KEGG   Homo sapiens (human): 110117499
Entry
110117499         CDS       T01001                                 
Symbol
P3R3URF-PIK3R3, LOC110117498-PIK3R3
Name
(RefSeq) P3R3URF-PIK3R3 readthrough
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa01524  Platinum drug resistance
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04024  cAMP signaling pathway
hsa04062  Chemokine signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04068  FoxO signaling pathway
hsa04070  Phosphatidylinositol signaling system
hsa04071  Sphingolipid signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04081  Hormone signaling
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04210  Apoptosis
hsa04211  Longevity regulating pathway
hsa04213  Longevity regulating pathway - multiple species
hsa04218  Cellular senescence
hsa04360  Axon guidance
hsa04370  VEGF signaling pathway
hsa04380  Osteoclast differentiation
hsa04510  Focal adhesion
hsa04517  IgSF CAM signaling
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04611  Platelet activation
hsa04613  Neutrophil extracellular trap formation
hsa04620  Toll-like receptor signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa04668  TNF signaling pathway
hsa04670  Leukocyte transendothelial migration
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
hsa04917  Prolactin signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa04923  Regulation of lipolysis in adipocytes
hsa04926  Relaxin signaling pathway
hsa04929  GnRH secretion
hsa04930  Type II diabetes mellitus
hsa04931  Insulin resistance
hsa04932  Non-alcoholic fatty liver disease
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04935  Growth hormone synthesis, secretion and action
hsa04960  Aldosterone-regulated sodium reabsorption
hsa04973  Carbohydrate digestion and absorption
hsa05010  Alzheimer disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05100  Bacterial invasion of epithelial cells
hsa05131  Shigellosis
hsa05135  Yersinia infection
hsa05142  Chagas disease
hsa05146  Amoebiasis
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05162  Measles
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05171  Coronavirus disease - COVID-19
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05218  Melanoma
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05222  Small cell lung cancer
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05230  Central carbon metabolism in cancer
hsa05231  Choline metabolism in cancer
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05415  Diabetic cardiomyopathy
hsa05417  Lipid and atherosclerosis
hsa05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    110117499 (P3R3URF-PIK3R3)
   04014 Ras signaling pathway
    110117499 (P3R3URF-PIK3R3)
   04015 Rap1 signaling pathway
    110117499 (P3R3URF-PIK3R3)
   04370 VEGF signaling pathway
    110117499 (P3R3URF-PIK3R3)
   04630 JAK-STAT signaling pathway
    110117499 (P3R3URF-PIK3R3)
   04668 TNF signaling pathway
    110117499 (P3R3URF-PIK3R3)
   04066 HIF-1 signaling pathway
    110117499 (P3R3URF-PIK3R3)
   04068 FoxO signaling pathway
    110117499 (P3R3URF-PIK3R3)
   04070 Phosphatidylinositol signaling system
    110117499 (P3R3URF-PIK3R3)
   04072 Phospholipase D signaling pathway
    110117499 (P3R3URF-PIK3R3)
   04071 Sphingolipid signaling pathway
    110117499 (P3R3URF-PIK3R3)
   04024 cAMP signaling pathway
    110117499 (P3R3URF-PIK3R3)
   04151 PI3K-Akt signaling pathway
    110117499 (P3R3URF-PIK3R3)
   04152 AMPK signaling pathway
    110117499 (P3R3URF-PIK3R3)
   04150 mTOR signaling pathway
    110117499 (P3R3URF-PIK3R3)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    110117499 (P3R3URF-PIK3R3)
   04517 IgSF CAM signaling
    110117499 (P3R3URF-PIK3R3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    110117499 (P3R3URF-PIK3R3)
  09143 Cell growth and death
   04210 Apoptosis
    110117499 (P3R3URF-PIK3R3)
   04218 Cellular senescence
    110117499 (P3R3URF-PIK3R3)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    110117499 (P3R3URF-PIK3R3)
   04550 Signaling pathways regulating pluripotency of stem cells
    110117499 (P3R3URF-PIK3R3)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    110117499 (P3R3URF-PIK3R3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    110117499 (P3R3URF-PIK3R3)
   04613 Neutrophil extracellular trap formation
    110117499 (P3R3URF-PIK3R3)
   04620 Toll-like receptor signaling pathway
    110117499 (P3R3URF-PIK3R3)
   04625 C-type lectin receptor signaling pathway
    110117499 (P3R3URF-PIK3R3)
   04650 Natural killer cell mediated cytotoxicity
    110117499 (P3R3URF-PIK3R3)
   04660 T cell receptor signaling pathway
    110117499 (P3R3URF-PIK3R3)
   04662 B cell receptor signaling pathway
    110117499 (P3R3URF-PIK3R3)
   04664 Fc epsilon RI signaling pathway
    110117499 (P3R3URF-PIK3R3)
   04666 Fc gamma R-mediated phagocytosis
    110117499 (P3R3URF-PIK3R3)
   04670 Leukocyte transendothelial migration
    110117499 (P3R3URF-PIK3R3)
   04062 Chemokine signaling pathway
    110117499 (P3R3URF-PIK3R3)
  09152 Endocrine system
   04910 Insulin signaling pathway
    110117499 (P3R3URF-PIK3R3)
   04923 Regulation of lipolysis in adipocytes
    110117499 (P3R3URF-PIK3R3)
   04929 GnRH secretion
    110117499 (P3R3URF-PIK3R3)
   04915 Estrogen signaling pathway
    110117499 (P3R3URF-PIK3R3)
   04914 Progesterone-mediated oocyte maturation
    110117499 (P3R3URF-PIK3R3)
   04917 Prolactin signaling pathway
    110117499 (P3R3URF-PIK3R3)
   04926 Relaxin signaling pathway
    110117499 (P3R3URF-PIK3R3)
   04935 Growth hormone synthesis, secretion and action
    110117499 (P3R3URF-PIK3R3)
   04919 Thyroid hormone signaling pathway
    110117499 (P3R3URF-PIK3R3)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    110117499 (P3R3URF-PIK3R3)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    110117499 (P3R3URF-PIK3R3)
  09156 Nervous system
   04725 Cholinergic synapse
    110117499 (P3R3URF-PIK3R3)
   04722 Neurotrophin signaling pathway
    110117499 (P3R3URF-PIK3R3)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    110117499 (P3R3URF-PIK3R3)
  09158 Development and regeneration
   04360 Axon guidance
    110117499 (P3R3URF-PIK3R3)
   04380 Osteoclast differentiation
    110117499 (P3R3URF-PIK3R3)
  09149 Aging
   04211 Longevity regulating pathway
    110117499 (P3R3URF-PIK3R3)
   04213 Longevity regulating pathway - multiple species
    110117499 (P3R3URF-PIK3R3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    110117499 (P3R3URF-PIK3R3)
   05206 MicroRNAs in cancer
    110117499 (P3R3URF-PIK3R3)
   05205 Proteoglycans in cancer
    110117499 (P3R3URF-PIK3R3)
   05207 Chemical carcinogenesis - receptor activation
    110117499 (P3R3URF-PIK3R3)
   05208 Chemical carcinogenesis - reactive oxygen species
    110117499 (P3R3URF-PIK3R3)
   05203 Viral carcinogenesis
