KEGG   Homo sapiens (human): 10381
Entry
10381             CDS       T01001                                 
Symbol
TUBB3, CDCBM, CDCBM1, CFEOM3, CFEOM3A, FEOM3, TUBB4, beta-4
Name
(RefSeq) tubulin beta 3 class III
  KO
K07375  tubulin beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04540  Gap junction
hsa04814  Motor proteins
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
Network
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N00978  Anterograde axonal transport
N00979  Mutation-caused aberrant Htt to anterograde axonal transport
N01018  Mutation-caused aberrant Abeta to anterograde axonal transport
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
N01158  Mutation-caused aberrant DCTN1 to retrograde axonal transport
N01285  Microtubule-RHOA signaling pathway
N01286  Escherichia EspG to Microtubule-RHOA signaling pathway
N01295  Rab7-regulated microtubule minus-end directed transport
N01297  Arl8-regulated microtubule plus-end directed transport
N01298  Salmonella SifA to microtubule plus-end directed transport
N01299  Salmonella PipB2 to microtubule plus-end directed transport
N01403  Zn to anterograde axonal transport
N01414  Iron to anterograde axonal transport
N01535  Kinetochore microtubule attachment
N01544  Microtubule nucleation
N01547  Kinetochore fiber organization
N01549  Branching microtubule nucleation
N01553  Promotion of microtubule growth
N01561  Microtubule depolymerization
N01562  Microtubule depolymerization at the minus ends
Disease
H00838  Congenital fibrosis of the extraocular muscles
H01881  Complex cortical dysplasia with other brain malformations
Drug target
Anvatabart opadotin: D12583
Avanbulin: D11681
Batabulin (DG01412): D03059 D06560
Belantamab mafodotin: D11595<US>
Brentuximab vedotin: D09587<JP/US>
Cabazitaxel (DG00695): D09755 D10452<JP/US>
Cantuzumab mertansine: D03364
Cantuzumab ravtansine: D10454
Cevipabulin (DG01413): D06576 D08889
Colchicine: D00570<JP/US>
Denintuzumab mafodotin: D11232
Docetaxel (DG00694): D02165<JP/US> D07866<JP/US>
Enfortumab vedotin: D11525<JP/US>
Eribulin: D08914<JP/US>
Estramustine (DG00724): D02398 D04066 D06397<JP/US>
Farletuzumab ecteribulin: D12183
Glembatumumab vedotin: D09912
Indibulin: D10013
Ixabepilone: D04645<US>
Lexibulin: D10073
Lifastuzumab vedotin: D11238
Lisavanbulin: D11494
Lorvotuzumab mertansine: D09927
Maytansine: D04864
Mecbotamab vedotin: D12220
Mirvetuximab soravtansine: D10954<US>
Mivobulin isethionate: D05062
Oberotatug ravtansine: D12916
Opadotin: D12582
Ozuriftmab vedotin: D12210
Paclitaxel: D00491<JP/US>
Paclitaxel poliglumex: D05333
Sabizabulin (DG03253): D12519 D12520
Soblidotin: D01919
Soravtansine: D11228
Taltobulin: D06001
Tasidotin hydrochloride: D06009
Tirbanibulin (DG03082): D11691<US> D11692
Tisotumab vedotin: D11814<US>
Trastuzumab emtansine: D09980<JP/US>
Tusamitamab ravtansine: D12310
Vedotin: D09691
Verubulin (DG01411): D10029 D10030
Vinblastine (DG00689): D01068<JP/US> D08675
Vincristine (DG00690): D02197<JP/US> D08679
Vindesine (DG00691): D01769<JP> D06304
Vinepidine sulfate: D06305
Vinflunine: D09032
Vinglycinate sulfate: D06306
Vinleurosine sulfate: D06307
Vinorelbine (DG00692): D01935<JP/US> D08680
Vinrosidine sulfate: D06308
Vinzolidine sulfate: D06309
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    10381 (TUBB3)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    10381 (TUBB3)
  09142 Cell motility
   04814 Motor proteins
    10381 (TUBB3)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    10381 (TUBB3)
   05132 Salmonella infection
    10381 (TUBB3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    10381 (TUBB3)
   05012 Parkinson disease
    10381 (TUBB3)
   05014 Amyotrophic lateral sclerosis
    10381 (TUBB3)
   05016 Huntington disease
    10381 (TUBB3)
   05020 Prion disease
    10381 (TUBB3)
   05022 Pathways of neurodegeneration - multiple diseases
    10381 (TUBB3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    10381 (TUBB3)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    10381 (TUBB3)
   04147 Exosome [BR:hsa04147]
    10381 (TUBB3)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Microtubules and associated factors
    Other tubulins
     10381 (TUBB3)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    10381 (TUBB3)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   10381 (TUBB3)
  Exosomal proteins of colorectal cancer cells
   10381 (TUBB3)
  Exosomal proteins of bladder cancer cells
   10381 (TUBB3)
SSDB
Motif
Pfam: Tubulin Tubulin_C Misat_Tub_SegII Tubulin_3 Tubulin_2
Other DBs
NCBI-GeneID: 10381
NCBI-ProteinID: NP_006077
OMIM: 602661
HGNC: 20772
Ensembl: ENSG00000258947
UniProt: Q13509 Q53G92
Structure
LinkDB
Position
16:89921925..89936097
AA seq 450 aa
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGNYVGDSDLQLERISVYYNEASSHKYV
PRAILVDLEPGTMDSVRSGAFGHLFRPDNFIFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKECENCDCLQGFQLTHSLGGGTGSGMGTLLISKVREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSIHQLVENTDETYCIDNEALYDICFRTLKLATPTYGDLNHLVSATMSGVTTSL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVATVFRGRMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRG
LKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEGEMYEDDEEESEAQGPK
NT seq 1353 nt   +upstreamnt  +downstreamnt
atgagggagatcgtgcacatccaggccggccagtgcggcaaccagatcggggccaagttc
tgggaagtcatcagtgatgagcatggcatcgaccccagcggcaactacgtgggcgactcg
gacttgcagctggagcggatcagcgtctactacaacgaggcctcttctcacaagtacgtg
cctcgagccattctggtggacctggaacccggaaccatggacagtgtccgctcaggggcc
tttggacatctcttcaggcctgacaatttcatctttggtcagagtggggccggcaacaac
tgggccaagggtcactacacggagggggcggagctggtggattcggtcctggatgtggtg
cggaaggagtgtgaaaactgcgactgcctgcagggcttccagctgacccactcgctgggg
ggcggcacgggctccggcatgggcacgttgctcatcagcaaggtgcgtgaggagtatccc
gaccgcatcatgaacaccttcagcgtcgtgccctcacccaaggtgtcagacacggtggtg
gagccctacaacgccacgctgtccatccaccagctggtggagaacacggatgagacctac
tgcatcgacaacgaggcgctctacgacatctgcttccgcaccctcaagctggccacgccc
acctacggggacctcaaccacctggtatcggccaccatgagcggagtcaccacctccttg
cgcttcccgggccagctcaacgctgacctgcgcaagctggccgtcaacatggtgcccttc
ccgcgcctgcacttcttcatgcccggcttcgcccccctcacagcccggggcagccagcag
taccgggccctgaccgtgcccgagctcacccagcagatgttcgatgccaagaacatgatg
gccgcctgcgacccgcgccacggccgctacctgacggtggccaccgtgttccggggccgc
atgtccatgaaggaggtggacgagcagatgctggccatccagagcaagaacagcagctac
ttcgtggagtggatccccaacaacgtgaaggtggccgtgtgtgacatcccgccccgcggc
ctcaagatgtcctccaccttcatcgggaacagcacggccatccaggagctgttcaagcgc
atctccgagcagttcacggccatgttccggcgcaaggccttcctgcactggtacacgggc
gagggcatggacgagatggagttcaccgaggccgagagcaacatgaacgacctggtgtcc
