KEGG T01001: 10148

Homo sapiens (human): 10148

Entry

10148             CDS       T01001

Symbol

EBI3, IL-27B, IL27B, IL35B

Name

(RefSeq) Epstein-Barr virus induced 3

K24476

interleukin 27 subunit beta

Organism

hsa Homo sapiens (human)

Pathway

hsa04060

Cytokine-cytokine receptor interaction

hsa04659

Th17 cell differentiation

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    10148 (EBI3)
09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    10148 (EBI3)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    10148 (EBI3)
Cytokines and neuropeptides [BR:hsa04052]
Cytokines
  Interleukins
   10148 (EBI3)

SSDB

Motif

Pfam:

FN3_IL27B_N fn3 Ig_Rha78A_N

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

19:4229523..4237528

AA seq 229 aa
MTPQLLLALVLWASCPPCSGRKGPPAALTLPRVQCRASRYPIAVDCSWTLPPAPNSTSPV
SFIATYRLGMAARGHSWPCLQQTPTSTSCTITDVQLFSMAPYVLNVTAVHPWGSSSSFVP
FITEHIIKPDPPEGVRLSPLAERQLQVQWEPPGSWPFPEIFSLKYWIRYKRQGAARFHRV
GPIEATSFILRAVRPRARYYVQVAAQDLTDYGELSDWSLPATATMSLGK

NT seq 690 nt +upstreamnt +downstreamnt
atgaccccgcagcttctcctggcccttgtcctctgggccagctgcccgccctgcagtgga
aggaaagggcccccagcagctctgacactgccccgggtgcaatgccgagcctctcggtac
ccgatcgccgtggattgctcctggaccctgccgcctgctccaaactccaccagccccgtg
tccttcattgccacgtacaggctcggcatggctgcccggggccacagctggccctgcctg
cagcagacgccaacgtccaccagctgcaccatcacggatgtccagctgttctccatggct
ccctacgtgctcaatgtcaccgccgtccacccctggggctccagcagcagcttcgtgcct
ttcataacagagcacatcatcaagcccgaccctccagaaggcgtgcgcctaagccccctc
gctgagcgccagctacaggtgcagtgggagcctcccgggtcctggcccttcccagagatc
ttctcactgaagtactggatccgttacaagcgtcagggagctgcgcgcttccaccgggtg
gggcccattgaagccacgtccttcatcctcagggctgtgcggccccgagccaggtactac
gtccaagtggcggctcaggacctcacagactacggggaactgagtgactggagtctcccc
gccactgccacaatgagcctgggcaagtag

Homo sapiens (human): 3592

Entry

3592              CDS       T01001

Symbol

IL12A, CLMF, IL-12A, NFSK, NKSF1, P35

Name

(RefSeq) interleukin 12A

K05406

interleukin 12A

Organism

hsa Homo sapiens (human)

Pathway

hsa04060

Cytokine-cytokine receptor interaction

hsa04620

Toll-like receptor signaling pathway

hsa04622

RIG-I-like receptor signaling pathway

hsa04625

C-type lectin receptor signaling pathway

hsa04630

JAK-STAT signaling pathway

hsa04658

Th1 and Th2 cell differentiation

hsa04936

Alcoholic liver disease

hsa04940

Type I diabetes mellitus

hsa05133

Pertussis

hsa05134

Legionellosis

hsa05140

Leishmaniasis

hsa05142

Chagas disease

hsa05143

African trypanosomiasis

hsa05144

Malaria

hsa05145

Toxoplasmosis

hsa05146

Amoebiasis

hsa05152

Tuberculosis

hsa05162

Measles

hsa05164

Influenza A

hsa05168

Herpes simplex virus 1 infection

hsa05171

Coronavirus disease - COVID-19

hsa05200

Pathways in cancer

hsa05321

Inflammatory bowel disease

hsa05330

Allograft rejection

hsa05417

Lipid and atherosclerosis

Network

nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06183  Yersinia
nt06219  JAK-STAT signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06266  Non-small cell lung cancer
nt06276  Chronic myeloid leukemia
nt06517  TLR signaling
nt06518  JAK-STAT signaling

