KEGG   Homo sapiens (human): 10564
Entry
10564             CDS       T01001                                 
Symbol
ARFGEF2, BIG2, PVNH2, dJ1164I10.1
Name
(RefSeq) ADP ribosylation factor guanine nucleotide exchange factor 2
  KO
K18442  brefeldin A-inhibited guanine nucleotide-exchange protein
Organism
hsa  Homo sapiens (human)
Pathway
hsa04144  Endocytosis
Disease
H00270  Periventricular nodular heterotopia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    10564 (ARFGEF2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    10564 (ARFGEF2)
Membrane trafficking [BR:hsa04131]
 Endosome - Golgi transport
  Arf GTPases and associated proteins
   Arf GTPase associated proteins
    10564 (ARFGEF2)
SSDB
Motif
Pfam: Sec7 BIG2_C Sec7-like_HUS DCB Sec7-like_HDS
Other DBs
NCBI-GeneID: 10564
NCBI-ProteinID: NP_006411
OMIM: 605371
HGNC: 15853
Ensembl: ENSG00000124198
Pharos: Q9Y6D5(Tbio)
UniProt: Q9Y6D5 Q59FR3 Q86TH5
Structure
LinkDB
Position
20:48921711..49036693
AA seq 1785 aa
MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPPKA
NFIEADKYFLPFELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVE
TICSCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQT
TAKATLTQMLNVIFTRMENQVLQEARELEKPIQSKPQSPVIQAAAVSPKFVRLKHSQAQS
KPTTPEKTDLTNGEHARSDSGKVSTENGDAPRERGSSLSGTDDGAQEVVKDILEDVVTSA
IKEAAEKHGLTEPERVLGELECQECAIPPGVDENSQTNGIADDRQSLSSADNLESDAQGH
QVAARFSHVLQKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGP
VFRTHEMFINAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNFKMHLKMQIEVFFKE
IFLNILETSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKI
AQGRSGHELGMTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQTSLGQERLTDQE
IGDGKGLDMARRCSVTSMESTVSSGTQTTVQDDPEQFEVIKQQKEIIEHGIELFNKKPKR
GIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEK
EFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLT
TDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKETKELTIATK
STKQNVASEKQRRLLYNLEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTP
LLAAYSIGLQNCDDTEVASLCLEGIRCAIRIACIFGMQLERDAYVQALARFSLLTASSSI
TEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKTRYLSGSGRE
REGSLKGHTLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVDRIFTGST
RLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGD
HFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIR
DMAIRCIAQMVNSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTCHIVTTIFQHHF
PAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAP
GDRVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKSYGHTFEKHWWQDLFRIVFR
IFDNMKLPEQLSEKSEWMTTTCNHALYAICDVFTQFYEALNEVLLSDVFAQLQWCVKQDN
EQLARSGTNCLENLVISNGEKFSPEVWDETCNCMLDIFKTTIPHVLLTWRPVGMEEDSSE
KHLDVDLDRQSLSSIDKNPSERGQSQLSNPTDDSWKGRPYANQKLFASLLIKCVVQLELI
QTIDNIVFYPATSKKEDAEHMVAAQQDTLDADIHIETEDQGMYKYMSSQHLFKLLDCLQE
SHSFSKAFNSNYEQRTVLWRAGFKGKSKPNLLKQETSSLACCLRILFRMYVDENRRDSWE
EIQQRLLTVCSEALAYFITVNSESHREAWTSLLLLLLTKTLKINDEKFKAHASMYYPYLC
EIMQFDLIPELRAVLRKFFLRIGVVYKIWIPEEPSQVPAALSPVW
NT seq 5358 nt   +upstreamnt  +downstreamnt
atgcaggagagccagaccaagagcatgttcgtgtcccgggccctggagaagatcctagcc
gacaaggaggtgaagcggccccagcactcccagctgcgcagggcctgccaggtggcgctc
gatgaaattaaagcagaaatagaaaagcagaggcttggcactgctgcaccaccaaaggca
aacttcattgaagctgacaagtattttcttccattcgagctagcttgccagtccaagtcc
ccaagggtagtcagcacatcccttgactgcttgcagaaactcatcgcatacgggcacatc
actggcaacgcccctgacagtggagcccctgggaagcggctgatcgacagaattgttgaa
accatttgcagttgttttcagggccctcagactgatgaaggggttcagttacaaataatt
aaggctcttctgactgcagtgacttccccacacattgaaattcatgagggtactatcctg
cagacagtgagaacatgttacaatatctatttggccagcaaaaatctcatcaatcaaacc
actgccaaggctacccttactcagatgctgaacgtcattttcacccgcatggaaaaccaa
gtgttgcaggaggccagagaactggaaaaaccaatccagtcaaaaccccagtcccctgtg
atccaagctgcagcagtatccccaaagttcgttcgtttgaagcacagtcaggcacaaagc
aaaccaacaactcccgaaaaaacagatttaaccaacggtgaacatgccaggagtgattct
ggaaaagtaagcacagaaaatggagacgcacccagagaaagaggctcatcactgtcaggg
actgatgacggagcccaggaggtggtgaaggacatcttggaagatgtagtcacatctgcc
attaaagaagcagcggaaaagcatggtctgacagaacctgagagagttctaggtgaactg
gagtgccaggaatgtgctattcccccaggagttgatgaaaactcacagaccaacgggata
gccgatgacaggcagtccttgtcgtcagcagataatctggaatcggatgcacaaggacat
caagtggctgccaggttctcccacgttctgcagaaggatgccttccttgtgttccgctcc
ctgtgcaagctgtccatgaaaccccttggtgaaggccctccagacccaaaatcccatgag
ctgcgttccaaggtggtttccctgcagctgctcctctctgtgttgcaaaatgctggcccc
gtattcaggactcacgagatgttcatcaatgcaatcaagcaatatctctgtgtggccttg
tccaaaaacggcgtctcttcagtgcctgatgtctttgagctctctcttgccatttttctt
actcttctttcaaactttaaaatgcacttgaaaatgcagatagaggtctttttcaaagag
attttcctgaacattttagaaacatcaacaagttcttttgagcacaggtggatggtcatt
cagactctgacgaggatctgtgcagatgcccagtgtgttgtggatatttatgtcaactac
gactgtgatttaaatgctgctaacatttttgagcgccttgtaaatgatttatccaaaatt
gctcagggaagaagtggacatgagctgggaatgacacctctgcaggagctcagcctgagg
aagaaaggcctggagtgcctcgtgtccattctcaagtgcatggtggagtggagcaaagac
ctgtatgtgaatcccaaccaccagaccagcctcggtcaggagaggctcacggatcaggaa
ataggggatgggaaaggccttgacatggcaagacggtgtagtgtgacgtccatggagtcc
acagtgtcctcggggacccagacaactgttcaggatgaccctgagcaatttgaggtcatc
aagcaacaaaaagaaatcattgaacacggcatcgagctgttcaacaagaaacccaagagg
gggatccagtttctccaggagcagggcatgctgggaacgtcagttgaagacatagcccaa
ttcctgcaccaggaggagcgcctggattccacccaagtaggcgattttctgggagatagc
gcaaggttcaacaaggaggtgatgtatgcctacgtggaccaacttgacttctgtgaaaaa
gaatttgtctcagccctgcggacattcctagaaggtttccgcctacctggagaagcccaa
aagattgaccgattaatggagaagtttgccgcaagatacatagaatgcaaccaagggcaa
actctgtttgctagtgctgacactgcttatgtcctagcgtattcaattattatgctgact
acagacttgcacagtcctcaggtaaaaaataaaatgacgaaagagcagtatattaaaatg
aatcggggtatcaatgatagtaaagatctgccagaagagtatctctcaagcatctatgaa
gagatagaaggcaagaaaattgcaatgaaagaaacaaaagagctaacgattgcaaccaaa
tctactaagcagaatgtagctagtgaaaagcagcggcggctgctgtacaacttagagatg
gagcaaatggctaaaacagccaaagctctgatggaggctgtgagccatgccaaagccccg
tttaccagtgccactcacctggaccatgtccggccaatgttcaaactggtgtggacgcca
ctattggcagcctacagcatcggactccagaactgtgatgacactgaagtggcctccttg
tgtttggaaggcatccgatgtgcaatccgaatcgcctgcatctttggaatgcagctggaa
cgagatgcctatgttcaggctcttgctcgcttctccctactcacagccagctccagcatc
acagaaatgaagcagaaaaacatcgacaccattaagacgcttatcacagtggctcacacc
gatggcaactaccttgggaattcctggcatgagatcttgaaatgcatcagccagctggag
ctcgctcagctgataggaaccggtgtgaagacgcgctacctgtctggatctgggcgtgaa
agagaagggagcctgaagggccacacattggcaggagaagagttcatgggccttggcctc
ggtaatttggtgagtggcggagtggataaaagacagatggccagcttccaagaatcggtt
ggtgagaccagctcgcagagtgtggttgtagctgtggacaggatttttactgggtctacc
agactggatggaaatgcaatagttgactttgtccgctggctgtgtgctgtgtccatggat
gaactggcttccccccaccatcctcgcatgttcagcttgcagaagattgtggagatatca
tactacaacatgaatcggatccgactacagtggtctcgaatatggcatgtgattggagat
cacttcaataaggttggctgcaaccctaatgaagatgtggctatctttgctgttgactca
ttaaggcaactctccatgaagtttcttgagaagggtgaattagccaacttccgtttccag
aaagattttctgaggccctttgagcatattatgaagaaaaacaggtctcccaccatccgg
gacatggcgatccgctgcattgcccagatggtgaactcccaggcggccaacatccgctca
ggttggaagaacatctttgccgtgttccaccaggcagcctctgatcatgatgggaacatt
gtggagctggccttccagaccacttgccacattgtcacaactattttccagcaccatttt
cctgcagccatcgattcctttcaggatgctgtgaagtgcttatcagagttcgcctgcaac
gccgctttccctgacacgagcatggaagcgattcggctcatccgcttctgtggcaaatac
gtctctgagaggcctcgggtgctacaagaatacacaagtgatgacatgaatgtagctcct
ggtgacagagtctgggtccgaggctggttccccatcttattcgaactctcctgcatcatt
aatagatgcaagttagatgtacgaacaaggggactcacagtcatgtttgagatcatgaag
agctatggccacacctttgaaaagcactggtggcaggacctgttcagaatcgtgtttcgg
atttttgacaatatgaaactccctgagcaactgtcagagaaatctgagtggatgacaaca
acctgcaatcacgcactttatgctatttgtgatgtttttacccagttttatgaagctttg
aatgaagttcttctttctgatgtatttgcacaattgcagtggtgtgtcaaacaagataat
gaacagttggcgcgatcaggtacaaattgcttagaaaacttagtaatatccaatggagag
aaattcagtcctgaagtctgggatgaaacctgcaactgtatgttggatattttcaaaaca
accatcccacatgttttgctgacatggagacctgtaggaatggaggaagattcatcagaa
aagcatttggatgtggatctggaccgccagtctttaagcagcatagataaaaatccctct
