Homo sapiens (human): 10401 Help Entry 10401             CDS       T01001                                  Symbol PIAS3, ZMIZ5 Name (RefSeq) protein inhibitor of activated STAT 3   KO K16064   E3 SUMO-protein ligase PIAS3 [EC:2.3.2.-] Organism hsa  Homo sapiens (human) Pathway hsa04120   Ubiquitin mediated proteolysis hsa04630   JAK-STAT signaling pathway Brite KEGG Orthology (KO) [BR:hsa00001]  09120 Genetic Information Processing   09123 Folding, sorting and degradation    04120 Ubiquitin mediated proteolysis     10401 (PIAS3)  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     10401 (PIAS3)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:hsa04121]     10401 (PIAS3) Ubiquitin system [BR:hsa04121]  Ubiquitin ligases (E3)   UBL E3 ligases    10401 (PIAS3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PINIT zf-MIZ zf-Nse Motif Other DBs NCBI-GeneID:  10401 NCBI-ProteinID:  NP_006090 OMIM:  605987 HGNC:  16861 Ensembl:  ENSG00000131788 Pharos:  Q9Y6X2(Tbio) UniProt:  Q9Y6X2 B3KNI3 Structure PDBPDBj LinkDB All DBs Position 1:complement(145848522..145859081) Genome browser AA seq 628 aa AA seqDB search MAELGELKHMVMSFRVSELQVLLGFAGRNKSGRKHELLAKALHLLKSSCAPSVQMKIKEL YRRRFPRKTLGPSDLSLLSLPPGTSPVGSPGPLAPIPPTLLAPGTLLGPKREVDMHPPLP QPVHPDVTMKPLPFYEVYGELIRPTTLASTSSQRFEEAHFTFALTPQQVQQILTSREVLP GAKCDYTIQVQLRFCLCETSCPQEDYFPPNLFVKVNGKLCPLPGYLPPTKNGAEPKRPSR PINITPLARLSATVPNTIVVNWSSEFGRNYSLSVYLVRQLTAGTLLQKLRAKGIRNPDHS RALIKEKLTADPDSEVATTSLRVSLMCPLGKMRLTVPCRALTCAHLQSFDAALYLQMNEK KPTWTCPVCDKKAPYESLIIDGLFMEILSSCSDCDEIQFMEDGSWCPMKPKKEASEVCPP PGYGLDGLQYSPVQGGDPSENKKKVEVIDLTIESSSDEEDLPPTKKHCSVTSAAIPALPG SKGVLTSGHQPSSVLRSPAMGTLGGDFLSSLPLHEYPPAFPLGADIQGLDLFSFLQTESQ HYGPSVITSLDEQDALGHFFQYRGTPSHFLGPLAPTLGSSHCSATPAPPPGRVSSIVAPG GALREGHGGPLPSGPSLTGCRSDIISLD NT seq 1887 nt NT seq  +upstreamnt  +downstreamnt atggcggagctgggcgaattaaagcacatggtgatgagtttccgggtgtctgagctccag gtgcttcttggctttgctggccggaacaagagtggacggaagcacgagctcctggccaag gctctgcacctcctgaagtccagctgtgcccctagtgtccagatgaagatcaaagagctt taccgacgacgctttccccggaagaccctggggccctctgatctctcccttctctctttg ccccctggcacctctcctgtaggctcccctggtcctctagctcccattcccccaacgctg ttggcccctggcaccctgctgggccccaagcgtgaggtggacatgcacccccctctgccc cagcctgtgcaccctgatgtcaccatgaaaccattgcccttctatgaagtctatggggag ctcatccggcccaccacccttgcatccacttctagccagcggtttgaggaagcgcacttt acctttgccctcacaccccagcaagtgcagcagattcttacatccagagaggttctgcca ggagccaaatgtgattataccatacaggtgcagctaaggttctgtctctgtgagaccagc tgcccccaggaagattattttccccccaacctctttgtcaaggtcaatgggaaactgtgc cccctgccgggttaccttcccccaaccaagaatggggccgagcccaagaggcccagccgc cccatcaacatcacacccctggctcgactctcagccactgttcccaacaccattgtggtc aattggtcatctgagttcggacggaattactccttgtctgtgtacctggtgaggcagttg actgcaggaacccttctacaaaaactcagagcaaagggtatccggaacccagaccactcg cgggcactgatcaaggagaaattgactgctgaccctgacagtgaggtggccactacaagt ctccgggtgtcactcatgtgcccgctagggaagatgcgcctgactgtcccttgtcgtgcc ctcacctgcgcccacctgcagagcttcgatgctgccctttatctacagatgaatgagaag aagcctacatggacatgtcctgtgtgtgacaagaaggctccctatgaatctcttatcatt gatggtttatttatggagattcttagttcctgttcagattgtgatgagatccaattcatg gaagatggatcctggtgcccaatgaaacccaagaaggaggcatctgaggtttgccccccg