Homo sapiens (human): 1128 Help Entry 1128              CDS       T01001                                  Symbol CHRM1, HM1, M1, M1R Name (RefSeq) cholinergic receptor muscarinic 1   KO K04129   muscarinic acetylcholine receptor M1 Organism hsa  Homo sapiens (human) Pathway hsa04020   Calcium signaling pathway hsa04024   cAMP signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04151   PI3K-Akt signaling pathway hsa04725   Cholinergic synapse hsa04810   Regulation of actin cytoskeleton hsa05010   Alzheimer disease hsa05022   Pathways of neurodegeneration - multiple diseases Network nt06410  Calcium signaling nt06460  Alzheimer disease   Element N01000   mAChR-Ca2+ -apoptotic pathway N01001   Mutation-caused aberrant Abeta to mAchR-Ca2+ -apoptotic pathway Drug target Aceclidine:  D02750 Acetylcholine (DG01133):  D00999<JP/US> Aclatonium (DG01291):  D01955 Aclidinium bromide:  D08837<JP/US> Alvameline maleate:  D02876 Anisotropine methylbromide:  D00232 Atropine (DG00052):  D00113<US> D02069<JP/US> Atropine oxide (DG01243):  D03011 D07477 Batefenterol (DG01627):  D10545 D10546 Benapryzine hydrochloride:  D03076 Benzatropine (DG00859):  D00778<US> D07511 Benzetimide (DG01301):  D03087 D07513 Benzilone:  D03088 Bethanechol (DG00991):  D01000<JP/US> Bevonium:  D01532 Biperiden (DG00852):  D00779 D02246<JP> D02247<JP> Blarcamesine (DG03048):  D11383 D11549 Bornaprine:  D07302 Butropium bromide:  D01491<JP> Butylscopolamine:  D01451<JP> Carbachol:  D00524<US> Carpronium (DG01289):  D01175<JP> D09752<JP> Chlorpromazine (DG00867):  D00270 D00789<JP/US> D03274 D04034<JP> D09819 Choline alfoscerate:  D07349 Cimetropium bromide:  D07099 Clidinium bromide:  D00716 Cyclopentolate (DG01141):  D01002<JP/US> D07759 Darotropium bromide:  D09402 Dexetimide (DG00856):  D03711 D07804 Dicycloverine (DG00032):  D00717<US> D07820 Diethazine (DG01921):  D02603 D07823 Difemerine:  D07079 Dihexyverine (DG00033):  D03824 D07821 Diphenidol (DG02880):  D01318<JP> D03858 D03859 Diphenylpiperidinomethyldioxolan iodide:  D01600 Diponium bromide:  D01463 Elantrine:  D03970 Elucaine:  D03979 Esoxybutynin chloride:  D04057 Etomidoline:  D01359 Etybenzatropine:  D04087 Eucatropine hydrochloride:  D04116 Fenpiverinium:  D07070 Fentonium:  D07951 Flutropium bromide:  D02417 Glycopyrronium (DG02467):  D10939<JP/US> Heteronium bromide:  D04434 Homatropine (DG01142):  D01004 Homatropine methylbromide:  D02070 Hyoscyamine (DG00053):  D00147 D00719 D01648 D04479 Imidafenacin:  D06273<JP> Ipratropium bromide:  D02212<JP/US> Mazaticol (DG00857):  D03264<JP> D08157 Mebeverine (DG00030):  D04868 D08160 Mepenzolate (DG00040):  D00720<JP> Methacholine:  D04970<JP/US> Methantheline (DG00036):  D00721 Methscopolamine bromide:  D00715<US> Methylatropine (DG01242):  D01077 D03814 Methylbenactyzium bromide:  D01315 Methylscopolamine:  D01976<JP> Metixene (DG00853):  D01871 D08209 Metoquizine:  D05012 Milameline hydrochloride:  D05035 Otilonium bromide:  D07083 Oxapium iodide:  D01815 Oxitropium bromide:  D01946 Oxybutynin (DG00478):  D00465<US> D00722<JP/US> Oxyphencyclimine (DG00029):  D01006 D08325 Oxyphenonium:  D06877 Parapenzolate bromide:  D05360 Pentapiperium methylsulfate:  D05418 Penthienate:  D07081 Phencarbamide:  D05452 Phenglutarimide:  D07301 Pipenzolate:  D07084 Piperidolate (DG00034):  D01165<JP> D08382 Pipethanate (DG01255):  D01521 D08384 Pipethanate ethobromide:  D01987 Pirenzepine (DG00026):  D01297 D05276<JP> D08389 Piroheptine (DG01272):  D01231<JP> D08395 Poldine:  D05535 Pridinol (DG00774):  D02064<JP> D08418 D08419 Prifinium bromide:  D01377 Procyclidine (DG00854):  D00782 D08425 Profenamine (DG00855):  D01118 D03276 D08426 Propantheline (DG00035):  D00481<JP/US> Propenzolate hydrochloride:  D05628 Propiverine (DG00479):  D01007<JP> D08441 Rapacuronium bromide:  D05703 Rocuronium bromide:  D00765<JP/US> Sabcomeline hydrochloride:  D05779 Scopolamine (DG00065):  D00138<US> D02071<JP> Talsaclidine fumarate:  D06000 Tazomeline citrate:  D06015 Telenzepine hydrochloride hydrate:  D11098 Tematropium methylsulfate:  D06061 Tiemonium (DG01254):  D08595 Tiemonium iodide:  D01201 Timepidium bromide (DG00041):  D02535<JP> Tofenacin hydrochloride:  D06175 Toquizine:  D06192 Triampyzine sulfate:  D06217 Tridihexethyl (DG00037):  D00723 Trihexyphenidyl (DG00851):  D00787<JP/US> D08638 Tropatepine (DG00858):  D07303 D08653 Tropicamide:  D00397<JP/US> Umeclidinium (DG01253):  D10180 Umeclidinium bromide:  D10181<JP/US> Valethamate:  D01538 Xanomeline (DG01300):  D06330 D06331 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04020 Calcium signaling pathway     1128 (CHRM1)    04024 cAMP signaling pathway     1128 (CHRM1)    04151 PI3K-Akt signaling pathway     1128 (CHRM1)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     1128 (CHRM1)  09140 Cellular Processes   09142 Cell motility    04810 Regulation of actin cytoskeleton     1128 (CHRM1)  09150 Organismal Systems   09156 Nervous system    04725 Cholinergic synapse     1128 (CHRM1)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     1128 (CHRM1)    05022 Pathways of neurodegeneration - multiple diseases     1128 (CHRM1)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     1128 (CHRM1) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Biogenic amine    Acetylcholine (muscarinic)     1128 (CHRM1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srbc 7TM_GPCR_Srx Motif Other DBs NCBI-GeneID:  1128 NCBI-ProteinID:  