KEGG   Homo sapiens (human): 107987478
Entry
107987478         CDS       T01001                                 
Name
(RefSeq) cytochrome P450 2D6-like
  KO
K17712  cytochrome P450 family 2 subfamily D6 [EC:1.14.14.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa01522  Endocrine resistance
hsa04726  Serotonergic synapse
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    107987478
   00982 Drug metabolism - cytochrome P450
    107987478
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    107987478
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    107987478
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    107987478
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     107987478
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP2 family
   107987478
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 107987478
NCBI-ProteinID: XP_016885819
UniProt: Q38LG2
LinkDB
Position
22
AA seq 497 aa
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYSPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVAAGQPRPSHSRV
VSFLVTPSPYELCAVPR
NT seq 1494 nt   +upstreamnt  +downstreamnt
atggggctagaagcactggtgcccctggccgtgatagtggccatcttcctgctcctggtg
gacctgatgcaccggcgccaacgctgggctgcacgctactcaccaggccccctgccactg
cccgggctgggcaacctgctgcatgtggacttccagaacacaccatactgcttcgaccag
ttgcggcgccgcttcggggacgtgttcagcctgcagctggcctggacgccggtggtcgtg
ctcaatgggctggcggccgtgcgcgaggcgctggtgacccacggcgaggacaccgccgac
cgcccgcctgtgcccatcacccagatcctgggttttgggccgcgttcccaaggggtgttc
ctggcgcgctatgggcccgcgtggcgcgagcagaggcgcttctccgtctccaccttgcgc
aacttgggcctgggcaagaagtcgctggagcagtgggtgaccgaggaggccgcctgcctt
tgtgccgccttcgccaaccactccggacgcccctttcgccccaacggtctcttggacaaa
gccgtgagcaacgtgatcgcctccctcacctgcgggcgccgcttcgagtacgacgaccct
cgcttcctcaggctgctggacctagctcaggagggactgaaggaggagtcgggctttctg
cgcgaggtgctgaatgctgtccccgtcctcctgcatatcccagcgctggctggcaaggtc
ctacgcttccaaaaggctttcctgacccagctggatgagctgctaactgagcacaggatg
acctgggacccagcccagcccccccgagacctgactgaggccttcctggcagagatggag
aaggccaaggggaaccctgagagcagcttcaatgatgagaacctgcgcatagtggtggct
gacctgttctctgccgggatggtgaccacctcgaccacgctggcctggggcctcctgctc
atgatcctacatccggatgtgcagcgccgtgtccaacaggagatcgacgacgtgataggg
caggtgcggcgaccagagatgggtgaccaggctcacatgccctacaccactgccgtgatt
catgaggtgcagcgctttggggacatcgtccccctgggtgtgacccatatgacatcccgt
gacatcgaagtacagggcttccgcatccctaagggaacgacactcatcaccaacctgtca
tcggtgctgaaggatgaggccgtctgggagaagcccttccgcttccaccccgaacacttc
ctggatgcccagggccactttgtgaagccggaggccttcctgcctttctcagcaggccgc
cgtgcatgcctcggggagcccctggcccgcatggagctcttcctcttcttcacctccctg
ctgcagcacttcagcttctccgtggccgccggacagccccggcccagccactctcgtgtc
gtcagctttctggtgaccccatccccctatgagctttgtgctgtgccccgctag

KEGG   Homo sapiens (human): 107987479
Entry
107987479         CDS       T01001                                 
Symbol
CYP2D6
Name
(RefSeq) cytochrome P450 2D6
  KO
K17712  cytochrome P450 family 2 subfamily D6 [EC:1.14.14.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa01522  Endocrine resistance
hsa04726  Serotonergic synapse
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    107987479 (CYP2D6)
   00982 Drug metabolism - cytochrome P450
    107987479 (CYP2D6)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    107987479 (CYP2D6)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    107987479 (CYP2D6)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    107987479 (CYP2D6)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     107987479 (CYP2D6)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP2 family
   107987479 (CYP2D6)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 107987479
NCBI-ProteinID: XP_016885820
UniProt: Q38LG2
LinkDB
Position
22
AA seq 497 aa
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYSPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVAAGQPRPSHSRV
VSFLVTPSPYELCAVPR
NT seq 1494 nt   +upstreamnt  +downstreamnt