    110117499 (P3R3URF-PIK3R3)
   05230 Central carbon metabolism in cancer
    110117499 (P3R3URF-PIK3R3)
   05231 Choline metabolism in cancer
    110117499 (P3R3URF-PIK3R3)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    110117499 (P3R3URF-PIK3R3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    110117499 (P3R3URF-PIK3R3)
   05212 Pancreatic cancer
    110117499 (P3R3URF-PIK3R3)
   05225 Hepatocellular carcinoma
    110117499 (P3R3URF-PIK3R3)
   05226 Gastric cancer
    110117499 (P3R3URF-PIK3R3)
   05214 Glioma
    110117499 (P3R3URF-PIK3R3)
   05221 Acute myeloid leukemia
    110117499 (P3R3URF-PIK3R3)
   05220 Chronic myeloid leukemia
    110117499 (P3R3URF-PIK3R3)
   05218 Melanoma
    110117499 (P3R3URF-PIK3R3)
   05211 Renal cell carcinoma
    110117499 (P3R3URF-PIK3R3)
   05215 Prostate cancer
    110117499 (P3R3URF-PIK3R3)
   05213 Endometrial cancer
    110117499 (P3R3URF-PIK3R3)
   05224 Breast cancer
    110117499 (P3R3URF-PIK3R3)
   05222 Small cell lung cancer
    110117499 (P3R3URF-PIK3R3)
   05223 Non-small cell lung cancer
    110117499 (P3R3URF-PIK3R3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    110117499 (P3R3URF-PIK3R3)
   05170 Human immunodeficiency virus 1 infection
    110117499 (P3R3URF-PIK3R3)
   05161 Hepatitis B
    110117499 (P3R3URF-PIK3R3)
   05160 Hepatitis C
    110117499 (P3R3URF-PIK3R3)
   05171 Coronavirus disease - COVID-19
    110117499 (P3R3URF-PIK3R3)
   05164 Influenza A
    110117499 (P3R3URF-PIK3R3)
   05162 Measles
    110117499 (P3R3URF-PIK3R3)
   05168 Herpes simplex virus 1 infection
    110117499 (P3R3URF-PIK3R3)
   05163 Human cytomegalovirus infection
    110117499 (P3R3URF-PIK3R3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    110117499 (P3R3URF-PIK3R3)
   05169 Epstein-Barr virus infection
    110117499 (P3R3URF-PIK3R3)
   05165 Human papillomavirus infection
    110117499 (P3R3URF-PIK3R3)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    110117499 (P3R3URF-PIK3R3)
   05135 Yersinia infection
    110117499 (P3R3URF-PIK3R3)
   05100 Bacterial invasion of epithelial cells
    110117499 (P3R3URF-PIK3R3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    110117499 (P3R3URF-PIK3R3)
   05142 Chagas disease
    110117499 (P3R3URF-PIK3R3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    110117499 (P3R3URF-PIK3R3)
   05017 Spinocerebellar ataxia
    110117499 (P3R3URF-PIK3R3)
   05020 Prion disease
    110117499 (P3R3URF-PIK3R3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    110117499 (P3R3URF-PIK3R3)
   05418 Fluid shear stress and atherosclerosis
    110117499 (P3R3URF-PIK3R3)
   05415 Diabetic cardiomyopathy
    110117499 (P3R3URF-PIK3R3)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    110117499 (P3R3URF-PIK3R3)
   04932 Non-alcoholic fatty liver disease
    110117499 (P3R3URF-PIK3R3)
   04931 Insulin resistance
    110117499 (P3R3URF-PIK3R3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    110117499 (P3R3URF-PIK3R3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    110117499 (P3R3URF-PIK3R3)
   01524 Platinum drug resistance
    110117499 (P3R3URF-PIK3R3)
   01522 Endocrine resistance
    110117499 (P3R3URF-PIK3R3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    110117499 (P3R3URF-PIK3R3)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    110117499 (P3R3URF-PIK3R3)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 SH2_1 Transcrip_act Cupin_8
Other DBs
NCBI-GeneID: 110117499
NCBI-ProteinID: NP_001290356
HGNC: 54999
Ensembl: ENSG00000278139
UniProt: Q68CY7 B4DXM8 F6TDL0 Q7Z3W2
LinkDB
Position
1:complement(46040140..46176488)
AA seq 507 aa
MGPSRLVRGPRPQGMRSPYRRPGMGWPRPRFPRMFKCSRRRYQQGLRGRTASSAAINPAT
RAMGINNTHTDTTIVWIFPPQALPPKPPKPMTSAVPNGMKDSSVSLQDAEWYWGDISREE
VNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVV
ELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKE
YDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIE
RIMMNYDKLKSRLGEIHDSKMRLEQDLKNQALDNREIDKKMNSIKPDLIQLRKIRDQHLV
WLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYG
KPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQ
TSLVQHNDSLNVRLAYPVHAQMPSLCR
NT seq 1524 nt   +upstreamnt  +downstreamnt
atggggccatctcggcttgtccgtggccctcggccccagggcatgcgttccccctaccgc
aggccaggtatgggctggcccaggccccgatttcccaggatgttcaagtgtagccgcaga
agatatcaacagggtctccgaggtcgaactgccagcagtgcagccatcaatcctgccacc
agggccatgggtatcaacaacacccacactgacaccaccatagtgtggatcttcccacct
caagctcttccaccaaagccacctaagccaatgacttcagcagttccaaatggaatgaag
gacagttctgtttctcttcaggatgcagaatggtactggggggatatttcaagggaggag
gtaaatgacaaattgcgggatatgccagatgggaccttcttggtccgagatgcctcaaca
aaaatgcagggagattatactttgactttgcggaagggaggcaataataagttaataaag
atctatcaccgggatggtaaatatggcttttctgatcctctgacatttaattccgtggtg
gagctcattaaccactatcaccatgaatctcttgctcagtacaatcccaaacttgatgtg
aagctgatgtacccagtgtccagataccaacaggatcagttggtaaaagaagataatatt
gatgcagtaggtaaaaaactgcaagaataccactctcagtatcaggagaagagtaaagag
tatgataggctgtatgaagaatatactagaacatcccaggaaatacagatgaagaggact
gcaatagaagcttttaatgaaacaattaaaatatttgaagagcagtgtcacacacaagaa
caacatagcaaagaatatattgagcgatttcgcagagaggggaatgaaaaggagattgaa
cgaattatgatgaattatgataaattgaaatcacgtctgggtgagattcatgatagcaaa
atgcgtctagagcaggatttgaagaatcaagctttggacaaccgagaaatagataaaaaa
atgaatagcatcaaacctgacctgatccagctgcgaaagatccgagatcaacaccttgta
tggctcaatcacaaaggagtgagacagaaacgcctgaatgtctggctgggaattaagaat
gaggatgctgatgagaactattttatcaatgaggaagatgaaaacctgccccattatgat
gagaaaacctggtttgttgaggatatcaatcgagtacaagcagaggacttgctttatggg
aaacctgatggtgcattcttaattcgtgagagtagcaagaaaggatgctatgcttgctct
gtggtggccgatggggaagtgaagcactgtgtgatctacagcactgctcggggctatggc
tttgcagagccctacaacctgtacagctctctgaaggagctagtgctccattaccagcag
acatccttggttcagcacaacgactccctcaacgtcaggcttgcctaccctgttcatgca
cagatgccctcgctttgcagataa

KEGG   Homo sapiens (human): 5289
Entry
5289              CDS       T01001                                 
Symbol
PIK3C3, VPS34, hVps34
Name
(RefSeq) phosphatidylinositol 3-kinase catalytic subunit type 3
  KO
K00914  phosphatidylinositol 3-kinase [EC:2.7.1.137]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00562  Inositol phosphate metabolism
hsa01100  Metabolic pathways
hsa04070  Phosphatidylinositol signaling system
hsa04136  Autophagy - other
hsa04140  Autophagy - animal
hsa04145  Phagosome
hsa04371  Apelin signaling pathway
hsa05010  Alzheimer disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05152  Tuberculosis
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Network
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06181  Salmonella
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06466  Pathways of neurodegeneration
nt06532  Autophagy
  Element
N00155  Autophagy-vesicle nucleation/elongation/maturation, mTORC1-PI3KC3-C1
N00177  KSHV vBCL2 to autophagy-vesicle nucleation
N00962  Mutation-inactivated ATXN3 to autophagy-vesicle nucleation
N00993  Mutation-caused aberrant Htt to autophagy-vesicle nucleation