NP_000729 OMIM:  118510 HGNC:  1950 Ensembl:  ENSG00000168539 Vega:  OTTHUMG00000167765 Pharos:  P11229(Tclin) UniProt:  P11229 Q53XZ3 Structure PDB LinkDB All DBs Position 11:complement(62908679..62921878) Genome browser AA seq 460 aa AA seqDB search MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS SERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV VIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYAL CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC NT seq 1383 nt NT seq  +upstreamnt  +downstreamnt atgaacacttcagccccacctgctgtcagccccaacatcaccgtcctggcaccaggaaag ggtccctggcaagtggccttcattgggatcaccacgggcctcctgtcgctagccacagtg acaggcaacctgctggtactcatctctttcaaggtcaacacggagctcaagacagtcaat aactacttcctgctgagcctggcctgtgctgacctcatcatcggtaccttctccatgaac ctctataccacgtacctgctcatgggccactgggctctgggcacgctggcttgtgacctc tggctggccctggactatgtggccagcaatgcctccgtcatgaatctgctgctcatcagc tttgaccgctacttctccgtgactcggcccctgagctaccgtgccaagcgcacaccccgc cgggcagctctgatgatcggcctggcctggctggtttcctttgtgctctgggccccagcc atcctcttctggcagtacctggtaggggagcggacagtgctagctgggcagtgctacatc cagttcctctcccagcccatcatcacctttggcacagccatggctgccttctacctccct gtcacagtcatgtgcacgctctactggcgcatctaccgggagacagagaaccgagcacgg gagctggcagcccttcagggctccgagacgccaggcaaagggggtggcagcagcagcagc tcagagaggtctcagccaggggctgagggctcaccagagactcctccaggccgctgctgt cgctgctgccgggcccccaggctgctgcaggcctacagctggaaggaagaagaggaagag gacgaaggctccatggagtccctcacatcctcagagggagaggagcctggctccgaagtg gtgatcaagatgccaatggtggaccccgaggcacaggcccccaccaagcagcccccacgg agctccccaaatacagtcaagaggccgactaagaaagggcgtgatcgagctggcaagggc cagaagccccgtggaaaggagcagctggccaagcggaagaccttctcgctggtcaaggag aagaaggcggctcggaccctgagtgccatcctcctggccttcatcctcacctggacaccg tacaacatcatggtgctggtgtccaccttctgcaaggactgtgttcccgagaccctgtgg gagctgggctactggctgtgctacgtcaacagcaccatcaaccccatgtgctacgcactc tgcaacaaagccttccgggacacctttcgcctgctgctgctttgccgctgggacaagaga cgctggcgcaagatccccaagcgccctggctccgtgcaccgcactccctcccgccaatgc tga

Homo sapiens (human): 1129 Help Entry 1129              CDS       T01001                                  Symbol CHRM2, HM2 Name (RefSeq) cholinergic receptor muscarinic 2   KO K04130   muscarinic acetylcholine receptor M2 Organism hsa  Homo sapiens (human) Pathway hsa04020   Calcium signaling pathway hsa04024   cAMP signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04151   PI3K-Akt signaling pathway hsa04725   Cholinergic synapse hsa04810   Regulation of actin cytoskeleton Drug target Acetylcholine (DG01133):  D00999<JP/US> Aclatonium (DG01291):  D01955 Aclidinium bromide:  D08837<JP/US> Alvameline maleate:  D02876 Anisotropine methylbromide:  D00232 Atropine (DG00052):  D00113<US> D02069<JP/US> Atropine oxide (DG01243):  D03011 D07477 Batefenterol (DG01627):  D10545 D10546 Benapryzine hydrochloride:  D03076 Benzatropine (DG00859):  D00778<US> D07511 Benzetimide (DG01301):  D03087 D07513 Benzilone:  D03088 Bethanechol (DG00991):  D01000<JP/US> Bevonium:  D01532 Biperiden (DG00852):  D00779 D02246<JP> D02247<JP> Blarcamesine (DG03048):  D11383 D11549 Bornaprine:  D07302 Butropium bromide:  D01491<JP> Butylscopolamine:  D01451<JP> Carbachol:  D00524<US> Carpronium (DG01289):  D01175<JP> D09752<JP> Chlorpromazine (DG00867):  D00270 D00789<JP/US> D03274 D04034<JP> D09819 Choline alfoscerate:  D07349 Cimetropium bromide:  D07099 Clidinium bromide:  D00716 Cyclopentolate (DG01141):  D01002<JP/US> D07759 Darotropium bromide:  D09402 Dexetimide (DG00856):  D03711 D07804 Dicycloverine (DG00032):  D00717<US> D07820 Diethazine (DG01921):  D02603 D07823 Difemerine:  D07079 Dihexyverine (DG00033):  D03824 D07821 Dimetindene (DG00386):  D07853 Diphenidol (DG02880):  D01318<JP> D03858 D03859 Diphenylpiperidinomethyldioxolan iodide:  D01600 Diponium bromide:  D01463 Elantrine:  D03970 Elucaine:  D03979 Esoxybutynin chloride:  D04057 Etomidoline:  D01359 Etybenzatropine:  D04087 Eucatropine hydrochloride:  D04116 Fenpiverinium:  D07070 Fentonium:  D07951 Fesoterodine (DG00483):  D07226 D08923<JP/US> Flutropium bromide:  D02417 Gallamine:  D02292 Glycopyrronium (DG02467):  D10939<JP/US> Heteronium bromide:  D04434 Homatropine (DG01142):  D01004 Homatropine methylbromide:  D02070 Hyoscyamine (DG00053):  D00147 D00719 D01648 D04479 Ipratropium bromide:  D02212<JP/US> Mazaticol (DG00857):  D03264<JP> D08157 Mebeverine (DG00030):  D04868 D08160 Mepenzolate (DG00040):  D00720<JP> Methacholine:  D04970<JP/US> Methantheline (DG00036):  D00721 Methscopolamine bromide:  D00715<US> Methylatropine (DG01242):  D01077 D03814 Methylbenactyzium bromide:  D01315 Methylscopolamine:  D01976<JP> Metixene (DG00853):  D01871 D08209 Metoquizine:  D05012 Milameline hydrochloride:  D05035 Otilonium bromide:  D07083 Oxapium iodide:  D01815 Oxitropium bromide:  D01946 Oxybutynin (DG00478):  D00465<US> D00722<JP/US> Oxyphencyclimine (DG00029):  D01006 D08325 Parapenzolate bromide:  D05360 Pentapiperium methylsulfate:  D05418 Penthienate:  D07081 Phencarbamide:  D05452 Phenglutarimide:  D07301 Pilocarpine (DG00992):  D00525 D02200<JP/US> D05478 D08376 Pipenzolate:  D07084 Piperidolate (DG00034):  D01165<JP> D08382 Pipethanate (DG01255):  D01521 D08384 Pipethanate ethobromide:  D01987 Pirenzepine (DG00026):  D01297 D05276<JP> D08389 Piroheptine (DG01272):  D01231<JP> D08395 Poldine:  D05535 Pridinol (DG00774):  D02064<JP> D08418 D08419 Prifinium bromide:  D01377 Procyclidine (DG00854):  D00782 D08425 Profenamine (DG00855):  D01118 D03276 D08426 Propantheline (DG00035):  