Homo sapiens (human): 1056 Help Entry 1056              CDS       T01001                                  Gene name CEL, BAL, BSDL, BSSL, CELL, CEase, FAP, FAPP, LIPA, MODY8 Definition (RefSeq) carboxyl ester lipase   KO K12298   bile salt-stimulated lipase [EC:3.1.1.3 3.1.1.13] Organism hsa  Homo sapiens (human) Pathway hsa00100   Steroid biosynthesis hsa00561   Glycerolipid metabolism hsa01100   Metabolic pathways hsa04972   Pancreatic secretion hsa04975   Fat digestion and absorption Module hsa_M00098   Acylglycerol degradation Disease H00410   Maturity onset diabetes of the young (MODY) Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09103 Lipid metabolism    00100 Steroid biosynthesis     1056 (CEL)    00561 Glycerolipid metabolism     1056 (CEL)  09150 Organismal Systems   09154 Digestive system    04972 Pancreatic secretion     1056 (CEL)    04975 Fat digestion and absorption     1056 (CEL)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:hsa04147]     1056 (CEL) Enzymes [BR:hsa01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.1  Carboxylic-ester hydrolases     3.1.1.3  triacylglycerol lipase      1056 (CEL)     3.1.1.13  sterol esterase      1056 (CEL) Exosome [BR:hsa04147]  Exosomal proteins   Exosomal proteins of breast milk    1056 (CEL) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  COesterase Mucin-like Abhydrolase_3 Say1_Mug180 Motif Other DBs NCBI-GeneID:  1056 NCBI-ProteinID:  NP_001798 OMIM:  114840 HGNC:  1848 Ensembl:  ENSG00000170835 Vega:  OTTHUMG00000020855 UniProt:  O75612 B4DSX9 Q86SR3 LinkDB All DBs Structure PDB:  6H1A 6H18 6H19 6H0T 6H0V 1F6W 1JMY Thumbnails Position 9q34.13 AA seq 753 aa AA seqDB search MGRLQLVVLGLTCCWAVASAAKLGAVYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTK ALENPQPHPGWQGTLKAKNFKKRCLQATITQDSTYGDEDCLYLNIWVPQGRKQVSRDLPV MIWIYGGAFLMGSGHGANFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPG NYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQS GVALSPWVIQKNPLFWAKKVAEKVGCPVGDAARMAQCLKVTDPRALTLAYKVPLAGLEYP MLHYVGFVPVIDGDFIPADPINLYANAADIDYIAGTNNMDGHIFASIDMPAINKGNKKVT EEDFYKLVSEFTITKGLRGAKTTFDVYTESWAQDPSQENKKKTVVDFETDVLFLVPTEIA LAQHRANAKSAKTYAYLFSHPSRMPVYPKWVGADHADDIQYVFGKPFATPTGYRPQDRTV SKAMIAYWTNFAKTGDPNMGDSAVPTHWEPYTTENSGYLEITKKMGSSSMKRSLRTNFLR YWTLTYLALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSG APPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVP PTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDS GAPPVPPTGDSEAAPVPPTDDSKEAQMPAVIRF NT seq 2262 nt NT seq  +upstreamnt  +downstreamnt atggggcgcctgcaactggttgtgttgggcctcacctgctgctgggcagtggcgagtgcc gcgaagctgggcgccgtgtacacagaaggtgggttcgtggaaggcgtcaataagaagctc ggcctcctgggtgactctgtggacatcttcaagggcatccccttcgcagctcccaccaag gccctggaaaatcctcagccacatcctggctggcaagggaccctgaaggccaagaacttc aagaagagatgcctgcaggccaccatcacccaggacagcacctacggggatgaagactgc ctgtacctcaacatttgggtgccccagggcaggaagcaagtctcccgggacctgcccgtt atgatctggatctatggaggcgccttcctcatggggtccggccatggggccaacttcctc aacaactacctgtatgacggcgaggagatcgccacacgcggaaacgtcatcgtggtcacc ttcaactaccgtgtcggcccccttgggttcctcagcactggggacgccaatctgccaggt aactatggccttcgggatcagcacatggccattgcttgggtgaagaggaatatcgcggcc ttcgggggggaccccaacaacatcacgctcttcggggagtctgctggaggtgccagcgtc tctctgcagaccctctccccctacaacaagggcctcatccggcgagccatcagccagagc ggcgtggccctgagtccctgggtcatccagaaaaacccactcttctgggccaaaaaggtg gctgagaaggtgggttgccctgtgggtgatgccgccaggatggcccagtgtctgaaggtt actgatccccgagccctgacgctggcctataaggtgccgctggcaggcctggagtacccc atgctgcactatgtgggcttcgtccctgtcattgatggagacttcatccccgctgacccg atcaacctgtacgccaacgccgccgacatcgactatatagcaggcaccaacaacatggac ggccacatcttcgccagcatcgacatgcctgccatcaacaagggcaacaagaaagtcacg gaggaggacttctacaagctggtcagtgagttcacaatcaccaaggggctcagaggcgcc aagacgacctttgatgtctacaccgagtcctgggcccaggacccatcccaggagaataag aagaagactgtggtggactttgagaccgatgtcctcttcctggtgcccaccgagattgcc ctagcccagcacagagccaatgccaagagtgccaagacctacgcctacctgttttcccat ccctctcggatgcccgtctaccccaaatgggtgggggccgaccatgcagatgacattcag tacgttttcgggaagcccttcgccacccccacgggctaccggccccaagacaggacagtc tctaaggccatgatcgcctactggaccaactttgccaaaacaggggaccccaacatgggc gactcggctgtgcccacacactgggaaccctacactacggaaaacagcggctacctggag atcaccaagaagatgggcagcagctccatgaagcggagcctgagaaccaacttcctgcgc tactggaccctcacctatctggcgctgcccacagtgaccgaccaggaggccacccctgtg ccccccacaggggactccgaggccactcccgtgccccccacgggtgactccgagaccgcc cccgtgccgcccacgggtgactccggggccccccccgtgccgcccacgggtgactccggg gccccccccgtgccgcccacgggtgactccggggccccccccgtgccgcccacgggtgac tccggggccccccccgtgccgcccacgggtgactccggggccccccccgtgccgcccacg ggtgactccggggccccccccgtgccgcccacgggtgactccggggccccccccgtgccg cccacgggtgactccggcgccccccccgtgccgcccacgggtgacgccgggccccccccc gtgccgcccacgggtgactccggcgccccccccgtgccgcccacgggtgactccggggcc ccccccgtgacccccacgggtgactccgagaccgcccccgtgccgcccacgggtgactcc ggggccccccctgtgccccccacgggtgactctgaggctgcccctgtgccccccacagat gactccaaggaagctcagatgcctgcagtcattaggttttag

Homo sapiens (human): 26279 Help Entry 26279             CDS       T01001                                  Gene name PLA2G2D, PLA2IID, SPLASH, sPLA2-IID, sPLA2S Definition (RefSeq) phospholipase A2 group IID   KO K01047   secretory phospholipase A2 [EC:3.1.1.4] Organism hsa  Homo sapiens (human) Pathway hsa00564   Glycerophospholipid metabolism hsa00565   Ether lipid metabolism hsa00590   Arachidonic acid metabolism hsa00591   Linoleic acid metabolism hsa00592   alpha-Linolenic acid metabolism hsa01100   Metabolic pathways hsa04014   Ras signaling pathway hsa04270   Vascular smooth muscle contraction hsa04972   Pancreatic secretion hsa04975   Fat digestion and absorption Drug target Varespladib (DG01394):  D06283 Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09103 Lipid metabolism    00564 Glycerophospholipid metabolism     26279 (PLA2G2D)    00565 Ether lipid metabolism     26279 (PLA2G2D)    00590 Arachidonic acid metabolism     26279 (PLA2G2D)    00591 Linoleic acid metabolism     26279 (PLA2G2D)    00592 alpha-Linolenic acid metabolism     26279 (PLA2G2D)  09130 Environmental Information Processing   09132 Signal transduction    04014 Ras signaling pathway     26279 (PLA2G2D)  09150 Organismal Systems   09153 Circulatory system    04270 Vascular smooth muscle contraction     26279 (PLA2G2D)   09154 Digestive system    04972 Pancreatic secretion     26279 (PLA2G2D)    04975 Fat digestion and absorption     26279 (PLA2G2D)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:hsa03036]     26279 (PLA2G2D) Enzymes [BR:hsa01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.1  Carboxylic-ester hydrolases     3.1.1.4  phospholipase A2      26279 (PLA2G2D) Chromosome and associated proteins [BR:hsa03036]  Eukaryotic type   Centrosome formation and ciliogenesis proteins    Centriole proteins     26279 (PLA2G2D) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Phospholip_A2_1 Parvo_coat_N DUF5460 Motif Other DBs NCBI-GeneID:  26279 NCBI-ProteinID:  NP_036532 OMIM:  605630 HGNC:  9033 Ensembl:  ENSG00000117215 Vega:  OTTHUMG00000002701 Pharos:  Q9UNK4(Tchem) UniProt:  Q9UNK4 LinkDB All DBs Position 1p36.12 AA seq 145 aa AA seqDB search MELALLCGLVVMAGVIPIQGGILNLNKMVKQVTGKMPILSYWPYGCHCGLGGRGQPKDAT DWCCQTHDCCYDHLKTQGCSIYKDYYRYNFSQGNIHCSDKGSWCEQQLCACDKEVAFCLK RNLDTYQKRLRFYWRPHCRGQTPGC NT seq 438 nt NT seq  +upstreamnt  +downstreamnt atggaacttgcactgctgtgtgggctggtggtgatggctggtgtgattccaatccagggc gggatcctgaacctgaacaagatggtcaagcaagtgactgggaaaatgcccatcctctcc tactggccctacggctgtcactgcggactaggtggcagaggccaacccaaagatgccacg gactggtgctgccagacccatgactgctgctatgaccacctgaagacccaggggtgcagc atctacaaggactattacagatacaacttttcccaggggaacatccactgctctgacaag ggaagctggtgtgagcagcagctgtgtgcctgtgacaaggaggtggccttctgcctgaag cgcaacctggacacctaccagaagcgactgcgtttctactggcggccccactgccggggg cagacccctgggtgctag