N01302  Early endosomal fusion
N01303  Salmonella SopB to Early endosomal fusion
N01715  Autophagy-vesicle nucleation/elongation/maturation, PI3P synthesis by PI3KC3-C1
N01718  Autophagy-vesicle nucleation/elongation/maturation, PACER-RUBCN-PI3KC3-C2
N01719  Autophagy-vesicle nucleation/elongation/maturation, E3 ubiquitin-ligase Malin
Drug target
Fimepinostat: D11319
Safingol: D05784
Safingol hydrochloride: D05785
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    5289 (PIK3C3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    5289 (PIK3C3)
   04070 Phosphatidylinositol signaling system
    5289 (PIK3C3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    5289 (PIK3C3)
   04140 Autophagy - animal
    5289 (PIK3C3)
   04136 Autophagy - other
    5289 (PIK3C3)
 09160 Human Diseases
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    5289 (PIK3C3)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    5289 (PIK3C3)
   05131 Shigellosis
    5289 (PIK3C3)
   05152 Tuberculosis
    5289 (PIK3C3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5289 (PIK3C3)
   05014 Amyotrophic lateral sclerosis
    5289 (PIK3C3)
   05016 Huntington disease
    5289 (PIK3C3)
   05017 Spinocerebellar ataxia
    5289 (PIK3C3)
   05022 Pathways of neurodegeneration - multiple diseases
    5289 (PIK3C3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    5289 (PIK3C3)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.137  phosphatidylinositol 3-kinase
     5289 (PIK3C3)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Macropinocytosis
   Kinases
    5289 (PIK3C3)
  Rab GTPases and associated proteins
   Rab associated proteins
    5289 (PIK3C3)
 Endosome - Lysosome transport
    5289 (PIK3C3)
 Autophagy
  Autophagosome formation proteins
   PI3K complex
    5289 (PIK3C3)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_C2 HEAT_2
Other DBs
NCBI-GeneID: 5289
NCBI-ProteinID: NP_002638
OMIM: 602609
HGNC: 8974
Ensembl: ENSG00000078142
UniProt: Q8NEB9
Structure
LinkDB
Position
18:41955234..42087830
AA seq 887 aa
MGEAEKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVT
CQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAV
PVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTKTPGRTSSTLSEDQMSRLAKLTK
AHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDG
DESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIV
SYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDV
EDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKK
DSQSSVSENVSNSGINSAEIDSSQIITSPLPSVSSPPPASKTKEVPDGENLEQDLCTFLI
SRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRS
LLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVK
IRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRK
ENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSENGPNGISAE
VMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLN
KEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVK
KVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK
NT seq 2664 nt   +upstreamnt  +downstreamnt
atgggggaagcagagaagtttcactacatctatagttgtgacctggatatcaacgtccag
cttaagataggaagcttggaagggaagagagaacaaaagagttataaagctgtcctggaa
gacccaatgttgaagttctcaggactatatcaagagacatgctctgatctttatgttact
tgtcaagtttttgcagaagggaagcctttggccttgccagtgagaacatcctacaaagca
tttagtacaagatggaactggaatgaatggctgaaactaccagtaaaataccctgacctg
cccaggaatgcccaagtggccctcaccatatgggatgtgtatggtcccggaaaagcagtg
cctgtaggaggaacaacggtttcgctctttggaaaatacggcatgtttcgccaagggatg
catgacttgaaagtctggcctaatgtagaagcagatggatcagaacccacaaaaactcct
ggcagaacaagtagcactctctcagaagatcagatgagccgtcttgccaagctcaccaaa
gctcatcgacaaggacacatggtgaaagtagattggctggatagattgacatttagagaa
atagaaatgataaatgagagtgaaaaacgaagttctaatttcatgtacctgatggttgaa
tttcgatgtgtcaagtgtgatgataaggaatatggtattgtttattatgaaaaggacggt
gatgaatcatctccaattttaacaagttttgaattagtgaaagttcctgacccccagatg
tctatggagaatttagttgagagcaaacaccacaagcttgcccggagtttaagaagtgga
ccttctgaccacgatctgaaacccaatgctgccacgagagatcagttaaatattattgtg
agttatccaccaaccaagcaacttacatatgaagaacaagatcttgtttggaagtttaga
tattatcttacgaatcaagaaaaagccttgacaaaattcttgaaatgtgttaattgggat
ctacctcaagaggccaaacaggccttggaacttctgggaaaatggaagccgatggatgta
gaggactccttggagctgttatcctctcattacaccaacccaactgtgaggcgttatgct
gttgcccggttgcgacaggccgatgatgaggatttgttgatgtacctattacaattggtc
caggctctcaaatatgaaaattttgatgatataaagaatggattggaacctaccaagaag
gatagtcagagttcagtgtcagaaaatgtgtcaaattctggaataaattctgcagaaata
gatagctcccaaattataaccagcccccttccttcagtctcttcacctcctcctgcatca
aaaacaaaagaagttccagatggcgaaaatctggaacaagatctctgtaccttcttgata
tcgagagcctgcaaaaactcaacactggctaattatttatactggtatgtgatagtggaa
tgtgaagatcaagatactcagcagagagatccaaagacccatgagatgtacttgaacgta
atgagaagattcagccaagcattgttgaagggtgataagtctgtcagagttatgcgttct
ttgctggctgcacaacagacatttgtagatcggttggtgcatctaatgaaggcagtacaa
cgcgaaagtggaaatcgtaagaaaaagaatgagagactacaggcattgcttggagataat
gaaaagatgaatttgtcagatgtggaacttatcccgttgcctttagaaccccaagtgaaa
attagaggaataattccggaaacagctacactgtttaaaagtgcccttatgcctgcacag
ttgttttttaagacggaagatggaggcaaatatccagttatatttaagcatggagatgat
ttacgtcaagatcaacttattcttcaaatcatttcactcatggacaagctgttacggaaa
gaaaatctggacttgaaattgacaccttataaggtgttagccaccagtacaaaacatggc
ttcatgcagtttatccagtcagttcctgtggctgaagttcttgatacagagggaagcatt
cagaacttttttagaaaatatgcaccaagtgagaatgggccaaatgggattagtgctgag
gtcatggacacttacgttaaaagctgtgctggatattgcgtgatcacctatatacttgga
gttggagacaggcacctggataaccttttgctaacaaaaacaggcaaactcttccacata
gactttggatatattttgggtcgggatccaaagcctcttcctccaccaatgaagctgaat
aaagaaatggtagaaggaatggggggcacacagagtgagcagtaccaagagttccgtaaa
cagtgttacacggctttcctccacctgcgaaggtattctaatctgattttgaacttgttt
tccttgatggttgatgcaaacattccagatattgcacttgaaccagataaaactgtgaaa
aaggttcaggataaattccgcttagacctgtcggatgaagaggctgtgcattacatgcag
agtctgattgatgagagtgtccatgctctttttgctgcagtggtggaacagattcacaag
tttgcccagtactggagaaaatga

KEGG   Homo sapiens (human): 5295
Entry
5295              CDS       T01001                                 
Symbol
PIK3R1, AGM7, GRB1, IMD36, p85, p85-ALPHA, p85alpha
Name
(RefSeq) phosphoinositide-3-kinase regulatory subunit 1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa01524  Platinum drug resistance
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04024  cAMP signaling pathway
hsa04062  Chemokine signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04068  FoxO signaling pathway
hsa04070  Phosphatidylinositol signaling system
hsa04071  Sphingolipid signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04081  Hormone signaling
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04210  Apoptosis
hsa04211  Longevity regulating pathway
hsa04213  Longevity regulating pathway - multiple species
hsa04218  Cellular senescence
hsa04360  Axon guidance
hsa04370  VEGF signaling pathway
hsa04380  Osteoclast differentiation
hsa04510  Focal adhesion
hsa04517  IgSF CAM signaling
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04611  Platelet activation
hsa04613  Neutrophil extracellular trap formation