gagtaccagcagtaccaggacgccacggccgaggaagagggcgagatgtacgaagacgac
gaggaggagtcggaggcccagggccccaagtga

KEGG   Homo sapiens (human): 10382
Entry
10382             CDS       T01001                                 
Symbol
TUBB4A, DYT4, TUBB4, beta-5
Name
(RefSeq) tubulin beta 4A class IVa
  KO
K07375  tubulin beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04540  Gap junction
hsa04814  Motor proteins
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
Network
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N00978  Anterograde axonal transport
N00979  Mutation-caused aberrant Htt to anterograde axonal transport
N01018  Mutation-caused aberrant Abeta to anterograde axonal transport
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
N01158  Mutation-caused aberrant DCTN1 to retrograde axonal transport
N01285  Microtubule-RHOA signaling pathway
N01286  Escherichia EspG to Microtubule-RHOA signaling pathway
N01295  Rab7-regulated microtubule minus-end directed transport
N01297  Arl8-regulated microtubule plus-end directed transport
N01298  Salmonella SifA to microtubule plus-end directed transport
N01299  Salmonella PipB2 to microtubule plus-end directed transport
N01403  Zn to anterograde axonal transport
N01414  Iron to anterograde axonal transport
N01535  Kinetochore microtubule attachment
N01544  Microtubule nucleation
N01547  Kinetochore fiber organization
N01549  Branching microtubule nucleation
N01553  Promotion of microtubule growth
N01561  Microtubule depolymerization
N01562  Microtubule depolymerization at the minus ends
Disease
H00679  Hypomyelinating leukodystrophy
H00831  Primary dystonia
Drug target
Anvatabart opadotin: D12583
Avanbulin: D11681
Batabulin (DG01412): D03059 D06560
Belantamab mafodotin: D11595<US>
Brentuximab vedotin: D09587<JP/US>
Cabazitaxel (DG00695): D09755 D10452<JP/US>
Cantuzumab mertansine: D03364
Cantuzumab ravtansine: D10454
Cevipabulin (DG01413): D06576 D08889
Colchicine: D00570<JP/US>
Denintuzumab mafodotin: D11232
Docetaxel (DG00694): D02165<JP/US> D07866<JP/US>
Enfortumab vedotin: D11525<JP/US>
Eribulin: D08914<JP/US>
Estramustine (DG00724): D02398 D04066 D06397<JP/US>
Farletuzumab ecteribulin: D12183
Glembatumumab vedotin: D09912
Indibulin: D10013
Ixabepilone: D04645<US>
Lexibulin: D10073
Lifastuzumab vedotin: D11238
Lisavanbulin: D11494
Lorvotuzumab mertansine: D09927
Maytansine: D04864
Mecbotamab vedotin: D12220
Mirvetuximab soravtansine: D10954<US>
Mivobulin isethionate: D05062
Oberotatug ravtansine: D12916
Opadotin: D12582
Ozuriftmab vedotin: D12210
Paclitaxel: D00491<JP/US>
Paclitaxel poliglumex: D05333
Sabizabulin (DG03253): D12519 D12520
Soblidotin: D01919
Soravtansine: D11228
Taltobulin: D06001
Tasidotin hydrochloride: D06009
Tirbanibulin (DG03082): D11691<US> D11692
Tisotumab vedotin: D11814<US>
Trastuzumab emtansine: D09980<JP/US>
Tusamitamab ravtansine: D12310
Vedotin: D09691
Verubulin (DG01411): D10029 D10030
Vinblastine (DG00689): D01068<JP/US> D08675
Vincristine (DG00690): D02197<JP/US> D08679
Vindesine (DG00691): D01769<JP> D06304
Vinepidine sulfate: D06305
Vinflunine: D09032
Vinglycinate sulfate: D06306
Vinleurosine sulfate: D06307
Vinorelbine (DG00692): D01935<JP/US> D08680
Vinrosidine sulfate: D06308
Vinzolidine sulfate: D06309
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    10382 (TUBB4A)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    10382 (TUBB4A)
  09142 Cell motility
   04814 Motor proteins
    10382 (TUBB4A)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    10382 (TUBB4A)
   05132 Salmonella infection
    10382 (TUBB4A)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    10382 (TUBB4A)
   05012 Parkinson disease
    10382 (TUBB4A)
   05014 Amyotrophic lateral sclerosis
    10382 (TUBB4A)
   05016 Huntington disease
    10382 (TUBB4A)
   05020 Prion disease
    10382 (TUBB4A)
   05022 Pathways of neurodegeneration - multiple diseases
    10382 (TUBB4A)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    10382 (TUBB4A)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    10382 (TUBB4A)
   04147 Exosome [BR:hsa04147]
    10382 (TUBB4A)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Microtubules and associated factors
    Other tubulins
     10382 (TUBB4A)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    10382 (TUBB4A)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   10382 (TUBB4A)
  Exosomal proteins of colorectal cancer cells
   10382 (TUBB4A)
  Exosomal proteins of bladder cancer cells
   10382 (TUBB4A)
SSDB
Motif
Pfam: Tubulin Tubulin_C Misat_Tub_SegII Tubulin_3 Tubulin_2
Other DBs
NCBI-GeneID: 10382
NCBI-ProteinID: NP_001276058
OMIM: 602662
HGNC: 20774
Ensembl: ENSG00000104833
UniProt: P04350
LinkDB
Position
19:complement(6494319..6502848)
AA seq 444 aa
MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGNYV
PRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDAVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLSVQSKNSSYFVEWIPNNVKTAVCDIPPRG
LKMAATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEGEFEEEAEEEVA
NT seq 1335 nt   +upstreamnt  +downstreamnt
atgcgggagatcgtgcacctgcaggccggccagtgcggcaaccagatcggggccaagttt
tgggaggttatcagtgacgaacatggcatcgaccccacaggcacataccatggggacagt
gacctgcaactggagaggatcaacgtgtactacaacgaggccacaggaggaaattatgtc
cccagagcggtgctggtggacctggaacccggcaccatggactctgtccgttctggcccc
ttcggtcagatctttcggccggacaacttcgtgtttggccaatccggagccggcaacaac
tgggcaaaggggcactacacggagggcgcagagctggtggacgctgtcctggacgtagtc
cggaaggaggccgagagctgcgactgccttcagggcttccagctgacccactcgctgggg
ggtggcacggggtccggaatgggcacgctgctcatcagtaagatccgcgaggagttccca
gaccgcatcatgaacaccttcagcgtggtgccctcgcccaaagtgtcagacacggtggtg
gagccctacaacgccacgctgtctgtgcaccagctggtggagaatacggatgagacctac
tgcatcgacaacgaggcactctacgacatctgtttccgcaccctcaagctgaccaccccc
acctacggggacctcaaccacctggtgtcggccaccatgagcggggtcaccacctgcctg
cgcttcccgggccagctgaacgccgacctgcgcaagctggccgtcaacatggttcccttt
cctcgcctgcacttcttcatgcccggcttcgcacccctgaccagccggggcagccagcag
taccgggccctgacggtgcccgagctcacccagcagatgttcgatgccaagaacatgatg
gcggcgtgcgacccgcgccacggccgctacctgaccgtggccgccgtgttccggggccgc
atgtccatgaaggaggtggacgagcagatgctgagcgtgcagagcaagaacagcagctac
ttcgtggagtggatccccaacaacgtgaagacggccgtgtgcgacatcccgccccgcggc
ctgaagatggccgcgaccttcatcggcaacagcacggccatccaggagctgttcaagcgc
atctccgagcagttcacggccatgttccggcgcaaggccttcttgcactggtacacgggc
gagggcatggacgagatggagttcaccgaggccgagagcaacatgaatgacctggtatct
gagtaccagcagtaccaggacgccacggccgaggagggcgagttcgaggaggaggcggag
gaggaggtggcctag

KEGG   Homo sapiens (human): 10383
Entry
10383             CDS       T01001                                 
