Heterocephalus glaber (naked mole-rat): 101707544 Help Entry 101707544         CDS       T02812                                  Symbol Ryr3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism hgl  Heterocephalus glaber (naked mole-rat) Pathway hgl04020   Calcium signaling pathway hgl04371   Apelin signaling pathway hgl04713   Circadian entrainment hgl04921   Oxytocin signaling pathway hgl04970   Salivary secretion hgl05010   Alzheimer disease hgl05012   Parkinson disease hgl05020   Prion disease hgl05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:hgl00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     101707544 (Ryr3)    04020 Calcium signaling pathway     101707544 (Ryr3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     101707544 (Ryr3)   09154 Digestive system    04970 Salivary secretion     101707544 (Ryr3)   09159 Environmental adaptation    04713 Circadian entrainment     101707544 (Ryr3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     101707544 (Ryr3)    05012 Parkinson disease     101707544 (Ryr3)    05020 Prion disease     101707544 (Ryr3)    05022 Pathways of neurodegeneration - multiple diseases     101707544 (Ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:hgl04040]     101707544 (Ryr3) Ion channels [BR:hgl04040]  Voltage-gated cation channels   Ryanodine receptor    101707544 (Ryr3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  101707544 NCBI-ProteinID:  XP_012933814 LinkDB All DBs Position Un AA seq 4859 aa AA seqDB search MSEHKSDEDEVVLQCIANVHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIPPDLCICNFVL EQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAVLLRHSFSGMYLTCLTTSRSQT DKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYLHLSISNGN IQVDASFIQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTDQNDPQHRRIF YEAGGAGRRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTEDQGLLLQDRGK SDTKSTAFSFRASKEIKEKLDSSHKREMEGMGIPEIKYGDSVCFVQHVASGLWVTYKAQD AKTSRLGPLKRKVILHQEGHMDDGLTLQRCQLEESQAARIIRNTTALFSRFVSGNSRTAA PITLPIEEVLQTLQDLIAYFQPPEEEMKHEDKQNKLRSLKNRQNLFKEEGMLALVLNCID RLNIYNSVAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSNNLDWLISKLD RLESSSGILEVLHCILIESPEALNLIAESHIKSIISLLDKHGRNHKVLDVLCSLCLCNGV AVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKWYFELIIDQVD PFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLWSGRIPRSVAS INQHLLKSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVMSFSAGVKVRFL MGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDADGVRDLLGTTHLLSQASFI PCPVDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKRQHPCLVEFSK LPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEELKKVKLPKNYMMTNGYKPAPLDL SDVKLFPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLVPYTLLDERTK KSNRDSLREAIRTFLGYGYNIESSDQELADPAVEKISIDKIRCFRVERSYAVRSGKWYFE FEAVTGGDMRVGWARPGCRPDMELGADDQAFVFEGSRGQRWHQGSGYFGRTWQPGDVVGC MINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICSLGLSQIGRMNLGMDASTF QFYTMCGLQEGFEPFAVNMNRDVAVWFSKRLPTFVNVPKDHPHIEVVRIDGTMDSPPCLK VTHKTFGTQNSNANMIYCRLSMPVECYSSFTHSPCLDTDAFQKRKQMQEILSPTTTQCYY AIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLHKNCTVTVTLGDERGRVHESVKRSNCYMV WGGDIVASSQRSSRSNVELEIGCLVDLAMGMLSFSANGKELGTCYQVEPNTKVFPAVFLQ PTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDVQTIQPVLWSRMPNSFLKV ETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMRFHYHTLRLYSAVCA LGNSRVAYALCSHVDLSQLFYTIDNKYLPGLLRSGFYDLLISIHLANAKERKLMMKNEYI IPITGTTRNIRLYPDESKRHGLPGVGLRTCLKPGFKFSTPCFVVTVEEHQKQSPEIPLEI LKTKALSMLKEAVHCSGAHIRDPVGGSVEFQFVPVLKLIGTLLIMGVFDDDDVRQILLLI DPSVFGEHSGETEERAEKEEVNQVEEKAVEAGEKASKEAPVKGLLQTRLPESVKLQMCEL LSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTARKTKEFRSPP QEQINMLLNFQLGENCPCPEEIREELYDFHEDLLIHCGVPLEEQEEEEEDTSWTGKLRAL VHKIKGPPKPEKEQPAEEEERCPATLKELVSQTMIRWAQEDQIQDAELVRMMFSLLRRQY DSIGELLQALRKTYTISQASVSDTINLLAALGQIRSLLSVRMGKEEELLMINGLGDIMNN KVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVASCCRFLCYFCRISRQNQKA MFEHLSYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALGLEEPDLEKVVTYLAGCG LQSCSMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKLLIRRPECFGP ALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKRAVTEDHEEEEEIVHMGNAIMSFYSA LIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPSLNKDGSVNEP DMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDTVSLSTTEAAL ALNRYICSAVLPLLTRCAPLFAGTEHCTSLIDSTLQTIYRLSKGRALTKAQRDTIEECLL AICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCLPSGWGSYGLAM EEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDTRITATLEKQVS VDADGNFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQSGWRYGISLDENMKTH PLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQRENEKLRSVSQTG QGNSYSPAPLDLSNVALSRELQGMVEVVAENYHNIWAKKKKLELESKGGGSHPLLVPYDT LTAKEKFRDREKAQDLFKFLQVNGIIVSRGMKGMEMDTSSMEKRFAYKFLKKILKYVDSA QEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHHLYFLSSPLKPLSSSGY ASHKEKEMVASLFCKLAALVRHRISLFGSDSATMVSCLHILAQTLDTRTVMKSGSELVKA GLRGFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTAALLPILTSIFEHVAQH QFGVDLLLNDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAAIPVAFLEPTL NRYNPLSVFNTKTPRERSILGMPDTVEEMCPDLPQLDGLMKEINELAESGARYTEMPHVI EVILPMLCNYLSYWWERGPENLPPSTGPCCTKVTSEHLSLILGNILKIINNNLGIDEASW MKRIAVFAQPIISKARPDLLRTHFIPTLEKLKKKAVKTVQEEEQLKADGKGDTQEAELLI LDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDDDSDQLFRMVAEVFILWCKSHNFKRE EQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGDLYSIQTSLIVAAL KKMLPIGLNMCTPGDQELISLAKSRYSCRDTDEEVKEHLRNNLHLQEKSDDPAVKWQLNL YKDVLRSEEPATPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWYKLLSKQRKRAVVACF RMAPLYNLPRHRSINLFLHGYQRFWIETEAHSFEEKLVQDLAKSPKAEEEEEEETENQPD PLHQIILHFSRNALTERSKLEDDPLYTSYSSMMAKSCQSDEDEEEEDKEKTFEEKEMEKQ KTLYQQARLHERGAAEMVLQMLSASKGEMSPMVVETLKLGIAVLNGGNTGVQQKMLDYLK EKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERGEKVLQNDEFT RDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNIIISTVDYLLRLQESISDFYWYYSGKD IIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQM KLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNVEMILKF FDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDFLLSCAEADEND MFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESVLNYFEPYLGRI EIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELFVNFCEDT IFEMQLASQISESDSADRPEEEEKESEESSYVLEMEGEEEEDKSFEPASAFAMACASAKR NVSNLLKKATLKNLRKQYRNVKKMTAKELVKVFFSFYWMFFVGLFQMFFTILGGIFQILW NTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDAMEAERAEVVEPGLTAELVHCMKGE KGDTDIMSDLFGLHPKKEGGLKHGHEVGLGDLSEIIGKDEPPTLENTVQKKRKAQAAEMK AAHEVEGKVESEKADMEGREKEDKAKEEEQAKYLWAEVTKKKKRWRSQKAEKPEAFMANF FKGLDIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEEETEDVANLWNS FNDEEEEEAMVFFVLQESTGYMAPTLRALAVVHTIISLVCVMGYYCLKVPLAVFKREKEI ARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGDLYGAERI AELLGLDKNALDFSPVEETKAEAASLVSWLSSVDMKYHIWKLGVVFTDNSFLYLAWYTTM SILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNF FRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMYRIVFDI TFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTPHGFETH TLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14580 nt NT seq  +upstreamnt  +downstreamnt atgtctgaacacaaaagtgatgaagatgaagtggtcctgcagtgcattgccaatgttcac aaggagcaaaggaagttctgcctggcagccgagggacttgggaatcgcctgtgcttcttg gaacccacctcagaagcaaagtatattcctccagatctctgcatctgcaattttgtgctg gaacagtctctctctgtcagagcgctgcaggaaatgcttgccaacacgggtgaaaatggt ggcgaaggggcagcacaagggggtggccacaggaccttgctatatggccatgcagttctc ctgcggcactctttcagtggaatgtatctaacatgtttgaccacgtcaagatcccagaca gataaactggcctttgacgtaggtctccgggaacatgctacaggagaagcctgctggtgg accatacatcctgcttccaaacagaggtctgagggagagaaagtgcgaattggagatgac cttatcctcgtcagtgtgtcctctgaaagataccttcatctctcaatatccaatggtaat atccaagtggatgcctccttcatacaaactctctggaacgtacatcctacatgctcagga agtagcatcgaagaagggtatctactcggtgggcatgtggtgcgtctttttcatggtcac gatgagtgtttgacaataccatccacagaccagaatgatccccagcacaggagaatattc tatgaagctgggggagctgggaggagagccaggtccctgtggagagtggaacccctgcgg ataagctggagtgggagtaacatcagatggggccaggctttccgactccggcacctcacc acaggccactacctagctttgacagaggaccaaggccttctactgcaagatcggggaaag tcggacaccaagtccacagctttctctttccgggcatcaaaggaaatcaaggagaaattg gattctagtcacaagcgagaaatggaaggcatgggcattcctgaaatcaagtatggagat tctgtctgctttgttcagcatgtagccagtgggctctgggtcacctacaaagcacaagat gccaaaacatcccgcctgggacctctgaaaagaaaggtcattctccatcaggaaggccac