Homo sapiens (human): 10451 Help Entry 10451             CDS       T01001                                  Symbol VAV3 Name (RefSeq) vav guanine nucleotide exchange factor 3   KO K05730   guanine nucleotide exchange factor VAV Organism hsa  Homo sapiens (human) Pathway hsa04015   Rap1 signaling pathway hsa04024   cAMP signaling pathway hsa04062   Chemokine signaling pathway hsa04510   Focal adhesion hsa04650   Natural killer cell mediated cytotoxicity hsa04660   T cell receptor signaling pathway hsa04662   B cell receptor signaling pathway hsa04664   Fc epsilon RI signaling pathway hsa04666   Fc gamma R-mediated phagocytosis hsa04670   Leukocyte transendothelial migration hsa04810   Regulation of actin cytoskeleton hsa05135   Yersinia infection hsa05205   Proteoglycans in cancer hsa05417   Lipid and atherosclerosis Network nt06183  Yersinia nt06537  TCR/BCR signaling   Element N01106   TCR-PLCG-ITPR signaling pathway N01108   Yersinia YopH to TCR-NFAT signaling pathway Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     10451 (VAV3)    04024 cAMP signaling pathway     10451 (VAV3)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     10451 (VAV3)   09142 Cell motility    04810 Regulation of actin cytoskeleton     10451 (VAV3)  09150 Organismal Systems   09151 Immune system    04650 Natural killer cell mediated cytotoxicity     10451 (VAV3)    04660 T cell receptor signaling pathway     10451 (VAV3)    04662 B cell receptor signaling pathway     10451 (VAV3)    04664 Fc epsilon RI signaling pathway     10451 (VAV3)    04666 Fc gamma R-mediated phagocytosis     10451 (VAV3)    04670 Leukocyte transendothelial migration     10451 (VAV3)    04062 Chemokine signaling pathway     10451 (VAV3)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     10451 (VAV3)   09171 Infectious disease: bacterial    05135 Yersinia infection     10451 (VAV3)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     10451 (VAV3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RhoGEF SH3_2 CAMSAP_CH CH SH3_1 SH2 SH3_9 C1_1 PH CDC24 Filamin LZ3wCH PH_10 zf-RING-like C1_2 Prok-RING_1 zf-RING_16 Motif Other DBs NCBI-GeneID:  10451 NCBI-ProteinID:  NP_006104 OMIM:  605541 HGNC:  12659 Ensembl:  ENSG00000134215 UniProt:  Q9UKW4 Structure PDB LinkDB All DBs Position 1:complement(107571161..107965180) Genome browser AA seq 847 aa AA seqDB search MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI ALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAE EAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPE LVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKE DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDA MKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQER HIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGL EFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQ GYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVI RNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPC VPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIK ILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRA GNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPS TYVEEDE NT seq 2544 nt NT seq  +upstreamnt  +downstreamnt atggagccgtggaagcagtgcgcgcagtggctcatccattgcaaggtgctgcccaccaac