Symbol
TUBB4B, Beta2, LCAEOD, TUBB2, TUBB2C
Name
(RefSeq) tubulin beta 4B class IVb
  KO
K07375  tubulin beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04540  Gap junction
hsa04814  Motor proteins
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
Network
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N00978  Anterograde axonal transport
N00979  Mutation-caused aberrant Htt to anterograde axonal transport
N01018  Mutation-caused aberrant Abeta to anterograde axonal transport
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
N01158  Mutation-caused aberrant DCTN1 to retrograde axonal transport
N01285  Microtubule-RHOA signaling pathway
N01286  Escherichia EspG to Microtubule-RHOA signaling pathway
N01295  Rab7-regulated microtubule minus-end directed transport
N01297  Arl8-regulated microtubule plus-end directed transport
N01298  Salmonella SifA to microtubule plus-end directed transport
N01299  Salmonella PipB2 to microtubule plus-end directed transport
N01403  Zn to anterograde axonal transport
N01414  Iron to anterograde axonal transport
N01535  Kinetochore microtubule attachment
N01544  Microtubule nucleation
N01547  Kinetochore fiber organization
N01549  Branching microtubule nucleation
N01553  Promotion of microtubule growth
N01561  Microtubule depolymerization
N01562  Microtubule depolymerization at the minus ends
Disease
H00837  Leber congenital amaurosis
Drug target
Anvatabart opadotin: D12583
Avanbulin: D11681
Batabulin (DG01412): D03059 D06560
Belantamab mafodotin: D11595<US>
Brentuximab vedotin: D09587<JP/US>
Cabazitaxel (DG00695): D09755 D10452<JP/US>
Cantuzumab mertansine: D03364
Cantuzumab ravtansine: D10454
Cevipabulin (DG01413): D06576 D08889
Colchicine: D00570<JP/US>
Denintuzumab mafodotin: D11232
Docetaxel (DG00694): D02165<JP/US> D07866<JP/US>
Enfortumab vedotin: D11525<JP/US>
Eribulin: D08914<JP/US>
Estramustine (DG00724): D02398 D04066 D06397<JP/US>
Farletuzumab ecteribulin: D12183
Glembatumumab vedotin: D09912
Indibulin: D10013
Ixabepilone: D04645<US>
Lexibulin: D10073
Lifastuzumab vedotin: D11238
Lisavanbulin: D11494
Lorvotuzumab mertansine: D09927
Maytansine: D04864
Mecbotamab vedotin: D12220
Mirvetuximab soravtansine: D10954<US>
Mivobulin isethionate: D05062
Oberotatug ravtansine: D12916
Opadotin: D12582
Ozuriftmab vedotin: D12210
Paclitaxel: D00491<JP/US>
Paclitaxel poliglumex: D05333
Sabizabulin (DG03253): D12519 D12520
Soblidotin: D01919
Soravtansine: D11228
Taltobulin: D06001
Tasidotin hydrochloride: D06009
Tirbanibulin (DG03082): D11691<US> D11692
Tisotumab vedotin: D11814<US>
Trastuzumab emtansine: D09980<JP/US>
Tusamitamab ravtansine: D12310
Vedotin: D09691
Verubulin (DG01411): D10029 D10030
Vinblastine (DG00689): D01068<JP/US> D08675
Vincristine (DG00690): D02197<JP/US> D08679
Vindesine (DG00691): D01769<JP> D06304
Vinepidine sulfate: D06305
Vinflunine: D09032
Vinglycinate sulfate: D06306
Vinleurosine sulfate: D06307
Vinorelbine (DG00692): D01935<JP/US> D08680
Vinrosidine sulfate: D06308
Vinzolidine sulfate: D06309
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    10383 (TUBB4B)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    10383 (TUBB4B)
  09142 Cell motility
   04814 Motor proteins
    10383 (TUBB4B)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    10383 (TUBB4B)
   05132 Salmonella infection
    10383 (TUBB4B)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    10383 (TUBB4B)
   05012 Parkinson disease
    10383 (TUBB4B)
   05014 Amyotrophic lateral sclerosis
    10383 (TUBB4B)
   05016 Huntington disease
    10383 (TUBB4B)
   05020 Prion disease
    10383 (TUBB4B)
   05022 Pathways of neurodegeneration - multiple diseases
    10383 (TUBB4B)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    10383 (TUBB4B)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    10383 (TUBB4B)
   04147 Exosome [BR:hsa04147]
    10383 (TUBB4B)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Microtubules and associated factors
    Other tubulins
     10383 (TUBB4B)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    10383 (TUBB4B)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   10383 (TUBB4B)
  Exosomal proteins of colorectal cancer cells
   10383 (TUBB4B)
  Exosomal proteins of bladder cancer cells
   10383 (TUBB4B)
SSDB
Motif
Pfam: Tubulin Tubulin_C Misat_Tub_SegII Tubulin_3 Tubulin_2
Other DBs
NCBI-GeneID: 10383
NCBI-ProteinID: NP_006079
OMIM: 602660
HGNC: 20771
Ensembl: ENSG00000188229
UniProt: P68371
Structure
LinkDB
Position
9:137241287..137243707
AA seq 445 aa
MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYV
PRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEGEFEEEAEEEVA
NT seq 1338 nt   +upstreamnt  +downstreamnt
atgagggaaatcgtgcacttgcaggccgggcagtgcggcaaccaaatcggcgccaagttt
tgggaggtgatcagcgatgagcacggcatcgaccccacgggcacctaccacggggacagc
gacctgcagctggaacgcatcaacgtgtactacaatgaggccaccggcggcaagtacgtg
ccccgcgccgtgctcgtggatctggagcccggcaccatggactccgtgcgctcggggccc
ttcgggcagatcttccggccggacaacttcgttttcggtcagagtggtgctgggaacaac
tgggccaaggggcactacacagaaggcgcggagctggtggactcggtgctggatgttgtg
agaaaggaggctgagagctgtgactgcctgcagggtttccagctgacccactccctgggt
ggggggactgggtctgggatgggtaccctcctcatcagcaagatccgggaggagtaccca
gacaggatcatgaacacgtttagtgtggtgccttcgcccaaagtgtcagacacagtggtg
gagccctacaacgccaccctctcagtccaccagctcgtagaaaacacagacgagacctac
tgcattgataacgaagctctctacgacatttgcttcagaaccctaaagctgaccacgccc
acctatggtgacctgaaccacctggtgtctgctaccatgagtggggtcaccacctgcctg
cgcttcccaggccagctcaatgctgacctgcggaagctggctgtgaacatggtcccgttt
ccccggctgcacttcttcatgcccggctttgccccactgaccagccggggcagccagcag
taccgggcgctgaccgtgcccgagctcacccagcagatgtttgatgccaagaacatgatg
gctgcctgcgacccccgccatggccgctacctgacggttgccgccgtgttcaggggccgc
atgtccatgaaggaggtggatgagcaaatgcttaatgtccaaaacaaaaacagcagctat
tttgttgagtggatccccaacaatgtgaaaacggctgtctgtgacatcccacctcggggg
ctaaaaatgtccgccaccttcattggcaacagcacggccatccaggagctgttcaagcgc
atctccgagcagttcacggccatgttccggcgcaaggccttcctgcactggtacacgggc
gagggcatggacgagatggagttcaccgaggccgagagcaacatgaatgacctggtgtcc
gagtaccagcagtaccaggatgccacagccgaggaggagggcgagttcgaggaggaggct
gaggaggaggtggcctag

KEGG   Homo sapiens (human): 124908013
Entry
124908013         CDS       T01001                                 
Name
(RefSeq) tubulin beta 8B
  KO
K07375  tubulin beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04540  Gap junction
hsa04814  Motor proteins
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    124908013
  09144 Cellular community - eukaryotes
   04540 Gap junction
    124908013
  09142 Cell motility
   04814 Motor proteins
    124908013
