLLCEGHNGEFQNFLRTQTGNTTTVNIIISTVDYLLRLQESISDFYW YYSGKDIIDETGKVNFSKALSVAKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHV FANMQMKLSQDASQIELLKDLMDLQKDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSNNV EMILKFFDMFLKLKHLTMSENFKEYDPEFKGVISKKEFQKSMESQKQYSQSEIDFLLSCA EADENDMFNYKEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDSRLAAFLDLAESVLSYFE PYLGRIEINGSAKRIERVYFEISESSREQWEKPQVKESKRQFIFDVVNEGGESEKMEMFV NFCEDTIFEMQLASQISEPDAVEQLEGEEEEVLTILDELAGEEGSSESASAFTLACQSVK KRFRHLRQIVTVKSLRKKLRKFRKLSIKEMITCFFSFFWVVFTGFFKGISNLIFGFFHVI WSSMFGGGLVEGAKNMKVTDILGNMPDPTQFGIHGDTIEGEKFEAMESSGSSDPTMVPAA DIAEVDTMLDILSMPKREGGKLVEHGLGDVSDLNGESSTTDHKKPAAKADESPESEPEKA DTENQEKEDQPKKEEAKEPLLEEKPKAKSSRAKEASPAFMSNVFSALDVYLTKLLNYLAR NFYNLRFLALFVCFAINFILLFYKVTAEEEGDDDNHWEEHDEDTLFDMDEFVLQESTGYM LPTLRFLAVFHTVISLVCLVGYYCLKVPLVVFKREKEIARKLEFDGLYITEQPSDEDIKG QWDRLVINSPSFPSNYWDKFIKRKVINKYGDLYGAERIAELLGLDKSALDFDPTAETVEK EASLLSWLSSIDTKYHIWKLGVVLTDNSFLYLIWYTTMSIFGHFNNFFFAAHLLDIAMGF KTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRRFYNKSEDEDEPDMKCDDMM TCYLFHMYVGVRAGGGIGDELEDPAGDPYELYRILFDITFFFFVIVILLAIIQGLIIDAF GELRDQQEQVKEDMETKCFICGIGNDYFDRTPHGFETHTLQEHNLANYLFFLMYLINKDE TEHTGQESYVWTMYQERCWDFFPTGDCFRKQYEDQLG NT seq 14514 nt NT seq  +upstreamnt  +downstreamnt atggccgagggcggggatggggaggacgagatccagttcttgagaactgatgatgaggtg gtccttcagagcgtggccaccattcaaaaggagcatcgcaagttttgcctggccgccgag ggacttgggaaccgcttatgttacctcgaacccacctctgaagccaagtatgttcctccg gacttgtgcatttgtaactttgtgctggagcagtcgctgtcggtgcgagccctgcaggag atgctggctaacacgggacagagcagcgaaggggcgggtcaggggggcggacatcggacc ctgctctatggtcacgccatcctcctgcgccactccttcagtggcatgtacctgacctgc ttgaagacatcaaggtctctgacagacaagttgtcattcgatgtgggactacaacaagat gcaataggagaggcctgttggtggaccatccaccctgcctccaagcagaggtctgaggga gagaaagtccgcatcggagatgacctgatcctcgtcagcgtgtcaacggaacgctacttg cacctctccatctcgaatagcaacattcaagtggacgcgtccttcatgcaaaccctgtgg aacgtccaaccaacctgttcctcaagcaacatggctgtcgggtatttggttggtggtcat gtgatgcgtctctgtcgtggccatgatgagagcttgaccatccctggagcagaaaggagt gaggaggagcagaggatagtcaactacgaagcagggaagggagcgtcaaaagcacgctcc ctatggatactggagcctttgaggatcagctggagcggaagccacattcgctggggacag ggcttccgactacgccatctctccaccggccattacctggcactgactgaggaccgggga ctggtcctgcaggacagggagaggtccgacaccacggccacctccttttgcttcaggccc tccaaggaaaaaagcgagtcgggcccaaagagagacattgacggcatgggtgtgccagag atcaaatatggcgattctgtctgcttcatcatgcacgtggcaactggactgtggctgtcc tatcaagcgcctgatgccaaatcatctcgtcttggacccatgaaaagaagggcctgtctg cattctgagggccacatggatgacggcttgactctccagcgctgtcagcatgaagagtct caagcggctcgcaacatccgtaatacaacgttcctcttcaccaactttatcaaggccttg gacagcaccgccacaggcgtgtccatggaggtggccggctacgtccaggaggtgctacag atgctgaatgacctgatcgagtacttcaagcagcctgactcggagctggaacatgaagag