gagaggggacagagccagctctctaacccaacagatgacagctggaagggtagaccatac
gcaaatcagaaactgtttgccagcctcctcatcaagtgtgtggtccagttggaattgata
cagaccattgacaacattgtgttctaccctgcgacgagcaaaaaggaggatgcagagcac
atggttgccgcccagcaagacacgctggatgcagatatccacatagagacggaggatcag
ggcatgtataagtacatgtcttcccagcacctcttcaagctgttggactgtttgcaggaa
tcccattcattctcaaaggccttcaactccaattacgagcagcggactgtcctgtggcga
gcaggttttaagggcaagtctaaacccaatcttctaaaacaagaaaccagcagcctggcc
tgttgtttgaggatcctgtttcgaatgtatgttgatgagaaccgcagggattcctgggaa
gaaatacagcagagacttttaactgtttgcagtgaagctcttgcctatttcatcactgtg
aattctgagagccatcgggaggcctggacaagtctcttgttgttacttctaactaaaacc
ctcaaaataaatgatgaaaagttcaaagcacatgcttcaatgtactacccctacttgtgt
gaaattatgcagtttgacctgatccctgagctccgagcagttctgcggaagttcttccta
cggataggtgttgtgtataagatatggataccagaagagccatcacaggtaccagcagca
ctgtcaccagtgtggtag

KEGG   Homo sapiens (human): 10565
Entry
10565             CDS       T01001                                 
Symbol
ARFGEF1, ARFGEP1, BIG1, DEDISB, P200
Name
(RefSeq) ADP ribosylation factor guanine nucleotide exchange factor 1
  KO
K18442  brefeldin A-inhibited guanine nucleotide-exchange protein
Organism
hsa  Homo sapiens (human)
Pathway
hsa04144  Endocytosis
Disease
H02685  Developmental delay with neuropsychiatric disorders
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    10565 (ARFGEF1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    10565 (ARFGEF1)
Membrane trafficking [BR:hsa04131]
 Endosome - Golgi transport
  Arf GTPases and associated proteins
   Arf GTPase associated proteins
    10565 (ARFGEF1)
SSDB
Motif
Pfam: Sec7 BIG2_C Sec7-like_HUS DCB Sec7-like_HDS
Other DBs
NCBI-GeneID: 10565
NCBI-ProteinID: NP_006412
OMIM: 604141
HGNC: 15772
Ensembl: ENSG00000066777
Pharos: Q9Y6D6(Tbio)
UniProt: Q9Y6D6
Structure
LinkDB
Position
8:complement(67173511..67343781)
AA seq 1849 aa
MYEGKKTKNMFLTRALEKILADKEVKKAHHSQLRKACEVALEEIKAETEKQSPPHGEAKA
GSSTLPPVKSKTNFIEADKYFLPFELACQSKCPRIVSTSLDCLQKLIAYGHLTGNAPDST
TPGKKLIDRIIETICGCFQGPQTDEGVQLQIIKALLTAVTSQHIEIHEGTVLQAVRTCYN
IYLASKNLINQTTAKATLTQMLNVIFARMENQALQEAKQMEKERHRQHHHLLQSPVSHHE
PESPQLRYLPPQTVDHISQEHEGDLDLHTNDVDKSLQDDTEPENGSDISSAENEQTEADQ
ATAAETLSKNEVLYDGENHDCEEKPQDIVQNIVEEMVNIVVGDMGEGTTINASADGNIGT
IEDGSDSENIQANGIPGTPISVAYTPSLPDDRLSVSSNDTQESGNSSGPSPGAKFSHILQ
KDAFLVFRSLCKLSMKPLSDGPPDPKSHELRSKILSLQLLLSILQNAGPIFRTNEMFINA
IKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILETSTS
SFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRGSQELGM
SNVQELSLRKKGLECLVSILKCMVEWSKDQYVNPNSQTTLGQEKPSEQEMSEIKHPETIN
RYGSLNSLESTSSSGIGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYL
QEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSA
LRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHS
PQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKETKELTIPTKSSKQN
VASEKQRRLLYNLEMEQMAKTAKALMEAVSHVQAPFTSATHLEHVRPMFKLAWTPFLAAF
SVGLQDCDDTEVASLCLEGIRCAIRIACIFSIQLERDAYVQALARFTLLTVSSGITEMKQ
KNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKPRYISGTVRGREGSL
TGTKDQAPDEFVGLGLVGGNVDWKQIASIQESIGETSSQSVVVAVDRIFTGSTRLDGNAI
VDFVRWLCAVSMDELLSTTHPRMFSLQKIVEISYYNMGRIRLQWSRIWEVIGDHFNKVGC
NPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKRNRSPTIRDMVVRCI
AQMVNSQAANIRSGWKNIFSVFHLAASDQDESIVELAFQTTGHIVTLVFEKHFPATIDSF
QDAVKCLSEFACNAAFPDTSMEAIRLIRHCAKYVSDRPQAFKEYTSDDMNVAPEDRVWVR
GWFPILFELSCIINRCKLDVRTRGLTVMFEIMKTYGHTYEKHWWQDLFRIVFRIFDNMKL
PEQQTEKAEWMTTTCNHALYAICDVFTQYLEVLSDVLLDDIFAQLYWCVQQDNEQLARSG
TNCLENVVILNGEKFTLEIWDKTCNCTLDIFKTTIPHALLTWRPNSGETAPPPPSPVSEK
PLDTISQKSVDIHDSIQPRSVDNRPQAPLVSASAVNEEVSKIKSTAKFPEQKLFAALLIK
CVVQLELIQTIDNIVFFPATSKKEDAENLAAAQRDAVDFDVRVDTQDQGMYRFLTSQQLF
KLLDCLLESHRFAKAFNSNNEQRTALWKAGFKGKSKPNLLKQETSSLACGLRILFRMYMD
ESRVSAWEEVQQRLLNVCSEALSYFLTLTSESHREAWTNLLLLFLTKVLKISDNRFKAHA
SFYYPLLCEIMQFDLIPELRAVLRRFFLRIGVVFQISQPPEQELGINKQ
NT seq 5550 nt   +upstreamnt  +downstreamnt
atgtatgaggggaagaagacgaagaacatgttcctgacccgggctctggagaagatattg
gccgacaaggaagtgaagaaggcgcatcactcccagctgcgcaaagcttgcgaggtggcg
ttagaggaaataaaagcggaaactgaaaaacagagtcctcctcatggagaagcaaaagct
ggatcaagcacccttccaccagtgaaatcaaagacaaattttattgaagcagacaagtac
ttcttgccttttgagttggcatgccagtccaaatgtcctcgcatagttagtacatctcta
gattgcttacagaaacttattgcttatgggcacttgactggcaatgctccagatagtaca
acaccaggcaaaaaattaattgatagaattattgaaacaatatgtggctgctttcagggc
cctcagacagatgaaggagttcagctgcagataataaaggctttacttactgcagtaaca
tcacaacacatagaaattcatgaagggactgtactgcaagctgtgagaacatgttacaat
atctacttagcaagcaaaaatctcatcaatcagacaacagccaaagctactctcactcag
atgctaaatgttatctttgcacgcatggaaaaccaagcattacaggaagcaaaacaaatg
gaaaaagaaaggcatcggcagcatcatcatctgttacagtctccagtaagccatcacgag
cctgaatcacctcaacttagatatttgccacctcagactgttgatcatatatcccaagaa
cacgaaggggaccttgacctccatacaaatgatgtagataaaagtcttcaggatgacaca
gagcctgaaaatggatctgatatttccagtgcagaaaatgaacagactgaagctgatcag
gcaactgcagctgaaacattatctaaaaatgaagtgttatatgacggagaaaaccatgat
tgtgaggaaaagccacaagacattgtacagaacattgtagaagaaatggtgaacattgtt
gttggagatatgggagaagggactactataaatgcaagtgcagatggcaacattggaact
atagaggatggtagtgacagtgaaaatattcaagcaaatggaattccaggaacaccaatt
tctgttgcatatacaccatccttacctgatgatagattgtcagtctcttccaatgatact
caggaatctggaaattcttcaggaccttcacctggtgctaagttttcccacattttacaa
aaggatgcctttctagtattcaggtcattgtgtaaactgtcaatgaaaccactgtcagat
ggaccaccagatccaaagtctcatgaactacgatccaagattctttcattgcagttactt
ctatccattctgcagaatgcaggacctattttcaggacaaatgagatgtttattaatgct
attaagcagtatctttgtgttgcactctcaaaaaatggagtctcatctgttccagaggtt
tttgagctttctctttctatatttcttactttgttgtcaaatttcaagacacatctgaag
atgcaaattgaggtgttctttaaagaaattttcttatacattttggaaacttctaccagc
tcatttgatcacaaatggatggttattcagacactgacgaggatttgtgcagatgctcag
agtgtagtggatatttatgtaaactatgactgtgacttaaatgcagccaatatatttgaa
agactagtaaatgatctatcaaaaattgctcaaggaaggggcagtcaagaacttggtatg
agtaatgttcaggaattgagcctgaggaaaaaaggtttagaatgcttagtgtcgattttg
aagtgtatggttgaatggagtaaggatcagtatgtgaatcccaactcccagacaactctt
ggtcaggaaaaaccctcagagcaagagatgagtgaaatcaaacaccctgagacaataaac
agatacggaagtttaaattccctggagtcaacatcatcatcaggaataggcagctacagt
acacagatgtctggcactgataatccagaacaatttgaggtcctaaagcaacaaaaagaa
ataatagaacaagggatagatttatttaataagaaaccaaagagaggaatacagtacctc
caagaacaagggatgcttggcaccacacctgaagatattgcccaattcttacatcaagag
gaaagattagactctactcaagtgggtgagttcctgggagataatgataaatttaacaaa
gaagtcatgtatgcatatgtggaccaacatgacttttcaggaaaagacttcgtttcagcc
cttcgtatgtttctagaaggatttcgtcttccaggggaagctcagaaaatcgatcgatta
atggaaaaatttgctgcaagatacctagaatgcaaccaaggacaaactctctttgctagt
gcggatacagcttatgttttggcttattcaattatcatgttgaccacagaccttcacagt
ccacaggtgaaaaataaaatgacaaaggaacaatacattaagatgaatagaggtatcaat
gacagtaaagaccttcctgaagagtatctatcagccatctataatgaaatagctgggaaa
aagatatcaatgaaagaaacaaaagaactaacaatccctacaaaatcaagtaaacagaat
gtagccagtgaaaaacaaagaagacttctgtataacttagaaatggagcagatggccaag
acagctaaagcactcatggaggccgtgagccatgttcaggcaccctttacaagtgcaaca
catttggagcatgtgaggcccatgtttaagttggcttggacgccttttctggctgcattc
agtgtgggtctacaagattgtgatgatactgaagtagcctctctttgcctggaaggtata
agatgtgcaatcagaattgcatgcattttcagcattcagctggagagagatgcatatgtc
caggcactagcaagatttaccttactcacagtgagttccggtattactgaaatgaaacag
aagaacattgacacaataaaaacacttatcacagtggctcatacagatggaaattattta
ggaaattcatggcatgagattctgaagtgcatcagtcagttggagctggcacagcttata
ggaactggagtgaaacctcgatacatttctggaacagtgcgaggcagagaaggatctctt
actggaacaaaagatcaggctcctgatgaatttgtgggtttagggctagttggaggaaat
gtggactggaaacagatagcaagtattcaggaatccattggagaaaccagttctcagagt
gttgttgttgctgtagatagaatattcacaggatctacaaggctagatggaaatgccatt
gtggattttgtccgttggctctgtgctgtgtctatggatgaattactttccacgacacac
ccaagaatgtttagtctacaaaaaatagtagaaatatcatattacaacatgggaagaata
agattacagtggtctcgaatttgggaagttattggagatcattttaataaggttgggtgt
aatcctaatgaagatgtagctatttttgcagtagactccttgaggcagttgtcaatgaag
ttcttagagaaaggggagcttgctaacttcagattccagaaggatttcttaagacctttt
gaacatataatgaaacggaacaggtctccaacaattcgagatatggttgtacggtgtata