hsa04620  Toll-like receptor signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa04668  TNF signaling pathway
hsa04670  Leukocyte transendothelial migration
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
hsa04917  Prolactin signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa04923  Regulation of lipolysis in adipocytes
hsa04926  Relaxin signaling pathway
hsa04929  GnRH secretion
hsa04930  Type II diabetes mellitus
hsa04931  Insulin resistance
hsa04932  Non-alcoholic fatty liver disease
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04935  Growth hormone synthesis, secretion and action
hsa04960  Aldosterone-regulated sodium reabsorption
hsa04973  Carbohydrate digestion and absorption
hsa05010  Alzheimer disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05100  Bacterial invasion of epithelial cells
hsa05131  Shigellosis
hsa05135  Yersinia infection
hsa05142  Chagas disease
hsa05146  Amoebiasis
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05162  Measles
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05171  Coronavirus disease - COVID-19
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05218  Melanoma
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05222  Small cell lung cancer
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05230  Central carbon metabolism in cancer
hsa05231  Choline metabolism in cancer
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05415  Diabetic cardiomyopathy
hsa05417  Lipid and atherosclerosis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06325  Hormone/cytokine signaling
nt06530  PI3K signaling
nt06537  TCR/BCR signaling
  Element
N01165  PDL/PD1-SHP-PI3K signaling pathway
N01656  GF-RTK-PI3K signaling pathway
N01658  GF-RTK-RAS-PI3K signaling pathway
N01695  BCR-BCAP/CD19-PI3K signaling pathway
N01696  ICOSLG/ICOS-PI3K signaling pathway
N01708  INS-AKT signaling pathway
Disease
H00085  Agammaglobulinemias
H01370  SHORT syndrome
H01387  Activated PI3K-delta syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    5295 (PIK3R1)
   04014 Ras signaling pathway
    5295 (PIK3R1)
   04015 Rap1 signaling pathway
    5295 (PIK3R1)
   04370 VEGF signaling pathway
    5295 (PIK3R1)
   04630 JAK-STAT signaling pathway
    5295 (PIK3R1)
   04668 TNF signaling pathway
    5295 (PIK3R1)
   04066 HIF-1 signaling pathway
    5295 (PIK3R1)
   04068 FoxO signaling pathway
    5295 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    5295 (PIK3R1)
   04072 Phospholipase D signaling pathway
    5295 (PIK3R1)
   04071 Sphingolipid signaling pathway
    5295 (PIK3R1)
   04024 cAMP signaling pathway
    5295 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    5295 (PIK3R1)
   04152 AMPK signaling pathway
    5295 (PIK3R1)
   04150 mTOR signaling pathway
    5295 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    5295 (PIK3R1)
   04517 IgSF CAM signaling
    5295 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    5295 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    5295 (PIK3R1)
   04218 Cellular senescence
    5295 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    5295 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    5295 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    5295 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    5295 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    5295 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    5295 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    5295 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    5295 (PIK3R1)
   04660 T cell receptor signaling pathway
    5295 (PIK3R1)
   04662 B cell receptor signaling pathway
    5295 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    5295 (PIK3R1)
   04666 Fc gamma R-mediated phagocytosis
    5295 (PIK3R1)
   04670 Leukocyte transendothelial migration
    5295 (PIK3R1)
   04062 Chemokine signaling pathway
    5295 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    5295 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    5295 (PIK3R1)
   04929 GnRH secretion
    5295 (PIK3R1)
   04915 Estrogen signaling pathway
    5295 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    5295 (PIK3R1)
   04917 Prolactin signaling pathway
    5295 (PIK3R1)
   04926 Relaxin signaling pathway
    5295 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    5295 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    5295 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    5295 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    5295 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    5295 (PIK3R1)
   04722 Neurotrophin signaling pathway
    5295 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    5295 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    5295 (PIK3R1)
   04380 Osteoclast differentiation
    5295 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    5295 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    5295 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    5295 (PIK3R1)
   05206 MicroRNAs in cancer
    5295 (PIK3R1)
   05205 Proteoglycans in cancer
    5295 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    5295 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    5295 (PIK3R1)
   05203 Viral carcinogenesis
    5295 (PIK3R1)
   05230 Central carbon metabolism in cancer
    5295 (PIK3R1)
   05231 Choline metabolism in cancer
    5295 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    5295 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    5295 (PIK3R1)
   05212 Pancreatic cancer
    5295 (PIK3R1)
   05225 Hepatocellular carcinoma
    5295 (PIK3R1)
   05226 Gastric cancer
    5295 (PIK3R1)
   05214 Glioma
    5295 (PIK3R1)
   05221 Acute myeloid leukemia
    5295 (PIK3R1)
   05220 Chronic myeloid leukemia
    5295 (PIK3R1)
   05218 Melanoma
    5295 (PIK3R1)
   05211 Renal cell carcinoma
    5295 (PIK3R1)
   05215 Prostate cancer
    5295 (PIK3R1)
   05213 Endometrial cancer
    5295 (PIK3R1)
   05224 Breast cancer
    5295 (PIK3R1)
   05222 Small cell lung cancer
    5295 (PIK3R1)
   05223 Non-small cell lung cancer
    5295 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    5295 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    5295 (PIK3R1)
   05161 Hepatitis B
    5295 (PIK3R1)
   05160 Hepatitis C
    5295 (PIK3R1)
   05171 Coronavirus disease - COVID-19
    5295 (PIK3R1)
   05164 Influenza A
    5295 (PIK3R1)
   05162 Measles
    5295 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    5295 (PIK3R1)
   05163 Human cytomegalovirus infection
    5295 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    5295 (PIK3R1)
   05169 Epstein-Barr virus infection
    5295 (PIK3R1)
   05165 Human papillomavirus infection
    5295 (PIK3R1)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    5295 (PIK3R1)
   05135 Yersinia infection
