Homo sapiens (human): 100
Help
Entry
100 CDS
T01001
Symbol
ADA, ADA1
Name
(RefSeq) adenosine deaminase isoform 1
KO
K01488
adenosine deaminase [EC:
3.5.4.4
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00230
Purine metabolism
hsa01100
Metabolic pathways
hsa01232
Nucleotide metabolism
hsa05340
Primary immunodeficiency
Module
hsa_M00958
Adenine ribonucleotide degradation, AMP => Urate
Disease
H00092
T-B-Severe combined immunodeficiency
H02309
Adenosine deaminase deficiency
Drug target
Elapegademase:
D11017
<JP/US>
Pentostatin:
D00155
<US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
100 (ADA)
09160 Human Diseases
09163 Immune disease
05340 Primary immunodeficiency
100 (ADA)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.5.4 In cyclic amidines
3.5.4.4 adenosine deaminase
100 (ADA)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
A_deaminase
BBS2_CtH
Motif
Other DBs
NCBI-GeneID:
100
NCBI-ProteinID:
NP_000013
OMIM:
608958
HGNC:
186
Ensembl:
ENSP00000361965.4
UniProt:
P00813
A0A0S2Z381
Structure
PDB
PDBj
LinkDB
All DBs
Position
20:complement(44619522..44651699)
Genome browser
AA seq
363 aa
AA seq
DB search
MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPD
FLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQA
EGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAI
DLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGY
HTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIF
KSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAG
QNL
NT seq
1092 nt
NT seq
+upstream
nt +downstream
nt
atggcccagacgcccgccttcgacaagcccaaagtggaactgcatgtccacctagacgga
tccatcaagcctgaaaccatcttatactatggcaggaggagagggatcgccctcccagct
aacacagcagaggggctgctgaacgtcattggcatggacaagccgctcacccttccagac
ttcctggccaagtttgactactacatgcctgctatcgcgggctgccgggaggctatcaaa
aggatcgcctatgagtttgtagagatgaaggccaaagagggcgtggtgtatgtggaggtg
cggtacagtccgcacctgctggccaactccaaagtggagccaatcccctggaaccaggct
gaaggggacctcaccccagacgaggtggtggccctagtgggccagggcctgcaggagggg
gagcgagacttcggggtcaaggcccggtccatcctgtgctgcatgcgccaccagcccaac
tggtcccccaaggtggtggagctgtgtaagaagtaccagcagcagaccgtggtagccatt
gacctggctggagatgagaccatcccaggaagcagcctcttgcctggacatgtccaggcc
taccaggaggctgtgaagagcggcattcaccgtactgtccacgccggggaggtgggctcg
gccgaagtagtaaaagaggctgtggacatactcaagacagagcggctgggacacggctac
cacaccctggaagaccaggccctttataacaggctgcggcaggaaaacatgcacttcgag
atctgcccctggtccagctacctcactggtgcctggaagccggacacggagcatgcagtc
attcggctcaaaaatgaccaggctaactactcgctcaacacagatgacccgctcatcttc
aagtccaccctggacactgattaccagatgaccaaacgggacatgggctttactgaagag
gagtttaaaaggctgaacatcaatgcggccaaatctagtttcctcccagaagatgaaaag
agggagcttctcgacctgctctataaagcctatgggatgccaccttcagcctctgcaggg
cagaacctctga
Homo sapiens (human): 144811
Help
Entry
144811 CDS
T01001
Symbol
LACC1, C13orf31, FAMIN, JUVAR
Name
(RefSeq) purine nucleoside phosphorylase LACC1 isoform 1
KO
K05810
purine-nucleoside/S-methyl-5'-thioadenosine phosphorylase / adenosine deaminase [EC:
2.4.2.1
2.4.2.28
3.5.4.4
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00230
Purine metabolism
hsa00270
Cysteine and methionine metabolism
hsa01100
Metabolic pathways
hsa01232