gcacagatggttaattctcaagctgctaacattcgatctggatggaagaacattttctct
gtatttcatctagctgcatctgatcaagatgaaagcatagtggaacttgcattccaaaca
accgggcacattgtcacccttgtatttgaaaaacactttccagcgaccattgattctttc
caggatgcagtgaagtgtttgtctgaatttgcgtgcaatgcagctttcccagacacaagt
atggaagcaattcgacttattcgccattgtgcaaaatatgtgtctgatagacctcaggct
ttcaaggaatacacaagcgatgatatgaacgtagcacctgaagacagggtgtgggtgaga
ggatggttcccaattctctttgagttatcctgtatcatcaatagatgcaaattagatgta
agaaccaggggtttaacagtaatgtttgaaataatgaaaacatatggccacacttatgag
aaacactggtggcaggatttatttagaattgttttcagaatctttgacaatatgaaattg
ccagaacaacagacagagaaagctgaatggatgacaacaacttgcaatcatgcactttat
gcaatctgtgatgtattcactcagtatttagaagtactcagtgatgtacttttggatgac
atttttgctcagctctactggtgtgtgcagcaagacaatgagcagttagcgcgatctggt
acaaactgtttagagaatgttgttattctgaatggtgaaaaatttaccctagaaatctgg
gataaaacttgcaactgcacactggatatcttcaaaaccacaatcccacatgcgctgttg
acctggcgacccaattctggagaaactgcccccccacctccatctcctgtaagtgaaaag
ccattggatacaatatcacagaagtctgtagatattcatgattctattcaaccaaggtct
gtggataacagaccacaagcaccactggtttctgcgtctgctgttaatgaagaagtcagc
aaaattaaatctacagcaaaatttccagaacaaaaattgtttgctgccctgttgattaaa
tgtgttgtgcagctggaactcatccagactatcgacaacattgtcttcttcccagccaca
agtaagaaagaagatgcagaaaacttagctgcagcacagagagatgcggtggactttgat
gttcgcgttgatactcaagaccaaggaatgtaccgctttttaacatcacaacaacttttt
aagctactggactgcttattagagtcacatagatttgcaaaagcgtttaattccaacaac
gaacagaggactgccctgtggaaagcaggattcaaaggcaaatccaagcccaaccttctg
aagcaggagaccagcagcctggcctgtgggctgcgcattctcttccggatgtacatggat
gagagccgcgttagtgcctgggaggaggtccagcagaggcttttgaatgtctgcagtgaa
gcactaagttacttcctcactctaacatcagaaagtcatcgagaagcctggactaactta
ctgcttttgtttctaactaaagttctaaagataagtgataataggtttaaagctcatgca
tcattctactaccctctcttatgtgaaattatgcaatttgacttgattcctgaacttcgt
gctgttcttagaagattttttctgcgaatcggagtagtttttcagatatcacaaccacct
gaacaggaacttggaataaacaagcaatga

KEGG   Homo sapiens (human): 23096
Entry
23096             CDS       T01001                                 
Symbol
IQSEC2, BRAG1, IQ-ArfGEF, MRX1, MRX18, MRX78, XLID1
Name
(RefSeq) IQ motif and Sec7 domain ArfGEF 2
  KO
K12495  IQ motif and SEC7 domain-containing protein
Organism
hsa  Homo sapiens (human)
Pathway
hsa04144  Endocytosis
Disease
H00480  X-linked intellectual developmental disorder
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    23096 (IQSEC2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    23096 (IQSEC2)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Arf GTPases and associated proteins
   Arf associated proteins
    23096 (IQSEC2)
SSDB
Motif
Pfam: Sec7 IQ_SEC7_PH SOS1_NGEF_PH PH_19 RHG20_PH SlyX
Other DBs
NCBI-GeneID: 23096
NCBI-ProteinID: NP_001104595
OMIM: 300522
HGNC: 29059
Ensembl: ENSG00000124313
Pharos: Q5JU85(Tdark)
UniProt: Q5JU85
Structure
LinkDB
Position
X:complement(53225813..53321350)
AA seq 1488 aa
MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRD
LREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNRE
GAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHP
GREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGE
NSRTVSVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQP
ASVALRKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQ
YRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAG
ARSHRLERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALN
CHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQ
GRPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPS
DSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPG
PLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDS
LREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGF
LSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKF
QSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSV
KAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVG
KKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYS
FRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESI
AEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGAL
SSSLRDLSDAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSN
SSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDG
QSKLQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHR
HFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPA
HKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPL
PPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV
NT seq 4467 nt   +upstreamnt  +downstreamnt
atggaggcggggtcggggcccccgggcggcccgggatccgagagcccaaatcgggccgtg
gagtacctgctggagctgaacaacatcatcgagagccagcagcagctgctggaaacccag
cggcggcgcatcgaggagctggagggccagctggaccagctcacccaggagaaccgcgac
ctgcgagaggagagccagctgcaccgcggggagctgcaccgggacccccacggcgcgcgg
gatagcccgggccgcgagagccagtaccagaacctgcgcgagacccagttccaccaccgc
gagctgcgggagagccagttccaccaggcggcccgggacgtgggctacccgaaccgggaa
ggcgcctaccagaatcgggaggctgtgtatcgggacaaggagcgggacgcctcctacccg
ctccaggacactaccggttacacagcccgcgagcgtgacgtggcccagtgccacctgcac
cacgagaacccagccctgggtcgcgagcgtggcgggcgggaggccgggccggcgcacccg
ggccgcgagaaggaagcgggctattcggcggcggtgggcgtggggccgcggccaccgcgg
gagcggggccagctgagccgtggcgcatccaggagctccagtcccggcgccggcggaggc
cacagcaccagtaccagcaccagcccggccacgaccctccagagaaaatctgatggtgag
aattccagaacagtcagtgtggagggtgatgccccaggcagtgacctgagcacagcggtt
gatagtcctgggagccaacccccctaccggctgagccagctgcccccctccagcagccac
atggggggcccccctgctggagtgggccttccctgggctcagcgggcacgcctccagcca
gccagtgtcgccctgaggaagcaggaggaggaggagataaagcgctccaaggccctatcg
gacagctatgaactctccacagacctgcaggacaagaaggtggaaatgctggagaggaag
tatgggggctccttcctgagccgcagggctgccaggaccatccagacagccttccgccag
taccgcatgaacaagaactttgagcggctacgcagctcagcctcagagagccgcatgtcc
cgccgcatcatcctttccaacatgcggatgcagttctcctttgaggagtatgagaaggca
cagaaccccgcgtacttcgagggcaagcctgcctcgctggacgagggtgccatggctggt
gcccggagccaccggcttgaacgggggctcccatatggaggctcctgtggtgggggcatc
gatggtggtggaagctccgtcaccacatctggagagttttctaatgacatcacagaactt
gaggactccttctccaaacaggtaaagtctctggctgaatccatcgacgaagccctgaac
tgccacccgtcagggcccatgtctgaggagccagggtcagcccagctggagaagcgggag
tcaaaggaacagcaagaggacagctcagccacatccttcagtgatcttcccctctacctg
gatgacacagttccccaacaatcccctgagcgactgcccagcacagaacccccaccccag
ggccggcccgagttctgggcgccagcccctctcccgccagttcctccaccagtgccatca
ggaacccgggaagacggtagccgtgaggaaggcactcgcaggggtcccgggtgcttggag
tgccgggatttccggctgcgggctgcccaccttcccctgcttaccattgagcctcctagt
gacagctccgtggacctgagtgaccgctcagatcgcggctctgtccaccgccagctggtg
tatgaggctgatggctgcagcccccatgggaccctgaagcacaaggggccaccaggcagg
gccccgatcccacaccgccactacccagcccctgaaggcccagccccagccccaccaggg
cccctgccaccagcccccaacagtggcactgggcccagtggtgtggctgggggtcggagg
ttggggaagtgcgaggcagcaggcgagaactctgatggtggagataacgagagccttgag
agctccagcaattccaatgagaccatcaactgcagctccggctcctcttctcgggacagt
ctaagggagcctccggctaccggcctgtgcaagcagacttaccagcgggagacaaggcat
agctgggactcgccagctttcaacaatgatgtggtccagaggcggcactaccgaatcggc
ctcaacctcttcaacaagaagccagagaagggtatccagtatctgatcgagcggggcttc
ctgtcagacacaccggtgggagtggctcacttcatcctggagcggaaaggcctcagccgg
cagatgataggggaattcctagggaaccggcagaagcagttcaacagagacgtgttggac
tgtgtggtggatgagatggacttctcctccatggatctggatgatgcgctccggaagttc
cagtcccatatccgggttcagggtgaggcccagaaagtggagcgactcatcgaagccttc
agccagcggtactgtgtctgtaacccagccctcgtgcgccagttccggaacccagacacc
atcttcatccttgcttttgccatcatcctcctcaataccgacatgtacagtcccagcgtc
aaagctgaacgaaagatgaaactagatgacttcatcaagaacctgagaggggttgacaat
ggtgaagacatcccccgagacctcctggtgggcatctaccagcgcatccaggggcgtgaa
ctgcggaccaacgatgaccatgtgtcccaggtgcaggctgtggagcgcatgattgttgga
aagaaaccagtcctgtctctccctcaccgtcgactggtttgctgctgccagctctacgag
gtgccagatccaaaccgcccccagaggctagggttgcatcagcgggaggtcttcctcttc
aatgatctccttgtggtcaccaaaattttccagaagaagaagatcttggtgacgtacagt
ttccgtcagtctttccccctcgtggaaatgcacatgcagctcttccagaattcatattac
cagtttgggatcaagttgctgtctgcagtacctggtggggagcgaaaagtcctcatcatc
ttcaatgcccccagcctccaggaccggctgcgctttacatccgacctgcgcgagtccatt
gcggaggtgcaggagatggagaaataccgtgtggagtcggagctggagaagcagaaaggt
