Homo sapiens (human): 10019 Help Entry 10019             CDS       T01001                                  Symbol SH2B3, IDDM20, LNK Name (RefSeq) SH2B adaptor protein 3   KO K12459   SH2B adaptor protein 1/3 Organism hsa  Homo sapiens (human) Pathway hsa04722   Neurotrophin signaling pathway Disease H00236   Congenital polycythemia H00408   Type 1 diabetes mellitus H01605   Myelofibrosis H01612   Essential thrombocytosis Brite KEGG Orthology (KO) [BR:hsa00001]  09150 Organismal Systems   09156 Nervous system    04722 Neurotrophin signaling pathway     10019 (SH2B3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Phe_ZIP SH2 PH Motif Other DBs NCBI-GeneID:  10019 NCBI-ProteinID:  NP_005466 OMIM:  605093 HGNC:  29605 Ensembl:  ENSG00000111252 Pharos:  Q9UQQ2(Tbio) UniProt:  Q9UQQ2 Q59H48 LinkDB All DBs Position 12:111404730..111451623 Genome browser AA seq 575 aa AA seqDB search MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRA ELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARS SEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAK KFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELF DPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMA ELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLS CYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTE RGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFS LPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQ HLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL NT seq 1728 nt NT seq  +upstreamnt  +downstreamnt atgaacgggcctgccctgcagccctcctcgccctcttccgcgccctcagcctccccggcg gcggccccgcggggctggagcgagttctgtgagttgcacgccgtagcggcggcccgggag ctggcccgccagtactggctgttcgcccgggagcatccgcagcacgcgccgctgcgcgcc gagctggtgtcgctgcagttcaccgacctcttccagcgctacttctgccgcgaggtgcgc gacggacgggcgccgggccgcgactaccgggacacaggccgtgggcccccagccaaggcc gaggcgtccccggagccaggccccggccccgccgcccctggcctgcccaaggcccgcagc tctgaggagctggccccgccgcggccgcccgggccctgctccttccagcactttcgccgc agcctccgccacatcttccgccgccgctcggccggggagctgccagcggcccacaccgct gccgcccccgggacccccggagaggctgctgagacccccgcccggcctggcctggccaag aagttcctgccctggagcctggcccgggagccgccacccgaggcgctgaaggaggcggtg ctgcgctacagcctggccgacgaggcctccatggacagcggggcacgctggcagcgcggg aggctggcgctgcgccgggccccgggccccgatggccccgaccgcgtgctggagctcttc gacccacccaagagttcaaggcccaagctacaagcagcttgctccagcatccaggaggtc cggtggtgcacacggcttgagatgcctgacaacctttacacctttgtgctgaaggtgaag gaccggacagacatcatctttgaggtgggagacgagcagcagctgaattcatggatggct gagctctcggagtgcacaggccgagggctggagagcacagaagcagagatgcatattccc tcagccctagagcctagcacgtccagctccccaaggggcagcacagattcccttaaccaa ggtgcttctcctggggggctgctggacccggcctgccagaagacggaccatttcctgtcc tgctacccctggttccacggccccatctccagagtgaaagcagctcagctggttcagctg cagggccctgatgctcatggagtgttcctggtgcggcagagcgagacgcggcgtggggaa tacgtgctcactttcaactttcaggggatagccaagcacctgcgcctgtcgctgacagag cggggccagtgccgtgtgcagcacctccactttccctcggtcgtggacatgctccaccac ttccagcgctcgcccatcccactcgagtgcggcgccgcctgtgatgtccggctctccagc tacgtggtagtcgtctcccaaccaccaggttcctgcaacacggtcctcttccctttctcc cttcctcactgggattcagagtcccttcctcactggggttcagagttgggccttccccac cttagttcttctggctgtccccgggggctcagcccagagggtctcccagggcgatcctca ccccccgagcagatcttccacctggtgccttcgcccgaagaactggccaacagcctgcag cacctggagcatgagcctgtgaatcgagcccgggactcggactacgaaatggactcatcc tcccggagccacctgcgggccatagacaatcagtacacacctctctga

