KEGG T01001: 11255

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    11255 (HRH3)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    11255 (HRH3)
G protein-coupled receptors [BR:hsa04030]
Rhodopsin family
  Biogenic amine
   Histamine
    11255 (HRH3)

SSDB

Motif

Pfam:

7tm_1 7TM_GPCR_Srsx 7tm_4 DUF3367 7TM_GPCR_Srx DUF621

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

Q9Y5N1(Tclin)

UniProt:

Q9Y5N1

LinkDB

Position

20q13.33

AA seq 445 aa
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK

NT seq 1338 nt +upstreamnt +downstreamnt
atggagcgcgcgccgcccgacgggccgctgaacgcttcgggggcgctggcgggcgaggcg
gcggcggcgggcggggcgcgcggcttctcggcagcctggaccgcggtgctggccgcgctc
atggcgctgctcatcgtggccacggtgctgggcaacgcgctggtcatgctcgccttcgtg
gccgactcgagcctccgcacccagaacaacttcttcctgctcaacctcgccatctccgac
ttcctcgtcggcgccttctgcatcccactgtatgtaccctacgtgctgacaggccgctgg
accttcggccggggcctctgcaagctgtggctggtagtggactacctgctgtgcacctcc
tctgccttcaacatcgtgctcatcagctacgaccgcttcctgtcggtcacccgagcggtc
tcataccgggcccagcagggtgacacgcggcgggcagtgcggaagatgctgctggtgtgg
gtgctggccttcctgctgtacggaccagccatcctgagctgggagtacctgtccgggggc
agctccatccccgagggccactgctatgccgagttcttctacaactggtacttcctcatc
acggcttccaccctggagttctttacgcccttcctcagcgtcaccttctttaacctcagc
atctacctgaacatccagaggcgcacccgcctccggctggatggggctcgagaggcagcc
ggccccgagccccctcccgaggcccagccctcaccacccccaccgcctggctgctggggc
tgctggcagaaggggcacggggaggccatgccgctgcacaggtatggggtgggtgaggcg
gccgtaggcgctgaggccggggaggcgaccctcgggggtggcggtgggggcggctccgtg
gcttcacccacctccagctccggcagctcctcgaggggcactgagaggccgcgctcactc
aagaggggctccaagccgtcggcgtcctcggcctcgctggagaagcgcatgaagatggtg
tcccagagcttcacccagcgctttcggctgtctcgggacaggaaagtggccaagtcgctg
gccgtcatcgtgagcatctttgggctctgctgggccccatacacgctgctgatgatcatc
cgggccgcctgccatggccactgcgtccctgactactggtacgaaacctccttctggctc
ctgtgggccaactcggctgtcaaccctgtcctctaccctctgtgccaccacagcttccgc
cgggccttcaccaagctgctctgcccccagaagctcaaaatccagccccacagctccctg
gagcactgctggaagtga

Homo sapiens (human): 3269

Entry

3269 CDS T01001

Gene name

HRH1, H1-R, H1R, HH1R, hisH1

Definition

(RefSeq) histamine receptor H1

K04149

histamine receptor H1

Organism

hsa Homo sapiens (human)

Pathway

hsa04020

Calcium signaling pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04750

Inflammatory mediator regulation of TRP channels

Drug target

Acrivastine:

D02760

Alcaftadine:

D06552<US>

Alimemazine (DG01101):

D02245<JP> D07125

Antazoline (DG01037):

D02950 D07458 D07459

Astemizole:

D00234

Azatadine (DG01112):

D00662 D07482

Azelastine (DG01036):

D00659<JP/US> D07483

Bamipine (DG00388):

D07197 D07492 D07493

Barmastine:

D03056

Bepotastine (DG01327):

D01654<JP/US> D09705

Betahistine (DG01004):

D01592<JP> D03102 D07522

Bilastine:

D09570<JP>

Bisulepin:

D07532

Bisulepin hydrochloride:

D07533

Broizine:

D09838

Bromazine:

D03166

Brompheniramine (DG01097):

D00663 D07543

Buclizine (DG01104):

D02089 D07547

Carbinoxamine (DG01095):

D01336<US> D07617 D09808

Cetirizine (DG01107):

D00664<JP/US> D07662

Chloropyramine (DG00384):

D07195 D07679

Chlorphenamine (DG01099):

D00665<JP> D03475 D07398

Chlorphenoxamine (DG00391):

D07198 D07684

Chlorpromazine (DG00867):

D00270 D00789<JP/US> D03274 D04034<JP> D09819

Cidoxepin hydrochloride:

D03491

Cinnarizine (DG01005):

D01295 D07734

Clemastine (DG00387):