Element

N00053

Cytokine-Jak-STAT signaling pathway

N00435

TLR1/2/4-NFKB signaling pathway

N01307

SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway

N01557

IL12/23 to Jak-STAT signaling pathway

N01566

TLR5-NFKB signaling pathway

Drug target

Apilimod mesylate:

D06556

Briakinumab:

D09588

Lisofylline:

D04748

Ustekinumab:

D09214<JP/US>

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    3592 (IL12A)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3592 (IL12A)
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    3592 (IL12A)
   04622 RIG-I-like receptor signaling pathway
    3592 (IL12A)
   04625 C-type lectin receptor signaling pathway
    3592 (IL12A)
   04658 Th1 and Th2 cell differentiation
    3592 (IL12A)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3592 (IL12A)
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    3592 (IL12A)
   05164 Influenza A
    3592 (IL12A)
   05162 Measles
    3592 (IL12A)
   05168 Herpes simplex virus 1 infection
    3592 (IL12A)
  09171 Infectious disease: bacterial
   05133 Pertussis
    3592 (IL12A)
   05134 Legionellosis
    3592 (IL12A)
   05152 Tuberculosis
    3592 (IL12A)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    3592 (IL12A)
   05144 Malaria
    3592 (IL12A)
   05145 Toxoplasmosis
    3592 (IL12A)
   05140 Leishmaniasis
    3592 (IL12A)
   05142 Chagas disease
    3592 (IL12A)
   05143 African trypanosomiasis
    3592 (IL12A)
  09163 Immune disease
   05321 Inflammatory bowel disease
    3592 (IL12A)
   05330 Allograft rejection
    3592 (IL12A)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    3592 (IL12A)
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    3592 (IL12A)
   04936 Alcoholic liver disease
    3592 (IL12A)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    3592 (IL12A)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    3592 (IL12A)
Cytokines and neuropeptides [BR:hsa04052]
Cytokines
  Interleukins
   3592 (IL12A)
Glycosaminoglycan binding proteins [BR:hsa00536]
Heparan sulfate / Heparin
  Cytokines
   3592 (IL12A)

SSDB

Motif

Pfam:

IL12

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

3:159988835..159996019

AA seq 219 aa
MCPARSLLLVATLVLLDHLSLARNLPVATPDPGMFPCLHHSQNLLRAVSNMLQKARQTLE
FYPCTSEEIDHEDITKDKTSTVEACLPLELTKNESCLNSRETSFITNGSCLASRKTSFMM
ALCLSSIYEDLKMYQVEFKTMNAKLLMDPKRQIFLDQNMLAVIDELMQALNFNSETVPQK
SSLEEPDFYKTKIKLCILLHAFRIRAVTIDRVMSYLNAS

NT seq 660 nt +upstreamnt +downstreamnt
atgtgtccagcgcgcagcctcctccttgtggctaccctggtcctcctggaccacctcagt
ttggccagaaacctccccgtggccactccagacccaggaatgttcccatgccttcaccac
tcccaaaacctgctgagggccgtcagcaacatgctccagaaggccagacaaactctagaa
ttttacccttgcacttctgaagagattgatcatgaagatatcacaaaagataaaaccagc
acagtggaggcctgtttaccattggaattaaccaagaatgagagttgcctaaattccaga
gagacctctttcataactaatgggagttgcctggcctccagaaagacctcttttatgatg
gccctgtgccttagtagtatttatgaagacttgaagatgtaccaggtggagttcaagacc
atgaatgcaaagcttctgatggatcctaagaggcagatctttctagatcaaaacatgctg
gcagttattgatgagctgatgcaggccctgaatttcaacagtgagactgtgccacaaaaa
tcctcccttgaagaaccggatttttataaaactaaaatcaagctctgcatacttcttcat
gctttcagaattcgggcagtgactattgatagagtgatgagctatctgaatgcttcctaa

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