caccgggtgacctgggactcggctcaggtgttcgaccttgcgcagaccctccgcgatgga gtcctgctctgccagctgcttaacaacctccgggcgcactccatcaacctgaaggagatc aacctgaggccgcagatgtcccagtttctctgtttgaagaacataaggacatttctcacg gcctgttgtgagacgtttggaatgaggaaaagtgaacttttcgaggcatttgacttgttt gatgttcgtgactttggaaaggttatagaaacattatcacgactttctcgaacacctata gcattggccacaggaatcaggcccttcccaacagaagaaagcattaatgatgaagacatc tacaaaggccttcctgatttaatagatgaaacccttgtggaagatgaagaagatctctat gactgtgtttatggggaagatgaaggtggagaagtctatgaggacttaatgaaggcagag gaagcacatcagcccaaatgtccagaaaatgatatacgaagttgttgtctagcagaaatt aagcagacagaagaaaaatatacagaaactttggagtcaatagaaaagtatttcatggca ccactaaaaagatttctgacagcagcagaatttgattcagtattcatcaacattcctgaa cttgtaaaacttcatcggaacctaatgcaagagattcatgattccattgtaaataaaaat gaccagaacttgtaccaagtttttattaactacaaggaaagattggttatttacgggcag tactgcagtggagtggagtcagccatctctagtttagactacatttctaagacaaaagaa gatgtcaaactgaaattagaggaatgttccaaaagagcaaataatgggaaatttactctt cgagacttgcttgtggttcctatgcaacgtgttttaaagtaccaccttctcctccaggaa ctggtcaaacataccactgatccgactgagaaggcaaatctgaaactggctcttgatgcc atgaaggacttggcacaatatgtgaatgaagtgaaaagagataatgagacccttcgtgaa attaaacagtttcagctatctatagagaatttgaaccaaccagttttgctttttggacga cctcagggagatggtgaaattcgaataaccactctagacaagcataccaaacaagaaagg catatcttcttatttgatttggcagtgatcgtatgtaagagaaaaggtgataactatgaa atgaaggaaataatagatcttcagcagtacaagatagccaataatcctacaaccgataaa gaaaacaaaaagtggtcttatggcttctacctcatccatacccaaggacaaaatgggtta gaattttattgcaaaacaaaagatttaaagaagaaatggctagaacagtttgaaatggct ttgtctaacataagaccagactatgcagactccaatttccacgacttcaagatgcatacc ttcactcgagtcacatcctgcaaagtctgccagatgctcctgaggggaacattttatcaa ggctatttatgttttaagtgtggagcgagagcacacaaagaatgtttgggaagagtagac aattgtggcagagttaattctggtgaacaagggacactcaaactaccagagaaacggacc aatggactgcgaagaactcctaaacaggtggatccaggtttaccaaagatgcaggtcatt aggaactattctggaacaccacccccagctctgcatgaaggaccccctttacagctccag gccggggataccgttgaacttctgaaaggagatgcacacagtctgttttggcagggcaga aatttagcatctggagaggttggattttttccaagtgatgcagtcaagccttgcccatgt gtgcccaaaccagtagattattcttgccaaccctggtatgctggagcaatggaaagattg caagcagagaccgaacttattaatagggtaaatagtacttaccttgtgaggcacaggacc aaagagtcaggagaatatgcaattagcattaagtacaataatgaagcaaagcacatcaag attttaacaagagatggcttttttcacattgcagaaaatagaaaatttaaaagtttaatg gaacttgtggagtactacaagcatcattctctcaaggaagggttcagaaccttagataca actctgcagtttccatacaaggagccagaacattcagctggacagaggggtaatagagca ggcaacagcttgttaagtccaaaagtgctgggcattgccatcgctcggtatgacttctgt gcaagagatatgagagagttgtccttgttgaaaggagatgtggtgaagatttacacaaag atgagtgcaaatggctggtggagaggagaagtaaatggcagggtgggctggtttccatcc acatatgtggaagaggatgaataa

Homo sapiens (human): 7074 Help Entry 7074              CDS       T01001                                  Symbol TIAM1, NEDLDS, TIAM-1 Name (RefSeq) TIAM Rac1 associated GEF 1   KO K05731   T-lymphoma invasion and metastasis-inducing protein 1 Organism hsa  Homo sapiens (human) Pathway hsa04014   Ras signaling pathway hsa04015   Rap1 signaling pathway hsa04024   cAMP signaling pathway hsa04062   Chemokine signaling pathway hsa04530   Tight junction hsa04810   Regulation of actin cytoskeleton hsa05205   Proteoglycans in cancer Disease H02459   Syndromic neurodevelopmental disorder Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04014 Ras