atgatgcggcctaacgcctcacagcctggaggggccaaggactcagtgaatgggacgatg
gcccgcagtagcctggaggacacttacggggcaggcgatgggctcaaacggggcgcactc
agcagttccctgcgagacctctctgatgcagggaagcgggggcggcgtaacagcgtggga
tcgctggacagcaccatcgaagggtctgttattagcagtccacgccctcaccagaggatg
ccacctccgcccccacccccgccgccagaggagtacaagagccagaggcccgtctccaac
tcctcatccttcctgggctccctatttggaagcaagcggggcaaggggcccttccagatg
ccaccaccgccaacaggccaggcctctgcctcctcttcatctgcttcttccacgcaccac
caccaccaccaccaccatcatggccatagccacggtggcctgggggtgctgcctgatggg
cagtccaagctccaggccctgcatgcccagtattgccaaggaccgggccctgccccgcca
ccctacctcccaccccagcagccctctcttcccccacctccccagcagcccccacccttg
ccccagctgggctccattccaccgcctcccgcctcagccccacctgtggggccacatcgc
cacttccacgcccatggcccagtcccagggccccaacactataccttgggccggccaggc
agggcacccagacggggggctggaggacaccctcagtttgctccacatggccgccacccc
ctgcaccagcccacatccccactgcccctgtacagtcctgccccccagcaccctccagcc
cacaaacagggccctaagcacttcatcttcagccaccacccacagatgatgccagcagca
ggcgcggctgggggccctggatcccggccaccagggggctcctactcccacccccaccac
ccccagtcaccattgtcaccacactcacccatcccaccccacccctcctatccacccctc
cccccaccctcccctcacaccccgcactcaccccttccacccacctccccccatggcccg
ctgcacgcctctgggccccctggcacagccaacccccccagtgcaaaccccaaggccaag
ccaagccggatcagcaccgtggtctga

KEGG   Homo sapiens (human): 23362
Entry
23362             CDS       T01001                                 
Symbol
PSD3, EFA6D, EFA6R, HCA67
Name
(RefSeq) pleckstrin and Sec7 domain containing 3
  KO
K12494  PH and SEC7 domain-containing protein
Organism
hsa  Homo sapiens (human)
Pathway
hsa04144  Endocytosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    23362 (PSD3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    23362 (PSD3)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Arf GTPases and associated proteins
   Arf associated proteins
    23362 (PSD3)
SSDB
Motif
Pfam: Sec7 PH_9 PH PH_11 Sp38_C
Other DBs
NCBI-GeneID: 23362
NCBI-ProteinID: NP_056125
OMIM: 614440
HGNC: 19093
Ensembl: ENSG00000156011
Pharos: Q9NYI0(Tbio)
UniProt: Q9NYI0 B3KRC4
LinkDB
Position
8:complement(18527303..19084805)
AA seq 1047 aa
MEGRSAAAETFVWVNNASAHSQSVAKAKYEFLFGRSEGKAPDTSDHGGSTLLPPNVTNEF
PEYGTMEEGGEGLRASLEFDGEALPCHPQEQQGVQPLTGCHSGLDSVTEGPKDVREAPSQ
SHLKEQSLQPIDSLISALKATEARIISGTLQATKVLDQDAVSSFSVQQVEKELDTASRKT
QRVNKTLPAGQKNLPEIPLSAEVTTEESFYLSIQKDLTALLTGDTQAEISQIMNNGRKGA
VCVQEPSCPLASLGSSAVTCHSAGSVGFLKEQRSALGREHPGGCDRSSSMGRPGRVKHVE
FQGVEILWTGGDKRETQHPIDFETSLQRTASPDSKESSKVPRHLISSAGLCNSSSLTENV
WDESWKAPSERPGTSSGTFSPVRLDESGEDEVFLQENKQHLEKTPKPERDRERISEQEEH
VKGEDEDILGPGYTEDSTDVYSSQFETILDNTSLYYSAESLETLYSEPDSYFSFEMPLTP
MIQQRIKEGGQFLERTSGGGHQDILSVSADGGIVMGYSSGVTNGLNDASDSIYTKGTPEI
AFWGSNAGVKTTRLEAHSEMGSTEILEKETPENLSNGTSSNVEAAKRLAKRLYQLDRFKR
SDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIHFS
NRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIANLQGVNEGVDFSK
DLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRIGSTTNPFLDIPHD
PNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEED
LKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFS
APPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVKA
KDVDEYKLKDHYLEFEKTRYEMYVSILKEGGKELLSNDESEAAGLKKSHSSPSLNPDTSP
ITAKVKRNVSERKDHRPETPSIKQKVT
NT seq 3144 nt   +upstreamnt  +downstreamnt
atggaaggaaggagcgcagcggcagagacatttgtttgggtgaacaatgcatctgcacat
tcccagagtgttgccaaggccaaatatgaatttttatttggcagatctgaagggaaagct
ccagatactagtgatcatggaggaagcactttactcccaccaaatgtcacaaatgaattt
ccagaatatgggaccatggaggaaggtggagaaggcctaagggcttctctggaatttgat
ggtgaggctctgccatgccacccacaagagcagcagggtgtccagcctcttactggctgc
cactctgggctcgacagtgttacagaaggaccaaaagatgtcagagaggccccctctcaa
agtcatctcaaggaacaaagtttacagcccattgactctttgatttcagctctgaaagcc
acagaagccagaatcatttccggaacattacaggctacaaaggtactggaccaagatgct
gtttctagtttttcagttcagcaggtggaaaaagagctggacactgccagtcgtaaaaca
cagagagtcaacaaaacgctccctgctggccaaaaaaatttaccagaaatacctctttca
gctgaagtaacaacggaggaaagtttttatttgagcatccagaaagatctcaccgcgctg
ttaactggagacactcaggcagagatttcccagataatgaataatgggaggaaaggggct
gtctgtgtgcaggagccatcttgtcctttggcctccctcgggagctcagcagtgacctgc
cactctgcaggcagtgttggtttcttgaaagagcagaggtctgctcttgggagagagcac
ccagggggatgtgatcgaagcagctccatgggacgcccaggccgggtcaaacatgtggaa
tttcaaggagtggaaatactgtggacaggaggagacaagagagagacccagcatcctata
gattttgagacatcactgcaaagaacagcctctcctgacagcaaagagtcttccaaagtg
ccacgccatctcatctcatcagctggtttgtgtaattcaagtagtttaactgagaatgtt
tgggatgaatcctggaaagctccttcagagaggcctggcactagctcggggacattttcc
cctgtgcgtcttgatgagagtggagaggatgaagtcttcctacaggaaaacaaacagcat
cttgagaagacacctaaaccagagagagacagggaaaggatcagcgaacaagaggagcac
gttaagggggaagatgaagacatccttgggcctggatatacggaggactccaccgacgtg
tacagctcccagtttgaaaccattttggacaacacttctttatactacagtgcagagtcc
ctggagacattatactcagagcctgatagctattttagctttgaaatgcccctcactcca
atgatacaacagcgcattaaagaaggtggtcagttcttggagaggacatcagggggagga
catcaggatatcctgagtgtgtctgcagatggtggcatcgtgatgggctattctagtggc
gtcaccaatgggctgaatgatgccagcgactccatctacacgaaaggcaccccggagatt
gctttctggggaagcaatgctggggtgaaaacaacacggctagaagctcattctgaaatg
gggagcactgaaattttggaaaaggagaccccagaaaatctcagtaatggtaccagcagc
aatgtggaagcagccaaaaggttggccaaacgcctttatcagctggacagattcaaaaga
tcagatgttgcaaaacaccttggcaagaacaacgaatttagcaaactagttgcagaagaa
tatctgaagttttttgattttacaggaatgacgctggatcagtcactcaggtatttcttt
aaagcattctctcttgtgggagaaactcaagaacgagagagagttttaatacacttctcc
aatagatatttttattgtaacccagataccattgcttcacaagatggagtccattgcctt
acctgtgcaataatgcttcttaataccgatctacatggccacaatattggaaagaagatg
acctgtcaggagttcattgcaaatctgcaaggggtaaatgagggtgttgatttctccaag
gatctgctgaaagctctgtacaactcaatcaagaatgagaagcttgaatgggcagtagat
gatgaagagaaaaaaaagtctccctcagaaagtactgaggagaaagctaacggaacacat
ccaaagaccatcagtcgtattggaagtactactaacccatttttggacattcctcatgat
ccaaatgctgctgtgtacaaaagtggattcttggctcggaaaattcatgcagatatggat
ggaaagaagactccaagaggaaaacgaggatggaaaaccttttatgctgtactgaaggga
acagttctttacttgcaaaaggatgaatacaagccagaaaaggccttgtctgaagaggac
ttgaaaaacgctgtgagtgtgcaccacgcattggcatccaaggccacggactatgagaag
aaaccaaacgtgtttaaacttaaaactgccgactggagggtcttgctttttcaaactcag
agcccagaggaaatgcaagggtggataaacaaaatcaattgtgtggcagctgtattttct
gcaccaccatttccagcagcaatcggctctcagaagaagtttagccgcccacttctgcct
gccactacaacaaaactgtctcaggaggagcaactgaagtcacatgaaagtaagctgaag
cagatcaccaccgagctggccgagcaccgctcatatccccccgacaagaaggtcaaagcc
aaggacgtcgatgagtacaaactgaaagaccactatctggagtttgagaaaacccgctat
gaaatgtatgtcagcattctcaaggaaggaggcaaagagctactgagtaacgatgaaagc
gaggctgcaggactgaagaagtcgcactcgagtccttcgctgaacccggatacttctcca
atcactgccaaagtcaagcgtaacgtgtcagagaggaaggatcaccgacctgaaacacca
agcattaagcaaaaagttacttag

KEGG   Homo sapiens (human): 23550
Entry
23550             CDS       T01001                                 
Symbol
PSD4, EFA6B, TIC
Name
(RefSeq) pleckstrin and Sec7 domain containing 4
  KO
K12494  PH and SEC7 domain-containing protein
Organism
hsa  Homo sapiens (human)
Pathway
hsa04144  Endocytosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    23550 (PSD4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    23550 (PSD4)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Arf GTPases and associated proteins
   Arf associated proteins
    23550 (PSD4)
SSDB
Motif
Pfam: Sec7 PH_9 PH
Other DBs
NCBI-GeneID: 23550
NCBI-ProteinID: NP_036587
OMIM: 614442
HGNC: 19096
Ensembl: ENSG00000125637
Pharos: Q8NDX1(Tdark)
UniProt: Q8NDX1
LinkDB
Position
2:113173971..113209391
AA seq 1056 aa
MMGDYRLPDHPQPMEILNLYLGDSLEPHPGECPRETCSHEDPPEPFEEQTWATDPPEPTR
QNVPPWGSGVELTHLGSWVHQDGLEPCQEQTRATDPPESTRQDAPPWGSGVELTHLGSPS
AQREHRQNTASPGSPVNSHLPGSPKQNRSTSTQVVFWAGILQAQMCVLDLEEELEKTEGL
KAGLKCCLPTPPVDLPGDTGLHSSPPENEDSGEDSSEPEGEGQAWLREGTPDSSPQWGAE
EESMFFSNPLFLASPCSENSASGECFSWGASDSHAGVRTGPESPATLEPPLPEDTVLWEL
ESEPDLGDGAAISGHCTPPFPVPIYKPHSICWASVAAAEGAPAAPPGHGESEGDRLGPAP
SAAPCVDEALTWESGCVGSDLGPAAHPVQPWASLSPEGWQRGGPFWPQVTLNSQDRDERE
GGHPQESLPCTLAPCPWRSPASSPEPSSPESESRGPGPRPSPASSQEGSPQLQHHSSGIL