ccagggtatgggctggatggcctccagtacagcccagtccaggggggagatccatcagag aataagaagaaggtcgaagttattgacttgacaatagaaagctcatcagatgaggaggat ctgccccctaccaagaagcactgttctgtcacctcagctgccatcccggccctacctgga agcaaaggagtcctgacatctggccaccagccatcctcggtgctaaggagccctgctatg ggcacgttgggtggggatttcctgtccagtctcccactacatgagtacccacctgccttc ccactgggagccgacatccaaggtttagatttattttcatttcttcagacagagagtcag cactatggcccctctgtcatcacctcactagatgaacaggatgcccttggccacttcttc cagtaccgagggaccccttctcactttctgggcccactggcccccacgctggggagctcc cactgcagcgccactccggcgccccctcctggccgtgtcagcagcattgtggcccctggg ggggccttgagggaggggcatggaggacccctgccctcaggtccctctttgactggctgt cggtcagacatcatttccctggactga

Homo sapiens (human): 51588 Help Entry 51588             CDS       T01001                                  Symbol PIAS4, PIAS-gamma, PIASY, Piasg, ZMIZ6 Name (RefSeq) protein inhibitor of activated STAT 4   KO K16065   E3 SUMO-protein ligase PIAS4 [EC:2.3.2.27] Organism hsa  Homo sapiens (human) Pathway hsa04064   NF-kappa B signaling pathway hsa04120   Ubiquitin mediated proteolysis hsa04630   JAK-STAT signaling pathway hsa05418   Fluid shear stress and atherosclerosis Network nt06506  Double-strand break repair   Element N01439   Double-strand break signaling Brite KEGG Orthology (KO) [BR:hsa00001]  09120 Genetic Information Processing   09123 Folding, sorting and degradation    04120 Ubiquitin mediated proteolysis     51588 (PIAS4)  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     51588 (PIAS4)    04064 NF-kappa B signaling pathway     51588 (PIAS4)  09160 Human Diseases   09166 Cardiovascular disease    05418 Fluid shear stress and atherosclerosis     51588 (PIAS4)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:hsa04121]     51588 (PIAS4) Enzymes [BR:hsa01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.27  RING-type E3 ubiquitin transferase      51588 (PIAS4) Ubiquitin system [BR:hsa04121]  Ubiquitin ligases (E3)   UBL E3 ligases    51588 (PIAS4) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PINIT zf-MIZ zf-Nse DARPP-32 SAP Motif Other DBs NCBI-GeneID:  51588 NCBI-ProteinID:  NP_056981 OMIM:  605989 HGNC:  17002 Ensembl:  ENSG00000105229 Pharos:  Q8N2W9(Tbio) UniProt:  Q8N2W9 B3KMR4 LinkDB All DBs Position 19:4007736..4039386 Genome browser AA seq 510 aa AA seqDB search MAAELVEAKNMVMSFRVSDLQMLLGFVGRSKSGLKHELVTRALQLVQFDCSPELFKKIKE LYETRYAKKNSEPAPQPHRPLDPLTMHSTYDRAGAVPRTPLAGPNIDYPVLYGKYLNGLG RLPAKTLKPEVRLVKLPFFNMLDELLKPTELVPQNNEKLQESPCIFALTPRQVELIRNSR ELQPGVKAVQVVLRICYSDTSCPQEDQYPPNIAVKVNHSYCSVPGYYPSNKPGVEPKRPC RPINLTHLMYLSSATNRITVTWGNYGKSYSVALYLVRQLTSSELLQRLKTIGVKHPELCK ALVKEKLRLDPDSEIATTGVRVSLICPLVKMRLSVPCRAETCAHLQCFDAVFYLQMNEKK PTWMCPVCDKPAPYDQLIIDGLLSKILSECEDADEIEYLVDGSWCPIRAEKERSCSPQGA ILVLGPSDANGLLPAPSVNGSGALGSTGGGGPVGSMENGKPGADVVDLTLDSSSSSEDEE EEEEEEEDEDEEGPRPKRRCPFQKGLVPAC NT seq 1533 nt NT seq  +upstreamnt  +downstreamnt atggcggcggagctggtggaggccaaaaacatggtgatgagttttcgagtctccgacctt cagatgctcctgggtttcgtgggccggagtaagagtggactgaagcacgagctcgtcacc agggccctccagctggtgcagtttgactgtagccctgagctgttcaagaagatcaaggag ctgtacgagacccgctacgccaagaagaactcggagcctgccccacagccgcaccggccc ctggaccccctgaccatgcactccacctacgaccgggccggcgctgtgcccaggactccg