Homo sapiens (human): 10919
Help
Entry
10919 CDS
T01001
Symbol
EHMT2, BAT8, C6orf30, G9A, GAT8, KMT1C, NG36
Name
(RefSeq) euchromatic histone lysine methyltransferase 2
KO
K11420
[histone H3]-lysine9 N-trimethyltransferase EHMT [EC:
2.1.1.355
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00310
Lysine degradation
hsa01100
Metabolic pathways
hsa04211
Longevity regulating pathway
Network
nt06523
Epigenetic regulation by Polycomb complexes
Element
N01614
Activation of PRC2.2 by ubiquitination of H2AK119 in germline genes
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
10919 (EHMT2)
09150 Organismal Systems
09149 Aging
04211 Longevity regulating pathway
10919 (EHMT2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
hsa03036
]
10919 (EHMT2)
Enzymes [BR:
hsa01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.355 [histone H3]-lysine9 N-trimethyltransferase
10919 (EHMT2)
Chromosome and associated proteins [BR:
hsa03036
]
Eukaryotic type
Histone modification proteins
HDAC complexes
REST complex
10919 (EHMT2)
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
10919 (EHMT2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Ank
Ank_2
EHMT1-2_CRR
Ank_4
Ank_3
SET
Ank_5
Pre-SET
ANK_LRRK2
CDC45
PRDM2_PR
ARM_KRIT1
Paf1
Sporozoite_P67
Nop14
Motif
Other DBs
NCBI-GeneID:
10919
NCBI-ProteinID:
NP_006700
OMIM:
604599
HGNC:
14129
Ensembl:
ENSG00000204371
UniProt:
Q96KQ7
A0A024RCN9
Structure
PDB
PDBj
LinkDB
All DBs
Position
6:complement(31879759..31897698)
Genome browser
AA seq
1210 aa
AA seq
DB search
MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE
PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP
SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV
HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL
GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE
EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR
KREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGF
EELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVL
CETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDA
SEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLA
DTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQ
GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT
PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA
QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNA
RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFA
LQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETS
TMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQA
CSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVR
EDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFS
SRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLP
ELGSLPPVNT
NT seq
3633 nt
NT seq
+upstream
nt +downstream
nt
atggcggcggcggcgggagctgcagcggcggcggccgccgagggggaggcccccgctgag
atgggggcgctgctgctggagaaggaaaccagaggagccaccgagagagttcatggctct
ttgggggacacccctcgtagtgaagaaaccctgcccaaggccacccccgactccctggag
cctgctggcccctcatctccagcctctgtcactgtcactgttggtgatgagggggctgac
acccctgtaggggctacaccactcattggggatgaatctgagaatcttgagggagatggg
gacctccgtgggggccggatcctgctgggccatgccacaaagtcattcccctcttccccc
agcaaggggggttcctgtcctagccgggccaagatgtcaatgacaggggcgggaaaatca
cctccatctgtccagagtttggctatgaggctactgagtatgccaggagcccagggagct
gcagcagcagggtctgaaccccctccagccaccacgagcccagagggacagcccaaggtc
caccgagcccgcaaaaccatgtccaaaccaggaaatggacagcccccggtccctgagaag