PKWTLDASQSSLLETDGEQPSSLKKKEAGEAPKPGEEVKSEGTARPAETGDVQPDIHLTS
AEHENLRTPMNSSWLPGSPMPQAQSPEEGQRPPAGDKLANGVRNNKVAWNLASRLYRLEG
FRKSEVAAYLQKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLSGETQERERILY
QFSRRFHHCNPGIFPSVDSVHTLTCAIMLLNTDLHGQNIGKSMSCQEFITNLNGLRDGGN
FPKELLKALYWSIRSEKLEWAVDEEDTARPEKAQPSLPAGKMSKPFLQLAQDPTVPTYKQ
GILARKMHQDADGKKTPWGKRGWKMFHTLLRGMVLYFLKQGEDHCLEGESLVGQMVDEPV
GVHHSLATPATHYTKKPHVFQLRTADWRLYLFQAPTAKEMSSWIARINLAAATHSAPPFP
AAVGSQRRFVRPILPVGPAQSSLEEQHRSHENCLDAAADDLLDLQRNLPERRGRGRELEE
HRLRKEYLEYEKTRYETYVQLLVARLHCPSDALDLWEEQLGREAGGTREPKLSLKKSHSS
PSLHQDEAPTTAKVKRNISERRTYRKIIPKRNRNQL
NT seq 3171 nt   +upstreamnt  +downstreamnt
atgatgggtgactacagactccctgaccacccccagcccatggaaattctcaacctgtac
ttgggagacagcctggagccccacccaggagagtgcccaagggaaacgtgcagccatgag
gatccaccggagcctttcgaggagcaaacctgggccactgaccctcctgaacctaccaga
caaaatgttcctccctggggctccggtgtggagctcacacacctggggagctgggtccat
caggacgggctggagccttgccaggagcaaacccgggccactgaccctcctgaatctacc
agacaagatgctcctccctggggctccggtgtggagctcacacacctggggagcccctct
gcccagagggagcacaggcagaacacagcatcaccagggtcaccagtgaacagccatcta
ccggggagcccaaagcagaaccggagcacgtccacacaggtagtgttctgggcaggcatc
ctgcaggcccagatgtgtgtcctagacctggaggaggagctggagaagacggaagggctc
aaggctgggctgaaatgctgtctccccacgccccctgtggacctccccggggacacgggc
ctgcactccagcccacctgagaatgaagactcaggggaagacagcagtgagcctgaggga
gagggccaggcatggctgagagagggaaccccagactcttccccacagtggggagctgag
gaggagagcatgttcttcagcaaccccctcttcctggcgagtccttgctcagagaacagt
gcttctggagagtgcttttcctggggggcttcagactcccatgcaggtgtgaggactgga
cctgagagcccagcgactctggagcctcccctcccagaagacacagtgctgtgggagctg
gaaagtgagccagatttgggggacggcgctgctatcagtgggcattgtacccctccattc
cctgtgcccatctataaaccacactccatctgctgggcctcagtggctgccgctgagggg
gctcctgcagcacctcctggtcacggggagagtgagggagataggcttggtcctgctcca
tctgcagcaccgtgtgtggacgaagcattgacctgggaatcaggatgtgtcggatctgat
cttggccctgctgcacatcctgtgcaaccttgggcctctctcagccctgagggctggcag
agaggaggtcctttttggccccaggtgactcttaactcccaggacagagatgagagggag
ggtggacacccccaggaatctcttccctgcaccttggccccctgcccctggaggagccca
gcttcttctccagagcctagcagcccagaatctgagagcagaggccctggtcccaggccc
agccctgcatcgtcccaggagggcagcccgcagcttcaacaccacagctcaggcattttg
cccaagtggacactagatgcttcacagtcttcactcttggagacggatggggaacagcca
agttccttgaagaaaaaggaggcaggggaggccccaaaaccaggcgaggaagtaaagagt
gaaggaacagccaggcctgcagagactggagacgtccagcctgacattcacctgacttct
gcagaacatgagaatctgaggacaccgatgaactcttcttggcttcctgggagccctatg
ccccaagcacagtccccagaggaaggccagagaccaccagctggagacaagctagctaat
ggcgtcaggaacaacaaggtagcctggaacttggcctcacgcctctatcgcctggagggc
ttccggaagtctgaagtggctgcctacctgcagaagaacaatgactttagcagggctgtg
gctgaggagtacctgtccttcttccagtttggaggccagagtctggaccgagccctccgg
agcttcctccaggccttggtgctcagtggggagactcaggaacgggagcgaatcctctac
cagttctccagacgcttccaccattgcaatccggggatcttcccctcagtagattctgta
cacaccttgacatgtgcaatcatgctgcttaacacggacctgcatggacagaacattggg
aagagcatgagctgccaggaattcataaccaacctgaatgggctgagggatggcgggaac
ttccccaaggagctgctgaaggccctctactggtctatccgcagcgagaagctcgagtgg
gccgtggatgaagaagacacagccagacctgagaaggcccagccgtccctgccagctggc
aagatgagcaagcccttccttcagctggctcaggatcccacagtgcccacctacaagcag
ggcatcctggctcggaaaatgcatcaagatgcagacggcaagaagacgccatggggcaag
cgtggctggaagatgttccacaccttactgcgagggatggttctctacttcctgaagcag
ggagaagaccactgtctggagggggagagcttggtggggcagatggtggatgagcccgtg
ggggtgcaccactcgctggccacccccgccacgcattacaccaagaagccgcacgtcttc
cagctgcgcacggctgactggcgcctctacctcttccaggcacccactgccaaggagatg
agctcctggatcgcgcgcatcaacttggctgcggccacgcactccgcgccgcccttcccc
gccgctgtgggctcccagcgcagattcgtgcggcccatcctgcccgtgggccccgcccag
agctccctggaggagcagcatcgatcccacgagaactgcctggacgctgccgcggacgac
ctgctggatctacagaggaacctgccggagcggcggggccgtggccgcgagctggaggag
caccgcctgcggaaggagtacctggagtacgagaaaacccgctacgagacctacgtgcag
ctgctggtggcccgcctgcactgcccctctgatgctctggacctgtgggaggagcagctg
gggagggaagctggaggcactcgggagcccaagctcagcctgaagaagtcccactcgagc
ccgtccctgcaccaggatgaggctcccaccacggccaaggtgaagcgcaacatctcagag
cgcagaacctaccggaagatcatccctaagcggaaccgcaatcagctgtga

KEGG   Homo sapiens (human): 27128
Entry
27128             CDS       T01001                                 
Symbol
CYTH4, CYT4, DJ63G5.1, PSCD4, cytohesin-4
Name
(RefSeq) cytohesin 4
  KO
K18441  cytohesin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04072  Phospholipase D signaling pathway
hsa04144  Endocytosis
hsa05130  Pathogenic Escherichia coli infection
hsa05131  Shigellosis
hsa05132  Salmonella infection
Network
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06182  Shigella
  Element
N01066  ARNO-ARF-ACTB_G signaling pathway
N01067  Shigella IpgD to ARNO-ARF-ACTB_G signaling pathway
N01129  Salmonella SopB to ARNO-ARF-ACTB/G signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    27128 (CYTH4)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    27128 (CYTH4)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    27128 (CYTH4)
   05131 Shigellosis
    27128 (CYTH4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    27128 (CYTH4)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Arf GTPases and associated proteins
   Arf associated proteins
    27128 (CYTH4)
 Endosome - Golgi transport
   Arf GTPase associated proteins
    27128 (CYTH4)
SSDB
Motif
Pfam: Sec7 PH PH_11 Syntaxin-6_N PH_20 PH_3 PH_8
Other DBs
NCBI-GeneID: 27128
NCBI-ProteinID: NP_037517
OMIM: 606514
HGNC: 9505
Ensembl: ENSG00000100055
Pharos: Q9UIA0(Tbio)
UniProt: Q9UIA0
LinkDB
Position
22:37282508..37315341
AA seq 394 aa
MDLCHPEPAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQ
KEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDP
INLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQ
STDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKS
EPFSIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPR
GIIPLENLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSA
EERDQWIESIRASITRVPFYDLVSTRKKKIASKQ
NT seq 1185 nt   +upstreamnt  +downstreamnt
atggacctgtgccacccagagcccgcggagctgagcagcggggagacggaagagttacag
aggatcaagtggcaccgaaagcagctcctggaggacatccagaagctgaaggatgagatt
gcagatgtgtttgcccaaatcgactgcttcgagagtgcggaggagagccggatggcccag
aaggagaaggagctgtgtattgggcgcaagaagttcaacatggaccccgccaagggtatc
cagtatttcattgagcacaagctgctgacccctgacgtccaggacattgcacggttcctg
tataaaggcgagggcctcaacaagacagccattggtacctacctgggggagagggatccc
atcaacctgcaggtcctccaggccttcgtggactgccacgagttcgccaacctcaacctc
gtccaggccctcaggcagttcctgtggagcttccggctgccgggcgaggcccagaagata
gaccggatgatggaggcctttgccactcgatactgcctctgcaacccaggcgtcttccag
tccacagacacctgctacgtgttgtccttctccatcatcatgctcaacaccagcctccac
aatcccaacgtccgggacaggccgccttttgagcgctttgtgtccatgaaccgcggcatc
aacaatggtagcgacctgcccgaggaccagctgcggaacctcttcgacagcatcaagagt
gagccattctccatccctgaggacgacggcaatgacctcactcacaccttcttcaatcca
gaccgggagggttggctgctcaagctagggggccgcgtgaagacgtggaaacggcgctgg
ttcatcctgaccgacaactgcctctactacttcgagttcaccactgacaaggagccacgg
ggaattatacctcttgagaacctctcggtgcagaaggtggatgaccccaagaagccattc
tgcctggagctctacaaccctagctgccgaggccagaaaatcaaggcctgcaagaccgat
ggcgacggcagggtggtggagggcaagcacgaatcgtaccgcatctcagccaccagtgcc
gaggaacgtgaccagtggatcgagtccatccgagccagcatcacccgtgtccccttctac
gacctggtctctactcggaagaagaagattgccagcaagcagtga

KEGG   Homo sapiens (human): 440073
Entry
440073            CDS       T01001                                 
Symbol
IQSEC3
Name
(RefSeq) IQ motif and Sec7 domain ArfGEF 3
  KO
K12495  IQ motif and SEC7 domain-containing protein
Organism
hsa  Homo sapiens (human)
Pathway
hsa04144  Endocytosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    440073 (IQSEC3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    440073 (IQSEC3)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Arf GTPases and associated proteins
   Arf associated proteins
    440073 (IQSEC3)
SSDB
Motif
Pfam: Sec7 IQ_SEC7_PH SOS1_NGEF_PH PH_19 SlyX RHG20_PH bZIP_1 CREPT DivIC