D00481<JP/US> Propenzolate hydrochloride:  D05628 Propiverine (DG00479):  D01007<JP> D08441 Rapacuronium bromide:  D05703 Rocuronium bromide:  D00765<JP/US> Scopolamine (DG00065):  D00138<US> D02071<JP> Tazomeline citrate:  D06015 Tematropium methylsulfate:  D06061 Tiemonium (DG01254):  D08595 Tiemonium iodide:  D01201 Timepidium bromide (DG00041):  D02535<JP> Tofenacin hydrochloride:  D06175 Toquizine:  D06192 Triampyzine sulfate:  D06217 Tridihexethyl (DG00037):  D00723 Trihexyphenidyl (DG00851):  D00787<JP/US> D08638 Tropatepine (DG00858):  D07303 D08653 Tropicamide:  D00397<JP/US> Trospium:  D01103<US> Umeclidinium (DG01253):  D10180 Umeclidinium bromide:  D10181<JP/US> Valethamate:  D01538 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04020 Calcium signaling pathway     1129 (CHRM2)    04024 cAMP signaling pathway     1129 (CHRM2)    04151 PI3K-Akt signaling pathway     1129 (CHRM2)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     1129 (CHRM2)  09140 Cellular Processes   09142 Cell motility    04810 Regulation of actin cytoskeleton     1129 (CHRM2)  09150 Organismal Systems   09156 Nervous system    04725 Cholinergic synapse     1129 (CHRM2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     1129 (CHRM2) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Biogenic amine    Acetylcholine (muscarinic)     1129 (CHRM2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  7tm_1 7tm_4 Macoilin Motif Other DBs NCBI-GeneID:  1129 NCBI-ProteinID:  NP_000730 OMIM:  118493 HGNC:  1951 Ensembl:  ENSG00000181072 Vega:  OTTHUMG00000155658 Pharos:  P08172(Tclin) UniProt:  P08172 A4D1Q0 Q86SJ1 Q6SL56 Structure PDB LinkDB All DBs Position 7:136868652..137020213 Genome browser AA seq 466 aa AA seqDB search MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR NT seq 1401 nt NT seq  +upstreamnt  +downstreamnt atgaataactcaacaaactcctctaacaatagcctggctcttacaagtccttataagaca tttgaagtggtgtttattgtcctggtggctggatccctcagtttggtgaccattatcggg aacatcctagtcatggtttccattaaagtcaaccgccacctccagaccgtcaacaattac tttttattcagcttggcctgtgctgaccttatcataggtgttttctccatgaacttgtac accctctacactgtgattggttactggcctttgggacctgtggtgtgtgacctttggcta gccctggactatgtggtcagcaatgcctcagttatgaatctgctcatcatcagctttgac aggtacttctgtgtcacaaaacctctgacctacccagtcaagcggaccacaaaaatggca ggtatgatgattgcagctgcctgggtcctctctttcatcctctgggctccagccattctc ttctggcagttcattgtaggggtgagaactgtggaggatggggagtgctacattcagttt ttttccaatgctgctgtcacctttggtacggctattgcagccttctatttgccagtgatc atcatgactgtgctatattggcacatatcccgagccagcaagagcaggataaagaaggac aagaaggagcctgttgccaaccaagaccccgtttctccaagtctggtacaaggaaggata gtgaagccaaacaataacaacatgcccagcagtgacgatggcctggagcacaacaaaatc cagaatggcaaagcccccagggatcctgtgactgaaaactgtgttcagggagaggagaag gagagctccaatgactccacctcagtcagtgctgttgcctctaatatgagagatgatgaa ataacccaggatgaaaacacagtttccacttccctgggccattccaaagatgagaactct aagcaaacatgcatcagaattggcaccaagaccccaaaaagtgactcatgtaccccaact aataccaccgtggaggtagtggggtcttcaggtcagaatggagatgaaaagcagaatatt gtagcccgcaagattgtgaagatgactaagcagcctgcaaaaaagaagcctcctccttcc cgggaaaagaaagtcaccaggacaatcttggctattctgttggctttcatcatcacttgg gccccatacaatgtcatggtgctcattaacaccttttgtgcaccttgcatccccaacact gtgtggacaattggttactggctttgttacatcaacagcactatcaaccctgcctgctat gcactttgcaatgccaccttcaagaagacctttaaacaccttctcatgtgtcattataag aacataggcgctacaaggtaa

Homo sapiens (human): 1131 Help Entry 1131              CDS       T01001                                  Symbol CHRM3, EGBRS, HM3, PBS Name (RefSeq) cholinergic receptor muscarinic 3   KO K04131   muscarinic acetylcholine receptor M3 Organism hsa  Homo sapiens (human) Pathway hsa04020   Calcium signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04725   Cholinergic synapse hsa04742   Taste transduction hsa04810   Regulation of actin cytoskeleton hsa04911   Insulin secretion hsa04970   Salivary secretion hsa04971   Gastric acid secretion hsa04972   Pancreatic secretion hsa05010   Alzheimer disease hsa05022   Pathways of neurodegeneration - multiple diseases Network nt06410  Calcium signaling nt06460  Alzheimer disease   Element N01000   mAChR-Ca2+ -apoptotic pathway N01001   Mutation-caused aberrant Abeta to mAchR-Ca2+ -apoptotic pathway Disease H02129   Prune belly syndrome Drug target Acetylcholine (DG01133):  D00999<JP/US> Aclatonium (DG01291):  D01955 Aclidinium bromide:  D08837<JP/US> Alvameline maleate:  D02876 Anisotropine methylbromide:  D00232 Atropine (DG00052):  D00113<US> D02069<JP/US> Atropine oxide (DG01243):  D03011 D07477 Batefenterol (DG01627):  D10545 D10546 Benapryzine hydrochloride:  D03076 Benzatropine (DG00859):  D00778<US> D07511 Benzetimide (DG01301):  D03087 D07513 Benzilone:  D03088 Bethanechol (DG00991):  D01000<JP/US> Bevonium:  D01532 Biperiden (DG00852):  D00779 D02246<JP> D02247<JP> Blarcamesine (DG03048):  D11383 D11549 Bornaprine:  D07302 Butropium bromide:  D01491<JP> Butylscopolamine:  D01451<JP> Carbachol:  D00524<US> Carpronium (DG01289):  D01175<JP> D09752<JP> Cevimeline (DG00993):  D00661<JP/US> D07667 Chlorpromazine (DG00867):  D00270 D00789<JP/US> D03274 D04034<JP> D09819 Choline alfoscerate:  D07349 Cimetropium bromide:  D07099 Clidinium bromide:  D00716 Cyclopentolate (DG01141):  D01002<JP/US> D07759 Darifenacin (DG00482):  D01699<US> D03654 Darotropium bromide:  D09402 Desfesoterodine:  D10853 Dexetimide (DG00856):  D03711 D07804 Dexpanthenol:  D00193<JP> Dicycloverine (DG00032):  D00717<US> D07820 Diethazine (DG01921):  D02603 D07823 Difemerine:  D07079 Dihexyverine (DG00033):  