signaling pathway     7074 (TIAM1)    04015 Rap1 signaling pathway     7074 (TIAM1)    04024 cAMP signaling pathway     7074 (TIAM1)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04530 Tight junction     7074 (TIAM1)   09142 Cell motility    04810 Regulation of actin cytoskeleton     7074 (TIAM1)  09150 Organismal Systems   09151 Immune system    04062 Chemokine signaling pathway     7074 (TIAM1)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     7074 (TIAM1)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04990 Domain-containing proteins not elsewhere classified [BR:hsa04990]     7074 (TIAM1) Domain-containing proteins not elsewhere classified [BR:hsa04990]  Pleckstrin homology (PH) domain-containing proteins   Dbl-Like RhoGEF family proteins    7074 (TIAM1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Tiam_CC_Ex RhoGEF PH RBD PH_9 PDZ PDZ_2 PDZ_6 PH_11 RNA_pol_Rpc82 Motif Other DBs NCBI-GeneID:  7074 NCBI-ProteinID:  NP_003244 OMIM:  600687 HGNC:  11805 Ensembl:  ENSG00000156299 UniProt:  Q13009 A0A2X0TW27 Structure PDB LinkDB All DBs Position 21:complement(31118418..31559087) Genome browser AA seq 1591 aa AA seqDB search MGNAESQHVEHEFYGEKHASLGRKHTSRSLRLSHKTRRTRHASSGKVIHRNSEVSTRSSS TPSIPQSLAENGLEPFSQDGTLEDFGSPIWVDRVDMGLRPVSYTDSSVTPSVDSSIVLTA ASVQSMPDTEESRLYGDDATYLAEGGRRQHSYTSNGPTFMETASFKKKRSKSADIWREDS LEFSLSDLSQEHLTSNEEILGSAEEKDCEEARGMETRASPRQLSTCQRANSLGDLYAQKN SGVTANGGPGSKFAGYCRNLVSDIPNLANHKMPPAAAEETPPYSNYNTLPCRKSHCLSEG ATNPQISHSNSMQGRRAKTTQDVNAGEGSEFADSGIEGATTDTDLLSRRSNATNSSYSPT TGRAFVGSDSGSSSTGDAARQGVYENFRRELEMSTTNSESLEEAGSAHSDEQSSGTLSSP GQSDILLTAAQGTVRKAGALAVKNFLVHKKNKKVESATRRKWKHYWVSLKGCTLFFYESD GRSGIDHNSIPKHAVWVENSIVQAVPEHPKKDFVFCLSNSLGDAFLFQTTSQTELENWIT AIHSACATAVARHHHKEDTLRLLKSEIKKLEQKIDMDEKMKKMGEMQLSSVTDSKKKKTI LDQIFVWEQNLEQFQMDLFRFRCYLASLQGGELPNPKRLLAFASRPTKVAMGRLGIFSVS SFHALVAARTGETGVRRRTQAMSRSASKRRSRFSSLWGLDTTSKKKQGRPSINQVFGEGT EAVKKSLEGIFDDIVPDGKREKEVVLPNVHQHNPDCDIWVHEYFTPSWFCLPNNQPALTV VRPGDTARDTLELICKTHQLDHSAHYLRLKFLIENKMQLYVPQPEEDIYELLYKEIEICP KVTQSIHIEKSDTAADTYGFSLSSVEEDGIRRLYVNSVKETGLASKKGLKAGDEILEINN RAADALNSSMLKDFLSQPSLGLLVRTYPELEEGVELLESPPHRVDGPADLGESPLAFLTS NPGHSLCSEQGSSAETAPEETEGPDLESSDETDHSSKSTEQVAAFCRSLHEMNPSDQSPS PQDSTGPQLATMRQLSDADKLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLTQDE LDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFK LYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLL RELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQLIAEQTGEKKEVA DLSMGDLLLHTTVIWLNPPASLGKWKKEPELAAFVFKTAVVLVYKDGSKQKKKLVGSHRL SIYEDWDPFRFRHMIPTEALQVRALASADAEANAVCEIVHVKSESEGRPERVFHLCCSSP ESRKDFLKAVHSILRDKHRRQLLKTESLPSSQQYVPFGGKRLCALKGARPAMSRAVSAPS KSLGRRRRRLARNRFTIDSDAVSASSPEKESQQPPGGGDTDRWVEEQFDLAQYEEQDDIK ETDILSDDDEFCESVKGASVDRDLQERLQATSISQRERGRKTLDSHASRMAQLKKQAALS GINGGLESASEEVIWVRREDFAPSRKLNTEI NT seq 4776 nt NT seq  +upstreamnt  +downstreamnt atgggaaacgcagaaagtcaacatgtagagcacgagttttatggagaaaagcatgccagc ctggggcgcaagcacacttcccgctccctgcgcctctcgcacaagacgcggaggaccagg cacgcttcctcggggaaggtgatccacaggaactccgaagtgagcacccgatccagcagc acccccagcatcccccagtccctggctgaaaatggcctggagcccttctcccaagatggt accctagaagacttcgggagccccatctgggtggaccgagtggacatgggcttgagacct gtgtcttacactgactcttctgtcactcccagcgtagacagcagcatcgtcctcacagca