cggccccctgaaatacagcatttccgcatgagtgatgatgtccactcactgggaaaggtg
acctcagatctggccaaaaggaggaagctgaactcaggaggtggcctgtcagaggagtta
ggttctgcccggcgttcaggagaagtgaccctgacgaaaggggaccccgggtccctggag
gagtgggagacggtggtgggtgatgacttcagtctctactatgattcctactctgtggat
gagcgcgtggactccgacagcaagtctgaagttgaagctctaactgaacaactaagtgaa
gaggaggaggaggaagaggaggaagaagaagaagaggaagaggaggaggaagaggaagaa
gaagaggaagatgaggagtcagggaatcagtcagataggagtggttccagtggccggcgc
aaggccaagaagaaatggcgaaaagacagcccatgggtgaagccgtctcggaaacggcgc
aagcgggagcctccgcgggccaaggagccacgaggagtgaatggtgtgggctcctcaggc
cccagtgagtacatggaggtccctctggggtccctggagctgcccagcgaggggaccctc
tcccccaaccacgctggggtgtccaatgacacatcttcgctggagacagagcgagggttt
gaggagttgcccctgtgcagctgccgcatggaggcacccaagattgaccgcatcagcgag
agggcggggcacaagtgcatggccactgagagtgtggacggagagctgtcaggctgcaat
gccgccatcctcaagcgggagaccatgaggccatccagccgtgtggccctgatggtgctc
tgtgagacccaccgcgcccgcatggtcaaacaccactgctgcccgggctgcggctacttc
tgcacggcgggcaccttcctggagtgccaccctgacttccgtgtggcccaccgcttccac
aaggcctgtgtgtctcagctgaatgggatggtcttctgtccccactgtggggaggatgct
tctgaagctcaagaggtgaccatcccccggggtgacggggtgaccccaccggccggcact
gcagctcctgcacccccacccctgtcccaggatgtccccgggagagcagacacttctcag
cccagtgcccggatgcgagggcatggggaaccccggcgcccgccctgcgatcccctggct
gacaccattgacagctcagggccctccctgaccctgcccaatgggggctgcctttcagcc
gtggggctgccactggggccaggccgggaggccctggaaaaggccctggtcatccaggag
tcagagaggcggaagaagctccgtttccaccctcggcagttgtacctgtccgtgaagcag
ggcgagctgcagaaggtgatcctgatgctgttggacaacctggaccccaacttccagagc
gaccagcagagcaagcgcacgcccctgcatgcagccgcccagaagggctccgtggagatc
tgccatgtgctgctgcaggctggagccaacataaatgcagtggacaaacagcagcggacg
ccactgatggaggccgtggtgaacaaccacctggaggtagcccgttacatggtgcagcgt
ggtggctgtgtctatagcaaggaggaggacggttccacctgcctccaccacgcagccaaa
atcgggaacttggagatggtcagcctgctgctgagcacaggacaggtggacgtcaacgcc
caggacagtggggggtggacgcccatcatctgggctgcagagcacaagcacatcgaggtg
atccgcatgctactgacgcggggcgccgacgtcaccctcactgacaacgaggagaacatc
tgcctgcactgggcctccttcacgggcagcgccgccatcgccgaagtccttctgaatgcg
cgctgtgacctccatgctgtcaactaccatggggacacccccctgcacatcgcagctcgg
gagagctaccatgactgcgtgctgttattcctgtcacgtggggccaaccctgagctgcgg
aacaaagagggggacacagcatgggacctgactcccgagcgctccgacgtgtggtttgcg
cttcaactcaaccgcaagctccgacttggggtgggaaatcgggccatccgcacagagaag
atcatctgccgggacgtggctcggggctatgagaacgtgcccattccctgtgtcaacggt
gtggatggggagccctgccctgaggattacaagtacatctcagagaactgcgagacgtcc
accatgaacatcgatcgcaacatcacccacctgcagcactgcacgtgtgtggacgactgc
tctagctccaactgcctgtgcggccagctcagcatccggtgctggtatgacaaggatggg
cgattgctccaggaatttaacaagattgagcctccgctgattttcgagtgtaaccaggcg
tgctcatgctggagaaactgcaagaaccgggtcgtacagagtggcatcaaggtgcggcta
cagctctaccgaacagccaagatgggctggggggtccgcgccctgcagaccatcccacag
gggaccttcatctgcgagtatgtcggggagctgatctctgatgctgaggctgatgtgaga
gaggatgattcttacctcttcgacttagacaacaaggatggagaggtgtactgcatagat
gcccgttactatggcaacatcagccgcttcatcaaccacctgtgtgaccccaacatcatt
cccgtccgggtcttcatgctgcaccaagacctgcgatttccacgcatcgccttcttcagt
tcccgagacatccggactggggaggagctagggtttgactatggcgaccgcttctgggac
atcaaaagcaaatatttcacctgccaatgtggctctgagaagtgcaagcactcagccgaa
gccattgccctggagcagagccgtctggcccgcctggacccacaccctgagctgctgccc
gagctcggctccctgccccctgtcaacacatga
Homo sapiens (human): 79813
Help
Entry
79813 CDS
T01001
Symbol
EHMT1, EHMT1-IT1, EUHMTASE1, Eu-HMTase1, FP13812, GLP, GLP1, KLEFS1, KMT1D
Name
(RefSeq) euchromatic histone lysine methyltransferase 1
KO
K11420
[histone H3]-lysine9 N-trimethyltransferase EHMT [EC:
2.1.1.355
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00310
Lysine degradation
hsa01100
Metabolic pathways
hsa04211
Longevity regulating pathway
Network
nt06523
Epigenetic regulation by Polycomb complexes
Element
N01614
Activation of PRC2.2 by ubiquitination of H2AK119 in germline genes
Disease
H00907
Kleefstra syndrome
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
79813 (EHMT1)
09150 Organismal Systems
09149 Aging
04211 Longevity regulating pathway
79813 (EHMT1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
hsa03036
]
79813 (EHMT1)
Enzymes [BR:
hsa01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.355 [histone H3]-lysine9 N-trimethyltransferase
79813 (EHMT1)
Chromosome and associated proteins [BR:
hsa03036
]
Eukaryotic type
Histone modification proteins
HDAC complexes
REST complex
79813 (EHMT1)
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
79813 (EHMT1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Ank_2
Ank
Ank_4
EHMT1-2_CRR
Ank_3
Ank_5
SET
Pre-SET
ARM_KRIT1
ANK_LRRK2
Motif
Other DBs
NCBI-GeneID:
79813
NCBI-ProteinID:
NP_079033
OMIM:
607001
HGNC:
24650
Ensembl:
ENSG00000181090
UniProt:
Q9H9B1
Structure
PDB
PDBj
LinkDB
All DBs
Position
9:137619005..137836127
Genome browser
AA seq
1298 aa
AA seq
DB search
MAAADAEAVPARGEPQQDCCVKTELLGEETPMAADEGSAEKQAGEAHMAADGETNGSCEN
SDASSHANAAKHTQDSARVNPQDGTNTLTRIAENGVSERDSEAAKQNHVTADDFVQTSVI
GSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRTPSAFPQTPAAPPATLG
EGSADTEDRKLPAPGADVKVHRARKTMPKSVVGLHAASKDPREVREARDHKEPKEEINKN
ISDFGRQQLLPPFPSLHQSLPQNQCYMATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVP
KKKTKVLKQRTVIEMFKSITHSTVGSKGEKDLGASSLHVNGESLEMDSDEDDSEELEEDD
GHGAEQAAAFPTEDSRTSKESMSEADRAQKMDGESEEEQESVDTGEEEEGGDESDLSSES
SIKKKFLKRKGKTDSPWIKPARKRRRRSRKKPSGALGSESYKSSAGSAEQTAPGDSTGYM
EVSLDSLDLRVKGILSSQAEGLANGPDVLETDGLQEVPLCSCRMETPKSREITTLANNQC
MATESVDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNF
MECQPESSISHRFHKDCASRVNNASYCPHCGEESSKAKEVTIAKADTTSTVTPVPGQEKG
SALEGRADTTTGSAAGPPLSEDDKLQGAASHVPEGFDPTGPAGLGRPTPGLSQGPGKETL
ESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAA
AEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGS
TCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDIN
IRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLS
RDSDVTLKNKEGETPLQCASLNSQVWSALQMSKALQDSAPDRPSPVERIVSRDIARGYER
IPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSM
RCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGV
RSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFIN
HHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGS
PKCRHSSAALAQRQASAAQEAQEDGLPDTSSAAAADPL
NT seq
3897 nt
NT seq
+upstream
nt +downstream
nt
atggccgccgccgatgccgaggcagttccggcgaggggggagcctcagcaggattgctgt
gtgaaaaccgagctgctgggagaagagacacctatggctgccgatgaaggctcagcagag
aaacaggcaggagaggcccacatggctgcggacggtgagaccaatgggtcttgtgaaaac
agcgatgccagcagtcatgcaaatgctgcaaagcacactcaggacagcgcaagggtcaac
ccccaggatggcaccaacacactaactcggatagcggaaaatggggtttcagaaagagac
tcagaagcggcgaagcaaaaccacgtcactgccgacgactttgtgcagacttctgtcatc
ggcagcaacggatacatcttaaataagccggccctacaggcacagcccttgaggactacc
agcactctggcctcttcgctgcctggccatgctgcaaaaacccttcctggaggggctggc
aaaggcaggactccaagcgcttttccccagacgccagccgccccaccagccacccttggg
gaggggagtgctgacacagaggacaggaagctcccggcccctggcgccgacgtcaaggtc
cacagggcacgcaagaccatgccgaagtccgtcgtgggcctgcatgcagccagtaaagat