Homo sapiens (human): 30814 Help Entry 30814             CDS       T01001                                  Gene name PLA2G2E, GIIE_sPLA2, sPLA2-IIE Definition (RefSeq) phospholipase A2 group IIE   KO K01047   secretory phospholipase A2 [EC:3.1.1.4] Organism hsa  Homo sapiens (human) Pathway hsa00564   Glycerophospholipid metabolism hsa00565   Ether lipid metabolism hsa00590   Arachidonic acid metabolism hsa00591   Linoleic acid metabolism hsa00592   alpha-Linolenic acid metabolism hsa01100   Metabolic pathways hsa04014   Ras signaling pathway hsa04270   Vascular smooth muscle contraction hsa04972   Pancreatic secretion hsa04975   Fat digestion and absorption Drug target Varespladib (DG01394):  D06283 Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09103 Lipid metabolism    00564 Glycerophospholipid metabolism     30814 (PLA2G2E)    00565 Ether lipid metabolism     30814 (PLA2G2E)    00590 Arachidonic acid metabolism     30814 (PLA2G2E)    00591 Linoleic acid metabolism     30814 (PLA2G2E)    00592 alpha-Linolenic acid metabolism     30814 (PLA2G2E)  09130 Environmental Information Processing   09132 Signal transduction    04014 Ras signaling pathway     30814 (PLA2G2E)  09150 Organismal Systems   09153 Circulatory system    04270 Vascular smooth muscle contraction     30814 (PLA2G2E)   09154 Digestive system    04972 Pancreatic secretion     30814 (PLA2G2E)    04975 Fat digestion and absorption     30814 (PLA2G2E)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:hsa03036]     30814 (PLA2G2E) Enzymes [BR:hsa01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.1  Carboxylic-ester hydrolases     3.1.1.4  phospholipase A2      30814 (PLA2G2E) Chromosome and associated proteins [BR:hsa03036]  Eukaryotic type   Centrosome formation and ciliogenesis proteins    Centriole proteins     30814 (PLA2G2E) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Phospholip_A2_1 Motif Other DBs NCBI-GeneID:  30814 NCBI-ProteinID:  NP_055404 OMIM:  618320 HGNC:  13414 Ensembl:  ENSG00000188784 Vega:  OTTHUMG00000002702 Pharos:  Q9NZK7(Tchem) UniProt:  Q9NZK7 LinkDB All DBs Structure PDB:  5Y5E 5WZO 5WZW 5WZM 5WZU 5WZV 5WZS 5WZT Thumbnails Position 1p36.13 AA seq 142 aa AA seqDB search MKSPHVLVFLCLLVALVTGNLVQFGVMIEKMTGKSALQYNDYGCYCGIGGSHWPVDQTDW CCHAHDCCYGRLEKLGCEPKLEKYLFSVSERGIFCAGRTTCQRLTCECDKRAALCFRRNL GTYNRKYAHYPNKLCTGPTPPC NT seq 429 nt NT seq  +upstreamnt  +downstreamnt atgaaatctccccacgtgctggtgttcctttgcctcctggtggctctggtcaccgggaac ctggttcagtttggggtgatgatcgagaagatgacaggcaagtccgccctgcagtacaac gactatggctgttactgcggcatcggtggctcccactggccggtggaccagactgactgg tgctgccacgcccacgactgctgctacgggcgtctggagaagctgggctgtgagcccaaa ctggaaaagtatcttttctctgtcagcgaacgtggcattttctgcgccggcaggaccacc tgccagcggctgacctgcgagtgtgacaagagggctgccctctgctttcgccgcaacctg ggcacctacaaccgcaaatatgcccattatcccaacaagctgtgcaccgggcccaccccg ccctgctga

Homo sapiens (human): 391013 Help Entry 391013            CDS       T01001                                  Gene name PLA2G2C, UBXN10-AS1 Definition (RefSeq) phospholipase A2 group IIC   KO K01047   secretory phospholipase A2 [EC:3.1.1.4] Organism hsa  Homo sapiens (human) Pathway hsa00564   Glycerophospholipid metabolism hsa00565   Ether lipid metabolism hsa00590   Arachidonic acid metabolism hsa00591   Linoleic acid metabolism hsa00592   alpha-Linolenic acid metabolism hsa01100   Metabolic pathways hsa04014   Ras signaling pathway hsa04270   Vascular smooth muscle contraction hsa04972   Pancreatic secretion hsa04975   Fat digestion and absorption Drug target Varespladib (DG01394):  D06283 Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09103 Lipid metabolism    00564 Glycerophospholipid metabolism     391013 (PLA2G2C)    00565 Ether lipid metabolism     391013 (PLA2G2C)    00590 Arachidonic acid metabolism     391013 (PLA2G2C)    00591 Linoleic acid metabolism     391013 (PLA2G2C)    00592 alpha-Linolenic acid metabolism     391013 (PLA2G2C)  09130 Environmental Information Processing   09132 Signal transduction    04014 Ras signaling pathway     391013 (PLA2G2C)  09150 Organismal Systems   09153 Circulatory system    04270 Vascular smooth muscle contraction     391013 (PLA2G2C)   09154 Digestive system    04972 Pancreatic secretion     391013 (PLA2G2C)    04975 Fat digestion and absorption     391013 (PLA2G2C)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:hsa03036]     391013 (PLA2G2C) Enzymes [BR:hsa01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.1  Carboxylic-ester hydrolases     3.1.1.4  phospholipase A2      391013 (PLA2G2C) Chromosome and associated proteins [BR:hsa03036]  Eukaryotic type   Centrosome formation and ciliogenesis proteins    Centriole proteins     391013 (PLA2G2C) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Phospholip_A2_1 Motif Other DBs NCBI-GeneID:  391013 NCBI-ProteinID:  NP_001303651 HGNC:  9032 Ensembl:  ENSG00000187980 Vega:  OTTHUMG00000002705 LinkDB All DBs Position 1p36.12 AA seq 150 aa AA seqDB search MKVIAILTLLLFCSPTHSSFWQFQRRVKHITGRSAFFSYYGYGCYCGLGDKGIPVDDTDS PSSPSPYEKLKEFSCQPVLNSYQFHIVNGAVVCGCTLGPGASCHCRLKACECDKQSVHCF KESLPTYEKNFKQFSSQPRTAAPTLQKSLG NT seq 453 nt NT seq  +upstreamnt  +downstreamnt atgaaggtcattgccatcctcaccctcctcctcttctgctcccccacccacagcagtttc tggcagtttcagaggagggtcaaacacatcacggggcgaagtgccttcttctcatattac ggatatggctgctactgtgggcttggggataaagggatccccgtggatgacactgacagc ccctcatctccctctccctacgagaagctgaaggagttcagctgccagcctgtgttgaac agctaccagttccacatcgtcaatggcgcagtggtttgtggatgcacccttggtcctggt gccagctgccactgcaggctgaaggcctgtgagtgtgacaagcaatccgtgcactgcttc aaagagagcctgcccacctatgagaaaaacttcaagcagttctccagccagcccaggaca gctgcccccaccctgcaaaaaagcctgggctag