Nucleotide metabolism
Module
hsa_M00034
Methionine salvage pathway
hsa_M00958
Adenine ribonucleotide degradation, AMP => Urate
hsa_M00959
Guanine ribonucleotide degradation, GMP => Urate
Network
nt06027
Purine salvage pathway
Element
N01418
Purine salvage pathway, adenine to AMP
N01421
Purine salvage pathway, hypoxanthine/guanine to IMP/GMP
Disease
H01672
Juvenile idiopathic arthritis
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
144811 (LACC1)
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
144811 (LACC1)
Enzymes [BR:
hsa01000
]
2. Transferases
2.4 Glycosyltransferases
2.4.2 Pentosyltransferases
2.4.2.1 purine-nucleoside phosphorylase
144811 (LACC1)
2.4.2.28 S-methyl-5'-thioadenosine phosphorylase
144811 (LACC1)
3. Hydrolases
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.5.4 In cyclic amidines
3.5.4.4 adenosine deaminase
144811 (LACC1)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Cu-oxidase_4
Motif
Other DBs
NCBI-GeneID:
144811
NCBI-ProteinID:
NP_001121775
OMIM:
613409
HGNC:
26789
UniProt:
Q8IV20
LinkDB
All DBs
Position
13:43879178..43893932
Genome browser
AA seq
430 aa
AA seq
DB search
MAEAVLIDLFGLKLNSQKNCHQTLLKTLNAVQYHHAAKAKFLCIMCCSNISYERDGEQDN
CEIETSNGLSALLEEFEIVSCPSMAATLYTIKQKIDEKNLSSIKVIVPRHRKTLMKAFID
QLFTDVYNFEFEDLQVTFRGGLFKQSIEINVITAQELRGIQNEIETFLRSLPALRGKLTI
ITSSLIPDIFIHGFTTRTGGISYIPTLSSFNLFSSSKRRDPKVVVQENLRRLANAAGFNV
EKFYRIKTHHSNDIWIMGRKEPDSYDGITTNQRGVTIAALGADCIPIVFADPVKKACGVA
HAGWKGTLLGVAMATVNAMIAEYGCSLEDIVVVLGPSVGPCCFTLPRESAEAFHNLHPAC
VQLFDSPNPCIDIRKATRILLEQGGILPQNIQDQNQDLNLCTSCHPDKFFSHVRDGLNFG
TQIGFISIKE
NT seq
1293 nt
NT seq
+upstream
nt +downstream
nt
atggcagaagctgttttgattgatctttttggtttgaaattgaactctcaaaaaaactgc
catcagacattactgaagactttgaatgctgtccaataccaccatgctgccaaggccaag
tttctctgtataatgtgttgcagtaacatcagctatgaaagggatggagaacaagataat
tgtgaaatagaaacaagcaatggattatcagctctcttggaagaatttgagattgttagc
tgtcccagcatggctgccactttgtataccattaaacagaaaattgatgaaaaaaatctg
agcagcattaaggtaattgtacccaggcacaggaagacattaatgaaagcttttattgat
caactcttcactgatgtttacaattttgaatttgaagatttgcaagtgacttttagggga
gggctttttaaacagtccattgaaataaacgtaatcacagctcaagaactaagaggaatt
cagaatgaaatagaaacatttttgagaagtctgccagcactgagaggaaaattaactatt
atcacttcttctttgatcccagatattttcatacatggatttactacaagaacaggtggg
atatcttatataccaactcttagctcattcaatctcttcagtagttccaaacggagagat
cccaaggtagtggttcaagaaaatctgcgtaggttggcgaatgctgcaggatttaatgtg
gagaaattttaccgaataaagactcatcattccaatgacatctggattatgggaagaaag
gagcctgactcttatgatggaataaccacaaatcagagaggagtcacaatagcagctctt
ggtgcagactgtataccgatagtttttgcagatccagtcaaaaaagcatgtggggttgct
cacgctggttggaaaggtactttgttgggtgttgctatggctacagtgaatgctatgata
gcagaatatggctgcagtttggaagacattgttgttgtacttggaccttcagtaggacct
tgctgttttactcttccaagggaatcagcagaggcatttcataatcttcatcctgcatgt
gtacaactatttgattcaccaaatccctgtatcgacatccgtaaagccacaaggattctt
ctagaacagggaggaattcttccacagaatattcaggaccagaaccaagatctcaacctc
tgtacatcttgccatcctgacaagtttttctcccatgtccgagatggccttaattttggt
acacagattggcttcatatcaattaaagaatga
Homo sapiens (human): 51816
Help
Entry
51816 CDS
T01001
Symbol
ADA2, ADGF, CECR1, IDGFL, PAN, SNEDS, VAIHS
Name
(RefSeq) adenosine deaminase 2 isoform a precursor
