KEGG   Homo sapiens (human): 100
Entry
100               CDS       T01001                                 
Symbol
ADA, ADA1
Name
(RefSeq) adenosine deaminase isoform 1
  KO
K01488  adenosine deaminase [EC:3.5.4.4]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00230  Purine metabolism
hsa01100  Metabolic pathways
hsa01232  Nucleotide metabolism
hsa05340  Primary immunodeficiency
Module
hsa_M00958  Adenine ribonucleotide degradation, AMP => Urate
Disease
H00092  T-B-Severe combined immunodeficiency
H02309  Adenosine deaminase deficiency
Drug target
Elapegademase: D11017<JP/US>
Pentostatin: D00155<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    100 (ADA)
 09160 Human Diseases
  09163 Immune disease
   05340 Primary immunodeficiency
    100 (ADA)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.4  adenosine deaminase
     100 (ADA)
SSDB
Motif
Pfam: A_deaminase BBS2_CtH
Other DBs
NCBI-GeneID: 100
NCBI-ProteinID: NP_000013
OMIM: 608958
HGNC: 186
Ensembl: ENSP00000361965.4
UniProt: P00813 A0A0S2Z381
Structure
LinkDB
Position
20:complement(44619522..44651699)
AA seq 363 aa
MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPD
FLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQA
EGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAI
DLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGY
HTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIF
KSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAG
QNL
NT seq 1092 nt   +upstreamnt  +downstreamnt
atggcccagacgcccgccttcgacaagcccaaagtggaactgcatgtccacctagacgga
tccatcaagcctgaaaccatcttatactatggcaggaggagagggatcgccctcccagct
aacacagcagaggggctgctgaacgtcattggcatggacaagccgctcacccttccagac
ttcctggccaagtttgactactacatgcctgctatcgcgggctgccgggaggctatcaaa
aggatcgcctatgagtttgtagagatgaaggccaaagagggcgtggtgtatgtggaggtg
cggtacagtccgcacctgctggccaactccaaagtggagccaatcccctggaaccaggct
gaaggggacctcaccccagacgaggtggtggccctagtgggccagggcctgcaggagggg
gagcgagacttcggggtcaaggcccggtccatcctgtgctgcatgcgccaccagcccaac
tggtcccccaaggtggtggagctgtgtaagaagtaccagcagcagaccgtggtagccatt
gacctggctggagatgagaccatcccaggaagcagcctcttgcctggacatgtccaggcc
taccaggaggctgtgaagagcggcattcaccgtactgtccacgccggggaggtgggctcg
gccgaagtagtaaaagaggctgtggacatactcaagacagagcggctgggacacggctac
cacaccctggaagaccaggccctttataacaggctgcggcaggaaaacatgcacttcgag
atctgcccctggtccagctacctcactggtgcctggaagccggacacggagcatgcagtc
attcggctcaaaaatgaccaggctaactactcgctcaacacagatgacccgctcatcttc
aagtccaccctggacactgattaccagatgaccaaacgggacatgggctttactgaagag
gagtttaaaaggctgaacatcaatgcggccaaatctagtttcctcccagaagatgaaaag
agggagcttctcgacctgctctataaagcctatgggatgccaccttcagcctctgcaggg
cagaacctctga

KEGG   Homo sapiens (human): 51816
Entry
51816             CDS       T01001                                 
Symbol
ADA2, ADGF, CECR1, IDGFL, PAN, SNEDS, VAIHS
Name
(RefSeq) adenosine deaminase 2 isoform a precursor
  KO