Homo sapiens (human): 50487 Help Entry 50487             CDS       T01001                                  Gene name PLA2G3, GIII-SPLA2, SPLA2III, sPLA2-III Definition (RefSeq) phospholipase A2 group III   KO K01047   secretory phospholipase A2 [EC:3.1.1.4] Organism hsa  Homo sapiens (human) Pathway hsa00564   Glycerophospholipid metabolism hsa00565   Ether lipid metabolism hsa00590   Arachidonic acid metabolism hsa00591   Linoleic acid metabolism hsa00592   alpha-Linolenic acid metabolism hsa01100   Metabolic pathways hsa04014   Ras signaling pathway hsa04270   Vascular smooth muscle contraction hsa04972   Pancreatic secretion hsa04975   Fat digestion and absorption Drug target Varespladib (DG01394):  D06283 Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09103 Lipid metabolism    00564 Glycerophospholipid metabolism     50487 (PLA2G3)    00565 Ether lipid metabolism     50487 (PLA2G3)    00590 Arachidonic acid metabolism     50487 (PLA2G3)    00591 Linoleic acid metabolism     50487 (PLA2G3)    00592 alpha-Linolenic acid metabolism     50487 (PLA2G3)  09130 Environmental Information Processing   09132 Signal transduction    04014 Ras signaling pathway     50487 (PLA2G3)  09150 Organismal Systems   09153 Circulatory system    04270 Vascular smooth muscle contraction     50487 (PLA2G3)   09154 Digestive system    04972 Pancreatic secretion     50487 (PLA2G3)    04975 Fat digestion and absorption     50487 (PLA2G3)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:hsa03036]     50487 (PLA2G3) Enzymes [BR:hsa01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.1  Carboxylic-ester hydrolases     3.1.1.4  phospholipase A2      50487 (PLA2G3) Chromosome and associated proteins [BR:hsa03036]  Eukaryotic type   Centrosome formation and ciliogenesis proteins    Centriole proteins     50487 (PLA2G3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Phospholip_A2_2 Chromadorea_ALT Motif Other DBs NCBI-GeneID:  50487 NCBI-ProteinID:  NP_056530 OMIM:  611651 HGNC:  17934 Ensembl:  ENSG00000100078 Vega:  OTTHUMG00000151255 Pharos:  Q9NZ20(Tbio) UniProt:  Q9NZ20 LinkDB All DBs Position 22q12.2 AA seq 509 aa AA seqDB search MGVQAGLFGMLGFLGVALGGSPALRWYRTSCHLTKAVPGNPLGYLSFLAKDAQGLALIHA RWDAHRRLQSCSWEDEPELTAAYGALCAHETAWGSFIHTPGPELQRALATLQSQWEACRA LEESPAGARKKRAAGQSGVPGGGHQREKRGWTMPGTLWCGVGDSAGNSSELGVFQGPDLC CREHDRCPQNISPLQYNYGIRNYRFHTISHCDCDTRFQQCLQNQHDSISDIVGVAFFNVL EIPCFVLEEQEACVAWYWWGGCRMYGTVPLARLQPRTFYNASWSSRATSPTPSSRSPAPP KPRQKQHLRKGPPHQKGSKRPSKANTTALQDPMVSPRLDVAPTGLQGPQGGLKPQGARWV CRSFRRHLDQCEHQIGPREIEFQLLNSAQEPLFHCNCTRRLARFLRLHSPPEVTNMLWEL LGTTCFKLAPPLDCVEGKNCSRDPRAIRVSARHLRRLQQRRHQLQDKGTDERQPWPSEPL RGPMSFYNQCLQLTQAARRPDRQQKSWSQ NT seq 1530 nt NT seq  +upstreamnt  +downstreamnt atgggggttcaggcagggctgtttgggatgctgggcttcctgggggtggccctggggggc tcccctgccctccgctggtacaggacctcctgccacttgaccaaggccgtccctggcaac ccactggggtacctgagcttcctggccaaggatgctcagggactggccctgatccatgcc cgctgggatgcgcataggaggctgcagtcatgtagctgggaggatgagccggagctcacc gcagcctacggtgctctctgtgctcatgagactgcctggggctccttcatccacaccccc ggacccgagctgcagagagcactggccactcttcagagtcagtgggaggcatgccgagcg cttgaggagagtccagcaggggccaggaagaagcgagcagcagggcagagtggagtccct ggtggagggcaccagcgagagaagagaggatggaccatgcctggcacactgtggtgtgga gttggagattctgctgggaactcctcggagctgggggtcttccagggacctgatctctgt tgccgggaacatgaccgctgcccacagaacatctcacccttgcagtacaactatggcatc cgaaactaccgattccacaccatctcccactgtgactgtgacaccaggtttcagcaatgc ctacagaatcagcacgactccatctcggacatcgtgggcgtggccttcttcaacgtgctg gagatcccctgctttgtgctggaggagcaggaggcgtgtgtggcgtggtactggtggggc gggtgtaggatgtacggcacagtgcccctcgctcgcctgcagcccaggaccttctacaat gcctcctggagctcccgggccacctccccaactcccagctcccggagcccagcccctccc aagcctcgacagaagcagcaccttcggaaggggccaccacatcagaaagggtccaagcgc cccagcaaagccaacaccacagccctccaggaccctatggtctctcccaggcttgatgtg gcccccacaggcctccagggcccacagggtggcctaaaacctcagggtgcccgctgggtc tgccgcagcttccgccgccacctggaccagtgtgagcaccagattgggccccgggaaatc gagttccagctgctcaacagcgcccaagagcccctcttccactgcaactgcacgcgccgt ctggcacgcttcctgaggctccacagcccacccgaggttaccaacatgctttgggagctg ctgggcacaacctgcttcaagctggcccctccactggactgtgtggaaggcaaaaactgt tccagagaccctagggccatcagggtgtcagcccggcacttgcggaggcttcagcagagg cgacaccagctccaggataaaggcacagatgagaggcagccatggccttcagagcccctg agaggccccatgtcattctacaaccagtgcctgcagctaacccaggcagccaggagaccc gacaggcagcagaagtcctggagccagtga

Homo sapiens (human): 5319 Help Entry 5319              CDS       T01001                                  Gene name PLA2G1B, PLA2, PLA2A, PPLA2 Definition (RefSeq) phospholipase A2 group IB   KO K01047   secretory phospholipase A2 [EC:3.1.1.4] Organism hsa  Homo sapiens (human) Pathway hsa00564   Glycerophospholipid metabolism hsa00565   Ether lipid metabolism hsa00590   Arachidonic acid metabolism hsa00591   Linoleic acid metabolism hsa00592   alpha-Linolenic acid metabolism hsa01100   Metabolic pathways hsa04014   Ras signaling pathway hsa04270   Vascular smooth muscle contraction hsa04972   Pancreatic secretion hsa04975   Fat digestion and absorption Drug target Varespladib (DG01394):  D06283 Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09103 Lipid metabolism    00564 Glycerophospholipid metabolism     5319 (PLA2G1B)    00565 Ether lipid metabolism     5319 (PLA2G1B)    00590 Arachidonic acid metabolism     5319 (PLA2G1B)    00591 Linoleic acid metabolism     5319 (PLA2G1B)    00592 alpha-Linolenic acid metabolism     5319 (PLA2G1B)  09130 Environmental Information Processing   09132 Signal transduction    04014 Ras signaling pathway     5319 (PLA2G1B)  09150 Organismal Systems   09153 Circulatory system    04270 Vascular smooth muscle contraction     5319 (PLA2G1B)   09154 Digestive system    04972 Pancreatic secretion     5319 (PLA2G1B)    04975 Fat digestion and absorption     5319 (PLA2G1B)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:hsa03036]     5319 (PLA2G1B) Enzymes [BR:hsa01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.1  Carboxylic-ester hydrolases     3.1.1.4  phospholipase A2      5319 (PLA2G1B) Chromosome and associated proteins [BR:hsa03036]  Eukaryotic type   Centrosome formation and ciliogenesis proteins    Centriole proteins     5319 (PLA2G1B) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Phospholip_A2_1 Parvo_coat_N Phospholip_A2_2 DUF1644 Motif Other DBs NCBI-GeneID:  5319 NCBI-ProteinID:  NP_000919 OMIM:  172410 HGNC:  9030 Ensembl:  ENSG00000170890 Vega:  OTTHUMG00000169343 Pharos:  P04054(Tchem) UniProt:  P04054 LinkDB All DBs Structure PDB:  3ELO Thumbnails Position 12q24.31 AA seq 148 aa AA seqDB search MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPV DELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNC DRNAAICFSKAPYNKAHKNLDTKKYCQS NT seq 447 nt NT seq  +upstreamnt  +downstreamnt atgaaactccttgtgctagctgtgctgctcacagtggccgccgccgacagcggcatcagc cctcgggccgtgtggcagttccgcaaaatgatcaagtgcgtgatcccggggagtgacccc ttcttggaatacaacaactacggctgctactgtggcttggggggctcaggcacccccgtg gatgaactggacaagtgctgccagacacatgacaactgctatgaccaggccaagaagctg gacagctgtaaatttctgctggacaacccgtacacccacacctattcatactcgtgctct ggctcggcaatcacctgtagcagcaaaaacaaagagtgtgaggccttcatttgcaactgc gaccgcaacgctgccatctgcttttcaaaagctccatataacaaggcacacaagaacctg gacaccaagaagtattgtcagagttga