atggacgatggattaacactgcagagatgccagcttgaggagtcccaggctgctcggatc atcaggaacacaacagccttattcagccggtttgtcagtggaaacagtcgcacagctgcc cccatcaccttgccaatagaagaggtcctgcagaccttacaggacttgatcgcctacttc cagcctccagaggaggagatgaagcatgaagacaagcagaacaagctccgctccctcaaa aacagacagaatcttttcaaggaagagggcatgttggctcttgtgttaaactgcattgat cgcttaaatatctacaatagtgtagcccactttgcagggattgccagagaagagagtggc atggcctggaaagaaattctgaacctcctgtacaagctgctggctgctctcattcgtgga aatagaaacaactgtgctcaattctccaataatcttgactggctgatcagtaaattggac agactagaatcttcctcaggtatcttagaggttttgcactgtatcttgattgaaagtcca gaagccttaaacctgatagcagaaagccacatcaagtctatcatctctctgttggacaaa catggacggaatcacaaggttctggatgtcctgtgctcactctgtctttgcaatggggtt gcagtaagagccaaccaaaacctgatctgtgacaacttactgccccggagaaatctgctc ctgcagacacggctaattaatgatgtgaccagtattcgaccaaacatcttcctgggagtt gctgaaggctcagcccagtacaagaaatggtactttgagctgattatcgaccaagtggac cccttcctaacagcagagcctacacacctgcgggtaggctgggcctcctcctcaggctac gccccttacccaggaggaggggaaggatggggaggcaacggtgttggtgatgacctgtac tcctatggctttgacggacttcatctctggtcagggcggatacccaggtctgtggcctcc atcaaccagcacctgctgaagtcggatgatgtggtgagctgctgtctggacctcggagtc cctagcatctctttccgcatcaatgggcagcctgtgcaagggatgtttgagaacttcaac accgatggcctcttcttccctgtgatgagcttttcagcaggtgtcaaagtacgtttcctc atgggtggacgtcatggagaatttaagttcctgcctccctcgggctatgccccttgctat gaagccttacttccaaaagagaagatgagactagagcctgtcaaagaatataaacgtgat gctgatggtgtgagagatctgctgggtaccacgcacttgctctcgcaagcctctttcatc ccatgccccgttgacaccagccaggttgttttaccacctcacctagagaagatccgagac agattggctgagaacatccatgagctttggggaatgaataaaatagagctcggctggact tttggcaaaatacgagatgataataaaagacaacacccctgccttgtggagttttcaaag ctccctgaaactgagaagaattataacctgcaaatgtcaactgaaaccttaaaaactctt ctggccctgggctgccacatcgctcatgttaacccagctgctgaggaggagctcaagaag gtcaaactgcccaaaaactacatgatgaccaatggctataagccagcccctttggatttg tctgatgtgaagctctttcctcctcaagaaattttagtggataagctggcagaaaatgca cacaatgtttgggcaaaagatagaataaaacaaggatggacctatggcattcaacaggat ttgaagaacaaaagaaatccccgtctggtgccgtatacattgctggatgagcgtaccaag aagtcaaacagggacagcctgcgtgaagccatccggacgtttcttggttatgggtataac attgagtcatcagatcaagaacttgctgatccagctgtagagaaaatcagtatagacaag attcgatgttttcgggtagagcggtcctatgcggtgagatctggaaagtggtattttgag tttgaagcagtgactggaggagacatgcgggttggctgggccaggccaggctgccggccg gacatggagctgggggctgatgaccaagcctttgtgtttgaaggcagcaggggccagcgt tggcatcaagggagtgggtattttgggagaacctggcagccaggagatgtggttggatgt atgattaacctggatgatgcctccatgatcttcacactgaatggggagctgctgatcacc aacaaaggctctgaacttgccttcgctgactatgagattgagaatggatttgtgcccatc tgctctctggggctgtctcagattggccgcatgaatctcgggatggatgccagtaccttc caattttatactatgtgtggcctccaagagggctttgagccttttgctgtcaacatgaac cgagacgttgcagtgtggttcagcaagcgcctcccgacatttgtcaacgtaccaaaggat catccacacatagaggtcgtgaggatcgatggcaccatggacagccctccatgcctcaag gtgacccacaagacatttggcacacagaatagcaatgccaacatgatctactgccgtctg