D03824 D07821 Diphemanil:  D06878 Diphenidol (DG02880):  D01318<JP> D03858 D03859 Diphenylpiperidinomethyldioxolan iodide:  D01600 Diponium bromide:  D01463 Elantrine:  D03970 Elucaine:  D03979 Esoxybutynin chloride:  D04057 Etomidoline:  D01359 Etybenzatropine:  D04087 Eucatropine hydrochloride:  D04116 Fenpiverinium:  D07070 Fentonium:  D07951 Fesoterodine (DG00483):  D07226 D08923<JP/US> Flutropium bromide:  D02417 Glycopyrronium:  D00540<JP/US> Glycopyrronium (DG02467):  D10938 D10939<JP/US> Heteronium bromide:  D04434 Hexocyclium (DG00039):  D01003 Homatropine (DG01142):  D01004 Homatropine methylbromide:  D02070 Hyoscyamine (DG00053):  D00147 D00719 D01648 D04479 Imidafenacin:  D06273<JP> Ipratropium bromide:  D02212<JP/US> Isopropamide (DG00038):  D01005 Mazaticol (DG00857):  D03264<JP> D08157 Mebeverine (DG00030):  D04868 D08160 Mepenzolate (DG00040):  D00720<JP> Methacholine:  D04970<JP/US> Methantheline (DG00036):  D00721 Methscopolamine bromide:  D00715<US> Methylatropine (DG01242):  D01077 D03814 Methylbenactyzium bromide:  D01315 Methylscopolamine:  D01976<JP> Metixene (DG00853):  D01871 D08209 Metoquizine:  D05012 Milameline hydrochloride:  D05035 Navafenterol (DG03123):  D11900 D11901 Otilonium bromide:  D07083 Oxapium iodide:  D01815 Oxitropium bromide:  D01946 Oxybutynin (DG00478):  D00465<US> D00722<JP/US> Oxyphencyclimine (DG00029):  D01006 D08325 Parapenzolate bromide:  D05360 Pentapiperium methylsulfate:  D05418 Penthienate:  D07081 Phencarbamide:  D05452 Phenglutarimide:  D07301 Pilocarpine (DG00992):  D00525 D02200<JP/US> D05478 D08376 Pipenzolate:  D07084 Piperidolate (DG00034):  D01165<JP> D08382 Pipethanate (DG01255):  D01521 D08384 Pipethanate ethobromide:  D01987 Pirenzepine (DG00026):  D01297 D05276<JP> D08389 Piroheptine (DG01272):  D01231<JP> D08395 Poldine:  D05535 Pridinol (DG00774):  D02064<JP> D08418 D08419 Prifinium bromide:  D01377 Procyclidine (DG00854):  D00782 D08425 Profenamine (DG00855):  D01118 D03276 D08426 Propantheline (DG00035):  D00481<JP/US> Propenzolate hydrochloride:  D05628 Propiverine (DG00479):  D01007<JP> D08441 Rapacuronium bromide:  D05703 Revefenacin:  D10978<US> Rociverine:  D07078 Rocuronium bromide:  D00765<JP/US> Scopolamine (DG00065):  D00138<US> D02071<JP> Sofpironium bromide:  D10989<JP> Solifenacin (DG00481):  D01269<JP/US> D08522 Tazomeline citrate:  D06015 Tematropium methylsulfate:  D06061 Tiemonium (DG01254):  D08595 Tiemonium iodide:  D01201 Timepidium bromide (DG00041):  D02535<JP> Tiotropium bromide:  D01929<JP/US> Tiquizium bromide:  D01875<JP> Tofenacin hydrochloride:  D06175 Tolterodine (DG00480):  D00646 D01148<JP/US> Toquizine:  D06192 Triampyzine sulfate:  D06217 Tridihexethyl (DG00037):  D00723 Trihexyphenidyl (DG00851):  D00787<JP/US> D08638 Tropatepine (DG00858):  D07303 D08653 Tropicamide:  D00397<JP/US> Trospium:  D01103<US> Umeclidinium (DG01253):  D10180 Umeclidinium bromide:  D10181<JP/US> Valethamate:  D01538 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04020 Calcium signaling pathway     1131 (CHRM3)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     1131 (CHRM3)  09140 Cellular Processes   09142 Cell motility    04810 Regulation of actin cytoskeleton     1131 (CHRM3)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     1131 (CHRM3)   09154 Digestive system    04970 Salivary secretion     1131 (CHRM3)    04971 Gastric acid secretion     1131 (CHRM3)    04972 Pancreatic secretion     1131 (CHRM3)   09156 Nervous system    04725 Cholinergic synapse     1131 (CHRM3)   09157 Sensory system    04742 Taste transduction     1131 (CHRM3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     1131 (CHRM3)    05022 Pathways of neurodegeneration - multiple diseases     1131 (CHRM3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     1131 (CHRM3) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Biogenic amine    Acetylcholine (muscarinic)     1131 (CHRM3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srbc Motif Other DBs NCBI-GeneID:  1131 NCBI-ProteinID:  NP_000731 OMIM:  118494 HGNC:  1952 Ensembl:  ENSG00000133019 Vega:  OTTHUMG00000039649 Pharos:  P20309(Tclin) UniProt:  P20309 A0A024R3W1 Structure PDB LinkDB All DBs Position 1:239386568..239915450 Genome browser AA seq 590 aa AA seqDB search MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPL GGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVI SMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR TTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAF YMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSM KRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSE TRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSF PKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKR MSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVN PVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL NT seq 1773 nt NT seq  +upstreamnt  +downstreamnt atgaccttgcacaataacagtacaacctcgcctttgtttccaaacatcagctcctcctgg atacacagcccctccgatgcagggctgcccccgggaaccgtcactcatttcggcagctac aatgtttctcgagcagctggcaatttctcctctccagacggtaccaccgatgaccctctg ggaggtcataccgtctggcaagtggtcttcatcgctttcttaacgggcatcctggccttg gtgaccatcatcggcaacatcctggtaattgtgtcatttaaggtcaacaagcagctgaag acggtcaacaactacttcctcttaagcctggcctgtgccgatctgattatcggggtcatt tcaatgaatctgtttacgacctacatcatcatgaatcgatgggccttagggaacttggcc tgtgacctctggcttgccattgactacgtagccagcaatgcctctgttatgaatcttctg gtcatcagctttgacagatacttttccatcacgaggccgctcacgtaccgagccaaacga