D00666<JP/US> D03535

Closiramine aceturate:

D03568

Cycliramine maleate:

D03620

Cyclizine (DG01105):

D02090 D03621 D03622

Cyproheptadine (DG01109):

D02234<JP/US> D07765

Deptropine (DG01114):

D07404 D07790

Desloratadine:

D03693<JP/US>

Dexbrompheniramine:

D03704

Dexchlorpheniramine (DG01098):

D00668<JP/US> D07803

Difeterol (DG02077):

D01701 D09747 D09748

Dimenhydrinate:

D00520<JP/US>

Dimetindene (DG00386):

D01343 D07853

Dimetotiazine (DG00843):

D01902<JP> D07854

Dioxopromethazine hydrochloride:

D07860

Diphenhydramine (DG00390):

D00300<JP> D00669<JP/US> D02419 D03285 D03360<JP> D03854

Diphenylimidazole:

D02067

Diphenylpyraline (DG01094):

D01172 D01627 D07862

Dorastine hydrochloride:

D03893

Doxepin (DG00937):

D00814<US> D07875

Doxylamine (DG01096):

D02327 D07878

Ebastine:

D01478<JP>

Efletirizine dihydrochloride:

D03963

Embramine:

D07889

Emedastine (DG01144):

D02249<JP> D07890

Epinastine (DG01116):

D01713<JP/US> D07900

Esmirtazapine maleate:

D04055

Fexofenadine (DG01117):

D00671<JP/US> D07958

Histamine:

D08040<US>

Histamine phosphate:

D04445<US>

Histapyrrodine:

D07400

Homochlorcyclizine (DG01328):

D01460<JP> D08041

Hydroxyzine (DG00912):

D00672<JP/US> D01096<JP/US> D08054

Icotidine:

D04494

Isothipendyl (DG00389):

D01143 D08091

Ketotifen (DG01115):

D01332<JP> D08105

Levocabastine (DG01035):

D01717<JP> D08117

Levocetirizine (DG01108):

D07402 D08118<JP/US>

Loratadine:

D00364<JP>

Mebhydrolin (DG01113):

D01786 D08161

Meclozine (DG01106):

D01317<US> D08163

Mepyramine (DG00382):

D05660 D08183

Mequitazine:

D01324<JP>

Methdilazine (DG01103):

D04979 D04980

Mizolastine:

D01117

Noberastine:

D05196

Olanzapine (DG00898):

D00454<JP/US> D06623<US>

Olopatadine (DG01039):

D01192<JP/US> D08293

Opipramol (DG00930):

D01477 D08297

Orphenadrine (DG01252):

D08305

Orphenadrine (chloride):

D02599

Orphenadrine (citrate):

D00774<US>

Oxomemazine:

D07401

Phenindamine (DG01110):

D02148 D08353

Pheniramine (DG01100):

D01174 D08355

Phenyltoloxamine citrate:

D08967

Pimethixene:

D07406

Promethazine (DG00385):

D00480<JP/US> D00494 D01242 D03290<JP> D08432 D08768<JP>

Pyroxamine maleate:

D05664

Pyrrobutamine:

D07403

Quifenadine:

D10230

Rocastine hydrochloride:

D05742

Rotoxamine:

D05769

Rupatadine (DG01118):

D07407 D08497<JP>

Sequifenadine:

D10510

Tazifylline hydrochloride:

Tecastemizole:

Temelastine:

Terfenadine:

Tesmilifene hydrochloride:

D06084

Thenalidine:

D07194

Thonzylamine (DG00381):

D01801 D08587

Tolpropamine:

D07196

Tripelennamine (DG00383):

D02091 D06246 D08645

Triprolidine (DG01111):

D01782 D08648

Zolamine hydrochloride:

D06376

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    3269 (HRH1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    3269 (HRH1)
09150 Organismal Systems
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    3269 (HRH1)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    3269 (HRH1)
G protein-coupled receptors [BR:hsa04030]
Rhodopsin family
  Biogenic amine
   Histamine
    3269 (HRH1)

SSDB

Motif

Pfam:

7tm_1 7TM_GPCR_Srsx 7tm_4 DUF1601

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P35367(Tclin)

UniProt:

P35367

LinkDB

Position

3p25.3

AA seq 487 aa
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS

NT seq 1464 nt +upstreamnt +downstreamnt
atgagcctccccaattcctcctgcctcttagaagacaagatgtgtgagggcaacaagacc
actatggccagcccccagctgatgcccctggtggtggtcctgagcactatctgcttggtc
acagtagggctcaacctgctggtgctgtatgccgtacggagtgagcggaagctccacact
gtggggaacctgtacatcgtcagcctctcggtggcggacttgatcgtgggtgccgtcgtc
atgcctatgaacatcctctacctgctcatgtccaagtggtcactgggccgtcctctctgc
ctcttttggctttccatggactatgtggccagcacagcgtccattttcagtgtcttcatc
ctgtgcattgatcgctaccgctctgtccagcagcccctcaggtaccttaagtatcgtacc
aagacccgagcctcggccaccattctgggggcctggtttctctcttttctgtgggttatt
cccattctaggctggaatcacttcatgcagcagacctcggtgcgccgagaggacaagtgt
gagacagacttctatgatgtcacctggttcaaggtcatgactgccatcatcaacttctac
ctgcccaccttgctcatgctctggttctatgccaagatctacaaggccgtacgacaacac
tgccagcaccgggagctcatcaataggtccctcccttccttctcagaaattaagctgagg
ccagagaaccccaagggggatgccaagaaaccagggaaggagtctccctgggaggttctg
aaaaggaagccaaaagatgctggtggtggatctgtcttgaagtcaccatcccaaaccccc
aaggagatgaaatccccagttgtcttcagccaagaggatgatagagaagtagacaaactc
tactgctttccacttgatattgtgcacatgcaggctgcggcagaggggagtagcagggac
tatgtagccgtcaaccggagccatggccagctcaagacagatgagcagggcctgaacaca
catggggccagcgagatatcagaggatcagatgttaggtgatagccaatccttctctcga
acggactcagataccaccacagagacagcaccaggcaaaggcaaattgaggagtgggtct
aacacaggcctggattacatcaagtttacttggaagaggctccgctcgcattcaagacag
tatgtatctgggttgcacatgaaccgcgaaaggaaggccgccaaacagttgggttttatc
atggcagccttcatcctctgctggatcccttatttcatcttcttcatggtcattgccttc
tgcaagaactgttgcaatgaacatttgcacatgttcaccatctggctgggctacatcaac
tccacactgaaccccctcatctaccccttgtgcaatgagaacttcaagaagacattcaag
agaattctgcatattcgctcctaa

Homo sapiens (human): 3274

Entry

3274 CDS T01001

Gene name

HRH2, H2R, HH2R

Definition

(RefSeq) histamine receptor H2

K04150

histamine receptor H2

Organism

hsa Homo sapiens (human)

Pathway

hsa04020

Calcium signaling pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04971

Gastric acid secretion

Drug target

Betazole:

D01187

Cimetidine (DG00017):

D00295<JP/US> D03503<US>

Dalcotidine:

D01698

Donetidine:

D03889

Etintidine hydrochloride:

D04098

Famotidine:

D00318<JP/US>

Histamine:

D08040<US>

Histamine phosphate:

D04445<US>

Icotidine:

D04494

Impromidine hydrochloride:

D04517

Lafutidine:

D01131<JP>

Lavoltidine succinate:

D04680

Lupitidine hydrochloride:

D04794

Methantheline (DG00036):

D00721

Metiamide:

D05004

Niperotidine:

D07072

Nizatidine:

D00440<JP/US>

Osutidine:

D01193

Oxmetidine (DG01225):

D05306 D05307

Pibutidine hydrochloride:

D01861

Ranitidine (DG00018):

D00422 D00673<JP/US>

Ranitidine bismuth citrate:

D05699

Roxatidine (DG00019):

D01467<JP> D08494 D08495

Sufotidine:

D05939

Tiotidine:

D06157

Zaltidine hydrochloride:

D06355

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    3274 (HRH2)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    3274 (HRH2)
09150 Organismal Systems
  09154 Digestive system
   04971 Gastric acid secretion
    3274 (HRH2)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    3274 (HRH2)
G protein-coupled receptors [BR:hsa04030]
Rhodopsin family
  Biogenic amine
   Histamine
    3274 (HRH2)

SSDB

Motif

Pfam:

7tm_1 7TM_GPCR_Srsx 7tm_4

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P25021(Tclin)

UniProt:

P25021

LinkDB

Position

5q35.2

AA seq 397 aa
MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL
AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE
VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM
GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ
QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDRP
WLCLPECWSVELTHSFIHLFIHSFANIHPIPTTCQEL