aagcaatgtctcctgcgatcgctcatcaaacgtcaagacctcttcaaagaggagggcatg ctggccctcctgtcaaaatgcatcgaccggatgaacctgtacaatagcgccgcccacttt ggggagatggctggggaagaggccggggcagcgtggaaggacatcctcaacctcctctac gagctccttgctgcacttattcgtgggaacagaaacaactgcacccagttttctcgcaac ttggactggttggtcagcaaactggaaaggctcgagtcatcatcaggcatcctggaagtt ctacactgtgtcttgattgaaagtccggaggctttgaacatcatccagagaggacacatc aaatctatcatctctttgctgtgcaaacatggacgcaaccacaagattctagacgtcttg tgctccctttgtgtatgtaatggcgtggctgtgagagccaatcaaaatctgatatgtgac aacctgcttcccaaaagggacctgcttcttcagacccgactagtcaacgatgttcatagc atgaggccaaacatctttttgggtgtggctgaaggctctgcccaatacaaaaagtggtat ttcgagctggtggtcgatcaggtggaccactttgtaacggctgaatcgactcacctgagg gtaggctgggctaacacaaaaggctatgccccgtatcctggtggaggcgagggctgggga ggcaacggcgttggcgacgatctctactcttacagctttgatggtcttcacctgtggtca ggtcgcatcccgcgggcggtggcctctattaaccagcacctactaacttcagacgacgtg gttagctgctgtctggatttgggctcccccagcatgtccttccggatcaacggtcaaccc gttcagggaatgtttgaagacttcaacacagatggattcttcttccccgtcatcagcttc tctgccggtgtcaaggtgcgtttcttgttgggtggacgacatggagattttaagttcctg cccccctctggttactctccgtgctatgaggcactgctgccaaaggagaagatgtacgtg gagcctgtgaaagagcacaagagggatcacgatggggtccaagacctgttgggaacgacc cagtttctctcccaggcctccttcattcccactccggttgacaccagccagattgttctt ccgcctcacatggacaacatccgggacaagctggcagaaaacattcacgaactgtggggg atgaataagatcgagctaggatggacgtatggcaagattcgggatgacaacaagaggcag cacccatgccttgttgattttgccaagctgcctgaaacagaacggaactacaatctgcaa atgtccagtgaaacacttaagaccctcgtggctcttggatgtcatgttgcccaggtcaat attcatgctgaggacgatctgaagaaaatcaaacttcccaaagattacatgatgtccaac ggatataaacctgctcctctggacctttccgacgtgaagctgactgcacgtcaggaggtt cttgttgaaaagctagcagagaatgcacacaatgtatgggccaaagacagaattaaacag gggtggacctatggaatccagcaggatttaaagaacaggcgtaatcctcgcctggtgcca tatgctttactcgacgagcgcacgaagaagtcgaatagagacagtctaagggaggccgtc aggacgatggttggctatggatatgacatcgaccctccagaccaggagactgtccacgtg acggacaatcagaggattgagactctgcgattcttccgggtggagcaaacgtacgcggtg aaaaggggaaagtggtactttgagtttgaggccctgagcggaggcgatatgagggttggc tgggcgaggccaggctgcagacctgatgtggaactgggaacagatgaccaggccttcgtc tttgatggatacagggctcggcgcttacatgccgggagccgctactttgggcacctgtgg aaaagaggagacgtagtcggctgcatgatcaacatgcaggataaatcgattattttcacc ctgaacggcgagcttctgatcaccaacaaaggctcagagctttgcttcactgactttgag gcagaagatggttttatcccagtgtgtagtgtgggcatgtctcaggttggacgcatgaac cttgggaaggatgccagcaccttcaaatactacaccatgtgcggccttcaggaaggcttt gagcccttcgcggtcaacatgaacagagaaatcaccatgtggtttagcaaacgcctggca acttttgtcaacgtaccgcagggtcacagggatatcgaggtgacgaggattgacgggaca gtggacagcccaccctgcctaaaggtcacccacaagacttttggcacccagaacagcaac aatgaaatgatctactgccgactgagcatgcccgtggagttcttccctgcagacatgtta cttgacgaatcgtttccactaagtcatcctccaaaatcagatggggcgacagactacggg aggatcacaacttactaccactccgtgcgagtgtttgccgggcaggaccccgcgtctgtg