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    124908013
   05132 Salmonella infection
    124908013
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    124908013
   05012 Parkinson disease
    124908013
   05014 Amyotrophic lateral sclerosis
    124908013
   05016 Huntington disease
    124908013
   05020 Prion disease
    124908013
   05022 Pathways of neurodegeneration - multiple diseases
    124908013
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    124908013
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    124908013
   04147 Exosome [BR:hsa04147]
    124908013
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Microtubules and associated factors
    Other tubulins
     124908013
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    124908013
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   124908013
  Exosomal proteins of colorectal cancer cells
   124908013
  Exosomal proteins of bladder cancer cells
   124908013
SSDB
Motif
Pfam: Tubulin Tubulin_C Misat_Tub_SegII Tubulin_3 Tubulin_2
Other DBs
NCBI-GeneID: 124908013
NCBI-ProteinID: NP_001408673
LinkDB
Position
18
AA seq 444 aa
MREIVLTQTGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVHHHEASGGRYV
PRAVLVDLEPGTMDSVHSGPFGQVFRPDNFISGQCGAGNNWAKGRYTEGAELTESVMDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIINTFSILPSPKVSDTVV
EPYNATLSVHQLIENADETFCIDNEALYDICSRTLKLPTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMM
AACDPRHGCYLTVAAIFRGRMPMREVDEQMFNIQDKNSSYFADWFPDNVKTAVCDIPPRG
LKMSATFIGNNAAIQELFTCVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEEDEEYAEEEVA
NT seq 1335 nt   +upstreamnt  +downstreamnt
atgagggaaatcgtgctcacgcagaccgggcagtgcgggaaccagatcggcgccaagttc
tgggaggtgatctctgatgaacatgccatcgactccgctggcacctaccacggggacagc
cacctgcagctggagcgcatcaacgtgcaccaccacgaggccagcggtggcaggtacgtg
ccccgcgctgtgctcgtggatctggagccgggcaccatggactctgtgcactcggggccc
ttcgggcaggtcttcaggccagacaacttcatttccggtcagtgtggggccggaaacaac
tgggccaagggacgctacacagaaggcgcggagctgacggagtcagtgatggacgttgtc
agaaaggaggctgagagctgtgactgcctgcagggtttccagctgacccactccctgggt
ggggggactgggtctgggatgggtacccttctcattagtaagatccgggaggagtaccca
gacaggatcataaacacattcagcatcctgccctcgcccaaggtgtcggacaccgtggtg
gagccctacaacgccaccctctcagtccaccagctcatagaaaacgcggatgagaccttc
tgcatagataacgaagcgctatatgacatatgttccaggaccctaaaactgcccacaccc
acctatggtgacctgaaccacctggtgtctgctaccatgagtggggtcaccacatgcctg
cgcttcccaggccagctgaatgctgacctgcggaagctggccgtgaacatggtcccgttt
ccccggctgcatttcttcatgcccggctttgccccactgaccagccggggcagccagcag
taccgggccttgactgtggctgagctcacccagcagatgtttgatgctaagaacatgatg
gctgcctgtgacccccgtcacggctgctacctaacggtggctgccattttcaggggtcgc
atgcccatgagggaggtggatgaacaaatgttcaacattcaagataagaacagcagctac
tttgctgactggttccccgacaacgtaaaaacagccgtctgtgacatcccaccccggggg
ctaaaaatgtcagccaccttcattgggaataatgcggccatccaggaactcttcacatgt
gtctcagagcagtttacagcaatgttcaggcgcaaggccttcctccactggtacacgggc
gagggcatggatgagatggaattcaccgaggccgagagcaacatgaacgacctggtgtct
gaatatcagcaatatcaggatgccacggccgaggaggaggaggatgaggagtatgccgag
gaggaggtggcctag

KEGG   Homo sapiens (human): 124908015
Entry
124908015         CDS       T01001                                 
Name
(RefSeq) tubulin beta 8B
  KO
K07375  tubulin beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04540  Gap junction
hsa04814  Motor proteins
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    124908015
  09144 Cellular community - eukaryotes
   04540 Gap junction
    124908015
  09142 Cell motility
   04814 Motor proteins
    124908015
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    124908015
   05132 Salmonella infection
    124908015
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    124908015
   05012 Parkinson disease
    124908015
   05014 Amyotrophic lateral sclerosis
    124908015
   05016 Huntington disease
    124908015
   05020 Prion disease
    124908015
   05022 Pathways of neurodegeneration - multiple diseases
    124908015
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    124908015
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    124908015
   04147 Exosome [BR:hsa04147]
    124908015
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Microtubules and associated factors
    Other tubulins
     124908015
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    124908015
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   124908015
  Exosomal proteins of colorectal cancer cells
   124908015
  Exosomal proteins of bladder cancer cells
   124908015
SSDB
Motif
Pfam: Tubulin Tubulin_C Misat_Tub_SegII Tubulin_3 Tubulin_2
Other DBs
NCBI-GeneID: 124908015
NCBI-ProteinID: NP_001408671
LinkDB
Position
18
AA seq 444 aa
MREIVLTQTGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVHHHEASGGRYV
PRAVLVDLEPGTMDSVHSGPFGQVFRPDNFISGQCGAGNNWAKGRYTEGAELTESVMDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIINTFSILPSPKVSDTVV
EPYNATLSVHQLIENADETFCIDNEALYDICSRTLKLPTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMM
AACDPRHGCYLTVAAIFRGRMPMREVDEQMFNIQDKNSSYFADWFPDNVKTAVCDIPPRG
LKMSATFIGNNAAIQELFTCVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEEDEEYAEEEVA
NT seq 1335 nt   +upstreamnt  +downstreamnt
atgagggaaatcgtgctcacgcagaccgggcagtgcgggaaccagatcggcgccaagttc
tgggaggtgatctctgatgaacatgccatcgactccgctggcacctaccacggggacagc
cacctgcagctggagcgcatcaacgtgcaccaccacgaggccagcggtggcaggtacgtg
ccccgcgctgtgctcgtggatctggagccgggcaccatggactctgtgcactcggggccc
ttcgggcaggtcttcaggccagacaacttcatttccggtcagtgtggggccggaaacaac
tgggccaagggacgctacacagaaggcgcggagctgacggagtcagtgatggacgttgtc
agaaaggaggctgagagctgtgactgcctgcagggtttccagctgacccactccctgggt
ggggggactgggtctgggatgggtacccttctcattagtaagatccgggaggagtaccca
gacaggatcataaacacattcagcatcctgccctcgcccaaggtgtcggacaccgtggtg
gagccctacaacgccaccctctcagtccaccagctcatagaaaacgcggatgagaccttc
tgcatagataacgaagcgctatatgacatatgttccaggaccctaaaactgcccacaccc
acctatggtgacctgaaccacctggtgtctgctaccatgagtggggtcaccacatgcctg
cgcttcccaggccagctgaatgctgacctgcggaagctggccgtgaacatggtcccgttt
ccccggctgcatttcttcatgcccggctttgccccactgaccagccggggcagccagcag
taccgggccttgactgtggctgagctcacccagcagatgtttgatgctaagaacatgatg
gctgcctgtgacccccgtcacggctgctacctaacggtggctgccattttcaggggtcgc
atgcccatgagggaggtggatgaacaaatgttcaacattcaagataagaacagcagctac
tttgctgactggttccccgacaacgtaaaaacagccgtctgtgacatcccaccccggggg
ctaaaaatgtcagccaccttcattgggaataatgcggccatccaggaactcttcacatgt
gtctcagagcagtttacagcaatgttcaggcgcaaggccttcctccactggtacacgggc
gagggcatggatgagatggaattcaccgaggccgagagcaacatgaacgacctggtgtct
gaatatcagcaatatcaggatgccacggccgaggaggaggaggatgaggagtatgccgag
gaggaggtggcctag

KEGG   Homo sapiens (human): 124908041
Entry
124908041         CDS       T01001                                 