agcatgcctgttgagtgctactcctccttcacccacagtccctgtctggacactgatgct ttccaaaaaaggaaacagatgcaagaaatactctctcctacaacaacacaatgctactat gccatccgaatcttcgcagggcaggacccctcctgcgtctgggttggatgggtgactccg gactatcacttgtacagtgaaaagtttgacctgcacaaaaactgtacagtgactgtcacc cttggggacgagagaggtcgggtccatgaaagtgtgaaacgcagcaactgctacatggta tggggcggagacattgtggccagttctcaaagatcaagtagaagcaatgtggaactggag atcggctgccttgtggatctggcaatgggcatgttgtccttctcagccaatgggaaagaa cttggcacctgctaccaggtggaacccaacaccaaagtgtttccagctgtcttcctgcag cctacaagcacttctctgtttcagtttgaacttggcaagctgaagaatgcaatgcccttg tctgcggccatatttaagagtgaagagaagaacccagtccctcagtgtcctcctcggctg gatgtccaaaccatccagccagtgctctggagccgcatgcccaacagcttcctgaaggtg gagacagagcgggtgagcgagcgccatggctgggtggtgcagtgcctggagcccctccaa atgatggcgctccacattccagaggagaacaggtgtgtggacatcctggagctctgtgag caggaagacctgatgcggttccactaccacacactgaggctgtacagtgccgtgtgtgcc ctaggaaacagccgggttgcctatgccctgtgcagccacgtggatctctcacagctcttc tacaccattgacaacaagtacctcccgggcctcctgcgctctggtttctatgacctgctc attagcatccacctggccaatgctaaggagcggaagctgatgatgaaaaatgagtacatt atcccgatcaccggcaccaccaggaatatccgcttatacccagatgagtccaagaggcat gggctgcctggggtgggtctgagaacgtgtctcaagccaggcttcaagttctctacccct tgcttcgttgtgaccgttgaggagcaccagaagcagagcccagagatccccttggagatt ctcaagacaaaggcactgagcatgctgaaggaggcagtgcactgtagtggggcccacatc cgagaccccgtgggggggtccgtggagttccagtttgtgcctgtgctgaagctcattgga accctgctgatcatgggtgtttttgatgatgatgatgttcgccaaatcctgctcctgatt gatccctctgtgtttggggagcacagtggggagacagaggagagagcagaaaaggaggaa gtaaaccaagtggaggaaaaggcagtggaagctggggaaaaggccagcaaggaggctcca gtcaaaggcttgttgcagacccggctacctgaatccgtcaagctgcagatgtgtgagctc cttagctatctctgtgactgtgagctgcagcaccgagtggaggccattgtggcatttggt gacatttatgtctccaagctgcaggcaaatcagaagttccgctacaatgagctcatgcag gccctgaacatgtctgcagccctgactgcccggaagaccaaggagttccgctcaccccca caggagcagatcaacatgcttctcaactttcaactgggagagaactgcccctgcccagag gagatccgggaggagctgtatgacttccacgaggaccttctcattcactgcggggttccc ttggaggaacaggaggaagaggaggaggacacctcttggacaggaaagctgcgtgccttg gtgcacaaaatcaaaggcccacccaagccagagaaggagcaaccagcagaggaagaggag agatgccctgcaacactgaaggaactagtgtcacagacaatgatccgctgggcccaggag gaccagatccaggatgcagagctggtccggatgatgttcagcctgctccggaggcagtat gacagcatcggggagctactgcaggcattgcggaagacgtacaccatcagccaggcctcc gtgagcgacaccatcaacctgctggctgccctgggccagatccggtcactcctcagtgtc aggatgggcaaggaagaggagctgcttatgatcaatgggctgggggacattatgaacaac aaggtgttttaccagcatcccaacctcatgagagtcctgggcatgcatgagacggtgatg gaggtgatggtgaatgtgctgggtacagagaaatcccagattgctttcccaaagatggtt gctagctgttgccgcttcctttgctatttctgtcgaattagccggcaaaatcagaaggcc atgtttgagcatctgagttacctgctagagaacagcagtgtgggcctagcctccccatca atgagagggtccaccccgttggatgtggctgccgcctctgtcatggacaacaacgagtta gcactgggcttagaagaacccgacctcgagaaggtggtgacttacttggcaggctgtggc ctacagagctgctccatgcttctggccaaagggtaccctgacgttggctggaatcccatc