tgggtgggctgggtgacgccggactatcattactattcaaagaacttcagcctcaccaac acgagaacagtcactgttaccttgggagacgagaggggtcgggtccatgagagtgtccag agaagtaactgctatatggtttgcggagcggaggcaatcggcccttcttcatccagccgc tccaactctgacgtggagattggctgcctgttggacctggctactggccttgtttccttc actgcaaacggcaaggagctgtctaccacttatcaggtggagccaagtaccaagctgttt cctgctgtgtttgtacggcccacctgtgtaaacctttttcaatttgaatttgtcaagatt aaggacgccatgccaatctcctcggctatatttaaaagtgagcacaggaacccggtgcct caatgccctccacgactgaacgtgcagaccatcgtggcagtgctctggagccgcatgcca aacactttcctcagcgtggagactgctcgagtcagcgagagacacggatgggttgtccag tgcttggaaccgctgcagatgatggctgtacatatacccgaggaaaatagatgtttggac atcttggagttatcagaacacgaagacttaaggaagttccattatcacactctcaagctg tactgtgccctctgtgccctcggtaacactcgtgtagcgcatgccctctgcagccacttg gaccagtcgcagctcctctacaccatcgacaatcagtatctctctggcatgctaagggaa ggcttctacaatgtcctcatcagcatccatcttgaaacggcgaaagaggctcgcctcatg atgaacaatgagttcatcatccccgtgacggacgagacgcgctccatcaagctgttcccc gatgaaagcaaaaagcactctctccctggcgtaagcctgagcacatccctgaagcctcgg gtcaacttctcccccgcctgtatcatcagcatcaagcgccagcagtatctccacagtccc cagatccccttgggcatcctaaaagagaaggccatcaacatgcttagtgaggccgtgcag ggtggcggcatccatatcagagaccctgtgggcgggagtgtggagtaccaatttgtgccc atcctcaagctgatcggaacactgttgatcatgggagtcttgaacagcgaggaagtgagg ctgattctcctcctgatcgatcccaatgtgtttggggaggtcgaggaggccaaggtggag gaaggggctgttacccggaagacagaagaggtgagcacgagtgcagaaaagtccaccgag gcgggagaagaggagacgaaggagaataaggcctcagtccgcggtcttctggagaagtct ttgccggagtctgtcaaacggcagatgtgtgaactgctgcattacttctgtgactgcgag ctgaagcaacgtatcgaagccattgtctccttctcggacaactttgtgtccaagctgcag cacaaccagaaattccgctacaatgagctgatgctggcgctcaacctgtccgctgccatc acggccaagaagaccaaagagttccgctcacctccccaagaacagatcaacatcctgttg aacttcaccgcaggcgacgactgcccctgtcctgaagacctgcaggaggaactcaaggcc ttccacgaagaactgcaactgcactgcggaatcccagttgaggaagatgaggacgagcag gacacatcgattaaaggccgactcctggccttgctgtacaaaatcaaaggtccgccacaa aagatggaggaggaacctgaagagaaagagcaggcttcccctaccaatctaaaggagctg atctcccaaactataaccacctgggcccaggagacgcacatgcaggatcctgagctggtc cgagtgatgttcagcctgctcaggaggcagttcgacggcatcggggaactgcttcgggcc atgaagaagtcttacaccatcagtgccgcttctgtgcaggatgctatcaacctgctggcc tcactgggtcaaatcaggtctctgctgtctgtccgcatgggcattgaggaggaaaagctc atgattgatggactggggaacattatgaacaataaggttttctaccagcatccaaacctc atgagagtgctgggcatgcacgagactgtcatgcaggtcatggtcaatgtgctaggagga gacaagtctcaggaaattgccttccccaagatggttgcgagctgctgtcgctttttgtgc tatttctgtcgtattagccgccagaaccagaaagccatgtttgaccacctcagctacctg ctggagaacagcagtgttggtttggcttctgaagcgatgcggggctccacgccgctggat gttgctgcatcatcagtgatggacaacaacggcctcgctctggccctggaggaaccggat ctagaaaaggtggtgacataccttgcaggatgtggtcttcagagctgtgccatgctggtt gccaagggttacccagacatgggatggaaccccatagaaggggagcgttacctgtccttc cttcggtttgcagtcttctgcaatggtgagagtgtcgaggaaaacgccaacgtggtggtg