    5295 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    5295 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    5295 (PIK3R1)
   05142 Chagas disease
    5295 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5295 (PIK3R1)
   05017 Spinocerebellar ataxia
    5295 (PIK3R1)
   05020 Prion disease
    5295 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    5295 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    5295 (PIK3R1)
   05415 Diabetic cardiomyopathy
    5295 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    5295 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    5295 (PIK3R1)
   04931 Insulin resistance
    5295 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    5295 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    5295 (PIK3R1)
   01524 Platinum drug resistance
    5295 (PIK3R1)
   01522 Endocrine resistance
    5295 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    5295 (PIK3R1)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    5295 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 SH3_1 AAA_13 SH3_2 SH3_9 Laminin_I
Other DBs
NCBI-GeneID: 5295
NCBI-ProteinID: NP_852664
OMIM: 171833
HGNC: 8979
Ensembl: ENSG00000145675
UniProt: P27986 A0A2X0SFG1
Structure
LinkDB
Position
5:68215756..68301821
AA seq 724 aa
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAE
QFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTPSVDLEMIDVH
VLADAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTL
QYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNE
RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIID
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR
NT seq 2175 nt   +upstreamnt  +downstreamnt
atgagtgctgaggggtaccagtacagagcgctgtatgattataaaaaggaaagagaagaa
gatattgacttgcacttgggtgacatattgactgtgaataaagggtccttagtagctctt
ggattcagtgatggacaggaagccaggcctgaagaaattggctggttaaatggctataat
gaaaccacaggggaaaggggggactttccgggaacttacgtagaatatattggaaggaaa
aaaatctcgcctcccacaccaaagccccggccacctcggcctcttcctgttgcaccaggt
tcttcgaaaactgaagcagatgttgaacaacaagctttgactctcccggatcttgcagag
cagtttgcccctcctgacattgccccgcctcttcttatcaagctcgtggaagccattgaa
aagaaaggtctggaatgttcaactctatacagaacacagagctccagcaacctggcagaa
ttacgacagcttcttgattgtgatacaccctccgtggacttggaaatgatcgatgtgcac
gttttggctgacgctttcaaacgctatctcctggacttaccaaatcctgtcattccagca
gccgtttacagtgaaatgatttctttagctccagaagtacaaagctccgaagaatatatt
cagctattgaagaagcttattaggtcgcctagcatacctcatcagtattggcttacgctt
cagtatttgttaaaacatttcttcaagctctctcaaacctccagcaaaaatctgttgaat
gcaagagtactctctgaaattttcagccctatgcttttcagattctcagcagccagctct
gataatactgaaaacctcataaaagttatagaaattttaatctcaactgaatggaatgaa
cgacagcctgcaccagcactgcctcctaaaccaccaaaacctactactgtagccaacaac
ggtatgaataacaatatgtccttacaagatgctgaatggtactggggagatatctcgagg
gaagaagtgaatgaaaaacttcgagatacagcagacgggacctttttggtacgagatgcg
tctactaaaatgcatggtgattatactcttacactaaggaaagggggaaataacaaatta
atcaaaatatttcatcgagatgggaaatatggcttctctgacccattaaccttcagttct
gtggttgaattaataaaccactaccggaatgaatctctagctcagtataatcccaaattg
gatgtgaaattactttatccagtatccaaataccaacaggatcaagttgtcaaagaagat
aatattgaagctgtagggaaaaaattacatgaatataacactcagtttcaagaaaaaagt
cgagaatatgatagattatatgaagaatatacccgcacatcccaggaaatccaaatgaaa
aggacagctattgaagcatttaatgaaaccataaaaatatttgaagaacagtgccagacc
caagagcggtacagcaaagaatacatagaaaagtttaaacgtgaaggcaatgagaaagaa
atacaaaggattatgcataattatgataagttgaagtctcgaatcagtgaaattattgac
agtagaagaagattggaagaagacttgaagaagcaggcagctgagtatcgagaaattgac
aaacgtatgaacagcattaaaccagaccttatccagctgagaaagacgagagaccaatac
ttgatgtggttgactcaaaaaggtgttcggcaaaagaagttgaacgagtggttgggcaat
gaaaacactgaagaccaatattcactggtggaagatgatgaagatttgccccatcatgat
gagaagacatggaatgttggaagcagcaaccgaaacaaagctgaaaacctgttgcgaggg
aagcgagatggcacttttcttgtccgggagagcagtaaacagggctgctatgcctgctct
gtagtggtggacggcgaagtaaagcattgtgtcataaacaaaacagcaactggctatggc
tttgccgagccctataacttgtacagctctctgaaagaactggtgctacattaccaacac
acctcccttgtgcagcacaacgactccctcaatgtcacactagcctacccagtatatgca
cagcagaggcgatga

KEGG   Homo sapiens (human): 5296
Entry
5296              CDS       T01001                                 
Symbol
PIK3R2, MPPH, MPPH1, P85B, p85, p85-BETA, p85beta
Name
(RefSeq) phosphoinositide-3-kinase regulatory subunit 2
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa01524  Platinum drug resistance
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04024  cAMP signaling pathway
hsa04062  Chemokine signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04068  FoxO signaling pathway
hsa04070  Phosphatidylinositol signaling system
hsa04071  Sphingolipid signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04081  Hormone signaling
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04210  Apoptosis
hsa04211  Longevity regulating pathway
hsa04213  Longevity regulating pathway - multiple species
hsa04218  Cellular senescence
hsa04360  Axon guidance
hsa04370  VEGF signaling pathway
hsa04380  Osteoclast differentiation
hsa04510  Focal adhesion
hsa04517  IgSF CAM signaling
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04611  Platelet activation
hsa04613  Neutrophil extracellular trap formation
hsa04620  Toll-like receptor signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa04668  TNF signaling pathway
hsa04670  Leukocyte transendothelial migration
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
hsa04917  Prolactin signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa04923  Regulation of lipolysis in adipocytes
hsa04926  Relaxin signaling pathway
hsa04929  GnRH secretion
hsa04930  Type II diabetes mellitus
hsa04931  Insulin resistance
hsa04932  Non-alcoholic fatty liver disease
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04935  Growth hormone synthesis, secretion and action
hsa04960  Aldosterone-regulated sodium reabsorption
hsa04973  Carbohydrate digestion and absorption
hsa05010  Alzheimer disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05100  Bacterial invasion of epithelial cells
hsa05131  Shigellosis
hsa05135  Yersinia infection
hsa05142  Chagas disease
hsa05146  Amoebiasis
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05162  Measles
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05171  Coronavirus disease - COVID-19
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05218  Melanoma
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05222  Small cell lung cancer
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05230  Central carbon metabolism in cancer
hsa05231  Choline metabolism in cancer
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05415  Diabetic cardiomyopathy
hsa05417  Lipid and atherosclerosis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06325  Hormone/cytokine signaling
nt06530  PI3K signaling
nt06537  TCR/BCR signaling
  Element
N01165  PDL/PD1-SHP-PI3K signaling pathway
N01656  GF-RTK-PI3K signaling pathway
N01658  GF-RTK-RAS-PI3K signaling pathway
N01695  BCR-BCAP/CD19-PI3K signaling pathway
N01696  ICOSLG/ICOS-PI3K signaling pathway
N01708  INS-AKT signaling pathway