acaacaaagagagccggtgtgatgatcggtctggcttgggtcatctcctttgtcctttgg gctcctgccatcttgttctggcaatactttgttggaaagagaactgtgcctccgggagag tgcttcattcagttcctcagtgagcccaccattacttttggcacagccatcgctgctttt tatatgcctgtcaccattatgactattttatactggaggatctataaggaaactgaaaag cgtaccaaagagcttgctggcctgcaagcctctgggacagaggcagagacagaaaacttt gtccaccccacgggcagttctcgaagctgcagcagttacgaacttcaacagcaaagcatg aaacgctccaacaggaggaagtatggccgctgccacttctggttcacaaccaagagctgg aaacccagctccgagcagatggaccaagaccacagcagcagtgacagttggaacaacaat gatgctgctgcctccctggagaactccgcctcctccgacgaggaggacattggctccgag acgagagccatctactccatcgtgctcaagcttccgggtcacagcaccatcctcaactcc accaagttaccctcatcggacaacctgcaggtgcctgaggaggagctggggatggtggac ttggagaggaaagccgacaagctgcaggcccagaagagcgtggacgatggaggcagtttt ccaaaaagcttctccaagcttcccatccagctagagtcagccgtggacacagctaagact tctgacgtcaactcctcagtgggtaagagcacggccactctacctctgtccttcaaggaa gccactctggccaagaggtttgctctgaagaccagaagtcagatcactaagcggaaaagg atgtccctggtcaaggagaagaaagcggcccagaccctcagtgcgatcttgcttgccttc atcatcacttggaccccatacaacatcatggttctggtgaacaccttttgtgacagctgc atacccaaaaccttttggaatctgggctactggctgtgctacatcaacagcaccgtgaac cccgtgtgctatgctctgtgcaacaaaacattcagaaccactttcaagatgctgctgctg tgccagtgtgacaaaaaaaagaggcgcaagcagcagtaccagcagagacagtcggtcatt tttcacaagcgcgcacccgagcaggccttgtag

Homo sapiens (human): 1132 Help Entry 1132              CDS       T01001                                  Symbol CHRM4, HM4, M4R Name (RefSeq) cholinergic receptor muscarinic 4   KO K04132   muscarinic acetylcholine receptor M4 Organism hsa  Homo sapiens (human) Pathway hsa04080   Neuroactive ligand-receptor interaction hsa04725   Cholinergic synapse hsa04810   Regulation of actin cytoskeleton Drug target Acetylcholine (DG01133):  D00999<JP/US> Aclatonium (DG01291):  D01955 Aclidinium bromide:  D08837<JP/US> Anisotropine methylbromide:  D00232 Atropine (DG00052):  D00113<US> D02069<JP/US> Atropine oxide (DG01243):  D03011 D07477 Batefenterol (DG01627):  D10545 D10546 Benapryzine hydrochloride:  D03076 Benzatropine (DG00859):  D00778<US> D07511 Benzetimide (DG01301):  D03087 D07513 Benzilone:  D03088 Bethanechol (DG00991):  D01000<JP/US> Bevonium:  D01532 Biperiden (DG00852):  D00779 D02246<JP> D02247<JP> Blarcamesine (DG03048):  D11383 D11549 Bornaprine:  D07302 Butropium bromide:  D01491<JP> Butylscopolamine:  D01451<JP> Carbachol:  D00524<US> Carpronium (DG01289):  D01175<JP> D09752<JP> Chlorpromazine (DG00867):  D00270 D00789<JP/US> D03274 D04034<JP> D09819 Choline alfoscerate:  D07349 Cimetropium bromide:  D07099 Clidinium bromide:  D00716 Cyclopentolate (DG01141):  D01002<JP/US> D07759 Darotropium bromide:  D09402 Dexetimide (DG00856):  D03711 D07804 Diethazine (DG01921):  D02603 D07823 Difemerine:  D07079 Dihexyverine (DG00033):  D03824 D07821 Diphenidol (DG02880):  D01318<JP> D03858 D03859 Diphenylpiperidinomethyldioxolan iodide:  D01600 Diponium bromide:  D01463 Elantrine:  D03970 Elucaine:  D03979 Etomidoline:  D01359 Etybenzatropine:  D04087 Eucatropine hydrochloride:  D04116 Fenpiverinium:  D07070 Fentonium:  D07951 Flutropium bromide:  D02417 Glycopyrronium (DG02467):  D10939<JP/US> Heteronium bromide:  D04434 Homatropine (DG01142):  D01004 Homatropine methylbromide:  D02070 Hyoscyamine (DG00053):  D00147 D00719 D01648 D04479 Ipratropium bromide:  D02212<JP/US> Mazaticol (DG00857):  D03264<JP> D08157 Mebeverine (DG00030):  D04868 D08160 Mepenzolate (DG00040):  D00720<JP> Methacholine:  D04970<JP/US> Methantheline (DG00036):  D00721 Methscopolamine bromide:  D00715<US> Methylatropine (DG01242):  D01077 D03814 Methylbenactyzium bromide:  D01315 Methylscopolamine:  D01976<JP> Metixene (DG00853):  D01871 D08209 Metoquizine:  D05012 Milameline hydrochloride:  D05035 Otilonium bromide:  D07083 Oxapium iodide:  D01815 Oxitropium bromide:  D01946 Oxybutynin (DG00478):  D00465<US> D00722<JP/US> Parapenzolate bromide:  D05360 Pentapiperium methylsulfate:  D05418 Penthienate:  D07081 Phencarbamide:  D05452 Phenglutarimide:  D07301 Pipenzolate:  D07084 Piperidolate (DG00034):  D01165<JP> D08382 Pipethanate (DG01255):  D01521 D08384 Pipethanate ethobromide:  D01987 Pirenzepine (DG00026):  D01297 D05276<JP> D08389 Piroheptine (DG01272):  D01231<JP> D08395 Poldine:  D05535 Pridinol (DG00774):  D02064<JP> D08418 D08419 Prifinium bromide:  D01377 Procyclidine (DG00854):  D00782 D08425 Profenamine (DG00855):  D01118 D03276 D08426 Propantheline (DG00035):  D00481<JP/US> Propenzolate hydrochloride:  D05628 Propiverine (DG00479):  D01007<JP> D08441 Rapacuronium bromide:  D05703 Rocuronium bromide:  D00765<JP/US> Scopolamine (DG00065):  D00138<US> D02071<JP> Tazomeline citrate:  D06015 Tematropium methylsulfate:  D06061 Tiemonium (DG01254):  D08595 Tiemonium iodide:  D01201 Timepidium bromide (DG00041):  D02535<JP> Tofenacin hydrochloride:  D06175 Toquizine:  D06192 Triampyzine sulfate:  D06217 Trihexyphenidyl (DG00851):  D00787<JP/US> D08638 Tropatepine (DG00858):  D07303 D08653 Tropicamide:  D00397<JP/US> Umeclidinium (DG01253):  D10180 Umeclidinium bromide:  D10181<JP/US> Valethamate:  D01538 Xanomeline (DG01300):  D06330 D06331 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     1132 (CHRM4)  09140 Cellular Processes   09142 Cell motility    04810 Regulation of actin cytoskeleton     1132 (CHRM4)  09150 Organismal Systems   09156 Nervous system    04725 Cholinergic synapse     1132 (CHRM4)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     1132 (CHRM4) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Biogenic