gcctctgtgcagagcatgccagacactgaggagagcaggctttacggggatgacgctaca tatttggctgagggaggcaggaggcagcattcctatacatccaatgggcccactttcatg gagacggcgagctttaagaagaaacgctccaaatctgcagacatctggcgggaggacagc ctggaattctcactctctgatctgagccaagaacatttaacaagcaacgaagaaatcttg ggttccgccgaagagaaggactgcgaggaggctcgggggatggaaacgcgggcgagtccg cggcagctcagcacctgtcagagagccaattccttgggtgacttgtatgctcagaaaaac tctggagtgacagcaaacggggggccggggagcaaatttgcaggctactgtcggaatttg gtgtctgatattcccaatcttgcaaaccataagatgccaccagctgctgctgaagagact cctccgtacagtaattataacacacttccctgtaggaaatctcactgtctctctgaaggt gccaccaacccacaaattagccatagcaacagcatgcaaggcagaagagctaaaacaact caggatgttaatgcaggcgagggcagtgagtttgcagacagtgggattgaaggggccact accgacacggacctcctgtccaggcgatctaatgccaccaactccagctactcacccacc acaggccgggcctttgtgggcagcgacagcggcagcagctccaccggggatgcggctcgt cagggggtgtacgagaacttccggcgggagctggagatgagcaccaccaacagcgagagc ctggaggaggccggctcggcgcacagcgatgagcagagcagcggcaccctgagctctccg ggccagtcggacatcctgctgaccgccgcacagggcacggtgcgcaaggccggcgccctg gccgtcaagaacttcctggtgcacaagaagaacaagaaggtggagtcagccacccggagg aagtggaagcactactgggtgtccctgaaaggatgcacgctatttttctacgagagcgac ggcaggtctgggatagaccacaacagcatccccaaacacgccgtctgggtggagaacagc attgtgcaggcggtgcctgagcaccccaagaaggactttgtcttctgcctcagcaattcc ctgggtgatgccttcctttttcagaccactagccagacggagcttgaaaactggatcacc gccatccactctgcctgcgccactgcggtcgcgaggcaccaccacaaggaagacacgctc cgactcctgaaatcagagatcaaaaaactggaacagaagattgacatggatgaaaagatg aagaaaatgggtgaaatgcagctgtcttcagtcactgactcaaagaaaaagaaaacaata ttagatcagatctttgtctgggagcaaaatctcgagcagttccaaatggacctgtttcgt ttccgctgttatttagccagccttcagggtggggagctgccaaaccccaaaaggcttctc gcttttgcaagtcgaccaacgaaagtggccatgggccgccttggaatcttttcggtatca tcgtttcatgccctggtggcagcacgcactggtgaaactggagtgagaagacgtactcag gccatgtccagatccgcgagcaagcgaaggagcaggttttcttctctgtggggtctggat actacctccaaaaagaagcagggacggccaagcatcaatcaggtgtttggagagggaacc gaagctgtaaagaaatctttagagggaatatttgatgacattgttccagatggcaagagg gagaaagaagtggtcttacctaacgttcaccagcacaaccctgactgcgacatttgggtc cacgagtatttcactccatcctggttctgtctgcccaataatcagcctgccctgacggtc gtccggccaggcgacactgcacgggacaccctggagctgatttgcaagacacatcaactg gatcattctgctcattacctgcgcctgaaatttctaatagaaaacaaaatgcagctctat gttccacagcccgaggaagacatctatgagctgctgtacaaagaaattgaaatctgtcca aaagtcactcagagcatccacattgagaagtcagatacagctgctgatacttacgggttt tcactttcttctgtggaagaagatggtattcgaaggctgtacgtgaatagtgtgaaggaa accggtttagcttccaagaaaggcctgaaagcaggagatgagattcttgagatcaataat cgtgctgctgacgccctgaactcttctatgctcaaagatttcctctcacagccctcgctg ggcctcctggtgaggacctaccccgagctggaggaaggagtggagctgctggaaagcccg ccccaccgagtggacggccctgccgaccttggcgagagccccctcgcctttctcaccagc aacccagggcacagcctttgcagcgagcagggcagcagtgctgagaccgctccagaggag accgaggggccagacttggaatcctcagatgagactgatcacagcagcaagagtacagaa caggtggccgcattttgccgcagtttgcatgagatgaacccctctgaccagagcccatct cctcaggactccacggggcctcagctggcgaccatgagacaactctcggatgcagataag ctgcgcaaggtgatctgcgagctcctggagacggagcgcacctacgtgaaggatttaaac tgtcttatggagagatacctaaagcctcttcaaaaagaaacttttctcacccaggatgag cttgacgtgctttttggaaatttaacggaaatggtagagtttcaagtagaattccttaaa actctagaagatggagtgagactggtacctgatttggaaaagcttgagaaggttgatcaa tttaagaaagtgctgttctctctggggggatcattcctgtattatgctgaccgcttcaag ctctacagtgccttctgcgccagccacacaaaagttcccaaggtcctggtgaaagccaag