ctggcaggccccaatattgactaccccgtgctctacggaaagtacttaaacggactggga cggttgcccgccaagaccctcaagccagaagtccgcctggtgaagctgccgttctttaat atgctggatgagctgctgaagcccaccgaattagtcccacagaacaacgagaagcttcag gagagcccgtgcatcttcgcattgacgccaagacaggtggagttgatccggaactccagg gaactgcagcccggagttaaagccgtgcaggtcgtcctgagaatctgttactcagacacc agctgccctcaggaggaccagtacccgcccaacatcgctgtgaaggtcaaccacagctac tgctccgtcccgggctactacccctccaataagcccggggtggagcccaagaggccgtgc cgccccatcaacctcacccacctcatgtacctgtcctcggccaccaaccgcatcactgtc acctgggggaactacggcaagagctactcggtggccctgtacctggtgcggcagctgacc tcatcggagctgctgcagaggctgaagaccattggggtaaagcacccggagctgtgcaag gcactggtcaaggagaagctgcgccttgatcctgacagcgagatcgccaccaccggtgtg cgggtgtccctcatctgtccgctggtgaagatgcggctctccgtgccctgccgggcagag acctgtgcccacctgcagtgcttcgacgccgtcttctacctgcagatgaacgagaagaag cccacctggatgtgccccgtgtgcgacaagccagccccctacgaccagctcatcatcgac gggctcctctcgaagatcctgagcgagtgtgaggacgccgacgagatcgagtacctggtg gacggctcgtggtgcccgatccgcgccgaaaaggagcgcagctgcagcccgcagggcgcc atcctcgtgctgggcccctcggacgccaatgggctcctgcccgcccccagcgtcaacggg agcggtgccctgggcagcacgggtggcggcggcccggtgggcagcatggagaatgggaag ccgggcgccgatgtggtggacctcacgctggacagctcatcgtcctcggaggatgaggag gaggaggaagaggaggaggaagacgaggacgaagaggggccccggcccaagcgccgctgc cccttccagaagggcctggtgccggcctgctga

Homo sapiens (human): 8554 Help Entry 8554              CDS       T01001                                  Symbol PIAS1, DDXBP1, GBP, GU/RH-II, ZMIZ3 Name (RefSeq) protein inhibitor of activated STAT 1   KO K04706   E3 SUMO-protein ligase PIAS1 [EC:2.3.2.-] Organism hsa  Homo sapiens (human) Pathway hsa04120   Ubiquitin mediated proteolysis hsa04630   JAK-STAT signaling pathway hsa05160   Hepatitis C Brite KEGG Orthology (KO) [BR:hsa00001]  09120 Genetic Information Processing   09123 Folding, sorting and degradation    04120 Ubiquitin mediated proteolysis     8554 (PIAS1)  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     8554 (PIAS1)  09160 Human Diseases   09172 Infectious disease: viral    05160 Hepatitis C     8554 (PIAS1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:hsa04121]     8554 (PIAS1)   09183 Protein families: signaling and cellular processes    04812 Cytoskeleton proteins [BR:hsa04812]     8554 (PIAS1) Ubiquitin system [BR:hsa04121]  Ubiquitin ligases (E3)   UBL E3 ligases    8554 (PIAS1) Cytoskeleton proteins [BR:hsa04812]  Eukaryotic cytoskeleton proteins   Septins    Septin associated proteins     8554 (PIAS1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PINIT zf-MIZ zf-Nse Motif Other DBs NCBI-GeneID:  8554 NCBI-ProteinID:  NP_057250 OMIM:  603566 HGNC:  2752 Ensembl:  ENSG00000033800 Pharos:  O75925(Tbio) UniProt:  O75925 Structure PDBPDBj LinkDB All DBs Position 15:68054315..68193847 Genome browser AA seq 651 aa AA seqDB search MADSAELKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKEL YRRRFPQKIMTPADLSIPNVHSSPMPATLSPSTIPQLTYDGHPASSPLLPVSLLGPKHEL ELPHLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDNSQRFRETCFAFALTPQQVQQ ISSSMDISGTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNTKPCSLPGYLPPTKNG VEPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIGRNYSMAVYLVKQLSSTVLLQRLRAK