KO
K19572
adenosine deaminase CECR1 [EC:
3.5.4.4
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00230
Purine metabolism
hsa01100
Metabolic pathways
hsa01232
Nucleotide metabolism
Module
hsa_M00958
Adenine ribonucleotide degradation, AMP => Urate
Disease
H01382
Polyarteritis nodosa
H02883
Sneddon syndrome
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
51816 (ADA2)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.5.4 In cyclic amidines
3.5.4.4 adenosine deaminase
51816 (ADA2)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
A_deaminase
A_deaminase_N
AMP_deaminase
CSM2
DUF5630
Motif
Other DBs
NCBI-GeneID:
51816
NCBI-ProteinID:
NP_001269154
OMIM:
607575
HGNC:
1839
Ensembl:
ENSP00000382731.2
UniProt:
Q9NZK5
Structure
PDB
PDBj
LinkDB
All DBs
Position
22:complement(17178790..17221848)
Genome browser
AA seq
511 aa
AA seq
DB search
MLVDGPSERPALCFLLLAVAMSFFGSALSIDETRAHLLLKEKMMRLGGRLVLNTKEELAN
ERLMTLKIAEMKEAMRTLIFPPSMHFFQAKHLIERSQVFNILRMMPKGAALHLHDIGIVT
MDWLVRNVTYRPHCHICFTPRGIMQFRFAHPTPRPSEKCSKWILLEDYRKRVQNVTEFDD
SLLRNFTLVTQHPEVIYTNQNVVWSKFETIFFTISGLIHYAPVFRDYVFRSMQEFYEDNV
LYMEIRARLLPVYELSGEHHDEEWSVKTYQEVAQKFVETHPEFIGIKIIYSDHRSKDVAV
IAESIRMAMGLRIKFPTVVAGFDLVGHEDTGHSLHDYKEALMIPAKDGVKLPYFFHAGET
DWQGTSIDRNILDALMLNTTRIGHGFALSKHPAVRTYSWKKDIPIEVCPISNQVLKLVSD
LRNHPVATLMATGHPMVISSDDPAMFGAKGLSYDFYEVFMGIGGMKADLRTLKQLAMNSI
KYSTLLESEKNTFMEIWKKRWDKFIADVATK
NT seq
1536 nt
NT seq
+upstream
nt +downstream
nt
atgttggtggatggcccatctgagcggccagccctgtgcttcttgctgttggctgtggca
atgtctttcttcggctcagctctatccatagatgaaacacgggcgcatctgttgttgaaa
gaaaagatgatgcggctgggggggcggctggtgctgaacaccaaggaggagctggccaat
gagaggctcatgacgctcaaaatcgctgagatgaaggaggccatgaggaccctgatattc
ccacccagcatgcactttttccaggccaagcatctcattgagagaagtcaagtgtttaat
attctaaggatgatgccaaaaggggctgccttgcacctccatgacattggcatcgtgact
atggactggctggtgaggaatgtcacctacaggcctcactgccacatctgtttcacccca
agggggatcatgcagttcagatttgctcacccaactccccgtccatcagaaaaatgttcc
aagtggattctgctggaggattatcggaagcgggtgcagaacgtcactgagtttgatgac
agcttgctgaggaatttcactctggtgacccagcacccggaggtgatttacacaaaccaa
aatgttgtctggtcgaaatttgaaaccatcttcttcaccatctctggtctcatccattac
gcaccagtgttcagagactatgtcttccggagcatgcaggagttctacgaggacaacgtg
ctctacatggagatcagagccaggctgctgccggtgtatgagctcagtggagagcaccat
gacgaagagtggtcagtgaagacttaccaggaagtagctcagaagtttgtggaaactcac
cctgagtttattggaatcaaaatcatttattcggatcacagatccaaagatgtggctgtc
atcgcagaatccatccgaatggccatggggctccgaatcaagttccccacggtggtggca
gggtttgacctggtggggcatgaggacactggccactccttgcatgactacaaggaagct
ctgatgatccccgccaaggatggcgttaagctgccttacttcttccacgccggagaaaca
gactggcagggtacttccatagacaggaacattctggatgctctgatgctgaacactacc
agaatcggccatggatttgctttgagcaaacaccccgcagtcaggacttactcctggaaa
aaggacatccccatagaagtctgtcccatctctaaccaggtgctgaaactggtgtctgac
ttgaggaaccaccctgtagccactctgatggccactgggcaccccatggtgatcagctct
gatgacccagctatgtttggtgccaaaggcttgtcctatgatttctatgaggtcttcatg
ggcattggggggatgaaggctgacctgaggaccctcaaacagctggccatgaactctatc
aagtacagtaccctgttggagagtgagaaaaatactttcatggaaatctggaagaagaga
tgggataagttcatagcagatgtggctacaaagtga
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integrated database retrieval system