aagctgctgatccgacgtcccgagtgttttggcccagctctgagaggagaagggggccag ggtctgctggcggccatgaaagaggccatcaagatatctaaggatcctgctctcgaccta cccaaaccctcagctgccatcacgactggatgtggtgaggaagaagaggaaataatccac atgggcaacgctatcatgtccttctactctgccctcattgacctgcttggtcgctgcgct ccagagatgcatcttatcaacgcaggtaaaggtgaagcgctgcgtattcgagctattctc cgctcgctggtccccaccactgatttggttggcgtcatcagcatacccctcacaaagccc acggttaataaagatggcgaagtgacagaacctgatatgtcagcctgtttctgtccggat cacaaggcccccatggtgctcttcctggacagggtgtacggcatcgaggaccaaagcttc ctcctccagctgttggaggtcggcttcctacctgacctccaagctgctgcctctcttgac acggaggtgctgagtattacggagatggcgctggcaatgaacaggtacatcaactcagct gtgctgcctctgctgacccgctgtgccaccttgtttgccagcacggagcactacgcgcat ctgatcgatgccacgctgcaaaccatctaccgcctctccaaaggacgctcgctcaccaaa gcacagagagatgttattcaggagtgcctgctgactatctgcaagcatctgcgtccctcc atgatgcagcagctgctcaggcgcttggtgtttgatgttcccctgctcacggaatactgc aacatacctctaaggctactgaccaaccactatgaacagaactggaagtactattgtttg ccatgtgggatgaacacctttggcacagcctcagaggaggagctccttctcacgaagaaa ctcttctggggaatttttgactcgctcactcaaaagaaatatgatgctgaactgttcaaa atggccaactgctgcctttgtgccattgctggagccctgccgcctgacttcgtggatgcc agtttaggagcaatgctggagaaccaagcatccatcgacgcacagggaaactttgacccc aaacccataaacactgccaatatctccctacctgaaaaacttgagttttttgccaacaaa tatgcagagcattcccatgacaagtggtcttcagagaaggtgtccgcagggtggaaacac ggagacggcttggatgagcacgccaaaaagcatccactgctaaagccttacacatctctc agtgagaaggagaaagaaacgtaccgatggccggtgagggagtcgttgaagagcatgctg gccatggattggaacattgagaggaccaaggaaggagaagccatgttccaacaacgggaa aatgagaagcagcgaaagatctcagagacacaggtcaatggattcactcctgctccattg gacctgcacaatttcacgttgtcgagagagctgcagagcatggttgaggtgattgcagaa aattatcacaacatctgggccaagaaaaagaagagtgaactcatgagtaaaggaggaggg agccacccgctgctggtaccctatgataccctgacggctaaagaaaagtaccgagacaga gagaaggcccaggagctcttcaagttcctgcagataagcggctacgccatcacaagaggt ctgaaagatatggagcaagactcttcatccatggagaagcgttttgcctacaagtttctc aagaggctcatcaaatgtgtcgactctgcccaggagtttatcgcacaccttgaggcgatg gccacgagcaggaagactgacaaatcaccccatgaccaggaaatcaaattctttgctaag gtgttgattccgctaacggatcagacttttaagagccactgcctctacttcctgtccacg gccagcaagaacctcagcagctgtgggtatgcctccaacaaagaaaaagagatggtcacg agccttttctgtaaactggcagctcttgtcagacacaggatttctctctttggaagtgac tctacaatgatggtgagctgccttcacattctcactcactcacttgataccagaactgtg atgaaatcgggttcggaggtggtcaaagccgggtttcgaaccttctttgagaatgcagcg gaagacctggagaagcttgtggagatgctcaaactggggaagttcatgcagtcgcgtgcc cagatgaagagcgtcagtcagagcattcactacgtgactgtggcgcttctgccgatcctc accgccttattcgatcacgtcaaaacgcatgattttggagtggatctactgttggatgac gttcagctctcctgctaccgaatccttacttgttactactctctgggaacaggaaagaac atctttgtggaaaggtacctgccagcacttggtgagagcctggccactctcgtgggtgcc atgcctgtagctttcctggaacctcatctgaacccccacaacccactctccgtcttcaac accaagacaccacgcgaaagggccatcctaagtatgcctgatacggtggaggaaatgtgt