Homo sapiens (human): 25970 Help Entry 25970             CDS       T01001                                  Symbol SH2B1, PSM, SH2B Name (RefSeq) SH2B adaptor protein 1   KO K12459   SH2B adaptor protein 1/3 Organism hsa  Homo sapiens (human) Pathway hsa04722   Neurotrophin signaling pathway Brite KEGG Orthology (KO) [BR:hsa00001]  09150 Organismal Systems   09156 Nervous system    04722 Neurotrophin signaling pathway     25970 (SH2B1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Phe_ZIP SH2 PH PI3K_rbd Motif Other DBs NCBI-GeneID:  25970 NCBI-ProteinID:  NP_001139267 OMIM:  608937 HGNC:  30417 Ensembl:  ENSG00000178188 Pharos:  Q9NRF2(Tbio) UniProt:  Q9NRF2 A0A024QZD2 B4DLN5 B3KNV5 Structure PDB LinkDB All DBs Position 16:28846606..28874205 Genome browser AA seq 756 aa AA seqDB search MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQEPTTSHDPPQPPEPPSWTDPPQPGAEEA SRAPEVAAAAAAAAKERQEKEKAGGGGVPEELVPVVELVPVVELEEAIAPGSEAQGAGSG GDAGVPPMVQLQQSPLGGDGEEGGHPRAINNQYSFV NT seq 2271 nt NT seq  +upstreamnt  +downstreamnt atgaatggtgccccttccccagaggacggggcctccccctcgtctcccccgctgccccca cccccgccccctagttggcgggagttctgtgagtcccacgcccgggctgcggctctggac tttgcccgccgttttcgcctctacctggcctcccacccccaatatgcggggcccggggcc gaggctgccttctcccgccgttttgctgagctcttcctgcagcactttgaagccgaggtg gcccgggcctctggctccctgtcgccacccatcctggctcccctgagccctggtgcggag atttcgccacatgacctgtcccttgagagctgcagggtgggtgggcccctggctgtgctg ggcccttctcgatcatctgaggacctggccggccccctcccttcctcagtctcttcctcc tctacaacctcctccaagccgaagctcaagaagcgcttttccctgcgttcagtgggtcgc tctgtccgaggctcagtccgtggcatcctgcagtggcgggggaccgttgaccctccctcc tccgctgggcccctggagacctcgtcaggccccccagtcttaggtggaaacagcaactcc aactcctctggcggggctgggaccgttggtaggggactggtcagtgatggaacgtcccct ggggaaagatggactcaccgttttgagaggctgagactcagtcggggagggggcgccttg aaggatggagcagggatggtgcagagggaagagctgctgagtttcatgggggctgaggag gcagcccctgacccagccggagtgggccggggaggaggggtggctgggcctccttcaggg ggaggagggcagcctcagtggcagaagtgtcgcctgctgcttcgaagtgaaggagaagga ggaggaggaagtcgcctggagttctttgtaccacccaaggcctctcggccccgactcagc atcccctgctcttctatcacagacgtccggacaaccacagccctggagatgcctgaccgg gagaacacgtttgtggttaaggtggaaggtccatccgagtatatcatggagacagtggat gcccagcatgtgaaggcctgggtgtctgacatccaagaatgcctgagcccaggaccctgc cctgctaccagtccccgccccatgaccctccctctggcccctgggacctcattccttaca agggagaacacagacagcctggagctgtcctgcctgaatcactcggagagtctacccagc caggacctgctgcttggacccagcgagagcaatgaccgcctgtcgcagggggcatatggg ggcctctcagaccgcccctcggcatccatctcccccagctctgcctccattgccgcctcc cattttgactcgatggaactgcttcccccagagttgcccccccgcatccccattgaagag ggacccccaacagggacagttcatcccctctcagccccctaccctcccttggacactccg gaaacagccacagggtccttcctgttccagggggagccagagggcggtgagggggaccag cccctctcagggtatccttggttccacgggatgctctctcggctcaaggctgcacagttg gtgctgactggcggcactggctcccacggtgtcttcctggtgcgccagagtgagacaagg cggggtgaatacgtcctcaccttcaacttccagggcaaggccaagcacctgcgtttgtcg ctgaacgaggagggtcagtgccgggtccagcacctgtggttccagtccattttcgatatg ctcgagcacttccgggtgcaccccatccctttggagtcgggaggctccagtgatgttgtc cttgtcagctatgtcccatcctcccagcgacagcaggaaccgaccacctcccatgaccca ccccagccccctgaacccccttcatggacagatcccccacagcctggggcagaagaggcg tcgagggcgccagaagtggcggcagcagcagccgcagcagccaaagagaggcaagagaaa gagaaagcgggcggtggaggggtcccggaagagctggtccccgtggttgagctggtcccc gtggttgaattggaagaggccatagccccaggctcagaggcccagggcgctgggtctggt ggggacgcgggggtgcccccaatggtgcagctgcagcagtcaccactagggggtgatgga gaggaagggggccaccccagggccattaacaaccagtactccttcgtgtga

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