KEGG   Homo sapiens (human): 10681
Entry
10681             CDS       T01001                                 
Symbol
GNB5, GB5, HG2E, IDDCA, LADCI, LDMLS1, LDMLS2, gbeta5
Name
(RefSeq) G protein subunit beta 5
  KO
K04539  guanine nucleotide-binding protein subunit beta-5
Organism
hsa  Homo sapiens (human)
Pathway
hsa04014  Ras signaling pathway
hsa04062  Chemokine signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04371  Apelin signaling pathway
hsa04713  Circadian entrainment
hsa04723  Retrograde endocannabinoid signaling
hsa04724  Glutamatergic synapse
hsa04725  Cholinergic synapse
hsa04726  Serotonergic synapse
hsa04727  GABAergic synapse
hsa04728  Dopaminergic synapse
hsa04926  Relaxin signaling pathway
hsa05032  Morphine addiction
hsa05034  Alcoholism
hsa05163  Human cytomegalovirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06167  Human cytomegalovirus (HCMV)
nt06224  CXCR signaling (cancer)
nt06530  PI3K signaling
nt06533  Chemokine signaling
  Element
N00152  CXCR-GNB/G-ERK signaling pathway
N00153  CCR/CXCR-GNB/G-PI3K-RAC signaling pathway
N00154  CXCR-GNB/G-PI3K-AKT signaling pathway
N00157  KSHV vGPCR to GNB/G-ERK signaling pathway
N00158  KSHV vGPCR to GNB/G-PI3K-AKT signaling pathway
N00178  KSHV vGPCR to GNB/G-PI3K-JNK signaling pathway
N00399  CCR2-GNB/G-PI3K-NFKB signaling pathway
N00400  HCMV US28 to GNB/G-PI3K-NFKB signaling pathway
N00408  LPAR-GNB/G-Rho signaling pathway
N00409  HCMV UL33 to GNB/G-Rho signaling pathway
N00413  CXCR4-GNB/G-PLCB-PKC signaling pathway
N00428  CCR5-GNB/G-PLCB/G-PKC signaling pathway
N00433  CXCR4-GNB/G-RAC signaling pathway
N00434  HIV gp120 to CXCR4-GNB/G-RAC signaling pathway
N01657  GPCR-PI3K signaling pathway
N01746  CCR/CXCR-GNB/G-PI3K signaling pathway
N01769  CCR5-GNB/G-PLCB/G signaling pathway
N01770  CCR2-GNB/G-PI3K signaling pathway
N01771  CXCR4-GNB/G signaling pathway
Disease
H02463  Syndromic intellectual developmental disorder
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    10681 (GNB5)
   04371 Apelin signaling pathway
    10681 (GNB5)
   04151 PI3K-Akt signaling pathway
    10681 (GNB5)
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    10681 (GNB5)
  09152 Endocrine system
   04926 Relaxin signaling pathway
    10681 (GNB5)
  09156 Nervous system
   04724 Glutamatergic synapse
    10681 (GNB5)
   04727 GABAergic synapse
    10681 (GNB5)
   04725 Cholinergic synapse
    10681 (GNB5)
   04728 Dopaminergic synapse
    10681 (GNB5)
   04726 Serotonergic synapse
    10681 (GNB5)
   04723 Retrograde endocannabinoid signaling
    10681 (GNB5)
  09159 Environmental adaptation
   04713 Circadian entrainment
    10681 (GNB5)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    10681 (GNB5)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    10681 (GNB5)
   05163 Human cytomegalovirus infection
    10681 (GNB5)
   05167 Kaposi sarcoma-associated herpesvirus infection
    10681 (GNB5)
  09165 Substance dependence
   05032 Morphine addiction
    10681 (GNB5)
   05034 Alcoholism
    10681 (GNB5)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    10681 (GNB5)
   04031 GTP-binding proteins [BR:hsa04031]
    10681 (GNB5)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   10681 (GNB5)
GTP-binding proteins [BR:hsa04031]
 Heterotrimeric G-proteins
  Beta Subunits
   Beta [OT]
    10681 (GNB5)
SSDB
Motif
Pfam: WD40 ANAPC4_WD40 NBCH_WD40 WD40_like DUF2538
Other DBs
NCBI-GeneID: 10681
NCBI-ProteinID: NP_057278
OMIM: 604447
HGNC: 4401
Ensembl: ENSG00000069966
UniProt: O14775
Structure
LinkDB
Position
15:complement(52115100..52191392)
AA seq 395 aa
MCDQTFLVNVFGSCDKCFKQRALRPVFKKSQQLSYCSTCAEIMATEGLHENETLASLKSE
AESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRI
VSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDK
NENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADV
LCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGS
DDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRV
SILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA
NT seq 1188 nt   +upstreamnt  +downstreamnt
atgtgtgatcagacctttctcgttaatgtatttggctcatgtgacaaatgtttcaaacaa
cgagctctgagaccagttttcaagaagtctcaacaactcagctactgttcaacatgtgca
gaaattatggcaaccgaggggctgcacgagaacgagacgctggcgtcgctgaagagcgag
gccgagagcctcaagggcaagctggaggaggagcgagccaagctgcacgatgtggagctg
caccaggtggcggagcgggtggaggccctggggcagtttgtcatgaagaccagaaggacc
ctcaaaggccacgggaacaaagtcctgtgcatggactggtgcaaagataagaggaggatc
gtgagctcgtcacaggatgggaaggtgatcgtgtgggattccttcaccacaaacaaggag
cacgcggtcaccatgccctgcacgtgggtgatggcatgtgcttatgccccatcgggatgt
gccattgcttgtggtggtttggataataagtgttctgtgtaccccttgacgtttgacaaa
aatgaaaacatggctgccaaaaagaagtctgttgctatgcacaccaactacctgtcggcc
tgcagcttcaccaactctgacatgcagatcctgacagcgagcggcgatggcacatgtgcc
ctgtgggacgtggagagcgggcagctgctgcagagcttccacggacatggggctgacgtc
ctctgcttggacctggccccctcagaaactggaaacaccttcgtgtctgggggatgtgac
aagaaagccatggtgtgggacatgcgctccggccagtgcgtgcaggcctttgaaacacat
gaatctgacatcaacagtgtccggtactaccccagtggagatgcctttgcttcagggtca
gatgacgctacgtgtcgcctctatgacctgcgggcagatagggaggttgccatctattcc
aaagaaagcatcatatttggagcatccagcgtggacttctccctcagtggtcgcctgctg
tttgctggatacaatgattacactatcaacgtctgggatgttctcaaagggtcccgggtc
tccatcctgtttggacatgaaaaccgcgttagcactctacgagtttcccccgatgggact
gctttctgctctggatcatgggatcataccctcagagtctgggcctaa

KEGG   Homo sapiens (human): 2778
Entry
2778              CDS       T01001                                 
Symbol
GNAS, AHO, C20orf45, GNAS1, GPSA, GSA, GSP, NESP, PITA3, POH, SCG6, SgVI
Name
(RefSeq) GNAS complex locus
  KO
K04632  guanine nucleotide-binding protein G(s) subunit alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa01522  Endocrine resistance
hsa04015  Rap1 signaling pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04540  Gap junction
hsa04611  Platelet activation
hsa04713  Circadian entrainment
hsa04714  Thermogenesis
hsa04724  Glutamatergic synapse
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
hsa04730  Long-term depression
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04911  Insulin secretion