Name
(RefSeq) tubulin beta 8B
  KO
K07375  tubulin beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04540  Gap junction
hsa04814  Motor proteins
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    124908041
  09144 Cellular community - eukaryotes
   04540 Gap junction
    124908041
  09142 Cell motility
   04814 Motor proteins
    124908041
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    124908041
   05132 Salmonella infection
    124908041
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    124908041
   05012 Parkinson disease
    124908041
   05014 Amyotrophic lateral sclerosis
    124908041
   05016 Huntington disease
    124908041
   05020 Prion disease
    124908041
   05022 Pathways of neurodegeneration - multiple diseases
    124908041
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    124908041
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    124908041
   04147 Exosome [BR:hsa04147]
    124908041
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Microtubules and associated factors
    Other tubulins
     124908041
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    124908041
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   124908041
  Exosomal proteins of colorectal cancer cells
   124908041
  Exosomal proteins of bladder cancer cells
   124908041
SSDB
Motif
Pfam: Tubulin Tubulin_C Misat_Tub_SegII Tubulin_3 Tubulin_2
Other DBs
NCBI-GeneID: 124908041
NCBI-ProteinID: NP_001408659
LinkDB
Position
18
AA seq 444 aa
MREIVLTQTGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVHHHEASGGRYV
PRAVLVDLEPGTMDSVHSGPFGQVFRPDNFISGQCGAGNNWAKGRYTEGAELTESVMDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIINTFSILPSPKVSDTVV
EPYNATLSVHQLIENADETFCIDNEALYDICSRTLKLPTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMM
AACDPRHGCYLTVAAIFRGRMPMREVDEQMFNIQDKNSSYFADWFPDNVKTAVCDIPPRG
LKMSATFIGNNAAIQELFTCVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEEDEEYAEEEVA
NT seq 1335 nt   +upstreamnt  +downstreamnt
atgagggaaatcgtgctcacgcagaccgggcagtgcgggaaccagatcggcgccaagttc
tgggaggtaatctctgatgaacatgccatcgactccgctggcacctaccacggggacagc
cacctgcagctggagcgcatcaacgtgcaccaccacgaggccagcggtggcaggtacgtg
ccccgcgctgtgctcgtggatctggagccgggcaccatggactctgtgcactcggggccc
ttcgggcaggtcttcaggccagacaacttcatttccggtcagtgtggggccggaaacaac
tgggccaagggacgctacacagaaggcgcggagctgacggagtcagtgatggacgttgtc
agaaaggaggctgagagctgtgactgcctgcagggtttccagctgacccactccctgggt
ggggggactgggtctgggatgggtacccttctcattagtaagatccgggaggagtaccca
gacaggatcataaacacattcagcatcctgccctcgcccaaggtgtcggacaccgtggtg
gagccctacaacgccaccctctcagtccaccagctcatagaaaacgcggatgagaccttc
tgcatagataacgaagcgctatatgacatatgttccaggaccctaaaactgcccacaccc
acctatggtgacctgaaccacctggtgtctgctaccatgagtggggtcaccacatgcctg
cgcttcccaggccagctgaatgctgacctgcggaagctggccgtgaacatggtcccgttt
ccccggctgcatttcttcatgcccggctttgccccactgaccagccggggcagccagcag
taccgggccttgactgtggctgagctcacccagcagatgtttgatgctaagaacatgatg
gctgcctgtgacccccgtcacggctgctacctaacggtggctgccattttcaggggtcgc
atgcccatgagggaggtggatgaacaaatgttcaacattcaagataagaacagcagctac
tttgctgactggttccccgacaacgtaaaaacagccgtctgtgacatcccaccccggggg
ctaaaaatgtcagccaccttcattgggaataatgcggccatccaggaactcttcacatgt
gtctcagagcagtttacagcaatgttcaggcgcaaggccttcctccactggtacacgggc
gagggcatggatgagatggaattcaccgaggccgagagcaacatgaacgacctggtgtct
gaatatcagcaatatcaggatgccacggccgaggaggaggaggatgaggagtatgccgag
gaggaggtggcctag

KEGG   Homo sapiens (human): 203068
Entry
203068            CDS       T01001                                 
Symbol
TUBB, CDCBM6, CSCSC1, M40, OK/SW-cl.56, TUBB1, TUBB5
Name
(RefSeq) tubulin beta class I
  KO
K07375  tubulin beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04540  Gap junction
hsa04814  Motor proteins
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
Network
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N00978  Anterograde axonal transport
N00979  Mutation-caused aberrant Htt to anterograde axonal transport
N01018  Mutation-caused aberrant Abeta to anterograde axonal transport
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
N01158  Mutation-caused aberrant DCTN1 to retrograde axonal transport
N01285  Microtubule-RHOA signaling pathway
N01286  Escherichia EspG to Microtubule-RHOA signaling pathway
N01295  Rab7-regulated microtubule minus-end directed transport
N01297  Arl8-regulated microtubule plus-end directed transport
N01298  Salmonella SifA to microtubule plus-end directed transport
N01299  Salmonella PipB2 to microtubule plus-end directed transport
N01403  Zn to anterograde axonal transport
N01414  Iron to anterograde axonal transport
N01535  Kinetochore microtubule attachment
N01544  Microtubule nucleation
N01547  Kinetochore fiber organization
N01549  Branching microtubule nucleation
N01553  Promotion of microtubule growth
N01561  Microtubule depolymerization
N01562  Microtubule depolymerization at the minus ends
Disease
H01579  Congenital symmetric circumferential skin creases
H01881  Complex cortical dysplasia with other brain malformations
Drug target
Anvatabart opadotin: D12583
Avanbulin: D11681
Batabulin (DG01412): D03059 D06560
Belantamab mafodotin: D11595<US>
Brentuximab vedotin: D09587<JP/US>
Cabazitaxel (DG00695): D09755 D10452<JP/US>
Cantuzumab mertansine: D03364
Cantuzumab ravtansine: D10454
Cevipabulin (DG01413): D06576 D08889
Colchicine: D00570<JP/US>
Denintuzumab mafodotin: D11232
Docetaxel (DG00694): D02165<JP/US> D07866<JP/US>
Enfortumab vedotin: D11525<JP/US>
Eribulin: D08914<JP/US>
Estramustine (DG00724): D02398 D04066 D06397<JP/US>
Farletuzumab ecteribulin: D12183
Glembatumumab vedotin: D09912
Indibulin: D10013
Ixabepilone: D04645<US>
Lexibulin: D10073
Lifastuzumab vedotin: D11238
Lisavanbulin: D11494
Lorvotuzumab mertansine: D09927
Maytansine: D04864
Mecbotamab vedotin: D12220
Mirvetuximab soravtansine: D10954<US>
Mivobulin isethionate: D05062
Oberotatug ravtansine: D12916
Opadotin: D12582
Ozuriftmab vedotin: D12210
Paclitaxel: D00491<JP/US>
Paclitaxel poliglumex: D05333
Sabizabulin (DG03253): D12519 D12520
Soblidotin: D01919
Soravtansine: D11228
Taltobulin: D06001
Tasidotin hydrochloride: D06009
Tirbanibulin (DG03082): D11691<US> D11692
Tisotumab vedotin: D11814<US>
Trastuzumab emtansine: D09980<JP/US>
Tusamitamab ravtansine: D12310
Vedotin: D09691
Verubulin (DG01411): D10029 D10030
Vinblastine (DG00689): D01068<JP/US> D08675
Vincristine (DG00690): D02197<JP/US> D08679
Vindesine (DG00691): D01769<JP> D06304
Vinepidine sulfate: D06305
Vinflunine: D09032
Vinglycinate sulfate: D06306
Vinleurosine sulfate: D06307
Vinorelbine (DG00692): D01935<JP/US> D08680
