Homo sapiens (human): 10280
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Entry
10280 CDS
T01001
Symbol
SIGMAR1, ALS16, DSMA2, OPRS1, SIG-1R, SR-BP, SR-BP1, SRBP, hSigmaR1, sigma1R
Name
(RefSeq) sigma non-opioid intracellular receptor 1
KO
K20719
sigma non-opioid intracellular receptor
Organism
hsa
Homo sapiens (human)
Pathway
hsa05014
Amyotrophic lateral sclerosis
hsa05022
Pathways of neurodegeneration - multiple diseases
Network
nt06410
Calcium signaling
nt06464
Amyotrophic lateral sclerosis
Element
N01151
Mutation-inactivated SIGMAR1 to Ca2+ -apoptotic pathway
Disease
H00058
Amyotrophic lateral sclerosis (ALS)
H00856
Distal hereditary motor neuropathies
Drug target
Blarcamesine (
DG03048
):
D11383
D11549
Captodiame:
D07316
Dextromethorphan (
DG01078
):
D00848
<JP>
D03742
D03744
Fenfluramine (
DG00103
):
D04148
<JP/US>
D07945
Igmesine hydrochloride:
D04502
Opipramol (
DG00930
):
D01477
D08297
Rimcazole hydrochloride:
D02684
Tiospirone hydrochloride:
D02688
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05014 Amyotrophic lateral sclerosis
10280 (SIGMAR1)
05022 Pathways of neurodegeneration - multiple diseases
10280 (SIGMAR1)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
02000 Transporters [BR:
hsa02000
]
10280 (SIGMAR1)
Transporters [BR:
hsa02000
]
Other transporters
Accessory factors involved in transport [TC:
8
]
10280 (SIGMAR1)
BRITE hierarchy
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ERG2_Sigma1R
Motif
Other DBs
NCBI-GeneID:
10280
NCBI-ProteinID:
NP_005857
OMIM:
601978
HGNC:
8157
Ensembl:
ENSG00000147955
Pharos:
Q99720
(Tclin)
UniProt:
Q99720
Structure
PDB
LinkDB
All DBs
Position
9:complement(34634722..34637787)
Genome browser
AA seq
223 aa
AA seq
DB search
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
NT seq
672 nt
NT seq
+upstream
nt +downstream
nt
atgcagtgggccgtgggccggcggtgggcgtgggccgcgctgctcctggctgtcgcagcg
gtgctgacccaggtcgtctggctctggctgggtacgcagagcttcgtcttccagcgcgaa
gagatagcgcagttggcgcggcagtacgctgggctggaccacgagctggccttctctcgt
ctgatcgtggagctgcggcggctgcacccaggccacgtgctgcccgacgaggagctgcag
tgggtgttcgtgaatgcgggtggctggatgggcgccatgtgccttctgcacgcctcgctg
tccgagtatgtgctgctcttcggcaccgccttgggctcccgcggccactcggggcgctac
tgggctgagatctcggataccatcatctctggcaccttccaccagtggagagagggcacc
accaaaagtgaggtcttctacccaggggagacggtagtacacgggcctggtgaggcaaca
gctgtggagtgggggccaaacacatggatggtggagtacggccggggcgtcatcccatcc
accctggccttcgcgctggccgacactgtcttcagcacccaggacttcctcaccctcttc
tatactcttcgctcctatgctcggggcctccggcttgagctcaccacctacctctttggc
caggacccttga
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integrated database retrieval system
