Homo sapiens (human): 11255 Help Entry 11255             CDS       T01001                                  Symbol HRH3, GPCR97, HH3R Name (RefSeq) histamine receptor H3   KO K04151   histamine receptor H3 Organism hsa  Homo sapiens (human) Pathway hsa04080   Neuroactive ligand-receptor interaction Drug target Bavisant (DG02043):  D09870 D09871 Betahistine (DG01004):  D01592<JP> D03102 D07522 Cipralisant maleate:  D03518 Histamine:  D08040<US> Histamine phosphate:  D04445<US> Irdabisant (DG01330):  D10128 D10129 Pitolisant (DG03021):  D10749 D11490<US> Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     11255 (HRH3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     11255 (HRH3) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Biogenic amine    Histamine     11255 (HRH3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7tm_4 DUF3367 DUF621 Motif Other DBs NCBI-GeneID:  11255 NCBI-ProteinID:  NP_009163 OMIM:  604525 HGNC:  5184 Ensembl:  ENSG00000101180 Pharos:  Q9Y5N1(Tclin) UniProt:  Q9Y5N1 LinkDB All DBs Position 20:complement(62214960..62220278) Genome browser AA seq 445 aa AA seqDB search MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR RAFTKLLCPQKLKIQPHSSLEHCWK NT seq 1338 nt NT seq  +upstreamnt  +downstreamnt atggagcgcgcgccgcccgacgggccgctgaacgcttcgggggcgctggcgggcgaggcg gcggcggcgggcggggcgcgcggcttctcggcagcctggaccgcggtgctggccgcgctc atggcgctgctcatcgtggccacggtgctgggcaacgcgctggtcatgctcgccttcgtg gccgactcgagcctccgcacccagaacaacttcttcctgctcaacctcgccatctccgac ttcctcgtcggcgccttctgcatcccactgtatgtaccctacgtgctgacaggccgctgg accttcggccggggcctctgcaagctgtggctggtagtggactacctgctgtgcacctcc tctgccttcaacatcgtgctcatcagctacgaccgcttcctgtcggtcacccgagcggtc tcataccgggcccagcagggtgacacgcggcgggcagtgcggaagatgctgctggtgtgg gtgctggccttcctgctgtacggaccagccatcctgagctgggagtacctgtccgggggc agctccatccccgagggccactgctatgccgagttcttctacaactggtacttcctcatc acggcttccaccctggagttctttacgcccttcctcagcgtcaccttctttaacctcagc atctacctgaacatccagaggcgcacccgcctccggctggatggggctcgagaggcagcc ggccccgagccccctcccgaggcccagccctcaccacccccaccgcctggctgctggggc tgctggcagaaggggcacggggaggccatgccgctgcacaggtatggggtgggtgaggcg gccgtaggcgctgaggccggggaggcgaccctcgggggtggcggtgggggcggctccgtg gcttcacccacctccagctccggcagctcctcgaggggcactgagaggccgcgctcactc aagaggggctccaagccgtcggcgtcctcggcctcgctggagaagcgcatgaagatggtg tcccagagcttcacccagcgctttcggctgtctcgggacaggaaagtggccaagtcgctg gccgtcatcgtgagcatctttgggctctgctgggccccatacacgctgctgatgatcatc cgggccgcctgccatggccactgcgtccctgactactggtacgaaacctccttctggctc ctgtgggccaactcggctgtcaaccctgtcctctaccctctgtgccaccacagcttccgc cgggccttcaccaagctgctctgcccccagaagctcaaaatccagccccacagctccctg gagcactgctggaagtga