Vinrosidine sulfate: D06308
Vinzolidine sulfate: D06309
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    203068 (TUBB)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    203068 (TUBB)
  09142 Cell motility
   04814 Motor proteins
    203068 (TUBB)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    203068 (TUBB)
   05132 Salmonella infection
    203068 (TUBB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    203068 (TUBB)
   05012 Parkinson disease
    203068 (TUBB)
   05014 Amyotrophic lateral sclerosis
    203068 (TUBB)
   05016 Huntington disease
    203068 (TUBB)
   05020 Prion disease
    203068 (TUBB)
   05022 Pathways of neurodegeneration - multiple diseases
    203068 (TUBB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    203068 (TUBB)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    203068 (TUBB)
   04147 Exosome [BR:hsa04147]
    203068 (TUBB)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Microtubules and associated factors
    Other tubulins
     203068 (TUBB)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    203068 (TUBB)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   203068 (TUBB)
  Exosomal proteins of colorectal cancer cells
   203068 (TUBB)
  Exosomal proteins of bladder cancer cells
   203068 (TUBB)
SSDB
Motif
Pfam: Tubulin Tubulin_C Misat_Tub_SegII Tubulin_3 Tubulin_2
Other DBs
NCBI-GeneID: 203068
NCBI-ProteinID: NP_821133
OMIM: 191130
HGNC: 20778
Ensembl: ENSG00000196230
UniProt: P07437 Q5SU16
Structure
LinkDB
Position
6:30720352..30725422
AA seq 444 aa
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLDRISVYYNEATGGKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQVFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMAVTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEEDFGEEAEEEA
NT seq 1335 nt   +upstreamnt  +downstreamnt
atgagggaaatcgtgcacatccaggctggtcagtgtggcaaccagatcggtgccaagttc
tgggaggtgatcagtgatgaacatggcatcgaccccaccggcacctaccacggggacagc
gacctgcagctggaccgcatctctgtgtactacaatgaagccacaggtggcaaatatgtt
cctcgtgccatcctggtggatctagaacctgggaccatggactctgttcgctcaggtcct
tttggccagatctttagaccagacaactttgtatttggtcagtctggggcaggtaacaac
tgggccaaaggccactacacagagggcgccgagctggttgattctgtcctggatgtggta
cggaaggaggcagagagctgtgactgcctgcagggcttccagctgacccactcactgggc
gggggcacaggctctggaatgggcactctccttatcagcaagatccgagaagaataccct
gatcgcatcatgaataccttcagtgtggtgccttcacccaaagtgtctgacaccgtggtc
gagccctacaatgccaccctctccgtccatcagttggtagagaatactgatgagacctat
tgcattgacaacgaggccctctatgatatctgcttccgcactctgaagctgaccacacca
acctacggggatctgaaccaccttgtctcagccaccatgagtggtgtcaccacctgcctc
cgtttccctggccagctcaatgctgacctccgcaagttggcagtcaacatggtccccttc
ccacgtctccatttctttatgcctggctttgcccctctcaccagccgtggaagccagcag
tatcgagctctcacagtgccggaactcacccagcaggtcttcgatgccaagaacatgatg
gctgcctgtgacccccgccacggccgatacctcaccgtggctgctgtcttccgtggtcgg
atgtccatgaaggaggtcgatgagcagatgcttaacgtgcagaacaagaacagcagctac
tttgtggaatggatccccaacaatgtcaagacagccgtctgtgacatcccacctcgtggc
ctcaagatggcagtcaccttcattggcaatagcacagccatccaggagctcttcaagcgc
atctcggagcagttcactgccatgttccgccggaaggccttcctccactggtacacaggc
gagggcatggacgagatggagttcaccgaggctgagagcaacatgaacgacctcgtctct
gagtatcagcagtaccaggatgccaccgcagaagaggaggaggatttcggtgaggaggcc
gaagaggaggcctaa

KEGG   Homo sapiens (human): 260334
Entry
260334            CDS       T01001                                 
Symbol
TUBB8B, TUBB8P12
Name
(RefSeq) tubulin beta 8B
  KO
K07375  tubulin beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04540  Gap junction
hsa04814  Motor proteins
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    260334 (TUBB8B)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    260334 (TUBB8B)
  09142 Cell motility
   04814 Motor proteins
    260334 (TUBB8B)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    260334 (TUBB8B)
   05132 Salmonella infection
    260334 (TUBB8B)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    260334 (TUBB8B)
   05012 Parkinson disease
    260334 (TUBB8B)
   05014 Amyotrophic lateral sclerosis
    260334 (TUBB8B)
   05016 Huntington disease
    260334 (TUBB8B)
   05020 Prion disease
    260334 (TUBB8B)
   05022 Pathways of neurodegeneration - multiple diseases
    260334 (TUBB8B)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    260334 (TUBB8B)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    260334 (TUBB8B)
   04147 Exosome [BR:hsa04147]
    260334 (TUBB8B)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Microtubules and associated factors
    Other tubulins
     260334 (TUBB8B)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    260334 (TUBB8B)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   260334 (TUBB8B)
  Exosomal proteins of colorectal cancer cells
   260334 (TUBB8B)
  Exosomal proteins of bladder cancer cells
   260334 (TUBB8B)
SSDB
Motif
Pfam: Tubulin Tubulin_C Misat_Tub_SegII Tubulin_3 Tubulin_2
Other DBs
NCBI-GeneID: 260334
NCBI-ProteinID: NP_001345618
HGNC: 24983
Ensembl: ENSG00000173213
LinkDB
Position
18:complement(47212..73539)
AA seq 444 aa
MREIVLTQTGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVHHHEASGGRYV
PRAVLVDLEPGTMDSVHSGPFGQVFRPDNFISGQCGAGNNWAKGRYTEGAELTESVMDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIINTFSILPSPKVSDTVV
EPYNATLSVHQLIENADETFCIDNEALYDICSRTLKLPTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMM
AACDPRHGCYLTVAAIFRGRMPMREVDEQMFNIQDKNSSYFADWFPDNVKTAVCDIPPRG
LKMSATFIGNNAAIQELFTCVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEEDEEYAEEEVA
NT seq 1335 nt   +upstreamnt  +downstreamnt
atgagggaaatcgtgctcacgcagaccgggcagtgcgggaaccagatcggcgccaagttc
tgggaggtgatctctgatgaacatgccatcgactccgctggcacctaccacggggacagc
cacctgcagctggagcgcatcaacgtgcaccaccacgaggccagcggtggcaggtacgtg
ccccgcgctgtgctcgtggatctggagccgggcaccatggactctgtgcactcggggccc
ttcgggcaggtcttcaggccagacaacttcatttccggtcagtgtggggccggaaacaac
tgggccaagggacgctacacagaaggcgcggagctgacggagtcagtgatggacgttgtc
agaaaggaggctgagagctgtgactgcctgcagggtttccagctgacccactccctgggt
ggggggactgggtctgggatgggtacccttctcattagtaagatccgggaggagtaccca
gacaggatcataaacacattcagcatcctgccctcgcccaaggtgtcggacaccgtggtg
gagccctacaacgccaccctctcagtccaccagctcatagaaaacgcggatgagaccttc
tgcatagataacgaagcgctatatgacatatgttccaggaccctaaaactgcccacaccc
acctatggtgacctgaaccacctggtgtctgctaccatgagtggggtcaccacatgcctg
cgcttcccaggccagctgaatgctgacctgcggaagctggccgtgaacatggtcccgttt
ccccggctgcatttcttcatgcccggctttgccccactgaccagccggggcagccagcag
taccgggccttgactgtggctgagctcacccagcagatgtttgatgctaagaacatgatg
gctgcctgtgacccccgtcacggctgctacctaacggtggctgccattttcaggggtcgc
atgcccatgagggaggtggatgaacaaatgttcaacattcaagataagaacagcagctac
tttgctgactggttccccgacaacgtaaaaacagccgtctgtgacatcccaccccggggg