hsa04912  GnRH signaling pathway
hsa04913  Ovarian steroidogenesis
hsa04915  Estrogen signaling pathway
hsa04916  Melanogenesis
hsa04918  Thyroid hormone synthesis
hsa04921  Oxytocin signaling pathway
hsa04922  Glucagon signaling pathway
hsa04923  Regulation of lipolysis in adipocytes
hsa04924  Renin secretion
hsa04925  Aldosterone synthesis and secretion
hsa04926  Relaxin signaling pathway
hsa04927  Cortisol synthesis and secretion
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04934  Cushing syndrome
hsa04935  Growth hormone synthesis, secretion and action
hsa04961  Endocrine and other factor-regulated calcium reabsorption
hsa04962  Vasopressin-regulated water reabsorption
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion
hsa04972  Pancreatic secretion
hsa04976  Bile secretion
hsa05012  Parkinson disease
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05032  Morphine addiction
hsa05034  Alcoholism
hsa05110  Vibrio cholerae infection
hsa05142  Chagas disease
hsa05146  Amoebiasis
hsa05163  Human cytomegalovirus infection
hsa05165  Human papillomavirus infection
hsa05200  Pathways in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05414  Dilated cardiomyopathy
Network
nt06167  Human cytomegalovirus (HCMV)
nt06234  cAMP signaling (cancer)
nt06310  CRH-ACTH-cortisol signaling
nt06318  CaSR-PTH signaling
nt06322  TRH-TSH-TH signaling
nt06323  KISS1-GnRH-LH/FSH-E2 signaling
nt06324  GHRH-GH-IGF signaling
nt06325  Hormone/cytokine signaling
nt06360  Cushing syndrome
nt06529  Thermogenesis
  Element
N00288  PTH-PTH1R-PKA signaling pathway
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00321  Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00324  CRHR-PKA-ACTH signaling pathway
N00326  Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway
N00327  Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway
N00410  DRD1-GNAS-AC-PKA signaling pathway
N00411  HCMV UL33 to GNAS-AC-PKA signaling pathway
N00782  TSH-TG signaling pathway
N00885  LHCGR-GNAS-PKA signaling pathway
N00910  GHRHR-PKA-GH signaling pathway
N00915  AVP-V2R-PKA signaling pathway
N00922  FSHR-GNAS-PKA signaling pathway
N01345  EP/NE-ADRB-cAMP signaling pathway
N01346  Nicotine/NNK to cAMP signaling pathway
N01688  ADRB3-UCP1 signaling pathway
N01794  HCRT-HCRTR signaling pathway
Disease
H00244  Pseudohypoparathyroidism
H00441  Progressive osseous heteroplasia
H00501  Fibrous dysplasia, polyostotic
H01102  Pituitary adenomas
H01431  Cushing syndrome
H01483  Acromegaly
H02049  Bilateral macronodular adrenal hyperplasia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    2778 (GNAS)
   04020 Calcium signaling pathway
    2778 (GNAS)
   04072 Phospholipase D signaling pathway
    2778 (GNAS)
   04024 cAMP signaling pathway
    2778 (GNAS)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    2778 (GNAS)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    2778 (GNAS)
  09152 Endocrine system
   04911 Insulin secretion
    2778 (GNAS)
   04922 Glucagon signaling pathway
    2778 (GNAS)
   04923 Regulation of lipolysis in adipocytes
    2778 (GNAS)
   04912 GnRH signaling pathway
    2778 (GNAS)
   04913 Ovarian steroidogenesis
    2778 (GNAS)
   04915 Estrogen signaling pathway
    2778 (GNAS)
   04921 Oxytocin signaling pathway
    2778 (GNAS)
   04926 Relaxin signaling pathway
    2778 (GNAS)
   04935 Growth hormone synthesis, secretion and action
    2778 (GNAS)
   04918 Thyroid hormone synthesis
    2778 (GNAS)
   04928 Parathyroid hormone synthesis, secretion and action
    2778 (GNAS)
   04916 Melanogenesis
    2778 (GNAS)
   04924 Renin secretion
    2778 (GNAS)
   04925 Aldosterone synthesis and secretion
    2778 (GNAS)
   04927 Cortisol synthesis and secretion
    2778 (GNAS)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    2778 (GNAS)
   04270 Vascular smooth muscle contraction
    2778 (GNAS)
  09154 Digestive system
   04970 Salivary secretion
    2778 (GNAS)
   04971 Gastric acid secretion
    2778 (GNAS)
   04972 Pancreatic secretion
    2778 (GNAS)
   04976 Bile secretion
    2778 (GNAS)
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    2778 (GNAS)
   04961 Endocrine and other factor-regulated calcium reabsorption
    2778 (GNAS)
  09156 Nervous system
   04724 Glutamatergic synapse
    2778 (GNAS)
   04728 Dopaminergic synapse
    2778 (GNAS)
   04726 Serotonergic synapse
    2778 (GNAS)
   04730 Long-term depression
    2778 (GNAS)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    2778 (GNAS)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2778 (GNAS)
   04714 Thermogenesis
    2778 (GNAS)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2778 (GNAS)
   05207 Chemical carcinogenesis - receptor activation
    2778 (GNAS)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    2778 (GNAS)
   05165 Human papillomavirus infection
    2778 (GNAS)
  09171 Infectious disease: bacterial
   05110 Vibrio cholerae infection
    2778 (GNAS)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    2778 (GNAS)
   05142 Chagas disease
    2778 (GNAS)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    2778 (GNAS)
  09165 Substance dependence
   05030 Cocaine addiction
    2778 (GNAS)
   05031 Amphetamine addiction
    2778 (GNAS)
   05032 Morphine addiction
    2778 (GNAS)
   05034 Alcoholism
    2778 (GNAS)
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    2778 (GNAS)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    2778 (GNAS)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    2778 (GNAS)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    2778 (GNAS)
   04031 GTP-binding proteins [BR:hsa04031]
    2778 (GNAS)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   2778 (GNAS)
  Exosomal proteins of other body fluids (saliva and urine)
   2778 (GNAS)
  Exosomal proteins of colorectal cancer cells
   2778 (GNAS)
  Exosomal proteins of bladder cancer cells
   2778 (GNAS)