acagacacggctttcaaggcattcttggatgcccagaacccgaagcagcagcactcatcc acgctggagtcgtacctcatcaagcccatccagaggatcctcaagtacccacttctgctc agggagctgttcgccctgaccgatgcggagagcgaggagcactaccacctggacgtggcc atcaagaccatgaacaaggttgccagtcacatcaatgagatgcagaaaatccatgaagag tttggggctgtgtttgaccagctgattgctgaacagactggtgagaaaaaagaggttgca gatctgagcatgggagacctgcttttgcacactaccgtgatctggctgaacccgccggcc tcgctgggcaagtggaaaaaggaaccagagttggcagcattcgtcttcaaaactgctgtg gtccttgtgtataaagatggttccaaacagaagaagaaacttgtaggatctcacaggctt tccatttatgaggactgggaccccttcagatttcgacacatgatccccacggaagcgctg caggttcgagctttggcgagtgcagatgcagaggcaaatgccgtgtgtgaaattgtccat gtaaaatccgagtctgaagggaggccggagagggtctttcacttgtgctgcagctcccca gagagccgaaaggatttcctaaaggctgtgcattcaatcctgcgtgataagcacagaaga cagctcctcaaaaccgagagccttccctcatcccagcaatatgtcccttttggaggcaaa agattgtgtgcactgaagggggccaggccggccatgagcagggcagtgtctgccccaagc aagtctcttgggaggaggaggcggcggctggctcgaaacaggtttaccattgattctgat gccgtctccgcaagcagcccggagaaagagtcccagcagccccccggtggtggggacact gaccgatgggtagaggagcagtttgatcttgctcagtatgaggagcaagatgacatcaag gagacagacatcctcagtgacgatgatgagttctgtgagtccgtgaagggtgcctcagtg gacagagacctgcaggagcggcttcaggccacctccatcagtcagcgggaaagaggccgg aaaaccctggatagtcacgcgtcccgcatggcacagctcaagaagcaagctgccctgtcg gggatcaatggaggcctggagagcgcaagcgaggaagtcatttgggttaggcgtgaagac tttgccccctccaggaaactgaacactgagatctga

Homo sapiens (human): 7409 Help Entry 7409              CDS       T01001                                  Symbol VAV1, VAV Name (RefSeq) vav guanine nucleotide exchange factor 1   KO K05730   guanine nucleotide exchange factor VAV Organism hsa  Homo sapiens (human) Pathway hsa04015   Rap1 signaling pathway hsa04024   cAMP signaling pathway hsa04062   Chemokine signaling pathway hsa04510   Focal adhesion hsa04650   Natural killer cell mediated cytotoxicity hsa04660   T cell receptor signaling pathway hsa04662   B cell receptor signaling pathway hsa04664   Fc epsilon RI signaling pathway hsa04666   Fc gamma R-mediated phagocytosis hsa04670   Leukocyte transendothelial migration hsa04810   Regulation of actin cytoskeleton hsa05135   Yersinia infection hsa05205   Proteoglycans in cancer hsa05417   Lipid and atherosclerosis Network nt06183  Yersinia nt06537  TCR/BCR signaling   Element N01106   TCR-PLCG-ITPR signaling pathway N01108   Yersinia YopH to TCR-NFAT signaling pathway Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     7409 (VAV1)    04024 cAMP signaling pathway     7409 (VAV1)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     7409 (VAV1)   09142 Cell motility    04810 Regulation of actin cytoskeleton     7409 (VAV1)  09150 Organismal Systems   09151 Immune system    04650 Natural killer cell mediated cytotoxicity     7409 (VAV1)    04660 T cell receptor signaling pathway     7409 (VAV1)    04662 B cell receptor signaling pathway     7409 (VAV1)    04664 Fc epsilon RI signaling pathway     7409 (VAV1)    04666 Fc gamma R-mediated phagocytosis     7409 (VAV1)    04670 Leukocyte transendothelial migration     7409 (VAV1)    04062 Chemokine signaling pathway     7409 (VAV1)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     7409 (VAV1)   09171 Infectious disease: bacterial    05135 Yersinia infection     7409 (VAV1)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     