gaaggggagcgctacctgtctttcctgaggtttgccgtctttgtgaacagtgagagtgtg gaagaaaacgctagtgttgtggtcaagctgctcatcagacgcccagagtgcttcgggcca gccctgcggggcgaaggtggaaatggcctgttggcagccatgcaaggggccatcaagatc tctgagaacccagcactcgacctcccctcccagggatataagagagcagtcacagaggac catgaagaggaagaggagattgtgcatatgggcaatgcaattatgtcattttattcagct cttatagatctcctgggccgctgtgctcctgaaatgcatcttatccagacaggcaaaggg gaagccatccggatccggtccatcctgcgctccctggtccccacggaggacctggttggg atcattagcatccccctgaaactgccttccctgaataaagatgggtcagtcaatgagccc gatatggcggccaacttctgccctgaccacaaggcacccatggtgctgttcttggaccgt gtttatggcattaaggatcaaacttttctgctccatttgctggaggttggatttttacct gacttaagagcctctgcctctctagatacagtgtccctcagcaccacagaggctgcgctg gcgctcaacaggtacatatgctctgcggtgctcccactccttacgagatgtgccccgctc tttgctgggaccgagcactgcacctctctgattgactctacactgcagaccatatatagg ctctccaagggacgcgccctcaccaaagcgcagagggacaccatagaagaatgtttgctt gccatttgcaatcacttgaggccttccatgttacaacagctcctacgacgtctggttttt gatgttccacagctcaatgaatactgcaaaatgcctctgaagcttctgacgaatcactat gagcagtgctggaagtattactgtctgccttcaggatgggggagctacgggctggccatg gaggaggagttgcacctcacagagaagctcttctgggggatttttgactccctctcccat aagaaatatgacccagatctgttccgaatggccttgccctgtctcagtgctattgctggg gccttgccaccagattatttagataccagaatcacagccacattggagaaacaagtctct gtggatgcagatggcaactttgaccccaaacccatcaacacaatgaatttttccttgcct gaaaaattggaatacatcgtcaccaagtatgctgagcattcacatgataaatgggcctgt gacaagagtcagagtggatggagatatggaatttccctagatgaaaacatgaagacccac ccactgataaggcctttcaagacattaacggaaaaggagaaagaaatttatcgttggccg gccagagagtctctgaaaaccatgctggctgtgggctggactgtggagaggacaaaagag ggagaagctttggttcagcaacgagaaaatgagaaactccgcagtgtgtcccagactggc cagggcaacagctacagccctgctccccttgacctctcaaatgttgcactctccagagag ctccagggaatggtggaggtagtggctgagaactatcacaatatctgggccaaaaagaag aagctggaactggagagcaaaggaggtggcagtcaccctcttttggtaccatatgatacc ttgactgcaaaggaaaagttcagggaccgagagaaggcacaggacctgtttaagttcctc caggtgaatggcattatagtttccagaggtatgaagggtatggagatggatacctcctcc atggaaaagaggtttgcctacaaatttttgaagaagatcctgaaatacgttgattctgct caagaatttattgctcacttggaagccattgtcagcagtggaaaaactgaaaagtctcca catgaccaagagatcaaattctttgccaaagttctcctcccactagttgaccagtacttc accaatcaccacctctattttctgtcatctcctctgaagcccctcagtagcagtggttat gcctctcataaggagaaagaaatggtggccagcctgttctgcaaactcgctgctcttgtt agacacaggatttccctcttcgggagtgattctgctacaatggtgagctgtcttcacatc ttagctcagacacttgacacaaggacagtcatgaagtcaggctcagagctggtgaaggct gggttgcgaggattctttgaaaatgccgcagaagacttagagaagacgtcggaaaacctg aagcttgggaagtttactcattccagaacgcagatcaaaggggtttcccagaatatcaat tataccacagcggccctgctccccatcctgacgtctatcttcgagcatgtcgctcagcat cagtttggggtggatctcctcttgaacgatgtgcagatttcatgctaccacatactgtgc agcctttactctcttgggacaggaaaaaacatctatgttgaaaggcaacgccctgccctt ggagaatgtctggcttccctggcagcagccataccagtggcatttctggagcccaccctt aaccgctataatcctctctcggttttcaacaccaaaacccccagggagagatctattcta