GTP-binding proteins [BR:hsa04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 2 (Gs)
    2778 (GNAS)
SSDB
Motif
Pfam: G-alpha Arf Gtr1_RagA Roc GTP_EFTU AAA_29 TniB FtsK_SpoIIIE
Other DBs
NCBI-GeneID: 2778
NCBI-ProteinID: NP_000507
OMIM: 139320
HGNC: 4392
Ensembl: ENSG00000087460
UniProt: P63092 O95467 A0A0S2Z3H8
Structure
LinkDB
Position
20:58839748..58911192
AA seq 394 aa
MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKSTIVKQM
RILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELA
NPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLD
KIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFND
VTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEK
VLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCY
PHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL
NT seq 1185 nt   +upstreamnt  +downstreamnt
atgggctgcctcgggaacagtaagaccgaggaccagcgcaacgaggagaaggcgcagcgt
gaggccaacaaaaagatcgagaagcagctgcagaaggacaagcaggtctaccgggccacg
caccgcctgctgctgctgggtgctggagaatctggtaaaagcaccattgtgaagcagatg
aggatcctgcatgttaatgggtttaatggagagggcggcgaagaggacccgcaggctgca
aggagcaacagcgatggtgagaaggcaaccaaagtgcaggacatcaaaaacaacctgaaa
gaggcgattgaaaccattgtggccgccatgagcaacctggtgccccccgtggagctggcc
aaccccgagaaccagttcagagtggactacatcctgagtgtgatgaacgtgcctgacttt
gacttccctcccgaattctatgagcatgccaaggctctgtgggaggatgaaggagtgcgt
gcctgctacgaacgctccaacgagtaccagctgattgactgtgcccagtacttcctggac
aagatcgacgtgatcaagcaggctgactatgtgccgagcgatcaggacctgcttcgctgc
cgtgtcctgacttctggaatctttgagaccaagttccaggtggacaaagtcaacttccac
atgtttgacgtgggtggccagcgcgatgaacgccgcaagtggatccagtgcttcaacgat
gtgactgccatcatcttcgtggtggccagcagcagctacaacatggtcatccgggaggac
aaccagaccaaccgcctgcaggaggctctgaacctcttcaagagcatctggaacaacaga
tggctgcgcaccatctctgtgatcctgttcctcaacaagcaagatctgctcgctgagaaa
gtccttgctgggaaatcgaagattgaggactactttccagaatttgctcgctacactact
cctgaggatgctactcccgagcccggagaggacccacgcgtgacccgggccaagtacttc
attcgagatgagtttctgaggatcagcactgccagtggagatgggcgtcactactgctac
cctcatttcacctgcgctgtggacactgagaacatccgccgtgtgttcaacgactgccgt
gacatcattcagcgcatgcaccttcgtcagtacgagctgctctaa

KEGG   Homo sapiens (human): 2782
Entry
2782              CDS       T01001                                 
Symbol
GNB1, HG2A, MDS, MRD42
Name
(RefSeq) G protein subunit beta 1
  KO
K04536  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04014  Ras signaling pathway
hsa04062  Chemokine signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04371  Apelin signaling pathway
hsa04713  Circadian entrainment
hsa04723  Retrograde endocannabinoid signaling
hsa04724  Glutamatergic synapse
hsa04725  Cholinergic synapse
hsa04726  Serotonergic synapse
hsa04727  GABAergic synapse
hsa04728  Dopaminergic synapse
hsa04740  Olfactory transduction
hsa04744  Phototransduction
hsa04926  Relaxin signaling pathway
hsa05032  Morphine addiction
hsa05034  Alcoholism
hsa05163  Human cytomegalovirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06167  Human cytomegalovirus (HCMV)
nt06224  CXCR signaling (cancer)
nt06530  PI3K signaling
nt06533  Chemokine signaling
  Element
N00152  CXCR-GNB/G-ERK signaling pathway
N00153  CCR/CXCR-GNB/G-PI3K-RAC signaling pathway
N00154  CXCR-GNB/G-PI3K-AKT signaling pathway
N00157  KSHV vGPCR to GNB/G-ERK signaling pathway
N00158  KSHV vGPCR to GNB/G-PI3K-AKT signaling pathway
N00178  KSHV vGPCR to GNB/G-PI3K-JNK signaling pathway
N00399  CCR2-GNB/G-PI3K-NFKB signaling pathway
N00400  HCMV US28 to GNB/G-PI3K-NFKB signaling pathway
N00408  LPAR-GNB/G-Rho signaling pathway
N00409  HCMV UL33 to GNB/G-Rho signaling pathway
N00413  CXCR4-GNB/G-PLCB-PKC signaling pathway
N00428  CCR5-GNB/G-PLCB/G-PKC signaling pathway
N00433  CXCR4-GNB/G-RAC signaling pathway
N00434  HIV gp120 to CXCR4-GNB/G-RAC signaling pathway
N01657  GPCR-PI3K signaling pathway
N01746  CCR/CXCR-GNB/G-PI3K signaling pathway
N01769  CCR5-GNB/G-PLCB/G signaling pathway
N01770  CCR2-GNB/G-PI3K signaling pathway
N01771  CXCR4-GNB/G signaling pathway
Disease
H00773  Autosomal dominant intellectual developmental disorder
H01481  Myelodysplastic syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    2782 (GNB1)
   04371 Apelin signaling pathway
    2782 (GNB1)
   04151 PI3K-Akt signaling pathway
    2782 (GNB1)
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    2782 (GNB1)
  09152 Endocrine system
   04926 Relaxin signaling pathway
    2782 (GNB1)
  09156 Nervous system
   04724 Glutamatergic synapse
    2782 (GNB1)
   04727 GABAergic synapse
    2782 (GNB1)
   04725 Cholinergic synapse
    2782 (GNB1)
   04728 Dopaminergic synapse
    2782 (GNB1)
   04726 Serotonergic synapse
    2782 (GNB1)
   04723 Retrograde endocannabinoid signaling
    2782 (GNB1)
  09157 Sensory system
   04744 Phototransduction
    2782 (GNB1)
   04740 Olfactory transduction
    2782 (GNB1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2782 (GNB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2782 (GNB1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    2782 (GNB1)
   05163 Human cytomegalovirus infection
    2782 (GNB1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    2782 (GNB1)
  09165 Substance dependence
   05032 Morphine addiction
    2782 (GNB1)
   05034 Alcoholism
    2782 (GNB1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    2782 (GNB1)
   04031 GTP-binding proteins [BR:hsa04031]
    2782 (GNB1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   2782 (GNB1)
  Exosomal proteins of colorectal cancer cells
   2782 (GNB1)
  Exosomal proteins of melanoma cells
   2782 (GNB1)
GTP-binding proteins [BR:hsa04031]
 Heterotrimeric G-proteins
  Beta Subunits
   Beta [OT]
    2782 (GNB1)
SSDB
Motif
Pfam: WD40 ANAPC4_WD40 NBCH_WD40 WD40_like eIF2A Myc-LZ Cytochrom_D1 DUF4407 CaM_bind
Other DBs
NCBI-GeneID: 2782
NCBI-ProteinID: NP_001269468
OMIM: 139380
HGNC: 4396
Ensembl: ENSG00000078369
UniProt: P62873 A0A140VJJ8
Structure
LinkDB
Position
1:complement(1785286..1891087)
AA seq 340 aa
MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYA
MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNI
CSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTF
TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA
FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL
KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
NT seq 1023 nt   +upstreamnt  +downstreamnt
atgagtgagcttgaccagttacggcaggaggccgagcaacttaagaaccagattcgagac
gccaggaaagcatgtgcagatgcaactctctctcagatcacaaacaacatcgacccagtg
ggaagaatccaaatgcgcacgaggaggacactgcgggggcacctggccaagatctacgcc
atgcactggggcacagactccaggcttctcgtcagtgcctcgcaggatggtaaacttatc
atctgggacagctacaccaccaacaaggtccacgccatccctctgcgctcctcctgggtc
atgacctgtgcatatgccccttctgggaactatgtggcctgcggtggcctggataacatt
tgctccatttacaatctgaaaactcgtgaggggaacgtgcgcgtgagtcgtgagctggca
ggacacacaggttacctgtcctgctgccgattcctggatgacaatcagatcgtcaccagc
tctggagacaccacgtgtgccctgtgggacatcgagaccggccagcagacgaccacgttt
accggacacactggagatgtcatgagcctttctcttgctcctgacaccagactgttcgtc
tctggtgcttgtgatgcttcagccaaactctgggatgtgcgagaaggcatgtgccggcag
accttcactggccacgagtctgacatcaatgccatttgcttctttccaaatggcaatgca
tttgccactggctcagacgacgccacctgcaggctgtttgaccttcgtgctgaccaggag
ctcatgacttactcccatgacaacatcatctgcgggatcacctctgtctccttctccaag
agcgggcgcctcctccttgctgggtacgacgacttcaactgcaacgtctgggatgcactc
aaagccgaccgggcaggtgtcttggctgggcatgacaaccgcgtcagctgcctgggcgtg
actgacgatggcatggctgtggcgacagggtcctgggatagcttcctcaagatctggaac
taa

KEGG   Homo sapiens (human): 2783
Entry
2783              CDS       T01001                                 
Symbol
GNB2, HG2C1, SSS4, NEDHYDF
Name
(RefSeq) G protein subunit beta 2
  KO
K04537  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04014  Ras signaling pathway
hsa04062  Chemokine signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04371  Apelin signaling pathway
hsa04713  Circadian entrainment
hsa04723  Retrograde endocannabinoid signaling
hsa04724  Glutamatergic synapse
hsa04725  Cholinergic synapse
hsa04726  Serotonergic synapse
hsa04727  GABAergic synapse
hsa04728  Dopaminergic synapse
hsa04926  Relaxin signaling pathway
hsa05032  Morphine addiction
hsa05034  Alcoholism
hsa05163  Human cytomegalovirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06167  Human cytomegalovirus (HCMV)
nt06224  CXCR signaling (cancer)
nt06530  PI3K signaling
nt06533  Chemokine signaling
  Element
N00152  CXCR-GNB/G-ERK signaling pathway
N00153  CCR/CXCR-GNB/G-PI3K-RAC signaling pathway
N00154  CXCR-GNB/G-PI3K-AKT signaling pathway
N00157  KSHV vGPCR to GNB/G-ERK signaling pathway
N00158  KSHV vGPCR to GNB/G-PI3K-AKT signaling pathway
N00178  KSHV vGPCR to GNB/G-PI3K-JNK signaling pathway
N00399  CCR2-GNB/G-PI3K-NFKB signaling pathway
N00400  HCMV US28 to GNB/G-PI3K-NFKB signaling pathway
N00408  LPAR-GNB/G-Rho signaling pathway
N00409  HCMV UL33 to GNB/G-Rho signaling pathway
N00413  CXCR4-GNB/G-PLCB-PKC signaling pathway
N00428  CCR5-GNB/G-PLCB/G-PKC signaling pathway
N00433  CXCR4-GNB/G-RAC signaling pathway
N00434  HIV gp120 to CXCR4-GNB/G-RAC signaling pathway
N01657  GPCR-PI3K signaling pathway
N01746  CCR/CXCR-GNB/G-PI3K signaling pathway
N01769  CCR5-GNB/G-PLCB/G signaling pathway
N01770  CCR2-GNB/G-PI3K signaling pathway
N01771  CXCR4-GNB/G signaling pathway
Disease
H00729  Sick sinus syndrome
H02705  Neurodevelopmental disorder with glutamatergic synapse dysfunction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    2783 (GNB2)
   04371 Apelin signaling pathway
    2783 (GNB2)
   04151 PI3K-Akt signaling pathway
    2783 (GNB2)
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    2783 (GNB2)
  09152 Endocrine system
   04926 Relaxin signaling pathway
    2783 (GNB2)
  09156 Nervous system
   04724 Glutamatergic synapse
    2783 (GNB2)
   04727 GABAergic synapse
    2783 (GNB2)
   04725 Cholinergic synapse
    2783 (GNB2)
   04728 Dopaminergic synapse
    2783 (GNB2)
   04726 Serotonergic synapse
    2783 (GNB2)
   04723 Retrograde endocannabinoid signaling
    2783 (GNB2)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2783 (GNB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2783 (GNB2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    2783 (GNB2)
   05163 Human cytomegalovirus infection
    2783 (GNB2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    2783 (GNB2)
  09165 Substance dependence
   05032 Morphine addiction
    2783 (GNB2)
   05034 Alcoholism
    2783 (GNB2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    2783 (GNB2)
   04031 GTP-binding proteins [BR:hsa04031]
    2783 (GNB2)
Exosome [BR:hsa04147]
 Exosomal proteins
  Proteins found in most exosomes
   2783 (GNB2)
GTP-binding proteins [BR:hsa04031]
 Heterotrimeric G-proteins
  Beta Subunits
   Beta [OT]
    2783 (GNB2)
SSDB
Motif
Pfam: WD40 ANAPC4_WD40 NBCH_WD40 WD40_like Acanthaporin
Other DBs
NCBI-GeneID: 2783
NCBI-ProteinID: NP_005264
OMIM: 139390
HGNC: 4398
Ensembl: ENSG00000172354
UniProt: P62879 Q6FHM2
LinkDB
Position
7:100673740..100679169
AA seq 340 aa
MSELEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYA
MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNI
CSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGF
AGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYA
FTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAM
KGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
NT seq 1023 nt   +upstreamnt  +downstreamnt
atgagtgagctggagcaactgagacaggaggccgagcagctccggaaccagatccgggat
gcccgaaaagcatgtggggactcaacactgacccagatcacagctgggctggacccagtg
gggagaatccagatgaggacccggaggaccctccgtgggcacctggcaaagatctatgcc
atgcactgggggaccgactcaaggctgctggtcagcgcctcccaggatgggaagctcatc
atctgggacagctacaccaccaacaaggtccacgccatcccgctgcgctcctcctgggta
atgacctgtgcctacgcgccctcagggaactttgtggcctgtggggggttggacaacatc
tgctccatctacagcctcaagacccgcgagggcaacgtcagggtcagccgggagctgcct
ggccacactgggtacctgtcgtgttgccgcttcctggatgacaaccaaatcatcaccagc
tctggggataccacctgtgccctgtgggacattgagacaggccagcagacagtgggtttt
gctggacacagtggggatgtgatgtccctgtccctggcccccgatggccgcacgtttgtg
tcaggcgcctgtgatgcctctatcaagctgtgggacgtgcgggattccatgtgccgacag
accttcatcggccatgaatccgacatcaatgcagtggctttcttccccaacggctacgcc
ttcaccaccggctctgacgacgccacgtgccgcctcttcgacctgcgggccgatcaggag