Homo sapiens (human): 5320 Help Entry 5320              CDS       T01001                                  Gene name PLA2G2A, MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2 Definition (RefSeq) phospholipase A2 group IIA   KO K01047   secretory phospholipase A2 [EC:3.1.1.4] Organism hsa  Homo sapiens (human) Pathway hsa00564   Glycerophospholipid metabolism hsa00565   Ether lipid metabolism hsa00590   Arachidonic acid metabolism hsa00591   Linoleic acid metabolism hsa00592   alpha-Linolenic acid metabolism hsa01100   Metabolic pathways hsa04014   Ras signaling pathway hsa04270   Vascular smooth muscle contraction hsa04972   Pancreatic secretion hsa04975   Fat digestion and absorption Drug target Varespladib (DG01394):  D06283 Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09103 Lipid metabolism    00564 Glycerophospholipid metabolism     5320 (PLA2G2A)    00565 Ether lipid metabolism     5320 (PLA2G2A)    00590 Arachidonic acid metabolism     5320 (PLA2G2A)    00591 Linoleic acid metabolism     5320 (PLA2G2A)    00592 alpha-Linolenic acid metabolism     5320 (PLA2G2A)  09130 Environmental Information Processing   09132 Signal transduction    04014 Ras signaling pathway     5320 (PLA2G2A)  09150 Organismal Systems   09153 Circulatory system    04270 Vascular smooth muscle contraction     5320 (PLA2G2A)   09154 Digestive system    04972 Pancreatic secretion     5320 (PLA2G2A)    04975 Fat digestion and absorption     5320 (PLA2G2A)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:hsa03036]     5320 (PLA2G2A) Enzymes [BR:hsa01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.1  Carboxylic-ester hydrolases     3.1.1.4  phospholipase A2      5320 (PLA2G2A) Chromosome and associated proteins [BR:hsa03036]  Eukaryotic type   Centrosome formation and ciliogenesis proteins    Centriole proteins     5320 (PLA2G2A) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Phospholip_A2_1 Motif Other DBs NCBI-GeneID:  5320 NCBI-ProteinID:  NP_000291 OMIM:  172411 HGNC:  9031 Ensembl:  ENSG00000188257 Vega:  OTTHUMG00000002699 Pharos:  P14555(Tchem) UniProt:  P14555 A0A024RA96 LinkDB All DBs Structure PDB:  3U8I 1N28 5G3N 3U8D 1KVO 1KQU 1POD 1POE 1J1A 1DB4 1BBC 3U8H 3U8B 1AYP 1N29 1DCY 1DB5 Thumbnails Position 1p36.13 AA seq 144 aa AA seqDB search MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDAT DRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFAR NKTTYNKKYQYYSNKHCRGSTPRC NT seq 435 nt NT seq  +upstreamnt  +downstreamnt atgaagaccctcctactgttggcagtgatcatgatctttggcctactgcaggcccatggg aatttggtgaatttccacagaatgatcaagttgacgacaggaaaggaagccgcactcagt tatggcttctacggctgccactgtggcgtgggtggcagaggatcccccaaggatgcaacg gatcgctgctgtgtcactcatgactgttgctacaaacgtctggagaaacgtggatgtggc accaaatttctgagctacaagtttagcaactcggggagcagaatcacctgtgcaaaacag gactcctgcagaagtcaactgtgtgagtgtgataaggctgctgccacctgttttgctaga aacaagacgacctacaataaaaagtaccagtactattccaataaacactgcagagggagc acccctcgttgctga

Homo sapiens (human): 5322 Help Entry 5322              CDS       T01001                                  Gene name PLA2G5, FRFB, GV-PLA2, PLA2-10, hVPLA(2) Definition (RefSeq) phospholipase A2 group V   KO K01047   secretory phospholipase A2 [EC:3.1.1.4] Organism hsa  Homo sapiens (human) Pathway hsa00564   Glycerophospholipid metabolism hsa00565   Ether lipid metabolism hsa00590   Arachidonic acid metabolism hsa00591   Linoleic acid metabolism hsa00592   alpha-Linolenic acid metabolism hsa01100   Metabolic pathways hsa04014   Ras signaling pathway hsa04270   Vascular smooth muscle contraction hsa04972   Pancreatic secretion hsa04975   Fat digestion and absorption Disease H02440   Fleck retina, familial benign Drug target Varespladib (DG01394):  D06283 Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09103 Lipid metabolism    00564 Glycerophospholipid metabolism     5322 (PLA2G5)    00565 Ether lipid metabolism     5322 (PLA2G5)    00590 Arachidonic acid metabolism     5322 (PLA2G5)    00591 Linoleic acid metabolism     5322 (PLA2G5)    00592 alpha-Linolenic acid metabolism     5322 (PLA2G5)  09130 Environmental Information Processing   09132 Signal transduction    04014 Ras signaling pathway     5322 (PLA2G5)  09150 Organismal Systems   09153 Circulatory system    04270 Vascular smooth muscle contraction     5322 (PLA2G5)   09154 Digestive system    04972 Pancreatic secretion     5322 (PLA2G5)    04975 Fat digestion and absorption     5322 (PLA2G5)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:hsa03036]     5322 (PLA2G5) Enzymes [BR:hsa01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.1  Carboxylic-ester hydrolases     3.1.1.4  phospholipase A2      5322 (PLA2G5) Chromosome and associated proteins [BR:hsa03036]  Eukaryotic type   Centrosome formation and ciliogenesis proteins    Centriole proteins     5322 (PLA2G5) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Phospholip_A2_1 Phospholip_A2_2 Motif Other DBs NCBI-GeneID:  5322 NCBI-ProteinID:  NP_000920 OMIM:  601192 HGNC:  9038 Ensembl:  ENSG00000127472 Vega:  OTTHUMG00000002698 Pharos:  P39877(Tchem) UniProt:  P39877 LinkDB All DBs Position 1p36.13 AA seq 138 aa AA seqDB search MKGLLPLAWFLACSVPAVQGGLLDLKSMIEKVTGKNALTNYGFYGCYCGWGGRGTPKDGT DWCCWAHDHCYGRLEEKGCNIRTQSYKYRFAWGVVTCEPGPFCHVNLCACDRKLVYCLKR NLRSYNPQYQYFPNILCS NT seq 417 nt NT seq  +upstreamnt  +downstreamnt atgaaaggcctcctcccactggcttggttcctggcttgtagtgtgcctgctgtgcaagga ggcttgctggacctaaaatcaatgatcgagaaggtgacagggaagaacgccctgacaaac tacggcttctacggctgttactgcggctggggcggccgaggaacccccaaggatggcacc gattggtgctgttgggcgcatgaccactgctatgggcggctggaggagaagggctgcaac attcgcacacagtcctacaaatacagattcgcgtggggcgtggtcacctgcgagcccggg cccttctgccatgtgaacctctgtgcctgtgaccggaagctcgtctactgcctcaagaga aacctacggagctacaacccacagtaccaatactttcccaacatcctctgctcctag