atggggctagaagcactggtgcccctggccgtgatagtggccatcttcctgctcctggtg
gacctgatgcaccggcgccaacgctgggctgcacgctactcaccaggccccctgccactg
cccgggctgggcaacctgctgcatgtggacttccagaacacaccatactgcttcgaccag
ttgcggcgccgcttcggggacgtgttcagcctgcagctggcctggacgccggtggtcgtg
ctcaatgggctggcggccgtgcgcgaggcgctggtgacccacggcgaggacaccgccgac
cgcccgcctgtgcccatcacccagatcctgggttttgggccgcgttcccaaggggtgttc
ctggcgcgctatgggcccgcgtggcgcgagcagaggcgcttctccgtctccaccttgcgc
aacttgggcctgggcaagaagtcgctggagcagtgggtgaccgaggaggccgcctgcctt
tgtgccgccttcgccaaccactccggacgcccctttcgccccaacggtctcttggacaaa
gccgtgagcaacgtgatcgcctccctcacctgcgggcgccgcttcgagtacgacgaccct
cgcttcctcaggctgctggacctagctcaggagggactgaaggaggagtcgggctttctg
cgcgaggtgctgaatgctgtccccgtcctcctgcatatcccagcgctggctggcaaggtc
ctacgcttccaaaaggctttcctgacccagctggatgagctgctaactgagcacaggatg
acctgggacccagcccagcccccccgagacctgactgaggccttcctggcagagatggag
aaggccaaggggaaccctgagagcagcttcaatgatgagaacctgcgcatagtggtggct
gacctgttctctgccgggatggtgaccacctcgaccacgctggcctggggcctcctgctc
atgatcctacatccggatgtgcagcgccgtgtccaacaggagatcgacgacgtgataggg
caggtgcggcgaccagagatgggtgaccaggctcacatgccctacaccactgccgtgatt
catgaggtgcagcgctttggggacatcgtccccctgggtgtgacccatatgacatcccgt
gacatcgaagtacagggcttccgcatccctaagggaacgacactcatcaccaacctgtca
tcggtgctgaaggatgaggccgtctgggagaagcccttccgcttccaccccgaacacttc
ctggatgcccagggccactttgtgaagccggaggccttcctgcctttctcagcaggccgc
cgtgcatgcctcggggagcccctggcccgcatggagctcttcctcttcttcacctccctg
ctgcagcacttcagcttctccgtggccgccggacagccccggcccagccactctcgtgtc
gtcagctttctggtgaccccatccccctatgagctttgtgctgtgccccgctag

KEGG   Homo sapiens (human): 1564
Entry
1564              CDS       T01001                                 
Symbol
CYP2D7, CYP2D, CYP2D6, CYP2D7AP, CYP2D7P, CYP2D7P1, CYP2D@, P450C2D, P450DB1, RNA40057
Name
(RefSeq) cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)
  KO
K17712  cytochrome P450 family 2 subfamily D6 [EC:1.14.14.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa01522  Endocrine resistance
hsa04726  Serotonergic synapse
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    1564 (CYP2D7)
   00982 Drug metabolism - cytochrome P450
    1564 (CYP2D7)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    1564 (CYP2D7)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    1564 (CYP2D7)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    1564 (CYP2D7)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     1564 (CYP2D7)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP2 family
   1564 (CYP2D7)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 1564
NCBI-ProteinID: NP_001335315
HGNC: 2624
UniProt: A0A087X1C5
LinkDB
Position
22:complement(42139576..42144483)
AA seq 516 aa
MGLEALVPLAMIVAIFLLLVDLMHRHQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREAMVTRGEDTADRPPAPIYQVLGFGPRSQGVI
LSRYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFADQAGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLPHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAKKEKAKGSPESSFNDENLRIVVG
NLFLAGMVTTSTTLAWGLLLMILHLDVQRGRRVSPGCSPIVGTHVCPVRVQQEIDDVIGQ
VRRPEMGDQAHMPCTTAVIHEVQHFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS
VLKDEAVWKKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLL
QHFSFSVAAGQPRPSHSRVVSFLVTPSPYELCAVPR
NT seq 1551 nt   +upstreamnt  +downstreamnt
atggggctagaagcactggtgcccctggccatgatagtggccatcttcctgctcctggtg
gacctgatgcaccggcaccaacgctgggctgcacgctacccgccaggtcccctgccactg
cccgggctgggcaacctgctgcatgtggacttccagaacacaccatactgcttcgaccag
ttgcggcgccgcttcggggacgtgttcagcctgcagctggcctggacgccggtggtcgtg
ctcaatgggctggcggccgtgcgcgaggcgatggtgacccgcggcgaggacacggccgac
cgcccgcctgcgcccatctaccaggtcctgggcttcgggccgcgttcccaaggggtgatc
ctgtcgcgctatgggcccgcgtggcgcgagcagaggcgcttctccgtgtccaccttgcgc
aacttgggcctgggcaagaagtcgctggagcagtgggtgaccgaggaggccgcctgcctt
tgtgccgccttcgccgaccaagccggacgcccctttcgccccaacggcctcttggacaaa
gccgtgagcaacgtgatcgcctccctcacctgcgggcgccgcttcgagtacgacgaccct