Other DBs
NCBI-GeneID: 440073
NCBI-ProteinID: NP_001164209
OMIM: 612118
HGNC: 29193
Ensembl: ENSG00000120645
Pharos: Q9UPP2(Tdark)
UniProt: Q9UPP2
LinkDB
Position
12:66767..178455
AA seq 1182 aa
MESLLENPVRAVLYLKELTAIVQNQQSLIHTQRERIDELERRLDELSAENRSLWEHQQLL
QAQPPPGLVPPSSAPLPAAPATAPAAAARAQEPLQDQGQRSAAAPHPAPDRPPRQHHGQL
LEQPQRGPGSRAHTPQSPHKHLGTQGAVTDKEKERPPSCCAAAGALLQHKSPSALGKGVL
SRRPENETVLHQFCCPAADACSDLASQSDGSCTQAGGGMEDSVVAAAAVAAGRPSAHAPK
AQAQELQEEEERPGAGAASPRAGPQHKASPGRQQPALATALCPHAPAASDYELSLDLKNK
QIEMLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLESRLPRRISLRKVRSPT
AESLAAEKALMEGYGLVGLPLVRSPSLPPTFAGTLTELEDSFTEQVQSLAKSIDDALSTW
SLKTMCSLRESGAYQLHQALQAAAGPPGLEAEGRAPESAGPGPGDDAAETPGLPPAHSGT
LMMAFRDVTVQIANQNISVSSSTALSVANCLGAQTVQAPAEPAAGKAEQGETSGREAPEA
PAVGREDASAEDSCAEAAASGAADGATAPKTEEEEEEEETAEVGRGAEAEAGDLEQLSSS
STSTKSAKSGSEASASASKDALQAMILSLPRYHCENPASCKSPTLSTDTLRKRLYRIGLN
LFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCV
VDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIF
ILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGIYERIQQKELK
SNEDHVTYVTKVEKSIVGMKTVLSVPHRRLVCCSRLFEVTDVNKLQKQAAHQREVFLFND
LLVILKLCPKKKSSSTYTFCKSVGLLGMQFQLFENEYYSHGITLVTPLSGSEKKQVLHFC
ALGSDEMQKFVEDLKESIAEVTELEQIRIEWELEKQQGTKTLSFKPCGAQGDPQSKQGSP
TAKREAALRERPAESTVEVSIHNRLQTSQHNSGLGAERGAPVPPPDLQPSPPRQQTPPLP
PPPPTPPGTLVQCQQIVKVIVLDKPCLARMEPLLSQALSCYTSSSSDSCGSTPLGGPGSP
VKVTHQPPLPPPPPPYNHPHQFCPPGSLLHGHRYSSGSRSLV
NT seq 3549 nt   +upstreamnt  +downstreamnt
atggagagcctgctggagaatccggtgcgcgccgtgctctacctcaaggagctcacggcc
atcgtgcagaaccagcagagcctcatccacacccagcgagagcgtatcgacgagctggag
cggcggctggacgagctgagcgctgagaaccgcagcctgtgggagcaccagcagctgctg
caagcccagcctccgcccgggctcgtccccccgtcatcggccccgctgccggccgctccg
gccaccgctcctgccgccgccgccagggcccaggaacctctccaggaccagggacagcgc
tcagcagccgcgccgcatcccgcgcccgatcggccgccgcgtcagcaccacggacagctc
ctggagcagccccagcggggccctggcagcagggctcacacaccccagtcgccccacaag
catctggggacacaaggggccgtgactgacaaggagaaggagcgtcccccgagttgctgc
gctgctgccggagccctccttcagcacaaatccccctccgccctcggcaagggcgtcctg
agcaggagacctgagaatgagaccgtgctgcaccagttctgctgcccagccgccgacgcc
tgctccgacctggcctcccaaagtgatggctcctgcacccaggccggtgggggcatggag
gactccgtggtggcagcggcggcggtggcagccggcagacccagtgcccatgccccgaag
gctcaagcccaggagctgcaggaggaggaggagcggccgggggcaggggctgcctcccca
agggctggcccccagcacaaggcctcccccggccggcagcagcctgccctggcgacggcg
ctgtgcccccacgcccctgccgcctccgattacgaactctcccttgacctaaagaataaa
cagattgaaatgctagaacataagtacggcggtcacctggtgtcccggcgcgccgcttgc
accatccaaaccgccttccgccaataccagctcagcaagaacttcgagaaaatccgcaac
tcgcttctggagagccgcctgccacggcggatctccctgcgcaaggtgcggtcacccacg
gccgagagcctggcggccgagaaagcgctcatggagggctacggcctcgtggggctgccg
ctggtgcgctcgccctccctgccgcccaccttcgcaggcaccctcaccgagctggaggac
tccttcaccgagcaggtgcaatccctggccaagtccatcgacgacgcgctcagcacgtgg
agcctcaagaccatgtgctccctgcgggagagtggcgcttaccagctccaccaggccctg
caggcggccgcggggcccccaggcctggaggccgaggggcgggcgccggagagcgcgggc
cccgggcccggggatgacgccgcggagacccccggcctgcccccggcccacagcgggacc
ctcatgatggctttccgggacgtcacggtgcagatcgccaaccagaacatatccgtctcc
tcctccacggctctgtcggtggccaactgcctgggcgctcagacggtccaggcccccgca
gagcccgcggcgggcaaggccgagcagggcgagacctctgggcgggaggccccggaagcc
cccgccgtgggccgggaggacgcgtcagccgaggactcatgcgcagaggctgcggctagt
ggggcggcggatggggccacagcccccaaaacagaggaggaagaggaggaggaggagacg
gcggaggtggggagaggggccgaggccgaggcaggcgacttggagcagctgagcagcagc
agcacgtccaccaagtccgccaagtcaggctcggaggcgtcggcctccgcctccaaggac
gccctgcaggccatgatcctgagcctgccgcgctaccactgcgagaacccagccagctgc
aagtcgcccacgctctccaccgacaccctgcgcaagcggctctaccgcatcggcctcaac
ctcttcaacataaaccccgacaagggcatccagttcctgatctcacgcggcttcatcccg
gacacccccatcggtgtggcccatttcctcctccagcgaaagggcctcagccgccagatg
attggagagttcctgggcaacagcaagaagcagttcaaccgcgacgtgctggactgcgtg
gtggacgagatggacttctccagcatggagctggacgaggccctgcgcaagttccaggca
cacatccgtgtgcagggggaggctcagaaggtggagcggctcattgaggccttcagccag
cgctactgcatgtgcaaccccgaagtggttcagcagttccacaaccccgacaccatcttc
atcctcgccttcgccatcatcctcctcaacaccgacatgtacagccccaacatcaagcct
gaccggaagatgatgctggaggacttcatccgaaaccttcgaggtgtggacgatggcgct
gacatccccagggagctggtggtaggcatctatgagaggatacagcagaaggagctcaag
tccaatgaggaccacgtcacgtacgtcaccaaggtggagaagtccattgtgggcatgaag
acagtgctgtccgtgccccaccgccgcctggtgtgctgcagccggctcttcgaggtgacg
gatgtgaacaagctgcagaagcaggcagcgcatcagagggaggtgttcctcttcaatgac
ctgctggtgattctcaaactttgcccgaagaagaagagctcctccacgtacaccttttgc
aagtcagttggcctgctgggcatgcagttccagctctttgagaacgagtattactctcat
ggcatcacactggtgaccccgctctcgggctccgagaagaagcaggtgctgcatttctgt
gccctgggctcggacgagatgcagaagttcgtggaggacctgaaggagtccattgctgag
gtgacggagctggagcagatccgaatagagtgggagctggagaagcagcagggaacaaag
acactctccttcaagccctgcggagcccagggggacccacagtcaaagcaaggatcgccg
acagccaaaagggaagccgcgctcagggagaggccggcggagagcacggtggaggtgtca
attcacaacaggcttcaaacgtcccagcacaactccgggctgggggccgagaggggagcg
ccggtgccgccgccagacctgcagcctagccccccgagacagcagaccccaccactgccg
ccgccgccacccacgcccccgggcaccctggtgcagtgccagcaaattgtcaaggtcatt
gtcctggacaagccctgcctggcccgcatggagcccctgctgagccaggctctctcctgc
tacacctcgtcgtcctctgactcctgcggctccacacccctgggcggtcccggctctccg
gtcaaggtcacccaccagcctccgctgcccccgcccccacccccctacaaccaccctcac
cagttctgtcccccaggctccctgctgcacgggcaccgctactccagtggctcaaggagc
ctggtgtag

KEGG   Homo sapiens (human): 5662
Entry
5662              CDS       T01001                                 
Symbol
PSD, EFA6, EFA6A, PSD1, TYL
Name
(RefSeq) pleckstrin and Sec7 domain containing
  KO
K12494  PH and SEC7 domain-containing protein
Organism
hsa  Homo sapiens (human)
Pathway
hsa04144  Endocytosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    5662 (PSD)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    5662 (PSD)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Arf GTPases and associated proteins
   Arf associated proteins
    5662 (PSD)
SSDB
Motif
Pfam: Sec7 PH_9 PH
Other DBs
NCBI-GeneID: 5662
NCBI-ProteinID: NP_001257894
OMIM: 602327
HGNC: 9507
Ensembl: ENSG00000059915
Pharos: A5PKW4(Tbio)
UniProt: A5PKW4
LinkDB
Position
10:complement(102402619..102419946)
AA seq 1024 aa
MAQGAMRFCSEGDCAISPPRCPRRWLPEGPVPQSPPASMYGSTGSLLRRVAGPGPRGREL
GRVTAPCTPLRGPPSPRVAPSPWAPSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAP
GGLSRSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAP
PQVGADGLYSSLPNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKW
EFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETD
IDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGE
EDVDDEVFEASEGARPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSY
TSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQ
RGEEEEAEARAKLAPGREPPSPCHSEDSLGLGAAPLGSEPPLSQLVSDSDSELDSTERLA
LGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVF
TGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLL
NTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRS
LSELADPNPKVIKRISGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGK
RGWKSFHGILKGMILYLQKEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLR
TADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQ
EEQVRTHEAKLKAMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLR
VKLKAGSEELDAVEAALAQAGSTEDGLPPSHSSPSLQPKPSSQPRAQRHSSEPRPGAGSG
RRKP
NT seq 3075 nt   +upstreamnt  +downstreamnt
atggcccagggtgccatgcgcttctgctcggaaggcgactgtgccatctccccaccacga
tgcccacgccgctggctccccgaaggcccggtgccccagagccccccagccagcatgtat
ggcagcacaggctccttgctacggcgagtggcaggtccaggtcctcgaggccgggaactg
ggacgtgtgacagcaccctgtacacctctgcgtggccccccctcaccccgtgttgctccc
tcaccctgggcaccctcttcacccactgggcagcccccacccggggcccagagctctgtg
gtcatcttccgctttgtggagaaggccagtgtgaggccactgaatgggctacctgctcca
gggggcttgagtcggagctgggatctgggtggggtttctcctcccaggcccaccccagcc
cttgggcctggctccaaccggaagttacggctggaagcatccacatcagacccactcccc
gccagaggaggctcggccctacctggcagccggaaccttgtacatgggccgccagcccca