Homo sapiens (human): 5406 Help Entry 5406              CDS       T01001                                  Gene name PNLIP, PL, PNLIPD, PTL Definition (RefSeq) pancreatic lipase   KO K14073   pancreatic triacylglycerol lipase [EC:3.1.1.3] Organism hsa  Homo sapiens (human) Pathway hsa00561   Glycerolipid metabolism hsa01100   Metabolic pathways hsa04972   Pancreatic secretion hsa04975   Fat digestion and absorption hsa04977   Vitamin digestion and absorption Module hsa_M00098   Acylglycerol degradation Disease H02330   Pancreatic lipase deficiency Drug target Cetilistat:  D09208<JP> Orlistat:  D04028<US> Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09103 Lipid metabolism    00561 Glycerolipid metabolism     5406 (PNLIP)  09150 Organismal Systems   09154 Digestive system    04972 Pancreatic secretion     5406 (PNLIP)    04975 Fat digestion and absorption     5406 (PNLIP)    04977 Vitamin digestion and absorption     5406 (PNLIP) Enzymes [BR:hsa01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.1  Carboxylic-ester hydrolases     3.1.1.3  triacylglycerol lipase      5406 (PNLIP) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Lipase PLAT Abhydrolase_6 Hydrolase_4 Abhydrolase_1 Retrotran_gag_3 Motif Other DBs NCBI-GeneID:  5406 NCBI-ProteinID:  NP_000927 OMIM:  246600 HGNC:  9155 Ensembl:  ENSG00000175535 Vega:  OTTHUMG00000019103 Pharos:  P16233(Tclin) UniProt:  P16233 LinkDB All DBs Structure PDB:  1LPB 1N8S 1LPA Thumbnails Position 10q25.3 AA seq 465 aa AA seqDB search MLPLWTLSLLLGAVAGKEVCYERLGCFSDDSPWSGITERPLHILPWSPKDVNTRFLLYTN ENPNNFQEVAADSSSISGSNFKTNRKTRFIIHGFIDKGEENWLANVCKNLFKVESVNCIC VDWKGGSRTGYTQASQNIRIVGAEVAYFVEFLQSAFGYSPSNVHVIGHSLGAHAAGEAGR RTNGTIGRITGLDPAEPCFQGTPELVRLDPSDAKFVDVIHTDGAPIVPNLGFGMSQVVGH LDFFPNGGVEMPGCKKNILSQIVDIDGIWEGTRDFAACNHLRSYKYYTDSIVNPDGFAGF PCASYNVFTANKCFPCPSGGCPQMGHYADRYPGKTNDVGQKFYLDTGDASNFARWRYKVS VTLSGKKVTGHILVSLFGNKGNSKQYEIFKGTLKPDSTHSNEFDSDVDVGDLQMVKFIWY NNVINPTLPRVGASKIIVETNVGKQFNFCSPETVREEVLLTLTPC NT seq 1398 nt NT seq  +upstreamnt  +downstreamnt atgctgccactttggactctttcactgctgctgggagcagtagcaggaaaagaagtttgc tacgaaagactcggctgcttcagtgatgactccccatggtcaggaattacggaaagaccc ctccatatattgccttggtctccaaaagatgtcaacacccgcttcctcctatatactaat gagaacccaaacaactttcaagaagttgccgcagattcatcaagcatcagtggctccaat ttcaaaacaaatagaaaaactcgctttattattcatggattcatagacaagggagaagaa aactggctggccaatgtgtgcaagaatctgttcaaggtggaaagtgtgaactgtatctgt gtggactggaaaggtggctcccgaactggatacacacaagcctcgcagaacatcaggatc gtgggagcagaagtggcatattttgttgaatttcttcagtcggcgttcggttactcacct tccaatgtgcatgtcattggccacagcctgggtgcccacgctgctggggaggctggaagg agaaccaatgggaccattggacgcatcacagggttggacccagcagaaccttgctttcag ggcacacctgaattagtccgattggaccccagcgatgccaaatttgtggatgtaattcac acggatggtgcccccatagtccccaatttggggtttggaatgagccaagtcgtgggccac ctagatttctttccaaatggaggagtggaaatgcctggatgtaaaaagaacattctctct cagattgtggacatagacggaatctgggaagggactcgagactttgcggcctgtaatcac ttaagaagctacaaatattacactgatagcatcgtcaaccctgatggctttgctggattc ccctgtgcctcttacaacgtcttcactgcaaacaagtgtttcccttgtccaagtggaggc tgcccacagatgggtcactatgctgatagatatcctgggaaaacaaatgatgtgggccag aaattttatctagacactggtgatgccagtaattttgcacgttggaggtataaggtatct gtcacactgtctggaaaaaaggttacaggacacatactagtttctttgttcggaaataaa ggaaactctaagcagtatgaaattttcaagggcactctcaaaccagatagtactcattcc aatgaatttgactcagatgtggatgttggggacttgcagatggttaaatttatttggtat aacaatgtgatcaacccaactttacctagagtgggagcatccaagattatagtggagaca aatgttggaaaacagttcaacttctgtagtccagaaaccgtcagggaggaagttctgctc accctcacaccgtgttag

Homo sapiens (human): 5407 Help Entry 5407              CDS       T01001                                  Gene name PNLIPRP1, PLRP1 Definition (RefSeq) pancreatic lipase related protein 1   KO K14074   pancreatic lipase-related protein 1 [EC:3.1.1.3] Organism hsa  Homo sapiens (human) Pathway hsa00561   Glycerolipid metabolism hsa01100   Metabolic pathways hsa04972   Pancreatic secretion hsa04975   Fat digestion and absorption Module hsa_M00098   Acylglycerol degradation Drug target Orlistat:  D04028<US> Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09103 Lipid metabolism    00561 Glycerolipid metabolism     5407 (PNLIPRP1)  09150 Organismal Systems   09154 Digestive system    04972 Pancreatic secretion     5407 (PNLIPRP1)    04975 Fat digestion and absorption     5407 (PNLIPRP1) Enzymes [BR:hsa01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.1  Carboxylic-ester hydrolases     3.1.1.3  triacylglycerol lipase      5407 (PNLIPRP1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Lipase PLAT Abhydrolase_6 Palm_thioest Abhydrolase_3 Abhydrolase_1 Lipase_3 LIDHydrolase DUF900 DUF676 Motif Other DBs NCBI-GeneID:  5407 NCBI-ProteinID:  NP_001290064 OMIM:  604422 HGNC:  9156 Ensembl:  ENSG00000187021 Vega:  OTTHUMG00000019109 Pharos:  P54315(Tbio) UniProt:  P54315 LinkDB All DBs Structure PDB:  2PPL Thumbnails Position 10q25.3 AA seq 467 aa AA seqDB search MLIFWTITLFLLGAAKGKEVCYEDLGCFSDTEPWGGTAIRPLKILPWSPEKIGTRFLLYT NENPNNFQILLLSDPSTIEASNFQMDRKTRFIIHGFIDKGDESWVTDMCKKLFEVEEVNC ICVDWKKGSQATYTQAANNVRVVGAQVAQMLDILLTEYSYPPSKVHLIGHSLGAHVAGEA GSKTPGLSRITGLDPVEASFESTPEEVRLDPSDADFVDVIHTDAAPLIPFLGFGTNQQMG HLDFFPNGGESMPGCKKNALSQIVDLDGIWAGTRDFVACNHLRSYKYYLESILNPDGFAA YPCTSYKSFESDKCFPCPDQGCPQMGHYADKFAGRTSEEQQKFFLNTGEASNFARWRYGV SITLSGRTATGQIKVALFGNKGNTHQYSIFRGILKPGSTHSYEFDAKLDVGTIEKVKFLW NNNVINPTLPKVGATKITVQKGEEKTVYNFCSEDTVREDTLLTLTPC NT seq 1404 nt NT seq  +upstreamnt  +downstreamnt atgctgatcttctggacaatcacacttttcctgctgggagcagccaaaggaaaagaagtt tgctatgaggacctcgggtgcttttctgacactgagccctggggcgggacagcaatcagg cccctgaaaattctcccctggagccctgagaagatcggcacccgcttcctgctgtacacc aatgaaaacccaaacaactttcaaattctcctcctctctgatccatcaacaattgaggca tcaaattttcaaatggacagaaagacccggttcatcatccatggcttcatagacaaagga gatgagagctgggtgacagacatgtgcaagaaactgttcgaggtggaggaggtgaactgc atctgcgtggactggaagaagggctcccaagccacctacacacaggctgccaacaacgtg cgagtggtgggcgcccaggtggcccagatgctcgacatcctcttgacagagtatagctac cccccttccaaagttcacctcattggccacagcctgggagcccacgtggctggagaggca ggaagcaagactccaggcctgagcaggattacagggttggatcctgtagaagcaagtttc gagagtactcctgaagaggtgcgacttgatccctctgatgctgactttgttgatgtgatt cacacggatgcagctcccctgatcccattcttgggttttggaacgaaccaacagatgggt catcttgacttcttccccaatggaggagagagcatgccgggatgcaagaagaatgccctg tctcagatcgtggatctagatggcatctgggcgggaacccgggactttgtggcttgcaat cacctaagaagctacaagtattacttggaaagcatcctcaatcccgatgggtttgctgca tatccctgcacttcctacaagtcctttgagtctgacaagtgcttcccgtgtccagatcaa ggatgcccacagatgggtcactatgctgataaatttgctggcaggacaagtgaagagcag cagaaattcttcttgaacacaggagaggctagcaatttcgctcgctggagatatggggtt tccatcacactgtctggaagaacagccactggtcagatcaaagttgctttgtttggaaat aagggaaacactcaccagtacagtatcttcagggggattctcaaaccaggctcaacccat tcctatgagtttgatgcaaagctggatgttggaacaattgagaaagtcaagtttctttgg aataacaatgtgataaatccaaccctccccaaagtgggtgccaccaagatcactgtgcaa aagggagaagagaagacagtgtacaacttctgtagcgaagacacagtgcgggaagacacg ctgctcaccctcacgccctgctaa