ctcctcatgtactcccatgacaacatcatctgtggcatcacctctgttgccttctcgcgc
agcggacggctgctgctcgctggctacgacgacttcaactgcaacatctgggatgccatg
aagggcgaccgtgcaggagtcctcgctggccacgacaaccgcgtgagctgcctcggggtc
accgacgatggcatggctgtggccacgggctcctgggactccttcctcaagatctggaac
taa

KEGG   Homo sapiens (human): 2784
Entry
2784              CDS       T01001                                 
Symbol
GNB3, CSNB1H, HG2D
Name
(RefSeq) G protein subunit beta 3
  KO
K07825  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04014  Ras signaling pathway
hsa04062  Chemokine signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04371  Apelin signaling pathway
hsa04713  Circadian entrainment
hsa04723  Retrograde endocannabinoid signaling
hsa04724  Glutamatergic synapse
hsa04725  Cholinergic synapse
hsa04726  Serotonergic synapse
hsa04727  GABAergic synapse
hsa04728  Dopaminergic synapse
hsa04742  Taste transduction
hsa04926  Relaxin signaling pathway
hsa05032  Morphine addiction
hsa05034  Alcoholism
hsa05163  Human cytomegalovirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06167  Human cytomegalovirus (HCMV)
nt06224  CXCR signaling (cancer)
nt06530  PI3K signaling
nt06533  Chemokine signaling
  Element
N00152  CXCR-GNB/G-ERK signaling pathway
N00153  CCR/CXCR-GNB/G-PI3K-RAC signaling pathway
N00154  CXCR-GNB/G-PI3K-AKT signaling pathway
N00157  KSHV vGPCR to GNB/G-ERK signaling pathway
N00158  KSHV vGPCR to GNB/G-PI3K-AKT signaling pathway
N00178  KSHV vGPCR to GNB/G-PI3K-JNK signaling pathway
N00399  CCR2-GNB/G-PI3K-NFKB signaling pathway
N00400  HCMV US28 to GNB/G-PI3K-NFKB signaling pathway
N00408  LPAR-GNB/G-Rho signaling pathway
N00409  HCMV UL33 to GNB/G-Rho signaling pathway
N00413  CXCR4-GNB/G-PLCB-PKC signaling pathway
N00428  CCR5-GNB/G-PLCB/G-PKC signaling pathway
N00433  CXCR4-GNB/G-RAC signaling pathway
N00434  HIV gp120 to CXCR4-GNB/G-RAC signaling pathway
N01657  GPCR-PI3K signaling pathway
N01746  CCR/CXCR-GNB/G-PI3K signaling pathway
N01769  CCR5-GNB/G-PLCB/G signaling pathway
N01770  CCR2-GNB/G-PI3K signaling pathway
N01771  CXCR4-GNB/G signaling pathway
Disease
H00787  Congenital stationary night blindness
H01633  High blood pressure
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    2784 (GNB3)
   04371 Apelin signaling pathway
    2784 (GNB3)
   04151 PI3K-Akt signaling pathway
    2784 (GNB3)
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    2784 (GNB3)
  09152 Endocrine system
   04926 Relaxin signaling pathway
    2784 (GNB3)
  09156 Nervous system
   04724 Glutamatergic synapse
    2784 (GNB3)
   04727 GABAergic synapse
    2784 (GNB3)
   04725 Cholinergic synapse
    2784 (GNB3)
   04728 Dopaminergic synapse
    2784 (GNB3)
   04726 Serotonergic synapse
    2784 (GNB3)
   04723 Retrograde endocannabinoid signaling
    2784 (GNB3)
  09157 Sensory system
   04742 Taste transduction
    2784 (GNB3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2784 (GNB3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2784 (GNB3)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    2784 (GNB3)
   05163 Human cytomegalovirus infection
    2784 (GNB3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    2784 (GNB3)
  09165 Substance dependence
   05032 Morphine addiction
    2784 (GNB3)
   05034 Alcoholism
    2784 (GNB3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    2784 (GNB3)
   04031 GTP-binding proteins [BR:hsa04031]
    2784 (GNB3)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   2784 (GNB3)
GTP-binding proteins [BR:hsa04031]
 Heterotrimeric G-proteins
  Beta Subunits
   Beta [OT]
    2784 (GNB3)
SSDB
Motif
Pfam: WD40 ANAPC4_WD40 NBCH_WD40 eIF2A WD40_like Cytochrom_D1 Acanthaporin
Other DBs
NCBI-GeneID: 2784
NCBI-ProteinID: NP_002066
OMIM: 139130
HGNC: 4400
Ensembl: ENSG00000111664
UniProt: P16520 F1T0G5
LinkDB
Position
12:6840925..6847393
AA seq 340 aa
MGEMEQLRQEAEQLKKQIADARKACADVTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYA
MHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNM
CSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVF
VGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEA
ICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSM
KSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN
NT seq 1023 nt   +upstreamnt  +downstreamnt
atgggggagatggagcaactgcgtcaggaagcggagcagctcaagaagcagattgcagat
gccaggaaagcctgtgctgacgttactctggcagagctggtgtctggcctagaggtggtg
ggacgagtccagatgcggacgcggcggacgttaaggggacacctggccaagatttacgcc
atgcactgggccactgattctaagctgctggtaagtgcctcgcaagatgggaagctgatc
gtgtgggacagctacaccaccaacaaggtgcacgccatcccactgcgctcctcctgggtc
atgacctgtgcctatgccccatcagggaactttgtggcatgtggggggctggacaacatg
tgttccatctacaacctcaaatcccgtgagggcaatgtcaaggtcagccgggagctttct
gctcacacaggttatctctcctgctgccgcttcctggatgacaacaatattgtgaccagc
tcgggggacaccacgtgtgccttgtgggacattgagactgggcagcagaagactgtattt
gtgggacacacgggtgactgcatgagcctggctgtgtctcctgacttcaatctcttcatt
tcgggggcctgtgatgccagtgccaagctctgggatgtgcgagaggggacctgccgtcag
actttcactggccacgagtcggacatcaacgccatctgtttcttccccaatggagaggcc
atctgcacgggctcggatgacgcttcctgccgcttgtttgacctgcgggcagaccaggag
ctgatctgcttctcccacgagagcatcatctgcggcatcacgtccgtggccttctccctc
agtggccgcctactattcgctggctacgacgacttcaactgcaatgtctgggactccatg
aagtctgagcgtgtgggcatcctctctggccacgataacagggtgagctgcctgggagtc
acagctgacgggatggctgtggccacaggttcctgggacagcttcctcaaaatctggaac
tga

KEGG   Homo sapiens (human): 2785
Entry
2785              CDS       T01001                                 
Symbol
GNG3, HG3D
Name
(RefSeq) G protein subunit gamma 3
  KO
K04540  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04014  Ras signaling pathway
hsa04062  Chemokine signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04371  Apelin signaling pathway
hsa04713  Circadian entrainment
hsa04723  Retrograde endocannabinoid signaling
hsa04724  Glutamatergic synapse
hsa04725  Cholinergic synapse
hsa04726  Serotonergic synapse
hsa04727  GABAergic synapse
hsa04728  Dopaminergic synapse
hsa04926  Relaxin signaling pathway
hsa05032  Morphine addiction