Disease
H01885  Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    5296 (PIK3R2)
   04014 Ras signaling pathway
    5296 (PIK3R2)
   04015 Rap1 signaling pathway
    5296 (PIK3R2)
   04370 VEGF signaling pathway
    5296 (PIK3R2)
   04630 JAK-STAT signaling pathway
    5296 (PIK3R2)
   04668 TNF signaling pathway
    5296 (PIK3R2)
   04066 HIF-1 signaling pathway
    5296 (PIK3R2)
   04068 FoxO signaling pathway
    5296 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    5296 (PIK3R2)
   04072 Phospholipase D signaling pathway
    5296 (PIK3R2)
   04071 Sphingolipid signaling pathway
    5296 (PIK3R2)
   04024 cAMP signaling pathway
    5296 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    5296 (PIK3R2)
   04152 AMPK signaling pathway
    5296 (PIK3R2)
   04150 mTOR signaling pathway
    5296 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    5296 (PIK3R2)
   04517 IgSF CAM signaling
    5296 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    5296 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    5296 (PIK3R2)
   04218 Cellular senescence
    5296 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    5296 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    5296 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    5296 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    5296 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    5296 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    5296 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    5296 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    5296 (PIK3R2)
   04660 T cell receptor signaling pathway
    5296 (PIK3R2)
   04662 B cell receptor signaling pathway
    5296 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    5296 (PIK3R2)
   04666 Fc gamma R-mediated phagocytosis
    5296 (PIK3R2)
   04670 Leukocyte transendothelial migration
    5296 (PIK3R2)
   04062 Chemokine signaling pathway
    5296 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    5296 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    5296 (PIK3R2)
   04929 GnRH secretion
    5296 (PIK3R2)
   04915 Estrogen signaling pathway
    5296 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    5296 (PIK3R2)
   04917 Prolactin signaling pathway
    5296 (PIK3R2)
   04926 Relaxin signaling pathway
    5296 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    5296 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    5296 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    5296 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    5296 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    5296 (PIK3R2)
   04722 Neurotrophin signaling pathway
    5296 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    5296 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    5296 (PIK3R2)
   04380 Osteoclast differentiation
    5296 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    5296 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    5296 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    5296 (PIK3R2)
   05206 MicroRNAs in cancer
    5296 (PIK3R2)
   05205 Proteoglycans in cancer
    5296 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    5296 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    5296 (PIK3R2)
   05203 Viral carcinogenesis
    5296 (PIK3R2)
   05230 Central carbon metabolism in cancer
    5296 (PIK3R2)
   05231 Choline metabolism in cancer
    5296 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    5296 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    5296 (PIK3R2)
   05212 Pancreatic cancer
    5296 (PIK3R2)
   05225 Hepatocellular carcinoma
    5296 (PIK3R2)
   05226 Gastric cancer
    5296 (PIK3R2)
   05214 Glioma
    5296 (PIK3R2)
   05221 Acute myeloid leukemia
    5296 (PIK3R2)
   05220 Chronic myeloid leukemia
    5296 (PIK3R2)
   05218 Melanoma
    5296 (PIK3R2)
   05211 Renal cell carcinoma
    5296 (PIK3R2)
   05215 Prostate cancer
    5296 (PIK3R2)
   05213 Endometrial cancer
    5296 (PIK3R2)
   05224 Breast cancer
    5296 (PIK3R2)
   05222 Small cell lung cancer
    5296 (PIK3R2)
   05223 Non-small cell lung cancer
    5296 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    5296 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    5296 (PIK3R2)
   05161 Hepatitis B
    5296 (PIK3R2)
   05160 Hepatitis C
    5296 (PIK3R2)
   05171 Coronavirus disease - COVID-19
    5296 (PIK3R2)
   05164 Influenza A
    5296 (PIK3R2)
   05162 Measles
    5296 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    5296 (PIK3R2)
   05163 Human cytomegalovirus infection
    5296 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    5296 (PIK3R2)
   05169 Epstein-Barr virus infection
    5296 (PIK3R2)
   05165 Human papillomavirus infection
    5296 (PIK3R2)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    5296 (PIK3R2)
   05135 Yersinia infection
    5296 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    5296 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    5296 (PIK3R2)
   05142 Chagas disease
    5296 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5296 (PIK3R2)
   05017 Spinocerebellar ataxia
    5296 (PIK3R2)
   05020 Prion disease
    5296 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    5296 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    5296 (PIK3R2)
   05415 Diabetic cardiomyopathy
    5296 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    5296 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    5296 (PIK3R2)
   04931 Insulin resistance
    5296 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    5296 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    5296 (PIK3R2)
   01524 Platinum drug resistance
    5296 (PIK3R2)
   01522 Endocrine resistance
    5296 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    5296 (PIK3R2)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    5296 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH2_1 Ribosomal_L22e SH3_9
Other DBs
NCBI-GeneID: 5296
NCBI-ProteinID: NP_005018
OMIM: 603157
HGNC: 8980
Ensembl: ENSG00000105647
UniProt: O00459
Structure
LinkDB
Position
19:18153163..18170532
AA seq 728 aa
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSP
PDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLA
LPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALG
PAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPP
ALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSK
IQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTR
LLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTA
IEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRT
KLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNE
TEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVV
VDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPG
PGPPPAAR