ccagagatgcctcgtcttgacaagctgctcaaggatgtcaacgatgtctcagagactggt gcacgctacaatgagatgccagaggtgattgaagtgatcctgcccatgctgtgcaactac ctgtcctactggtggggaaaaggtccagaaaacccacctttgagtggcgagtgctgcacc acagtgacatcggagcacctcagcatcattctcgggaacattctcaagatcctcaacaac aacctgggcattgacgacgccccctggatgaagaggattgcagtctactctcagccgatc atcagcaaagcaggagccggtttgttgagaacccactttttaccaacgcttgagaaactg aagaagaaaacggtgaaggttgcgtccgaggaagagttattgaaggctgatggcaaaagt gacaatcaggaggcagagcttctcatcttggacgaatttgctgtgctctgccgagacctc tatgccttctaccccatgctcattcgctacgtcgacatcaacaggtcaaggtggcttaag gagccccatacagactccactgaactctttcggatggtggcggatatcttcatcctctgg tgcaagtcgcacaattttaagcgcgaggagcaaaactttgtcgtccagaacgagatcaat aatttaggcttcctcactggagaaggcaagacgaaaatgtccaagtccggtggcgaccag gagaggaagcacaagcgtcgtcggggggattactactccatccacacctctttgattgtg gccgcactgaagaagatgctgcccatcggcctcaacatgtgcaccccaggggaccaggag ctcatctccttggctaaaatgcgttacagtcagaaagacactgatgaagaggtgaaggac cacttgcgacagaaccttcatctgcaggacaagtctgacgacccagcggtccagtggcag ttgaacctctacaaagacatcgcgatgaagagtgacgagccagttaacccggaacacacg gtggatcgggttcagagcatctcagctgctgtttactatctggaacaggtggagcagcct ttaaggaataaaaagtgcgtgtggcagaagctgctgtccaaacagcgtaaacgggctgta gtggcctgcttccgaatggcccccctttataatttaccaaggcatcgtgctatcaacctc ttcatcccggcctatcaaagaatatggatagaggcagaggagtactcctttgaggaaaag ctagttcaggatctggcaaaaactcccatgaaaatagtggaggaggatgaagaagaggtg gctgaagtgcagccagaccctctgcaccaactcatcctcctttttagccacaacgctctg acagaaagaagtcacttagaagaagatcctttgtatatcgcatatgctgacatgatggca aagagctgtgcagaggatgaggaagaagaggatgaagaagagaaagagaaaacgtttgag gaaaaggagatggaaaagcagaaaactctgtatcagcaggcgaggcttcatgctcgcggg gcagctgagatggtgttgcagatgattagcgctagcaaaggacacctgggccccatggtg acttgcaccctcaaactcggcatttccatcttaaacggaggcaatgtgcaagttcagcaa aaaatgctggattacttgaaagagaaaagagatgcgagctttttcaaaagcctctcagga ctgatgcagtcgtgcagtgtcctcgacctgaatgcatttgagaggcagaataaggcagaa ggactcggcatggtgacagaagaaggttcaatccacactgagcggggttctaaggtgtta ctgaatgacgagtttacaaaagatctgttccgctttttgcaacttctgtgtgaggggcac aatggggagttccagaacttcctgagaactcaaactggaaacacaaccacagtcaacatt attatcagcactgttgactatttgctccgccttcaggaatcgatcagtgacttctactgg tactactctggcaaagacatcattgatgagacaggcaaagttaacttctccaaagcgtta tctgttgccaagcagatattcaactccctgactgaatatattcagggtccttgtatcgga aaccagcagagcctcgctcacagcagactgtgggatgcagtcgtgggcttcttgcatgtt tttgccaacatgcaaatgaaactgtctcaggatgccagtcagattgagctgctgaaggat cttatggatttgcagaaggacatggttgtcatgctgctgtctctgctagaaggcaacgtt gtgaatggaacaatcgggaagcagatggttgacactcttgtggagtcttcaaacaacgtt gagatgatcctgaaattctttgacatgttcctcaagctgaagcacctgacgatgtcagaa aatttcaaggagtacgaccccgagttcaaaggcgtcatctccaagaaagagttccagaag tcaatggagagccaaaagcaatacagccaatcggagatcgacttcctcctctcctgcgcg gaggccgacgagaacgacatgttcaactacaaggagtttgtggagcgattccatgagccg