GIRNPDHSRALIKEKLTADPDSEIATTSLRVSLLCPLGKMRLTIPCRALTCSHLQCFDAT LYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILKYCTDCDEIQFKEDGTWAPMRSKK EVQEVSASYNGVDGCLSSTLEHQVASHHQSSNKNKKVEVIDLTIDSSSDEEEEEPSAKRT CPSLSPTSPLNNKGILSLPHQASPVSRTPSLPAVDTSYINTSLIQDYRHPFHMTPMPYDL QGLDFFPFLSGDNQHYNTSLLAAAAAAVSDDQDLLHSSRFFPYTSSQMFLDQLSAGGSTS LPTTNGSSSGSNSSLVSSNSLRESHSHTVTNRSSTDTASIFGIIPDIISLD NT seq 1956 nt NT seq  +upstreamnt  +downstreamnt atggcggacagtgcggaactaaagcaaatggttatgagccttagagtttctgaactccaa gtactgttgggctacgccgggagaaacaagcacggacgcaaacacgaacttctcacaaaa gccctgcatttgctaaaggctggctgtagtcctgctgtgcaaatgaaaattaaggaactc tataggcggcggttcccacagaaaatcatgacgcctgcagacttgtccatccccaacgta cattcaagtcctatgccagcaactttgtctccatctaccattccacaactcacttacgat ggtcaccctgcatcatcgccattactccctgtttctcttctgggacctaaacatgaactg gaactcccacatcttacatcagctcttcacccagtccatccggatataaaacttcaaaaa ttaccattttatgatttactggatgaactgataaaacccaccagtctagcatcagacaac agtcagcgctttcgagaaacctgttttgcatttgccttgacaccacaacaagtgcagcaa atcagtagttccatggatatttctgggaccaaatgtgacttcacagtacaggtccagtta aggttttgtttatcagaaaccagttgtccacaagaagatcacttcccacccaatctttgt gtgaaagtgaatacaaaaccttgcagccttccaggttaccttccacctacaaaaaatggc gtggaaccaaagcgacccagccgaccaattaatatcacctcacttgtccgactgtccaca acagtaccaaacacgattgttgtttcttggactgcagaaattggaagaaactattccatg gcagtatatcttgtaaaacagttgtcctcaacagttcttcttcagaggttacgagcaaag ggaataaggaatccggatcattctagagctttaattaaagagaagttgactgcggatcca gacagtgaaatagctacaaccagcctaagggtttctctactatgtccacttggtaaaatg cggctgacaattccgtgtcgggcccttacatgttctcatctacaatgttttgacgcaact ctttacattcagatgaatgagaaaaaaccaacctgggtttgtcctgtctgtgataagaag gctccatatgaacaccttattattgatggcttgtttatggaaatcctaaagtactgtaca gactgtgatgaaatacaatttaaggaggatggcacttgggcaccgatgagatcaaaaaag gaagtacaggaagtttctgcctcttacaatggagtcgatggatgcttgagctccacattg gagcatcaggtagcgtctcaccaccagtcctcaaataaaaacaagaaagtagaagtgatt gacctaaccatagacagttcatctgatgaagaggaagaagagccatctgccaagaggacc tgtccttccctatctcccacatcaccactaaataataaaggcattttaagtcttccacat caagcatctccagtatcccgcaccccaagccttcctgctgtagacacaagctacattaat acctccctcatccaagactataggcatcctttccacatgacacccatgccttacgactta caaggattagatttctttcctttcttatcaggagacaatcagcattacaacacctccttg cttgccgctgcagcagcagcagtttcagatgatcaagacctcctacactcgtctcggttt ttcccgtatacctcctcacagatgtttcttgatcagttaagtgcaggaggcagtacttct ctgccaaccaccaatggaagcagtagtggcagtaacagcagcctggtttcttccaacagc ctaagggaaagccatagccacaccgtcacaaacaggagcagcacggacacggcatccatc tttggcatcataccagacattatttcattggactga

Homo sapiens (human): 9063 Help Entry 9063              CDS       T01001                                  Symbol PIAS2, ARIP3, DIP, MIZ1, PIASX, SIZ2, ZMIZ4 Name (RefSeq) protein inhibitor of activated STAT 2   KO K16063   E3 SUMO-protein ligase PIAS2 [EC:2.3.2.