NT seq 2187 nt   +upstreamnt  +downstreamnt
atggcgggccctgagggcttccagtaccgcgctctgtacccgttccgccgggagcggccg
gaggacctggagctgctgcccggcgacgtgctggtagtgagccgggcggccttgcaggcg
ctgggcgtggccgagggtggcgagcgctgcccacagagcgtgggctggatgcccggcctc
aacgagcgcacacggcagcgaggtgacttccctggcacctatgtggagttcctggggccc
gtggccctggcccggcccggccctcgcccacggggcccccgcccactgcccgccaggccc
cgtgatggggcccctgagccaggcctcacactccccgacttgcccgagcagttctcccca
cctgatgtggctccccctcttctggtgaagcttgtggaggccattgaaaggacagggctg
gacagcgaatctcactaccgcccggagctgcccgcaccgcgtacagactggtccctgagc
gacgtggatcagtgggacacggcagccctggctgacggcattaagagcttcctgctggca
ctgcccgcgccgctcgtgacccccgaggcctcggccgaggcgcgccgggccctgcgggag
gccgcggggcccgtggggccggcgctggagccaccgacgctgccgctgcaccgcgcgctc
acgctgcgcttcctgctccagcacctgggccgcgtggccagccgcgccccggccctgggt
cccgcggtccgggccctgggcgccacctttgggccgctgctgctgcgcgcgccgccgccg
ccgtcctcgccgccgccagggggcgctcccgacgggagtgagcccagccctgacttcccg
gcgctgctggtggagaagctgcttcaggaacacttggaagagcaggaggttgcgccccca
gcgctgccgcctaaaccccccaaggcaaagccggcctccacagtcctggccaatggaggg
agcccaccctccctgcaggatgctgagtggtactggggggacatttcaagggaggaggtg
aacgagaaactccgggacactcccgatggcaccttcctagtccgagatgcttctagcaag
atccagggcgagtacacgctgaccctcaggaaaggcgggaacaataagctgatcaaggtc
ttccaccgagatgggcactatggcttctcagagccactcaccttctgctccgttgtggac
ctcatcaatcactaccgccacgagtctctggcccagtacaatgccaagctggacacacgg
ctcctctaccctgtgtccaaataccagcaggaccagattgtcaaggaggacagcgtggag
gcagtgggcgcccagcttaaggtctatcaccagcagtaccaggacaagagccgcgagtat
gaccagctttatgaagagtacacacggacctcccaggagctgcagatgaagcgtactgca
attgaggccttcaatgagactatcaagatctttgaagagcagggccagactcaagagaaa
tgcagcaaggaatacctggagcgcttccggcgtgagggcaacgagaaagagatgcaaagg
atcctgctgaactccgagcggctcaagtcccgcattgccgagatccatgagagccgcacg
aagctggagcagcagctgcgggcccaggcctcggacaacagagagatcgacaagcgcatg
aacagcctcaagccggacctcatgcagctgcgcaagatccgagaccagtacctcgtgtgg
ctcacccagaaaggcgcccggcagaagaaaatcaacgagtggctggggattaaaaatgag
actgaggaccagtacgcactcatggaggacgaggacgatctcccgcaccacgaggaacgc
acttggtacgtgggcaagatcaaccgcacgcaggcagaggagatgctgagtggcaagcgg
gatggcaccttcctcatccgcgagagcagccagcggggctgctacgcctgctccgtggta
gtggacggcgacaccaagcactgcgtcatctaccgcacggccaccggcttcggcttcgcg
gagccctacaacctgtacgggtcgctgaaggagctggtgctgcactaccagcacgcctcg
ctggtgcagcacaacgacgcgctcaccgtcaccctggcgcacccagtgcgcgccccgggc
cccggcccgccgcctgccgcccgctga

KEGG   Homo sapiens (human): 8503
Entry
8503              CDS       T01001                                 
Symbol
PIK3R3, p55, p55-GAMMA, p55PIK
Name
(RefSeq) phosphoinositide-3-kinase regulatory subunit 3
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa01524  Platinum drug resistance
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04024  cAMP signaling pathway
hsa04062  Chemokine signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04068  FoxO signaling pathway
hsa04070  Phosphatidylinositol signaling system
hsa04071  Sphingolipid signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04081  Hormone signaling
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04210  Apoptosis
hsa04211  Longevity regulating pathway
hsa04213  Longevity regulating pathway - multiple species
hsa04218  Cellular senescence
hsa04360  Axon guidance
hsa04370  VEGF signaling pathway
hsa04380  Osteoclast differentiation
hsa04510  Focal adhesion
hsa04517  IgSF CAM signaling
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04611  Platelet activation
hsa04613  Neutrophil extracellular trap formation
hsa04620  Toll-like receptor signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa04668  TNF signaling pathway
hsa04670  Leukocyte transendothelial migration
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
hsa04917  Prolactin signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa04923  Regulation of lipolysis in adipocytes
hsa04926  Relaxin signaling pathway
hsa04929  GnRH secretion
hsa04930  Type II diabetes mellitus
hsa04931  Insulin resistance
hsa04932  Non-alcoholic fatty liver disease
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04935  Growth hormone synthesis, secretion and action
hsa04960  Aldosterone-regulated sodium reabsorption
hsa04973  Carbohydrate digestion and absorption
hsa05010  Alzheimer disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05100  Bacterial invasion of epithelial cells
hsa05131  Shigellosis
hsa05135  Yersinia infection
hsa05142  Chagas disease
hsa05146  Amoebiasis
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05162  Measles
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05171  Coronavirus disease - COVID-19
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05218  Melanoma
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05222  Small cell lung cancer
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05230  Central carbon metabolism in cancer
hsa05231  Choline metabolism in cancer
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05415  Diabetic cardiomyopathy
hsa05417  Lipid and atherosclerosis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06325  Hormone/cytokine signaling
nt06530  PI3K signaling
nt06537  TCR/BCR signaling
  Element
N01165  PDL/PD1-SHP-PI3K signaling pathway
N01656  GF-RTK-PI3K signaling pathway
N01658  GF-RTK-RAS-PI3K signaling pathway
N01695  BCR-BCAP/CD19-PI3K signaling pathway
N01696  ICOSLG/ICOS-PI3K signaling pathway
N01708  INS-AKT signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    8503 (PIK3R3)
   04014 Ras signaling pathway
    8503 (PIK3R3)
   04015 Rap1 signaling pathway
    8503 (PIK3R3)
   04370 VEGF signaling pathway
    8503 (PIK3R3)
   04630 JAK-STAT signaling pathway
    8503 (PIK3R3)
   04668 TNF signaling pathway
    8503 (PIK3R3)
   04066 HIF-1 signaling pathway
    8503 (PIK3R3)
   04068 FoxO signaling pathway
    8503 (PIK3R3)
   04070 Phosphatidylinositol signaling system
    8503 (PIK3R3)
   04072 Phospholipase D signaling pathway
    8503 (PIK3R3)
   04071 Sphingolipid signaling pathway
    8503 (PIK3R3)
   04024 cAMP signaling pathway
    8503 (PIK3R3)
   04151 PI3K-Akt signaling pathway
    8503 (PIK3R3)
   04152 AMPK signaling pathway
    8503 (PIK3R3)
   04150 mTOR signaling pathway
    8503 (PIK3R3)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    8503 (PIK3R3)
   04517 IgSF CAM signaling
    8503 (PIK3R3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    8503 (PIK3R3)
  09143 Cell growth and death
   04210 Apoptosis
    8503 (PIK3R3)
   04218 Cellular senescence
    8503 (PIK3R3)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    8503 (PIK3R3)
   04550 Signaling pathways regulating pluripotency of stem cells
    8503 (PIK3R3)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    8503 (PIK3R3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    8503 (PIK3R3)
   04613 Neutrophil extracellular trap formation
    8503 (PIK3R3)
   04620 Toll-like receptor signaling pathway
    8503 (PIK3R3)
   04625 C-type lectin receptor signaling pathway
    8503 (PIK3R3)
   04650 Natural killer cell mediated cytotoxicity