Homo sapiens (human): 3269 Help Entry 3269              CDS       T01001                                  Symbol HRH1, H1-R, H1R, HH1R, hisH1 Name (RefSeq) histamine receptor H1   KO K04149   histamine receptor H1 Organism hsa  Homo sapiens (human) Pathway hsa04020   Calcium signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04750   Inflammatory mediator regulation of TRP channels Drug target Acrivastine:  D02760 Alcaftadine:  D06552<US> Alimemazine (DG01101):  D02245<JP> D07125 Antazoline (DG01037):  D02950 D07458 D07459 Astemizole:  D00234 Azatadine (DG01112):  D00662 D07482 Azelastine (DG01036):  D00659<JP/US> D07483 Bamipine (DG00388):  D07197 D07492 D07493 Barmastine:  D03056 Bepotastine (DG01327):  D01654<JP/US> D09705 Betahistine (DG01004):  D01592<JP> D03102 D07522 Bilastine:  D09570<JP> Bisulepin:  D07532 Bisulepin hydrochloride:  D07533 Broizine:  D09838 Bromazine:  D03166 Brompheniramine (DG01097):  D00663 D07543 Buclizine (DG01104):  D02089 D07547 Carbinoxamine (DG01095):  D01336<US> D07617 D09808 Cetirizine (DG01107):  D00664<JP/US> D07662 Chloropyramine (DG00384):  D07195 D07679 Chlorphenamine (DG01099):  D00665<JP> D03475 D07398 Chlorphenoxamine (DG00391):  D07198 D07684 Chlorpromazine (DG00867):  D00270 D00789<JP/US> D03274 D04034<JP> D09819 Cidoxepin hydrochloride:  D03491 Cinnarizine (DG01005):  D01295 D07734 Clemastine (DG00387):  D00666<JP/US> D03535 Closiramine aceturate:  D03568 Cycliramine maleate:  D03620 Cyclizine (DG01105):  D02090 D03621 D03622 Cyproheptadine (DG01109):  D02234<JP/US> D07765 Deptropine (DG01114):  D07404 D07790 Desloratadine:  D03693<JP/US> Dexbrompheniramine:  D03704 Dexchlorpheniramine (DG01098):  D00668<JP/US> D07803 Difeterol (DG02077):  D01701 D09747 D09748 Dimenhydrinate:  D00520<JP/US> Dimetindene (DG00386):  D01343 D07853 Dimetotiazine (DG00843):  D01902<JP> D07854 Dioxopromethazine hydrochloride:  D07860 Diphenhydramine (DG00390):  D00300<JP> D00669<JP/US> D02419 D03285 D03360<JP> D03854 Diphenylimidazole:  D02067 Diphenylpyraline (DG01094):  D01172 D01627 D07862 Dorastine hydrochloride:  D03893 Doxepin (DG00937):  D00814<US> D07875 Doxylamine (DG01096):  D02327 D07878 Ebastine:  D01478<JP> Efletirizine dihydrochloride:  D03963 Embramine:  D07889 Emedastine (DG01144):  D02249<JP> D07890 Epinastine (DG01116):  D01713<JP/US> D07900 Esmirtazapine maleate:  D04055 Fexofenadine (DG01117):  D00671<JP/US> D07958 Histamine:  D08040<US> Histamine phosphate:  D04445<US> Histapyrrodine:  D07400 Homochlorcyclizine (DG01328):  D01460<JP> D08041 Hydroxyzine (DG00912):  D00672<JP/US> D01096<JP/US> D08054 Icotidine:  D04494 Isothipendyl (DG00389):  D01143 D08091 Ketotifen (DG01115):  D01332<JP/US> D08105 Levocabastine (DG01035):  D01717<JP> D08117 Levocetirizine (DG01108):  D07402 D08118<JP/US> Loratadine:  D00364<JP/US> Mebhydrolin (DG01113):  D01786 D08161 Meclozine (DG01106):  D01317<US> D08163 Mepyramine (DG00382):  D05660 D08183 Mequitazine:  D01324<JP> Methdilazine (DG01103):  D04979 D04980 Mianserin (DG00951):  D01358<JP> D08216 Mizolastine:  D01117 Noberastine:  D05196 Olanzapine (DG00898):  D00454<JP/US> D06623<US> Olopatadine (DG01039):  D01192<JP/US> D08293 Opipramol (DG00930):  D01477 D08297 Orphenadrine (DG01252):  D08305 Orphenadrine (chloride):  D02599 Orphenadrine (citrate):  D00774<US> Oxomemazine:  D07401 Phenindamine (DG01110):  D02148 D08353 Pheniramine (DG01100):  D01174 D08355 Phenyltoloxamine citrate:  D08967 Pimethixene:  D07406 Promethazine (DG00385):  D00480<JP/US> D00494 D01242 D03290<JP> D08432 D08768<JP> Pyroxamine maleate:  D05664 Pyrrobutamine:  D07403 Quifenadine:  D10230 Rocastine hydrochloride:  D05742 Rotoxamine:  D05769 Rupatadine (DG01118):  D07407 D08497<JP> Sequifenadine:  D10510 Tazifylline hydrochloride:  D06012 Tecastemizole:  D06021 Temelastine:  D06063 Terfenadine:  D00521 Tesmilifene hydrochloride:  D06084 Thenalidine:  D07194 Thonzylamine (DG00381):  D01801 D08587 Tolpropamine:  D07196 Tripelennamine (DG00383):  D02091 D06246 D08645 Triprolidine (DG01111):  D01782 D08648 Zolamine hydrochloride:  D06376 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04020 Calcium signaling pathway     3269 (HRH1)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     3269 (HRH1)  09150 Organismal Systems   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     3269 (HRH1)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     3269 (HRH1) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Biogenic amine    Histamine     3269 (HRH1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7tm_4 DUF1601 Motif Other DBs NCBI-GeneID:  3269 NCBI-ProteinID:  NP_000852 OMIM:  600167 HGNC:  5182 Ensembl:  ENSG00000196639 Pharos:  P35367(Tclin) UniProt:  P35367 Structure PDB LinkDB All DBs Position 3:11137238..11263557 Genome browser AA seq 487 aa AA seqDB search MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK RILHIRS NT seq 1464 nt NT seq  +upstreamnt  +downstreamnt atgagcctccccaattcctcctgcctcttagaagacaagatgtgtgagggcaacaagacc actatggccagcccccagctgatgcccctggtggtggtcctgagcactatctgcttggtc acagtagggctcaacctgctggtgctgtatgccgtacggagtgagcggaagctccacact gtggggaacctgtacatcgtcagcctctcggtggcggacttgatcgtgggtgccgtcgtc atgcctatgaacatcctctacctgctcatgtccaagtggtcactgggccgtcctctctgc ctcttttggctttccatggactatgtggccagcacagcgtccattttcagtgtcttcatc ctgtgcattgatcgctaccgctctgtccagcagcccctcaggtaccttaagtatcgtacc aagacccgagcctcggccaccattctgggggcctggtttctctcttttctgtgggttatt cccattctaggctggaatcacttcatgcagcagacctcggtgcgccgagaggacaagtgt gagacagacttctatgatgtcacctggttcaaggtcatgactgccatcatcaacttctac ctgcccaccttgctcatgctctggttctatgccaagatctacaaggccgtacgacaacac tgccagcaccgggagctcatcaataggtccctcccttccttctcagaaattaagctgagg ccagagaaccccaagggggatgccaagaaaccagggaaggagtctccctgggaggttctg aaaaggaagccaaaagatgctggtggtggatctgtcttgaagtcaccatcccaaaccccc aaggagatgaaatccccagttgtcttcagccaagaggatgatagagaagtagacaaactc tactgctttccacttgatattgtgcacatgcaggctgcggcagaggggagtagcagggac tatgtagccgtcaaccggagccatggccagctcaagacagatgagcagggcctgaacaca catggggccagcgagatatcagaggatcagatgttaggtgatagccaatccttctctcga acggactcagataccaccacagagacagcaccaggcaaaggcaaattgaggagtgggtct aacacaggcctggattacatcaagtttacttggaagaggctccgctcgcattcaagacag tatgtatctgggttgcacatgaaccgcgaaaggaaggccgccaaacagttgggttttatc atggcagccttcatcctctgctggatcccttatttcatcttcttcatggtcattgccttc tgcaagaactgttgcaatgaacatttgcacatgttcaccatctggctgggctacatcaac tccacactgaaccccctcatctaccccttgtgcaatgagaacttcaagaagacattcaag agaattctgcatattcgctcctaa