amine    Acetylcholine (muscarinic)     1132 (CHRM4) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7tm_4 Motif Other DBs NCBI-GeneID:  1132 NCBI-ProteinID:  NP_000732 OMIM:  118495 HGNC:  1953 Ensembl:  ENSG00000180720 Vega:  OTTHUMG00000154371 Pharos:  P08173(Tclin) UniProt:  P08173 Structure PDB LinkDB All DBs Position 11:complement(46383789..46391776) Genome browser AA seq 479 aa AA seqDB search MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGS ATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIV PATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV LVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR NT seq 1440 nt NT seq  +upstreamnt  +downstreamnt atggccaacttcacacctgtcaatggcagctcgggcaatcagtccgtgcgcctggtcacg tcatcatcccacaatcgctatgagacggtggaaatggtcttcattgccacagtgacaggc tccctgagcctggtgactgtcgtgggcaacatcctggtgatgctgtccatcaaggtcaac aggcagctgcagacagtcaacaactacttcctcttcagcctggcgtgtgctgatctcatc ataggcgccttctccatgaacctctacaccgtgtacatcatcaagggctactggcccctg ggcgccgtggtctgcgacctgtggctggccctggactacgtggtgagcaacgcctccgtc atgaaccttctcatcatcagctttgaccgctacttctgcgtcaccaagcctctcacctac cctgcccggcgcaccaccaagatggcaggcctcatgattgctgctgcctgggtactgtcc ttcgtgctctgggcgcctgccatcttgttctggcagtttgtggtgggtaagcggacggtg cccgacaaccagtgcttcatccagttcctgtccaacccagcagtgacctttggcacagcc attgctgccttctacctgcctgtggtcatcatgacggtgctgtacatccacatctccctg gccagtcgcagccgagtccacaagcaccggcccgagggcccgaaggagaagaaagccaag acgctggccttcctcaagagcccactaatgaagcagagcgtcaagaagcccccgcccggg gaggccgcccgggaggagctgcgcaatggcaagctggaggaggcccccccgccagcgctg ccaccgccaccgcgccccgtggctgataaggacacttccaatgagtccagctcaggcagt gccacccagaacaccaaggaacgcccagccacagagctgtccaccacagaggccaccacg cccgccatgcccgcccctcccctgcagccgcgggccctcaacccagcctccagatggtcc aagatccagattgtgacgaagcagacaggcaatgagtgtgtgacagccattgagattgtg cctgccacgccggctggcatgcgccctgcggccaacgtggcccgcaagttcgccagcatc gctcgcaaccaggtgcgcaagaagcggcagatggcggcccgggagcgcaaagtgacacga acgatctttgccattctgctagccttcatcctcacctggacgccctacaacgtcatggtc ctggtgaacaccttctgccagagctgcatccctgacacggtgtggtccattggctactgg ctctgctacgtcaacagcaccatcaaccctgcctgctatgctctgtgcaacgccaccttt aaaaagaccttccggcacctgctgctgtgccagtatcggaacatcggcactgccaggtag

Homo sapiens (human): 1133 Help Entry 1133              CDS       T01001                                  Symbol CHRM5, HM5 Name (RefSeq) cholinergic receptor muscarinic 5   KO K04133   muscarinic acetylcholine receptor M5 Organism hsa  Homo sapiens (human) Pathway hsa04020   Calcium signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04725   Cholinergic synapse hsa04810   Regulation of actin cytoskeleton hsa05010   Alzheimer disease hsa05022   Pathways of neurodegeneration - multiple diseases Network nt06410  Calcium signaling nt06460  Alzheimer disease   Element N01000   mAChR-Ca2+ -apoptotic pathway N01001   Mutation-caused aberrant Abeta to mAchR-Ca2+ -apoptotic pathway Drug target Acetylcholine (DG01133):  D00999<JP/US> Aclatonium (DG01291):  D01955 Aclidinium bromide:  D08837<JP/US> Anisotropine methylbromide:  D00232 Atropine (DG00052):  D00113<US> D02069<JP/US> Atropine oxide (DG01243):  D03011 D07477 Batefenterol (DG01627):  D10545 D10546 Benapryzine hydrochloride:  D03076 Benzatropine (DG00859):  D00778<US> D07511 Benzetimide (DG01301):  D03087 D07513 Benzilone:  D03088 Bethanechol (DG00991):  D01000<JP/US> Bevonium:  D01532 Biperiden (DG00852):  D00779 D02246<JP> D02247<JP> Blarcamesine (DG03048):  D11383 D11549 Bornaprine:  D07302 Butropium bromide:  D01491<JP> Butylscopolamine:  D01451<JP> Carbachol:  D00524<US> Carpronium (DG01289):  D01175<JP> D09752<JP> Chlorpromazine (DG00867):  D00270 D00789<JP/US> D03274 D04034<JP> D09819 Choline alfoscerate:  D07349 Cimetropium bromide:  D07099 Clidinium bromide:  D00716 Cyclopentolate (DG01141):  D01002<JP/US> D07759 Darotropium bromide:  D09402 Dexetimide (DG00856):  D03711 D07804 Diethazine (DG01921):  D02603 D07823 Difemerine:  D07079 Dihexyverine (DG00033):  D03824 D07821 Diphenidol (DG02880):  D01318<JP> D03858 D03859 Diphenylpiperidinomethyldioxolan iodide:  D01600 Diponium bromide:  D01463 Elantrine:  D03970 Elucaine:  D03979 Etomidoline:  D01359 Etybenzatropine:  D04087 Eucatropine hydrochloride:  D04116 Fenpiverinium:  D07070 Fentonium:  D07951 Flutropium bromide:  D02417 Glycopyrronium (DG02467):  D10939<JP/US> Heteronium bromide:  D04434 Homatropine (DG01142):  D01004 Homatropine methylbromide:  D02070 Hyoscyamine (DG00053):  D00147 D00719 D01648 D04479 Ipratropium bromide:  D02212<JP/US> Mazaticol (DG00857):  D03264<JP> D08157 Mebeverine (DG00030):  D04868 D08160 Mepenzolate (DG00040):  D00720<JP> Methacholine:  D04970<JP/US> Methantheline (DG00036):  D00721 Methscopolamine bromide:  D00715<US> Methylatropine (DG01242):  D01077 D03814 Methylbenactyzium bromide:  D01315 Methylscopolamine:  D01976<JP> Metixene (DG00853):  D01871 D08209 Metoquizine:  D05012 Milameline hydrochloride:  D05035 Otilonium bromide:  D07083 Oxapium iodide:  D01815 Oxitropium bromide:  D01946 Oxybutynin (DG00478):  D00465<US> D00722<JP/US> Parapenzolate bromide:  D05360 Pentapiperium methylsulfate:  D05418 Penthienate:  D07081 Phencarbamide:  D05452 Phenglutarimide:  D07301 Pipenzolate:  D07084 Piperidolate (DG00034):  D01165<JP> D08382 Pipethanate (DG01255):  D01521 D08384 Pipethanate ethobromide:  D01987 Pirenzepine (DG00026):  D01297 D05276<JP> D08389 Piroheptine (DG01272):  D01231<JP> D08395 Poldine:  D05535 Pridinol (DG00774):  D02064<JP> D08418 