gggatgccagacacggtggaagagatgtgtcctgacctcccccagctggatggtctcatg aaggaaatcaacgagttggctgagtctggggcccgctacacagagatgccccacgtcatc gaggtgatcttgcccatgctctgcaactacctgtcctactggtgggagcgggggcctgag aacctgccccccagcacagggccctgctgcaccaaggtcacctctgaacacctcagcctc atcctgggcaacatcctgaaaataatcaacaacaacctaggcattgacgaggcctcttgg atgaaacggattgcagtgttcgcccagccaatcatcagcaaagccaggcctgacctgctg cgaacccacttcatcccgactctggagaagctgaaaaagaaggctgtcaagaccgtgcaa gaggaggagcagctgaaagctgatggcaaaggggatacccaggaggcagagctgctcatc ctggatgagtttgcagtcctctgcagagatctctatgccttctaccctatgctgatccgc tacgtggacaacaacagatcaaactggctcaaaagcccagatgatgattctgaccagctc ttccgaatggtggccgaggtcttcatcctgtggtgtaaatctcataacttcaaaagggaa gaacaaaattttgtgattcaaaatgaaattaacaatttggcatttttaactggagacagc aaaagcaagatgtcaaaagccatgcaagtaaagtctggaggacaggaccaggaacggaag aagacaaagcggaggggagacttgtattccatccagacctccctcatcgtggctgcactc aagaaaatgctgcccattggtctgaatatgtgcactccaggcgaccaggagctgatctcc cttgcaaaatcacgatacagctgtagggacacagatgaagaggtcaaggagcatcttcgg aataacctgcacttgcaggagaagtctgatgacccagccgtaaaatggcagctgaacctc tacaaggatgttctgaggagtgaagaacctgctactcccgagaagacagtggagcgtgtg cagagaatttcagcagctgtcttccacctggagcaggtggaacagcctttgagatccaag aaggctgtctggtacaaattattgtcaaagcaacggaaacgagcagtggtggcctgtttc aggatggctcctctctacaacctgcccaggcaccgctctattaacctcttcctccatggc tatcagagattttggatagaaacagaggcacattcctttgaagagaaactagtacaggat ttggctaaatcccccaaggcggaagaggaggaggaggaagagacggaaaaccagcctgac ccacttcatcaaatcattctccattttagtcgcaatgctctcacagagaggagcaaactg gaagatgaccctttgtacacctcctattccagcatgatggccaagagctgtcagagtgat gaggatgaagaagaggaagacaaggaaaaaacatttgaagaaaaagagatggagaagcag aaaaccctctatcagcaggctcggctgcatgagcgtggcgctgcagagatggtcctgcag atgctaagtgccagcaaaggtgagatgagccccatggtggttgagactctgaagctgggg atcgctgtcctgaatggaggcaacactggtgtccagcagaaaatgctagattatttaaag gagaaaaaagatgctggattctttcaaagcctttctggtcttatgcagtcttgcagtgtc cttgatttgaatgcatttgagagacagaataaagctgaaggcctggggatggttacagaa gaaggaacactcattgttcgtgagcgtggtgaaaaagtactccagaacgatgagttcaca cgagatctctttagattcctacagttactttgtgaaggacataacagtgactttcagaac ttcctgcggactcagatgggcaataccaccaccgtgaacatcatcatcagcaccgtggac tacctgctgcgtctgcaggaatcaatcagtgatttctactggtactattcagggaaggac atcattgatgaatctggacagcacaatttttctaaagctctagcagtcaccaagcagatt ttcaattctcttacggagtatatccagggcccttgcattgggaaccagcagagtctggct cacagcaggctgtgggacgcagtggtcggcttcctccatgtatttgctaacatgcagatg aaactctctcaggattccagtcagatcgagctgctgaaggaactcttggatctccttcag gacatggtggtgatgcttctgtccctcctggaagggaatgtggtaaatggaactattggc aagcaaatggttgacacactggtagaatcgtctactaatgtagaaatgatcttgaaattc tttgacatgttcttgaaacttaaagacttaaccagctcagacaccttcaaagaatatgac ccagatggtaaagggatcatctctaaaaaagaattccagaaagccatggaagggcaaaag cagtacacacagtcagagatagactttctcctgtcgtgtgcagaagctgatgaaaatgac atgtttaattacattgattttgtggaccggttccatgagcctgccaaggacatagggttt