7409 (VAV1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RhoGEF SH3_1 SH3_2 CAMSAP_CH CH SH2 SH3_9 C1_1 PH CDC24 C1_2 LZ3wCH Motif Other DBs NCBI-GeneID:  7409 NCBI-ProteinID:  NP_005419 OMIM:  164875 HGNC:  12657 Ensembl:  ENSG00000141968 UniProt:  P15498 Q96D37 B2R8B5 Structure PDB LinkDB All DBs Position 19:6772708..6857361 Genome browser AA seq 845 aa AA seqDB search MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREV NLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPI AQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRS EPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINI EDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLAL DAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKM DRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGAQ GYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTF YQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVH GPPQDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKI MTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGS TKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEED YSEYC NT seq 2538 nt NT seq  +upstreamnt  +downstreamnt atggagctgtggcgccaatgcacccactggctcatccagtgccgggtgctgccgcccagc caccgcgtgacctgggatggggctcaggtgtgtgaactggcccaggccctccgggatggt gtccttctgtgtcagctgcttaacaacctgctaccccatgccatcaacctgcgtgaggtc aacctgcgcccccagatgtcccagttcctgtgccttaagaacattagaaccttcctgtcc acctgctgtgagaagttcggcctcaagcggagcgagctcttcgaagcctttgacctcttc gatgtgcaggattttggcaaggtcatctacaccctgtctgctctgtcctggaccccgatc gcccagaacagggggatcatgcccttccccaccgaggaggagagtgtaggtgatgaagac atctacagtggcctgtccgaccagatcgacgacacggtggaggaggatgaggacctgtat gactgcgtggagaatgaggaggcggaaggcgacgagatctatgaggacctcatgcgctcg gagcccgtgtccatgccgcccaagatgacagagtatgacaagcgctgctgctgcctgcgg gagatccagcagacggaggagaagtacactgacacgctgggctccatccagcagcatttc ttgaagcccctgcaacggttcctgaaacctcaagacattgagatcatctttatcaacatt gaggacctgcttcgtgttcatactcacttcctaaaggagatgaaggaagccctgggcacc cctggcgcagccaatctctaccaggtcttcatcaaatacaaggagaggttcctcgtctat ggccgctactgcagccaggtggagtcagccagcaaacacctggaccgtgtggccgcagcc cgggaggacgtgcagatgaagctggaggaatgttctcagagagccaacaacgggaggttc accctgcgggacctgctgatggtgcctatgcagcgagttctcaaatatcacctccttctc caggagctggtgaaacacacgcaggaggcgatggagaaggagaacctgcggctggccctg gatgccatgagggacctggctcagtgcgtgaacgaggtcaagcgagacaacgagacactg cgacagatcaccaatttccagctgtccattgagaacctggaccagtctctggctcactat ggccggcccaagatcgacggggaactcaagatcacctcggtggaacggcgctccaagatg gacaggtatgccttcctgctcgacaaagctctactcatctgtaagcgcaggggagactcc tatgacctcaaggactttgtaaacctgcacagcttccaggttcgggatgactcttcagga gaccgagacaacaagaagtggagccacatgttcctcctgatcgaggaccaaggtgcccag ggctatgagctgttcttcaagacaagagaattgaagaagaagtggatggagcagtttgag atggccatctccaacatctatccggagaatgccaccgccaacgggcatgacttccagatg ttctcctttgaggagaccacatcctgcaaggcctgtcagatgctgcttagaggtaccttc tatcagggctaccgctgccatcggtgccgggcatctgcacacaaggagtgtctggggagg gtccctccatgtggccgacatgggcaagatttcccaggaactatgaagaaggacaaacta catcgcagggctcaggacaaaaagaggaatgagctgggtctgcccaagatggaggtgttt caggaatactacgggcttcctccaccccctggagccattggaccctttctacggctcaac cctggagacattgtggagctcacgaaggctgaggctgaacagaactggtgggagggcaga aatacatctactaatgaaattggctggtttccttgtaacagggtgaagccctatgtccat ggccctcctcaggacctgtctgttcatctctggtacgcaggccccatggagcgggcaggg