Homo sapiens (human): 5408 Help Entry 5408              CDS       T01001                                  Gene name PNLIPRP2, PLRP2 Definition (RefSeq) pancreatic lipase related protein 2 (gene/pseudogene)   KO K14075   pancreatic lipase-related protein 2 [EC:3.1.1.3] Organism hsa  Homo sapiens (human) Pathway hsa00561   Glycerolipid metabolism hsa01100   Metabolic pathways hsa04972   Pancreatic secretion hsa04975   Fat digestion and absorption Module hsa_M00098   Acylglycerol degradation Drug target Orlistat:  D04028<US> Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09103 Lipid metabolism    00561 Glycerolipid metabolism     5408 (PNLIPRP2)  09150 Organismal Systems   09154 Digestive system    04972 Pancreatic secretion     5408 (PNLIPRP2)    04975 Fat digestion and absorption     5408 (PNLIPRP2) Enzymes [BR:hsa01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.1  Carboxylic-ester hydrolases     3.1.1.3  triacylglycerol lipase      5408 (PNLIPRP2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Lipase PLAT Abhydrolase_6 Retrotran_gag_3 Abhydrolase_3 Abhydrolase_1 Ser_hydrolase Motif Other DBs NCBI-GeneID:  5408 NCBI-ProteinID:  NP_005387 OMIM:  604423 HGNC:  9157 Ensembl:  ENSG00000266200 Vega:  OTTHUMG00000181599 Pharos:  P54317(Tbio) UniProt:  P54317 LinkDB All DBs Structure PDB:  2OXE 2PVS Thumbnails Position 10q25.3 AA seq 469 aa AA seqDB search MLPPWTLGLLLLATVRGKEVCYGQLGCFSDEKPWAGTLQRPVKLLPWSPEDIDTRFLLYT NENPNNFQLITGTEPDTIEASNFQLDRKTRFIIHGFLDKAEDSWPSDMCKKMFEVEKVNC ICVDWRHGSRAMYTQAVQNIRVVGAETAFLIQALSTQLGYSLEDVHVIGHSLGAHTAAEA GRRLGGRVGRITGLDPAGPCFQDEPEEVRLDPSDAVFVDVIHTDSSPIVPSLGFGMSQKV GHLDFFPNGGKEMPGCKKNVLSTITDIDGIWEGIGGFVSCNHLRSFEYYSSSVLNPDGFL GYPCASYDEFQESKCFPCPAEGCPKMGHYADQFKGKTSAVEQTFFLNTGESGNFTSWRYK VSVTLSGKEKVNGYIRIALYGSNENSKQYEIFKGSLKPDASHTCAIDVDFNVGKIQKVKF LWNKRGINLSEPKLGASQITVQSGEDGTEYNFCSSDTVEENVLQSLYPC NT seq 1410 nt NT seq  +upstreamnt  +downstreamnt atgctgcccccttggaccctcggccttctcctgctggccacagtcagaggaaaagaggtc tgctacggacaacttggctgcttttctgatgaaaaaccatgggcaggaacccttcagcga cctgtaaaattacttccctggtcccccgaggacattgacacccgctttcttctgtacaca aatgaaaatccaaacaacttccaactaatcactggcacggaaccagacaccattgaggct tcaaacttccaactggaccgcaagacacgcttcatcatccatggcttcttagacaaggcg gaggacagctggccatcggacatgtgcaagaaaatgtttgaagtggagaaggtgaactgc atctgtgtggactggaggcacgggtcccgggcaatgtacacccaagccgtgcaaaacatt cgggttgttggggcggagacagctttcttaatacaagcactgtcgacgcagctagggtac agccttgaggacgtgcatgtcatcggccacagcctgggcgcgcacacggccgcggaggcg ggcaggaggctggggggccgcgtgggcaggatcacagggctggatccagcagggccgtgc ttccaggatgaacctgaggaggttcggttggatccatctgacgccgtgtttgtggatgtg attcacacagattcttctcccatagttccttccctaggtttcggaatgagccaaaaggtg ggccatctggatttctttccaaatggaggaaaggaaatgcccggatgtaagaaaaatgtc ctttcaaccattactgatattgatggaatatgggaaggaattggtggctttgtgtcttgc aatcacctaagaagcttcgagtattactcaagcagcgtcctcaaccctgatggcttcctg ggctatccctgtgcctcctacgatgagtttcaggagagtaagtgtttcccttgtccagct gaaggatgccccaaaatggggcactatgctgaccaatttaaggggaaaacaagtgctgtg gaacaaacctttttcctgaacacaggagagagtggtaactttactagttggagatataag gtatcagtcacactttctggaaaagagaaagtgaatgggtacatcaggattgctttgtat ggaagtaatgaaaactcaaaacaatatgagattttcaaaggatccctcaaaccagatgca agtcacacgtgtgctattgatgtggattttaatgttggaaaaatacagaaagttaaattc ctctggaacaaacgtgggataaatctatctgagcccaaactgggggcttcccaaatcaca gtgcaaagtggtgaagatgggactgagtataatttttgtagcagcgacactgtggaagaa aacgtcttgcaatctctttacccttgttaa

Homo sapiens (human): 64600 Help Entry 64600             CDS       T01001                                  Gene name PLA2G2F, GIIFsPLA2, sPLA2-IIF Definition (RefSeq) phospholipase A2 group IIF   KO K01047   secretory phospholipase A2 [EC:3.1.1.4] Organism hsa  Homo sapiens (human) Pathway hsa00564   Glycerophospholipid metabolism hsa00565   Ether lipid metabolism hsa00590   Arachidonic acid metabolism hsa00591   Linoleic acid metabolism hsa00592   alpha-Linolenic acid metabolism hsa01100   Metabolic pathways hsa04014   Ras signaling pathway hsa04270   Vascular smooth muscle contraction hsa04972   Pancreatic secretion hsa04975   Fat digestion and absorption Drug target Varespladib (DG01394):  D06283 Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09103 Lipid metabolism    00564 Glycerophospholipid metabolism     64600 (PLA2G2F)    00565 Ether lipid metabolism     64600 (PLA2G2F)    00590 Arachidonic acid metabolism     64600 (PLA2G2F)    00591 Linoleic acid metabolism     64600 (PLA2G2F)    00592 alpha-Linolenic acid metabolism     64600 (PLA2G2F)  09130 Environmental Information Processing   09132 Signal transduction    04014 Ras signaling pathway     64600 (PLA2G2F)  09150 Organismal Systems   09153 Circulatory system    04270 Vascular smooth muscle contraction     64600 (PLA2G2F)   09154 Digestive system    04972 Pancreatic secretion     64600 (PLA2G2F)    04975 Fat digestion and absorption     64600 (PLA2G2F)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:hsa03036]     64600 (PLA2G2F) Enzymes [BR:hsa01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.1  Carboxylic-ester hydrolases     3.1.1.4  phospholipase A2      64600 (PLA2G2F) Chromosome and associated proteins [BR:hsa03036]  Eukaryotic type   Centrosome formation and ciliogenesis proteins    Centriole proteins     64600 (PLA2G2F) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Phospholip_A2_1 Parvo_coat_N Motif Other DBs NCBI-GeneID:  64600 NCBI-ProteinID:  NP_073730 OMIM:  616793 HGNC:  30040 Ensembl:  ENSG00000158786 Vega:  OTTHUMG00000002704 Pharos:  Q9BZM2(Tchem) UniProt:  Q9BZM2 LinkDB All DBs Position 1p36.12 AA seq 211 aa AA seqDB search MADGAKANPKGFKKKVLDRCFSGWRGPRFGASCPSRTSRSSLGMKKFFTVAILAGSVLST AHGSLLNLKAMVEAVTGRSAILSFVGYGCYCGLGGRGQPKDEVDWCCHAHDCCYQELFDQ GCHPYVDHYDHTIENNTEIVCSDLNKTECDKQTCMCDKNMVLCLMNQTYREEYRGFLNVY CQGPTPNCSIYEPPPEEVTCSHQSPAPPAPP NT seq 636 nt NT seq  +upstreamnt  +downstreamnt atggcagatggggcaaaggccaaccccaaagggttcaaaaagaaggtgctggatagatgc ttctctgggtggaggggcccacgcttcggggcctcctgtccttcaagaacctccaggtct agcctgggtatgaagaagttcttcaccgtggccatccttgctggcagcgttctgtccaca gctcacggcagcctgctcaacctgaaggccatggtggaggccgtcacagggaggagcgcc atcctgtccttcgtgggctacggttgctactgtgggctggggggccgtggccagcccaag gatgaggtggactggtgctgccacgcccacgactgctgctaccaggaactctttgaccaa ggctgtcacccctatgtggaccactatgatcacaccatcgagaacaacactgagatagtc tgcagtgacctcaacaagacagagtgtgacaagcagacatgcatgtgtgacaagaacatg gttctgtgcctcatgaaccagacgtaccgagaggagtaccgtggcttcctcaatgtctac tgccagggccccacgcccaactgcagcatctatgaaccgccccctgaggaggtcacctgc agtcaccaatccccagcgccccccgcccctccctag