    8503 (PIK3R3)
   04660 T cell receptor signaling pathway
    8503 (PIK3R3)
   04662 B cell receptor signaling pathway
    8503 (PIK3R3)
   04664 Fc epsilon RI signaling pathway
    8503 (PIK3R3)
   04666 Fc gamma R-mediated phagocytosis
    8503 (PIK3R3)
   04670 Leukocyte transendothelial migration
    8503 (PIK3R3)
   04062 Chemokine signaling pathway
    8503 (PIK3R3)
  09152 Endocrine system
   04910 Insulin signaling pathway
    8503 (PIK3R3)
   04923 Regulation of lipolysis in adipocytes
    8503 (PIK3R3)
   04929 GnRH secretion
    8503 (PIK3R3)
   04915 Estrogen signaling pathway
    8503 (PIK3R3)
   04914 Progesterone-mediated oocyte maturation
    8503 (PIK3R3)
   04917 Prolactin signaling pathway
    8503 (PIK3R3)
   04926 Relaxin signaling pathway
    8503 (PIK3R3)
   04935 Growth hormone synthesis, secretion and action
    8503 (PIK3R3)
   04919 Thyroid hormone signaling pathway
    8503 (PIK3R3)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    8503 (PIK3R3)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    8503 (PIK3R3)
  09156 Nervous system
   04725 Cholinergic synapse
    8503 (PIK3R3)
   04722 Neurotrophin signaling pathway
    8503 (PIK3R3)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    8503 (PIK3R3)
  09158 Development and regeneration
   04360 Axon guidance
    8503 (PIK3R3)
   04380 Osteoclast differentiation
    8503 (PIK3R3)
  09149 Aging
   04211 Longevity regulating pathway
    8503 (PIK3R3)
   04213 Longevity regulating pathway - multiple species
    8503 (PIK3R3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    8503 (PIK3R3)
   05206 MicroRNAs in cancer
    8503 (PIK3R3)
   05205 Proteoglycans in cancer
    8503 (PIK3R3)
   05207 Chemical carcinogenesis - receptor activation
    8503 (PIK3R3)
   05208 Chemical carcinogenesis - reactive oxygen species
    8503 (PIK3R3)
   05203 Viral carcinogenesis
    8503 (PIK3R3)
   05230 Central carbon metabolism in cancer
    8503 (PIK3R3)
   05231 Choline metabolism in cancer
    8503 (PIK3R3)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    8503 (PIK3R3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    8503 (PIK3R3)
   05212 Pancreatic cancer
    8503 (PIK3R3)
   05225 Hepatocellular carcinoma
    8503 (PIK3R3)
   05226 Gastric cancer
    8503 (PIK3R3)
   05214 Glioma
    8503 (PIK3R3)
   05221 Acute myeloid leukemia
    8503 (PIK3R3)
   05220 Chronic myeloid leukemia
    8503 (PIK3R3)
   05218 Melanoma
    8503 (PIK3R3)
   05211 Renal cell carcinoma
    8503 (PIK3R3)
   05215 Prostate cancer
    8503 (PIK3R3)
   05213 Endometrial cancer
    8503 (PIK3R3)
   05224 Breast cancer
    8503 (PIK3R3)
   05222 Small cell lung cancer
    8503 (PIK3R3)
   05223 Non-small cell lung cancer
    8503 (PIK3R3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    8503 (PIK3R3)
   05170 Human immunodeficiency virus 1 infection
    8503 (PIK3R3)
   05161 Hepatitis B
    8503 (PIK3R3)
   05160 Hepatitis C
    8503 (PIK3R3)
   05171 Coronavirus disease - COVID-19
    8503 (PIK3R3)
   05164 Influenza A
    8503 (PIK3R3)
   05162 Measles
    8503 (PIK3R3)
   05168 Herpes simplex virus 1 infection
    8503 (PIK3R3)
   05163 Human cytomegalovirus infection
    8503 (PIK3R3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    8503 (PIK3R3)
   05169 Epstein-Barr virus infection
    8503 (PIK3R3)
   05165 Human papillomavirus infection
    8503 (PIK3R3)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    8503 (PIK3R3)
   05135 Yersinia infection
    8503 (PIK3R3)
   05100 Bacterial invasion of epithelial cells
    8503 (PIK3R3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    8503 (PIK3R3)
   05142 Chagas disease
    8503 (PIK3R3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    8503 (PIK3R3)
   05017 Spinocerebellar ataxia
    8503 (PIK3R3)
   05020 Prion disease
    8503 (PIK3R3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    8503 (PIK3R3)
   05418 Fluid shear stress and atherosclerosis
    8503 (PIK3R3)
   05415 Diabetic cardiomyopathy
    8503 (PIK3R3)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    8503 (PIK3R3)
   04932 Non-alcoholic fatty liver disease
    8503 (PIK3R3)
   04931 Insulin resistance
    8503 (PIK3R3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    8503 (PIK3R3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    8503 (PIK3R3)
   01524 Platinum drug resistance
    8503 (PIK3R3)
   01522 Endocrine resistance
    8503 (PIK3R3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    8503 (PIK3R3)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    8503 (PIK3R3)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 SH2_1 Transcrip_act Exonuc_VII_L Bap31_Bap29_C
Other DBs
NCBI-GeneID: 8503
NCBI-ProteinID: NP_001107644
OMIM: 606076
HGNC: 8981
Ensembl: ENSG00000117461
UniProt: Q92569 Q8N381
LinkDB
Position
1:complement(46040140..46174901)
AA seq 461 aa
MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSL
QDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG
KYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKK
LQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEY
IERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKNQALDNREIDKKMNSIKP
DLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFV
EDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYN
LYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR
NT seq 1386 nt   +upstreamnt  +downstreamnt
atgtacaatacggtgtggagtatggaccgcgatgacgcagactggagggaggtgatgatg
ccctattcgacagaactgatattttatattgaaatggatcctccagctcttccaccaaag
ccacctaagccaatgacttcagcagttccaaatggaatgaaggacagttctgtttctctt
caggatgcagaatggtactggggggatatttcaagggaggaggtaaatgacaaattgcgg
gatatgccagatgggaccttcttggtccgagatgcctcaacaaaaatgcagggagattat
actttgactttgcggaagggaggcaataataagttaataaagatctatcaccgggatggt
aaatatggcttttctgatcctctgacatttaattccgtggtggagctcattaaccactat
caccatgaatctcttgctcagtacaatcccaaacttgatgtgaagctgatgtacccagtg
tccagataccaacaggatcagttggtaaaagaagataatattgatgcagtaggtaaaaaa
ctgcaagaataccactctcagtatcaggagaagagtaaagagtatgataggctgtatgaa
gaatatactagaacatcccaggaaatacagatgaagaggactgcaatagaagcttttaat
gaaacaattaaaatatttgaagagcagtgtcacacacaagaacaacatagcaaagaatat
attgagcgatttcgcagagaggggaatgaaaaggagattgaacgaattatgatgaattat
gataaattgaaatcacgtctgggtgagattcatgatagcaaaatgcgtctagagcaggat
ttgaagaatcaagctttggacaaccgagaaatagataaaaaaatgaatagcatcaaacct
gacctgatccagctgcgaaagatccgagatcaacaccttgtatggctcaatcacaaagga
gtgagacagaaacgcctgaatgtctggctgggaattaagaatgaggatgctgatgagaac
tattttatcaatgaggaagatgaaaacctgccccattatgatgagaaaacctggtttgtt
gaggatatcaatcgagtacaagcagaggacttgctttatgggaaacctgatggtgcattc
ttaattcgtgagagtagcaagaaaggatgctatgcttgctctgtggtggccgatggggaa
gtgaagcactgtgtgatctacagcactgctcggggctatggctttgcagagccctacaac
ctgtacagctctctgaaggagctagtgctccattaccagcagacatccttggttcagcac
aacgactccctcaacgtcaggcttgcctaccctgttcatgcacagatgccctcgctttgc
agataa

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