ctaaaaatgtcagccaccttcattgggaataatgcggccatccaggaactcttcacatgt
gtctcagagcagtttacagcaatgttcaggcgcaaggccttcctccactggtacacgggc
gagggcatggatgagatggaattcaccgaggccgagagcaacatgaacgacctggtgtct
gaatatcagcaatatcaggatgccacggccgaggaggaggaggatgaggagtatgccgag
gaggaggtggcctag

KEGG   Homo sapiens (human): 347688
Entry
347688            CDS       T01001                                 
Symbol
TUBB8, OOMD, OOMD2, OZEMA2, bA631M21.2
Name
(RefSeq) tubulin beta 8 class VIII
  KO
K07375  tubulin beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04540  Gap junction
hsa04814  Motor proteins
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
Network
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N00978  Anterograde axonal transport
N00979  Mutation-caused aberrant Htt to anterograde axonal transport
N01018  Mutation-caused aberrant Abeta to anterograde axonal transport
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
N01158  Mutation-caused aberrant DCTN1 to retrograde axonal transport
N01285  Microtubule-RHOA signaling pathway
N01286  Escherichia EspG to Microtubule-RHOA signaling pathway
N01295  Rab7-regulated microtubule minus-end directed transport
N01297  Arl8-regulated microtubule plus-end directed transport
N01298  Salmonella SifA to microtubule plus-end directed transport
N01299  Salmonella PipB2 to microtubule plus-end directed transport
N01403  Zn to anterograde axonal transport
N01414  Iron to anterograde axonal transport
N01535  Kinetochore microtubule attachment
N01544  Microtubule nucleation
N01547  Kinetochore fiber organization
N01549  Branching microtubule nucleation
N01553  Promotion of microtubule growth
N01561  Microtubule depolymerization
N01562  Microtubule depolymerization at the minus ends
Disease
H01897  Oocyte/zygote/embryo maturation arrest
Drug target
Anvatabart opadotin: D12583
Avanbulin: D11681
Batabulin (DG01412): D03059 D06560
Belantamab mafodotin: D11595<US>
Brentuximab vedotin: D09587<JP/US>
Cabazitaxel (DG00695): D09755 D10452<JP/US>
Cantuzumab mertansine: D03364
Cantuzumab ravtansine: D10454
Cevipabulin (DG01413): D06576 D08889
Colchicine: D00570<JP/US>
Denintuzumab mafodotin: D11232
Docetaxel (DG00694): D02165<JP/US> D07866<JP/US>
Enfortumab vedotin: D11525<JP/US>
Eribulin: D08914<JP/US>
Estramustine (DG00724): D02398 D04066 D06397<JP/US>
Farletuzumab ecteribulin: D12183
Glembatumumab vedotin: D09912
Indibulin: D10013
Ixabepilone: D04645<US>
Lexibulin: D10073
Lifastuzumab vedotin: D11238
Lisavanbulin: D11494
Lorvotuzumab mertansine: D09927
Maytansine: D04864
Mecbotamab vedotin: D12220
Mirvetuximab soravtansine: D10954<US>
Mivobulin isethionate: D05062
Oberotatug ravtansine: D12916
Opadotin: D12582
Ozuriftmab vedotin: D12210
Paclitaxel: D00491<JP/US>
Paclitaxel poliglumex: D05333
Sabizabulin (DG03253): D12519 D12520
Soblidotin: D01919
Soravtansine: D11228
Taltobulin: D06001
Tasidotin hydrochloride: D06009
Tirbanibulin (DG03082): D11691<US> D11692
Tisotumab vedotin: D11814<US>
Trastuzumab emtansine: D09980<JP/US>
Tusamitamab ravtansine: D12310
Vedotin: D09691
Verubulin (DG01411): D10029 D10030
Vinblastine (DG00689): D01068<JP/US> D08675
Vincristine (DG00690): D02197<JP/US> D08679
Vindesine (DG00691): D01769<JP> D06304
Vinepidine sulfate: D06305
Vinflunine: D09032
Vinglycinate sulfate: D06306
Vinleurosine sulfate: D06307
Vinorelbine (DG00692): D01935<JP/US> D08680
Vinrosidine sulfate: D06308
Vinzolidine sulfate: D06309
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    347688 (TUBB8)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    347688 (TUBB8)
  09142 Cell motility
   04814 Motor proteins
    347688 (TUBB8)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    347688 (TUBB8)
   05132 Salmonella infection
    347688 (TUBB8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    347688 (TUBB8)
   05012 Parkinson disease
    347688 (TUBB8)
   05014 Amyotrophic lateral sclerosis
    347688 (TUBB8)
   05016 Huntington disease
    347688 (TUBB8)
   05020 Prion disease
    347688 (TUBB8)
   05022 Pathways of neurodegeneration - multiple diseases
    347688 (TUBB8)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    347688 (TUBB8)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    347688 (TUBB8)
   04147 Exosome [BR:hsa04147]
    347688 (TUBB8)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Microtubules and associated factors
    Other tubulins
     347688 (TUBB8)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    347688 (TUBB8)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   347688 (TUBB8)
  Exosomal proteins of colorectal cancer cells
   347688 (TUBB8)
  Exosomal proteins of bladder cancer cells
   347688 (TUBB8)
SSDB
Motif
Pfam: Tubulin Tubulin_C Misat_Tub_SegII Tubulin_3 Tubulin_2
Other DBs
NCBI-GeneID: 347688
NCBI-ProteinID: NP_817124
OMIM: 616768
HGNC: 20773
Ensembl: ENSG00000261456
UniProt: Q3ZCM7
LinkDB
Position
10:complement(46455..76621)
AA seq 444 aa
MREIVLTQIGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVYYNEASGGRYV
PRAVLVDLEPGTMDSVRSGPFGQVFRPDNFIFGQCGAGNNWAKGHYTEGAELMESVMDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLLSKIREEYPDRIINTFSILPSPKVSDTVV
EPYNATLSVHQLIENADETFCIDNEALYDICSKTLKLPTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMM
AACDPRHGRYLTAAAIFRGRMPMREVDEQMFNIQDKNSSYFADWLPNNVKTAVCDIPPRG
LKMSATFIGNNTAIQELFKRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEEDEEYAEEEVA
NT seq 1335 nt   +upstreamnt  +downstreamnt
atgagggagatcgtgctcacgcagatcgggcagtgcgggaatcagatcggcgccaagttc
tgggaggtgatctctgatgaacatgccatcgactccgctggcacctaccacggggacagc
cacctgcagctggagcgcatcaacgtgtactacaacgaggccagcggtggcaggtacgtg
ccccgcgctgtgctcgtggatctggagccgggcaccatggactctgtgcgctcggggccc
ttcgggcaggtcttcaggccagacaacttcatcttcggtcagtgtggggccggaaacaac
tgggccaagggacactacaccgaaggcgcggagctgatggagtcagtgatggacgttgtc
agaaaggaggctgagagctgtgactgcctgcagggtttccagctgacccactccctgggt
ggggggactgggtctgggatgggtacccttctgctcagtaagatccgggaggagtaccca
gacaggatcataaacacattcagcatcctgccctcgcccaaggtgtcggacaccgtggtg
gagccctacaacgccaccctctcagtccaccagctcatagaaaacgcagatgagaccttt
tgcatagataacgaagctctgtatgacatatgttccaagaccctaaaactgcccacaccc
acctatggtgacctgaaccacctggtgtctgctaccatgagtggggtcaccacgtgcctg
cgcttcccgggccagctgaatgctgacctgcggaagctggccgtgaacatggtcccgttt
ccccggctgcatttcttcatgcccggctttgccccactgaccagccggggcagccagcag
taccgggccttgactgtggctgagcttacccagcagatgtttgatgctaagaacatgatg
gctgcctgtgacccccgtcacggccgctacctaacggcggctgccattttcaggggtcgc
atgcccatgagggaggtggatgaacaaatgttcaacattcaagataagaacagcagttac
tttgctgactggctccccaacaacgtaaaaacagccgtctgtgacatcccaccccggggg