K19572  adenosine deaminase CECR1 [EC:3.5.4.4]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00230  Purine metabolism
hsa01100  Metabolic pathways
hsa01232  Nucleotide metabolism
Module
hsa_M00958  Adenine ribonucleotide degradation, AMP => Urate
Disease
H01382  Polyarteritis nodosa
H02883  Sneddon syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    51816 (ADA2)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.4  adenosine deaminase
     51816 (ADA2)
SSDB
Motif
Pfam: A_deaminase A_deaminase_N AMP_deaminase CSM2 DUF5630
Other DBs
NCBI-GeneID: 51816
NCBI-ProteinID: NP_001269154
OMIM: 607575
HGNC: 1839
Ensembl: ENSP00000382731.2
UniProt: Q9NZK5
Structure
LinkDB
Position
22:complement(17178790..17221848)
AA seq 511 aa
MLVDGPSERPALCFLLLAVAMSFFGSALSIDETRAHLLLKEKMMRLGGRLVLNTKEELAN
ERLMTLKIAEMKEAMRTLIFPPSMHFFQAKHLIERSQVFNILRMMPKGAALHLHDIGIVT
MDWLVRNVTYRPHCHICFTPRGIMQFRFAHPTPRPSEKCSKWILLEDYRKRVQNVTEFDD
SLLRNFTLVTQHPEVIYTNQNVVWSKFETIFFTISGLIHYAPVFRDYVFRSMQEFYEDNV
LYMEIRARLLPVYELSGEHHDEEWSVKTYQEVAQKFVETHPEFIGIKIIYSDHRSKDVAV
IAESIRMAMGLRIKFPTVVAGFDLVGHEDTGHSLHDYKEALMIPAKDGVKLPYFFHAGET
DWQGTSIDRNILDALMLNTTRIGHGFALSKHPAVRTYSWKKDIPIEVCPISNQVLKLVSD
LRNHPVATLMATGHPMVISSDDPAMFGAKGLSYDFYEVFMGIGGMKADLRTLKQLAMNSI
KYSTLLESEKNTFMEIWKKRWDKFIADVATK
NT seq 1536 nt   +upstreamnt  +downstreamnt
atgttggtggatggcccatctgagcggccagccctgtgcttcttgctgttggctgtggca
atgtctttcttcggctcagctctatccatagatgaaacacgggcgcatctgttgttgaaa
gaaaagatgatgcggctgggggggcggctggtgctgaacaccaaggaggagctggccaat
gagaggctcatgacgctcaaaatcgctgagatgaaggaggccatgaggaccctgatattc
ccacccagcatgcactttttccaggccaagcatctcattgagagaagtcaagtgtttaat
attctaaggatgatgccaaaaggggctgccttgcacctccatgacattggcatcgtgact
atggactggctggtgaggaatgtcacctacaggcctcactgccacatctgtttcacccca
agggggatcatgcagttcagatttgctcacccaactccccgtccatcagaaaaatgttcc
aagtggattctgctggaggattatcggaagcgggtgcagaacgtcactgagtttgatgac
agcttgctgaggaatttcactctggtgacccagcacccggaggtgatttacacaaaccaa
aatgttgtctggtcgaaatttgaaaccatcttcttcaccatctctggtctcatccattac
gcaccagtgttcagagactatgtcttccggagcatgcaggagttctacgaggacaacgtg
ctctacatggagatcagagccaggctgctgccggtgtatgagctcagtggagagcaccat
gacgaagagtggtcagtgaagacttaccaggaagtagctcagaagtttgtggaaactcac
cctgagtttattggaatcaaaatcatttattcggatcacagatccaaagatgtggctgtc
atcgcagaatccatccgaatggccatggggctccgaatcaagttccccacggtggtggca
gggtttgacctggtggggcatgaggacactggccactccttgcatgactacaaggaagct
ctgatgatccccgccaaggatggcgttaagctgccttacttcttccacgccggagaaaca
gactggcagggtacttccatagacaggaacattctggatgctctgatgctgaacactacc
agaatcggccatggatttgctttgagcaaacaccccgcagtcaggacttactcctggaaa
aaggacatccccatagaagtctgtcccatctctaaccaggtgctgaaactggtgtctgac
ttgaggaaccaccctgtagccactctgatggccactgggcaccccatggtgatcagctct
gatgacccagctatgtttggtgccaaaggcttgtcctatgatttctatgaggtcttcatg
ggcattggggggatgaaggctgacctgaggaccctcaaacagctggccatgaactctatc
aagtacagtaccctgttggagagtgagaaaaatactttcatggaaatctggaagaagaga
tgggataagttcatagcagatgtggctacaaagtga

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