Homo sapiens (human): 81579 Help Entry 81579             CDS       T01001                                  Gene name PLA2G12A, GXII, PLA2G12, ROSSY Definition (RefSeq) phospholipase A2 group XIIA   KO K01047   secretory phospholipase A2 [EC:3.1.1.4] Organism hsa  Homo sapiens (human) Pathway hsa00564   Glycerophospholipid metabolism hsa00565   Ether lipid metabolism hsa00590   Arachidonic acid metabolism hsa00591   Linoleic acid metabolism hsa00592   alpha-Linolenic acid metabolism hsa01100   Metabolic pathways hsa04014   Ras signaling pathway hsa04270   Vascular smooth muscle contraction hsa04972   Pancreatic secretion hsa04975   Fat digestion and absorption Drug target Varespladib (DG01394):  D06283 Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09103 Lipid metabolism    00564 Glycerophospholipid metabolism     81579 (PLA2G12A)    00565 Ether lipid metabolism     81579 (PLA2G12A)    00590 Arachidonic acid metabolism     81579 (PLA2G12A)    00591 Linoleic acid metabolism     81579 (PLA2G12A)    00592 alpha-Linolenic acid metabolism     81579 (PLA2G12A)  09130 Environmental Information Processing   09132 Signal transduction    04014 Ras signaling pathway     81579 (PLA2G12A)  09150 Organismal Systems   09153 Circulatory system    04270 Vascular smooth muscle contraction     81579 (PLA2G12A)   09154 Digestive system    04972 Pancreatic secretion     81579 (PLA2G12A)    04975 Fat digestion and absorption     81579 (PLA2G12A)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:hsa03036]     81579 (PLA2G12A) Enzymes [BR:hsa01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.1  Carboxylic-ester hydrolases     3.1.1.4  phospholipase A2      81579 (PLA2G12A) Chromosome and associated proteins [BR:hsa03036]  Eukaryotic type   Centrosome formation and ciliogenesis proteins    Centriole proteins     81579 (PLA2G12A) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PLA2G12 Motif Other DBs NCBI-GeneID:  81579 NCBI-ProteinID:  NP_110448 OMIM:  611652 HGNC:  18554 Ensembl:  ENSG00000123739 Vega:  OTTHUMG00000131915 Pharos:  Q9BZM1(Tbio) UniProt:  Q9BZM1 Q542Y6 LinkDB All DBs Position 4q25 AA seq 189 aa AA seqDB search MALLSRPALTLLLLLMAAVVRCQEQAQTTDWRATLKTIRNGVHKIDTYLNAALDLLGGED GLCQYKCSDGSKPFPRYGYKPSPPNGCGSPLFGVHLNIGIPSLTKCCNQHDRCYETCGKS KNDCDEEFQYCLSKICRDVQKTLGLTQHVQACETTVELLFDSVIHLGCKPYLDSQRAACR CHYEEKTDL NT seq 570 nt NT seq  +upstreamnt  +downstreamnt atggccctgctctcgcgccccgcgctcaccctcctgctcctcctcatggccgctgttgtc aggtgccaggagcaggcccagaccaccgactggagagccaccctgaagaccatccggaac ggcgttcataagatagacacgtacctgaacgccgccttggacctcctgggaggcgaggac ggtctctgccagtataaatgcagtgacggatctaagcctttcccacgttatggttataaa ccctccccaccgaatggatgtggctctccactgtttggtgttcatcttaacattggtatc ccttccctgacaaagtgttgcaaccaacacgacaggtgctatgagacctgtggcaaaagc aagaatgactgtgatgaagaattccagtattgcctctccaagatctgccgagatgtacag aaaacactaggactaactcagcatgttcaggcatgtgaaacaacagtggagctcttgttt gacagtgttatacatttaggttgtaaaccatatctggacagccaacgagccgcatgcagg tgtcattatgaagaaaaaactgatctttaa

Homo sapiens (human): 8399 Help Entry 8399              CDS       T01001                                  Gene name PLA2G10, GXPLA2, GXSPLA2, SPLA2, sPLA2-X Definition (RefSeq) phospholipase A2 group X   KO K01047   secretory phospholipase A2 [EC:3.1.1.4] Organism hsa  Homo sapiens (human) Pathway hsa00564   Glycerophospholipid metabolism hsa00565   Ether lipid metabolism hsa00590   Arachidonic acid metabolism hsa00591   Linoleic acid metabolism hsa00592   alpha-Linolenic acid metabolism hsa01100   Metabolic pathways hsa04014   Ras signaling pathway hsa04270   Vascular smooth muscle contraction hsa04972   Pancreatic secretion hsa04975   Fat digestion and absorption Drug target Varespladib (DG01394):  D06283 Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09103 Lipid metabolism    00564 Glycerophospholipid metabolism     8399 (PLA2G10)    00565 Ether lipid metabolism     8399 (PLA2G10)    00590 Arachidonic acid metabolism     8399 (PLA2G10)    00591 Linoleic acid metabolism     8399 (PLA2G10)    00592 alpha-Linolenic acid metabolism     8399 (PLA2G10)  09130 Environmental Information Processing   09132 Signal transduction    04014 Ras signaling pathway     8399 (PLA2G10)  09150 Organismal Systems   09153 Circulatory system    04270 Vascular smooth muscle contraction     8399 (PLA2G10)   09154 Digestive system    04972 Pancreatic secretion     8399 (PLA2G10)    04975 Fat digestion and absorption     8399 (PLA2G10)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:hsa03036]     8399 (PLA2G10) Enzymes [BR:hsa01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.1  Carboxylic-ester hydrolases     3.1.1.4  phospholipase A2      8399 (PLA2G10) Chromosome and associated proteins [BR:hsa03036]  Eukaryotic type   Centrosome formation and ciliogenesis proteins    Centriole proteins     8399 (PLA2G10) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Phospholip_A2_1 Motif Other DBs NCBI-GeneID:  8399 NCBI-ProteinID:  NP_003552 OMIM:  603603 HGNC:  9029 Ensembl:  ENSG00000069764 Vega:  OTTHUMG00000048069 Pharos:  O15496(Tchem) UniProt:  O15496 LinkDB All DBs Structure PDB:  5OWC 6G5J 5G3M 5OW8 1LE6 1LE7 4UY1 Thumbnails Position 16p13.12 AA seq 165 aa AA seqDB search MGPLPVCLPIMLLLLLPSLLLLLLLPGPGSGEASRILRVHRRGILELAGTVGCVGPRTPI AYMKYGCFCGLGGHGQPRDAIDWCCHGHDCCYTRAEEAGCSPKTERYSWQCVNQSVLCGP AENKCQELLCKCDQEIANCLAQTEYNLKYLFYPQFLCEPDSPKCD NT seq 498 nt NT seq  +upstreamnt  +downstreamnt atggggccgctacctgtgtgcctgccaatcatgctgctcctgctactgccgtcgctgctg ctgctgctgcttctacctggccccgggtccggcgaggcctccaggatattacgtgtgcac cggcgtgggatcctggaactggcaggaactgtgggttgtgttggtccccgaacccccatc gcctatatgaaatatggttgcttttgtggcttgggaggccatggccagccccgcgatgcc attgactggtgctgccatggccacgactgttgttacactcgagctgaggaggccggctgc agccccaagacagagcgctactcctggcagtgcgtcaatcagagcgtcctgtgcggaccg gcagagaacaaatgccaagaactgttgtgcaagtgtgaccaggagattgctaactgctta gcccaaactgagtacaacttaaagtacctcttctacccccagttcctatgtgagccggac tcgcccaagtgtgactga