-] Organism hsa  Homo sapiens (human) Pathway hsa04120   Ubiquitin mediated proteolysis hsa04630   JAK-STAT signaling pathway Brite KEGG Orthology (KO) [BR:hsa00001]  09120 Genetic Information Processing   09123 Folding, sorting and degradation    04120 Ubiquitin mediated proteolysis     9063 (PIAS2)  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     9063 (PIAS2)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:hsa04121]     9063 (PIAS2) Ubiquitin system [BR:hsa04121]  Ubiquitin ligases (E3)   UBL E3 ligases    9063 (PIAS2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PINIT zf-MIZ zf-Nse SAP Motif Other DBs NCBI-GeneID:  9063 NCBI-ProteinID:  NP_004662 OMIM:  603567 HGNC:  17311 Ensembl:  ENSG00000078043 Pharos:  O75928(Tbio) UniProt:  O75928 Structure PDBPDBj LinkDB All DBs Position 18:complement(46803218..46920145) Genome browser AA seq 621 aa AA seqDB search MADFEELRNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIREL YRRRYPRTLEGLSDLSTIKSSVFSLDGGSSPVEPDLAVAGIHSLPSTSVTPHSPSSPVGS VLLQDTKPTFEMQQPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQRFQEKFFI FALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFP LPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQISISWASEIGKNYSMSVYLVRQLT SAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAV TCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCSDVDEIKFQE DGSWCPMRPKKEAMKVSSQPCTKIESSSVLSKPCSVTVASEASKKKVDVIDLTIESSSDE EEDPPAKRKCIFMSETQSSPTKGVLMYQPSSVRVPSVTSVDPAAIPPSLTDYSVPFHHTP ISSMSSDLPGLDFLSLIPVDPQYCPPMFLDSLTSPLTASSTSVTTTSSHESSTHVSSSSS RSETGVITSSGSNIPDIISLD NT seq 1866 nt NT seq  +upstreamnt  +downstreamnt atggcggatttcgaagagttgaggaatatggtttctagttttagggtttctgaactacaa gtattactaggctttgctggacggaataaaagtggacgcaagcatgacctcctgatgagg gcgctgcatttattgaagagcggctgcagccctgcggttcagattaaaatccgagaattg tatagacgccgatatccacgaactcttgaaggactttctgatttatccacaatcaaatca tcggttttcagtttggatggtggctcatcacctgtagaacctgacttggccgtggctgga atccactcgttgccttccacttcagttacacctcactcaccatcctctcctgttggttct gtgctgcttcaagatactaagcccacatttgagatgcagcagccatctcccccaattcct cctgtccatcctgatgtgcagttaaaaaatctgcccttttatgatgtccttgatgttctc atcaagcccacgagtttagttcaaagcagtattcagcgatttcaagagaagttttttatt tttgctttgacacctcaacaagttagagagatatgcatatccagggattttttgccaggt ggtaggagagattatacagtccaagttcagttgagactttgcctggcagagacaagttgc cctcaagaagataactatccaaatagtctatgtataaaagtaaatgggaagctatttcct ttgcctggctatgcaccaccgcctaaaaatgggattgaacagaagcgccctggacgcccc ttgaatattacatctttagttaggttatcttcagctgtgccaaaccaaatttccatttct tgggcatcagaaattgggaagaattactctatgtctgtatatcttgtacggcagcttaca tcagccatgttattacagagattaaaaatgaaaggtattagaaaccctgatcattccaga gcactaattaaagaaaaacttactgcagatcctgatagtgaaattgctacaactagcctt cgggtatccttgatgtgccctttaggaaaaatgaggctgacaatcccatgccgtgcagtg acttgtacacatctgcagtgttttgatgctgccctctatctacaaatgaatgagaaaaag cccacctggatttgtcctgtgtgtgacaaaaaagctgcctatgaaagtctaatattagat gggctttttatggaaattctcaatgactgttctgatgtagatgagatcaaattccaagaa gatggttcttggtgtccaatgagaccgaagaaagaagctatgaaagtatccagccaaccg tgtacaaaaatagaaagttcaagcgtcctcagtaagccttgttcagtgactgtagccagt gaggcaagcaagaagaaagtagatgttattgatcttacaatagaaagctcttctgacgaa gaggaagaccctcctgccaaaaggaaatgcatctttatgtcagaaacacaaagcagccca accaaaggggttctcatgtatcagccatcttctgtaagggtgcccagtgtgacttcggtt gatcctgctgctattccgccttcattaacagactactcagtaccattccaccatacgcca atatcaagcatgtcatcagatttgccaggtttggattttctttcccttattccagttgat ccccagtactgtcctcctatgtttttggatagtctcacctcacccttaacagcaagcagt acgtctgtcaccaccaccagctcccatgaaagcagtactcatgttagttcatccagcagc aggagtgagacaggggtcataaccagcagtggaagtaacattcctgacatcatctcattg gactaa

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