NT seq 1194 nt +upstreamnt +downstreamnt
atggcacccaatggcacagcctcttccttttgcctggactctaccgcatgcaagatcacc
atcaccgtggtccttgcggtcctcatcctcatcaccgttgctggcaatgtggtcgtctgt
ctggccgtgggcttgaaccgccggctccgcaacctgaccaattgtttcatcgtgtccttg
gctatcactgacctgctcctcggcctcctggtgctgcccttctctgccatctaccagctg
tcctgcaagtggagctttggcaaggtcttctgcaatatctacaccagcctggatgtgatg
ctctgcacagcctccattcttaacctcttcatgatcagcctcgaccggtactgcgctgtc
atggacccactgcggtaccctgtgctggtcaccccagttcgggtcgccatctctctggtc
ttaatttgggtcatctccattaccctgtcctttctgtctatccacctggggtggaacagc
aggaacgagaccagcaagggcaatcataccacctctaagtgcaaagtccaggtcaatgaa
gtgtacgggctggtggatgggctggtcaccttctacctcccgctactgatcatgtgcatc
acctactaccgcatcttcaaggtcgcccgggatcaggccaagaggatcaatcacattagc
tcctggaaggcagccaccatcagggagcacaaagccacagtgacactggccgccgtcatg
ggggccttcatcatctgctggtttccctacttcaccgcgtttgtgtaccgtgggctgaga
ggggatgatgccatcaatgaggtgttagaagccatcgttctgtggctgggctatgccaac
tcagccctgaaccccatcctgtatgctgcgctgaacagagacttccgcaccgggtaccaa
cagctcttctgctgcaggctggccaaccgcaactcccacaaaacttctctgaggtccaac
gcctctcagctgtccaggacccaaagccgagaacccaggcaacaggaagagaaacccctg
aagctccaggtgtggagtgggacagaagtcacggccccccagggagccacagacagacca
tggctttgccttccagaatgctggtctgtggaactgacccattcattcattcatttgttc
attcattcatttgcaaacattcatccaattcccaccacatgccaggaattatga

Homo sapiens (human): 59340

Entry

59340 CDS T01001

Gene name

HRH4, AXOR35, BG26, GPCR105, GPRv53, H4, H4R, HH4R

Definition

(RefSeq) histamine receptor H4

K04152

histamine receptor H4

Organism

hsa Homo sapiens (human)

Pathway

hsa04080

Neuroactive ligand-receptor interaction

Drug target

Adriforant:

D11819

Histamine:

D08040<US>

Toreforant (DG01866):

D10735 D10736

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    59340 (HRH4)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    59340 (HRH4)
G protein-coupled receptors [BR:hsa04030]
Rhodopsin family
  Biogenic amine
   Histamine
    59340 (HRH4)

SSDB

Motif

Pfam:

7tm_1 7TM_GPCR_Srsx 7tm_4 MPS-4

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

Q9H3N8(Tchem)

UniProt:

Q9H3N8

LinkDB

Position

18q11.2

AA seq 390 aa
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS

NT seq 1173 nt +upstreamnt +downstreamnt
atgccagatactaatagcacaatcaatttatcactaagcactcgtgttactttagcattt
tttatgtccttagtagcttttgctataatgctaggaaatgctttggtcattttagctttt
gtggtggacaaaaaccttagacatcgaagtagttatttttttcttaacttggccatctct
gacttctttgtgggtgtgatctccattcctttgtacatccctcacacgctgttcgaatgg
gattttggaaaggaaatctgtgtattttggctcactactgactatctgttatgtacagca
tctgtatataacattgtcctcatcagctatgatcgatacctgtcagtctcaaatgctgtg
tcttatagaactcaacatactggggtcttgaagattgttactctgatggtggccgtttgg
gtgctggccttcttagtgaatgggccaatgattctagtttcagagtcttggaaggatgaa
ggtagtgaatgtgaacctggatttttttcggaatggtacatccttgccatcacatcattc
ttggaattcgtgatcccagtcatcttagtcgcttatttcaacatgaatatttattggagc
ctgtggaagcgtgatcatctcagtaggtgccaaagccatcctggactgactgctgtctct
tccaacatctgtggacactcattcagaggtagactatcttcaaggagatctctttctgca
tcgacagaagttcctgcatcctttcattcagagagacagaggagaaagagtagtctcatg
ttttcctcaagaaccaagatgaatagcaatacaattgcttccaaaatgggttccttctcc
caatcagattctgtagctcttcaccaaagggaacatgttgaactgcttagagccaggaga
ttagccaagtcactggccattctcttaggggtttttgctgtttgctgggctccatattct
ctgttcacaattgtcctttcattttattcctcagcaacaggtcctaaatcagtttggtat
agaattgcattttggcttcagtggttcaattcctttgtcaatcctcttttgtatccattg
tgtcacaagcgctttcaaaaggctttcttgaaaatattttgtataaaaaagcaacctcta
ccatcacaacacagtcggtcagtatcttcttaa

DBGET integrated database retrieval system