Homo sapiens (human): 3274 Help Entry 3274              CDS       T01001                                  Symbol HRH2, H2R, HH2R Name (RefSeq) histamine receptor H2   KO K04150   histamine receptor H2 Organism hsa  Homo sapiens (human) Pathway hsa04020   Calcium signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04971   Gastric acid secretion Drug target Betazole:  D01187 Cimetidine (DG00017):  D00295<JP/US> D03503<US> Dalcotidine:  D01698 Donetidine:  D03889 Etintidine hydrochloride:  D04098 Famotidine:  D00318<JP/US> Histamine:  D08040<US> Histamine phosphate:  D04445<US> Icotidine:  D04494 Impromidine hydrochloride:  D04517 Lafutidine:  D01131<JP> Lavoltidine succinate:  D04680 Lupitidine hydrochloride:  D04794 Methantheline (DG00036):  D00721 Metiamide:  D05004 Niperotidine:  D07072 Nizatidine:  D00440<JP/US> Osutidine:  D01193 Oxmetidine (DG01225):  D05306 D05307 Pibutidine hydrochloride:  D01861 Ranitidine (DG00018):  D00422 D00673<JP/US> Ranitidine bismuth citrate:  D05699 Roxatidine (DG00019):  D01467<JP> D08494 D08495 Sufotidine:  D05939 Tiotidine:  D06157 Zaltidine hydrochloride:  D06355 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04020 Calcium signaling pathway     3274 (HRH2)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     3274 (HRH2)  09150 Organismal Systems   09154 Digestive system    04971 Gastric acid secretion     3274 (HRH2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     3274 (HRH2) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Biogenic amine    Histamine     3274 (HRH2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7tm_4 Motif Other DBs NCBI-GeneID:  3274 NCBI-ProteinID:  NP_001124527 OMIM:  142703 HGNC:  5183 Ensembl:  ENSG00000113749 Pharos:  P25021(Tclin) UniProt:  P25021 LinkDB All DBs Position 5:175658071..175710756 Genome browser AA seq 397 aa AA seqDB search MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDRP WLCLPECWSVELTHSFIHLFIHSFANIHPIPTTCQEL NT seq 1194 nt NT seq  +upstreamnt  +downstreamnt atggcacccaatggcacagcctcttccttttgcctggactctaccgcatgcaagatcacc atcaccgtggtccttgcggtcctcatcctcatcaccgttgctggcaatgtggtcgtctgt ctggccgtgggcttgaaccgccggctccgcaacctgaccaattgtttcatcgtgtccttg gctatcactgacctgctcctcggcctcctggtgctgcccttctctgccatctaccagctg tcctgcaagtggagctttggcaaggtcttctgcaatatctacaccagcctggatgtgatg ctctgcacagcctccattcttaacctcttcatgatcagcctcgaccggtactgcgctgtc atggacccactgcggtaccctgtgctggtcaccccagttcgggtcgccatctctctggtc ttaatttgggtcatctccattaccctgtcctttctgtctatccacctggggtggaacagc aggaacgagaccagcaagggcaatcataccacctctaagtgcaaagtccaggtcaatgaa gtgtacgggctggtggatgggctggtcaccttctacctcccgctactgatcatgtgcatc