hsa05034  Alcoholism
hsa05163  Human cytomegalovirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06167  Human cytomegalovirus (HCMV)
nt06224  CXCR signaling (cancer)
nt06530  PI3K signaling
nt06533  Chemokine signaling
  Element
N00152  CXCR-GNB/G-ERK signaling pathway
N00153  CCR/CXCR-GNB/G-PI3K-RAC signaling pathway
N00154  CXCR-GNB/G-PI3K-AKT signaling pathway
N00157  KSHV vGPCR to GNB/G-ERK signaling pathway
N00158  KSHV vGPCR to GNB/G-PI3K-AKT signaling pathway
N00178  KSHV vGPCR to GNB/G-PI3K-JNK signaling pathway
N00399  CCR2-GNB/G-PI3K-NFKB signaling pathway
N00400  HCMV US28 to GNB/G-PI3K-NFKB signaling pathway
N00408  LPAR-GNB/G-Rho signaling pathway
N00409  HCMV UL33 to GNB/G-Rho signaling pathway
N00413  CXCR4-GNB/G-PLCB-PKC signaling pathway
N00428  CCR5-GNB/G-PLCB/G-PKC signaling pathway
N00433  CXCR4-GNB/G-RAC signaling pathway
N00434  HIV gp120 to CXCR4-GNB/G-RAC signaling pathway
N01657  GPCR-PI3K signaling pathway
N01746  CCR/CXCR-GNB/G-PI3K signaling pathway
N01769  CCR5-GNB/G-PLCB/G signaling pathway
N01770  CCR2-GNB/G-PI3K signaling pathway
N01771  CXCR4-GNB/G signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    2785 (GNG3)
   04371 Apelin signaling pathway
    2785 (GNG3)
   04151 PI3K-Akt signaling pathway
    2785 (GNG3)
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    2785 (GNG3)
  09152 Endocrine system
   04926 Relaxin signaling pathway
    2785 (GNG3)
  09156 Nervous system
   04724 Glutamatergic synapse
    2785 (GNG3)
   04727 GABAergic synapse
    2785 (GNG3)
   04725 Cholinergic synapse
    2785 (GNG3)
   04728 Dopaminergic synapse
    2785 (GNG3)
   04726 Serotonergic synapse
    2785 (GNG3)
   04723 Retrograde endocannabinoid signaling
    2785 (GNG3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2785 (GNG3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2785 (GNG3)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    2785 (GNG3)
   05163 Human cytomegalovirus infection
    2785 (GNG3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    2785 (GNG3)
  09165 Substance dependence
   05032 Morphine addiction
    2785 (GNG3)
   05034 Alcoholism
    2785 (GNG3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04031 GTP-binding proteins [BR:hsa04031]
    2785 (GNG3)
GTP-binding proteins [BR:hsa04031]
 Heterotrimeric G-proteins
  Gamma Subunits
   Gamma [OT]
    2785 (GNG3)
SSDB
Motif
Pfam: G-gamma GPR158_179_EC
Other DBs
NCBI-GeneID: 2785
NCBI-ProteinID: NP_036334
OMIM: 608941
HGNC: 4405
Ensembl: ENSG00000162188
UniProt: P63215
LinkDB
Position
11:62706446..62709201
AA seq 75 aa
MKGETPVNSTMSIGQARKMVEQLKIEASLCRIKVSKAAADLMTYCDAHACEDPLITPVPT
SENPFREKKFFCALL
NT seq 228 nt   +upstreamnt  +downstreamnt
atgaaaggtgagaccccggtgaacagcactatgagtattgggcaagcacgcaagatggtg
gaacagcttaagattgaagccagcttgtgtcggataaaggtgtccaaggcagcagcagac
ctgatgacttactgtgatgcccacgcctgtgaggatcccctcatcacccctgtgcccact
tcggagaaccccttccgggagaagaagttcttctgtgctctcctctga

KEGG   Homo sapiens (human): 2786
Entry
2786              CDS       T01001                                 
Symbol
GNG4, HG3C
Name
(RefSeq) G protein subunit gamma 4
  KO
K04541  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
Organism
hsa  Homo sapiens (human)
Pathway
hsa04014  Ras signaling pathway
hsa04062  Chemokine signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04371  Apelin signaling pathway
hsa04713  Circadian entrainment
hsa04723  Retrograde endocannabinoid signaling
hsa04724  Glutamatergic synapse
hsa04725  Cholinergic synapse
hsa04726  Serotonergic synapse
hsa04727  GABAergic synapse
hsa04728  Dopaminergic synapse
hsa04926  Relaxin signaling pathway
hsa05032  Morphine addiction
hsa05034  Alcoholism
hsa05163  Human cytomegalovirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06167  Human cytomegalovirus (HCMV)
nt06224  CXCR signaling (cancer)
nt06530  PI3K signaling
nt06533  Chemokine signaling
  Element
N00152  CXCR-GNB/G-ERK signaling pathway
N00153  CCR/CXCR-GNB/G-PI3K-RAC signaling pathway
N00154  CXCR-GNB/G-PI3K-AKT signaling pathway
N00157  KSHV vGPCR to GNB/G-ERK signaling pathway
N00158  KSHV vGPCR to GNB/G-PI3K-AKT signaling pathway
N00178  KSHV vGPCR to GNB/G-PI3K-JNK signaling pathway
N00399  CCR2-GNB/G-PI3K-NFKB signaling pathway
N00400  HCMV US28 to GNB/G-PI3K-NFKB signaling pathway
N00408  LPAR-GNB/G-Rho signaling pathway
N00409  HCMV UL33 to GNB/G-Rho signaling pathway
N00413  CXCR4-GNB/G-PLCB-PKC signaling pathway
N00428  CCR5-GNB/G-PLCB/G-PKC signaling pathway
N00433  CXCR4-GNB/G-RAC signaling pathway
N00434  HIV gp120 to CXCR4-GNB/G-RAC signaling pathway
N01657  GPCR-PI3K signaling pathway
N01746  CCR/CXCR-GNB/G-PI3K signaling pathway
N01769  CCR5-GNB/G-PLCB/G signaling pathway
N01770  CCR2-GNB/G-PI3K signaling pathway
N01771  CXCR4-GNB/G signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    2786 (GNG4)
   04371 Apelin signaling pathway
    2786 (GNG4)
   04151 PI3K-Akt signaling pathway
    2786 (GNG4)
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    2786 (GNG4)
  09152 Endocrine system
   04926 Relaxin signaling pathway
    2786 (GNG4)
  09156 Nervous system
   04724 Glutamatergic synapse
    2786 (GNG4)
   04727 GABAergic synapse
    2786 (GNG4)
   04725 Cholinergic synapse
    2786 (GNG4)
   04728 Dopaminergic synapse
    2786 (GNG4)
   04726 Serotonergic synapse
    2786 (GNG4)
   04723 Retrograde endocannabinoid signaling
    2786 (GNG4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2786 (GNG4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2786 (GNG4)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    2786 (GNG4)
   05163 Human cytomegalovirus infection
    2786 (GNG4)
   05167 Kaposi sarcoma-associated herpesvirus infection
    2786 (GNG4)
  09165 Substance dependence
   05032 Morphine addiction
    2786 (GNG4)
   05034 Alcoholism
    2786 (GNG4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04031 GTP-binding proteins [BR:hsa04031]
    2786 (GNG4)
GTP-binding proteins [BR:hsa04031]
 Heterotrimeric G-proteins