D08419 Prifinium bromide:  D01377 Procyclidine (DG00854):  D00782 D08425 Profenamine (DG00855):  D01118 D03276 D08426 Propantheline (DG00035):  D00481<JP/US> Propenzolate hydrochloride:  D05628 Propiverine (DG00479):  D01007<JP> D08441 Rapacuronium bromide:  D05703 Rocuronium bromide:  D00765<JP/US> Scopolamine (DG00065):  D00138<US> D02071<JP> Tazomeline citrate:  D06015 Tematropium methylsulfate:  D06061 Tiemonium (DG01254):  D08595 Tiemonium iodide:  D01201 Timepidium bromide (DG00041):  D02535<JP> Tofenacin hydrochloride:  D06175 Toquizine:  D06192 Triampyzine sulfate:  D06217 Trihexyphenidyl (DG00851):  D00787<JP/US> D08638 Tropatepine (DG00858):  D07303 D08653 Tropicamide:  D00397<JP/US> Umeclidinium (DG01253):  D10180 Umeclidinium bromide:  D10181<JP/US> Valethamate:  D01538 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04020 Calcium signaling pathway     1133 (CHRM5)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     1133 (CHRM5)  09140 Cellular Processes   09142 Cell motility    04810 Regulation of actin cytoskeleton     1133 (CHRM5)  09150 Organismal Systems   09156 Nervous system    04725 Cholinergic synapse     1133 (CHRM5)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     1133 (CHRM5)    05022 Pathways of neurodegeneration - multiple diseases     1133 (CHRM5)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     1133 (CHRM5) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Biogenic amine    Acetylcholine (muscarinic)     1133 (CHRM5) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7tm_4 7TM_GPCR_Srbc Motif Other DBs NCBI-GeneID:  1133 NCBI-ProteinID:  NP_001307846 OMIM:  118496 HGNC:  1954 Ensembl:  ENSG00000184984 Vega:  OTTHUMG00000129369 Pharos:  P08912(Tclin) UniProt:  P08912 A0A024R9I2 Structure PDB LinkDB All DBs Position 15:33968497..34067458 Genome browser AA seq 532 aa AA seqDB search MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQ LKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMN LLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPL DECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAE KRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQL TTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPN YLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNP NPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLG YWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP NT seq 1599 nt NT seq  +upstreamnt  +downstreamnt atggaaggggattcttaccacaatgcaaccaccgtcaatggcaccccagtaaatcaccag cctttggaacgccacaggttgtgggaagtcatcaccattgcagctgtgactgctgtggta agcctgatcaccattgtgggcaatgtcttggtcatgatctccttcaaagtcaacagccag ctcaagacagttaacaactattacctgctcagcttagcctgtgcagatctcatcattgga atcttctccatgaacctctacaccacctacatcctcatgggacgctgggctctcgggagt ctggcttgtgacctttggcttgcactggactacgtggccagcaacgcttctgtcatgaac cttctggtgatcagttttgaccgttacttttccatcacaagacccttgacatatcgggcc aagcgtactccgaaaagggctggcatcatgattggcttggcctggctgatctccttcatc ctctgggccccagcaatcctctgctggcagtacttggttgggaagcggacagttccactg gatgagtgccagatccagtttctctctgagcccaccatcacttttggcactgccattgct gccttctacatccctgtttctgtcatgaccatcctctactgtcgaatctaccgggaaaca gagaagcgaaccaaggacctggctgacctccagggttctgactctgtgaccaaagctgag aagagaaagccagctcatagggctctgttcagatcctgcttgcgctgtcctcgacccacc ctggcccagcgggaaaggaaccaggcctcctggtcatcctcccgcaggagcacctccacc actgggaagccatcccaagccactggcccaagcgccaattgggccaaagctgagcagctc accacctgtagcagctacccttcctcagaggatgaggacaagcccgccactgaccctgtc ctccaagtggtctacaagagtcagggtaaggaaagcccaggggaagaattcagtgctgaa gagactgaggaaacttttgtgaaagctgaaactgaaaaaagtgactatgacaccccaaac taccttctgtctccagcagctgctcatagacccaagagtcagaaatgtgtggcctataag ttccgattggtggtaaaagctgacgggaaccaggagaccaacaatggctgtcacaaggtg aaaatcatgccctgccccttcccagtggccaaggaaccttcaacgaaaggcctcaatccc aaccccagccatcaaatgaccaaacgaaagagagtggtcctagtcaaagagaggaaagca gcccagacactgagtgccattctcctggccttcatcatcacatggaccccgtataacatc atggtcctggtttctaccttctgtgacaagtgtgtcccagtcaccctgtggcacttgggc tattggttgtgctatgtcaatagcactgtcaaccccatctgctatgccctctgcaacaga accttcaggaagacctttaagatgctgcttctctgccgatggaaaaagaaaaaagtggaa gagaagttgtactggcaggggaacagcaagctaccctga

Homo sapiens (human): 623 Help Entry 623               CDS       T01001                                  Symbol BDKRB1, B1BKR, B1R, BKB1R, BKR1, BRADYB1 Name (RefSeq) bradykinin receptor B1   KO K03915   bradykinin receptor B1 Organism hsa  Homo sapiens (human) Pathway hsa04020   Calcium signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04610   Complement and coagulation cascades hsa04750   Inflammatory mediator regulation of TRP channels hsa04810   Regulation of actin cytoskeleton hsa05200   Pathways in cancer Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04020 Calcium signaling pathway     623 (BDKRB1)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     623 (BDKRB1)  09140 Cellular Processes   09142 Cell motility    04810 Regulation of actin cytoskeleton     623 (BDKRB1)  09150 Organismal Systems   09151 Immune system    04610 Complement and coagulation cascades     623 (BDKRB1)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     623 (BDKRB1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     623 (BDKRB1)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     623 (BDKRB1) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Peptide    Bradykinin     623 (BDKRB1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srw 7TM_GPCR_Srx Motif Other DBs NCBI-GeneID:  623 NCBI-ProteinID:  NP_000701 OMIM:  600337 HGNC:  1029 Ensembl:  