ctaaaaatgtcagccaccttcattgggaataatacggccatccaggaactcttcaagcgt
gtctcagagcagtttacagcaatgttcaggcgcaaggccttcctccactggtacacgggc
gagggcatggatgagatggaattcaccgaggccgagagcaacatgaacgacctggtgtct
gaatatcagcaatatcaggatgccacggccgaggaggaggaggatgaggagtatgccgag
gaggaggtggcctag

KEGG   Homo sapiens (human): 347733
Entry
347733            CDS       T01001                                 
Symbol
TUBB2B, CDCBM7, PMGYSA, bA506K6.1
Name
(RefSeq) tubulin beta 2B class IIb
  KO
K07375  tubulin beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04540  Gap junction
hsa04814  Motor proteins
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
Network
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N00978  Anterograde axonal transport
N00979  Mutation-caused aberrant Htt to anterograde axonal transport
N01018  Mutation-caused aberrant Abeta to anterograde axonal transport
N01055  Mutation-caused aberrant SNCA to anterograde axonal transport
N01158  Mutation-caused aberrant DCTN1 to retrograde axonal transport
N01285  Microtubule-RHOA signaling pathway
N01286  Escherichia EspG to Microtubule-RHOA signaling pathway
N01295  Rab7-regulated microtubule minus-end directed transport
N01297  Arl8-regulated microtubule plus-end directed transport
N01298  Salmonella SifA to microtubule plus-end directed transport
N01299  Salmonella PipB2 to microtubule plus-end directed transport
N01403  Zn to anterograde axonal transport
N01414  Iron to anterograde axonal transport
N01535  Kinetochore microtubule attachment
N01544  Microtubule nucleation
N01547  Kinetochore fiber organization
N01549  Branching microtubule nucleation
N01553  Promotion of microtubule growth
N01561  Microtubule depolymerization
N01562  Microtubule depolymerization at the minus ends
Disease
H01881  Complex cortical dysplasia with other brain malformations
Drug target
Anvatabart opadotin: D12583
Avanbulin: D11681
Batabulin (DG01412): D03059 D06560
Belantamab mafodotin: D11595<US>
Brentuximab vedotin: D09587<JP/US>
Cabazitaxel (DG00695): D09755 D10452<JP/US>
Cantuzumab mertansine: D03364
Cantuzumab ravtansine: D10454
Cevipabulin (DG01413): D06576 D08889
Colchicine: D00570<JP/US>
Denintuzumab mafodotin: D11232
Docetaxel (DG00694): D02165<JP/US> D07866<JP/US>
Enfortumab vedotin: D11525<JP/US>
Eribulin: D08914<JP/US>
Estramustine (DG00724): D02398 D04066 D06397<JP/US>
Farletuzumab ecteribulin: D12183
Glembatumumab vedotin: D09912
Indibulin: D10013
Ixabepilone: D04645<US>
Lexibulin: D10073
Lifastuzumab vedotin: D11238
Lisavanbulin: D11494
Lorvotuzumab mertansine: D09927
Maytansine: D04864
Mecbotamab vedotin: D12220
Mirvetuximab soravtansine: D10954<US>
Mivobulin isethionate: D05062
Oberotatug ravtansine: D12916
Opadotin: D12582
Ozuriftmab vedotin: D12210
Paclitaxel: D00491<JP/US>
Paclitaxel poliglumex: D05333
Sabizabulin (DG03253): D12519 D12520
Soblidotin: D01919
Soravtansine: D11228
Taltobulin: D06001
Tasidotin hydrochloride: D06009
Tirbanibulin (DG03082): D11691<US> D11692
Tisotumab vedotin: D11814<US>
Trastuzumab emtansine: D09980<JP/US>
Tusamitamab ravtansine: D12310
Vedotin: D09691
Verubulin (DG01411): D10029 D10030
Vinblastine (DG00689): D01068<JP/US> D08675
Vincristine (DG00690): D02197<JP/US> D08679
Vindesine (DG00691): D01769<JP> D06304
Vinepidine sulfate: D06305
Vinflunine: D09032
Vinglycinate sulfate: D06306
Vinleurosine sulfate: D06307
Vinorelbine (DG00692): D01935<JP/US> D08680
Vinrosidine sulfate: D06308
Vinzolidine sulfate: D06309
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    347733 (TUBB2B)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    347733 (TUBB2B)
  09142 Cell motility
   04814 Motor proteins
    347733 (TUBB2B)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    347733 (TUBB2B)
   05132 Salmonella infection
    347733 (TUBB2B)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    347733 (TUBB2B)
   05012 Parkinson disease
    347733 (TUBB2B)
   05014 Amyotrophic lateral sclerosis
    347733 (TUBB2B)
   05016 Huntington disease
    347733 (TUBB2B)
   05020 Prion disease
    347733 (TUBB2B)
   05022 Pathways of neurodegeneration - multiple diseases
    347733 (TUBB2B)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    347733 (TUBB2B)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    347733 (TUBB2B)
   04147 Exosome [BR:hsa04147]
    347733 (TUBB2B)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Microtubules and associated factors
    Other tubulins
     347733 (TUBB2B)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    347733 (TUBB2B)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   347733 (TUBB2B)
  Exosomal proteins of colorectal cancer cells
   347733 (TUBB2B)
  Exosomal proteins of bladder cancer cells
   347733 (TUBB2B)
SSDB
Motif
Pfam: Tubulin Tubulin_C Misat_Tub_SegII Tubulin_2 Tubulin_3
Other DBs
NCBI-GeneID: 347733
NCBI-ProteinID: NP_821080
OMIM: 612850
HGNC: 30829
Ensembl: ENSG00000137285
UniProt: Q9BVA1 A0A384MEE3
Structure
LinkDB
Position
6:complement(3224277..3227653)
AA seq 445 aa
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM
AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEEGEDEA
NT seq 1338 nt   +upstreamnt  +downstreamnt
atgcgtgagatcgtgcacatccaggcgggccagtgcggcaaccagatcggcgccaagttt
tgggaggtcatcagtgatgagcatgggattgaccccactggcagttaccatggagacagt
gatttgcagctggagagaatcaatgtttactacaatgaagccactggtaacaaatatgtt
cctcgggccatcctcgtggatctggagccaggcacgatggattcggttaggtctggacca
ttcggccagatcttcagaccagacaatttcgtgtttggccagagtggagccgggaataac
tgggccaagggccactacacagagggagccgagctggtcgactcggtcctggatgtggtg
aggaaggagtcagagagctgtgactgtctccagggcttccagctgacccactctctgggg
ggcggcacggggtccgggatgggcaccctgctcatcagcaagatccgggaagagtaccca
gaccgcatcatgaacaccttcagcgtcatgccctcacccaaggtgtcagacacggtggtg
gagccctacaacgccaccctctcggtccaccagctggtggaaaacacagatgaaacctac
tgcattgacaacgaggccctgtatgacatctgcttccgcaccctgaagctgaccaccccc
acctacggggacctcaaccacctggtgtcggccaccatgagcggggtcaccacctgcctg
cgcttcccgggccagctgaacgcagacctgcgcaagctggcggtgaacatggtgcccttc
cctcgcctgcacttcttcatgcccggcttcgcgcccctgaccagccggggcagccagcag
taccgggcgctcacggtgcccgagctcacccagcagatgttcgactccaagaacatgatg
gccgcctgcgacccgcgccacggccgctacctgacggtggctgccatcttccggggccgc
atgtccatgaaggaggtggacgagcagatgctcaacgtgcagaacaagaacagcagctac
ttcgtggagtggatccccaacaacgtgaagacggccgtgtgcgacatcccgccccgcggc
ctgaagatgtcggccaccttcatcggcaacagcacggccatccaggagctgttcaagcgc
atctccgagcagttcacggccatgttccggcgcaaggccttcctgcactggtacacgggc
gagggcatggacgagatggagttcaccgaggccgagagcaacatgaacgacctggtgtcc
gagtaccagcagtaccaggacgccacggccgacgaacaaggggagttcgaggaggaggag
ggcgaggacgaggcgtag

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