acctactaccgcatcttcaaggtcgcccgggatcaggccaagaggatcaatcacattagc tcctggaaggcagccaccatcagggagcacaaagccacagtgacactggccgccgtcatg ggggccttcatcatctgctggtttccctacttcaccgcgtttgtgtaccgtgggctgaga ggggatgatgccatcaatgaggtgttagaagccatcgttctgtggctgggctatgccaac tcagccctgaaccccatcctgtatgctgcgctgaacagagacttccgcaccgggtaccaa cagctcttctgctgcaggctggccaaccgcaactcccacaaaacttctctgaggtccaac gcctctcagctgtccaggacccaaagccgagaacccaggcaacaggaagagaaacccctg aagctccaggtgtggagtgggacagaagtcacggccccccagggagccacagacagacca tggctttgccttccagaatgctggtctgtggaactgacccattcattcattcatttgttc attcattcatttgcaaacattcatccaattcccaccacatgccaggaattatga

Homo sapiens (human): 59340 Help Entry 59340             CDS       T01001                                  Symbol HRH4, AXOR35, BG26, GPCR105, GPRv53, H4, H4R, HH4R Name (RefSeq) histamine receptor H4   KO K04152   histamine receptor H4 Organism hsa  Homo sapiens (human) Pathway hsa04080   Neuroactive ligand-receptor interaction Drug target Adriforant:  D11819 Histamine:  D08040<US> Toreforant (DG01866):  D10735 D10736 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     59340 (HRH4)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     59340 (HRH4) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Biogenic amine    Histamine     59340 (HRH4) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7tm_4 MPS-4 Motif Other DBs NCBI-GeneID:  59340 NCBI-ProteinID:  NP_067637 OMIM:  606792 HGNC:  17383 Ensembl:  ENSG00000134489 Pharos:  Q9H3N8(Tchem) UniProt:  Q9H3N8 LinkDB All DBs Position 18:24460637..24479974 Genome browser AA seq 390 aa AA seqDB search MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS NT seq 1173 nt NT seq  +upstreamnt  +downstreamnt atgccagatactaatagcacaatcaatttatcactaagcactcgtgttactttagcattt tttatgtccttagtagcttttgctataatgctaggaaatgctttggtcattttagctttt gtggtggacaaaaaccttagacatcgaagtagttatttttttcttaacttggccatctct gacttctttgtgggtgtgatctccattcctttgtacatccctcacacgctgttcgaatgg gattttggaaaggaaatctgtgtattttggctcactactgactatctgttatgtacagca tctgtatataacattgtcctcatcagctatgatcgatacctgtcagtctcaaatgctgtg tcttatagaactcaacatactggggtcttgaagattgttactctgatggtggccgtttgg gtgctggccttcttagtgaatgggccaatgattctagtttcagagtcttggaaggatgaa ggtagtgaatgtgaacctggatttttttcggaatggtacatccttgccatcacatcattc ttggaattcgtgatcccagtcatcttagtcgcttatttcaacatgaatatttattggagc ctgtggaagcgtgatcatctcagtaggtgccaaagccatcctggactgactgctgtctct tccaacatctgtggacactcattcagaggtagactatcttcaaggagatctctttctgca tcgacagaagttcctgcatcctttcattcagagagacagaggagaaagagtagtctcatg ttttcctcaagaaccaagatgaatagcaatacaattgcttccaaaatgggttccttctcc caatcagattctgtagctcttcaccaaagggaacatgttgaactgcttagagccaggaga ttagccaagtcactggccattctcttaggggtttttgctgtttgctgggctccatattct ctgttcacaattgtcctttcattttattcctcagcaacaggtcctaaatcagtttggtat agaattgcattttggcttcagtggttcaattcctttgtcaatcctcttttgtatccattg tgtcacaagcgctttcaaaaggctttcttgaaaatattttgtataaaaaagcaacctcta ccatcacaacacagtcggtcagtatcttcttaa

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