ENSG00000100739 Vega:  OTTHUMG00000171412 Pharos:  P46663(Tchem) UniProt:  P46663 Structure PDB LinkDB All DBs Position 14:96256210..96264763 Genome browser AA seq 353 aa AA seqDB search MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLL VFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKAN LFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQA VPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRC GGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFF AFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN NT seq 1062 nt NT seq  +upstreamnt  +downstreamnt atggcatcatcctggccccctctagagctccaatcctccaaccagagccagctcttccct caaaatgctacggcctgtgacaatgctccagaagcctgggacctgctgcacagagtgctg ccaacatttatcatctccatctgtttcttcggcctcctagggaacctttttgtcctgttg gtcttcctcctgccccggcggcaactgaacgtggcagaaatctacctggccaacctggca gcctctgatctggtgtttgtcttgggcttgcccttctgggcagagaatatctggaaccag tttaactggcctttcggagccctcctctgccgtgtcatcaacggggtcatcaaggccaat ttgttcatcagcatcttcctggtggtggccatcagccaggaccgctaccgcgtgctggtg caccctatggccagccggaggcagcagcggcggaggcaggcccgggtcacctgcgtgctc atctgggttgtggggggcctcttgagcatccccacattcctgctgcgatccatccaagcc gtcccagatctgaacatcaccgcctgcatcctgctcctcccccatgaggcctggcacttt gcaaggattgtggagttaaatattctgggtttcctcctaccactggctgcgatcgtcttc ttcaactaccacatcctggcctccctgcgaacgcgggaggaggtcagcaggacaaggtgc gggggccgcaaggatagcaagaccacagcgctgatcctcacgctcgtggttgccttcctg gtctgctgggccccttaccacttctttgccttcctggaattcttattccaggtgcaagca gtccgaggctgcttttgggaggacttcattgacctgggcctgcaattggccaacttcttt gccttcactaacagctccctgaatccagtaatttatgtctttgtgggccggctcttcagg accaaggtctgggaactttataaacaatgcacccctaaaagtcttgctccaatatcttca tcccataggaaagaaatcttccaacttttctggcggaattaa

Homo sapiens (human): 624 Help Entry 624               CDS       T01001                                  Symbol BDKRB2, B2R, BK-2, BK2, BKR2, BRB2 Name (RefSeq) bradykinin receptor B2   KO K03916   bradykinin receptor B2 Organism hsa  Homo sapiens (human) Pathway hsa04020   Calcium signaling pathway hsa04022   cGMP-PKG signaling pathway hsa04071   Sphingolipid signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04610   Complement and coagulation cascades hsa04750   Inflammatory mediator regulation of TRP channels hsa04810   Regulation of actin cytoskeleton hsa04961   Endocrine and other factor-regulated calcium reabsorption hsa05142   Chagas disease hsa05200   Pathways in cancer Drug target Deltibant:  D03677 Icatibant:  D04492<JP/US> Labradimil:  D08937 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04020 Calcium signaling pathway     624 (BDKRB2)    04071 Sphingolipid signaling pathway     624 (BDKRB2)    04022 cGMP-PKG signaling pathway     624 (BDKRB2)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     624 (BDKRB2)  09140 Cellular Processes   09142 Cell motility    04810 Regulation of actin cytoskeleton     624 (BDKRB2)  09150 Organismal Systems   09151 Immune system    04610 Complement and coagulation cascades     624 (BDKRB2)   09155 Excretory system    04961 Endocrine and other factor-regulated calcium reabsorption     624 (BDKRB2)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     624 (BDKRB2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     624 (BDKRB2)   09174 Infectious disease: parasitic    05142 Chagas disease     624 (BDKRB2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     624 (BDKRB2) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Peptide    Bradykinin     624 (BDKRB2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  7tm_1 Motif Other DBs NCBI-GeneID:  624 NCBI-ProteinID:  NP_000614 OMIM:  113503 HGNC:  1030 Ensembl:  ENSG00000168398 Vega:  OTTHUMG00000171408 Pharos:  P30411(Tclin) UniProt:  P30411 Structure PDB LinkDB All DBs Position 14:96204839..96244164 Genome browser AA seq 391 aa AA seqDB search MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQ PPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNN FDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLV IWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVI TFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGI LSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEP IQMENSMGTLRTSISVERQIHKLQDWAGSRQ NT seq 1176 nt NT seq  +upstreamnt  +downstreamnt atgttctctccctggaagatatcaatgtttctgtctgttcgtgaggactccgtgcccacc acggcctctttcagcgccgacatgctcaatgtcaccttgcaagggcccactcttaacggg acctttgcccagagcaaatgcccccaagtggagtggctgggctggctcaacaccatccag ccccccttcctctgggtgctgttcgtgctggccaccctagagaacatctttgtcctcagc gtcttctgcctgcacaagagcagctgcacggtggcagagatctacctggggaacctggcc gcagcagacctgatcctggcctgcgggctgcccttctgggccatcaccatctccaacaac ttcgactggctctttggggagacgctctgccgcgtggtgaatgccattatctccatgaac ctgtacagcagcatctgtttcctgatgctggtgagcatcgaccgctacctggccctggtg aaaaccatgtccatgggccggatgcgcggcgtgcgctgggccaagctctacagcttggtg atctgggggtgtacgctgctcctgagctcacccatgctggtgttccggaccatgaaggag tacagcgatgagggccacaacgtcaccgcttgtgtcatcagctacccatccctcatctgg gaagtgttcaccaacatgctcctgaatgtcgtgggcttcctgctgcccctgagtgtcatc accttctgcacgatgcagatcatgcaggtgctgcggaacaacgagatgcagaagttcaag gagatccagacagagaggagggccacggtgctagtcctggttgtgctgctgctattcatc atctgctggctgcccttccagatcagcaccttcctggatacgctgcatcgcctcggcatc ctctccagctgccaggacgagcgcatcatcgatgtaatcacacagatcgcctccttcatg gcctacagcaacagctgcctcaacccactggtgtacgtgatcgtgggcaagcgcttccga aagaagtcttgggaggtgtaccagggagtgtgccagaaagggggctgcaggtcagaaccc attcagatggagaactccatgggcacactgcggacctccatctccgtggaacgccagatt cacaaactgcaggactgggcagggagcagacagtga

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