cgcttcctcaggctgctggacctagctcaggagggactgaaggaggagtcgggcttcctg
cgcgaggtgctgaatgctgtccccgtcctcccgcacatcccagcgctggctggcaaggtc
ctacgcttccaaaaggctttcctgacccagctggatgagctgctaactgagcacaggatg
acctgggacccagcccagccaccccgagacctgactgaggccttcctggcaaagaaggag
aaggccaaggggagccctgagagcagcttcaatgatgagaacctgcgcatagtggtgggt
aacctgttccttgccgggatggtgaccacctcgaccacgctggcctggggcctcctgctc
atgatcctacacctggatgtgcagcgaggaaggagagtgtcccctgggtgctcacccatt
gtggggacgcatgtctgtccagtccgtgtccaacaggagatcgacgacgtgatagggcag
gtgcggcgaccagagatgggtgaccaggctcacatgccctgcaccactgccgtgattcac
gaggtgcagcactttggggacatcgtccccctgggtgtgacccatatgacatcccgtgac
atcgaagtacagggcttccgcatccctaagggaacgacactcatcaccaacctgtcatcg
gtgctgaaggatgaggccgtctggaagaagcccttccgcttccaccccgaacacttcctg
gatgcccagggccactttgtgaagccggaggccttcctgcctttctcagcaggccgccgt
gcatgcctcggggagcccctggcccgcatggagctcttcctcttcttcacctccctgctg
cagcacttcagcttctccgtggccgccggacagccccggcccagccactctcgtgtcgtc
agctttctggtgaccccatccccctacgagctttgtgctgtgccccgctag

KEGG   Homo sapiens (human): 1565
Entry
1565              CDS       T01001                                 
Symbol
CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1
Name
(RefSeq) cytochrome P450 family 2 subfamily D member 6
  KO
K17712  cytochrome P450 family 2 subfamily D6 [EC:1.14.14.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa01522  Endocrine resistance
hsa04726  Serotonergic synapse
Disease
H01171  Poor drug metabolism
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    1565 (CYP2D6)
   00982 Drug metabolism - cytochrome P450
    1565 (CYP2D6)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    1565 (CYP2D6)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    1565 (CYP2D6)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    1565 (CYP2D6)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     1565 (CYP2D6)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP2 family
   1565 (CYP2D6)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 1565
NCBI-ProteinID: NP_000097
OMIM: 124030
HGNC: 2625
Ensembl: ENSG00000100197
Pharos: P10635(Tclin)
UniProt: P10635 C1ID52 Q5Y7H2
Structure
LinkDB
Position
22:complement(42126499..42130810)
AA seq 497 aa
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
NT seq 1494 nt   +upstreamnt  +downstreamnt
atggggctagaagcactggtgcccctggccgtgatagtggccatcttcctgctcctggtg
gacctgatgcaccggcgccaacgctgggctgcacgctacccaccaggccccctgccactg
cccgggctgggcaacctgctgcatgtggacttccagaacacaccatactgcttcgaccag
ttgcggcgccgcttcggggacgtgttcagcctgcagctggcctggacgccggtggtcgtg
ctcaatgggctggcggccgtgcgcgaggcgctggtgacccacggcgaggacaccgccgac
cgcccgcctgtgcccatcacccagatcctgggtttcgggccgcgttcccaaggggtgttc
ctggcgcgctatgggcccgcgtggcgcgagcagaggcgcttctccgtgtccaccttgcgc
aacttgggcctgggcaagaagtcgctggagcagtgggtgaccgaggaggccgcctgcctt
tgtgccgccttcgccaaccactccggacgcccctttcgccccaacggtctcttggacaaa
gccgtgagcaacgtgatcgcctccctcacctgcgggcgccgcttcgagtacgacgaccct
cgcttcctcaggctgctggacctagctcaggagggactgaaggaggagtcgggctttctg
cgcgaggtgctgaatgctgtccccgtcctcctgcatatcccagcgctggctggcaaggtc
ctacgcttccaaaaggctttcctgacccagctggatgagctgctaactgagcacaggatg
acctgggacccagcccagcccccccgagacctgactgaggccttcctggcagagatggag
aaggccaaggggaaccctgagagcagcttcaatgatgagaacctgcgcatagtggtggct
gacctgttctctgccgggatggtgaccacctcgaccacgctggcctggggcctcctgctc
atgatcctacatccggatgtgcagcgccgtgtccaacaggagatcgacgacgtgataggg
caggtgcggcgaccagagatgggtgaccaggctcacatgccctacaccactgccgtgatt
catgaggtgcagcgctttggggacatcgtccccctgggtgtgacccatatgacatcccgt
gacatcgaagtacagggcttccgcatccctaagggaacgacactcatcaccaacctgtca
tcggtgctgaaggatgaggccgtctgggagaagcccttccgcttccaccccgaacacttc
ctggatgcccagggccactttgtgaagccggaggccttcctgcctttctcagcaggccgc
cgtgcatgcctcggggagcccctggcccgcatggagctcttcctcttcttcacctccctg
ctgcagcacttcagcttctcggtgcccactggacagccccggcccagccaccatggtgtc
tttgctttcctggtgagcccatccccctatgagctttgtgctgtgccccgctag

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