gcagagagcatcctggccaaccgctcggacgggactttcttggtgcggcagagggtgaag gatgcagcagaatttgccatcagcattaaatataacgtcgaggtcaagcacattaaaatc atgacagcagaaggactgtaccggatcacagagaaaaaggctttccgggggcttacggag ctggtggagttttaccagcagaactctctaaaggattgcttcaagtctctggacaccacc ttgcagttccccttcaaggagcctgaaaagagaaccatcagcaggccagcagtgggaagc acaaagtattttggcacagccaaagcccgctatgacttctgcgcccgagaccgatcagag ctgtcgctcaaggagggtgacatcatcaagatccttaacaagaagggacagcaaggctgg tggcgaggggagatctatggccgggttggctggttccctgccaactacgtggaggaagat tattctgaatactgctga

Homo sapiens (human): 7410 Help Entry 7410              CDS       T01001                                  Symbol VAV2, VAV-2 Name (RefSeq) vav guanine nucleotide exchange factor 2   KO K05730   guanine nucleotide exchange factor VAV Organism hsa  Homo sapiens (human) Pathway hsa04015   Rap1 signaling pathway hsa04024   cAMP signaling pathway hsa04062   Chemokine signaling pathway hsa04510   Focal adhesion hsa04650   Natural killer cell mediated cytotoxicity hsa04660   T cell receptor signaling pathway hsa04662   B cell receptor signaling pathway hsa04664   Fc epsilon RI signaling pathway hsa04666   Fc gamma R-mediated phagocytosis hsa04670   Leukocyte transendothelial migration hsa04810   Regulation of actin cytoskeleton hsa05135   Yersinia infection hsa05205   Proteoglycans in cancer hsa05417   Lipid and atherosclerosis Network nt06183  Yersinia nt06537  TCR/BCR signaling   Element N01106   TCR-PLCG-ITPR signaling pathway N01108   Yersinia YopH to TCR-NFAT signaling pathway Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     7410 (VAV2)    04024 cAMP signaling pathway     7410 (VAV2)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     7410 (VAV2)   09142 Cell motility    04810 Regulation of actin cytoskeleton     7410 (VAV2)  09150 Organismal Systems   09151 Immune system    04650 Natural killer cell mediated cytotoxicity     7410 (VAV2)    04660 T cell receptor signaling pathway     7410 (VAV2)    04662 B cell receptor signaling pathway     7410 (VAV2)    04664 Fc epsilon RI signaling pathway     7410 (VAV2)    04666 Fc gamma R-mediated phagocytosis     7410 (VAV2)    04670 Leukocyte transendothelial migration     7410 (VAV2)    04062 Chemokine signaling pathway     7410 (VAV2)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     7410 (VAV2)   09171 Infectious disease: bacterial    05135 Yersinia infection     7410 (VAV2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     7410 (VAV2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RhoGEF CAMSAP_CH SH3_2 CH SH3_1 SH3_9 SH2 PH C1_1 C1_2 PLU-1 CDC24 SH2_2 PH_10 zf-RING-like zf-RING_16 Motif Other DBs NCBI-GeneID:  7410 NCBI-ProteinID:  NP_001127870 OMIM:  600428 HGNC:  12658 Ensembl:  ENSG00000160293 UniProt:  P52735 Structure PDB LinkDB All DBs Position 9:complement(133761894..133992324) Genome browser AA seq 878 aa AA seqDB search MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV QQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAV FINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQL LASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLK EALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNH TKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMWSYGFY LIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKAC KMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGN PAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISR PPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHI KVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSR SPASCASYNFSFLSPQGLSFASQGPSAPFWSVFTPRVIGTAVARYNFAARDMRELSLREG DVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGIQ NT seq 2637 nt NT seq  +upstreamnt  +downstreamnt atggagcagtggcggcagtgcggccgctggctcatcgattgcaaggtcctgccgcccaac caccgggtggtgtggccctcggccgtggtcttcgacctggcgcaggcgctgcgcgacggg gtccttctgtgccagctgctgcacaacctctcccccggctccatcgacctcaaggacatc aacttccggccgcagatgtcccagtttctgtgtttgaagaacatacgcaccttcctgaaa gtctgccacgataaatttggattaaggaacagcgagctgtttgacccctttgacctcttc gatgtgcgagactttggaaaggtcatctccgcggtgtcgaggctctccctgcacagcatc gcgcagaacaaagggatcaggccttttccctcagaggagaccacagagaatgacgatgac gtctaccgcagcctggaggagctggccgacgagcatgacctgggggaggacatctacgac tgcgtcccgtgtgaggatggaggggacgacatctacgaggacatcatcaaggtggaggtg cagcagcccatgattagatacatgcagaaaatgggcatgactgaagatgacaagaggaac tgctgcctgctggagatccaggagaccgaggccaagtactaccgcaccctggaggacatt gagaagaactacatgagccccctgcggctggtgctgagcccggcggacatggcagctgtc ttcattaacctggaggacctgatcaaggtgcatcacagcttcctgagggccatcgacgtg tccgtgatggtggggggcagcacgctggccaaggtcttcctcgatttcaaggaaaggctt ctgatctacggggagtactgcagccacatggagcacgcccagaacacactgaaccagctc ctggccagccgggaggacttcaggcagaaagtcgaggagtgcacactgaaggtccaggat ggaaaatttaagctgcaagacctgctggtggtccccatgcagagggtgctcaaataccac ctgctcttgaaggagcttctgagccattctgcggaacggcctgagaggcagcagctcaaa gaagcactggaagccatgcaggacttggcgatgtacatcaatgaagttaaacgggacaag gagaccttgaggaaaatcagcgaatttcagagttctatagaaaatttgcaagtgaaactg gaggaatttggaagaccaaagattgacggggaactgaaagtccggtccatagtcaaccac accaagcaggacaggtacttgttcctgtttgacaaggtggtcatcgtctgcaagcggaag ggctacagctacgagctcaaggagatcatcgagctgctgttccacaagatgaccgacgac cccatgaacaacaaggacgtcaagaagtctcacgggaaaatgtggtcctacggcttctac ctaattcaccttcaaggaaagcagggcttccagtttttctgcaaaacagaagatatgaag aggaagtggatggagcagtttgagatggccatgtcaaacatcaagccagacaaagccaat gccaaccaccacagtttccagatgtacacgtttgacaagaccaccaactgcaaagcctgc aaaatgttcctcaggggcaccttctaccagggatacatgtgtaccaagtgtggcgtcggg gcacacaaggagtgcctggaagtgatacctccctgcaagttcacttctcctgcagatctg gacgcctccggagcgggaccaggtcccaagatggtggccatgcagaattaccatggcaac ccagcccctcccgggaagcctgtgctgaccttccagacgggcgacgtgcttgagctgctg aggggcgaccctgagtctccgtggtgggagggtcgtctggtacaaaccaggaagtcaggg tatttccccagctcatctgtgaagccctgccctgtggatggaaggccgcccatcagccgg ccgccatcccgggagatcgactacactgcatacccctggtttgcaggtaacatggagagg cagcagacggacaacctgctcaagtcccacgccagcgggacctacctgatcagggagcgg cctgccgaggctgagcgctttgcaataagcatcaagttcaatgatgaggtgaagcacatc aaggtggtggagaaggacaactggatccacatcacagaggccaagaaattcgacagcctc ctggagttggtggagtactaccagtgccactcactgaaggagagcttcaagcagctggac accacactcaagtacccctacaagtcccgggaacgttcggcctccagggcctccagccgg tccccagcttcctgtgcttcctacaacttttcttttctcagtcctcagggcctcagcttt gcttctcagggcccctccgctcccttctggtcagtgttcacgccccgcgtcatcggcaca gctgtggccaggtataactttgccgcccgagatatgagggagctttcgctgcgggagggt gacgtggtgaggatctacagccgcatcggcggagaccagggctggtggaagggcgagacc aacggacggattggctggtttccttcaacgtacgtagaagaggagggcatccagtga

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