cccagagaagttcgagaagctagagatcataaggaaccaaaagaggagatcaacaaaaac
atttctgactttggacgacagcagcttttaccccccttcccatcccttcatcagtcgcta
cctcagaaccagtgctacatggccaccacaaaatcacagacagcttgcttgccttttgtt
ttagcagctgcagtatctcggaagaaaaaacgaagaatgggaacctatagcctggttcct
aagaaaaagaccaaagtattaaaacagaggacggtgattgagatgtttaagagcataact
cattccactgtgggttccaagggggagaaggacctgggcgccagcagcctgcacgtgaat
ggggagagcctggagatggactcggatgaggacgactcagaggagctcgaggaggacgac
ggccatggtgcagagcaggcggccgcgttccccacagaggacagcaggacttccaaggag
agcatgtcggaggctgatcgcgcccagaagatggacggggagtccgaggaggagcaggag
tccgtggacaccggggaggaggaggaaggcggtgacgagtctgacctgagttcggaatcc
agcattaagaagaaatttctcaagaggaaaggaaagaccgacagtccctggatcaagcca
gccaggaaaaggaggcggagaagtagaaagaagcccagcggtgccctcggttctgagtcg
tataagtcatctgcaggaagcgctgagcagacggcaccaggagacagcacagggtacatg
gaagtttctctggactccctggatctccgagtcaaaggaattctgtcttcacaagcagaa
gggttggccaacggtccagatgtgctggagacagacggcctccaggaagtgcctctctgc
agctgccggatggaaacaccgaagagtcgagagatcaccacactggccaacaaccagtgc
atggctacagagagcgtggaccatgaattgggccggtgcacaaacagcgtggtcaagtat
gagctgatgcgcccctccaacaaggccccgctcctcgtgctgtgtgaagaccaccggggc
cgcatggtgaagcaccagtgctgtcctggctgtggctacttctgcacagcgggtaatttt
atggagtgtcagcccgagagcagcatctctcaccgtttccacaaagactgtgcctctcga
gtcaataacgccagctattgtccccactgtggggaggagagctccaaggccaaagaggtg
acgatagctaaagcagacaccacctcgaccgtgacaccagtccccgggcaggagaagggc
tcggccctggagggcagggccgacaccacaacgggcagtgctgccgggccaccactctcg
gaggacgacaagctgcagggtgcagcctcccacgtgcccgagggctttgatccaacggga
cctgctgggcttgggaggccaactcccggcctttcccagggaccagggaaggaaaccttg
gagagcgctctcatcgccctcgactcggaaaaacccaagaagcttcgcttccacccaaag
cagctgtacttctccgccaggcaaggggagcttcagaaggtgctcctcatgctggtggac
ggaattgaccccaacttcaaaatggagcaccagaataagcgctctccactgcacgccgcg
gcagaggctggacacgtggacatctgccacatgctggttcaggcgggcgctaatattgac
acctgctcagaagaccagaggaccccgttgatggaagcagccgaaaacaaccatctggaa
gcagtgaagtacctcatcaaggctggggccctggtggatcccaaggacgcagagggctct
acgtgtttgcacctggctgccaagaaaggccactacgaagtggtccagtacctgctttca
aatggacagatggacgtcaactgtcaggatgacggaggctggacacccatgatctgggcc
acagagtacaagcacgtggacctcgtgaagctgctgctgtccaagggctctgacatcaac
atccgagacaacgaggagaacatttgcctgcactgggcggcgttctccggctgcgtggac
atagccgagatcctgctggctgccaagtgcgacctccacgccgtgaacatccacggagac
tcgccactgcacattgccgcccgggagaaccgctacgactgtgtcgtcctctttctttct
cgggattcagatgtcaccttaaagaacaaggaaggagagacgcccctgcagtgtgcgagc
ctcaactctcaggtgtggagcgctctgcagatgagcaaggctctgcaggactcggccccc
gacaggcccagccccgtggagaggatagtgagcagggacatcgctcgaggctacgagcgc
atccccatcccctgtgtcaacgccgtggacagcgagccatgccccagcaactacaagtac
gtctctcagaactgcgtgacgtcccccatgaacatcgacagaaatatcactcatctgcag
tactgcgtgtgcatcgacgactgctcctccagcaactgcatgtgcggccagctcagcatg
cgctgctggtacgacaaggatggccggctcctgccagagttcaacatggcggagcctccc
ttgatcttcgaatgcaaccacgcgtgctcctgctggaggaactgccgaaatcgcgtcgta
cagaatggtctcagggcaaggctgcagctctaccggacgcgggacatgggctggggcgtg
cggtccctgcaggacatcccaccaggcacctttgtctgcgagtatgttggggagctgatt
tcagactcagaagccgacgttcgagaggaagattcttacctctttgatctcgacaataag
gacggggaggtttactgcatcgacgcgcggttctacgggaacgtcagccggttcatcaac
caccactgcgagcccaacctggtgcccgtgcgcgtgttcatggcccaccaggacctgcgg
ttcccccggatcgccttcttcagcacccgcctgatcgaggccggcgagcagctcgggttt
gactatggagagcgcttctgggacatcaaaggcaagctcttcagctgccgctgcggctcc
cccaagtgccggcactcgagcgcggccctggcccagcgtcaggccagcgcggcccaggag
gcccaggaggacggcttgcccgacaccagctccgcggctgccgccgaccccctatga
DBGET
integrated database retrieval system