  Gamma Subunits
   Gamma [OT]
    2786 (GNG4)
SSDB
Motif
Pfam: G-gamma ATP-synt_F Adeno_PV
Other DBs
NCBI-GeneID: 2786
NCBI-ProteinID: NP_001092191
OMIM: 604388
HGNC: 4407
Ensembl: ENSG00000168243
UniProt: P50150 B1APZ0
LinkDB
Position
1:complement(235547685..235650608)
AA seq 75 aa
MKEGMSNNSTTSISQARKAVEQLKMEACMDRVKVSQAAADLLAYCEAHVREDPLIIPVPA
SENPFREKKFFCTIL
NT seq 228 nt   +upstreamnt  +downstreamnt
atgaaagagggcatgtctaataacagcaccactagcatctcccaagccaggaaagctgtg
gagcagctaaagatggaagcctgtatggacagggtcaaggtctcccaggcagctgcggac
ctcctggcctactgtgaagctcacgtgcgggaagatcctctcatcattccagtgcctgca
tcagaaaacccctttcgcgagaagaagttcttttgtaccattctctaa

KEGG   Homo sapiens (human): 2787
Entry
2787              CDS       T01001                                 
Symbol
GNG5
Name
(RefSeq) G protein subunit gamma 5
  KO
K04542  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
Organism
hsa  Homo sapiens (human)
Pathway
hsa04014  Ras signaling pathway
hsa04062  Chemokine signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04371  Apelin signaling pathway
hsa04713  Circadian entrainment
hsa04723  Retrograde endocannabinoid signaling
hsa04724  Glutamatergic synapse
hsa04725  Cholinergic synapse
hsa04726  Serotonergic synapse
hsa04727  GABAergic synapse
hsa04728  Dopaminergic synapse
hsa04926  Relaxin signaling pathway
hsa05032  Morphine addiction
hsa05034  Alcoholism
hsa05163  Human cytomegalovirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06167  Human cytomegalovirus (HCMV)
nt06224  CXCR signaling (cancer)
nt06530  PI3K signaling
nt06533  Chemokine signaling
  Element
N00152  CXCR-GNB/G-ERK signaling pathway
N00153  CCR/CXCR-GNB/G-PI3K-RAC signaling pathway
N00154  CXCR-GNB/G-PI3K-AKT signaling pathway
N00157  KSHV vGPCR to GNB/G-ERK signaling pathway
N00158  KSHV vGPCR to GNB/G-PI3K-AKT signaling pathway
N00178  KSHV vGPCR to GNB/G-PI3K-JNK signaling pathway
N00399  CCR2-GNB/G-PI3K-NFKB signaling pathway
N00400  HCMV US28 to GNB/G-PI3K-NFKB signaling pathway
N00408  LPAR-GNB/G-Rho signaling pathway
N00409  HCMV UL33 to GNB/G-Rho signaling pathway
N00413  CXCR4-GNB/G-PLCB-PKC signaling pathway
N00428  CCR5-GNB/G-PLCB/G-PKC signaling pathway
N00433  CXCR4-GNB/G-RAC signaling pathway
N00434  HIV gp120 to CXCR4-GNB/G-RAC signaling pathway
N01657  GPCR-PI3K signaling pathway
N01746  CCR/CXCR-GNB/G-PI3K signaling pathway
N01769  CCR5-GNB/G-PLCB/G signaling pathway
N01770  CCR2-GNB/G-PI3K signaling pathway
N01771  CXCR4-GNB/G signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    2787 (GNG5)
   04371 Apelin signaling pathway
    2787 (GNG5)
   04151 PI3K-Akt signaling pathway
    2787 (GNG5)
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    2787 (GNG5)
  09152 Endocrine system
   04926 Relaxin signaling pathway
    2787 (GNG5)
  09156 Nervous system
   04724 Glutamatergic synapse
    2787 (GNG5)
   04727 GABAergic synapse
    2787 (GNG5)
   04725 Cholinergic synapse
    2787 (GNG5)
   04728 Dopaminergic synapse
    2787 (GNG5)
   04726 Serotonergic synapse
    2787 (GNG5)
   04723 Retrograde endocannabinoid signaling
    2787 (GNG5)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2787 (GNG5)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2787 (GNG5)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    2787 (GNG5)
   05163 Human cytomegalovirus infection
    2787 (GNG5)
   05167 Kaposi sarcoma-associated herpesvirus infection
    2787 (GNG5)
  09165 Substance dependence
   05032 Morphine addiction
    2787 (GNG5)
   05034 Alcoholism
    2787 (GNG5)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    2787 (GNG5)
   04031 GTP-binding proteins [BR:hsa04031]
    2787 (GNG5)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   2787 (GNG5)
GTP-binding proteins [BR:hsa04031]
 Heterotrimeric G-proteins
  Gamma Subunits
   Gamma [OT]
    2787 (GNG5)
SSDB
Motif
Pfam: G-gamma Suv3_N FtsX_ECD
Other DBs
NCBI-GeneID: 2787
NCBI-ProteinID: NP_005265
OMIM: 600874
HGNC: 4408
Ensembl: ENSG00000174021
UniProt: P63218
LinkDB
Position
1:complement(84498325..84506581)
AA seq 68 aa
MSGSSSVAAMKKVVQQLRLEAGLNRVKVSQAAADLKQFCLQNAQHDPLLTGVSSSTNPFR
PQKVCSFL
NT seq 207 nt   +upstreamnt  +downstreamnt
atgtctggctcctccagcgtcgccgctatgaagaaagtggttcaacagctccggctggag
gccggactcaaccgcgtaaaagtttcccaggcagctgcagacttgaaacagttctgtctg
cagaatgctcaacatgaccctctgctgactggagtatcttcaagtacaaatcccttcaga
ccccagaaagtctgttcctttttgtag

KEGG   Homo sapiens (human): 2788
Entry
2788              CDS       T01001                                 
Symbol
GNG7, HG3B
Name
(RefSeq) G protein subunit gamma 7
  KO
K04543  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
Organism
hsa  Homo sapiens (human)
Pathway
hsa04014  Ras signaling pathway
hsa04062  Chemokine signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04371  Apelin signaling pathway
hsa04713  Circadian entrainment
hsa04723  Retrograde endocannabinoid signaling
hsa04724  Glutamatergic synapse
hsa04725  Cholinergic synapse
hsa04726  Serotonergic synapse
hsa04727  GABAergic synapse
hsa04728  Dopaminergic synapse
hsa04740  Olfactory transduction
hsa04926  Relaxin signaling pathway
hsa05032  Morphine addiction
hsa05034  Alcoholism
hsa05163  Human cytomegalovirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06167  Human cytomegalovirus (HCMV)
nt06224  CXCR signaling (cancer)
nt06530  PI3K signaling
nt06533  Chemokine signaling
  Element
N00152  CXCR-GNB/G-ERK signaling pathway
N00153  CCR/CXCR-GNB/G-PI3K-RAC signaling pathway
N00154  CXCR-GNB/G-PI3K-AKT signaling pathway
N00157  KSHV vGPCR to GNB/G-ERK signaling pathway
N00158  KSHV vGPCR to GNB/G-PI3K-AKT signaling pathway
N00178  KSHV vGPCR to GNB/G-PI3K-JNK signaling pathway
N00399  CCR2-GNB/G-PI3K-NFKB signaling pathway
N00400  HCMV US28 to GNB/G-PI3K-NFKB signaling pathway
N00408  LPAR-GNB/G-Rho signaling pathway
N00409  HCMV UL33 to GNB/G-Rho signaling pathway
N00413  CXCR4-GNB/G-PLCB-PKC signaling pathway
N00428  CCR5-GNB/G-PLCB/G-PKC signaling pathway
N00433  CXCR4-GNB/G-RAC signaling pathway