Homo sapiens (human): 84647 Help Entry 84647             CDS       T01001                                  Gene name PLA2G12B, FKSG71, GXIIB, GXIIIsPLA2, PLA2G13, sPLA2-GXIIB Definition (RefSeq) phospholipase A2 group XIIB   KO K01047   secretory phospholipase A2 [EC:3.1.1.4] Organism hsa  Homo sapiens (human) Pathway hsa00564   Glycerophospholipid metabolism hsa00565   Ether lipid metabolism hsa00590   Arachidonic acid metabolism hsa00591   Linoleic acid metabolism hsa00592   alpha-Linolenic acid metabolism hsa01100   Metabolic pathways hsa04014   Ras signaling pathway hsa04270   Vascular smooth muscle contraction hsa04972   Pancreatic secretion hsa04975   Fat digestion and absorption Drug target Varespladib (DG01394):  D06283 Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09103 Lipid metabolism    00564 Glycerophospholipid metabolism     84647 (PLA2G12B)    00565 Ether lipid metabolism     84647 (PLA2G12B)    00590 Arachidonic acid metabolism     84647 (PLA2G12B)    00591 Linoleic acid metabolism     84647 (PLA2G12B)    00592 alpha-Linolenic acid metabolism     84647 (PLA2G12B)  09130 Environmental Information Processing   09132 Signal transduction    04014 Ras signaling pathway     84647 (PLA2G12B)  09150 Organismal Systems   09153 Circulatory system    04270 Vascular smooth muscle contraction     84647 (PLA2G12B)   09154 Digestive system    04972 Pancreatic secretion     84647 (PLA2G12B)    04975 Fat digestion and absorption     84647 (PLA2G12B)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:hsa03036]     84647 (PLA2G12B) Enzymes [BR:hsa01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.1  Carboxylic-ester hydrolases     3.1.1.4  phospholipase A2      84647 (PLA2G12B) Chromosome and associated proteins [BR:hsa03036]  Eukaryotic type   Centrosome formation and ciliogenesis proteins    Centriole proteins     84647 (PLA2G12B) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PLA2G12 Motif Other DBs NCBI-GeneID:  84647 NCBI-ProteinID:  NP_115951 OMIM:  611653 HGNC:  18555 Ensembl:  ENSG00000138308 Vega:  OTTHUMG00000018446 Pharos:  Q9BX93(Tdark) UniProt:  Q9BX93 LinkDB All DBs Position 10q22.1 AA seq 195 aa AA seqDB search MKLASGFLVLWLSLGGGLAQSDTSPDTEESYSDWGLRHLRGSFESVNSYFDSFLELLGGK NGVCQYRCRYGKAPMPRPGYKPQEPNGCGSYFLGLKVPESMDLGIPAMTKCCNQLDVCYD TCGANKYRCDAKFRWCLHSICSDLKRSLGFVSKVEAACDSLVDTVFNTVWTLGCRPFMNS QRAACICAEEEKEEL NT seq 588 nt NT seq  +upstreamnt  +downstreamnt atgaagctggccagtggcttcttggttttgtggctcagccttgggggtggcctggctcag agcgacacgagccctgacacggaggagtcctattcagactggggccttcggcacctccgg ggaagctttgaatccgtcaatagctacttcgattcttttctggagctgctgggagggaag aatggagtctgtcagtacaggtgccgatatggaaaggcaccaatgcccagacctggctac aagccccaagagcccaatggctgcggctcctatttcctgggtctcaaggtaccagaaagt atggacttgggcattccagcaatgacaaagtgctgcaaccagctggatgtctgttatgac acttgcggtgccaacaaatatcgctgtgatgcaaaattccgatggtgtctccactcgatc tgctctgaccttaagcggagtctgggctttgtctccaaagtggaagcagcctgtgattcc ctggttgacactgtgttcaacaccgtgtggaccttgggctgccgcccctttatgaatagt cagcgggcagcttgcatctgtgcagaggaggagaaggaagagttatga

Homo sapiens (human): 8513 Help Entry 8513              CDS       T01001                                  Gene name LIPF, GL, HGL, HLAL Definition (RefSeq) lipase F, gastric type   KO K14452   gastric triacylglycerol lipase [EC:3.1.1.3] Organism hsa  Homo sapiens (human) Pathway hsa00561   Glycerolipid metabolism hsa01100   Metabolic pathways hsa04975   Fat digestion and absorption Module hsa_M00098   Acylglycerol degradation Drug target Orlistat:  D04028<US> Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09103 Lipid metabolism    00561 Glycerolipid metabolism     8513 (LIPF)  09150 Organismal Systems   09154 Digestive system    04975 Fat digestion and absorption     8513 (LIPF) Enzymes [BR:hsa01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.1  Carboxylic-ester hydrolases     3.1.1.3  triacylglycerol lipase      8513 (LIPF) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Abhydrolase_1 Abhydro_lipase Hydrolase_4 Abhydrolase_6 Esterase Motif Other DBs NCBI-GeneID:  8513 NCBI-ProteinID:  NP_004181 OMIM:  601980 HGNC:  6622 Ensembl:  ENSG00000182333 Vega:  OTTHUMG00000018695 Pharos:  P07098(Tclin) UniProt:  P07098 LinkDB All DBs Structure PDB:  1HLG Thumbnails Position 10q23.31 AA seq 398 aa AA seqDB search MWLLLTMASLISVLGTTHGLFGKLHPGSPEVTMNISQMITYWGYPNEEYEVVTEDGYILE VNRIPYGKKNSGNTGQRPVVFLQHGLLASATNWISNLPNNSLAFILADAGYDVWLGNSRG NTWARRNLYYSPDSVEFWAFSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIGFI AFSTNPSLAKRIKTFYALAPVATVKYTKSLINKLRFVPQSLFKFIFGDKIFYPHNFFDQF LATEVCSREMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTSVQNMFHWTQAVKS GKFQAYDWGSPVQNRMHYDQSQPPYYNVTAMNVPIAVWNGGKDLLADPQDVGLLLPKLPN LIYHKEIPFYNHLDFIWAMDAPQEVYNDIVSMISEDKK NT seq 1197 nt NT seq  +upstreamnt  +downstreamnt atgtggctgcttttaacaatggcaagtttgatatctgtactggggactacacatggtttg tttggaaaattacatcctggaagccctgaagtgactatgaacattagtcagatgattact tattggggatacccaaatgaagaatatgaagttgtgactgaagatggttatattcttgaa gtcaatagaattccttatgggaagaaaaattcagggaatacaggccagagacctgttgtg tttttgcagcatggtttgcttgcatcagccacaaactggatttccaacctgccgaacaac agccttgccttcattctggcagatgctggttatgatgtgtggctgggcaacagcagagga aacacctgggccagaagaaacttgtactattcaccagattcagttgaattctgggctttc agctttgatgaaatggctaaatatgaccttccagccacaatcgacttcattgtaaagaaa actggacagaagcagctacactatgttggccattcccagggcaccaccattggttttatt gccttttccaccaatcccagcctggctaaaagaatcaaaaccttctatgctctagctcct gttgccactgtgaagtatacaaaaagccttataaacaaacttagatttgttcctcaatcc ctcttcaagtttatatttggtgacaaaatattctacccacacaacttctttgatcaattt cttgctactgaagtgtgctcccgtgagatgctgaatctcctttgcagcaatgccttattt ataatttgtggatttgacagtaagaactttaacacgagtcgcttggatgtgtatctatca cataatccagcaggaacttctgttcaaaacatgttccattggacccaggctgttaagtct gggaaattccaagcttatgactggggaagcccagttcagaataggatgcactatgatcag tcccaacctccctactacaatgtgacagccatgaatgtaccaattgcagtgtggaacggt ggcaaggacctgttggctgacccccaagatgttggccttttgcttccaaaactccccaat cttatttaccacaaggagattcctttttacaatcacttggactttatctgggcaatggat gcccctcaagaagtttacaatgacattgtttctatgatatcagaagataaaaagtag

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