ccccaggttggagcagatggcctttactcctctctccccaatgggctggggggcccccct
gagcgcctggccacactcttcggaggacctgctgacactggattcctgaaccagggggat
acctggtcctccccccgggaagtctcctctcatgcccagagaatcgctagagccaaatgg
gaattcttctatggctccttggacccccccagctcaggtgctaagcccccagagcaggcc
cccccatctccacctggggtgggctcaaggcagggctctggggtggctgtggggcgagca
gccaagtactccgagacagacctggacacggtgcccctgaggtgctaccgcgagactgac
atcgatgaggtgctggctgagcgggaggaggccgactcggccatcgaaagtcagcccagc
tctgagggcccaccaggcactgcctacccacctgccccacggcccggcccactccctggc
cctcatcccagcctcggcagtggcaatgaggatgaggacgacgatgaggcaggtggggaa
gaagatgtggacgacgaggtgtttgaggcctctgaaggggcccggccagggagccggatg
cctctcaagtcacctgtgccctttctacctgggacgagcccctcggctgatgggcctgac
tctttcagttgtgtgttcgaagccatcctggagtcacaccgggccaaaggcacctcctat
accagcctcgcctcgctggaggccttggcctcacctggcccaacccagagccccttcttc
acctttgagctgcctccccaaccccctgcaccccggcccgacccaccagctcccgcccca
cttgcccctcttgaaccggattctggtaccagctctgctgctgatggtccttggacacag
agaggggaggaggaggaggcagaggccagagccaagctggccccagggagggagccccct
agtccctgccactcagaggacagccttgggctgggggcagcaccccttggcagcgaacca
cccctgagccagctggtgtccgactcagactcagagctggacagcacagagcggctggcc
ctgggaagcacagacaccttgtccaatgggcagaaagcggacctggaggctgcgcagcgc
ctggccaagaggctgtaccgactagatggcttcaggaaggccgatgtggcccggcacctg
ggcaagaacaatgacttcagcaaactggtggctggggagtacctcaagttctttgtcttc
acgggcatgactctggaccaagctctcagggtgtttctgaaggagctggccttaatgggt
gagacccaggaacgagagcgcgtgctggcccacttctcccagcgatacttccagtgcaat
cctgaagccctgtcctcagaggacggcgcccacacgctgacctgtgcgctcatgctgctc
aacacggatctccacggccataacatcgggaagcgcatgacctgcggggacttcatcggg
aacctggagggcctcaatgatggcggcgacttccctagggagctgctcaaggccttgtac
agctccatcaagaatgagaagctgcagtgggccatagacgaggaggagctgagacgctct
ctgtctgagttggccgaccccaaccccaaggtcatcaagcggatcagcgggggcagtggc
agtggctccagccctttcctggacctgactcccgagcctggggctgccgtctacaagcac
ggggccctggtgcgaaaggtgcacgcagaccctgactgcaggaagacacctcggggcaag
cggggctggaagagcttccacgggatcctcaagggcatgatcctctacctgcagaaggag
gagtacaagcctgggaaggccctttcagagacggagctcaagaatgccatcagcatccac
catgccctggccactcgtgccagtgactacagcaagaggccccacgtcttctacctgcgc
acagctgactggcgggtcttcctcttccaggccccgagcctggagcagatgcagtcctgg
atcactcgcatcaatgtagtagccgctatgttctctgcgccccccttcccagctgctgtt
agctcccaaaagaagttcagccgccctctcctgcccagcgctgccacccgcctctcccag
gaggagcaggtgcggacccacgaggccaagctgaaggccatggcaagtgagctgcgggag
caccgggccgcccagctgggcaagaagggccggggcaaggaggctgaagagcagcggcag
aaggaggcctacctggagtttgagaaatcccgctacagcacctatgcagcgctgcttcgg
gtcaagctgaaggcaggcagtgaggagctggatgcagtggaggcagcactggcccaggcc
gggagcacagaggatggactccctccttctcactccagtccctccctgcagcccaaaccc
tccagccagccccgggctcagcgtcacagctcagagcctcggccaggggcaggcagtggg
cggcggaagccctga

KEGG   Homo sapiens (human): 84249
Entry
84249             CDS       T01001                                 
Symbol
PSD2, EFA6C
Name
(RefSeq) pleckstrin and Sec7 domain containing 2
  KO
K12494  PH and SEC7 domain-containing protein
Organism
hsa  Homo sapiens (human)
Pathway
hsa04144  Endocytosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    84249 (PSD2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    84249 (PSD2)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Arf GTPases and associated proteins
   Arf associated proteins
    84249 (PSD2)
SSDB
Motif
Pfam: Sec7 PH_9 PH Borrelia_orfA PH_11 TEX13B_C
Other DBs
NCBI-GeneID: 84249
NCBI-ProteinID: NP_115665
OMIM: 620656
HGNC: 19092
Ensembl: ENSG00000146005
Pharos: Q9BQI7(Tdark)
UniProt: Q9BQI7
LinkDB
Position
5:139742475..139844466
AA seq 771 aa
MEEDKLLSAVPEEGDATRDPGPEPEEEPGVRNGMASEGLNSSLCSPGHERRGTPADTEEP
TKDPDVAFHGLSLGLSLTNGLALGPDLNILEDSAESRPWRAGVLAEGDNASRSLYPDAED
PQLGLDGPGEPDVRDGFSATFEKILESELLRGTQYSSLDSLDGLSLTDESDSCVSFEAPL
TPLIQQRARDSPEPGAGLGIGDMAFEGDMGAAGGDGELGSPLRRSISSSRSENVLSRLSL
MAMPNGFHEDGPQGPGGDEDDDEEDTDKLLNSASDPSLKDGLSDSDSELSSSEGLEPGSA
DPLANGCQGVSEAAHRLARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLT
LDGALRTFLKAFPLMGETQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLLNTDL
HGHNIGKKMSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDELRKSLSEL
VDDKFGTGTKKVTRILDGGNPFLDVPQALSATTYKHGVLTRKTHADMDGKRTPRGRRGWK
KFYAVLKGTILYLQKDEYRPDKALSEGDLKNAIRVHHALATRASDYSKKSNVLKLKTADW
RVFLFQAPSKEEMLSWILRINLVAAIFSAPAFPAAVSSMKKFCRPLLPSCTTRLCQEEQL
RSHENKLRQLTAELAEHRCHPVERGIKSKEAEEYRLKEHYLTFEKSRYETYIHLLAMKIK
VGSDDLERIEARLATLEGDDPSLRKTHSSPALSQGHVTGSKTTKDATGPDT
NT seq 2316 nt   +upstreamnt  +downstreamnt
atggaggaggacaagctcttatctgcagtgcctgaggaaggcgatgccacccgtgacccc
ggtccagagcctgaagaggagccaggggtccggaatgggatggccagtgagggcctgaac
agcagcctctgcagcccagggcacgagcgaaggggcaccccagcggacactgaggaaccc
acgaaggacccagatgtggccttccatggcctcagccttggcctctctctcaccaatggc
ctagccctggggccagacttgaacattctggaagattcagcggagtccaggccctggagg
gctggcgtgctggcagagggggacaatgcttccaggagcctctacccagatgctgaggac
cctcagctggggttggatggtcccggggagccagatgtgcgggatggcttcagcgccacg
tttgagaagattctggagtcagagctgctgcggggcacccagtacagcagcctcgactcc
ctagacgggctgagcctcacggatgagagcgacagctgcgtcagcttcgaggcccccctc
acacccctcatccagcagcgggcccgtgacagccctgagccaggggctgggttgggcatt
ggggacatggcgtttgagggggacatgggggcagctggtggtgatggggagctgggcagc
cccctgcggcgctccatctccagcagccgctctgagaatgtcctgagccgcctgtctctc
atggccatgcccaatggattccatgaagatggccctcagggcccagggggggatgaggat
gatgatgaggaggacacggacaagttgctgaactcagccagtgaccccagcctgaaggat
ggcctgtcagactcagactctgagctcagcagctcggaggggttggagcctggtagtgca
gaccctctggccaacgggtgccagggggtcagtgaagctgctcatcggctggcacgccgt
ctctaccacctcgagggcttccagcgctgtgatgtggcccggcagctgggcaagaacaac
gagtttagcaggctggtggccggggagtacctcagtttcttcgacttctcgggcttgact
ctggacggagcactcagaacattcttgaaggccttcccgctgatgggggagacacaagag
cgtgagcgggtcctcacacacttctcccgccggtactgccagtgcaaccctgatgacagc
acttcggaagatgggatccacacgctcacctgtgccctgatgctgctcaacacggacctg
cacggccacaacattggcaaaaagatgtcctgtcagcaattcattgccaacttggaccag
ctgaatgatggccaagactttgccaaagacctgctgaagaccctttacaactccatcaag
aatgaaaagctggaatgggccattgatgaggatgagctgaggaaatccctgtctgagctg
gtggatgacaagttcgggacaggcacgaagaaggtgacgcgaatcctggatggtggcaac
cccttcctggatgtcccacaggcgctcagtgccaccacctacaagcacggcgtcctgacc
cggaagactcacgctgacatggatggcaagaggacgccccgtgggaggcgtggctggaag
aaattctacgcagtgctcaaagggaccatcctgtacctgcagaaggatgagtacaggcct
gacaaagctctatcggagggtgacctgaagaacgccattcgcgtgcatcacgctctggcc
accagggcctctgactacagcaagaagtccaacgtgctgaagcttaagacagccgactgg
agggtattcctcttccaggcaccgagcaaggaagaaatgctgtcctggatcctcaggatc
aacctggtggcagccatcttctctgccccggccttcccagccgctgtcagctccatgaag
aagttctgtcggcccctgctgccctcctgcaccacccgcctctgccaggaggagcaactg
cggtctcatgagaataagttgaggcagctgactgcggagctggccgaacacaggtgtcac
ccagtcgagaggggcatcaagtccaaggaggccgaggagtaccggttgaaggagcactat
ctcaccttcgagaaaagccgttatgagacctatatccacctcctggctatgaaaatcaaa
gtgggctcagatgatctggagcggattgaggcccggctggccactctggaaggggatgac
ccttctctccggaagacacattcaagccctgccctcagccagggccatgtgactggcagc
aaaaccacaaaggatgccactgggcctgatacttag

KEGG   Homo sapiens (human): 8729
Entry
8729              CDS       T01001                                 
Symbol
GBF1, ARF1GEF, CMT2GG, CMTDI2, CMTDIA
Name
(RefSeq) golgi brefeldin A resistant guanine nucleotide exchange factor 1
  KO
K18443  golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04144  Endocytosis
Network
nt06180  Pathogenic Escherichia coli
  Element
N01293  COPI vesicle formation
Disease
H00264  Charcot-Marie-Tooth disease
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    8729 (GBF1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    8729 (GBF1)
Membrane trafficking [BR:hsa04131]
 Endosome - Golgi transport
  Arf GTPases and associated proteins
   Arf GTPase associated proteins
    8729 (GBF1)
SSDB
Motif
Pfam: Sec7 Sec7-like_HUS DUF1045 DUF758
Other DBs
NCBI-GeneID: 8729
NCBI-ProteinID: NP_004184
OMIM: 603698
HGNC: 4181
Ensembl: ENSG00000107862
Pharos: Q92538(Tbio)
UniProt: Q92538
LinkDB
Position
10:102230643..102382896
AA seq 1859 aa
MVDKNIYIIQGEINIVVGAIKRNARWSTHTPLDEERDPLLHSFGHLKEVLNSITELSEIE