gccaaagacatcggcttcaacgtagccgtgctactgaccaacctgtccgagcacatgccg catgacagccgcctcgccgccttcttggatctggctgagagtgtgctgagctacttcgag ccttacctggggcgtatcgaaatcaacggcagtgcaaaacgcatcgagagggtatatttc gagatcagcgaatccagccgggagcagtgggagaagccgcaagtcaaagagtccaaacgc caattcatctttgacgtggttaacgagggaggcgagagcgagaagatggagatgtttgtc aatttctgcgaggacaccatttttgagatgcaactggcctcacaaatctccgaaccagat gcagtggaacagctggagggggaggaagaggaggtcttgaccatcctggatgaactggct ggggaagaggggtcctcagagtctgcctctgctttcactttggcctgccaatcagtcaag aagcggttccgccacctacgccaaattgtcaccgttaaaagcctccgcaagaagctcagg aaattcagaaagctaagcattaaggagatgatcacgtgcttcttctccttcttctgggtg gtcttcactggcttctttaaaggaatcagtaacctgatatttggtttcttccacgtgatc tggtcttccatgtttggcggcggcttggttgaaggtgccaagaacatgaaagtgacagac atcctgggaaatatgcctgatcccactcagttcggcatccacggagataccattgaagga gaaaaatttgaggcaatggagtcttcaggcagttctgatccaactatggttccagcggca gacatagctgaggtggacactatgttggacattctgagcatgcccaagagggaaggcgga aagctcgtggagcacggactgggggacgtctctgacctcaatggcgagagctccaccaca gaccacaagaaacccgccgccaaggcggatgaatcccccgagagcgaaccggagaaagca gacacagagaaccaagaaaaggaggaccaaccgaagaaagaggaagccaaggagccactg ttggaggagaagcccaaagcaaaatcaagtcgagccaaagaagcttctcctgccttcatg tcaaatgtcttctctgcgcttgatgtctatttgaccaaactgctgaattatctagctcgc aacttctacaatctgcgcttcctagctctgtttgtgtgtttcgccatcaacttcattctg ctcttctacaaggtcactgccgaggaagagggagatgatgacaaccactgggaggagcat gacgaggacacgctctttgacatggatgagtttgttctccaagaaagcaccggctacatg ttgccaaccctgcgcttcctggccgtattccacacagtcatctccctcgtgtgcttggtg ggatactattgtctgaaggttcctttggtggtgttcaaacgagagaaggagatagccagg aagctggagtttgatggcctttacatcaccgagcaaccatctgatgaagacattaagggc cagtgggatcggctagttatcaactctccgtcttttcccagtaactactgggacaagttc atcaagcgcaaggtgatcaacaaatatggggacttatatggagcagagcgcatcgccgaa ctcttaggcctggataagagtgccctggactttgaccccacggcggagactgtagagaag gaagcttcactgctctcctggctcagctccattgacaccaaataccacatttggaaattg ggagtggttctgactgataattctttcctgtatctaatctggtacaccaccatgtccatt tttggacacttcaataacttcttctttgctgcccacctgctggacattgccatgggcttc aagactctccgtaccatcctgtcttcagtcacacataacggcaagcaactggtgctgaca gtgggtctgctggcagtggttgtatatctctacactgtggtggccttcaactttttccga aggttctacaataagagtgaggacgaagatgagcctgacatgaagtgtgacgacatgatg acgtgctatctgttccacatgtacgtgggtgtaagagctgggggtggtatcggagatgag ttggaggacccagctggggacccctacgagctctaccgcatcctttttgacatcaccttc ttcttctttgtcatcgtcatcttgctggccatcattcagggtttgatcattgatgccttt ggtgagctgagagaccaacaggagcaagtgaaggaggacatggagaccaaatgcttcatc tgtggcatcgggaacgactactttgatcgcacgcctcacggttttgaaactcacacttta caagagcacaaccttgcaaactacctgttcttcctgatgtacctgattaacaaggatgag acggaacacacaggccaggagtcgtatgtgtggacgatgtaccaggaaagatgctgggac ttcttcccaaccggagactgtttccggaagcaatacgaggaccagttgggctaa

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