aatgtggcagtgttactgacaaatctttctgaacatatgcctaatgattctcgcctgaag tgtctcttggaccccgcagaaagtgtgctcaattacttcgaaccatatctaggacgaatt gagatcatgggtggggccaagaaaattgaacgtgtttatttcgagatcagtgaatccagt agaactcagtgggagaagcctcaagtgaaggaatctaagcggcagttcatctttgatgtt gtcaacgaaggtggggagcaagaaaagatggagctatttgtgaacttctgtgaggacacc atctttgagatgcaattggcatctcagatctcggaatccgattcagctgacaggccagaa gaagaggagaaagaaagtgaagagtcttcatatgtgctagaaatggagggtgaggaggag gaagacaagtctttcgagcctgcctctgcatttgccatggcctgtgcctcggcaaaaaga aatgtttccaacctcctaaagaaggcaaccctgaaaaacctcaggaagcagtaccggaat gtgaaaaagatgactgcaaaggagctggtaaaggtgttcttctccttttactggatgttt ttcgtggggctattccagatgttcttcaccatattaggaggaatctttcagatcctctgg aatacagtatttggaggaggcctcgtagaaggggcaaaaaacatcagagtgaccaagatc ctgggtgacatgccggatccaacccagtttgggatccatgatgatgccatggaggctgaa agggcagaagtggttgaaccaggtctcaccgctgagctagtgcattgcatgaaaggtgag aagggagacacagacatcatgtcagacctctttggacttcacccaaagaaagaaggtggc ctaaagcatgggcatgaagtgggtttgggtgacctctctgaaattattggcaaggatgag ccccctactttagagaatactgtgcagaaaaaaaggaaagcacaggcagcagagatgaag gcagcacatgaagtggaaggaaaagtagaatctgagaaagcagacatggaaggcagagaa aaggaggacaaagccaaagaggaagagcaagccaagtatctgtgggcagaagtgacaaag aaaaagaagcgatggcgtagtcagaaggctgagaaacctgaagccttcatggccaatttc tttaaagggctggacatctatcagaccaagttactgcattacctggccagaaatttctac aacctgaggttccttgctctgtttgtagccttcgctatcaacttcatcctgcttttttat aaggtcactgaagaacctctagaggaagagaccgaggatgtggcgaacctatggaattcc tttaatgatgaggaagaggaagaagccatggtgttctttgtcctgcaggagagcaccggg tatatggctccaacactgcgggcactggctgttgtccataccatcatctcgcttgtctgt gtcatgggctattactgcctaaaggtccctttggcggtattcaaaagggaaaaagaaatt gccaggaagctggagtttgatggcctgtatatcactgagcagccgtctgaggacgacatc aaggggcagtgggaccgcttagtcatcaacacaccatcctttcctaataactactgggac aagtttgtgaagagaaaggtgatcaacaagtatggagatctctacggagcagagcgcatt gctgaactcctgggcttggacaaaaatgcccttgactttagcccagtggaagagaccaaa gcagaggcagcttctctggtgtcatggctgagttccgtcgacatgaaataccatatctgg aagctgggggttgttttcactgacaattccttcctctaccttgcttggtacacaaccatg tcaatcctggggcactacaacaacttcttctttgctgctcatttattggatatcgcaatg ggcttcaagaccttgaggactattctgtcatctgtaactcacaatggcaaacagctggtt ctgaccgtcggtctcttggcagtggtggtttacctctacacggtggtggccttcaacttc ttccgtaagttctacaacaaaagtgaagatgacgatgagcccgacatgaagtgtgatgac atgatgacgtgttaccttttccacatgtatgtgggagtgagagcaggaggcggcattggc gatgaaattgaagaccctgctggtgatccttacgaaatgtatcgcattgtctttgacatt acctttttcttctttgtcattgtcatcttgctggccatcattcaaggtcttattatcgat gcttttggagagctgagagaccagcaggaacaagtgcgagaggatatggagacgaaatgt ttcatctgtggcattggcaatgactactttgacacaacccctcatggttttgaaacacac acattacaagagcacaacttagccaactacttgttttttctcatgtatctgattaacaaa gatgaaacagagcacacgggtcaggaatcttatgtgtggaagatgtaccaagaaaggtgc tgggatttcttcccggctggcgactgctttcgtaagcaatacgaagatcagcttggataa

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