PNVFLRPFLEVIRSEDTTGPITGLALTSVNKFLSYALIDPTHEGTAEGMENMADAVTHAR
FVGTDPASDEVVLMKILQVLRTLLLTPVGAHLTNESVCEIMQSCFRICFEMRLSELLRKS
AEHTLVDMVQLLFTRLPQFKEEPKNYVGTNMKKLKMRAGGMSDSSKWKKQKRSPRPPRHM
TKVTPGSELPTPNGTTLSSNLTGGMPFIDVPTPISSASSEAASAVVSPSTDSGLEFSSQT
TSKEDLTDLEQPGSPGYSTATEPGSSELGVPEQPDLQEGTHVEKSQSASVESIPEVLEEC
TSPADHSDSASVHDMDYVNPRGVRFTQSSQKEGTALVPYGLPCIRELFRFLISLTNPHDR
HNSEVMIHMGLHLLTVALESAPVAQCQTLLGLIKDEMCRHLFQLLSIERLNLYAASLRVC
FLLFESMREHLKFQMEMYIKKLMEIITVENPKMPYEMKEMALEAIVQLWRIPSFVTELYI
NYDCDYYCSNLFEELTKLLSKNAFPVSGQLYTTHLLSLDALLTVIDSTEAHCQAKVLNSL
TQQEKKETARPSCEIVDGTREASNTERTASDGKAVGMASDIPGLHLPGGGRLPPEHGKSG
CSDLEEAVDSGADKKFARKPPRFSCLLPDPRELIEIKNKKKLLITGTEQFNQKPKKGIQF
LQEKGLLTIPMDNTEVAQWLRENPRLDKKMIGEFVSDRKNIDLLESFVSTFSFQGLRLDE
ALRLYLEAFRLPGEAPVIQRLLEAFTERWMNCNGSPFANSDACFSLAYAVIMLNTDQHNH
NVRKQNAPMTLEEFRKNLKGVNGGKDFEQDILEDMYHAIKNEEIVMPEEQTGLVRENYVW
NVLLHRGATPEGIFLRVPTASYDLDLFTMTWGPTIAALSYVFDKSLEETIIQKAISGFRK
CAMISAHYGLSDVFDNLIISLCKFTALSSESIENLPSVFGSNPKAHIAAKTVFHLAHRHG
DILREGWKNIMEAMLQLFRAQLLPKAMIEVEDFVDPNGKISLQREETPSNRGESTVLSFV
SWLTLSGPEQSSVRGPSTENQEAKRVALECIKQCDPEKMITESKFLQLESLQELMKALVS
VTPDEETYDEEDAAFCLEMLLRIVLENRDRVGCVWQTVRDHLYHLCVQAQDFCFLVERAV
VGLLRLAIRLLRREEISAQVLLSLRILLLMKPSVLSRVSHQVAYGLHELLKTNAANIHSG
DDWATLFTLLECIGSGVKPPAALQATARADAPDAGAQSDSELPSYHQNDVSLDRGYTSDS
EVYTDHGRPGKIHRSATDADVVNSGWLVVGKDDVDNSKPGPSRPGPSPLINQYSLTVGLD
LGPHDTKSLLKCVESLSFIVRDAAHITPDNFELCVKTLRIFVEASLNGGCKSQEKRGKSH
KYDSKGNRFKKKSKEGSMLRRPRTSSQHASRGGQSDDDEDEGVPASYHTVSLQVSQDLLD
LMHTLHTRAASIYSSWAEEQRHLETGGQKIEADSRTLWAHCWCPLLQGIACLCCDARRQV
RMQALTYLQRALLVHDLQKLDALEWESCFNKVLFPLLTKLLENISPADVGGMEETRMRAS
TLLSKVFLQHLSPLLSLSTFAALWLTILDFMDKYMHAGSSDLLSEAIPESLKNMLLVMDT
AEIFHSADARGGGPSALWEITWERIDCFLPHLRDELFKQTVIQDPMPMEPQGQKPLASAH
LTSAAGDTRTPGHPPPPEIPSELGACDFEKPESPRAASSSSPGSPVASSPSRLSPTPDGP
PPLAQPPLILQPLASPLQVGVPPMTLPIILNPALIEATSPVPLLATPRPTDPIPTSEVN
NT seq 5580 nt   +upstreamnt  +downstreamnt
atggtggataagaatatttacatcattcaaggggagattaacattgtggttggggccatc
aaacgaaatgcccgatggagcacccatacaccactggatgaagaacgggatcctctgctg
catagtttcggtcatctaaaggaggttttaaacagtataacagaactctcagaaattgag
cccaatgtattccttcgaccttttctggaagtgattcgctctgaagataccactggccct
atcactggactggcactcacctctgtcaacaagttcctgtcctatgcactcatagatccc
acccatgagggcacagcagagggcatggagaacatggcagatgctgtcacccatgctcgt
tttgtgggcacggatcctgccagtgatgaagttgtcctgatgaaaatccttcaggttcta
cggactctgctgctaaccccagtgggtgcccacctaaccaatgaatctgtgtgtgagatt
atgcagtcttgcttccggatctgctttgaaatgaggctcagtgagttattgagaaaatcc
gcagagcacactctcgtagacatggtgcagctgctcttcacaaggttacctcagtttaaa
gaagaacccaagaactatgtggggaccaacatgaagaagctgaaaatgagagccggaggc
atgagtgattcatccaaatggaagaaacagaagagatcccctcggcccccacgccatatg
accaaagtcacaccaggttcagagctgcccactcccaatggaaccaccttatcatctaac
ctcactggtggcatgcccttcattgatgtgcccactcccatctcctctgcaagttcagaa
gctgcctcagcagtggtcagtccctctacagacagtggcctggaattctcctcccaaacc
acttccaaggaagaccttactgatctagagcaacctggctctccagggtacagcacagct
acagagcctggaagcagtgagctaggtgttcccgagcagcctgacctccaggaagggacc
catgtggaaaagtcccagtcagcatctgtggagtccatccctgaagtgttagaggagtgc
acgtcccctgccgaccactctgactctgcctctgtccatgacatggattacgtcaatccc
cggggcgtgcgctttacacagtcctcccagaaagaaggcacagctttggtcccctatggt
cttccctgcatccgcgagctcttccgcttcctcatctccctcaccaatccacacgaccgc
cataactcagaggttatgattcacatgggactgcatttgctgacagtggcccttgagtca
gcccctgtagcccagtgccagaccctcttgggcctcatcaaggatgagatgtgccgtcac
ttattccagctactcagcatagagcgactaaacctttatgctgcttccctgcgagtatgc
ttcctactgtttgagagcatgcgagagcacctcaagttccaaatggagatgtacatcaaa
aagcttatggagatcatcactgtggagaaccccaagatgccttatgagatgaaggagatg
gcactggaggccattgtgcagctctggcgcatccccagctttgtcacagagctctacatc
aactatgattgtgactactactgttccaacctctttgaggaactcacaaagctgctgtcc
aagaatgccttccctgtgtctggtcaactctatacaacacacctactatctcttgatgcc
ctattgacagtgattgacagcaccgaggcccactgccaggctaaagtcctcaacagcctc
acccagcaagagaagaaggagacagccagaccaagctgtgagatagtagatggcacccga
gaagctagcaatactgagagaactgccagcgatgggaaagctgtaggcatggcctcagac
atcccaggcctgcatctgccaggtggagggcggctgccaccagaacatgggaaatcagga
tgcagtgatctggaggaagctgttgactctggggctgacaaaaagtttgcccggaagcca
ccccgattttcctgtctcctgccagatccacgggaactaattgaaattaaaaacaaaaag
aagctgctaatcactggcacagagcagttcaatcagaaaccaaagaaggggattcagttt
ctgcaagagaaaggcctcctcaccatcccaatggacaacacagaggttgctcagtggctc
cgagagaaccctcggctggacaagaagatgattggagagtttgtgagtgaccgcaaaaac
attgacctgttggagagctttgtgagcaccttcagttttcagggtctgcgactggacgaa
gccctccgcctctacctggaagccttccgtttgcctggggaagcaccagtcatccagagg
ttgctggaggcattcacagagcgttggatgaattgtaatggctccccatttgccaatagc
gatgcctgcttttccctggcctatgctgtcatcatgcttaatactgaccagcacaaccac
aatgttcgtaaacagaatgcacccatgaccctggaggagtttcgcaaaaatctgaaaggt
gtgaatggaggcaaggactttgagcaagacatcctggaggacatgtaccatgccatcaag
aatgaggaaattgtaatgcctgaggagcagacaggcttggttcgggagaactatgtgtgg
aatgtgctgcttcatcgaggtgccacccctgagggcatattcctgcgtgtgcctactgcc
agctatgatcttgacctcttcaccatgacctggggccccactattgctgctctctcttat
gtctttgacaaaagccttgaggagacaatcatccagaaagccatctcaggcttcaggaag
tgcgccatgatctccgcccactatggcctcagcgatgtgtttgacaatctcatcatctct
ctatgcaaattcacagctctcagcagtgagtctattgagaacctgcccagtgtatttgga
agcaaccctaaagcccatattgcagccaagacagtattccatttggcccatcgtcatggt
gacatcctgcgggagggctggaagaatatcatggaggccatgctgcagctcttccgagcc
caactactgcccaaggctatgatagaggtagaagatttcgtggatcccaatggcaagatc
tctctacagcgggaagagacaccatcaaaccgaggagagtcaacagtgctgagctttgtg
agctggctaacactgagtggtcctgagcagtctagtgttcggggcccatccactgaaaac
caagaggccaagagagtggccttagagtgtataaagcaatgtgacccagaaaaaatgatc
acagaaagcaagttcctccagctggagtcactacaggagctcatgaaggctctggtctca
gtgacaccagatgaagagacatatgatgaggaagatgctgctttctgcctagagatgctg
ctaaggattgtgttggagaacagggatcgtgtgggctgtgtgtggcagactgttcgagac
catctataccacctctgtgttcaggcacaagatttctgcttccttgtggagcgggcagtg
gtggggttgctacgcctggccattcggcttctccggagagaagagatcagtgctcaggtg
ctgctctccctgcgcattttgctactgatgaagcccagtgtgctatcccgagtcagccac
caggttgcgtatgggctccatgaactcctgaagaccaatgcagccaacatccactcaggt
gatgactgggccacactcttcacactgctggagtgcatcggctcaggtgtgaagcctcca
gctgctctgcaggccacagccagggcagatgcacctgatgccggggcccagtcagatagt
gagctcccatcctaccatcagaatgacgtgagcctggatcgagggtacacttccgactca
gaggtctacactgaccatggcaggccgggcaagatacaccgatcagccacagatgccgat
gtggtcaacagtggttggttagtggttgggaaggatgacgttgataactccaagccaggg
cccagccgcccaggcccttcacccctgatcaatcaatacagcctaacagtgggactggat
ttggggccacacgacactaagtctctgcttaagtgtgtggaatcgctgtccttcattgtg
cgtgatgctgcccacatcacacctgacaactttgagctctgcgtcaagactctccggatc
tttgtggaggccagtctgaatggcggatgcaagtcccaggagaaacgtggcaagagtcac
aaatatgacagcaaagggaaccgcttcaagaagaaatccaaagagggatcaatgcttcgc
cggcctcgaacctccagccaacatgcctctcggggcgggcagagtgatgatgatgaggac
gaaggcgtgcctgccagctaccatacggtgtctttacaggtcagtcaggacttgctagac
ctgatgcacaccctgcacacgcgggcagcctctatctacagctcatgggcggaggagcaa
cgccacctggagacaggtggccagaagattgaagctgattctcgcaccctctgggcccac
tgctggtgccctttactgcagggtattgcctgcctgtgctgcgatgcccggcgccaggta
cggatgcaggcactgacctatctgcagcgagcactacttgtacatgatctgcaaaagcta
gatgccctggaatgggagtcctgttttaacaaggtgctgtttcctctacttaccaagctc
ttggagaacatcagccctgcagatgtgggtgggatggaggagacccggatgagggcttcc
acattgctctctaaggtcttcctgcagcacctgtctccactgctgtcactctctaccttt
gcggccctctggctcaccatcttggacttcatggacaagtacatgcacgcaggctccagc
gacttactgtcagaggcgatccctgagtctctgaagaacatgcttctggtgatggacaca
gcggagattttccacagtgcagatgcacggggaggcggcccctcggccctctgggagatc
acctgggaacgcattgactgttttctccctcacctacgagatgaactcttcaagcagacc
gtcatccaggaccccatgcccatggagcctcaaggccaaaagcctctcgcctcagcccac
ctgacttccgctgctggcgacactaggacacctggccatccaccgcccccagagattcca
tctgagctgggggcctgtgactttgagaagcccgagagcccccgagccgccagcagcagc
tccccaggatcaccagtggcctcaagccccagcaggctgagccccacccccgacgggcct
ccacccttggctcagcccccactgatcctgcagcccttggcctccccactgcaggtgggc
gtgccacctatgactctgcccatcatcctcaaccctgcgctcatcgaggccacctcacca
gtgcccctcctggccacaccccgccccacagatcccatacccacctctgaggtcaactaa

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