N00434  HIV gp120 to CXCR4-GNB/G-RAC signaling pathway
N01657  GPCR-PI3K signaling pathway
N01746  CCR/CXCR-GNB/G-PI3K signaling pathway
N01769  CCR5-GNB/G-PLCB/G signaling pathway
N01770  CCR2-GNB/G-PI3K signaling pathway
N01771  CXCR4-GNB/G signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    2788 (GNG7)
   04371 Apelin signaling pathway
    2788 (GNG7)
   04151 PI3K-Akt signaling pathway
    2788 (GNG7)
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    2788 (GNG7)
  09152 Endocrine system
   04926 Relaxin signaling pathway
    2788 (GNG7)
  09156 Nervous system
   04724 Glutamatergic synapse
    2788 (GNG7)
   04727 GABAergic synapse
    2788 (GNG7)
   04725 Cholinergic synapse
    2788 (GNG7)
   04728 Dopaminergic synapse
    2788 (GNG7)
   04726 Serotonergic synapse
    2788 (GNG7)
   04723 Retrograde endocannabinoid signaling
    2788 (GNG7)
  09157 Sensory system
   04740 Olfactory transduction
    2788 (GNG7)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2788 (GNG7)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2788 (GNG7)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    2788 (GNG7)
   05163 Human cytomegalovirus infection
    2788 (GNG7)
   05167 Kaposi sarcoma-associated herpesvirus infection
    2788 (GNG7)
  09165 Substance dependence
   05032 Morphine addiction
    2788 (GNG7)
   05034 Alcoholism
    2788 (GNG7)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    2788 (GNG7)
   04031 GTP-binding proteins [BR:hsa04031]
    2788 (GNG7)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   2788 (GNG7)
  Exosomal proteins of other body fluids (saliva and urine)
   2788 (GNG7)
GTP-binding proteins [BR:hsa04031]
 Heterotrimeric G-proteins
  Gamma Subunits
   Gamma [OT]
    2788 (GNG7)
SSDB
Motif
Pfam: G-gamma FtsX_ECD
Other DBs
NCBI-GeneID: 2788
NCBI-ProteinID: NP_443079
OMIM: 604430
HGNC: 4410
Ensembl: ENSG00000176533
UniProt: O60262
LinkDB
Position
19:complement(2511219..2702694)
AA seq 68 aa
MSATNNIAQARKLVEQLRIEAGIERIKVSKAASDLMSYCEQHARNDPLLVGVPASENPFK
DKKPCIIL
NT seq 207 nt   +upstreamnt  +downstreamnt
atgtcagccactaacaacatagcccaggcccggaagctggtggaacagctacgcatagaa
gccgggattgagcgcatcaaggtctccaaagcggcgtctgacctcatgagctactgtgag
caacatgcccggaacgaccccctgctggtcggagtccctgcctcggagaacccctttaag
gacaagaaaccttgtattattttataa

KEGG   Homo sapiens (human): 2790
Entry
2790              CDS       T01001                                 
Symbol
GNG10
Name
(RefSeq) G protein subunit gamma 10
  KO
K04545  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
Organism
hsa  Homo sapiens (human)
Pathway
hsa04014  Ras signaling pathway
hsa04062  Chemokine signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04371  Apelin signaling pathway
hsa04713  Circadian entrainment
hsa04723  Retrograde endocannabinoid signaling
hsa04724  Glutamatergic synapse
hsa04725  Cholinergic synapse
hsa04726  Serotonergic synapse
hsa04727  GABAergic synapse
hsa04728  Dopaminergic synapse
hsa04926  Relaxin signaling pathway
hsa05032  Morphine addiction
hsa05034  Alcoholism
hsa05163  Human cytomegalovirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06167  Human cytomegalovirus (HCMV)
nt06224  CXCR signaling (cancer)
nt06530  PI3K signaling
nt06533  Chemokine signaling
  Element
N00152  CXCR-GNB/G-ERK signaling pathway
N00153  CCR/CXCR-GNB/G-PI3K-RAC signaling pathway
N00154  CXCR-GNB/G-PI3K-AKT signaling pathway
N00157  KSHV vGPCR to GNB/G-ERK signaling pathway
N00158  KSHV vGPCR to GNB/G-PI3K-AKT signaling pathway
N00178  KSHV vGPCR to GNB/G-PI3K-JNK signaling pathway
N00399  CCR2-GNB/G-PI3K-NFKB signaling pathway
N00400  HCMV US28 to GNB/G-PI3K-NFKB signaling pathway
N00408  LPAR-GNB/G-Rho signaling pathway
N00409  HCMV UL33 to GNB/G-Rho signaling pathway
N00413  CXCR4-GNB/G-PLCB-PKC signaling pathway
N00428  CCR5-GNB/G-PLCB/G-PKC signaling pathway
N00433  CXCR4-GNB/G-RAC signaling pathway
N00434  HIV gp120 to CXCR4-GNB/G-RAC signaling pathway
N01657  GPCR-PI3K signaling pathway
N01746  CCR/CXCR-GNB/G-PI3K signaling pathway
N01769  CCR5-GNB/G-PLCB/G signaling pathway
N01770  CCR2-GNB/G-PI3K signaling pathway
N01771  CXCR4-GNB/G signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    2790 (GNG10)
   04371 Apelin signaling pathway
    2790 (GNG10)
   04151 PI3K-Akt signaling pathway
    2790 (GNG10)
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    2790 (GNG10)
  09152 Endocrine system
   04926 Relaxin signaling pathway
    2790 (GNG10)
  09156 Nervous system
   04724 Glutamatergic synapse
    2790 (GNG10)
   04727 GABAergic synapse
    2790 (GNG10)
   04725 Cholinergic synapse
    2790 (GNG10)
   04728 Dopaminergic synapse
    2790 (GNG10)
   04726 Serotonergic synapse
    2790 (GNG10)
   04723 Retrograde endocannabinoid signaling
    2790 (GNG10)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2790 (GNG10)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2790 (GNG10)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    2790 (GNG10)
   05163 Human cytomegalovirus infection
    2790 (GNG10)
   05167 Kaposi sarcoma-associated herpesvirus infection
    2790 (GNG10)
  09165 Substance dependence
   05032 Morphine addiction
    2790 (GNG10)
   05034 Alcoholism
    2790 (GNG10)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04031 GTP-binding proteins [BR:hsa04031]
    2790 (GNG10)
GTP-binding proteins [BR:hsa04031]
 Heterotrimeric G-proteins
  Gamma Subunits
   Gamma [OT]
    2790 (GNG10)
SSDB
Motif
Pfam: G-gamma FtsX_ECD
Other DBs
NCBI-GeneID: 2790
NCBI-ProteinID: NP_001017998
OMIM: 604389
HGNC: 4402
Ensembl: ENSG00000242616
UniProt: P50151
LinkDB
Position
9:111661605..111670226
AA seq 68 aa
MSSGASASALQRLVEQLKLEAGVERIKVSQAAAELQQYCMQNACKDALLVGVPAGSNPFR
EPRSCALL
NT seq 207 nt   +upstreamnt  +downstreamnt
atgtcctccggggctagcgcgagcgccctgcagcgcttggtagagcagctcaagttggag
gctggcgtggagaggatcaaggtctctcaggcagctgcagagcttcaacagtactgtatg
cagaatgcctgcaaggatgccctgctggtgggtgttccagctggaagtaaccccttccgg
gagcctagatcctgtgctttactctga

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